Atp2a3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Atp2a3	0.16	0.08	0.0e+00	0.18	0.2	0.2	0.2	1.7e-16	2.7e-18	1.2e-18	1.3e-18
2	Adipose	mRNA stability	Atp2a3	0.06	0.04	4.3e-06	0.02	0.03	0.03	0.03	1.1e-03	2.4e-04	4.9e-04	5.8e-04
3	BLA	gene expression	Atp2a3	0.13	0.09	1.0e-04	0.09	0.07	0.06	0.06	2.4e-05	1.1e-04	5.2e-04	2.2e-04
4	Adipose	gene expression	Atp2a3	0.17	0.1	5.8e-08	0.04	0.06	0.05	0.06	4.9e-05	1.6e-07	3.0e-06	1.5e-07
5	PL	gene expression	Atp2a3	0.05	0.03	7.6e-04	0.01	0.02	0.01	0.02	4.7e-02	9.8e-04	2.4e-02	2.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.7	1.2	2.9	-0.4	-0.1	-0.8	-1.7	1.5
Area under the delay curve	0.1	0.1	0.2	0.5	0.3	-0.1	0.3	-0.3
BMI with tail	0.2	0.5	0.9	0.7	0.7	-0.9	-0.1	0.9
BMI without tail	0.4	0.9	1.7	0.7	0.8	-1.2	-0.6	1.3
Body weight	0.8	3.5	7.6	-0.0	0.3	-1.6	-2.7	2.8
Weight adjusted by age	2.5	2.8	4.2	1.9	1.9	-2.0	1.0	1.2
Bone surface	0.7	1.2	2.1	0.7	1.0	-1.5	-0.6	1.5
Bone volume	1.0	1.7	3.0	1.1	1.3	-1.7	-0.5	1.6
Breakpoint value in progressive ratio session	0.7	0.8	1.7	0.4	0.4	-1.3	-0.3	1.3
Number of licking bursts	0.2	0.2	0.4	-0.4	-0.5	0.6	0.1	-0.5
Context. condit. distance diff. score	0.9	1.1	2.0	0.7	0.9	-1.4	-0.7	1.4
Locomotion velocity, session 1	2.4	2.6	5.1	1.0	1.0	-1.8	-1.5	2.3
Locomotion distance, session 1	0.9	1.2	1.8	1.3	1.2	-1.3	0.1	1.0
Locomotion velocity, session 2	0.5	0.5	1.2	-0.9	-0.8	0.3	-1.1	0.4
Locomotion distance, session 2	0.3	0.4	0.9	0.2	0.2	-0.6	-0.9	0.9
Locomotion velocity, session 3	1.8	2.1	3.4	-1.5	-1.5	1.8	0.3	-1.6
Locomotion distance, session 3	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.2	-0.3
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	-0.3	-0.2	0.2	-0.5	0.1
Stereotopy head waving duration, day 3	0.6	0.7	2.1	0.5	0.6	0.1	1.5	-0.9
Locomotion velocity, session 7	0.0	0.0	0.1	0.2	0.2	-0.2	0.2	0.0
Locomotion distance, session 7	0.0	0.0	0.1	-0.3	-0.2	0.1	-0.2	0.1
Stereotopy head waving bouts, day 7	0.7	0.8	1.3	0.7	1.0	-1.1	-0.3	1.1
Stereotopy head waving duration, day 7	0.9	1.1	1.8	0.8	1.1	-1.3	-0.5	1.3
Locomotion velocity, session 8	0.8	1.0	1.6	1.0	1.1	-1.3	-0.1	1.0
Locomotion distance, session 8	1.5	2.2	4.4	0.6	0.9	-1.8	-1.4	2.1
Degree of sensitization distance	0.6	0.6	0.9	0.9	0.8	-1.0	-0.0	0.8
Degree of sensitization stereotypy	1.1	1.2	2.5	0.4	0.7	-1.2	-1.0	1.6
Conditioned locomotion	0.7	0.8	1.6	-0.5	-0.7	1.1	0.7	-1.3
Cocaine response after cond. corrected	0.6	0.7	1.2	-1.0	-0.9	0.5	-1.1	0.2
