Hub : Genes

Arrdc4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Arrdc4	0.05	0.03	1.9e-03	0.03	0.04	0.03	0.03	1.1e-02	4.1e-03	1.1e-02	8.4e-03
2	Adipose	mRNA stability	Arrdc4	0.02	0.01	1.2e-03	0.02	0.02	0.02	0.02	1.3e-03	2.1e-03	5.8e-03	2.7e-03
3	Adipose	gene expression	Arrdc4	0.1	0.05	5.6e-17	0.15	0.14	0.15	0.16	2.7e-16	1.2e-15	2.8e-16	5.8e-17
4	Liver	gene expression	Arrdc4	0.02	0.02	7.9e-03	0.02	0.02	0.02	0.02	6.1e-03	6.1e-03	4.4e-03	4.6e-03
5	NAcc	gene expression	Arrdc4	0.04	0.03	3.9e-06	0.04	0.04	0.03	0.04	4.2e-07	1.5e-06	7.9e-06	6.8e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.0	0.0	0.1	0.1	0.1	0.1	-0.0	0.3
Area under the delay curve	0.0	0.0	0.0	0.2	0.2	-0.1	0.1	0.2
BMI with tail	6.4	22.1	24.0	4.9	4.9	4.8	-4.4	4.5
BMI without tail	5.6	17.2	18.6	4.2	4.3	4.3	-4.3	3.6
Body weight	7.6	33.4	37.7	6.1	5.8	5.8	-5.8	5.2
Weight adjusted by age	0.1	0.1	0.3	0.3	0.1	0.3	-0.6	0.2
Bone surface	0.4	0.8	1.1	-1.0	-1.0	-0.8	0.6	-1.0
Bone volume	0.0	0.1	0.1	-0.4	-0.4	-0.2	-0.0	-0.2
Breakpoint value in progressive ratio session	0.0	0.1	0.2	-0.2	-0.1	-0.2	0.2	-0.4
Number of licking bursts	0.1	0.1	0.3	0.3	0.1	0.4	-0.6	0.2
Context. condit. distance diff. score	0.2	0.2	0.3	-0.6	-0.5	-0.5	0.4	-0.5
Locomotion velocity, session 1	0.2	0.2	0.4	-0.3	-0.4	-0.4	0.4	-0.7
Locomotion distance, session 1	0.1	0.1	0.2	-0.0	-0.3	-0.3	0.3	-0.5
Locomotion velocity, session 2	0.1	0.1	0.3	0.5	0.5	0.2	0.1	0.3
Locomotion distance, session 2	0.0	0.0	0.1	-0.0	-0.0	-0.2	0.2	-0.3
Locomotion velocity, session 3	0.2	0.2	0.2	0.5	0.4	0.5	-0.5	0.4
Locomotion distance, session 3	0.1	0.1	0.2	0.3	0.5	0.3	-0.3	0.4
Stereotopy head waving bouts, day 3	0.9	1.1	1.2	-1.1	-1.0	-1.1	1.0	-1.0
Stereotopy head waving duration, day 3	0.1	0.1	0.1	0.2	0.2	0.3	-0.3	0.3
Locomotion velocity, session 7	1.4	1.6	1.9	1.4	1.2	1.2	-1.3	1.1
Locomotion distance, session 7	0.6	0.8	1.7	0.7	0.8	1.0	-1.3	0.6
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.0	0.1	0.0	-0.1	-0.2
Stereotopy head waving duration, day 7	0.0	0.0	0.0	0.1	0.0	0.0	-0.1	-0.1
Locomotion velocity, session 8	0.0	0.1	0.1	0.2	0.1	0.2	-0.3	-0.2
Locomotion distance, session 8	0.1	0.2	0.2	-0.4	-0.4	-0.4	0.3	-0.5
Degree of sensitization distance	0.4	0.4	1.1	0.4	0.4	0.8	-1.0	0.3
Degree of sensitization stereotypy	0.0	0.0	0.0	0.1	0.1	0.1	-0.2	-0.1
Conditioned locomotion	0.4	0.5	0.7	-0.6	-0.8	-0.8	0.7	-0.4
Cocaine response after cond. corrected	0.1	0.1	0.3	0.0	0.1	0.3	-0.5	-0.2
