Hub : Genes

Arsa

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Arsa 0.39 0.15 8.8e-05 0.19 0.11 0.13 0.15 3.1e-05 1.6e-03 6.3e-04 2.0e-04
2 PL gene expression Arsa 0.27 0.09 0.0e+00 0.28 0.27 0.27 0.28 3.1e-30 2.6e-29 7.9e-30 1.4e-30
3 LHb gene expression Arsa 0.32 0.13 3.1e-04 0.11 0.08 0.04 0.1 1.5e-03 5.4e-03 3.8e-02 2.3e-03
4 IL gene expression Arsa 0.28 0.13 1.0e-03 0.14 0.12 0.17 0.15 2.8e-04 7.3e-04 7.7e-05 1.5e-04
5 pVTA mRNA stability Arsa 0.02 0.02 8.1e-03 0 0.01 0 0 3.1e-01 7.6e-02 1.9e-01 2.1e-01
6 BLA gene expression Arsa 0.22 0.11 1.2e-05 0.04 0.06 0.03 0.06 3.9e-03 2.9e-04 1.0e-02 4.0e-04
7 IC gene expression Arsa 0.34 0.13 1.0e-08 0.15 0.21 0.19 0.2 5.8e-07 4.1e-09 3.1e-08 1.1e-08
8 Adipose gene expression Arsa 0.16 0.09 2.2e-07 0.04 0.05 0.04 0.04 3.9e-05 1.1e-06 9.0e-06 2.7e-05
9 PL mRNA stability Arsa 0.06 0.03 4.4e-06 0.03 0.05 0.05 0.04 5.7e-04 3.4e-06 9.0e-06 1.4e-05
10 NAcc gene expression Arsa 0.07 0.03 1.4e-09 0.04 0.06 0.06 0.06 3.3e-07 3.6e-10 4.6e-09 4.9e-10
11 Brain gene expression Arsa 0.22 0.08 0.0e+00 0.2 0.21 0.22 0.21 9.2e-19 3.1e-19 4.5e-20 1.7e-19
12 pVTA gene expression Arsa 0.1 0.06 1.5e-07 0.07 0.09 0.08 0.09 2.0e-06 1.4e-07 2.8e-07 9.2e-08
13 IC mRNA stability Arsa 0.09 0.06 5.1e-03 0.02 0.04 0.01 0.03 3.4e-02 7.0e-03 8.7e-02 1.6e-02
14 Liver gene expression Arsa 0.16 0.07 9.8e-11 0.08 0.05 0.06 0.07 3.0e-09 3.4e-06 1.2e-07 2.1e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.40.73.7-0.4-0.6-1.0-0.61.9-0.2-0.20.90.50.50.81.01.10.7
Area under the delay curve1.51.73.11.01.01.21.10.61.21.80.41.41.61.41.51.61.7
BMI with tail1.55.114.23.13.02.63.0-3.82.21.81.10.70.60.5-2.5-2.0-1.2
BMI without tail0.61.97.40.80.80.50.9-2.70.2-0.0-0.3-0.8-0.8-0.6-2.5-2.3-1.8
Body weight0.62.58.02.02.11.81.9-2.81.21.20.50.20.10.4-1.9-1.9-1.1
Weight adjusted by age1.32.04.21.82.01.62.1-1.61.51.61.11.00.81.5-0.9-0.80.2
Bone surface1.01.93.90.70.60.30.52.00.91.11.71.61.51.71.61.71.7
Bone volume0.81.44.80.30.3-0.2-0.02.20.40.61.31.21.11.31.71.61.5
Breakpoint value in progressive ratio session0.60.71.41.01.00.60.8-0.31.11.00.80.90.91.20.10.50.4
Number of licking bursts0.10.10.2-0.5-0.40.1-0.10.1-0.5-0.5-0.3-0.4-0.4-0.2-0.2-0.3-0.5
Context. condit. distance diff. score0.91.03.1-0.1-0.0-0.00.2-1.7-0.5-0.5-0.8-1.0-1.0-0.9-1.7-1.8-1.3
Locomotion velocity, session 10.10.20.60.70.60.50.5-0.50.30.4-0.20.10.1-0.1-0.1-0.3-0.3
Locomotion distance, session 10.50.73.0-0.3-0.3-0.0-0.31.30.00.5-0.50.50.60.31.71.41.1
Locomotion velocity, session 20.30.40.90.90.90.60.9-0.60.50.40.60.30.20.7-0.6-0.5-0.4
Locomotion distance, session 20.20.31.3-0.2-0.30.2-0.11.0-0.10.3-0.40.30.30.51.10.80.6
Locomotion velocity, session 32.42.84.1-2.0-2.0-1.5-1.5-0.8-1.7-1.9-1.3-1.9-1.8-1.6-1.5-1.4-1.9
Locomotion distance, session 30.30.30.5-0.7-0.7-0.6-0.60.3-0.7-0.7-0.5-0.6-0.5-0.6-0.2-0.1-0.4
Stereotopy head waving bouts, day 30.91.14.6-0.0-0.10.1-0.02.10.00.30.90.90.91.01.61.51.4
Stereotopy head waving duration, day 30.30.31.5-0.6-0.6-0.7-0.61.2-0.5-0.40.10.00.00.10.70.60.4
Locomotion velocity, session 71.01.02.5-0.6-0.6-0.5-0.7-0.4-1.1-1.4-0.4-1.2-1.2-1.1-1.4-1.2-1.6
Locomotion distance, session 70.30.41.2-0.2-0.2-0.0-0.2-0.8-0.4-0.4-0.9-0.7-0.6-1.1-0.7-0.7-0.8
Stereotopy head waving bouts, day 70.40.51.7-0.6-0.9-1.3-0.71.2-0.2-0.20.60.30.20.70.70.70.5
