Hub : Genes

Atcay

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression Atcay 0.31 0.16 3.6e-06 0.14 0.12 0.15 0.11 1.8e-04 3.9e-04 9.6e-05 6.3e-04
2 PL gene expression Atcay 0.15 0.09 0.0e+00 0.16 0.18 0.19 0.18 7.6e-17 7.9e-20 4.4e-20 9.9e-20
3 BLA gene expression Atcay 0.31 0.16 0.0e+00 0.35 0.34 0.35 0.35 2.6e-19 4.0e-19 1.3e-19 2.2e-19
4 OFC gene expression Atcay 0.15 0.1 5.8e-04 0.11 0.13 0.12 0.12 1.4e-03 4.7e-04 8.2e-04 9.8e-04
5 NAcc gene expression Atcay 0.33 0.2 0.0e+00 0.33 0.33 0.34 0.33 2.2e-39 4.3e-39 1.1e-40 2.5e-39
6 Brain gene expression Atcay 0.28 0.16 0.0e+00 0.22 0.2 0.21 0.22 2.7e-20 8.0e-19 4.2e-19 5.1e-20
7 IL gene expression Atcay 0.37 0.18 1.2e-06 0.17 0.15 0.17 0.16 6.2e-05 1.8e-04 6.7e-05 9.8e-05
8 pVTA gene expression Atcay 0.22 0.12 2.4e-10 0.23 0.22 0.22 0.22 2.0e-10 7.6e-10 8.5e-10 8.2e-10
9 Brain mRNA stability Atcay 0.14 0.09 4.9e-07 0.04 0.07 0.07 0.07 5.3e-05 3.0e-07 3.0e-07 2.9e-07
10 LHb mRNA stability Atcay 0.31 0.19 7.5e-03 0.12 0.12 0.12 0.11 9.7e-04 9.0e-04 9.2e-04 1.7e-03
11 PL mRNA stability Atcay 0.12 0.08 3.5e-07 0.05 0.07 0.07 0.06 2.6e-06 8.5e-08 8.5e-08 1.2e-07
12 IL mRNA stability Atcay 0.51 0.2 1.9e-03 0.08 0.02 0.08 0.07 5.4e-03 1.1e-01 6.7e-03 9.5e-03
13 NAcc mRNA stability Atcay 0.1 0.07 1.1e-04 0.03 0.03 0.03 0.03 1.1e-04 1.4e-04 2.0e-04 1.8e-04
14 NAcc intron excision ratio chr7_8498251_8501658 0.14 0.09 2.4e-06 0.06 0.05 0.05 0.06 1.9e-07 1.8e-06 3.5e-06 5.5e-07
15 NAcc intron excision ratio chr7_8493366_8498193 0.17 0.1 1.5e-07 0.07 0.06 0.06 0.07 1.2e-08 9.1e-08 1.1e-07 2.3e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.93.17.6-1.1-0.4-0.00.10.10.50.50.51.92.8-2.4-2.6-2.62.6-2.6
Area under the delay curve1.51.62.51.21.51.6-1.51.61.61.61.61.51.0-1.3-0.4-0.50.5-0.5
BMI with tail4.013.023.34.74.84.8-4.84.74.64.64.63.20.9-2.10.71.1-1.11.1
BMI without tail1.63.37.12.72.32.3-2.22.12.02.02.01.0-0.4-0.41.01.6-1.61.6
Body weight0.73.05.52.22.42.3-2.32.32.22.22.21.40.3-0.80.60.6-0.50.5
Weight adjusted by age0.60.71.91.10.60.6-0.60.40.40.40.4-0.2-0.80.40.81.4-1.41.4
Bone surface3.76.515.1-2.1-1.2-0.60.7-0.40.30.30.32.43.8-3.2-3.9-3.93.9-3.9
Bone volume3.86.515.1-2.1-1.2-0.60.7-0.40.30.30.32.43.8-3.1-3.9-3.93.9-3.9
Breakpoint value in progressive ratio session3.74.16.9-2.0-2.4-2.62.5-2.6-2.5-2.5-2.5-2.4-1.51.80.40.6-0.60.6
Number of licking bursts0.70.81.90.60.40.1-0.20.10.00.00.0-0.8-1.41.11.41.4-1.41.4
Context. condit. distance diff. score0.20.20.40.60.70.6-0.60.60.70.70.70.3-0.0-0.10.20.2-0.20.2
Locomotion velocity, session 10.91.02.0-1.2-1.0-0.70.8-0.7-0.6-0.6-0.60.41.1-0.8-1.4-1.41.4-1.4
Locomotion distance, session 11.11.43.4-0.9-0.5-0.20.3-0.20.00.00.01.11.7-1.5-1.8-1.81.8-1.8
Locomotion velocity, session 23.03.56.8-2.6-2.3-2.02.1-1.9-1.7-1.7-1.7-0.11.3-0.7-2.1-2.12.1-2.1
Locomotion distance, session 21.82.54.6-2.0-1.7-1.41.5-1.3-1.0-1.0-1.00.41.6-1.1-2.1-2.12.1-2.1
Locomotion velocity, session 33.84.47.7-2.5-2.7-2.72.8-2.8-2.8-2.8-2.8-2.1-0.91.5-0.2-0.20.2-0.2
Locomotion distance, session 30.00.00.10.1-0.00.00.0-0.1-0.2-0.2-0.2-0.2-0.20.30.20.2-0.20.2
Stereotopy head waving bouts, day 32.93.46.3-2.5-2.5-2.42.4-2.4-2.2-2.2-2.2-1.3-0.00.6-1.0-1.01.0-1.0
Stereotopy head waving duration, day 33.34.07.2-2.6-2.7-2.72.7-2.6-2.5-2.5-2.5-1.6-0.30.9-0.8-0.80.8-0.8
Locomotion velocity, session 70.50.61.2-1.1-1.0-1.01.0-0.9-0.9-0.9-0.9-0.30.20.0-0.6-0.60.6-0.6
Locomotion distance, session 70.30.30.80.50.30.3-0.30.20.00.00.0-0.5-0.80.70.90.9-0.90.9
Stereotopy head waving bouts, day 70.80.92.0-0.6-0.2-0.00.10.00.30.30.31.01.4-1.2-1.4-1.41.4-1.4