Cocaine response after cond. not corrected	0.1	0.1	0.4	0.1	0.1	0.4	-0.7	-0.4
Cocaine response before conditioning	0.7	0.8	1.6	-0.7	-0.8	-0.8	0.7	-1.3
Saline control response	1.5	2.0	2.2	-1.3	-1.5	-1.5	1.4	-1.3
Bone: connectivity density	0.1	0.2	0.3	-0.4	-0.5	-0.4	0.5	-0.5
Bone: cortical apparent density	0.2	0.2	0.6	0.4	0.5	0.1	0.2	0.8
Bone: cortical area	0.0	0.1	0.1	-0.3	-0.4	-0.1	-0.0	-0.2
Bone: cortical porosity	0.1	0.1	0.2	0.3	0.5	0.2	-0.0	0.4
Bone: cortical porosity	0.1	0.1	0.1	0.2	0.3	0.2	0.0	0.3
Bone: cortical thickness	0.0	0.0	0.1	0.0	0.2	0.0	0.1	0.4
Bone: cortical thickness	0.1	0.1	0.2	-0.1	-0.1	-0.3	0.5	-0.0
Bone: cortical tissue density	0.2	0.2	0.6	0.4	0.6	0.1	0.3	0.8
Condit. Reinf. active minus inactive responses	6.9	7.7	8.6	2.9	2.8	2.7	-2.6	2.8
Condit. Reinf. active-inactive response ratio	2.7	2.9	3.5	1.9	1.7	1.6	-1.4	1.8
Condit. Reinf. active responses	4.4	5.5	5.9	2.4	2.3	2.4	-2.3	2.3
Condit. Reinf. inactive responses	0.0	0.1	0.2	0.1	0.1	0.3	-0.4	0.1
Incentive salience index mean	3.7	4.5	5.1	2.3	2.1	2.1	-2.1	2.1
Condit. Reinf. lever presses	1.3	1.9	2.1	1.4	1.3	1.4	-1.4	1.2
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	-0.6	-0.6	-0.4	0.2	-0.7
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.6	-0.7	-0.7	-0.5	0.4	-0.8
Condit. Reinf. active responses	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.1	-0.4
Condit. Reinf. inactive responses	1.0	1.3	1.7	1.2	1.1	1.3	-1.3	0.8
Condit. Reinf. lever presses	1.5	2.1	2.6	1.5	1.4	1.6	-1.6	1.3
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	-0.1	-0.2	0.0	-0.1	-0.3
Conditioned reinforcement - actives	0.1	0.1	0.3	0.4	0.6	-0.1	0.2	0.2
Conditioned reinforcement - inactives	0.2	0.3	0.4	0.7	0.6	0.5	-0.6	0.2
Conditioned locomotion	2.3	3.0	4.4	1.8	2.1	1.7	-1.6	1.4
Patch foraging indifference point 0 sec	0.6	1.1	1.4	1.2	0.9	1.0	-1.1	1.0
Patch foraging indifference point AUC	0.2	0.3	1.0	0.3	-0.3	0.4	-1.0	-0.2
Delay disc. indifference point, 0s delay	0.4	0.4	0.8	-0.5	-0.3	-0.6	0.9	-0.8
Delay disc. indifference point, 16s delay	0.3	0.3	0.6	0.5	0.5	0.5	-0.5	0.8
Delay disc. indifference point, 2s delay	0.1	0.2	0.3	0.5	0.5	0.2	-0.4	-0.2
Delay disc. indifference point, 24s delay	0.0	0.0	0.2	-0.0	-0.1	-0.2	0.4	0.1
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	0.6	0.6	0.5	-0.6	0.1
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	-0.4	-0.3	-0.6	0.6	-0.1
Indifference point function ln k	1.4	2.5	4.2	1.5	2.1	1.4	-0.8	1.8