Stereotopy head waving duration, day 70.80.92.8-1.3-1.5-1.7-1.31.3-1.0-1.10.1-0.4-0.50.10.30.3-0.2
Locomotion velocity, session 80.50.62.40.1-0.2-0.7-0.1-0.6-0.3-0.80.5-0.6-0.7-0.2-1.5-1.1-1.3
Locomotion distance, session 80.30.41.10.70.50.81.0-1.00.40.7-0.10.10.10.3-0.7-0.7-0.2
Degree of sensitization distance0.91.02.11.41.41.31.5-1.21.21.00.80.70.60.6-0.5-0.40.0
Degree of sensitization stereotypy0.50.61.9-1.0-1.3-1.4-1.00.2-0.7-0.9-0.1-0.6-0.7-0.1-0.3-0.4-0.6
Conditioned locomotion0.20.31.00.3-0.00.40.3-0.6-0.4-0.4-0.2-0.5-0.6-0.2-0.7-1.0-0.5
Cocaine response after cond. corrected0.30.31.50.40.30.10.5-1.20.5-0.00.5-0.1-0.10.0-1.2-0.7-0.8
Cocaine response after cond. not corrected0.70.93.80.50.30.20.6-1.90.5-0.10.3-0.4-0.4-0.3-1.8-1.3-1.4
Cocaine response before conditioning0.30.41.40.60.40.50.6-1.20.30.20.0-0.2-0.2-0.4-0.9-0.8-0.8
Saline control response1.62.14.01.91.71.82.0-0.71.91.71.51.41.41.50.00.40.8
Bone: connectivity density0.40.62.5-0.8-0.8-1.2-0.71.6-0.4-0.50.70.20.10.40.60.80.5
Bone: cortical apparent density0.81.03.2-1.5-1.3-0.6-1.11.8-1.3-0.8-0.9-0.5-0.4-0.41.20.70.4
Bone: cortical area1.72.78.32.12.32.92.10.01.51.71.41.51.41.50.40.40.9
Bone: cortical porosity1.71.83.71.51.51.81.9-0.21.61.61.31.41.41.30.20.51.0
Bone: cortical porosity2.42.65.11.81.91.92.3-0.82.12.01.61.61.61.60.00.41.0
Bone: cortical thickness0.30.42.80.70.91.70.80.30.20.60.10.40.40.40.40.10.4
Bone: cortical thickness0.50.51.30.30.4-0.3-0.6-0.6-0.6-0.5-1.2-0.8-0.8-1.1-0.7-0.9-0.8
Bone: cortical tissue density0.70.92.6-1.5-1.3-0.7-1.11.6-1.2-0.8-0.9-0.5-0.5-0.51.10.60.3
Condit. Reinf. active minus inactive responses1.41.63.41.81.71.71.8-0.31.30.91.61.01.01.3-0.50.00.1
Condit. Reinf. active-inactive response ratio0.10.10.40.50.40.60.60.10.20.00.60.20.10.4-0.3-0.1-0.1
Condit. Reinf. active responses1.51.94.52.01.82.02.1-0.81.40.91.60.90.81.4-0.9-0.5-0.2
Condit. Reinf. inactive responses0.91.12.51.61.41.41.5-1.11.10.90.80.60.50.9-0.7-0.5-0.3
Incentive salience index mean2.32.96.62.42.22.52.6-0.61.81.42.01.41.21.8-0.6-0.10.3
Condit. Reinf. lever presses1.72.46.42.22.02.52.5-0.71.51.31.61.11.01.6-0.6-0.40.4
Condit. Reinf. active minus inactive responses2.02.64.01.92.00.80.91.01.71.71.62.02.01.61.51.81.8
Condit. Reinf. active-inactive response ratio0.40.50.90.91.00.40.20.70.70.60.70.80.90.30.71.00.8
Condit. Reinf. active responses2.53.56.72.52.61.41.60.32.22.21.72.12.21.81.11.51.8
Condit. Reinf. inactive responses0.91.22.61.61.61.21.4-0.71.41.50.51.01.00.90.20.20.7
Condit. Reinf. lever presses1.82.55.82.32.41.81.9-0.51.91.81.61.61.51.30.10.40.6
Condit. Reinf. lever reinforcers received2.73.86.62.52.61.51.70.52.22.21.82.22.21.91.21.61.9
Conditioned reinforcement - actives0.61.01.91.31.20.81.2-0.51.31.11.31.01.01.4-0.20.20.6
Conditioned reinforcement - inactives0.10.10.40.10.1-0.5-0.1-0.4-0.2-0.1-0.0-0.2-0.3-0.0-0.5-0.7-0.3
Conditioned locomotion0.70.93.71.21.10.81.1-1.91.00.80.30.20.2-0.0-1.3-1.0-0.7
Patch foraging indifference point 0 sec0.20.30.70.60.70.50.7-0.70.80.50.60.50.40.4-0.5-0.1-0.2
Patch foraging indifference point AUC2.73.86.61.82.01.31.61.31.82.31.72.22.22.41.91.82.6
Delay disc. indifference point, 0s delay4.34.78.72.52.33.02.8-0.12.52.42.32.32.32.50.61.21.2
Delay disc. indifference point, 16s delay0.90.92.50.80.90.80.90.40.91.10.71.01.11.60.90.91.2
Delay disc. indifference point, 2s delay6.77.512.12.32.12.32.11.82.83.31.93.23.42.52.83.53.3
