Asap3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Asap3	0.1	0.05	0.0e+00	0.15	0.15	0.15	0.15	1.9e-17	8.2e-17	7.3e-17	3.5e-17
2	RMTg	gene expression	Asap3	0.33	0.14	4.0e-08	0.24	0.25	0.24	0.24	4.4e-07	2.0e-07	4.8e-07	4.6e-07
3	Brain	gene expression	Asap3	0.33	0.1	0.0e+00	0.42	0.42	0.41	0.43	3.9e-42	1.4e-41	8.2e-41	6.7e-43
4	pVTA	gene expression	Asap3	0.36	0.12	5.6e-17	0.28	0.33	0.33	0.35	1.9e-12	6.6e-15	4.6e-15	9.6e-16
5	LHb	gene expression	Asap3	0.41	0.14	2.8e-10	0.36	0.34	0.35	0.36	2.0e-09	5.4e-09	3.6e-09	1.8e-09
6	PL	gene expression	Asap3	0.08	0.05	2.8e-08	0.06	0.07	0.06	0.07	2.1e-07	2.3e-08	8.9e-07	5.6e-08
7	OFC	gene expression	Asap3	0.18	0.14	1.5e-03	0.18	0.17	0.17	0.16	4.0e-05	7.7e-05	6.6e-05	1.2e-04
8	Adipose	gene expression	Asap3	0.25	0.1	0.0e+00	0.24	0.23	0.23	0.23	1.4e-26	1.4e-25	5.5e-25	2.5e-25
9	BLA	gene expression	Asap3	0.11	0.09	2.9e-03	0.03	0.02	0.05	0.02	7.8e-03	1.9e-02	1.6e-03	3.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	1.1	1.9	2.6	1.6	-1.4	-1.6	-1.1	-1.3	-1.3	1.5	1.5	1.0
Area under the delay curve	0.6	0.6	1.2	1.1	-0.8	-0.9	-1.0	-0.9	-0.6	0.4	0.7	0.0
BMI with tail	2.4	7.8	10.6	2.9	-3.0	-2.9	-2.9	-3.3	-2.8	2.6	2.9	1.6
BMI without tail	2.0	4.1	5.7	2.2	-2.2	-2.1	-2.4	-2.3	-1.8	1.9	2.1	0.6
Body weight	5.2	21.8	28.6	5.4	-4.7	-5.0	-4.5	-5.1	-4.6	4.4	4.7	3.5
Weight adjusted by age	0.1	0.1	0.2	-0.3	0.2	0.4	0.1	0.2	0.2	-0.4	-0.1	-0.0
Bone surface	1.4	2.5	3.6	1.9	-1.6	-1.8	-1.4	-1.5	-1.4	1.7	1.5	1.1
Bone volume	1.1	1.9	2.7	1.6	-1.4	-1.6	-1.2	-1.4	-1.2	1.5	1.4	0.7
Breakpoint value in progressive ratio session	0.7	0.7	2.7	-0.4	0.8	0.5	1.2	0.8	0.2	-0.5	-0.6	1.7
Number of licking bursts	0.2	0.3	0.6	-0.5	0.5	0.5	0.8	0.5	0.1	-0.4	-0.4	0.5
Context. condit. distance diff. score	1.3	1.6	2.0	1.2	-1.3	-1.4	-1.1	-1.2	-1.4	1.2	1.2	1.3
Locomotion velocity, session 1	0.7	0.7	1.1	0.9	-1.0	-0.8	-1.0	-0.7	-0.8	0.9	1.0	-0.2
Locomotion distance, session 1	0.1	0.1	0.7	0.2	-0.1	-0.0	-0.5	-0.1	0.1	0.2	0.0	-0.8
Locomotion velocity, session 2	2.7	3.1	6.5	-1.8	1.7	1.7	1.1	1.6	1.8	-1.7	-1.6	-2.5
Locomotion distance, session 2	0.5	0.8	1.3	0.7	-1.0	-0.8	-1.1	-0.8	-0.8	1.1	1.0	-0.1
Locomotion velocity, session 3	0.5	0.6	1.2	-0.7	0.9	0.7	1.1	1.0	0.5	-0.4	-1.0	-0.1
Locomotion distance, session 3	1.1	1.2	1.9	1.0	-1.1	-1.1	-1.2	-0.9	-1.3	1.4	0.9	1.1
Stereotopy head waving bouts, day 3	1.0	1.2	1.8	-0.9	1.1	1.1	1.1	1.2	1.3	-0.9	-1.0	-1.4
Stereotopy head waving duration, day 3	1.6	1.9	2.5	-1.2	1.4	1.4	1.4	1.5	1.5	-1.3	-1.2	-1.6
Locomotion velocity, session 7	1.2	1.4	1.9	0.9	-1.3	-1.2	-1.2	-1.1	-1.4	1.4	1.1	0.8
Locomotion distance, session 7	0.1	0.2	0.4	0.1	-0.5	-0.5	-0.3	-0.5	-0.6	0.6	0.4	0.3
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.4	-0.1	-0.3	-0.4	-0.2	-0.1	0.0	-0.0	-0.1
Stereotopy head waving duration, day 7	0.2	0.2	0.6	0.8	-0.4	-0.6	-0.6	-0.4	-0.3	0.3	0.3	-0.1
Locomotion velocity, session 8	0.3	0.4	0.6	0.8	-0.6	-0.7	-0.8	-0.5	-0.5	0.5	0.5	-0.2
Locomotion distance, session 8	2.0	3.0	3.6	1.7	-1.8	-1.9	-1.7	-1.8	-1.9	1.8	1.6	1.1
Degree of sensitization distance	1.6	1.6	2.2	-1.3	1.2	1.2	1.3	1.0	1.3	-1.5	-1.0	-1.5