Indifference point function log k	1.4	2.5	4.2	1.5	2.1	1.4	-0.8	1.8
Patch foraging total patch changes 0 sec	0.6	1.1	1.4	1.2	1.0	1.0	-0.9	1.0
Patch foraging total patch changes 12 sec	0.3	0.4	0.9	-0.4	-0.9	-0.6	0.4	-0.5
Patch foraging total patch changes 18 sec	0.3	0.4	0.9	-0.6	-0.9	-0.4	-0.0	-0.9
Patch foraging total patch changes 24 sec	0.7	1.3	1.5	1.2	1.1	1.1	-1.1	1.0
Patch foraging total patch changes 6 sec	1.0	1.5	2.6	1.3	0.7	1.3	-1.6	1.1
Patch foraging time to switch 0 sec	1.9	3.9	4.5	-2.1	-1.8	-2.1	2.1	-1.8
Patch foraging water rate 0 sec	0.8	1.6	2.7	1.5	1.2	1.0	-0.7	1.7
Patch foraging water rate 12 sec	0.8	1.6	2.6	1.4	1.6	1.0	-0.5	1.4
Patch foraging water rate 18 sec	2.6	4.0	5.8	2.2	2.4	1.7	-1.0	2.3
Patch foraging water rate 24 sec	1.4	2.0	3.8	1.6	1.6	1.1	-0.4	2.0
Patch foraging water rate 6 sec	0.6	0.8	2.0	0.9	1.4	0.4	0.5	1.0
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.5	-0.6	-0.3	-0.5	0.7	-0.4
Distance traveled before self-admin	0.7	1.0	1.7	0.7	1.1	1.1	-1.3	0.2
Distance traveled after self-admin	0.9	1.2	1.6	1.0	1.3	1.2	-1.3	0.4
Extensor digitorum longus weight	0.2	0.9	1.1	1.0	0.9	1.0	-1.0	0.7
Bone: elastic displacement	0.8	0.9	1.4	1.0	1.2	0.9	-0.6	0.9
Bone: elastic work	1.1	1.4	1.6	1.2	1.3	1.2	-1.0	1.2
Bone: endosteal estimation	0.8	1.7	2.7	-1.1	-1.5	-1.1	0.8	-1.6
Bone: endosteal perimeter	0.3	0.7	1.5	-0.8	-1.1	-0.5	0.0	-1.2
Epididymis fat weight	4.7	16.0	18.8	4.0	4.3	4.1	-4.0	3.5
Delta time in closed arm before/after self-admin	0.2	0.2	0.9	0.0	-0.0	0.4	-1.0	0.2
Delta time in open arm before/after self-admin	4.0	3.9	4.5	2.1	2.0	2.1	-1.8	1.9
Diff in mean of infusions in LGA sessions	0.0	0.1	0.1	-0.1	-0.1	0.2	-0.3	-0.3
Delay discount exponential model param	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	-0.0
Extinction: sum of active levers before priming	2.0	2.3	3.1	1.5	1.4	1.5	-1.7	1.3
Active lever presses in extinction session 6	1.4	1.4	2.0	1.2	1.1	1.2	-1.4	1.0
Bone: final force	0.7	1.1	1.3	-1.0	-1.1	-1.1	1.1	-1.1
Bone: final moment	0.3	0.5	0.6	-0.6	-0.7	-0.8	0.8	-0.8
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.3	0.4	0.4	-0.4	0.1
Glucose	0.5	0.7	0.9	0.8	0.9	0.9	-0.9	0.6
Heart weight	0.4	0.6	1.0	0.9	0.7	0.6	-0.4	1.0
Delay discount hyperbolic model param	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.1	0.0
Intermittent access intake day 1-15 change	2.0	4.1	6.5	-2.0	-2.1	-1.9	1.5	-2.6
Intermittent access intake escalation	2.2	4.5	5.8	-2.0	-2.2	-2.1	1.9	-2.4
