Hub : Genes

Aspg

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Aspg	0.03	0.03	1.1e-04	0.04	0.04	0.02	0.04	3.1e-05	8.5e-05	1.3e-03	9.9e-05
2	Brain	gene expression	Aspg	0.04	0.04	4.3e-03	0.02	0.01	0	0.01	1.2e-02	5.9e-02	1.2e-01	3.8e-02
3	Eye	gene expression	Aspg	0.91	0.06	2.9e-08	0.25	0.33	0.33	0.33	8.8e-05	5.5e-06	4.4e-06	5.1e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.1	0.2	0.3	0.6	0.4	-0.5
Area under the delay curve	0.2	0.3	0.4	0.6	0.5	-0.2
BMI with tail	3.6	12.4	13.5	3.3	3.6	-3.7
BMI without tail	1.5	8.1	9.6	2.4	3.0	-3.1
Body weight	0.2	0.7	1.7	-1.3	-0.5	-0.0
Weight adjusted by age	0.1	0.2	0.5	-0.7	-0.2	-0.1
Bone surface	0.2	0.3	0.3	0.6	0.5	-0.5
Bone volume	0.2	0.3	0.4	0.5	0.6	-0.6
Breakpoint value in progressive ratio session	0.0	0.0	0.1	0.2	0.1	0.3
Number of licking bursts	0.0	0.1	0.1	0.1	-0.3	0.2
Context. condit. distance diff. score	1.9	2.3	3.2	-1.8	-1.4	1.3
Locomotion velocity, session 1	0.1	0.1	0.1	-0.3	-0.4	0.3
Locomotion distance, session 1	0.5	0.7	1.2	1.1	0.8	-0.5
Locomotion velocity, session 2	0.0	0.0	0.0	-0.2	-0.2	0.1
Locomotion distance, session 2	0.3	0.5	0.6	0.7	0.8	-0.6
Locomotion velocity, session 3	0.1	0.1	0.2	0.4	0.3	-0.2
Locomotion distance, session 3	0.0	0.0	0.1	0.1	-0.2	0.3
Stereotopy head waving bouts, day 3	0.2	0.2	0.3	-0.4	-0.3	0.6
Stereotopy head waving duration, day 3	0.3	0.4	0.5	-0.7	-0.4	0.7
Locomotion velocity, session 7	0.2	0.2	0.4	0.6	0.3	-0.2
Locomotion distance, session 7	0.5	0.7	0.8	0.9	0.8	-0.8
Stereotopy head waving bouts, day 7	0.6	0.7	0.8	-0.9	-0.9	0.7
Stereotopy head waving duration, day 7	0.3	0.4	0.4	-0.7	-0.7	0.5
Locomotion velocity, session 8	0.3	0.3	0.7	-0.8	-0.5	0.4
Locomotion distance, session 8	0.1	0.1	0.1	-0.2	0.4	-0.4
Degree of sensitization distance	0.1	0.1	0.1	0.3	0.1	-0.2
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.3	-0.6	0.4
Conditioned locomotion	1.4	1.6	2.0	-1.4	-1.2	1.2
Cocaine response after cond. corrected	0.3	0.5	0.6	0.6	0.8	-0.7
Cocaine response after cond. not corrected	1.3	2.0	2.1	1.4	1.5	-1.3
Cocaine response before conditioning	2.5	3.0	3.4	1.8	1.7	-1.7
Saline control response	0.2	0.2	0.5	0.2	0.4	-0.7
Bone: connectivity density	0.0	0.0	0.0	-0.0	-0.1	-0.1
Bone: cortical apparent density	7.5	11.8	12.6	-3.4	-3.5	3.4
Bone: cortical area	0.4	0.7	1.0	-1.0	-0.7	0.8
Bone: cortical porosity	0.1	0.1	0.3	-0.5	-0.1	0.0
Bone: cortical porosity	0.2	0.2	0.3	0.2	0.5	-0.6
Bone: cortical thickness	0.6	0.9	1.0	-1.0	-0.9	1.0
Bone: cortical thickness	0.8	1.0	1.5	-1.2	-0.9	0.8
Bone: cortical tissue density	7.3	11.6	12.3	-3.3	-3.5	3.3
Condit. Reinf. active minus inactive responses	0.5	0.6	0.8	0.7	0.9	-0.6
Condit. Reinf. active-inactive response ratio	2.5	2.7	3.1	1.6	1.8	-1.6
Condit. Reinf. active responses	0.1	0.1	0.2	0.2	0.5	-0.3