Stereotopy head waving duration, day 70.91.12.7-1.0-0.6-0.50.5-0.4-0.0-0.0-0.00.81.4-1.2-1.7-1.71.7-1.7
Locomotion velocity, session 81.51.84.1-1.4-0.9-0.70.7-0.6-0.2-0.2-0.20.91.7-1.4-2.0-2.02.0-2.0
Locomotion distance, session 80.10.20.5-0.5-0.4-0.30.3-0.3-0.2-0.2-0.20.30.5-0.4-0.7-0.70.7-0.7
Degree of sensitization distance0.20.20.50.50.60.6-0.60.60.70.70.70.50.2-0.40.00.0-0.00.0
Degree of sensitization stereotypy1.81.93.30.91.31.4-1.41.51.61.61.61.81.5-1.7-1.0-1.01.0-1.0
Conditioned locomotion1.61.93.82.01.61.4-1.51.41.11.11.1-0.0-1.10.61.61.6-1.61.6
Cocaine response after cond. corrected3.64.08.42.92.72.5-2.52.42.12.12.10.7-0.90.11.81.8-1.81.8
Cocaine response after cond. not corrected4.04.49.13.02.82.6-2.62.52.12.12.10.7-1.00.21.91.9-1.91.9
Cocaine response before conditioning0.30.40.8-0.9-0.9-0.80.8-0.7-0.7-0.7-0.7-0.20.3-0.1-0.6-0.60.6-0.6
Saline control response0.10.10.20.40.30.3-0.30.20.10.10.1-0.1-0.40.30.50.5-0.50.5
Bone: connectivity density1.32.15.2-0.40.10.5-0.40.60.80.80.81.82.3-2.0-2.0-2.02.0-2.0
Bone: cortical apparent density0.60.91.91.01.21.0-1.11.11.41.41.40.70.1-0.50.20.2-0.20.2
Bone: cortical area1.11.63.10.10.60.8-0.80.91.31.31.31.71.8-1.8-1.4-1.41.4-1.4
Bone: cortical porosity0.40.51.0-1.0-0.9-0.80.8-0.8-0.6-0.6-0.6-0.10.5-0.2-0.8-0.80.8-0.8
Bone: cortical porosity0.50.61.3-0.6-0.3-0.20.2-0.10.20.20.20.71.1-1.0-1.2-1.21.2-1.2
Bone: cortical thickness0.91.52.61.01.31.3-1.41.41.61.61.61.51.1-1.3-0.6-0.60.6-0.6
Bone: cortical thickness0.30.30.80.30.1-0.00.0-0.1-0.3-0.3-0.3-0.6-0.90.80.80.8-0.80.8
Bone: cortical tissue density0.50.61.40.91.00.9-0.90.91.21.21.20.60.0-0.30.20.2-0.20.2
Condit. Reinf. active minus inactive responses2.52.85.0-2.2-2.2-2.22.2-2.2-2.2-2.2-2.2-1.5-0.40.9-0.4-0.40.4-0.4
Condit. Reinf. active-inactive response ratio1.61.72.8-1.3-1.5-1.51.6-1.6-1.7-1.7-1.7-1.6-1.11.30.50.4-0.50.5
Condit. Reinf. active responses2.32.85.9-2.4-2.3-2.12.2-2.1-1.9-1.9-1.9-0.80.40.1-1.3-1.21.3-1.3
Condit. Reinf. inactive responses1.01.22.3-1.4-1.1-0.91.0-0.9-0.7-0.7-0.70.31.1-0.8-1.5-1.41.5-1.5
Incentive salience index mean1.51.83.8-2.0-1.8-1.61.7-1.6-1.4-1.4-1.4-0.50.5-0.0-1.1-1.11.1-1.1
Condit. Reinf. lever presses1.31.84.1-1.0-0.4-0.10.2-0.10.30.30.31.32.0-1.7-2.0-2.02.0-2.0
Condit. Reinf. active minus inactive responses2.02.43.9-1.3-1.6-1.81.7-1.8-1.9-1.9-1.9-2.0-1.51.70.80.8-0.80.8
Condit. Reinf. active-inactive response ratio1.31.33.00.4-0.1-0.30.2-0.4-0.7-0.7-0.7-1.4-1.71.61.61.6-1.61.6
Condit. Reinf. active responses1.52.13.6-1.7-1.8-1.91.9-1.9-1.9-1.9-1.9-1.5-0.71.0-0.0-0.00.0-0.0
Condit. Reinf. inactive responses0.91.12.3-1.5-1.4-1.31.3-1.2-1.1-1.1-1.1-0.40.4-0.0-0.9-0.90.9-0.9
Condit. Reinf. lever presses1.82.54.1-1.4-1.7-1.81.8-1.9-2.0-2.0-2.0-1.9-1.31.60.60.6-0.60.6
Condit. Reinf. lever reinforcers received1.31.83.1-1.3-1.6-1.61.6-1.6-1.8-1.8-1.8-1.5-0.91.20.30.3-0.30.3
Conditioned reinforcement - actives1.61.63.2-1.6-1.8-1.71.7-1.7-1.6-1.6-1.6-1.1-0.30.6-0.5-0.20.2-0.2
Conditioned reinforcement - inactives0.60.71.71.01.10.8-0.90.80.60.60.6-0.2-0.80.61.30.9-0.70.7
Conditioned locomotion5.16.110.7-3.1-3.2-3.33.3-3.3-3.2-3.2-3.2-2.4-1.01.6-0.3-0.20.2-0.2
Patch foraging indifference point 0 sec0.10.20.30.30.50.4-0.50.60.60.60.60.50.4-0.4-0.1-0.40.4-0.4
Patch foraging indifference point AUC0.70.81.4-0.9-1.1-1.11.1-1.2-1.1-1.1-1.1-0.9-0.60.7-0.00.3-0.40.4
Delay disc. indifference point, 0s delay6.36.811.52.02.52.8-2.82.93.13.13.13.42.7-3.0-1.6-1.71.8-1.8