Cocaine response after cond. not corrected	0.4	0.4	1.0	-0.7	-0.6	0.1	-1.0	0.5
Cocaine response before conditioning	0.6	0.7	1.1	0.9	1.0	-1.0	0.1	0.8
Saline control response	0.5	0.6	0.9	1.0	0.8	-1.0	0.0	0.7
Bone: connectivity density	0.9	1.4	3.1	0.1	0.4	-1.2	-1.5	1.8
Bone: cortical apparent density	0.9	1.2	1.8	-1.0	-1.1	1.3	0.5	-1.3
Bone: cortical area	0.2	0.4	0.9	0.1	0.1	0.4	1.0	-0.9
Bone: cortical porosity	1.8	2.0	3.3	-1.8	-1.6	1.1	-1.7	0.0
Bone: cortical porosity	1.7	1.8	3.0	-1.7	-1.6	1.2	-1.4	-0.2
Bone: cortical thickness	1.8	3.0	4.8	-1.8	-1.9	2.2	0.3	-1.8
Bone: cortical thickness	3.4	4.0	6.5	-2.6	-2.5	2.1	-1.2	-1.0
Bone: cortical tissue density	0.7	1.0	1.4	-0.9	-1.0	1.2	0.4	-1.2
Condit. Reinf. active minus inactive responses	0.8	0.9	1.5	-1.1	-1.2	0.9	-1.2	-0.1
Condit. Reinf. active-inactive response ratio	0.5	0.6	0.9	-0.8	-0.9	0.7	-0.8	-0.1
Condit. Reinf. active responses	0.6	0.7	1.2	-0.9	-1.0	0.7	-1.1	0.1
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.1	-0.2	0.2	-0.0	-0.1
Incentive salience index mean	1.2	1.4	2.7	-1.3	-1.4	0.9	-1.6	0.2
Condit. Reinf. lever presses	1.8	2.4	6.0	-1.5	-1.6	0.7	-2.4	0.8
Condit. Reinf. active minus inactive responses	0.6	0.7	1.2	-1.0	-1.1	0.7	-0.9	0.0
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.3	-1.1	-1.2	0.9	-0.7	-0.3
Condit. Reinf. active responses	0.2	0.3	0.5	-0.6	-0.7	0.4	-0.6	0.1
Condit. Reinf. inactive responses	0.1	0.2	0.3	0.5	0.4	-0.3	0.5	-0.1
Condit. Reinf. lever presses	0.4	0.5	1.1	-0.1	-0.4	0.8	0.9	-1.1
Condit. Reinf. lever reinforcers received	0.1	0.2	0.4	-0.5	-0.6	0.4	-0.4	-0.1
Conditioned reinforcement - actives	0.9	0.9	1.3	1.1	0.9	-1.1	1.1	0.5
Conditioned reinforcement - inactives	1.6	1.8	2.6	1.6	1.5	-1.5	1.0	0.8
Conditioned locomotion	0.5	0.6	1.0	1.0	0.9	-0.5	0.9	-0.2
Patch foraging indifference point 0 sec	1.2	2.0	3.4	-1.8	-1.8	1.3	-1.3	-0.4
Patch foraging indifference point AUC	2.2	2.5	4.2	1.9	1.8	-1.3	2.1	-0.3
Delay disc. indifference point, 0s delay	1.8	2.0	3.2	1.7	1.8	-1.6	0.2	1.0
Delay disc. indifference point, 16s delay	0.7	0.8	1.5	1.1	0.9	-0.6	1.2	-0.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.2	-0.2	0.4	-0.4	-0.4
Delay disc. indifference point, 24s delay	0.5	0.5	0.8	-0.7	-0.9	0.8	-0.1	-0.7
Delay disc. indifference point, 4s delay	0.4	0.5	0.8	0.9	0.9	-0.7	0.1	0.4
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.3	0.1	-0.1	-0.1	-0.0
Indifference point function ln k	5.6	7.8	12.4	-3.5	-3.5	2.8	-2.4	-0.8