Delay disc. indifference point, 24s delay0.10.20.60.30.50.60.6-0.80.20.3-0.3-0.1-0.00.3-0.4-0.4-0.2
Delay disc. indifference point, 4s delay1.31.42.80.90.81.51.20.61.01.60.21.21.31.11.31.31.7
Delay disc. indifference point, 8s delay0.30.41.5-0.10.00.2-0.10.40.20.7-0.70.40.6-0.11.21.20.9
Indifference point function ln k0.71.24.80.10.10.20.2-2.20.0-0.5-0.4-0.8-0.8-0.9-1.9-1.5-1.9
Indifference point function log k0.71.24.80.10.10.20.2-2.20.0-0.5-0.4-0.8-0.8-0.9-1.9-1.5-1.9
Patch foraging total patch changes 0 sec0.10.10.40.20.40.20.4-0.40.60.30.50.40.30.2-0.40.1-0.2
Patch foraging total patch changes 12 sec1.92.53.51.61.51.61.60.51.81.71.81.91.91.60.81.41.7
Patch foraging total patch changes 18 sec1.42.14.60.91.0-0.20.41.81.01.41.11.61.71.61.92.02.2
Patch foraging total patch changes 24 sec0.61.01.90.70.9-0.30.21.30.80.71.41.21.21.11.01.31.2
Patch foraging total patch changes 6 sec1.01.52.61.11.11.01.40.41.31.61.21.41.41.60.80.91.4
Patch foraging time to switch 0 sec0.10.30.8-0.5-0.9-0.5-0.50.9-0.7-0.8-0.1-0.4-0.4-0.10.10.10.1
Patch foraging water rate 0 sec0.20.42.3-0.00.4-0.0-0.0-1.50.00.0-0.5-0.4-0.5-0.8-0.8-1.0-0.9
Patch foraging water rate 12 sec0.40.84.60.51.00.50.7-2.10.80.40.1-0.0-0.0-0.3-1.1-1.0-1.1
Patch foraging water rate 18 sec1.32.07.3-0.10.1-0.8-0.4-2.7-0.1-0.7-0.5-1.1-1.2-1.3-2.3-2.0-2.4
Patch foraging water rate 24 sec0.91.24.0-0.8-0.5-1.0-0.6-2.0-0.3-0.6-0.9-1.0-1.0-1.1-1.5-1.4-1.7
Patch foraging water rate 6 sec0.30.42.1-0.10.10.00.1-1.50.0-0.1-0.5-0.5-0.5-0.7-0.8-1.0-0.9
Seeking ratio, delayed vs. immediate footshock0.30.41.1-0.5-1.0-0.9-0.91.0-0.6-0.60.1-0.2-0.20.20.20.4-0.1
Distance traveled before self-admin0.20.31.4-0.3-0.60.8-0.11.2-0.5-0.0-0.5-0.00.0-0.10.90.60.5
Distance traveled after self-admin0.20.31.0-0.6-1.0-0.1-0.4-0.0-0.6-0.7-0.4-0.6-0.5-0.5-0.5-0.2-0.6
Extensor digitorum longus weight0.10.62.40.20.20.10.2-1.1-0.3-0.3-0.4-0.7-0.8-0.3-1.2-1.6-0.9
Bone: elastic displacement0.20.20.6-0.7-0.6-0.6-0.30.10.40.20.10.30.40.20.50.70.4
Bone: elastic work0.10.20.50.50.60.30.5-0.60.60.70.20.30.30.5-0.1-0.30.2
Bone: endosteal estimation0.61.32.51.61.51.11.3-0.31.41.41.21.21.11.20.20.30.6
Bone: endosteal perimeter4.69.916.54.13.83.63.50.43.63.43.63.53.33.31.21.82.2
Epididymis fat weight1.55.110.53.13.23.23.1-1.22.61.92.91.91.91.9-1.00.00.2
Delta time in closed arm before/after self-admin0.20.20.50.40.30.40.5-0.30.70.7-0.10.50.6-0.00.20.50.7
Delta time in open arm before/after self-admin0.10.10.2-0.10.00.30.00.3-0.2-0.20.40.0-0.10.30.2-0.0-0.4
Diff in mean of infusions in LGA sessions2.02.54.12.02.01.41.9-0.62.01.72.01.61.61.9-0.10.50.8
Delay discount exponential model param1.01.12.1-0.7-0.7-0.9-0.8-0.5-0.9-1.5-0.1-1.1-1.3-1.0-1.3-1.4-1.5
Extinction: sum of active levers before priming1.11.32.50.90.60.80.90.21.31.31.11.31.51.60.61.41.1
Active lever presses in extinction session 60.60.62.80.80.60.20.7-1.70.70.50.40.10.10.4-1.3-0.8-0.7
Bone: final force0.30.42.40.80.71.60.80.60.00.6-0.10.40.30.50.50.00.7
Bone: final moment0.20.31.60.50.41.30.50.7-0.10.5-0.20.30.10.40.60.00.7
Food consumed during 24 hour testing period0.60.82.81.10.80.70.9-1.70.40.10.2-0.3-0.3-0.0-1.6-1.3-1.0
Glucose0.40.61.10.60.70.40.50.30.91.00.60.91.00.80.90.90.8
Heart weight0.40.71.5-0.6-0.4-0.2-0.5-0.7-0.8-0.9-0.6-1.0-1.0-0.9-0.9-1.1-1.2
