Hub : Genes

Arid3a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Arid3a	0.04	0.03	4.4e-04	0.03	0.02	0.02	0.02	4.1e-04	9.2e-04	5.9e-03	1.2e-03
2	Adipose	gene expression	Arid3a	0.19	0.11	9.3e-12	0.05	0.09	0.09	0.09	1.7e-06	3.8e-10	1.3e-10	3.7e-10
3	NAcc	gene expression	Arid3a	0.02	0.01	7.5e-03	0.02	0.01	0.01	0.01	3.1e-03	7.9e-03	7.2e-03	5.8e-03
4	Brain	alternative TSS	XM_006240905.4	0.03	0.02	4.3e-03	0.01	0	0	0.01	1.8e-02	1.1e-01	2.9e-01	9.0e-02
5	LHb	isoform ratio	NM_001108066.2	0.26	0.17	5.5e-03	0.05	0.08	0.11	0.08	2.5e-02	7.5e-03	1.5e-03	7.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	1.4	2.3	5.4	-1.0	-1.9	-0.9	-0.6	2.3
Area under the delay curve	1.8	1.9	2.7	1.6	1.1	-1.6	-1.6	0.6
BMI with tail	4.8	15.6	23.1	4.8	3.6	-4.4	-4.6	1.2
BMI without tail	2.6	5.3	9.0	3.0	3.0	-2.0	-2.0	-0.7
Body weight	0.9	4.0	6.1	2.5	1.9	-2.2	-2.3	0.5
Weight adjusted by age	1.0	1.1	2.6	1.2	1.6	-0.5	-0.4	-1.1
Bone surface	2.6	4.6	9.7	-2.0	-3.1	-0.4	-0.3	3.0
Bone volume	2.6	4.3	9.0	-1.9	-3.0	-0.6	-0.3	3.0
Breakpoint value in progressive ratio session	4.0	4.4	7.0	-2.1	-1.1	2.7	2.7	-1.5
Number of licking bursts	0.6	0.6	1.4	0.7	1.2	0.2	0.0	-1.2
Context. condit. distance diff. score	0.3	0.3	0.6	0.8	0.8	-0.4	-0.6	-0.2
Locomotion velocity, session 1	1.1	1.1	2.6	-1.3	-1.6	0.5	0.5	1.0
Locomotion distance, session 1	2.1	2.7	5.7	-1.4	-2.4	-0.2	-0.1	2.4
Locomotion velocity, session 2	4.8	5.6	11.0	-3.0	-3.3	1.8	1.7	1.4
Locomotion distance, session 2	3.5	4.9	11.1	-2.6	-3.3	0.8	1.0	2.2
Locomotion velocity, session 3	4.6	5.4	8.2	-2.5	-1.5	2.9	2.9	-1.4
Locomotion distance, session 3	0.1	0.1	0.2	0.3	0.5	0.1	0.0	-0.5
Stereotopy head waving bouts, day 3	4.2	4.9	7.5	-2.7	-2.4	2.4	2.3	-0.0
Stereotopy head waving duration, day 3	4.7	5.6	8.1	-2.8	-2.3	2.8	2.6	-0.5
Locomotion velocity, session 7	0.3	0.3	0.6	-0.4	0.0	0.7	0.7	-0.7
Locomotion distance, session 7	0.7	0.9	2.1	1.0	1.4	-0.2	-0.2	-1.1
Stereotopy head waving bouts, day 7	0.5	0.6	1.4	-0.6	-1.1	-0.1	-0.2	1.2
Stereotopy head waving duration, day 7	0.8	1.0	2.3	-1.0	-1.5	0.2	0.2	1.2
Locomotion velocity, session 8	1.8	2.1	4.9	-1.6	-2.2	0.4	0.4	1.7
Locomotion distance, session 8	0.4	0.6	1.3	-0.8	-1.1	0.3	0.2	0.9
Degree of sensitization distance	0.3	0.3	0.5	0.6	0.4	-0.7	-0.7	0.3
Degree of sensitization stereotypy	1.5	1.6	2.6	1.0	0.2	-1.6	-1.6	1.3
Conditioned locomotion	1.8	2.1	4.2	1.9	2.1	-1.0	-1.0	-0.9