Indifference point function log k	5.6	7.8	12.4	-3.5	-3.5	2.8	-2.4	-0.8
Patch foraging total patch changes 0 sec	0.8	1.3	2.2	-1.5	-1.4	1.0	-1.1	-0.3
Patch foraging total patch changes 12 sec	1.0	1.3	2.0	1.4	1.4	-1.3	0.8	0.5
Patch foraging total patch changes 18 sec	0.5	0.7	1.0	1.0	1.0	-1.0	0.5	0.4
Patch foraging total patch changes 24 sec	0.6	0.7	1.1	1.0	0.9	-0.7	1.1	-0.2
Patch foraging total patch changes 6 sec	1.2	1.8	2.8	1.6	1.7	-1.2	1.4	0.1
Patch foraging time to switch 0 sec	1.1	1.7	2.6	1.4	1.6	-1.5	0.1	1.2
Patch foraging water rate 0 sec	0.7	1.1	1.8	-1.1	-1.1	1.3	0.2	-1.2
Patch foraging water rate 12 sec	0.2	0.3	0.5	0.2	0.3	-0.6	-0.5	0.7
Patch foraging water rate 18 sec	0.6	0.8	2.2	-0.8	-0.9	0.3	-1.5	0.6
Patch foraging water rate 24 sec	0.0	0.0	0.0	0.1	0.0	0.1	0.2	-0.2
Patch foraging water rate 6 sec	0.3	0.5	0.7	-0.6	-0.7	0.9	0.2	-0.8
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.1	-0.6	-0.5	1.0	-0.2	-0.8
Distance traveled before self-admin	0.5	0.5	0.9	0.8	0.8	-0.3	0.9	-0.4
Distance traveled after self-admin	5.3	5.9	9.9	3.1	3.2	-2.6	0.8	1.5
Extensor digitorum longus weight	3.0	11.8	16.8	4.1	4.1	-4.1	0.6	2.9
Bone: elastic displacement	0.3	0.4	0.9	-0.2	-0.2	0.5	0.9	-0.9
Bone: elastic work	1.0	1.3	2.3	-1.0	-1.0	1.3	0.7	-1.5
Bone: endosteal estimation	2.6	5.6	9.2	3.0	3.0	-2.4	1.8	0.9
Bone: endosteal perimeter	2.8	5.8	9.9	3.1	3.1	-2.5	1.6	1.1
Epididymis fat weight	3.3	7.7	12.0	2.7	2.8	-3.5	-0.9	3.3
Delta time in closed arm before/after self-admin	1.1	1.1	2.1	1.4	1.4	-0.9	0.6	0.4
Delta time in open arm before/after self-admin	0.6	0.6	0.9	0.8	0.8	-1.0	0.2	0.8
Diff in mean of infusions in LGA sessions	0.3	0.3	0.6	-0.8	-0.7	-0.0	-0.5	0.7
Delay discount exponential model param	0.0	0.0	0.1	-0.2	-0.0	-0.1	-0.0	0.3
Extinction: sum of active levers before priming	1.1	1.1	2.6	0.6	0.7	-1.3	-0.6	1.6
Active lever presses in extinction session 6	1.3	1.3	2.4	1.1	1.1	-1.5	0.1	1.3
Bone: final force	0.5	0.8	1.2	1.0	1.1	-1.1	0.2	0.6
Bone: final moment	0.5	0.8	1.3	1.1	1.2	-1.0	0.5	0.5
Food consumed during 24 hour testing period	0.6	0.7	1.1	-1.1	-1.0	0.7	-1.0	0.0
Glucose	1.2	1.9	4.7	0.5	0.2	0.9	2.2	-1.9
Heart weight	1.0	1.4	2.2	1.2	1.3	-1.5	-0.2	1.2
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.3	-0.1	-0.0	-0.0	0.2
Intermittent access intake day 1-15 change	1.8	1.8	4.5	1.5	1.2	-0.3	2.1	-0.8
Intermittent access intake escalation	1.8	1.7	4.1	1.4	1.2	-0.1	2.0	-1.1