Delay discount hyperbolic model param1.31.52.9-0.8-0.8-1.1-0.9-0.7-1.0-1.6-0.2-1.3-1.5-1.1-1.6-1.6-1.7
Intermittent access intake day 1-15 change0.20.51.00.80.80.30.8-0.91.00.70.90.60.60.7-0.6-0.20.0
Intermittent access intake escalation0.30.61.20.90.90.40.9-0.91.10.71.10.70.70.8-0.6-0.1-0.0
Intermittent access intake escalation 22.32.66.12.01.81.31.9-0.72.11.62.51.71.62.0-0.40.30.7
Intermitt. access day 1 inactive lever presses0.20.81.81.21.30.71.0-0.71.01.20.80.80.71.1-0.1-0.20.2
Intermitt. access day 15 inactive lever presses0.91.85.1-0.4-0.3-0.9-0.3-2.1-0.6-1.0-0.5-1.3-1.4-1.1-2.1-2.2-1.7
Intermitt. access escalation Index0.30.41.0-1.0-0.9-0.7-1.00.4-0.5-0.9-0.4-0.5-0.3-0.90.00.4-0.3
Intermittent access day 1 total infusions0.10.20.7-0.4-0.4-0.5-0.4-0.5-0.3-0.4-0.6-0.5-0.4-0.8-0.4-0.2-0.5
Intermittent access day 15 total infusions0.10.10.60.10.1-0.4-0.0-0.70.40.10.10.10.2-0.2-0.4-0.1-0.2
Intermittent access terminal intake (last 3 days)0.60.82.01.21.10.51.1-1.31.40.91.10.80.80.6-0.7-0.10.0
Intermittent access total infusions0.10.10.50.40.4-0.00.3-0.70.70.40.20.30.4-0.1-0.30.2-0.1
Intermittent access day 1 locomotion0.10.10.30.30.30.30.3-0.20.60.40.20.40.5-0.20.20.60.2
Intermittent access day 15 total locomotion0.40.71.51.21.20.81.1-1.21.21.10.40.60.70.2-0.4-0.2-0.0
Intermittent access total locomotion0.20.31.60.50.50.20.5-1.30.70.40.00.10.2-0.3-0.7-0.4-0.4
Intermittent access standard deviation0.30.61.1-0.5-0.5-0.7-0.6-0.8-0.6-0.8-0.3-0.8-0.9-0.4-1.0-1.0-1.0
Left kidney weight1.57.019.93.13.02.83.6-4.52.61.72.20.90.61.6-3.4-2.6-1.6
Right kidney weight2.19.533.83.43.32.93.8-5.82.71.71.80.40.21.1-4.4-3.7-2.5
Cocaine induced anxiety0.30.41.9-0.2-0.20.60.4-1.40.2-0.50.2-0.4-0.3-0.4-1.3-0.7-0.9
Post-drug Anxiety0.80.82.4-0.4-0.50.60.2-1.5-0.3-0.9-0.3-0.9-0.9-1.0-1.6-1.3-1.1
Baseline Anxiety0.30.30.7-0.6-0.6-0.8-0.70.7-0.8-0.5-0.6-0.4-0.5-0.40.4-0.10.2
Tail length0.20.72.3-1.2-1.1-1.1-1.11.5-1.0-0.80.1-0.3-0.40.10.60.40.3
Length with tail0.00.20.60.30.40.50.30.30.20.40.60.50.40.80.30.20.4
Length without tail0.72.44.11.91.92.01.9-0.61.91.81.61.61.61.50.40.60.8
Times rat made contact with spout3.54.05.1-1.7-1.8-2.1-1.8-2.1-1.6-1.8-2.1-2.2-2.1-2.2-2.0-2.0-2.2
Lifetime Intake0.10.10.80.30.2-0.10.1-0.90.50.3-0.10.00.2-0.3-0.4-0.1-0.3
Liver weight, left0.81.32.71.51.61.61.5-0.31.21.60.61.11.01.20.40.20.8
Liver weight, right0.20.41.00.60.60.50.5-0.00.71.00.10.70.80.30.70.70.8
Locomotor activity1.62.64.61.71.71.91.9-0.32.11.91.81.81.81.60.51.01.1
Locomotor testing distance0.10.31.0-0.3-0.5-0.0-0.30.70.20.2-0.10.40.40.10.91.00.7
Locomotor testing rearing2.75.58.32.42.31.91.90.82.82.92.02.82.92.12.22.42.7
Locomotion in novel chamber2.93.76.4-1.2-1.4-2.3-1.7-1.6-1.8-1.8-1.5-2.2-2.3-1.9-2.1-2.5-2.3
Locomotion in novel chamber post-restriction0.50.81.50.70.40.20.80.71.00.81.21.11.11.00.51.01.2
Fecal boli incidents, locomotor time 10.10.20.4-0.6-0.6-0.3-0.60.4-0.3-0.1-0.6-0.2-0.0-0.50.50.50.1
Change in fecal boli incidents, locomotor task0.20.20.30.30.40.50.5-0.60.50.20.50.20.10.3-0.5-0.3-0.3
Time >=10cm from walls, locomotor time 10.70.81.80.90.91.31.2-0.10.80.71.40.80.71.2-0.20.00.2
Bouts of movement, locomotor time 10.50.51.8-0.3-0.6-1.3-0.7-0.2-0.7-0.9-0.1-0.7-0.8-0.1-0.9-1.0-0.7
Total resting periods, locomotor time 10.60.72.8-0.6-0.8-1.7-0.90.1-0.9-1.0-0.4-0.8-0.9-0.2-0.6-0.8-0.5