Degree of sensitization stereotypy	0.9	1.0	1.9	1.3	-1.0	-1.1	-1.4	-1.1	-0.9	0.7	0.7	0.7
Conditioned locomotion	2.2	2.6	4.1	-1.5	1.6	1.5	1.1	1.6	2.0	-1.4	-1.9	-1.6
Cocaine response after cond. corrected	4.6	5.2	8.0	-2.4	2.2	2.2	1.7	2.3	2.3	-2.2	-2.1	-2.8
Cocaine response after cond. not corrected	4.9	5.4	6.5	-2.6	2.4	2.3	1.9	2.4	2.4	-2.2	-2.3	-2.5
Cocaine response before conditioning	0.6	0.7	1.7	0.8	-0.8	-0.8	-0.6	-0.8	-0.9	0.9	0.7	1.3
Saline control response	0.7	0.9	2.5	-1.0	0.9	0.9	1.6	1.3	0.5	-0.5	-0.7	0.7
Bone: connectivity density	0.5	0.7	1.0	0.9	-0.8	-1.0	-0.7	-0.8	-0.7	0.9	0.7	1.0
Bone: cortical apparent density	0.2	0.2	0.6	-0.4	0.6	0.3	0.8	0.5	0.3	-0.3	-0.3	0.4
Bone: cortical area	3.1	4.6	5.8	2.4	-2.2	-2.3	-1.6	-2.1	-2.2	2.1	2.1	2.3
Bone: cortical porosity	1.8	1.9	2.7	-1.5	1.4	1.5	1.0	1.3	1.4	-1.5	-1.6	-1.1
Bone: cortical porosity	2.5	2.7	3.6	-1.6	1.7	1.7	1.2	1.5	1.8	-1.8	-1.9	-1.7
Bone: cortical thickness	1.5	2.4	3.7	1.9	-1.4	-1.7	-0.8	-1.4	-1.6	1.4	1.4	1.9
Bone: cortical thickness	0.3	0.3	1.6	0.8	0.1	-0.5	0.5	0.1	-0.3	0.1	-0.0	1.3
Bone: cortical tissue density	0.3	0.4	0.8	-0.6	0.7	0.5	0.9	0.7	0.5	-0.5	-0.5	0.1
Condit. Reinf. active minus inactive responses	0.7	0.8	2.4	-0.4	0.9	0.6	0.5	0.6	0.7	-1.2	-0.9	-1.5
Condit. Reinf. active-inactive response ratio	0.7	0.8	3.6	-0.3	0.7	0.5	0.5	0.5	0.7	-1.0	-0.7	-1.9
Condit. Reinf. active responses	0.4	0.5	1.4	-0.5	0.5	0.6	0.1	0.3	0.5	-0.9	-0.7	-1.2
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.2	-0.2	0.2	-0.4	-0.3	-0.1	0.0	0.1	0.5
Incentive salience index mean	0.5	0.6	1.4	-0.6	0.7	0.7	0.4	0.6	0.6	-1.0	-0.8	-1.2
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.5	0.1	0.3	-0.0	0.1	0.1	-0.2	-0.2	-0.4
Condit. Reinf. active minus inactive responses	1.8	2.2	2.8	1.6	-1.5	-1.6	-1.7	-1.6	-1.3	1.2	1.5	1.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.5	-0.0	0.4	0.2	0.0	0.2	0.5	-0.7	-0.4	-0.3
Condit. Reinf. active responses	5.6	7.8	8.7	2.9	-2.8	-2.9	-2.7	-2.7	-2.7	2.7	2.8	2.7
Condit. Reinf. inactive responses	8.0	9.9	11.8	3.1	-3.2	-3.3	-2.9	-3.0	-3.2	3.4	3.2	2.9
Condit. Reinf. lever presses	1.8	2.4	3.3	1.8	-1.6	-1.7	-1.4	-1.4	-1.5	1.8	1.4	1.3
Condit. Reinf. lever reinforcers received	5.0	7.0	8.0	2.8	-2.7	-2.8	-2.5	-2.6	-2.5	2.6	2.7	2.4
Conditioned reinforcement - actives	1.5	1.5	3.3	1.1	-1.4	-1.0	-1.8	-1.4	-1.1	1.0	1.3	0.5
Conditioned reinforcement - inactives	1.3	1.5	3.0	1.2	-1.3	-1.2	-1.7	-1.3	-1.2	0.8	1.3	0.6
Conditioned locomotion	2.2	2.7	5.1	1.7	-1.7	-1.5	-2.3	-1.9	-1.5	1.0	1.6	1.3
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.3	-0.4	-0.3	-0.2	-0.2	-0.6	0.7	0.4	0.7
Patch foraging indifference point AUC	1.1	1.2	1.9	1.0	-1.2	-1.0	-1.1	-1.2	-1.4	1.1	1.2	0.5
Delay disc. indifference point, 0s delay	1.2	1.3	2.5	1.6	-1.1	-1.4	-0.8	-1.2	-1.1	1.1	1.2	0.6
Delay disc. indifference point, 16s delay	0.3	0.3	0.7	0.8	-0.6	-0.7	-0.7	-0.7	-0.3	0.4	0.5	0.1
Delay disc. indifference point, 2s delay	1.0	1.2	2.1	1.5	-0.9	-1.3	-0.8	-1.1	-1.1	0.9	0.9	1.1
Delay disc. indifference point, 24s delay	0.2	0.2	0.8	-0.1	0.3	0.4	-0.2	0.1	0.5	-0.7	-0.3	-0.9
Delay disc. indifference point, 4s delay	0.6	0.6	1.4	1.2	-0.7	-1.0	-0.7	-0.9	-0.6	0.4	0.8	-0.5