Intermittent access intake escalation 2	1.9	2.2	3.2	-1.4	-1.4	-1.4	1.3	-1.8
Intermitt. access day 1 inactive lever presses	0.6	2.3	4.2	1.6	2.1	1.4	-1.0	1.3
Intermitt. access day 15 inactive lever presses	0.2	0.3	0.5	0.5	0.7	0.5	-0.6	0.5
Intermitt. access escalation Index	0.1	0.2	0.3	-0.2	-0.4	-0.5	0.6	0.2
Intermittent access day 1 total infusions	0.5	0.7	1.7	0.8	1.1	0.3	0.4	1.3
Intermittent access day 15 total infusions	0.7	1.0	2.5	-0.7	-0.7	-1.2	1.6	-0.3
Intermittent access terminal intake (last 3 days)	0.4	0.5	1.4	-0.5	-0.3	-0.9	1.2	-0.2
Intermittent access total infusions	0.3	0.4	1.1	0.1	0.5	-0.4	1.0	0.5
Intermittent access day 1 locomotion	2.8	3.6	4.6	2.0	1.9	1.8	-1.5	2.1
Intermittent access day 15 total locomotion	0.1	0.1	0.3	0.4	-0.0	0.3	-0.4	0.6
Intermittent access total locomotion	0.5	0.6	1.1	0.9	0.8	0.7	-0.4	1.1
Intermittent access standard deviation	0.3	0.6	1.8	-0.6	-0.5	-0.6	0.6	-1.3
Left kidney weight	0.2	0.8	1.1	1.1	1.0	0.8	-0.9	0.6
Right kidney weight	0.1	0.4	0.8	0.9	0.9	0.5	-0.5	0.3
Cocaine induced anxiety	0.3	0.4	0.6	0.6	0.5	0.7	-0.6	0.8
Post-drug Anxiety	1.5	1.6	2.1	1.2	1.1	1.4	-1.3	1.5
Baseline Anxiety	0.6	0.7	1.0	0.7	0.6	0.8	-1.0	1.0
Tail length	1.6	6.1	7.6	2.7	2.5	2.5	-2.8	1.8
Length with tail	2.3	10.1	11.8	3.4	3.2	3.2	-3.4	2.6
Length without tail	1.4	4.4	5.4	2.3	2.0	2.1	-2.2	1.9
Times rat made contact with spout	0.5	0.6	0.9	0.7	0.7	0.8	-0.9	0.6
Lifetime Intake	0.4	0.5	0.8	0.4	0.8	-0.2	0.9	0.9
Liver weight, left	0.2	0.3	0.6	0.5	0.3	0.7	-0.8	0.5
Liver weight, right	1.9	3.4	4.1	1.8	1.6	1.9	-2.0	1.9
Locomotor activity	0.1	0.2	0.4	0.2	0.4	0.5	-0.6	0.1
Locomotor testing distance	0.2	0.3	0.6	0.5	0.8	0.6	-0.6	0.4
Locomotor testing rearing	0.0	0.0	0.1	-0.3	-0.1	-0.2	0.2	-0.1
Locomotion in novel chamber	1.3	1.7	2.6	-1.2	-1.0	-1.4	1.6	-1.3
Locomotion in novel chamber post-restriction	1.1	1.7	2.3	-1.4	-1.5	-1.2	1.2	-1.2
Fecal boli incidents, locomotor time 1	3.0	4.3	6.3	-2.3	-2.1	-1.8	1.4	-2.5
Change in fecal boli incidents, locomotor task	0.6	0.6	1.4	0.8	0.9	0.2	-0.1	1.2
Time >=10cm from walls, locomotor time 1	1.0	1.1	1.5	1.0	1.2	1.0	-1.2	0.6
Bouts of movement, locomotor time 1	1.2	1.4	1.7	-1.2	-1.1	-1.2	0.9	-1.3
Total resting periods, locomotor time 1	1.2	1.4	1.9	-1.2	-1.2	-1.2	0.8	-1.4
Rest time, locomotor task time 1	1.5	1.8	2.4	-1.4	-1.5	-1.5	1.3	-1.0
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.3	0.1	0.2	-0.1	0.2