Delay disc. indifference point, 16s delay0.10.10.20.30.40.4-0.40.50.40.40.40.40.3-0.4-0.2-0.20.2-0.2
Delay disc. indifference point, 2s delay4.24.67.32.12.42.6-2.62.62.72.72.72.61.7-2.2-0.8-0.80.8-0.8
Delay disc. indifference point, 24s delay0.40.40.70.80.80.9-0.70.80.70.70.70.60.2-0.5-0.10.3-0.30.3
Delay disc. indifference point, 4s delay1.31.42.60.60.91.1-1.01.21.21.21.21.61.5-1.6-1.1-1.11.1-1.1
Delay disc. indifference point, 8s delay0.60.71.41.21.11.1-1.11.00.90.90.90.4-0.1-0.00.70.5-0.50.5
Indifference point function ln k0.10.20.40.50.60.5-0.60.60.60.60.60.30.1-0.10.30.10.0-0.0
Indifference point function log k0.10.20.40.50.60.5-0.60.60.60.60.60.30.1-0.10.30.10.0-0.0
Patch foraging total patch changes 0 sec0.10.10.20.30.50.4-0.40.50.50.50.50.30.2-0.20.1-0.30.2-0.2
Patch foraging total patch changes 12 sec0.40.51.21.10.70.6-0.60.60.40.40.4-0.1-0.70.40.90.9-1.11.1
Patch foraging total patch changes 18 sec0.60.81.5-1.1-1.2-1.21.2-1.2-1.1-1.1-1.1-0.9-0.50.6-0.10.1-0.10.1
Patch foraging total patch changes 24 sec0.10.10.2-0.3-0.4-0.30.3-0.3-0.4-0.4-0.4-0.00.1-0.1-0.3-0.10.0-0.0
Patch foraging total patch changes 6 sec0.10.20.4-0.6-0.4-0.60.5-0.5-0.4-0.4-0.4-0.4-0.10.30.1-0.30.3-0.3
Patch foraging time to switch 0 sec1.52.34.01.01.41.5-1.61.71.71.71.72.01.7-1.8-1.0-1.21.3-1.3
Patch foraging water rate 0 sec0.71.12.60.40.1-0.20.2-0.3-0.5-0.5-0.5-1.2-1.61.41.51.6-1.61.6
Patch foraging water rate 12 sec1.21.83.61.81.41.2-1.21.10.90.90.9-0.2-1.30.81.61.7-1.91.9
Patch foraging water rate 18 sec2.53.37.90.80.1-0.30.3-0.4-0.8-0.8-0.8-2.1-2.82.52.52.6-2.82.8
Patch foraging water rate 24 sec2.73.79.81.61.10.5-0.70.5-0.1-0.1-0.1-1.8-2.82.43.12.9-2.82.8
Patch foraging water rate 6 sec1.42.04.30.0-0.5-0.70.6-0.8-1.2-1.2-1.2-1.9-2.12.01.81.7-1.81.8
Seeking ratio, delayed vs. immediate footshock3.13.67.1-2.7-2.6-2.42.5-2.4-2.3-2.3-2.3-1.30.00.6-0.9-1.11.0-1.0
Distance traveled before self-admin0.20.20.50.30.40.5-0.50.50.60.60.60.70.6-0.6-0.4-0.50.2-0.2
Distance traveled after self-admin0.60.71.2-1.1-1.1-1.01.0-1.1-1.0-1.0-1.0-0.50.10.3-0.4-0.70.4-0.4
Extensor digitorum longus weight2.911.321.64.64.64.4-4.44.34.04.04.02.0-0.3-0.72.02.2-2.12.1
Bone: elastic displacement0.20.20.4-0.6-0.6-0.60.6-0.6-0.6-0.6-0.6-0.30.00.2-0.2-0.20.2-0.2
Bone: elastic work0.30.30.60.10.40.4-0.40.50.60.60.60.80.8-0.8-0.6-0.60.6-0.6
Bone: endosteal estimation0.30.61.10.20.50.6-0.60.70.90.90.91.11.0-1.1-0.8-0.80.8-0.8
Bone: endosteal perimeter0.51.02.0-1.2-0.9-0.80.8-0.7-0.3-0.3-0.30.41.1-0.8-1.4-1.41.4-1.4
Epididymis fat weight0.30.61.0-0.2-0.5-0.60.6-0.7-0.8-0.8-0.8-1.0-1.01.00.70.8-0.80.8
Delta time in closed arm before/after self-admin2.32.36.41.51.00.8-0.80.70.20.20.2-1.0-1.91.52.22.5-2.32.3
Delta time in open arm before/after self-admin0.90.91.60.91.21.1-1.21.21.31.31.31.10.7-0.8-0.2-0.50.4-0.4
Diff in mean of infusions in LGA sessions1.01.12.0-1.2-1.3-1.41.4-1.4-1.3-1.3-1.3-1.1-0.50.8-0.0-0.1-0.10.1
Delay discount exponential model param1.41.42.3-1.2-1.4-1.51.5-1.5-1.5-1.5-1.5-1.4-0.91.20.40.4-0.40.4
Extinction: sum of active levers before priming1.71.73.0-0.6-1.0-1.21.1-1.2-1.3-1.3-1.3-1.7-1.61.61.11.3-1.21.2
Active lever presses in extinction session 62.01.93.6-1.7-1.9-1.91.9-1.9-1.7-1.7-1.7-1.2-0.40.7-0.5-0.30.2-0.2
Bone: final force1.32.13.80.71.21.3-1.31.41.71.71.71.91.7-1.8-1.2-1.21.2-1.2
Bone: final moment1.11.83.20.61.01.2-1.21.31.51.51.51.81.6-1.7-1.1-1.11.1-1.1
Food consumed during 24 hour testing period0.30.40.60.80.80.8-0.80.80.80.80.80.50.1-0.30.20.2-0.20.2
Glucose0.71.12.11.41.41.4-1.41.41.21.21.20.80.2-0.40.40.4-0.40.4