Rest time, locomotor task time 11.62.05.6-1.5-1.6-2.4-1.8-0.3-1.4-1.5-1.5-1.5-1.4-1.6-0.7-0.8-0.9
Distance moved, locomotor task time 10.91.43.91.31.32.01.5-0.11.41.11.41.21.21.00.20.60.4
Vertical activity count, locomotor time 11.12.66.42.02.02.52.1-0.41.81.71.91.61.51.50.10.50.4
Time >=10cm from walls, locomotor time 20.91.42.91.51.61.51.7-1.11.41.11.30.90.81.2-0.7-0.4-0.3
Bouts of movement, locomotor time 20.10.20.7-0.3-0.5-0.8-0.90.5-0.5-0.3-0.4-0.2-0.2-0.20.40.20.0
Total resting periods, locomotor time 20.10.20.6-0.2-0.4-0.8-0.70.7-0.4-0.1-0.2-0.10.0-0.10.50.40.2
Rest time, locomotor task time 21.31.63.6-1.6-1.7-1.8-1.90.4-1.4-1.4-1.2-1.1-1.0-1.60.00.1-0.9
Distance moved, locomotor task time 21.72.04.22.01.91.82.1-1.01.81.61.31.21.11.4-0.4-0.10.3
Vertical activity count, locomotor time 21.62.34.52.02.01.82.1-1.01.81.71.41.31.31.5-0.2-0.10.7
Light reinforcement 10.71.83.71.71.71.21.6-0.71.91.41.71.51.51.2-0.00.70.5
Light reinforcement 22.94.58.32.82.82.42.7-1.52.92.42.32.12.01.8-0.40.40.6
Bone: marrow area0.51.22.21.51.41.11.2-0.11.31.31.11.21.11.20.30.30.7
Bone: maximum diameter1.63.09.12.42.43.02.4-0.71.91.61.71.41.31.4-0.30.10.5
Bone: maximum force0.10.21.30.60.61.20.60.20.00.6-0.20.20.10.40.3-0.30.5
Bone: maximum moment0.10.10.60.20.30.80.30.3-0.20.4-0.40.0-0.10.20.3-0.30.4
Mean time between licks in bursts1.02.45.0-1.9-1.9-1.5-2.01.7-2.2-1.7-1.8-1.4-1.4-1.30.8-0.1-0.2
Mean num. licks in bursts0.40.61.8-0.6-0.7-1.4-1.0-1.1-0.4-0.5-0.9-0.7-0.6-0.9-0.7-0.5-0.6
Cd content in liver0.30.41.00.20.4-0.6-0.30.60.40.60.10.60.70.20.90.91.0
Co content in liver0.91.02.10.81.11.31.5-0.31.41.01.41.11.01.10.00.40.4
Cu content in liver3.44.06.9-2.2-2.1-1.8-2.30.0-2.4-2.4-2.5-2.3-2.2-2.6-0.6-1.0-1.6
Fe content in liver0.60.71.30.60.70.80.70.21.11.10.51.01.20.41.01.21.1
K content in liver0.10.10.7-0.0-0.2-0.2-0.20.8-0.2-0.50.70.10.00.30.20.30.0
Mg content in liver0.70.71.40.20.00.50.41.20.60.41.10.90.91.11.11.21.0
Mn content in liver0.30.31.80.40.40.30.30.60.50.21.30.70.60.90.20.40.2
Na content in liver2.32.48.50.40.5-0.6-0.52.90.30.71.01.41.51.32.72.42.1
Rb content in liver0.80.91.50.80.90.90.90.21.21.01.11.11.20.90.61.01.0
Se content in liver0.20.30.8-0.3-0.4-0.9-0.4-0.6-0.1-0.50.1-0.4-0.4-0.4-0.9-0.5-0.6
Sr content in liver1.31.22.1-1.4-1.3-1.1-1.40.9-1.4-1.2-1.3-1.0-0.9-1.20.40.0-0.3
Zn content in liver1.41.52.9-1.5-1.6-1.1-1.4-0.0-1.4-1.3-1.7-1.4-1.3-1.6-0.1-0.5-0.7
Bone: minimum diameter1.12.05.22.12.02.31.80.11.41.41.31.31.21.20.30.40.7
Time in familiar zone, hab. session 11.21.21.8-1.2-1.1-1.0-0.9-1.1-0.8-1.0-1.0-1.2-1.2-1.0-1.1-1.1-1.3
Time in novel zone, hab. session 10.90.92.00.60.70.50.61.30.70.80.91.11.10.81.21.21.4
Total zone transitions, hab. session 10.60.83.4-0.5-0.6-0.5-0.71.6-0.40.5-0.70.40.40.51.81.21.3
Total locomotion distance, hab. session 10.50.71.70.60.50.80.7-0.00.91.30.10.90.91.20.90.61.0
Locomotion velocity, hab. session 10.71.02.20.80.71.10.90.21.11.50.31.11.11.31.20.91.2
Time in familiar zone, hab. session 21.01.13.1-0.5-0.5-0.2-0.3-1.4-0.6-1.1-0.4-1.1-1.1-1.0-1.8-1.4-1.6
Time in novel zone, hab. session 20.60.62.2-0.4-0.3-0.6-0.31.5-0.00.30.10.50.50.41.41.11.2
Total zone transitions, hab. session 20.20.21.0-0.1-0.3-0.1-0.1-0.9-0.10.0-1.0-0.5-0.4-0.4-0.3-0.5-0.5
Total locomotion distance, hab. session 20.40.52.80.60.60.91.0-1.70.80.8-0.30.10.10.2-0.6-0.7-0.2