Delay disc. indifference point, 8s delay	0.7	0.7	1.7	1.1	-0.9	-0.9	-1.3	-1.0	-0.5	0.4	0.8	-0.1
Indifference point function ln k	1.6	2.2	4.6	-1.3	1.3	1.3	0.7	1.3	2.1	-1.2	-1.5	-2.2
Indifference point function log k	1.6	2.2	4.6	-1.3	1.3	1.3	0.7	1.3	2.1	-1.2	-1.5	-2.2
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	0.2	-0.3	-0.3	-0.2	-0.1	-0.5	0.6	0.3	0.7
Patch foraging total patch changes 12 sec	0.7	0.9	2.0	0.8	-0.9	-0.8	-0.7	-0.9	-1.4	1.0	0.8	1.2
Patch foraging total patch changes 18 sec	0.4	0.5	1.1	0.6	-0.7	-0.6	-0.4	-0.6	-1.0	1.1	0.6	0.5
Patch foraging total patch changes 24 sec	1.1	1.3	2.3	1.3	-1.0	-1.1	-0.8	-1.0	-1.5	1.2	1.0	1.5
Patch foraging total patch changes 6 sec	0.7	1.0	2.0	0.7	-0.9	-0.7	-0.5	-0.7	-1.4	1.3	1.0	1.4
Patch foraging time to switch 0 sec	0.6	0.9	1.7	-0.9	1.0	0.9	1.3	0.9	0.5	-1.0	-1.2	0.7
Patch foraging water rate 0 sec	0.3	0.4	1.6	-0.4	0.5	0.5	0.3	0.5	0.8	-0.3	-0.5	-1.3
Patch foraging water rate 12 sec	0.1	0.1	0.3	0.4	-0.3	-0.3	-0.4	-0.3	-0.1	0.3	0.4	0.6
Patch foraging water rate 18 sec	1.2	1.7	2.4	1.3	-1.3	-1.4	-1.6	-1.3	-1.0	1.5	1.3	0.8
Patch foraging water rate 24 sec	0.5	0.7	1.2	-0.9	0.8	0.8	0.3	0.8	1.1	-0.6	-0.7	-1.0
Patch foraging water rate 6 sec	0.4	0.6	1.1	-0.6	0.8	0.8	0.4	0.8	1.0	-0.8	-0.8	-0.9
Seeking ratio, delayed vs. immediate footshock	2.1	2.4	3.4	1.6	-1.5	-1.7	-1.0	-1.5	-1.6	1.8	1.5	1.5
Distance traveled before self-admin	4.4	4.6	6.5	2.1	-2.1	-2.2	-1.7	-2.0	-2.2	2.2	2.3	2.5
Distance traveled after self-admin	3.1	3.4	4.3	1.8	-1.9	-1.9	-1.7	-1.8	-1.8	2.1	1.8	1.9
Extensor digitorum longus weight	0.7	2.8	3.4	1.8	-1.7	-1.8	-1.5	-1.8	-1.6	1.7	1.7	1.2
Bone: elastic displacement	0.4	0.5	0.7	-0.6	0.8	0.7	0.5	0.9	0.8	-0.3	-0.8	-0.6
Bone: elastic work	0.0	0.0	0.3	-0.0	0.1	0.0	0.1	0.2	-0.0	0.5	-0.1	0.1
Bone: endosteal estimation	2.2	4.8	7.4	2.4	-2.4	-2.2	-2.7	-2.3	-1.8	2.1	2.2	1.0
Bone: endosteal perimeter	1.8	3.8	5.8	2.0	-2.3	-2.0	-2.4	-2.1	-1.7	2.0	2.0	0.6
Epididymis fat weight	0.6	1.4	2.9	1.3	-1.2	-1.2	-1.7	-1.5	-0.9	0.8	1.1	0.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.1	0.0	0.2	-0.4	-0.1	0.1	-0.5	-0.2	-0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.4	-0.1	0.3	0.2	0.6	0.5	0.1	-0.2	-0.1	-0.1
Diff in mean of infusions in LGA sessions	0.8	0.9	1.2	-1.0	1.0	1.0	0.9	0.9	0.9	-1.1	-1.1	0.1
Delay discount exponential model param	0.5	0.5	1.1	-1.1	0.7	0.8	1.0	0.9	0.5	-0.3	-0.7	0.1
Extinction: sum of active levers before priming	1.3	1.2	2.7	1.4	-0.8	-1.3	-0.4	-0.7	-0.9	1.2	1.1	1.6
Active lever presses in extinction session 6	0.5	0.5	1.5	-0.5	0.8	0.7	0.5	0.5	0.8	-1.2	-0.7	0.3
Bone: final force	2.1	3.4	5.6	1.9	-1.8	-1.8	-1.5	-1.8	-1.8	1.8	1.6	2.4
Bone: final moment	2.7	4.4	5.8	2.1	-2.1	-2.1	-1.9	-2.1	-2.1	2.1	1.9	2.4
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.2	0.3	0.4	0.2	0.4	0.3	-0.1	-0.2	-0.2
Glucose	0.2	0.2	1.2	0.2	-0.2	-0.2	0.3	-0.3	-0.7	0.1	0.4	1.1
Heart weight	0.3	0.4	2.0	0.6	-0.3	-0.6	0.2	-0.4	-0.7	0.4	0.5	1.4
Delay discount hyperbolic model param	0.7	0.7	1.5	-1.2	0.8	1.0	1.1	1.0	0.6	-0.4	-0.8	-0.0
Intermittent access intake day 1-15 change	4.2	4.2	7.6	2.1	-2.2	-2.0	-2.8	-2.3	-1.7	2.0	2.0	0.8