Condit. Reinf. inactive responses	1.9	2.5	2.7	-1.5	-1.6	1.6
Incentive salience index mean	0.5	0.6	0.7	0.8	0.9	-0.6
Condit. Reinf. lever presses	0.1	0.2	0.2	0.5	0.4	-0.3
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	-0.7	-0.6	0.4
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.7	-0.8	-0.6	0.5
Condit. Reinf. active responses	0.0	0.0	0.0	0.1	0.1	-0.2
Condit. Reinf. inactive responses	0.6	0.8	0.9	0.9	0.9	-0.9
Condit. Reinf. lever presses	1.6	2.3	2.6	1.3	1.6	-1.6
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	-0.0	0.1	-0.3
Conditioned reinforcement - actives	0.2	0.9	1.0	-0.9	-1.0	1.0
Conditioned reinforcement - inactives	0.1	0.2	0.3	-0.3	-0.5	0.4
Conditioned locomotion	0.3	0.5	0.7	0.5	0.8	-0.8
Patch foraging indifference point 0 sec	2.1	5.8	7.5	-2.7	-2.3	2.2
Patch foraging indifference point AUC	1.1	2.6	3.4	-1.2	-1.8	1.8
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	-0.4	-0.2	0.6
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.4	0.4	-0.0
Delay disc. indifference point, 2s delay	0.3	0.4	0.6	0.8	0.7	-0.1
Delay disc. indifference point, 24s delay	0.2	0.3	0.5	0.7	0.5	-0.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.4	-0.2	0.5
Delay disc. indifference point, 8s delay	0.2	0.4	0.5	0.7	0.6	-0.5
Indifference point function ln k	0.3	0.8	1.7	-1.3	-0.7	0.3
Indifference point function log k	0.3	0.8	1.7	-1.3	-0.7	0.3
Patch foraging total patch changes 0 sec	2.2	6.5	8.3	-2.9	-2.5	2.3
Patch foraging total patch changes 12 sec	4.0	5.4	5.7	-2.3	-2.4	2.3
Patch foraging total patch changes 18 sec	1.0	2.4	3.5	-1.1	-1.5	1.9
Patch foraging total patch changes 24 sec	0.1	0.3	0.3	-0.5	-0.5	0.5
Patch foraging total patch changes 6 sec	2.2	3.8	4.5	-2.1	-1.9	1.8
Patch foraging time to switch 0 sec	4.3	16.5	17.9	4.1	4.2	-3.9
Patch foraging water rate 0 sec	8.0	30.2	31.7	-5.6	-5.6	5.3
Patch foraging water rate 12 sec	3.8	15.5	18.9	-4.4	-3.9	3.5
Patch foraging water rate 18 sec	3.0	6.8	8.2	-2.6	-2.9	2.4
Patch foraging water rate 24 sec	3.9	5.5	7.2	-2.7	-2.4	1.9
Patch foraging water rate 6 sec	4.8	7.1	8.4	-2.9	-2.6	2.4
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.4	-0.6	-0.2	0.6
Distance traveled before self-admin	0.2	0.4	0.5	0.7	0.3	-0.7
Distance traveled after self-admin	0.1	0.2	0.3	-0.4	-0.5	0.1
Extensor digitorum longus weight	5.6	22.2	27.1	-5.2	-4.7	4.2
Bone: elastic displacement	0.3	0.4	0.5	-0.5	-0.7	0.7
Bone: elastic work	0.1	0.1	0.1	-0.2	-0.3	0.4
Bone: endosteal estimation	0.4	0.9	1.2	0.7	1.1	-1.1
Bone: endosteal perimeter	0.1	0.2	0.4	0.0	0.6	-0.4
Epididymis fat weight	1.8	9.0	9.6	3.1	3.0	-2.9
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.2	0.2	-0.4
Delta time in open arm before/after self-admin	0.6	0.7	1.0	-0.4	-1.0	1.0
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	0.0	0.1