Vertical activity count, locomotor time 1	0.1	0.2	0.4	-0.3	-0.5	-0.3	0.7	-0.1
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.5	-0.0	-0.2	-0.7	0.4	0.0
Bouts of movement, locomotor time 2	0.1	0.2	0.4	0.3	0.4	0.5	-0.6	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.4	0.2	0.2	0.4	-0.6	0.1
Rest time, locomotor task time 2	0.2	0.2	0.4	-0.6	-0.5	-0.4	0.3	-0.5
Distance moved, locomotor task time 2	0.2	0.3	0.5	-0.1	-0.5	-0.6	0.7	-0.4
Vertical activity count, locomotor time 2	1.1	1.5	1.7	-1.0	-1.3	-1.3	1.2	-1.3
Light reinforcement 1	0.1	0.2	0.5	0.5	0.3	0.6	-0.7	-0.0
Light reinforcement 2	0.2	0.2	0.3	-0.4	-0.5	-0.5	0.5	-0.5
Bone: marrow area	0.8	1.8	2.8	-1.2	-1.6	-1.2	0.9	-1.7
Bone: maximum diameter	0.1	0.1	0.3	-0.4	-0.5	-0.2	-0.1	-0.5
Bone: maximum force	0.4	0.7	0.8	-0.8	-0.9	-0.9	0.8	-0.8
Bone: maximum moment	0.1	0.2	0.2	-0.4	-0.5	-0.5	0.4	-0.4
Mean time between licks in bursts	3.4	8.4	8.9	-3.0	-2.9	-3.0	3.0	-2.7
Mean num. licks in bursts	0.0	0.0	0.1	0.0	0.2	-0.1	0.2	0.3
Cd content in liver	0.5	0.6	1.2	-0.9	-0.6	-0.6	0.4	-1.1
Co content in liver	0.6	0.7	1.2	-1.1	-0.9	-0.7	0.4	-0.9
Cu content in liver	0.0	0.0	0.1	0.1	0.1	0.1	-0.1	0.3
Fe content in liver	2.0	2.4	3.2	1.6	1.2	1.6	-1.5	1.8
K content in liver	0.4	0.4	0.7	-0.7	-0.5	-0.5	0.6	-0.8
Mg content in liver	0.1	0.2	0.4	-0.5	-0.2	-0.1	0.0	-0.7
Mn content in liver	0.0	0.0	0.0	-0.2	0.2	-0.1	0.2	-0.2
Na content in liver	0.3	0.3	0.4	0.6	-0.0	0.5	-0.7	0.6
Rb content in liver	0.5	0.6	1.0	-0.8	-1.0	-0.7	0.5	-0.6
Se content in liver	2.0	2.4	3.7	-1.4	-1.4	-1.6	1.9	-1.2
Sr content in liver	0.1	0.1	0.3	-0.1	0.6	0.3	-0.1	-0.2
Zn content in liver	0.2	0.3	0.6	-0.6	-0.5	-0.3	0.1	-0.8
Bone: minimum diameter	0.4	0.7	1.4	-0.8	-1.2	-0.7	0.4	-1.0
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.0	0.2
Time in novel zone, hab. session 1	0.0	0.0	0.1	-0.1	0.1	-0.1	0.2	-0.4
Total zone transitions, hab. session 1	1.3	1.8	2.1	1.4	1.4	1.3	-1.2	1.3
Total locomotion distance, hab. session 1	0.6	0.8	1.1	-0.7	-0.8	-1.0	0.9	-1.0
Locomotion velocity, hab. session 1	0.3	0.4	0.7	-0.5	-0.6	-0.7	0.6	-0.8
Time in familiar zone, hab. session 2	1.4	1.4	2.0	-1.3	-1.4	-1.0	0.7	-1.4
Time in novel zone, hab. session 2	1.8	1.9	2.3	1.4	1.5	1.3	-1.0	1.5
Total zone transitions, hab. session 2	1.9	2.4	2.8	1.7	1.6	1.5	-1.5	1.5
Total locomotion distance, hab. session 2	0.2	0.2	0.4	-0.4	-0.4	-0.5	0.4	-0.6
Locomotion velocity, hab. session 2	0.2	0.2	0.3	-0.3	-0.3	-0.6	0.6	-0.5