Intermittent access intake escalation	2.8	2.7	6.1	1.6	-1.8	-1.5	-2.5	-1.9	-1.3	1.6	1.6	0.2
Intermittent access intake escalation 2	0.9	0.9	3.1	0.8	-1.0	-0.7	-1.8	-1.1	-0.4	0.8	0.7	-0.7
Intermitt. access day 1 inactive lever presses	4.2	4.5	5.4	2.3	-2.3	-2.3	-2.2	-2.2	-2.2	2.0	2.2	1.1
Intermitt. access day 15 inactive lever presses	1.3	1.5	2.8	1.0	-1.4	-1.1	-1.7	-1.1	-1.2	1.2	1.4	0.2
Intermitt. access escalation Index	1.5	1.3	2.8	1.2	-1.0	-1.2	-0.6	-1.0	-1.3	0.9	1.2	1.7
Intermittent access day 1 total infusions	1.0	1.2	4.0	0.7	-1.1	-0.7	-1.4	-1.0	-1.0	0.5	0.8	2.0
Intermittent access day 15 total infusions	3.9	4.4	8.7	1.9	-2.2	-1.8	-2.9	-2.2	-1.9	1.7	1.9	2.0
Intermittent access terminal intake (last 3 days)	2.3	2.5	5.4	1.3	-1.7	-1.2	-2.3	-1.7	-1.4	1.2	1.4	1.8
Intermittent access total infusions	1.7	1.9	4.1	1.1	-1.5	-1.0	-2.0	-1.5	-1.2	0.9	1.1	1.7
Intermittent access day 1 locomotion	0.4	0.4	1.6	0.4	-0.6	-0.3	-0.9	-0.6	-0.5	-0.0	0.3	1.3
Intermittent access day 15 total locomotion	0.4	0.5	1.9	-0.2	-0.1	0.4	-1.4	-0.3	0.4	-0.8	-0.5	-0.9
Intermittent access total locomotion	0.6	0.6	1.6	0.7	-0.8	-0.6	-1.3	-0.9	-0.6	0.0	0.5	1.1
Intermittent access standard deviation	7.3	7.8	12.4	2.8	-2.9	-2.7	-3.5	-2.9	-2.6	2.4	2.7	2.3
Left kidney weight	6.2	17.5	25.4	4.5	-4.0	-4.3	-3.2	-4.3	-4.4	3.8	3.9	5.0
Right kidney weight	1.6	4.6	10.3	2.4	-1.8	-2.2	-1.2	-2.1	-2.4	1.7	1.7	3.2
Cocaine induced anxiety	0.1	0.1	0.6	-0.1	0.4	0.1	0.8	0.5	-0.0	0.0	-0.0	0.2
Post-drug Anxiety	0.8	0.8	2.5	-0.7	1.1	0.6	1.6	1.2	0.8	-0.6	-0.7	-0.4
Baseline Anxiety	0.0	0.0	0.1	0.1	0.0	-0.1	0.1	0.0	0.3	-0.0	0.0	-0.3
Tail length	0.5	1.5	3.0	1.7	-1.1	-1.5	-1.0	-1.2	-1.0	1.1	1.1	1.0
Length with tail	1.6	5.8	9.2	3.0	-2.2	-2.6	-1.7	-2.4	-2.4	2.1	2.2	2.7
Length without tail	2.4	5.3	8.0	2.6	-2.1	-2.3	-1.5	-2.3	-2.5	2.1	2.2	2.8
Times rat made contact with spout	1.7	2.0	2.5	-1.6	1.6	1.5	1.5	1.4	1.2	-1.2	-1.5	-1.0
Lifetime Intake	1.0	1.1	2.7	0.6	-1.2	-0.6	-1.6	-1.1	-0.9	0.6	0.9	1.5
Liver weight, left	4.3	6.9	8.8	3.0	-2.6	-2.8	-2.8	-2.7	-2.5	2.3	2.5	2.3
Liver weight, right	2.8	4.6	8.4	2.3	-2.0	-2.1	-1.5	-1.9	-2.4	1.9	1.9	2.9
Locomotor activity	8.3	13.2	15.3	3.8	-3.7	-3.7	-3.2	-3.5	-3.9	3.5	3.6	3.8
Locomotor testing distance	4.0	6.7	7.3	2.5	-2.7	-2.6	-2.6	-2.5	-2.7	2.6	2.7	2.3
Locomotor testing rearing	4.2	6.5	7.2	2.3	-2.7	-2.5	-2.6	-2.5	-2.6	2.7	2.7	2.4
Locomotion in novel chamber	2.8	3.4	4.1	1.8	-2.0	-2.0	-1.4	-1.7	-1.9	2.0	2.0	1.8
Locomotion in novel chamber post-restriction	0.8	1.0	2.5	0.9	-1.0	-0.9	-1.6	-1.1	-0.8	0.7	0.7	0.9
Fecal boli incidents, locomotor time 1	2.7	3.0	4.7	1.9	-1.8	-1.8	-1.4	-1.8	-2.2	1.5	1.9	0.9
Change in fecal boli incidents, locomotor task	3.2	3.0	4.6	-1.5	1.6	1.7	1.1	1.4	2.0	-2.1	-1.7	-2.2
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.5	0.5	-0.5	-0.6	-0.7	-0.6	-0.5	0.5	0.5	0.4
Bouts of movement, locomotor time 1	0.3	0.4	1.2	-0.3	0.4	0.7	-0.4	0.2	0.6	-1.1	-0.6	-0.6
Total resting periods, locomotor time 1	0.3	0.3	1.1	-0.3	0.4	0.6	-0.3	0.1	0.5	-1.1	-0.6	-0.5
Rest time, locomotor task time 1	1.3	1.4	2.6	-1.2	1.3	1.4	0.7	1.1	1.2	-1.6	-1.1	-0.9
Distance moved, locomotor task time 1	1.2	1.3	2.7	1.2	-1.1	-1.4	-0.6	-1.0	-1.2	1.6	1.1	0.7