Intermittent access intake escalation 2	1.3	1.3	2.8	0.7	0.4	0.6	1.7	-1.6
Intermitt. access day 1 inactive lever presses	0.6	0.7	1.3	-0.2	-0.2	0.8	1.1	-1.1
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.4	-0.6	-0.5	0.6	-0.5	-0.1
Intermitt. access escalation Index	1.6	1.5	3.1	-0.1	0.2	-1.1	-1.7	1.7
Intermittent access day 1 total infusions	2.0	2.3	3.9	1.8	1.6	-2.0	0.7	1.1
Intermittent access day 15 total infusions	4.9	5.5	9.2	3.0	2.8	-2.2	2.4	0.4
Intermittent access terminal intake (last 3 days)	4.1	4.4	7.6	2.8	2.5	-2.3	1.4	1.1
Intermittent access total infusions	2.5	2.8	4.6	2.1	1.9	-1.8	1.5	0.6
Intermittent access day 1 locomotion	1.2	1.3	2.2	1.3	1.5	-1.2	0.4	0.8
Intermittent access day 15 total locomotion	1.4	1.5	2.9	1.7	1.6	-0.7	1.3	-0.1
Intermittent access total locomotion	0.4	0.5	0.9	0.9	1.0	-0.6	0.5	0.3
Intermittent access standard deviation	4.8	5.1	10.3	2.7	2.4	-1.2	3.2	-0.8
Left kidney weight	0.2	0.4	0.7	0.8	0.8	-0.7	0.7	-0.0
Right kidney weight	0.1	0.2	0.3	0.5	0.6	-0.6	0.5	-0.0
Cocaine induced anxiety	2.4	2.7	4.2	-1.9	-1.9	2.0	0.2	-1.6
Post-drug Anxiety	0.7	0.8	1.3	-1.1	-1.1	1.0	-0.2	-0.6
Baseline Anxiety	1.2	1.3	2.1	1.5	1.3	-1.4	0.2	0.9
Tail length	1.7	5.2	11.4	0.4	0.7	-2.0	-3.1	3.4
Length with tail	1.0	3.6	9.3	-0.3	-0.0	-1.3	-3.0	2.7
Length without tail	0.7	1.5	3.2	-0.0	0.2	-1.0	-1.8	1.8
Times rat made contact with spout	1.0	1.2	1.9	-1.4	-1.3	1.2	-0.8	-0.5
Lifetime Intake	3.6	4.1	6.8	2.6	2.3	-2.2	1.7	0.8
Liver weight, left	0.4	0.7	2.2	-0.6	-0.4	-0.2	-1.5	1.0
Liver weight, right	0.8	1.3	2.7	0.6	0.8	-1.3	-1.1	1.6
Locomotor activity	0.5	0.8	1.2	1.1	1.0	-1.1	0.1	0.8
Locomotor testing distance	2.4	4.0	6.6	2.6	2.5	-2.2	1.1	1.2
Locomotor testing rearing	3.5	5.4	9.4	3.1	2.9	-2.4	1.7	0.9
Locomotion in novel chamber	1.8	2.2	6.5	1.1	0.9	0.2	2.5	-1.6
Locomotion in novel chamber post-restriction	0.3	0.3	0.6	-0.6	-0.6	0.8	0.1	-0.6
Fecal boli incidents, locomotor time 1	0.4	0.4	0.9	-0.9	-0.8	0.8	-0.2	-0.3
Change in fecal boli incidents, locomotor task	0.5	0.4	0.7	-0.9	-0.9	0.7	-0.2	-0.5
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	-0.9	-0.8	0.5	-0.5	-0.2
Bouts of movement, locomotor time 1	0.7	0.8	1.7	-1.3	-1.2	0.8	-0.3	-0.3
Total resting periods, locomotor time 1	1.7	1.9	3.5	-1.9	-1.8	1.4	-0.4	-0.7
Rest time, locomotor task time 1	0.5	0.6	0.8	-0.9	-0.8	0.8	0.1	-0.9
Distance moved, locomotor task time 1	1.2	1.3	2.3	1.5	1.3	-1.3	0.8	0.7