Locomotion velocity, hab. session 20.50.62.50.70.71.01.1-1.60.91.0-0.20.30.30.4-0.5-0.5-0.1
Novel to familiar place preference ratio1.01.12.3-1.3-1.4-1.1-1.20.5-1.3-1.5-0.6-1.1-1.1-1.0-0.5-0.5-0.9
Novelty place preference1.11.22.4-1.3-1.4-1.1-1.20.2-1.3-1.6-0.6-1.2-1.2-1.1-0.7-0.6-1.0
Time in novel zone, NPP test1.71.83.3-1.6-1.7-1.4-1.50.2-1.6-1.8-0.8-1.4-1.4-1.4-0.8-0.8-1.2
Total zone transitions, NPP test0.20.30.9-0.5-0.8-0.9-0.80.5-0.50.0-0.9-0.2-0.2-0.30.80.30.3
Total locomotion distance, NPP test0.30.41.20.70.50.60.8-0.30.81.10.20.70.70.80.50.40.7
Locomotion velocity, NPP test0.30.51.20.80.60.80.9-0.40.81.10.20.70.70.80.40.30.6
Intraocular pressure1.31.92.91.71.61.51.40.31.71.70.91.51.60.90.91.31.3
Delta distance traveled before/after self-admin1.41.44.8-0.4-0.4-0.9-0.3-2.0-0.3-1.0-0.2-1.1-1.1-0.8-2.2-1.7-1.8
Delta ambulatory time before/after self-admin0.91.13.3-0.4-0.5-1.0-0.4-1.6-0.4-1.0-0.4-1.1-1.1-0.9-1.8-1.5-1.4
Parametrial fat weight0.30.61.91.31.31.41.0-0.60.50.90.00.40.30.1-0.1-0.40.1
Pavlov. Cond. lever latency1.31.64.5-1.8-1.7-2.1-2.10.8-1.2-1.1-1.1-0.8-0.8-1.20.60.4-0.3
Pavlov. Cond. magazine entry latency0.10.20.70.30.30.60.40.90.1-0.00.50.30.40.30.40.60.4
Pavlov. Cond. change in total contacts1.31.44.21.61.52.01.50.80.90.91.01.01.01.00.60.70.8
Pavlov. Cond. index score0.30.41.60.90.81.31.00.40.40.40.60.50.50.60.10.20.4
Pavlov. Cond. latency score0.50.62.31.11.01.51.20.30.60.50.80.60.50.8-0.00.10.4
Pavlov. Cond. lever contacts1.21.44.31.71.52.12.0-0.51.10.91.10.80.71.1-0.6-0.30.3
Pavlov. Cond. magazine entry number0.30.40.9-0.5-0.4-0.9-0.6-0.9-0.4-0.2-0.5-0.6-0.7-0.3-0.6-0.9-0.7
Pavlov. Cond. intertrial magazine entries1.01.12.61.61.51.01.4-1.01.41.21.00.90.90.9-0.4-0.10.1
Pavlov. Cond. lever-magazine prob. diff.0.40.41.70.90.81.31.00.60.40.40.50.50.50.60.30.40.6
Pavlov. Cond. response bias0.40.51.81.00.81.41.2-0.00.70.50.70.60.60.6-0.10.20.3
Pavlov. Cond. lever latency0.40.61.3-1.1-1.1-0.8-0.71.1-0.6-0.3-0.6-0.1-0.10.01.10.70.8
Pavlov. Cond. magazine entry latency0.30.41.50.90.91.20.7-0.50.20.10.40.1-0.00.3-0.4-0.6-0.7
Pavlov. Cond. change in total contacts0.81.33.01.61.71.41.00.31.21.31.11.31.21.00.60.70.8
Pavlov. Cond. index score0.50.61.81.21.31.30.9-0.70.70.60.60.40.30.4-0.5-0.4-0.5
Pavlov. Cond. latency score0.50.71.71.31.31.31.0-1.00.60.50.70.30.20.4-0.8-0.7-0.8
Pavlov. Cond. lever contacts0.40.61.51.21.20.60.7-1.20.70.40.60.20.20.1-1.0-0.7-0.8
Pavlov. Cond. magazine entry number0.50.61.7-1.2-1.3-1.3-0.90.7-0.4-0.4-0.5-0.2-0.1-0.50.50.70.6
Pavlov. Cond. intertrial magazine entries0.40.62.2-1.2-1.1-1.5-0.8-0.8-0.2-0.5-0.6-0.5-0.4-0.7-0.5-0.1-0.3
Pavlov. Cond. lever-magazine prob. diff.0.50.61.71.21.31.30.9-0.80.60.50.60.40.30.3-0.5-0.5-0.6
Pavlov. Cond. response bias0.30.41.11.11.11.00.7-0.40.60.40.70.40.30.2-0.4-0.2-0.4
Time in closed arm before self-admin2.53.24.91.41.41.51.32.11.51.42.22.12.02.01.82.11.9
Time in closed arm after self-admin3.74.05.62.11.92.12.00.92.32.21.92.32.42.01.32.02.0
Time in open arm before self-admin1.01.12.0-0.9-1.1-1.4-1.1-0.3-1.3-1.0-1.4-1.2-1.2-0.8-0.7-1.0-0.4
Time in open arm after self-admin0.10.20.4-0.3-0.4-0.6-0.5-0.2-0.4-0.4-0.2-0.4-0.4-0.2-0.3-0.4-0.6
Bone: periosteal estimation1.43.06.42.42.42.52.1-0.11.92.01.61.71.61.70.40.51.0
Bone: periosteal perimeter3.76.311.93.33.33.53.0-0.02.82.62.82.62.42.60.51.01.4