Vertical activity count, locomotor time 1	2.1	2.2	3.9	1.6	-1.5	-1.8	-0.8	-1.3	-1.6	2.0	1.4	1.0
Time >=10cm from walls, locomotor time 2	0.2	0.2	1.5	-0.1	-0.0	0.0	0.2	0.1	-0.2	0.0	0.3	1.2
Bouts of movement, locomotor time 2	1.3	1.4	1.8	-1.0	1.3	1.2	0.9	1.2	1.2	-1.4	-1.3	-1.0
Total resting periods, locomotor time 2	2.0	2.2	3.0	-1.3	1.6	1.5	1.2	1.4	1.5	-1.7	-1.6	-1.3
Rest time, locomotor task time 2	2.5	2.9	5.0	-1.5	1.8	1.8	1.4	1.5	1.6	-2.2	-1.8	-1.6
Distance moved, locomotor task time 2	1.6	1.9	3.4	1.2	-1.4	-1.5	-1.2	-1.3	-1.4	1.9	1.4	0.9
Vertical activity count, locomotor time 2	2.8	3.0	5.5	1.8	-1.6	-2.0	-1.0	-1.4	-1.9	2.3	1.7	1.3
Light reinforcement 1	0.6	1.1	1.7	1.1	-0.9	-1.0	-0.5	-0.9	-1.2	1.1	1.0	1.3
Light reinforcement 2	0.4	0.6	0.9	0.7	-0.7	-0.7	-1.0	-0.6	-0.7	0.7	0.7	1.0
Bone: marrow area	2.2	4.9	7.5	2.5	-2.4	-2.3	-2.7	-2.4	-1.8	2.1	2.2	1.1
Bone: maximum diameter	3.6	6.6	8.0	2.8	-2.7	-2.7	-2.3	-2.6	-2.5	2.5	2.7	2.2
Bone: maximum force	3.0	5.1	5.7	2.4	-2.3	-2.4	-2.1	-2.3	-2.2	2.4	2.1	2.4
Bone: maximum moment	3.7	6.4	7.1	2.6	-2.7	-2.6	-2.4	-2.6	-2.4	2.7	2.4	2.4
Mean time between licks in bursts	0.3	0.4	0.5	0.7	-0.7	-0.6	-0.7	-0.5	-0.5	0.7	0.6	0.6
Mean num. licks in bursts	0.4	0.4	1.4	-0.5	0.5	0.5	0.3	0.5	0.8	-0.5	-0.6	-1.2
Cd content in liver	1.9	2.1	2.6	1.2	-1.6	-1.5	-1.5	-1.6	-1.6	1.4	1.3	1.2
Co content in liver	0.1	0.1	0.3	-0.4	0.2	0.3	0.2	0.6	0.3	-0.0	-0.4	-0.1
Cu content in liver	1.6	1.9	2.6	-1.6	1.5	1.5	1.5	1.6	1.2	-1.0	-1.6	-0.6
Fe content in liver	0.3	0.4	1.3	0.6	-0.4	-0.6	0.1	-0.6	-0.8	0.5	0.5	1.2
K content in liver	0.0	0.0	0.1	-0.1	0.2	0.1	-0.1	0.1	0.2	-0.1	-0.3	-0.2
Mg content in liver	0.0	0.0	0.1	0.2	-0.0	-0.1	-0.1	-0.1	-0.1	0.1	0.1	0.3
Mn content in liver	1.9	2.2	3.0	1.7	-1.5	-1.6	-1.2	-1.6	-1.6	1.2	1.6	1.0
Na content in liver	2.4	2.5	3.5	1.9	-1.5	-1.8	-1.5	-1.7	-1.6	1.5	1.3	1.6
Rb content in liver	0.0	0.1	0.1	0.1	0.2	0.1	0.4	0.2	0.0	-0.2	0.0	0.4
Se content in liver	0.6	0.8	1.5	-0.7	1.1	0.7	1.0	0.6	0.7	-1.2	-1.1	0.2
Sr content in liver	2.3	2.1	3.8	1.4	-1.6	-1.5	-1.9	-1.6	-1.2	1.5	1.4	0.3
Zn content in liver	0.6	0.6	2.5	0.4	-0.7	-0.5	-0.4	-0.4	-0.9	0.9	0.6	1.6
Bone: minimum diameter	1.1	2.1	3.7	1.9	-1.5	-1.6	-1.2	-1.5	-1.3	1.3	1.3	1.1
Time in familiar zone, hab. session 1	0.2	0.2	0.6	-0.5	0.4	0.4	0.8	0.5	0.1	-0.1	-0.3	0.3
Time in novel zone, hab. session 1	0.1	0.1	0.6	0.1	-0.0	-0.1	-0.2	-0.0	0.1	-0.1	-0.0	-0.8
Total zone transitions, hab. session 1	0.1	0.1	0.4	0.3	-0.3	-0.3	-0.1	-0.3	-0.4	0.6	0.3	-0.2
Total locomotion distance, hab. session 1	0.1	0.1	0.3	0.1	-0.2	-0.3	-0.1	-0.2	-0.3	0.5	0.2	0.3
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.2	-0.0	-0.1	0.2	0.0	-0.1	0.3	-0.0	0.2
Time in familiar zone, hab. session 2	0.8	0.8	2.1	-1.0	0.9	0.8	1.5	1.2	0.6	-0.4	-0.9	0.2
Time in novel zone, hab. session 2	0.1	0.1	0.7	-0.0	0.3	0.0	0.1	0.2	0.4	-0.1	-0.2	-0.8
Total zone transitions, hab. session 2	0.7	0.9	2.0	0.5	-1.0	-0.9	-1.4	-0.9	-0.7	1.3	0.8	-0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.4	-0.4	-0.2	-0.1	-0.4	-0.1	-0.1	0.6	0.1	0.1
Locomotion velocity, hab. session 2	0.3	0.4	1.1	0.0	-0.7	-0.5	-0.9	-0.6	-0.6	1.1	0.5	0.5