Heart weight0.50.71.1-0.2-0.6-0.60.7-0.7-0.9-0.9-0.9-1.0-1.01.00.70.7-0.90.9
Delay discount hyperbolic model param1.92.13.2-1.4-1.7-1.81.8-1.8-1.8-1.8-1.8-1.7-1.11.40.40.5-0.50.5
Intermittent access intake day 1-15 change4.74.67.8-2.5-2.6-2.82.7-2.7-2.8-2.8-2.8-2.4-1.41.90.30.3-0.10.1
Intermittent access intake escalation5.65.59.3-2.0-2.3-2.72.6-2.7-2.9-2.9-2.9-3.0-2.32.71.31.3-1.11.1
Intermittent access intake escalation 26.56.410.0-2.2-2.6-2.92.9-3.0-3.2-3.2-3.2-3.2-2.32.71.11.3-1.11.1
Intermitt. access day 1 inactive lever presses0.70.71.4-0.3-0.5-0.60.6-0.7-0.9-0.9-0.9-1.1-1.11.20.90.8-0.80.8
Intermitt. access day 15 inactive lever presses0.40.51.0-0.5-0.5-0.70.7-0.7-0.7-0.7-0.7-1.0-0.80.90.60.4-0.30.3
Intermitt. access escalation Index1.10.92.2-0.10.20.4-0.30.40.80.80.81.31.5-1.5-1.4-1.01.2-1.2
Intermittent access day 1 total infusions0.10.10.20.10.30.2-0.30.30.40.40.40.30.2-0.3-0.1-0.10.2-0.2
Intermittent access day 15 total infusions1.51.62.9-1.2-1.3-1.61.5-1.5-1.5-1.5-1.5-1.7-1.31.40.70.8-0.50.5
Intermittent access terminal intake (last 3 days)0.70.81.4-1.0-1.1-1.21.2-1.2-1.0-1.0-1.0-0.9-0.50.6-0.10.1-0.10.1
Intermittent access total infusions0.20.20.5-0.4-0.3-0.50.4-0.4-0.4-0.4-0.4-0.7-0.60.60.40.3-0.20.2
Intermittent access day 1 locomotion0.20.20.6-0.5-0.4-0.60.5-0.5-0.5-0.5-0.5-0.8-0.60.60.40.3-0.10.1
Intermittent access day 15 total locomotion2.42.64.4-1.9-1.8-2.12.0-2.0-2.0-2.0-2.0-2.0-1.21.50.50.2-0.20.2
Intermittent access total locomotion0.70.81.5-1.2-1.0-1.21.1-1.1-1.0-1.0-1.0-1.0-0.50.70.1-0.10.1-0.1
Intermittent access standard deviation2.42.54.0-1.6-1.8-1.91.9-2.0-2.0-2.0-2.0-1.9-1.31.50.40.8-0.50.5
Left kidney weight0.20.51.8-0.6-0.5-0.20.3-0.3-0.0-0.0-0.00.71.0-1.0-1.4-0.80.8-0.8
Right kidney weight0.92.54.9-2.1-2.2-2.12.1-2.1-2.0-2.0-2.0-1.1-0.10.6-0.8-0.60.5-0.5
Cocaine induced anxiety0.81.02.0-1.2-1.2-0.91.0-0.9-0.7-0.7-0.70.31.0-0.7-1.4-1.21.1-1.1
Post-drug Anxiety1.01.13.7-1.0-1.0-0.60.7-0.6-0.4-0.4-0.40.81.5-1.3-1.9-1.31.3-1.3
Baseline Anxiety0.20.20.50.10.0-0.10.1-0.1-0.2-0.2-0.2-0.5-0.70.60.60.7-0.70.7
Tail length2.16.510.8-2.7-3.1-3.23.2-3.3-3.3-3.3-3.3-2.9-1.72.30.50.4-0.40.4
Length with tail1.24.48.3-2.9-2.7-2.82.7-2.7-2.6-2.6-2.6-1.9-0.41.2-0.4-0.90.9-0.9
Length without tail0.40.92.7-1.0-0.4-0.40.3-0.2-0.0-0.0-0.00.61.2-0.8-1.1-1.61.6-1.6
Times rat made contact with spout0.30.40.80.70.60.5-0.50.40.20.20.2-0.3-0.70.50.90.9-0.90.9
Lifetime Intake0.00.00.1-0.3-0.2-0.30.3-0.2-0.1-0.1-0.1-0.3-0.20.10.00.2-0.10.1
Liver weight, left1.62.65.42.32.12.2-2.12.01.91.91.91.1-0.1-0.50.81.1-1.01.0
Liver weight, right1.11.83.21.61.71.8-1.81.81.71.71.71.30.6-1.00.10.0-0.00.0
Locomotor activity2.43.88.7-2.9-2.5-2.52.5-2.3-2.0-2.0-2.0-0.90.70.1-1.4-1.81.7-1.7
Locomotor testing distance1.32.24.9-2.2-2.0-2.01.9-1.9-1.6-1.6-1.6-0.80.30.3-0.9-1.11.1-1.1
Locomotor testing rearing0.10.10.20.0-0.1-0.20.2-0.2-0.2-0.2-0.2-0.4-0.50.40.30.3-0.40.4
Locomotion in novel chamber0.50.61.0-0.3-0.7-0.60.7-0.8-0.9-0.9-0.9-1.0-0.80.80.60.7-0.80.8
Locomotion in novel chamber post-restriction0.50.51.0-0.8-1.0-1.01.0-1.0-1.0-1.0-1.0-0.7-0.30.4-0.10.1-0.00.0
Fecal boli incidents, locomotor time 11.41.53.01.71.61.4-1.51.31.31.31.30.3-0.60.21.21.2-1.21.2
Change in fecal boli incidents, locomotor task1.00.92.2-1.0-0.8-0.60.6-0.6-0.3-0.3-0.30.61.2-0.9-1.5-1.41.4-1.4
Time >=10cm from walls, locomotor time 10.70.71.40.10.40.5-0.50.60.70.70.71.11.1-1.2-1.0-1.01.0-1.0
Bouts of movement, locomotor time 10.10.10.2-0.3-0.3-0.40.4-0.4-0.4-0.4-0.4-0.5-0.40.40.20.2-0.20.2