Novel to familiar place preference ratio	0.6	0.7	0.9	-0.9	-0.8	-0.7	0.7	-0.9
Novelty place preference	0.9	0.9	1.2	-1.0	-0.9	-0.9	0.8	-1.1
Time in novel zone, NPP test	0.4	0.4	0.7	-0.8	-0.6	-0.5	0.5	-0.8
Total zone transitions, NPP test	1.0	1.4	1.7	1.3	1.3	1.1	-1.0	1.2
Total locomotion distance, NPP test	1.5	2.0	2.2	-1.3	-1.4	-1.5	1.4	-1.4
Locomotion velocity, NPP test	1.6	2.3	2.7	-1.4	-1.5	-1.6	1.6	-1.5
Intraocular pressure	2.1	3.1	4.1	1.5	1.6	1.8	-1.7	2.0
Delta distance traveled before/after self-admin	0.2	0.3	0.6	0.8	0.3	0.3	-0.3	0.6
Delta ambulatory time before/after self-admin	0.3	0.4	0.8	0.9	0.5	0.5	-0.5	0.7
Parametrial fat weight	6.1	14.2	15.1	3.9	3.6	3.9	-3.8	3.7
Pavlov. Cond. lever latency	0.2	0.2	0.3	-0.5	-0.5	-0.5	0.6	-0.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.1	0.2	0.2	-0.2	0.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.2	-0.5
Pavlov. Cond. index score	0.0	0.0	0.0	0.0	0.1	0.1	-0.1	0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.0	-0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.3	0.4	0.4	-0.5	0.1
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.1	-0.1	0.0	-0.1	-0.3
Pavlov. Cond. intertrial magazine entries	2.4	2.9	3.0	-1.7	-1.7	-1.7	1.7	-1.7
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.1	-0.0	-0.1	0.1	0.1
Pavlov. Cond. response bias	0.4	0.5	0.7	0.7	0.8	0.6	-0.5	0.8
Pavlov. Cond. lever latency	1.3	1.8	2.4	-1.3	-1.2	-1.4	1.5	-1.2
Pavlov. Cond. magazine entry latency	1.0	1.2	1.7	1.2	0.9	1.2	-1.3	0.9
Pavlov. Cond. change in total contacts	2.0	3.3	4.0	1.7	1.7	1.9	-2.0	1.6
Pavlov. Cond. index score	1.9	2.6	3.7	1.5	1.5	1.8	-1.9	1.3
Pavlov. Cond. latency score	1.5	2.0	2.8	1.4	1.3	1.6	-1.7	1.2
Pavlov. Cond. lever contacts	1.3	1.8	2.3	1.3	1.3	1.5	-1.5	1.2
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	-0.5	-0.5	-0.7	0.9	-0.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.1	0.3	0.2	-0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.1	3.3	1.3	1.3	1.6	-1.8	1.1
Pavlov. Cond. response bias	1.5	2.0	2.8	1.3	1.3	1.6	-1.7	1.2
Time in closed arm before self-admin	0.1	0.2	0.3	-0.4	-0.5	-0.3	0.1	-0.5
Time in closed arm after self-admin	0.1	0.1	0.2	-0.4	-0.5	-0.2	-0.4	-0.0
Time in open arm before self-admin	0.1	0.1	0.2	-0.4	-0.1	-0.3	0.4	-0.4
Time in open arm after self-admin	0.3	0.3	0.5	0.7	0.7	0.6	-0.4	0.3
Bone: periosteal estimation	0.5	1.1	1.7	-1.0	-1.3	-0.9	0.7	-1.2
Bone: periosteal perimeter	0.3	0.4	0.9	-0.7	-0.9	-0.5	0.2	-0.8