Novel to familiar place preference ratio	0.0	0.0	0.1	0.3	0.0	-0.0	-0.2	0.0	0.1	-0.3	-0.1	-0.0
Novelty place preference	0.1	0.1	0.2	0.5	-0.1	-0.2	-0.3	-0.1	-0.1	-0.2	0.0	0.1
Time in novel zone, NPP test	0.0	0.0	0.1	0.3	0.0	-0.1	-0.0	0.1	-0.1	-0.2	-0.1	0.2
Total zone transitions, NPP test	0.2	0.3	0.8	0.4	-0.6	-0.5	-0.9	-0.5	-0.5	0.6	0.5	-0.2
Total locomotion distance, NPP test	0.0	0.0	0.1	-0.3	0.0	0.1	-0.0	0.1	0.1	0.1	-0.2	-0.3
Locomotion velocity, NPP test	0.0	0.0	0.2	-0.0	-0.2	-0.1	-0.4	-0.2	-0.1	0.1	0.0	-0.3
Intraocular pressure	0.3	0.4	0.6	0.5	-0.6	-0.7	-0.8	-0.6	-0.5	0.8	0.4	0.5
Delta distance traveled before/after self-admin	0.1	0.2	0.3	-0.4	0.3	0.5	0.0	0.4	0.5	-0.1	-0.6	-0.5
Delta ambulatory time before/after self-admin	0.4	0.5	0.8	-0.8	0.6	0.8	0.0	0.6	0.7	-0.6	-0.9	-0.8
Parametrial fat weight	0.1	0.3	0.7	-0.3	0.6	0.4	0.1	0.3	0.7	-0.8	-0.6	-0.5
Pavlov. Cond. lever latency	0.1	0.1	0.8	0.5	0.2	-0.2	0.4	0.1	-0.2	0.0	0.0	0.9
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	-0.2	-0.1	-0.2	-0.1	-0.1	0.3	-0.0	-0.2
Pavlov. Cond. change in total contacts	0.2	0.2	0.9	-0.5	0.1	0.3	0.0	0.1	0.2	-0.2	-0.3	-1.0
Pavlov. Cond. index score	0.1	0.1	0.3	-0.1	-0.5	-0.3	-0.6	-0.4	-0.3	0.4	0.3	-0.5
Pavlov. Cond. latency score	0.1	0.1	0.4	-0.4	-0.3	-0.0	-0.4	-0.2	-0.0	0.2	0.1	-0.6
Pavlov. Cond. lever contacts	0.2	0.3	1.7	-0.7	0.0	0.3	-0.1	0.1	0.3	-0.1	-0.1	-1.3
Pavlov. Cond. magazine entry number	0.8	0.9	1.5	-0.8	1.1	1.0	0.9	1.0	1.1	-1.2	-0.9	-0.7
Pavlov. Cond. intertrial magazine entries	7.1	8.7	11.2	-3.0	3.1	3.2	3.0	3.0	2.8	-3.4	-2.8	-2.0
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.5	-0.2	-0.2	-0.1	-0.3	-0.2	-0.1	0.2	0.1	-0.7
Pavlov. Cond. response bias	0.1	0.2	0.3	0.2	-0.5	-0.4	-0.4	-0.5	-0.5	0.6	0.3	-0.1
Pavlov. Cond. lever latency	0.7	0.9	1.6	-1.3	0.9	1.1	1.0	0.8	0.8	-1.1	-0.7	-0.9
Pavlov. Cond. magazine entry latency	0.1	0.1	0.7	0.4	0.0	-0.2	-0.1	-0.0	0.0	-0.1	-0.1	-0.8
Pavlov. Cond. change in total contacts	1.8	2.5	4.0	2.0	-1.6	-1.7	-1.7	-1.5	-1.5	1.5	1.4	1.2
Pavlov. Cond. index score	0.2	0.3	0.8	0.9	-0.5	-0.7	-0.5	-0.4	-0.4	0.5	0.3	0.3
Pavlov. Cond. latency score	0.1	0.1	0.4	0.7	-0.3	-0.4	-0.3	-0.2	-0.2	0.3	0.1	0.2
Pavlov. Cond. lever contacts	1.2	1.6	2.9	1.7	-1.2	-1.4	-1.2	-1.1	-1.2	1.4	1.0	1.1
Pavlov. Cond. magazine entry number	0.4	0.5	1.3	-1.2	0.6	0.9	0.7	0.7	0.7	-0.6	-0.5	-0.6
Pavlov. Cond. intertrial magazine entries	0.9	1.2	1.6	-1.3	1.2	1.1	1.1	1.0	1.2	-1.1	-1.1	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	0.9	-0.5	-0.7	-0.6	-0.4	-0.5	0.6	0.4	0.3
Pavlov. Cond. response bias	1.0	1.4	2.6	1.6	-1.1	-1.3	-1.1	-1.0	-1.1	1.2	1.0	0.8
Time in closed arm before self-admin	3.0	3.4	5.9	1.7	-1.7	-1.8	-1.0	-1.5	-1.9	2.2	1.8	2.4
Time in closed arm after self-admin	0.3	0.3	0.7	0.3	-0.6	-0.3	-0.8	-0.7	-0.4	0.4	0.3	0.9
Time in open arm before self-admin	0.9	1.0	2.1	-0.8	0.9	1.0	0.3	0.7	1.2	-1.4	-1.1	-1.1
Time in open arm after self-admin	1.5	1.6	3.0	-0.9	1.3	1.2	0.8	1.1	1.4	-1.7	-1.2	-1.5
Bone: periosteal estimation	3.8	7.9	10.4	3.2	-3.0	-3.0	-2.9	-2.9	-2.6	2.7	2.8	2.1
Bone: periosteal perimeter	3.6	6.0	7.3	2.7	-2.6	-2.5	-2.4	-2.4	-2.3	2.4	2.4	2.1