Total resting periods, locomotor time 10.10.10.3-0.5-0.5-0.50.5-0.5-0.4-0.4-0.4-0.4-0.20.2-0.1-0.10.1-0.1
Rest time, locomotor task time 10.10.10.3-0.5-0.5-0.50.5-0.5-0.3-0.3-0.3-0.00.2-0.1-0.5-0.40.4-0.4
Distance moved, locomotor task time 10.90.91.80.10.50.6-0.60.70.80.80.81.21.3-1.3-1.0-1.21.3-1.3
Vertical activity count, locomotor time 10.00.00.20.30.20.2-0.20.20.10.10.1-0.1-0.20.20.40.2-0.20.2
Time >=10cm from walls, locomotor time 20.70.81.51.21.21.1-1.11.11.01.01.00.4-0.30.00.70.7-0.70.7
Bouts of movement, locomotor time 20.60.71.5-1.0-0.8-0.60.7-0.6-0.4-0.4-0.40.30.9-0.7-1.2-1.21.2-1.2
Total resting periods, locomotor time 20.70.81.8-1.0-0.7-0.60.6-0.5-0.4-0.4-0.40.51.1-0.8-1.3-1.31.3-1.3
Rest time, locomotor task time 20.40.51.0-1.0-0.8-0.80.8-0.7-0.5-0.5-0.50.00.5-0.4-1.0-0.80.8-0.8
Distance moved, locomotor task time 20.60.71.31.11.10.9-1.00.90.80.80.80.1-0.50.31.00.8-0.80.8
Vertical activity count, locomotor time 21.01.12.21.31.10.8-0.90.70.70.70.7-0.3-1.10.81.51.4-1.41.4
Light reinforcement 13.56.311.5-3.4-3.3-3.33.3-3.2-3.2-3.2-3.2-2.2-0.61.4-0.5-0.60.7-0.7
Light reinforcement 21.11.52.9-1.7-1.5-1.71.6-1.5-1.4-1.4-1.4-1.1-0.30.7-0.2-0.50.5-0.5
Bone: marrow area0.30.61.10.20.50.6-0.60.70.90.90.91.11.0-1.0-0.7-0.70.7-0.7
Bone: maximum diameter0.91.63.1-1.7-1.3-1.21.2-1.0-0.6-0.6-0.60.41.3-0.9-1.8-1.81.8-1.8
Bone: maximum force1.12.03.30.91.31.4-1.41.51.81.81.81.81.5-1.7-0.9-0.90.9-0.9
Bone: maximum moment1.01.72.90.81.21.2-1.31.31.71.71.71.71.4-1.6-0.9-0.90.9-0.9
Mean time between licks in bursts2.73.96.3-2.1-2.3-2.52.4-2.5-2.5-2.5-2.5-2.3-1.41.80.50.5-0.50.5
Mean num. licks in bursts0.10.10.4-0.0-0.00.2-0.10.20.10.10.10.50.6-0.5-0.5-0.50.5-0.5
Cd content in liver0.10.10.20.30.40.4-0.50.50.50.50.50.50.3-0.4-0.1-0.10.1-0.1
Co content in liver0.50.61.0-0.6-0.7-0.80.8-0.9-0.9-0.9-0.9-1.0-0.80.90.50.4-0.40.4
Cu content in liver0.60.71.7-0.30.10.2-0.20.30.50.50.51.01.3-1.2-1.1-1.31.3-1.3
Fe content in liver0.20.20.60.2-0.0-0.10.1-0.1-0.2-0.2-0.2-0.5-0.70.60.60.7-0.70.7
K content in liver0.60.61.6-0.5-0.2-0.00.10.00.20.20.20.91.2-1.0-1.3-1.11.1-1.1
Mg content in liver0.90.92.4-0.6-0.3-0.00.10.00.20.20.21.11.4-1.3-1.6-1.41.4-1.4
Mn content in liver2.63.07.0-1.9-1.4-1.11.1-0.9-0.5-0.5-0.51.12.2-1.7-2.6-2.52.5-2.5
Na content in liver1.01.01.80.60.91.0-1.01.11.21.21.21.31.1-1.2-0.7-0.70.7-0.7
Rb content in liver1.01.22.70.00.40.6-0.60.70.90.90.91.51.6-1.6-1.5-1.31.3-1.3
Se content in liver0.10.10.3-0.5-0.5-0.40.5-0.4-0.4-0.4-0.4-0.10.1-0.0-0.3-0.30.3-0.3
Sr content in liver0.80.81.80.40.2-0.0-0.0-0.1-0.3-0.3-0.3-0.9-1.21.21.31.3-1.31.3
Zn content in liver2.83.15.7-0.6-1.2-1.41.4-1.6-1.9-1.9-1.9-2.3-2.32.41.61.7-1.71.7
Bone: minimum diameter0.30.61.3-0.4-0.10.0-0.00.10.40.40.40.91.1-1.0-1.1-1.11.1-1.1
Time in familiar zone, hab. session 11.51.42.5-1.2-1.4-1.51.4-1.5-1.6-1.6-1.6-1.4-0.91.10.30.3-0.30.3
Time in novel zone, hab. session 11.41.42.50.40.80.9-0.91.01.21.21.21.61.5-1.6-1.2-1.21.2-1.2
Total zone transitions, hab. session 11.01.52.6-1.5-1.3-1.11.1-1.0-0.8-0.8-0.80.31.2-0.8-1.6-1.61.6-1.6
Total locomotion distance, hab. session 12.13.06.4-2.0-1.5-1.21.2-1.0-0.8-0.8-0.80.92.1-1.6-2.5-2.52.5-2.5
Locomotion velocity, hab. session 11.72.54.3-2.0-1.7-1.41.5-1.3-1.1-1.1-1.10.31.5-1.0-2.1-2.12.1-2.1
Time in familiar zone, hab. session 24.74.88.0-2.0-2.5-2.62.6-2.7-2.8-2.8-2.8-2.7-1.82.20.80.8-0.80.8
Time in novel zone, hab. session 23.83.86.11.62.02.2-2.22.22.42.42.42.51.8-2.2-1.0-1.01.0-1.0
Total zone transitions, hab. session 21.31.73.9-0.30.20.4-0.40.60.70.70.71.72.0-1.9-1.8-1.81.8-1.8