Vertical activity count, locomotor time 1	1.0	1.0	1.5	1.2	1.1	-1.2	0.1	0.9
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.0	-1.0	-1.0	0.8	-0.4	-0.5
Bouts of movement, locomotor time 2	1.1	1.2	2.1	-1.4	-1.4	1.2	-0.2	-0.7
Total resting periods, locomotor time 2	0.7	0.8	1.5	-1.2	-1.2	0.9	-0.3	-0.4
Rest time, locomotor task time 2	1.0	1.2	1.8	-1.3	-1.2	1.3	-0.0	-0.9
Distance moved, locomotor task time 2	2.4	2.8	5.4	2.3	1.9	-1.7	1.3	0.5
Vertical activity count, locomotor time 2	0.9	1.0	1.8	1.3	1.1	-1.2	-0.1	0.6
Light reinforcement 1	1.3	2.4	3.8	1.9	1.8	-1.8	1.0	0.8
Light reinforcement 2	0.2	0.2	0.5	0.5	0.5	-0.4	0.7	-0.2
Bone: marrow area	2.5	5.5	9.0	3.0	3.0	-2.4	1.8	0.9
Bone: maximum diameter	0.7	1.4	2.2	1.5	1.4	-0.8	1.4	-0.2
Bone: maximum force	0.5	0.9	1.4	1.2	1.2	-1.1	0.5	0.5
Bone: maximum moment	0.6	1.1	1.8	1.3	1.3	-1.1	0.8	0.4
Mean time between licks in bursts	1.3	1.8	2.9	1.1	1.3	-1.7	-0.7	1.7
Mean num. licks in bursts	0.1	0.1	0.3	-0.4	-0.3	0.0	-0.5	0.3
Cd content in liver	1.0	1.1	1.8	1.1	1.2	-1.3	-0.0	1.0
Co content in liver	0.1	0.2	0.3	0.3	0.5	-0.6	-0.1	0.4
Cu content in liver	2.4	2.9	4.5	-2.1	-2.1	1.9	-1.2	-0.9
Fe content in liver	0.4	0.5	1.5	-0.5	-0.3	-0.2	-1.2	0.8
K content in liver	0.5	0.5	1.4	-0.3	-0.2	-0.3	-1.2	0.9
Mg content in liver	0.0	0.0	0.1	0.1	0.1	0.0	0.2	-0.1
Mn content in liver	1.2	1.4	2.2	-1.4	-1.5	1.1	-1.2	-0.3
Na content in liver	0.2	0.2	0.4	0.5	0.3	0.0	0.7	-0.4
Rb content in liver	0.7	0.9	1.5	1.2	1.2	-1.0	0.5	0.6
Se content in liver	0.8	1.0	1.6	-0.9	-1.1	1.3	0.1	-1.0
Sr content in liver	1.4	1.3	1.9	1.3	1.3	-1.4	0.1	1.0
Zn content in liver	0.2	0.2	0.4	-0.6	-0.4	0.6	0.2	-0.5
Bone: minimum diameter	1.7	3.1	5.1	2.3	2.2	-1.9	1.0	0.9
Time in familiar zone, hab. session 1	0.3	0.2	0.8	0.4	0.3	-0.1	0.9	-0.4
Time in novel zone, hab. session 1	0.4	0.4	0.9	-0.7	-0.6	0.4	-0.9	0.2
Total zone transitions, hab. session 1	4.4	6.2	10.5	3.2	3.0	-2.7	1.5	1.3
Total locomotion distance, hab. session 1	0.3	0.4	0.7	0.8	0.7	-0.8	0.2	0.5
Locomotion velocity, hab. session 1	0.4	0.6	1.0	1.0	0.9	-0.9	0.4	0.4
Time in familiar zone, hab. session 2	0.2	0.2	0.4	-0.6	-0.5	0.2	-0.6	0.2
Time in novel zone, hab. session 2	0.3	0.3	0.7	-0.3	-0.4	0.7	0.4	-0.8
Total zone transitions, hab. session 2	2.3	2.9	4.7	1.9	2.0	-2.2	0.3	1.5
Total locomotion distance, hab. session 2	0.4	0.6	1.0	0.8	0.8	-1.0	0.1	0.7
Locomotion velocity, hab. session 2	0.5	0.6	1.1	0.9	0.9	-1.0	0.3	0.6
Novel to familiar place preference ratio	0.1	0.1	0.4	0.2	0.2	0.0	0.6	-0.4