Bone: post-yield work	0.9	1.2	2.9	1.2	-1.2	-1.1	-1.7	-1.3	-0.6	1.0	0.8	-0.1
Progressive ratio test 1 active lever presses	0.4	0.4	1.7	0.3	-0.7	-0.3	-1.3	-0.8	-0.4	0.0	0.4	0.6
Progressive ratio test 1 breakpoint	0.5	0.5	2.1	0.4	-0.8	-0.4	-1.4	-0.9	-0.5	0.1	0.5	0.6
Progressive ratio test 1 inactive lever presses	1.0	1.1	3.5	0.9	-1.2	-0.9	-1.9	-1.2	-0.9	0.7	0.9	0.4
Progressive ratio test 2 active lever presses	0.6	0.7	1.7	0.5	-0.9	-0.5	-1.3	-0.8	-0.8	0.5	0.6	1.0
Progressive ratio test 2 breakpoint	0.7	0.8	1.9	0.5	-1.0	-0.5	-1.4	-0.9	-0.9	0.5	0.7	1.1
Progressive ratio test 2 inactive lever presses	1.3	1.5	5.7	0.9	-1.3	-0.9	-2.4	-1.4	-1.0	0.8	0.9	0.4
Incentive Sensitization - Responses	0.5	0.5	0.9	0.5	-0.8	-0.6	-0.7	-0.6	-0.9	1.0	0.5	0.8
Incentive Sensitization - Breakpoint	0.6	0.6	1.0	0.6	-0.8	-0.7	-0.8	-0.7	-0.9	1.0	0.6	0.8
Sum of active levers in priming session hrs 5-6	0.4	0.3	0.8	0.9	-0.3	-0.7	0.1	-0.4	-0.5	0.5	0.6	0.9
Progressive ratio	0.1	0.1	0.8	0.2	-0.1	-0.1	-0.4	-0.1	0.2	-0.1	-0.1	-0.9
Food seeking constrained by brief footshock	0.2	0.3	0.9	-0.4	0.4	0.5	0.4	0.5	0.4	-0.4	-0.3	-1.0
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.1	0.1	0.1	0.4	0.2	-0.0	-0.0	0.1	0.2
Retroperitoneal fat weight	0.1	0.2	0.6	0.6	-0.0	-0.3	-0.4	-0.5	0.0	-0.2	0.1	0.8
Reaction time number correct	0.5	0.7	1.9	-0.7	0.8	0.7	0.2	0.7	1.2	-0.8	-0.7	-1.4
Reaction time mean minus median	0.3	0.4	0.9	0.4	-0.5	-0.6	-0.3	-0.6	-0.7	1.0	0.4	0.8
Reaction time mean minus median AUC	0.3	0.4	1.9	0.1	-0.3	-0.4	-0.1	-0.2	-0.5	0.8	0.1	1.4
Reaction time num false alarms	0.6	0.8	1.8	0.8	-1.0	-0.9	-1.3	-0.8	-0.7	1.0	1.0	-0.2
Reaction time num false alarms AUC	0.8	1.1	2.7	1.1	-1.1	-1.0	-1.6	-1.0	-0.6	1.0	1.1	-0.6
Reaction time trials correct on left	0.5	0.7	1.9	-0.7	0.8	0.7	0.2	0.7	1.2	-0.8	-0.7	-1.4
Reaction time trials on left	0.5	0.8	2.1	-0.7	0.8	0.7	0.2	0.7	1.3	-0.8	-0.8	-1.5
Reaction time mean	0.1	0.1	0.6	-0.0	0.1	-0.1	0.8	0.1	-0.2	0.5	-0.1	0.5
Reaction time mean AUC	0.2	0.2	1.0	-0.4	0.4	0.3	1.0	0.4	0.2	0.2	-0.4	0.3
Median of all reaction times	0.2	0.2	1.3	-0.3	0.4	0.3	1.1	0.4	0.2	0.1	-0.3	0.2
Reaction time omissions	0.3	0.4	1.4	0.5	-0.3	-0.4	-1.2	-0.6	0.2	0.4	0.1	-1.1
Reaction time false alarm rate	1.0	1.4	2.2	1.2	-1.4	-1.2	-1.5	-1.2	-1.1	1.2	1.3	0.0
Reaction time premature initiation rate	1.8	2.5	2.9	-1.7	1.6	1.7	1.7	1.7	1.6	-1.4	-1.7	-1.0
Reaction time premature initiations	2.3	3.2	4.3	-1.8	1.8	1.8	1.4	1.9	2.1	-1.7	-1.9	-1.6
Std. dev. reaction times	0.1	0.1	0.3	0.2	-0.1	-0.3	0.0	-0.3	-0.2	0.6	-0.0	0.4
Reaction time trials completed	0.5	0.8	2.1	-0.7	0.8	0.7	0.2	0.7	1.3	-0.8	-0.8	-1.5
Reaction time trials AUC	0.4	0.5	1.6	-0.5	0.6	0.5	0.1	0.6	1.0	-0.6	-0.6	-1.3
Run reversals in cocaine runway, females	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.3	-0.2	-0.3	0.5	0.2	0.3
Run reversals in cocaine runway, males	0.4	0.3	0.6	0.8	-0.5	-0.7	-0.4	-0.6	-0.7	0.3	0.6	0.6
Latency to leave start box in cocaine runway	1.0	1.0	2.7	-1.0	1.0	1.0	1.6	1.1	0.7	-1.1	-0.9	-0.0
Latency to leave start box in cocaine runway, F	0.1	0.2	0.4	0.3	-0.2	-0.3	0.6	0.1	-0.6	0.2	0.3	0.6