Total locomotion distance, hab. session 20.91.22.1-1.4-1.2-1.01.0-0.9-0.9-0.9-0.90.21.1-0.7-1.4-1.41.4-1.4
Locomotion velocity, hab. session 21.21.63.2-1.5-1.2-1.01.0-0.9-0.7-0.7-0.70.51.4-1.0-1.8-1.81.8-1.8
Novel to familiar place preference ratio3.63.76.41.31.82.0-2.02.12.32.32.32.52.1-2.3-1.3-1.31.3-1.3
Novelty place preference2.52.54.40.91.31.6-1.51.61.81.81.82.11.8-2.0-1.3-1.31.3-1.3
Time in novel zone, NPP test2.52.64.51.11.51.7-1.61.71.91.91.92.11.8-2.0-1.2-1.21.2-1.2
Total zone transitions, NPP test0.30.41.0-0.2-0.00.1-0.10.20.20.20.20.81.0-0.9-0.9-0.90.9-0.9
Total locomotion distance, NPP test0.60.92.1-0.3-0.10.2-0.10.30.30.30.31.11.4-1.3-1.4-1.41.4-1.4
Locomotion velocity, NPP test0.50.81.8-0.6-0.3-0.10.2-0.00.00.00.00.91.3-1.1-1.3-1.31.3-1.3
Intraocular pressure0.91.23.20.60.0-0.00.1-0.2-0.5-0.5-0.5-1.1-1.71.41.41.7-1.81.8
Delta distance traveled before/after self-admin1.01.11.9-1.3-1.4-1.41.3-1.3-1.3-1.3-1.3-0.9-0.30.6-0.2-0.50.4-0.4
Delta ambulatory time before/after self-admin1.11.22.3-1.5-1.5-1.41.4-1.4-1.3-1.3-1.3-0.60.10.2-0.7-0.60.6-0.6
Parametrial fat weight0.30.71.2-0.9-0.9-1.01.0-1.0-1.0-1.0-1.0-1.1-0.70.90.40.2-0.10.1
Pavlov. Cond. lever latency0.60.81.80.40.1-0.10.0-0.1-0.3-0.3-0.3-1.0-1.41.21.31.4-1.31.3
Pavlov. Cond. magazine entry latency1.72.23.8-1.7-1.9-2.01.9-1.9-1.9-1.9-1.9-1.6-0.91.20.10.1-0.10.1
Pavlov. Cond. change in total contacts0.00.00.1-0.3-0.3-0.20.2-0.2-0.3-0.3-0.3-0.10.1-0.0-0.2-0.10.2-0.2
Pavlov. Cond. index score0.40.50.9-0.9-0.8-0.70.7-0.6-0.5-0.5-0.50.10.6-0.4-0.9-0.90.9-0.9
Pavlov. Cond. latency score0.60.81.7-1.1-0.8-0.70.7-0.6-0.4-0.4-0.40.41.0-0.8-1.3-1.31.3-1.3
Pavlov. Cond. lever contacts0.91.12.7-0.8-0.4-0.10.2-0.10.10.10.11.01.5-1.3-1.6-1.61.6-1.6
Pavlov. Cond. magazine entry number0.40.40.80.80.90.9-0.90.90.80.80.80.60.2-0.40.10.1-0.10.1
Pavlov. Cond. intertrial magazine entries0.40.51.20.1-0.2-0.30.3-0.4-0.5-0.5-0.5-0.9-1.11.01.01.0-1.01.0
Pavlov. Cond. lever-magazine prob. diff.0.60.71.4-1.2-1.1-1.01.0-0.9-0.8-0.8-0.8-0.10.5-0.2-0.9-0.90.9-0.9
Pavlov. Cond. response bias0.60.81.4-1.1-1.2-1.11.2-1.1-1.1-1.1-1.1-0.7-0.20.4-0.3-0.30.3-0.3
Pavlov. Cond. lever latency0.60.81.41.11.21.1-1.21.11.11.11.10.70.1-0.40.30.3-0.30.3
Pavlov. Cond. magazine entry latency0.40.41.0-1.0-0.9-0.80.8-0.8-0.6-0.6-0.6-0.30.3-0.0-0.6-0.60.6-0.6
Pavlov. Cond. change in total contacts0.60.81.5-1.0-1.2-1.11.1-1.2-1.2-1.2-1.2-0.9-0.40.70.00.0-0.00.0
Pavlov. Cond. index score0.60.81.5-1.2-1.2-1.21.2-1.2-1.1-1.1-1.1-0.8-0.20.5-0.2-0.20.2-0.2
Pavlov. Cond. latency score0.60.71.4-1.2-1.2-1.11.1-1.1-1.0-1.0-1.0-0.60.10.2-0.5-0.50.5-0.5
Pavlov. Cond. lever contacts0.60.81.4-0.9-1.1-1.11.1-1.1-1.2-1.2-1.2-1.0-0.50.80.10.1-0.10.1
Pavlov. Cond. magazine entry number0.60.71.61.21.21.1-1.11.10.90.90.90.4-0.3-0.10.60.6-0.60.6
Pavlov. Cond. intertrial magazine entries0.40.50.90.90.90.7-0.70.70.60.60.6-0.0-0.70.40.90.9-0.90.9
Pavlov. Cond. lever-magazine prob. diff.0.60.81.5-1.2-1.2-1.21.2-1.2-1.1-1.1-1.1-0.7-0.00.4-0.4-0.40.4-0.4
Pavlov. Cond. response bias1.31.83.0-1.4-1.7-1.71.7-1.7-1.7-1.7-1.7-1.5-0.81.10.10.1-0.10.1
Time in closed arm before self-admin1.31.42.40.40.80.9-0.91.01.21.21.21.61.5-1.5-1.1-1.51.4-1.4
Time in closed arm after self-admin0.00.00.10.1-0.2-0.00.1-0.1-0.3-0.3-0.3-0.1-0.20.20.10.3-0.20.2
Time in open arm before self-admin0.90.91.6-0.9-1.1-1.11.1-1.1-1.3-1.3-1.3-1.2-0.70.90.30.4-0.40.4
Time in open arm after self-admin0.40.51.10.81.10.9-0.90.90.90.90.90.3-0.0-0.10.50.2-0.30.3