Delay discount exponential model param	0.2	0.2	0.4	-0.6	-0.5	0.3
Extinction: sum of active levers before priming	0.2	0.4	0.6	0.7	0.6	-0.4
Active lever presses in extinction session 6	1.4	1.4	2.1	-1.4	-1.1	0.9
Bone: final force	0.1	0.2	0.3	-0.6	-0.2	0.3
Bone: final moment	0.1	0.1	0.3	-0.6	-0.2	0.3
Food consumed during 24 hour testing period	0.0	0.1	0.2	-0.4	-0.2	0.1
Glucose	0.9	1.5	1.8	-1.0	-1.2	1.3
Heart weight	0.7	1.1	1.7	-0.9	-1.3	1.0
Delay discount hyperbolic model param	0.1	0.2	0.3	-0.6	-0.5	0.2
Intermittent access intake day 1-15 change	0.5	2.8	3.2	1.7	1.8	-1.5
Intermittent access intake escalation	0.5	2.6	2.9	1.7	1.7	-1.4
Intermittent access intake escalation 2	0.5	0.8	1.1	1.1	0.9	-0.7
Intermitt. access day 1 inactive lever presses	0.0	0.5	0.7	-0.6	-0.8	0.6
Intermitt. access day 15 inactive lever presses	0.3	1.8	2.6	-1.2	-1.6	1.1
Intermitt. access escalation Index	0.1	0.4	0.8	-0.9	-0.5	0.5
Intermittent access day 1 total infusions	0.1	0.4	0.4	0.7	0.7	-0.6
Intermittent access day 15 total infusions	0.7	1.7	2.0	1.4	1.4	-1.1
Intermittent access terminal intake (last 3 days)	1.2	2.0	2.4	1.6	1.4	-1.3
Intermittent access total infusions	0.7	0.8	0.9	0.9	0.9	-0.8
Intermittent access day 1 locomotion	1.2	2.3	2.6	1.4	1.6	-1.5
Intermittent access day 15 total locomotion	0.1	0.3	0.5	0.6	0.7	-0.3
Intermittent access total locomotion	0.8	1.0	1.3	1.1	1.1	-0.8
Intermittent access standard deviation	0.6	2.9	3.3	1.6	1.7	-1.8
Left kidney weight	0.5	3.7	6.1	-2.5	-1.7	1.4
Right kidney weight	0.5	3.3	5.3	-2.3	-1.7	1.3
Cocaine induced anxiety	1.2	3.2	3.5	-1.7	-1.9	1.8
Post-drug Anxiety	4.3	4.9	5.4	-2.0	-2.3	2.3
Baseline Anxiety	0.0	0.1	0.2	0.4	0.1	-0.0
Tail length	2.5	13.6	17.4	-4.2	-3.6	3.2
Length with tail	5.6	24.7	29.9	-5.5	-5.0	4.4
Length without tail	1.8	9.3	10.9	-3.3	-3.2	2.6
Times rat made contact with spout	0.4	0.5	0.8	-0.6	-0.6	0.9
Lifetime Intake	0.3	0.4	0.5	0.6	0.7	-0.6
Liver weight, left	2.2	3.8	4.8	-2.2	-1.9	1.7
Liver weight, right	0.4	0.8	1.3	0.6	0.7	-1.1
Locomotor activity	0.1	0.2	0.2	-0.5	-0.2	0.5
Locomotor testing distance	0.1	0.3	0.5	-0.6	-0.2	0.7
Locomotor testing rearing	0.6	2.4	3.0	1.7	1.6	-1.2
Locomotion in novel chamber	2.8	3.7	5.6	-2.4	-1.8	1.5
Locomotion in novel chamber post-restriction	0.0	0.1	0.2	0.3	0.0	-0.4
Fecal boli incidents, locomotor time 1	1.1	2.9	3.6	1.9	1.7	-1.5
Change in fecal boli incidents, locomotor task	1.0	1.0	3.0	-1.7	-0.4	-0.0
Time >=10cm from walls, locomotor time 1	0.2	0.3	0.5	0.0	0.6	-0.7
Bouts of movement, locomotor time 1	1.6	2.0	3.5	1.9	1.1	-1.2
Total resting periods, locomotor time 1	1.7	2.0	3.2	1.8	1.1	-1.2
Rest time, locomotor task time 1	0.1	0.2	0.3	0.2	-0.5	0.6
Distance moved, locomotor task time 1	0.1	0.2	0.4	-0.2	0.5	-0.7
Vertical activity count, locomotor time 1	0.1	0.7	0.8	-0.8	-0.9	0.8