Cocaine response after cond. corrected	5.8	6.5	11.5	3.4	3.4	-2.0	-2.1	-1.0
Cocaine response after cond. not corrected	6.3	6.9	12.4	3.4	3.5	-2.1	-2.2	-1.1
Cocaine response before conditioning	0.4	0.4	0.7	-0.8	-0.7	0.6	0.7	-0.1
Saline control response	0.0	0.0	0.1	0.3	0.3	-0.1	-0.2	-0.1
Bone: connectivity density	0.9	1.4	3.6	-0.3	-1.2	-1.1	-0.9	1.9
Bone: cortical apparent density	0.5	0.6	1.1	0.9	0.6	-1.0	-0.9	0.3
Bone: cortical area	0.6	0.9	1.5	0.5	-0.1	-1.2	-1.2	1.2
Bone: cortical porosity	0.6	0.7	1.4	-1.0	-1.2	0.5	0.5	0.6
Bone: cortical porosity	0.8	0.8	1.9	-0.7	-1.3	-0.2	-0.3	1.4
Bone: cortical thickness	0.9	1.4	2.5	1.0	0.4	-1.6	-1.5	1.1
Bone: cortical thickness	0.6	0.7	1.6	0.6	1.1	0.2	0.2	-1.2
Bone: cortical tissue density	0.3	0.4	0.7	0.7	0.5	-0.8	-0.7	0.2
Condit. Reinf. active minus inactive responses	3.4	3.8	6.3	-2.2	-1.6	2.5	2.2	-0.8
Condit. Reinf. active-inactive response ratio	1.9	2.0	3.9	-1.1	-0.3	2.0	1.7	-1.4
Condit. Reinf. active responses	3.6	4.4	7.0	-2.7	-2.5	2.1	2.0	0.4
Condit. Reinf. inactive responses	1.9	2.3	5.3	-1.8	-2.3	0.6	0.7	1.5
Incentive salience index mean	2.2	2.7	4.2	-2.0	-2.0	1.7	1.5	0.4
Condit. Reinf. lever presses	1.6	2.2	5.1	-1.1	-2.1	-0.3	-0.3	2.3
Condit. Reinf. active minus inactive responses	1.7	2.2	3.5	-1.1	-0.1	1.8	1.9	-1.7
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.7	0.3	0.9	0.5	0.5	-1.3
Condit. Reinf. active responses	1.4	1.9	3.3	-1.3	-0.4	1.7	1.8	-1.4
Condit. Reinf. inactive responses	0.7	0.8	1.3	-1.0	-0.5	1.1	1.2	-0.7
Condit. Reinf. lever presses	1.7	2.3	3.7	-1.2	-0.3	1.9	1.9	-1.6
Condit. Reinf. lever reinforcers received	1.2	1.7	2.7	-0.9	0.0	1.5	1.6	-1.6
Conditioned reinforcement - actives	1.4	1.4	2.0	-1.4	-0.9	1.4	1.4	-0.5
Conditioned reinforcement - inactives	0.6	0.7	1.4	1.1	1.2	-0.5	-0.5	-0.6
Conditioned locomotion	4.8	5.8	8.3	-2.8	-1.9	2.9	2.9	-1.1
Patch foraging indifference point 0 sec	0.1	0.2	0.4	0.3	-0.0	-0.6	-0.6	0.6
Patch foraging indifference point AUC	0.5	0.6	1.1	-0.8	-0.5	1.1	0.9	-0.5
Delay disc. indifference point, 0s delay	6.0	6.6	10.1	1.7	-0.0	-3.2	-3.2	3.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.3	0.3	-0.3	-0.3	0.0
Delay disc. indifference point, 2s delay	4.2	4.7	7.4	2.1	1.0	-2.7	-2.7	1.8
Delay disc. indifference point, 24s delay	0.7	0.7	1.2	1.1	1.0	-0.8	-0.8	-0.1
Delay disc. indifference point, 4s delay	0.6	0.7	1.1	0.8	0.4	-1.0	-1.0	0.7