Novelty place preference	0.0	0.0	0.0	-0.1	-0.0	0.1	0.2	-0.2
Time in novel zone, NPP test	0.0	0.0	0.0	-0.2	-0.1	0.0	-0.1	-0.0
Total zone transitions, NPP test	2.7	3.9	5.8	2.4	2.4	-2.4	0.8	1.4
Total locomotion distance, NPP test	0.3	0.4	0.9	0.8	0.8	-0.5	0.9	-0.2
Locomotion velocity, NPP test	0.4	0.6	1.7	0.6	0.6	-0.1	1.3	-0.6
Intraocular pressure	2.0	2.7	4.6	2.1	1.8	-1.1	2.1	-0.5
Delta distance traveled before/after self-admin	3.1	3.3	4.7	1.9	2.0	-2.2	-0.5	2.0
Delta ambulatory time before/after self-admin	1.8	2.0	2.6	1.5	1.5	-1.6	-0.6	1.6
Parametrial fat weight	9.8	19.0	30.3	4.1	4.2	-5.5	-1.7	5.3
Pavlov. Cond. lever latency	1.7	2.1	3.5	1.8	1.9	-1.5	1.3	0.4
Pavlov. Cond. magazine entry latency	2.7	3.5	5.6	-2.3	-2.4	1.6	-2.0	-0.2
Pavlov. Cond. change in total contacts	1.6	1.7	2.6	-1.4	-1.6	1.6	-0.4	-1.1
Pavlov. Cond. index score	1.9	2.4	3.7	-1.9	-1.9	1.2	-1.8	0.0
Pavlov. Cond. latency score	2.2	2.8	4.3	-2.0	-2.0	1.2	-2.1	0.2
Pavlov. Cond. lever contacts	1.3	1.5	2.4	-1.5	-1.5	1.1	-1.3	-0.1
Pavlov. Cond. magazine entry number	1.3	1.6	2.7	1.5	1.7	-1.2	1.1	0.4
Pavlov. Cond. intertrial magazine entries	2.4	2.9	4.9	2.2	2.2	-1.7	1.3	0.7
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.2	3.4	-1.8	-1.8	1.2	-1.6	-0.1
Pavlov. Cond. response bias	1.6	1.9	3.2	-1.7	-1.8	1.3	-1.4	-0.2
Pavlov. Cond. lever latency	1.5	2.0	3.6	1.1	1.3	-1.7	-1.0	1.9
Pavlov. Cond. magazine entry latency	0.9	1.1	1.6	-1.2	-1.2	1.3	0.0	-1.0
Pavlov. Cond. change in total contacts	0.6	0.9	1.3	-0.9	-1.0	1.1	0.3	-1.1
Pavlov. Cond. index score	1.1	1.5	3.0	-0.6	-0.8	1.3	1.3	-1.7
Pavlov. Cond. latency score	1.4	1.8	3.7	-0.6	-0.8	1.4	1.5	-1.9
Pavlov. Cond. lever contacts	0.5	0.7	1.5	-0.4	-0.7	0.9	0.8	-1.2
Pavlov. Cond. magazine entry number	0.7	0.8	1.3	0.8	0.9	-1.1	-0.6	1.2
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.4	1.0	1.0	-1.2	-0.3	1.2
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	3.0	-0.7	-0.9	1.3	1.2	-1.7
Pavlov. Cond. response bias	0.8	1.0	1.8	-0.8	-1.0	1.2	0.7	-1.3
Time in closed arm before self-admin	1.5	1.7	4.2	-1.5	-1.1	0.4	-2.0	0.9
Time in closed arm after self-admin	0.2	0.3	0.8	-0.5	-0.2	0.4	-0.9	0.2
Time in open arm before self-admin	0.9	1.0	2.6	-0.0	-0.3	1.0	1.1	-1.6
Time in open arm after self-admin	1.4	1.5	3.9	1.4	1.0	-0.5	2.0	-0.8
Bone: periosteal estimation	1.2	2.5	4.1	2.0	2.0	-1.4	1.5	0.3
Bone: periosteal perimeter	0.8	1.4	2.5	1.6	1.5	-1.0	1.1	0.2