Time >=10cm from walls, locomotor time 2	0.2	0.4	0.6	-0.4	-0.8	0.8
Bouts of movement, locomotor time 2	0.5	1.5	1.7	-1.2	-1.3	1.2
Total resting periods, locomotor time 2	0.3	1.2	1.4	-1.0	-1.2	1.1
Rest time, locomotor task time 2	0.2	0.3	0.3	-0.5	-0.5	0.6
Distance moved, locomotor task time 2	0.1	0.2	0.3	0.4	0.4	-0.5
Vertical activity count, locomotor time 2	0.2	0.5	1.0	-0.2	-1.0	0.7
Light reinforcement 1	0.0	0.0	0.1	-0.4	0.1	-0.0
Light reinforcement 2	0.8	1.8	2.2	1.3	1.5	-1.2
Bone: marrow area	0.3	0.8	1.0	0.6	1.0	-1.0
Bone: maximum diameter	0.0	0.0	0.0	-0.1	0.2	0.0
Bone: maximum force	0.0	0.0	0.1	-0.4	0.0	0.1
Bone: maximum moment	0.0	0.0	0.1	-0.3	0.2	-0.0
Mean time between licks in bursts	0.2	0.9	1.3	0.4	1.1	-1.2
Mean num. licks in bursts	0.0	0.1	0.2	-0.4	-0.0	0.2
Cd content in liver	0.1	0.1	0.1	-0.2	0.0	-0.4
Co content in liver	1.0	1.1	1.2	-1.1	-1.1	1.1
Cu content in liver	0.5	0.6	0.7	0.8	0.8	-0.6
Fe content in liver	0.2	0.3	0.5	0.4	0.7	-0.5
K content in liver	0.7	0.7	1.0	-1.0	-0.7	0.8
Mg content in liver	0.6	0.7	1.1	-1.1	-0.6	0.7
Mn content in liver	0.2	0.2	0.3	-0.0	0.5	-0.6
Na content in liver	0.0	0.0	0.0	0.1	0.1	0.1
Rb content in liver	0.8	0.9	1.2	-1.1	-0.8	0.9
Se content in liver	0.2	0.2	0.3	-0.0	0.5	-0.6
Sr content in liver	0.1	0.1	0.2	-0.4	-0.3	0.2
Zn content in liver	1.4	1.6	1.9	-1.4	-1.3	1.2
Bone: minimum diameter	0.4	0.7	1.4	-1.2	-0.6	0.6
Time in familiar zone, hab. session 1	0.2	0.3	0.4	0.5	0.4	-0.6
Time in novel zone, hab. session 1	0.1	0.2	0.2	0.5	0.5	-0.2
Total zone transitions, hab. session 1	0.7	1.0	1.3	0.6	1.1	-1.1
Total locomotion distance, hab. session 1	0.1	0.1	0.4	-0.6	-0.0	-0.2
Locomotion velocity, hab. session 1	0.5	0.7	1.4	-1.2	-0.6	0.4
Time in familiar zone, hab. session 2	0.3	0.4	0.7	0.3	0.5	-0.8
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.3	0.4	-0.1
Total zone transitions, hab. session 2	0.7	0.9	1.2	0.9	1.1	-0.9
Total locomotion distance, hab. session 2	0.4	0.5	0.6	-0.8	-0.6	0.7
Locomotion velocity, hab. session 2	0.6	0.8	0.9	-1.0	-0.8	0.9
Novel to familiar place preference ratio	0.5	0.7	1.3	1.1	0.8	-0.4
Novelty place preference	0.3	0.4	0.9	0.9	0.6	-0.3
Time in novel zone, NPP test	0.3	0.4	0.8	0.9	0.6	-0.3
Total zone transitions, NPP test	0.2	0.3	0.4	0.3	0.6	-0.6
Total locomotion distance, NPP test	0.0	0.0	0.1	-0.2	0.1	-0.0
Locomotion velocity, NPP test	0.0	0.0	0.1	-0.3	0.0	0.1
Intraocular pressure	0.1	0.1	0.3	0.5	0.1	-0.2
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.1	0.2	-0.2
Delta ambulatory time before/after self-admin	0.3	0.5	0.8	-0.9	-0.6	0.6
Parametrial fat weight	0.4	0.9	1.2	0.7	1.0	-1.1
Pavlov. Cond. lever latency	0.6	0.7	0.9	-1.0	-0.9	0.7
Pavlov. Cond. magazine entry latency	0.7	0.9	1.1	1.0	0.9	-0.9
Pavlov. Cond. change in total contacts	0.2	0.3	0.3	0.6	0.5	-0.4