Bone: periosteal estimation0.91.83.5-0.00.50.7-0.70.81.31.31.31.71.9-1.9-1.6-1.61.6-1.6
Bone: periosteal perimeter0.71.22.9-1.0-0.5-0.40.3-0.20.20.20.21.01.6-1.3-1.7-1.71.7-1.7
Bone: post-yield work0.40.61.10.91.00.9-0.90.91.11.11.10.70.2-0.40.10.1-0.10.1
Progressive ratio test 1 active lever presses0.20.20.40.50.50.3-0.40.40.30.30.3-0.1-0.50.20.50.6-0.50.5
Progressive ratio test 1 breakpoint0.20.20.30.60.50.4-0.50.50.50.50.50.0-0.30.10.40.5-0.40.4
Progressive ratio test 1 inactive lever presses0.00.00.0-0.1-0.0-0.10.1-0.0-0.0-0.0-0.0-0.1-0.00.00.0-0.00.1-0.1
Progressive ratio test 2 active lever presses0.30.30.6-0.2-0.4-0.50.5-0.5-0.6-0.6-0.6-0.8-0.80.70.50.6-0.60.6
Progressive ratio test 2 breakpoint0.20.20.4-0.5-0.6-0.60.6-0.6-0.6-0.6-0.6-0.5-0.30.3-0.10.2-0.20.2
Progressive ratio test 2 inactive lever presses0.00.00.1-0.3-0.3-0.30.3-0.2-0.1-0.1-0.1-0.10.0-0.0-0.2-0.20.2-0.2
Incentive Sensitization - Responses0.40.40.7-0.2-0.6-0.60.6-0.7-0.7-0.7-0.7-0.8-0.80.70.40.6-0.70.7
Incentive Sensitization - Breakpoint0.40.40.6-0.3-0.7-0.60.7-0.7-0.8-0.8-0.8-0.7-0.60.60.10.4-0.60.6
Sum of active levers in priming session hrs 5-60.00.00.20.10.1-0.1-0.0-0.10.00.00.0-0.2-0.30.20.20.4-0.20.2
Progressive ratio0.30.30.80.80.50.6-0.50.40.30.30.3-0.1-0.50.30.60.9-0.90.9
Food seeking constrained by brief footshock0.10.10.2-0.2-0.4-0.30.3-0.3-0.5-0.5-0.5-0.1-0.10.1-0.20.1-0.10.1
Seeking ratio, punishment vs. effort0.10.20.4-0.6-0.4-0.50.4-0.3-0.3-0.3-0.30.00.2-0.1-0.4-0.50.6-0.6
Retroperitoneal fat weight0.30.92.01.21.41.1-1.21.21.21.21.20.2-0.40.21.10.7-0.50.5
Reaction time number correct0.81.12.41.41.00.9-0.90.80.50.50.5-0.3-1.10.71.31.5-1.61.6
Reaction time mean minus median0.40.61.3-1.1-1.1-1.01.1-1.1-0.9-0.9-0.9-0.6-0.10.2-0.5-0.30.2-0.2
Reaction time mean minus median AUC0.91.13.0-0.8-0.3-0.10.2-0.10.40.40.41.11.6-1.4-1.7-1.51.5-1.5
Reaction time num false alarms0.10.10.40.40.20.2-0.20.10.00.00.0-0.2-0.50.30.40.6-0.70.7
Reaction time num false alarms AUC0.30.41.30.70.40.3-0.30.20.10.10.1-0.4-0.90.60.81.1-1.11.1
Reaction time trials correct on left0.81.12.41.41.00.9-0.90.80.50.50.5-0.3-1.10.71.31.5-1.61.6
Reaction time trials on left0.71.02.21.41.00.9-0.90.80.60.60.6-0.2-1.00.61.21.4-1.51.5
Reaction time mean0.50.71.7-0.4-0.2-0.00.10.00.40.40.40.91.2-1.1-1.3-1.31.1-1.1
Reaction time mean AUC0.50.71.6-0.4-0.00.1-0.00.10.50.50.50.91.2-1.1-1.2-1.21.1-1.1
Median of all reaction times0.71.01.90.10.40.5-0.50.61.01.01.01.31.3-1.4-1.2-1.31.1-1.1
Reaction time omissions0.20.20.6-0.8-0.6-0.70.6-0.6-0.4-0.4-0.4-0.20.2-0.0-0.5-0.40.4-0.4
Reaction time false alarm rate0.00.00.00.10.00.1-0.00.00.10.10.10.20.1-0.2-0.2-0.00.0-0.0
Reaction time premature initiation rate1.01.42.6-0.8-1.0-1.31.1-1.2-1.4-1.4-1.4-1.6-1.31.51.00.7-0.70.7
Reaction time premature initiations1.41.94.2-0.1-0.5-0.90.7-0.8-1.2-1.2-1.2-1.9-2.02.01.81.6-1.61.6
Std. dev. reaction times0.20.30.9-0.8-0.7-0.60.7-0.6-0.2-0.2-0.20.10.5-0.5-1.0-0.70.6-0.6
Reaction time trials completed0.71.02.21.41.00.9-0.90.80.60.60.6-0.2-1.00.61.21.4-1.51.5
Reaction time trials AUC0.91.33.01.41.00.8-0.80.80.50.50.5-0.4-1.30.91.51.6-1.71.7
Run reversals in cocaine runway, females0.60.61.0-0.9-1.0-0.70.8-0.7-0.8-0.8-0.80.10.6-0.4-1.0-1.00.7-0.7
Run reversals in cocaine runway, males0.90.81.7-1.2-1.3-1.11.2-1.1-1.1-1.1-1.1-0.20.4-0.2-0.9-0.60.6-0.6
Latency to leave start box in cocaine runway1.21.32.6-1.6-1.2-1.21.1-1.0-0.6-0.6-0.60.21.1-0.7-1.5-1.51.5-1.5
Latency to leave start box in cocaine runway, F1.71.94.7-0.8-0.3-0.20.20.00.50.50.51.42.0-1.9-2.2-2.02.0-2.0