Bone: post-yield work	0.5	0.6	1.4	0.4	0.5	-0.9	-0.9	1.2
Progressive ratio test 1 active lever presses	1.3	1.3	2.1	1.3	1.2	-1.5	0.4	1.1
Progressive ratio test 1 breakpoint	1.8	1.9	3.3	1.4	1.3	-1.8	0.2	1.6
Progressive ratio test 1 inactive lever presses	1.0	1.1	1.8	1.3	1.2	-1.1	0.9	0.3
Progressive ratio test 2 active lever presses	0.9	0.9	1.4	1.2	0.9	-1.2	0.8	0.6
Progressive ratio test 2 breakpoint	0.4	0.5	0.7	0.8	0.6	-0.8	0.8	0.4
Progressive ratio test 2 inactive lever presses	1.7	2.0	3.2	1.8	1.7	-1.5	1.1	0.7
Incentive Sensitization - Responses	0.1	0.1	0.2	0.1	0.1	-0.5	0.3	0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.2	0.1	-0.4	0.3	0.2
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.8	-0.5	-0.3	-0.6	-1.1	1.3
Progressive ratio	0.7	0.8	1.8	1.3	1.2	-0.7	0.5	0.3
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.1	-0.1	0.3	-0.5	-0.3
Seeking ratio, punishment vs. effort	1.2	1.4	2.5	-1.6	-1.4	1.1	-1.1	-0.5
Retroperitoneal fat weight	0.2	0.7	1.2	1.1	0.9	-0.5	1.1	-0.1
Reaction time number correct	0.1	0.2	0.4	-0.6	-0.3	0.1	-0.7	0.4
Reaction time mean minus median	0.5	0.6	1.2	-0.5	-0.5	0.9	0.7	-1.1
Reaction time mean minus median AUC	0.1	0.1	0.3	-0.0	-0.1	0.4	0.5	-0.5
Reaction time num false alarms	0.9	1.2	1.8	-1.0	-1.1	1.3	0.4	-1.3
Reaction time num false alarms AUC	0.8	1.0	1.7	-0.9	-1.0	1.2	0.6	-1.3
Reaction time trials correct on left	0.1	0.2	0.4	-0.6	-0.3	0.1	-0.7	0.4
Reaction time trials on left	0.1	0.2	0.4	-0.5	-0.3	0.1	-0.6	0.3
Reaction time mean	0.2	0.2	0.4	-0.3	-0.3	0.6	0.4	-0.6
Reaction time mean AUC	0.4	0.6	1.1	-0.4	-0.5	0.9	0.7	-1.0
Median of all reaction times	0.1	0.1	0.2	-0.0	-0.1	0.3	0.4	-0.4
Reaction time omissions	0.4	0.5	0.9	1.0	0.9	-0.8	0.6	0.2
Reaction time false alarm rate	0.5	0.7	1.4	-0.5	-0.7	0.9	0.7	-1.2
Reaction time premature initiation rate	1.9	2.6	4.1	-2.0	-1.9	1.6	-1.6	-0.2
Reaction time premature initiations	1.9	2.6	4.4	-2.1	-1.8	1.4	-1.8	0.0
Std. dev. reaction times	0.9	1.3	2.0	-1.0	-1.1	1.4	0.6	-1.4
Reaction time trials completed	0.1	0.2	0.4	-0.5	-0.3	0.1	-0.6	0.3
Reaction time trials AUC	0.1	0.2	0.4	-0.6	-0.3	0.2	-0.6	0.3
Run reversals in cocaine runway, females	0.2	0.2	0.3	-0.2	-0.3	0.5	0.3	-0.5
Run reversals in cocaine runway, males	1.7	1.7	2.9	1.5	1.6	-0.9	1.7	-0.2
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.0	-0.1	0.0	-0.5	0.1
Latency to leave start box in cocaine runway, F	0.4	0.4	1.5	-0.0	-0.1	-0.1	-1.2	0.7