Bone: post-yield work	0.1	0.1	0.3	0.4	0.1	0.4	-0.5	0.3
Progressive ratio test 1 active lever presses	1.9	2.4	3.2	1.7	1.8	1.3	-0.9	1.8
Progressive ratio test 1 breakpoint	2.2	2.7	3.5	1.8	1.9	1.5	-1.0	1.9
Progressive ratio test 1 inactive lever presses	0.7	1.0	1.8	1.2	1.4	0.7	-0.2	1.2
Progressive ratio test 2 active lever presses	0.6	0.7	2.3	0.8	0.7	0.2	0.3	1.5
Progressive ratio test 2 breakpoint	0.5	0.6	2.0	0.7	0.6	0.1	0.4	1.4
Progressive ratio test 2 inactive lever presses	1.6	2.6	3.6	1.6	1.9	1.4	-1.2	1.8
Incentive Sensitization - Responses	0.3	0.4	1.1	-0.5	-0.5	-0.8	1.0	-0.0
Incentive Sensitization - Breakpoint	0.5	0.6	1.4	-0.6	-0.6	-1.0	1.2	-0.2
Sum of active levers in priming session hrs 5-6	1.3	1.2	2.7	0.8	1.0	1.3	-1.6	0.4
Progressive ratio	1.0	1.5	2.1	1.2	1.5	1.3	-1.2	0.9
Food seeking constrained by brief footshock	2.4	2.9	4.5	1.6	1.5	1.8	-2.1	1.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.4	-0.5	-0.2	-0.1	-0.5
Retroperitoneal fat weight	7.7	32.9	34.7	5.7	5.7	5.9	-5.9	5.5
Reaction time number correct	3.2	6.2	7.0	2.6	2.5	2.6	-2.5	2.2
Reaction time mean minus median	0.4	0.9	1.7	-1.2	-0.9	-0.7	0.5	-1.3
Reaction time mean minus median AUC	0.3	0.7	1.4	-1.0	-0.8	-0.6	0.4	-1.2
Reaction time num false alarms	0.6	0.9	1.6	-1.2	-1.3	-0.8	0.3	-0.9
Reaction time num false alarms AUC	0.2	0.3	0.6	-0.8	-0.8	-0.3	-0.1	-0.6
Reaction time trials correct on left	3.2	6.2	7.0	2.6	2.5	2.6	-2.5	2.2
Reaction time trials on left	3.1	5.9	6.6	2.5	2.4	2.6	-2.5	2.1
Reaction time mean	3.6	5.7	6.2	-2.5	-2.4	-2.4	2.3	-2.4
Reaction time mean AUC	2.8	4.5	4.9	-2.2	-2.1	-2.2	2.0	-2.2
Median of all reaction times	4.5	6.3	6.9	-2.6	-2.5	-2.6	2.5	-2.4
Reaction time omissions	0.8	1.2	1.6	-1.3	-0.8	-1.0	1.2	-1.1
Reaction time false alarm rate	1.7	2.3	3.1	-1.8	-1.7	-1.5	1.1	-1.4
Reaction time premature initiation rate	0.5	0.7	1.1	-0.7	-0.6	-0.9	1.0	-0.9
Reaction time premature initiations	0.1	0.2	0.3	0.4	0.5	0.4	-0.3	0.1
Std. dev. reaction times	1.2	2.2	2.8	-1.7	-1.5	-1.4	1.2	-1.6
Reaction time trials completed	3.1	5.9	6.6	2.5	2.4	2.6	-2.5	2.1
Reaction time trials AUC	3.0	5.8	6.6	2.5	2.4	2.6	-2.5	2.1
Run reversals in cocaine runway, females	0.2	0.2	0.5	0.0	0.5	0.4	-0.4	-0.7
Run reversals in cocaine runway, males	4.8	4.8	5.5	2.1	2.2	2.4	-2.3	2.0
Latency to leave start box in cocaine runway	1.2	1.3	1.6	-1.2	-1.1	-1.2	1.3	-1.0
Latency to leave start box in cocaine runway, F	1.4	1.6	1.9	-1.4	-1.3	-1.2	1.3	-1.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.1	-0.2	-0.4	0.4	0.0