Latency to leave start box in cocaine runway, M	6.4	6.2	7.6	-2.7	2.6	2.7	2.5	2.5	2.5	-2.8	-2.5	-1.4
Std. dev. time between licks in bursts	0.5	0.6	0.8	0.7	-0.9	-0.7	-0.9	-0.6	-0.6	0.9	0.6	0.9
Total sessions with >9 infusions	2.2	2.4	3.2	1.3	-1.8	-1.3	-1.7	-1.7	-1.6	1.3	1.6	1.5
Short access day 1 total inactive lever presses	0.6	0.6	2.2	0.6	-0.9	-0.6	-1.5	-0.9	-0.5	0.5	0.5	0.6
Short access day 10 total inactive lever presses	2.9	3.2	4.8	1.8	-1.8	-1.9	-1.9	-1.6	-1.8	2.2	1.8	0.9
Short access day 1 total infusions	1.6	1.7	3.4	0.9	-1.5	-0.9	-1.5	-1.4	-1.3	0.8	1.3	1.8
Short access day 10 total infusions	0.4	0.5	1.1	0.4	-0.8	-0.4	-1.0	-0.7	-0.7	0.2	0.6	1.0
Short access total infusions	0.5	0.5	1.8	0.2	-0.8	-0.2	-1.0	-0.7	-0.6	0.0	0.6	1.3
Short access day 1 locomotion	0.5	0.6	1.3	0.6	-0.9	-0.6	-1.1	-0.9	-0.7	0.5	0.8	0.5
Short access day 10 total locomotion	3.9	4.4	5.9	2.1	-2.2	-2.0	-2.4	-2.2	-2.2	1.6	2.2	1.8
Short access total locomotion	2.5	2.6	5.1	1.4	-1.8	-1.4	-2.2	-1.9	-1.6	1.1	1.6	1.2
One hour access (0.3 mA shock)	3.0	3.5	6.3	1.7	-2.0	-1.7	-2.5	-1.8	-1.7	2.0	1.8	1.1
Compulsive drug intake	1.9	1.9	2.8	1.5	-1.2	-1.6	-0.9	-1.1	-1.6	1.7	1.4	1.2
One hour access (shock baseline)	1.0	1.2	3.1	0.9	-1.2	-0.8	-1.8	-1.2	-0.9	0.8	0.9	0.8
Social response proportion	0.2	0.3	0.9	-0.0	0.7	0.3	1.0	0.5	0.2	-0.5	-0.3	-0.5
Social responses	3.0	3.8	5.1	2.3	-1.9	-2.1	-1.7	-2.0	-2.1	1.9	2.2	1.3
Social time	0.2	0.3	0.7	0.8	-0.4	-0.6	-0.5	-0.6	-0.4	0.4	0.5	0.1
Soleus weight	4.1	11.9	14.1	3.7	-3.5	-3.6	-3.4	-3.8	-3.3	3.5	3.4	2.6
Bone: stiffness	4.9	7.8	8.8	2.9	-2.9	-2.9	-2.6	-3.0	-2.7	2.5	2.7	2.8
Tibialis anterior weight	2.4	8.4	9.7	3.0	-3.0	-3.0	-2.8	-3.1	-2.9	2.9	2.9	2.5
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.5	0.4	-0.3	-0.5	-0.7	-0.5	-0.2	0.1	0.6	-0.2
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.8	-0.5	0.2	0.5	-0.3	0.2	0.2	-0.8	-0.1	-0.9
Time to tail flick, test, before self-admin	0.6	0.6	2.2	0.6	-0.6	-0.6	-0.2	-0.6	-0.9	0.6	0.7	1.5
Time to tail flick, test, after self-admin	0.7	0.7	1.2	1.1	-0.6	-0.9	-0.1	-0.5	-1.0	1.0	0.8	1.0
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.0	-0.0	0.2	-0.1	-0.1	-0.1	-0.3	-0.0	0.0
Delta time to tail flick, test, before/after SA	0.1	0.0	0.2	0.3	-0.1	-0.3	0.0	0.0	-0.0	0.4	0.2	-0.2
Tibia length	1.4	3.8	5.4	2.1	-2.1	-2.0	-2.3	-2.2	-1.8	1.9	1.7	1.0
Ambulatory time before self-admin	3.0	3.1	5.5	1.6	-1.7	-1.7	-1.2	-1.5	-1.8	1.9	1.8	2.3
Ambulatory time after self-admin	2.3	2.5	3.7	1.5	-1.6	-1.6	-1.5	-1.5	-1.5	1.9	1.5	1.5
Bone: tissue strength	2.2	2.2	3.1	1.4	-1.6	-1.4	-1.8	-1.6	-1.4	1.5	1.6	0.6
Total heroin consumption	0.6	0.7	4.2	0.6	-0.3	-0.5	-0.1	-0.4	-0.7	0.4	0.5	2.0
Bone: trabecular number	0.5	0.8	1.1	0.9	-0.9	-1.1	-0.7	-0.9	-0.8	1.1	0.9	0.7
Bone: trabecular spacing	0.9	1.1	2.2	-1.0	1.1	1.2	0.7	0.9	1.0	-1.5	-1.0	-0.9
Bone: trabecular thickness	0.7	0.9	1.2	1.1	-0.9	-1.1	-0.5	-0.8	-1.0	1.1	0.9	0.9
Bone: trabecular tissue density	0.4	0.5	0.8	0.9	-0.7	-0.8	-0.7	-0.9	-0.7	0.6	0.7	0.4
Water consumed over 24 hours	1.7	2.0	3.3	-1.5	1.5	1.4	1.8	1.6	1.2	-1.0	-1.2	-1.2
Number of responses in last shaping day	0.3	0.3	1.0	0.4	-0.6	-0.4	-1.0	-0.6	-0.1	0.3	0.4	-0.7