Bone: post-yield work0.71.02.7-1.2-1.1-0.6-1.20.5-1.3-0.8-1.6-0.9-0.9-1.40.4-0.1-0.1
Progressive ratio test 1 active lever presses1.01.21.8-1.1-1.2-1.1-1.1-0.4-1.3-1.2-1.3-1.3-1.3-1.0-0.8-1.0-1.1
Progressive ratio test 1 breakpoint0.91.11.6-1.1-1.2-1.1-1.1-0.3-1.2-1.2-1.2-1.3-1.2-1.0-0.7-0.9-1.0
Progressive ratio test 1 inactive lever presses0.10.10.30.40.30.40.4-0.20.30.20.50.20.20.5-0.2-0.10.0
Progressive ratio test 2 active lever presses0.20.21.20.50.4-0.20.4-1.10.40.30.1-0.0-0.00.3-0.8-0.7-0.4
Progressive ratio test 2 breakpoint0.20.20.90.50.4-0.20.3-0.90.40.30.1-0.00.00.3-0.7-0.6-0.3
Progressive ratio test 2 inactive lever presses0.30.41.20.90.90.40.9-1.10.80.80.50.40.40.3-0.6-0.5-0.0
Incentive Sensitization - Responses1.01.42.61.61.61.01.5-0.91.51.41.21.11.01.3-0.4-0.10.5
Incentive Sensitization - Breakpoint1.01.32.41.51.50.91.5-0.91.41.31.11.01.01.2-0.3-0.10.5
Sum of active levers in priming session hrs 5-60.30.30.80.50.40.60.7-0.00.60.40.80.50.60.9-0.10.40.4
Progressive ratio0.10.21.00.1-0.40.20.3-0.5-0.1-0.3-0.0-0.4-0.4-0.1-1.0-0.6-0.4
Food seeking constrained by brief footshock1.01.35.71.21.01.21.5-2.41.21.10.00.20.30.3-1.2-1.0-0.4
Seeking ratio, punishment vs. effort0.50.81.60.91.21.00.9-0.21.11.20.50.91.00.60.80.60.6
Retroperitoneal fat weight1.25.011.23.13.33.03.3-2.82.52.21.51.31.21.2-1.6-1.1-0.2
Reaction time number correct0.10.20.6-0.2-0.5-0.8-0.50.4-0.20.0-0.8-0.1-0.0-0.30.70.50.6
Reaction time mean minus median0.10.31.30.60.61.10.7-0.00.40.40.50.40.40.3-0.10.10.0
Reaction time mean minus median AUC0.00.10.10.30.20.30.2-0.30.20.10.30.10.00.1-0.4-0.2-0.4
Reaction time num false alarms0.10.10.60.1-0.0-0.2-0.00.80.0-0.10.60.20.20.60.20.40.3
Reaction time num false alarms AUC0.10.10.4-0.3-0.4-0.7-0.40.3-0.4-0.5-0.1-0.3-0.3-0.1-0.3-0.1-0.2
Reaction time trials correct on left0.10.20.6-0.2-0.5-0.8-0.50.4-0.20.0-0.8-0.1-0.0-0.30.70.50.6
Reaction time trials on left0.10.20.7-0.3-0.5-0.8-0.60.5-0.3-0.1-0.8-0.2-0.1-0.30.70.40.5
Reaction time mean1.01.62.8-1.4-1.3-1.1-1.50.2-1.7-1.6-1.1-1.4-1.4-1.2-0.5-0.8-1.3
Reaction time mean AUC0.91.42.5-1.4-1.2-1.2-1.50.4-1.6-1.5-1.1-1.3-1.3-1.1-0.4-0.7-1.1
Median of all reaction times2.33.25.2-2.1-1.9-1.9-2.20.2-2.3-2.3-1.6-2.0-2.0-1.7-0.8-1.2-1.7
Reaction time omissions0.71.02.0-1.0-1.1-1.3-1.30.8-1.4-1.1-1.0-1.0-1.1-0.9-0.0-0.5-0.5
Reaction time false alarm rate0.00.10.30.00.0-0.1-0.00.3-0.1-0.30.5-0.0-0.10.3-0.4-0.1-0.2
Reaction time premature initiation rate4.25.89.83.13.12.63.1-0.92.92.53.02.42.33.1-0.20.61.0
Reaction time premature initiations1.83.25.82.42.21.62.2-0.52.22.02.01.81.82.40.20.61.1
Std. dev. reaction times0.10.30.6-0.1-0.10.3-0.2-0.3-0.6-0.5-0.5-0.6-0.7-0.6-0.5-0.8-0.8
Reaction time trials completed0.10.20.7-0.3-0.5-0.8-0.60.5-0.3-0.1-0.8-0.2-0.1-0.30.70.40.5
Reaction time trials AUC0.10.20.7-0.1-0.4-0.7-0.40.3-0.3-0.0-0.8-0.2-0.1-0.30.50.30.4
Run reversals in cocaine runway, females0.50.50.8-0.7-0.7-0.6-0.6-0.4-0.7-0.8-0.7-0.8-0.9-0.8-0.7-0.8-0.9
Run reversals in cocaine runway, males0.80.82.40.50.60.40.40.51.11.10.11.01.20.11.31.51.2
Latency to leave start box in cocaine runway1.21.44.00.1-0.0-0.3-0.0-2.0-0.5-0.4-1.3-1.2-1.3-1.2-1.6-2.0-1.3
Latency to leave start box in cocaine runway, F3.54.09.6-1.0-1.0-1.3-0.9-2.3-1.6-1.9-1.5-2.3-2.5-1.6-2.8-3.1-2.5