Latency to leave start box in cocaine runway, M2.62.54.4-1.2-1.6-1.71.7-1.8-1.8-1.8-1.8-2.1-1.61.91.01.0-1.01.0
Std. dev. time between licks in bursts0.81.02.0-1.4-1.1-1.11.1-1.0-0.7-0.7-0.70.10.8-0.5-1.2-1.21.2-1.2
Total sessions with >9 infusions0.30.31.2-0.3-0.3-0.10.1-0.10.20.20.20.60.8-0.9-1.1-0.60.6-0.6
Short access day 1 total inactive lever presses0.00.00.1-0.1-0.2-0.20.2-0.2-0.2-0.2-0.2-0.2-0.20.10.00.3-0.10.1
Short access day 10 total inactive lever presses0.30.30.80.0-0.1-0.20.2-0.3-0.4-0.4-0.4-0.8-0.90.90.80.8-0.60.6
Short access day 1 total infusions0.40.41.3-0.6-0.5-0.30.4-0.30.00.00.00.50.8-0.8-1.1-0.80.8-0.8
Short access day 10 total infusions0.00.00.10.0-0.1-0.10.1-0.10.10.10.1-0.1-0.2-0.0-0.10.3-0.30.3
Short access total infusions0.10.10.6-0.1-0.2-0.00.1-0.00.20.20.20.40.5-0.7-0.8-0.20.2-0.2
Short access day 1 locomotion0.60.71.9-1.4-1.0-1.11.0-0.9-0.7-0.7-0.7-0.40.20.0-0.5-0.91.0-1.0
Short access day 10 total locomotion3.03.35.4-2.0-2.1-2.32.2-2.3-2.3-2.3-2.3-2.2-1.41.70.50.3-0.30.3
Short access total locomotion0.60.61.3-1.1-1.0-1.11.1-1.0-0.8-0.8-0.8-0.6-0.10.3-0.3-0.40.4-0.4
One hour access (0.3 mA shock)0.10.10.30.40.60.4-0.50.50.50.50.50.2-0.1-0.10.30.20.0-0.0
Compulsive drug intake0.70.71.10.70.91.0-1.01.00.90.90.91.10.8-0.8-0.2-0.40.5-0.5
One hour access (shock baseline)0.20.20.7-0.00.0-0.30.2-0.2-0.2-0.2-0.2-0.7-0.80.70.70.8-0.50.5
Social response proportion0.40.50.9-0.9-0.9-0.80.8-0.8-0.8-0.8-0.8-0.20.3-0.1-0.6-0.60.6-0.6
Social responses4.76.112.0-3.4-3.5-3.23.2-3.2-3.0-3.0-3.0-1.50.30.5-1.5-1.41.3-1.3
Social time0.40.61.21.01.11.0-1.01.00.90.90.90.4-0.1-0.10.50.4-0.30.3
Soleus weight5.616.328.45.05.35.3-5.35.35.25.25.23.71.4-2.40.70.8-0.80.8
Bone: stiffness2.23.56.01.82.12.2-2.22.32.52.52.52.21.4-1.8-0.5-0.50.5-0.5
Tibialis anterior weight0.62.14.01.71.92.0-1.91.91.81.81.81.40.7-0.90.10.2-0.20.2
Time to tail flick, vehicle, before self-admin1.01.02.7-1.1-1.0-0.70.8-0.8-0.5-0.5-0.50.51.2-0.9-1.7-1.31.3-1.3
Time to tail flick, vehicle, after self-admin0.60.71.80.4-0.2-0.10.2-0.3-0.6-0.6-0.6-0.8-1.11.00.91.0-1.41.4
Time to tail flick, test, before self-admin0.80.82.6-0.7-0.6-0.30.4-0.3-0.1-0.1-0.10.81.2-1.2-1.6-1.31.1-1.1
Time to tail flick, test, after self-admin0.30.31.1-0.6-0.6-0.40.5-0.3-0.2-0.2-0.20.30.7-0.7-1.1-1.00.6-0.6
Delta time to tail flick, vehicle, before/after SA1.41.43.41.30.90.8-0.80.60.30.30.3-0.7-1.51.11.81.6-1.91.9
Delta time to tail flick, test, before/after SA0.50.41.0-0.0-0.1-0.30.3-0.3-0.5-0.5-0.5-0.9-1.01.01.00.7-0.80.8
Tibia length0.61.72.9-1.5-1.6-1.71.6-1.7-1.7-1.7-1.7-1.5-0.81.20.20.1-0.10.1
Ambulatory time before self-admin0.20.20.20.40.50.4-0.50.50.50.50.50.50.4-0.4-0.2-0.30.1-0.1
Ambulatory time after self-admin0.30.40.7-0.8-0.8-0.80.8-0.8-0.7-0.7-0.7-0.40.00.2-0.3-0.50.2-0.2
Bone: tissue strength1.31.32.51.11.31.3-1.31.41.61.61.61.20.7-1.0-0.2-0.20.2-0.2
Total heroin consumption1.21.42.8-1.5-1.6-1.61.6-1.7-1.4-1.4-1.4-0.9-0.30.5-0.5-0.20.1-0.1
Bone: trabecular number1.21.93.6-1.7-1.3-1.01.1-0.9-0.7-0.7-0.70.51.6-1.1-1.9-1.91.9-1.9
Bone: trabecular spacing2.32.96.81.71.10.7-0.80.60.10.10.1-1.3-2.41.92.62.6-2.62.6
Bone: trabecular thickness4.45.312.5-1.5-0.6-0.10.20.10.70.70.72.43.5-3.0-3.5-3.53.5-3.5
Bone: trabecular tissue density1.62.34.42.12.01.7-1.81.71.71.71.70.4-0.80.21.41.4-1.41.4
Water consumed over 24 hours0.81.01.90.30.60.8-0.70.81.01.01.01.41.3-1.4-1.1-1.11.1-1.1
Number of responses in last shaping day0.10.10.3-0.5-0.5-0.50.5-0.4-0.3-0.3-0.3-0.2-0.00.1-0.2-0.00.2-0.2