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	0.5	0.5	-0.6	0.1	0.2
Std. dev. time between licks in bursts	0.4	0.4	0.8	0.5	0.6	-0.9	-0.3	0.8
Total sessions with >9 infusions	2.4	2.7	4.4	2.1	1.9	-1.9	0.8	1.1
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.0	0.2	-0.2	0.2	0.3
Short access day 10 total inactive lever presses	0.4	0.4	1.0	-1.0	-0.7	0.6	-0.5	-0.1
Short access day 1 total infusions	3.5	3.8	5.7	2.4	2.3	-1.6	2.3	0.1
Short access day 10 total infusions	1.9	2.1	3.2	1.8	1.5	-1.6	1.5	0.5
Short access total infusions	4.1	4.6	7.8	2.8	2.5	-2.1	2.0	0.6
Short access day 1 locomotion	1.4	1.5	3.3	1.4	1.3	-0.6	1.8	-0.3
Short access day 10 total locomotion	0.3	0.3	0.6	0.6	0.7	-0.3	0.8	-0.1
Short access total locomotion	0.5	0.5	1.0	0.8	0.9	-0.4	1.0	-0.1
One hour access (0.3 mA shock)	1.9	2.2	3.5	1.9	1.5	-1.6	1.6	0.5
Compulsive drug intake	1.5	1.5	2.7	-1.6	-1.5	0.9	-1.4	0.1
One hour access (shock baseline)	2.7	3.1	5.0	2.2	2.0	-1.8	1.7	0.5
Social response proportion	2.9	3.1	8.9	-1.5	-1.5	0.3	-3.0	1.4
Social responses	1.8	2.3	4.3	1.1	1.1	-1.9	-1.2	2.1
Social time	1.1	1.4	3.0	0.6	0.7	-1.2	-1.3	1.7
Soleus weight	2.3	6.8	13.9	1.4	1.6	-2.9	-2.6	3.7
Bone: stiffness	1.7	2.8	4.7	1.3	1.4	-2.0	-1.1	2.2
Tibialis anterior weight	3.0	10.2	15.5	3.3	3.3	-3.9	-0.8	3.6
Time to tail flick, vehicle, before self-admin	0.5	0.6	1.4	-0.5	-0.3	-0.4	-1.0	1.2
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	0.4	0.4	-0.1	0.2	0.1
Time to tail flick, test, before self-admin	4.0	3.9	6.2	-2.5	-2.4	2.0	-1.8	-0.5
Time to tail flick, test, after self-admin	1.0	1.0	1.8	-1.3	-1.2	0.8	-1.1	-0.1
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	2.4	1.2	1.0	-0.1	1.6	-0.8
Delta time to tail flick, test, before/after SA	1.8	1.6	2.2	1.5	1.5	-1.3	1.4	0.2
Tibia length	0.7	2.1	5.2	-1.5	-1.3	0.4	-2.3	1.0
Ambulatory time before self-admin	0.1	0.2	0.2	0.5	0.5	-0.2	0.4	-0.3
Ambulatory time after self-admin	2.7	3.0	4.2	1.9	2.0	-1.9	-0.6	1.7
Bone: tissue strength	0.2	0.2	0.5	0.4	0.3	0.0	0.7	-0.4
Total heroin consumption	1.4	1.7	3.9	-0.7	-0.6	-0.9	-1.7	2.0
Bone: trabecular number	0.6	0.9	2.6	-0.8	-0.6	-0.2	-1.6	1.0
Bone: trabecular spacing	0.4	0.5	1.2	0.7	0.5	0.0	1.1	-0.6
Bone: trabecular thickness	0.2	0.2	0.5	-0.0	0.1	-0.5	-0.6	0.7
Bone: trabecular tissue density	1.4	1.9	3.4	-1.0	-1.2	1.7	1.0	-1.8
Water consumed over 24 hours	3.3	4.0	6.4	-2.5	-2.5	2.0	-1.8	-0.5
Number of responses in last shaping day	1.0	1.0	2.9	0.8	0.7	-0.0	1.7	-1.0