Pavlov. Cond. index score	1.1	1.3	1.7	1.3	1.1	-1.0
Pavlov. Cond. latency score	0.7	0.9	1.2	1.1	1.0	-0.8
Pavlov. Cond. lever contacts	1.0	1.3	1.7	1.3	1.1	-0.9
Pavlov. Cond. magazine entry number	1.1	1.4	1.4	-1.2	-1.2	1.2
Pavlov. Cond. intertrial magazine entries	5.7	6.8	7.8	-2.8	-2.6	2.4
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.1	1.4	1.2	1.0	-0.9
Pavlov. Cond. response bias	1.7	2.1	2.1	1.5	1.5	-1.4
Pavlov. Cond. lever latency	2.2	3.1	3.7	-1.4	-1.9	1.9
Pavlov. Cond. magazine entry latency	4.1	5.8	6.7	2.2	2.4	-2.6
Pavlov. Cond. change in total contacts	2.2	5.4	5.5	2.3	2.3	-2.3
Pavlov. Cond. index score	4.2	6.6	7.7	2.3	2.7	-2.8
Pavlov. Cond. latency score	4.1	6.5	7.3	2.3	2.6	-2.7
Pavlov. Cond. lever contacts	2.9	4.2	4.9	1.7	2.2	-2.2
Pavlov. Cond. magazine entry number	3.7	4.8	5.7	-2.0	-2.2	2.4
Pavlov. Cond. intertrial magazine entries	3.4	7.5	7.7	-2.7	-2.8	2.8
Pavlov. Cond. lever-magazine prob. diff.	4.7	7.2	8.1	2.4	2.8	-2.9
Pavlov. Cond. response bias	3.8	5.3	6.4	1.9	2.4	-2.5
Time in closed arm before self-admin	1.6	2.8	4.2	2.1	1.5	-1.3
Time in closed arm after self-admin	0.9	1.0	1.0	0.9	1.0	-1.0
Time in open arm before self-admin	2.5	3.0	4.9	-2.2	-1.7	1.2
Time in open arm after self-admin	2.3	2.6	3.2	-1.6	-1.8	1.4
Bone: periosteal estimation	0.0	0.1	0.1	-0.3	0.2	-0.1
Bone: periosteal perimeter	0.0	0.1	0.1	-0.2	0.4	-0.1
Bone: post-yield work	0.8	1.4	1.8	-1.3	-1.2	1.0
Progressive ratio test 1 active lever presses	0.1	0.2	0.3	0.6	0.3	-0.4
Progressive ratio test 1 breakpoint	0.2	0.3	0.5	0.7	0.4	-0.5
Progressive ratio test 1 inactive lever presses	0.7	1.9	2.3	-1.4	-1.5	1.2
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	-0.2	-0.3	0.4
Progressive ratio test 2 breakpoint	0.1	0.1	0.1	-0.2	-0.3	0.4
Progressive ratio test 2 inactive lever presses	0.3	1.1	1.6	-0.7	-1.3	1.1
Incentive Sensitization - Responses	0.0	0.1	0.2	-0.3	-0.3	0.4
Incentive Sensitization - Breakpoint	0.1	0.2	0.2	-0.4	-0.4	0.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.2	-0.3	-0.4	0.5
Progressive ratio	0.1	0.4	0.9	-0.9	-0.4	0.4
Food seeking constrained by brief footshock	1.3	1.6	2.8	-0.5	-1.3	1.7
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	0.6	-0.2	0.4
Retroperitoneal fat weight	0.1	0.4	0.4	0.6	0.6	-0.7
Reaction time number correct	1.4	5.1	5.6	-2.2	-2.4	2.1
Reaction time mean minus median	0.0	0.3	0.4	0.6	0.4	-0.5
Reaction time mean minus median AUC	0.0	0.3	0.3	0.6	0.4	-0.6
Reaction time num false alarms	0.8	1.4	1.8	-1.4	-0.9	1.2
Reaction time num false alarms AUC	0.9	2.0	2.6	-1.6	-1.2	1.4
Reaction time trials correct on left	1.4	5.1	5.6	-2.2	-2.4	2.1
Reaction time trials on left	1.5	5.0	5.6	-2.2	-2.4	2.1
Reaction time mean	0.6	1.4	1.5	1.2	1.1	-1.1
Reaction time mean AUC	0.4	0.9	1.0	1.0	0.9	-0.9
Median of all reaction times	0.5	0.7	0.8	0.8	0.9	-0.9