Std. dev. time between licks in bursts	2.6	3.6	4.4	-1.9	-2.1	-2.0	1.8	-1.7
Total sessions with >9 infusions	0.1	0.1	0.4	-0.0	0.2	-0.3	0.6	0.2
Short access day 1 total inactive lever presses	0.1	0.1	0.3	0.4	0.6	0.1	0.3	0.2
Short access day 10 total inactive lever presses	1.3	3.2	6.5	1.9	1.9	1.4	-0.8	2.6
Short access day 1 total infusions	0.4	0.6	1.2	0.8	1.1	0.5	-0.1	0.9
Short access day 10 total infusions	0.4	0.5	1.7	-0.2	0.3	-0.7	1.3	0.2
Short access total infusions	0.5	0.6	1.3	0.8	1.1	0.3	0.2	1.0
Short access day 1 locomotion	1.0	1.2	1.7	1.2	1.0	1.1	-1.3	0.7
Short access day 10 total locomotion	0.3	0.6	1.0	0.7	1.0	0.6	-0.6	0.7
Short access total locomotion	1.8	2.1	2.5	1.5	1.6	1.5	-1.4	1.4
One hour access (0.3 mA shock)	0.3	0.3	0.9	-0.3	-0.0	-0.7	1.0	-0.4
Compulsive drug intake	1.8	2.1	4.7	1.2	1.4	1.6	-2.2	0.4
One hour access (shock baseline)	1.1	1.6	3.6	-1.0	-1.0	-1.5	1.9	-0.6
Social response proportion	0.1	0.1	0.3	-0.1	0.3	-0.3	0.6	-0.2
Social responses	0.5	0.6	0.8	0.8	0.6	0.8	-0.9	0.8
Social time	0.4	0.5	0.8	0.6	0.7	0.9	-0.9	0.6
Soleus weight	1.3	3.8	4.5	1.9	1.9	2.1	-2.1	1.8
Bone: stiffness	1.1	1.8	2.2	-1.4	-1.5	-1.4	1.2	-1.1
Tibialis anterior weight	0.0	0.1	0.2	0.2	0.5	0.4	-0.4	0.1
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.8	0.1	0.2	-0.4	0.9	0.4
Time to tail flick, vehicle, after self-admin	4.1	5.5	7.8	2.5	2.4	2.2	-1.7	2.8
Time to tail flick, test, before self-admin	0.7	0.8	1.4	-0.7	-0.7	-0.9	1.2	-0.8
Time to tail flick, test, after self-admin	0.4	0.4	0.7	0.7	0.8	0.5	-0.4	0.5
Delta time to tail flick, vehicle, before/after SA	3.0	2.9	3.6	1.6	1.4	1.8	-1.9	1.7
Delta time to tail flick, test, before/after SA	0.4	0.5	0.5	0.7	0.7	0.6	-0.7	0.6
Tibia length	0.9	2.4	3.8	2.0	1.5	1.4	-1.4	1.5
Ambulatory time before self-admin	0.7	1.1	1.6	0.9	1.3	1.2	-1.3	0.5
Ambulatory time after self-admin	1.8	2.2	2.8	1.5	1.7	1.5	-1.5	1.0
Bone: tissue strength	0.4	0.4	0.6	0.7	0.8	0.6	-0.4	0.8
Total heroin consumption	1.0	1.1	1.5	0.9	1.2	1.0	-1.2	0.9
Bone: trabecular number	0.2	0.3	0.4	-0.6	-0.5	-0.5	0.4	-0.6
Bone: trabecular spacing	0.3	0.3	0.7	0.8	0.5	0.5	-0.4	0.6
Bone: trabecular thickness	0.8	1.0	1.2	0.9	0.9	1.0	-1.1	1.1
Bone: trabecular tissue density	0.2	0.3	0.4	-0.7	-0.6	-0.4	0.2	-0.6
Water consumed over 24 hours	0.8	1.1	1.5	1.0	1.2	1.0	-1.0	0.9
Number of responses in last shaping day	0.9	0.9	1.4	1.1	0.9	0.8	-0.7	1.2