Latency to leave start box in cocaine runway, M1.41.33.11.41.41.61.3-0.31.41.80.01.11.20.11.00.81.0
Std. dev. time between licks in bursts1.21.63.11.71.81.51.8-1.11.51.70.71.11.01.1-0.0-0.10.5
Total sessions with >9 infusions0.50.61.6-0.4-0.4-0.5-0.5-1.2-0.5-0.3-1.3-0.9-0.8-0.9-0.7-0.9-1.0
Short access day 1 total inactive lever presses1.31.76.40.30.30.50.7-2.5-0.1-0.4-0.6-1.0-1.1-0.5-2.2-2.4-1.7
Short access day 10 total inactive lever presses1.43.46.82.32.52.22.6-2.22.01.52.11.10.91.7-1.6-1.3-0.4
Short access day 1 total infusions0.81.13.0-0.3-0.3-0.7-0.4-1.7-0.5-0.5-1.2-1.1-1.1-1.0-1.3-1.5-1.4
Short access day 10 total infusions0.30.42.30.20.2-0.20.1-1.50.40.0-0.3-0.3-0.2-0.7-1.0-0.6-0.9
Short access total infusions0.30.42.40.10.1-0.20.0-1.60.20.1-0.7-0.5-0.3-0.8-0.9-0.7-0.9
Short access day 1 locomotion0.70.82.2-0.3-0.3-0.8-0.5-1.5-0.4-0.5-0.7-0.9-0.9-0.6-1.3-1.3-1.4
Short access day 10 total locomotion0.20.42.00.40.40.30.4-1.40.30.2-0.4-0.3-0.2-0.2-0.9-0.9-0.9
Short access total locomotion0.20.31.40.30.20.10.1-1.20.20.2-0.5-0.3-0.2-0.4-0.7-0.6-0.8
One hour access (0.3 mA shock)1.31.53.41.51.40.91.4-0.91.81.31.71.41.41.1-0.30.50.4
Compulsive drug intake0.10.10.40.20.20.10.1-0.00.50.20.30.40.5-0.50.20.60.0
One hour access (shock baseline)0.50.81.51.11.10.30.9-0.71.21.01.10.90.91.2-0.20.20.4
Social response proportion0.50.61.20.80.61.10.60.80.60.60.50.80.80.40.81.00.8
Social responses0.60.71.11.00.81.00.70.60.90.80.91.01.00.70.71.00.7
Social time0.91.21.9-0.6-1.0-0.5-0.6-1.2-1.0-1.1-1.2-1.4-1.3-1.3-1.3-1.3-1.1
Soleus weight0.31.03.50.70.50.20.3-1.9-0.0-0.1-0.4-0.7-0.8-0.4-1.6-1.8-1.5
Bone: stiffness0.10.20.6-0.1-0.10.6-0.10.6-0.8-0.2-0.7-0.4-0.5-0.00.3-0.40.1
Tibialis anterior weight0.00.10.50.0-0.1-0.3-0.2-0.1-0.4-0.3-0.2-0.4-0.5-0.3-0.6-0.7-0.4
Time to tail flick, vehicle, before self-admin1.11.12.31.51.51.21.5-0.80.91.01.10.70.51.3-0.5-0.7-0.0
Time to tail flick, vehicle, after self-admin0.30.41.30.80.90.40.7-0.50.70.41.10.50.50.9-0.5-0.2-0.0
Time to tail flick, test, before self-admin0.30.31.10.50.51.00.80.00.30.01.00.30.20.5-0.6-0.2-0.1
Time to tail flick, test, after self-admin1.21.34.5-0.00.0-0.4-0.0-1.8-0.6-0.7-0.2-1.1-1.2-0.1-1.9-2.1-1.7
Delta time to tail flick, vehicle, before/after SA0.50.41.7-0.8-0.8-1.3-1.10.6-0.5-0.6-0.5-0.3-0.2-0.40.40.50.1
Delta time to tail flick, test, before/after SA0.60.61.3-0.5-0.4-0.9-0.6-1.0-0.7-0.4-1.1-0.9-0.9-0.4-0.6-1.2-0.9
Tibia length0.41.03.4-0.9-0.6-1.0-1.31.5-0.6-0.0-0.80.10.3-0.21.81.41.1
Ambulatory time before self-admin0.20.40.9-0.7-1.00.5-0.40.3-0.8-0.6-0.9-0.6-0.6-0.70.1-0.1-0.3
Ambulatory time after self-admin0.50.51.0-0.7-1.0-0.3-0.4-0.5-0.7-1.0-0.5-0.9-0.8-0.6-1.0-0.6-0.8
Bone: tissue strength1.51.54.2-2.0-2.0-1.7-1.40.2-1.4-0.8-1.6-1.1-1.1-0.80.2-0.50.1
Total heroin consumption0.40.51.30.90.9-0.10.4-0.41.00.90.60.70.81.10.20.50.4
Bone: trabecular number0.40.72.7-0.7-0.7-1.5-0.81.6-0.3-0.40.90.30.20.60.70.80.5
Bone: trabecular spacing0.81.14.60.80.81.71.3-2.10.50.5-0.5-0.2-0.2-0.1-1.2-1.2-0.8
Bone: trabecular thickness0.81.01.61.31.20.80.70.81.01.01.11.21.20.80.81.01.0
Bone: trabecular tissue density0.50.72.5-0.7-0.30.1-0.81.5-1.2-0.1-1.3-0.3-0.3-0.31.60.40.8
Water consumed over 24 hours0.10.10.80.10.1-0.20.1-0.90.20.3-0.2-0.1-0.10.1-0.5-0.4-0.5
Number of responses in last shaping day0.91.02.4-0.9-0.9-1.5-1.2-0.0-1.3-0.7-1.6-1.1-1.2-0.8-0.1-0.9-0.4