Reaction time omissions	0.2	0.3	0.6	-0.4	-0.8	0.6
Reaction time false alarm rate	0.1	0.1	0.2	-0.5	-0.0	0.3
Reaction time premature initiation rate	0.8	1.2	1.3	-1.1	-1.0	1.1
Reaction time premature initiations	1.3	3.9	4.1	-2.0	-2.0	1.9
Std. dev. reaction times	0.2	0.7	0.8	0.9	0.7	-0.8
Reaction time trials completed	1.5	5.0	5.6	-2.2	-2.4	2.1
Reaction time trials AUC	1.6	5.5	6.2	-2.3	-2.5	2.2
Run reversals in cocaine runway, females	0.6	0.6	0.9	1.0	0.7	-0.6
Run reversals in cocaine runway, males	0.9	1.0	1.5	-0.5	-1.2	1.2
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.3	0.5	-0.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.5	0.4	0.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.0	0.4	-0.3
Std. dev. time between licks in bursts	0.5	1.0	1.5	0.3	1.2	-1.2
Total sessions with >9 infusions	0.2	0.2	0.3	0.3	0.5	-0.5
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.2	-0.1	0.0
Short access day 10 total inactive lever presses	0.0	0.1	0.1	0.0	-0.2	-0.4
Short access day 1 total infusions	0.2	0.3	0.4	-0.6	-0.4	0.6
Short access day 10 total infusions	0.4	0.7	0.7	0.8	0.8	-0.8
Short access total infusions	0.2	0.2	0.3	0.3	0.6	-0.5
Short access day 1 locomotion	0.2	0.3	0.4	0.4	0.6	-0.6
Short access day 10 total locomotion	0.8	3.3	3.7	1.9	1.9	-1.7
Short access total locomotion	0.2	0.3	0.4	0.7	0.6	-0.4
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.1	-0.3	0.2
Compulsive drug intake	0.0	0.0	0.1	-0.2	-0.2	0.0
One hour access (shock baseline)	0.0	0.0	0.0	-0.2	0.0	0.0
Social response proportion	0.4	0.6	0.9	-1.0	-0.7	0.5
Social responses	0.0	0.0	0.0	-0.0	0.2	-0.2
Social time	0.7	1.1	1.9	-1.4	-1.0	0.7
Soleus weight	0.0	0.1	0.2	-0.3	0.2	-0.5
Bone: stiffness	0.7	1.2	1.8	-1.3	-0.9	1.0
Tibialis anterior weight	0.2	0.8	1.0	-1.0	-0.9	0.7
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.4	-0.6	-0.5	0.5
Time to tail flick, vehicle, after self-admin	0.2	0.4	0.8	0.3	0.6	-0.9
Time to tail flick, test, before self-admin	0.1	0.1	0.1	0.4	-0.2	0.2
Time to tail flick, test, after self-admin	0.9	1.0	1.2	-1.1	-1.1	0.8
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.1	0.1	-0.1
Delta time to tail flick, test, before/after SA	0.6	0.8	1.7	-1.3	-0.7	0.4
Tibia length	0.3	0.9	1.5	-0.6	-0.9	1.2
Ambulatory time before self-admin	0.2	0.6	1.1	1.0	0.5	-0.8
Ambulatory time after self-admin	0.1	0.1	0.2	0.4	0.1	-0.4
Bone: tissue strength	0.2	0.2	0.4	0.1	-0.3	0.6
Total heroin consumption	2.4	2.8	3.6	-1.4	-1.7	1.9
Bone: trabecular number	0.0	0.0	0.0	0.0	-0.1	-0.1
Bone: trabecular spacing	0.0	0.0	0.0	-0.0	0.1	-0.2
Bone: trabecular thickness	0.0	0.1	0.1	0.3	0.2	-0.2
Bone: trabecular tissue density	0.1	0.2	0.5	-0.1	-0.4	0.7
Water consumed over 24 hours	1.8	3.5	3.8	-1.9	-1.7	2.0
Number of responses in last shaping day	0.1	0.2	0.3	0.1	0.5	-0.5