Delay disc. indifference point, 8s delay	1.5	1.6	2.6	1.6	1.6	-1.1	-1.1	-0.3
Indifference point function ln k	0.3	0.4	0.7	0.8	0.8	-0.6	-0.5	-0.3
Indifference point function log k	0.3	0.4	0.7	0.8	0.8	-0.6	-0.5	-0.3
Patch foraging total patch changes 0 sec	0.1	0.1	0.3	0.3	0.1	-0.4	-0.5	0.4
Patch foraging total patch changes 12 sec	0.4	0.5	0.9	0.9	1.0	-0.4	-0.6	-0.3
Patch foraging total patch changes 18 sec	0.8	1.1	1.8	-1.2	-0.8	1.3	1.1	-0.4
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	-0.4	-0.4	0.2	0.2	0.2
Patch foraging total patch changes 6 sec	0.2	0.3	0.5	-0.7	-0.7	0.6	0.4	0.2
Patch foraging time to switch 0 sec	1.6	2.4	6.1	0.2	-1.0	-1.6	-1.6	2.5
Patch foraging water rate 0 sec	1.2	2.0	4.6	1.1	2.0	0.4	0.3	-2.1
Patch foraging water rate 12 sec	2.0	3.1	7.0	2.2	2.6	-0.9	-0.9	-1.6
Patch foraging water rate 18 sec	3.0	4.0	10.2	1.3	2.6	0.8	0.8	-3.2
Patch foraging water rate 24 sec	2.9	4.1	9.1	2.0	3.0	-0.1	-0.0	-2.7
Patch foraging water rate 6 sec	1.3	1.9	5.3	0.5	1.5	0.8	0.9	-2.3
Seeking ratio, delayed vs. immediate footshock	3.2	3.6	5.8	-2.4	-2.0	2.0	2.1	-0.3
Distance traveled before self-admin	0.5	0.5	0.8	0.5	-0.0	-0.9	-0.9	0.9
Distance traveled after self-admin	0.4	0.5	0.8	-0.9	-0.9	0.6	0.6	0.2
Extensor digitorum longus weight	3.8	14.9	24.1	4.9	4.2	-4.0	-4.1	0.1
Bone: elastic displacement	0.2	0.2	0.4	-0.6	-0.6	0.4	0.5	0.0
Bone: elastic work	0.2	0.2	0.4	0.5	0.2	-0.6	-0.7	0.4
Bone: endosteal estimation	0.1	0.3	0.5	0.4	0.1	-0.5	-0.7	0.6
Bone: endosteal perimeter	0.2	0.5	0.9	-0.9	-1.0	0.5	0.5	0.4
Epididymis fat weight	0.2	0.5	0.9	-0.6	-0.2	0.9	0.9	-0.7
Delta time in closed arm before/after self-admin	2.7	2.7	6.1	1.8	2.5	-0.4	-0.4	-1.9
Delta time in open arm before/after self-admin	0.9	0.8	1.4	0.8	0.2	-1.2	-1.2	0.9
Diff in mean of infusions in LGA sessions	1.6	1.7	2.4	-1.5	-1.1	1.6	1.6	-0.5
Delay discount exponential model param	1.7	1.8	2.5	-1.6	-1.2	1.6	1.6	-0.5
Extinction: sum of active levers before priming	1.0	1.0	1.5	-0.6	0.0	1.2	1.2	-1.2
Active lever presses in extinction session 6	1.8	1.8	2.7	-1.6	-1.3	1.5	1.5	-0.2
Bone: final force	1.1	1.8	3.0	1.2	0.4	-1.7	-1.7	1.2
Bone: final moment	0.9	1.4	2.4	1.0	0.4	-1.5	-1.5	1.1
Food consumed during 24 hour testing period	0.5	0.7	1.1	1.1	1.0	-0.8	-0.8	-0.1
Glucose	1.2	1.8	2.6	1.6	1.2	-1.6	-1.5	0.3
Heart weight	0.4	0.5	1.2	-0.2	0.4	0.8	0.9	-1.1
Delay discount hyperbolic model param	2.3	2.5	3.5	-1.8	-1.3	1.9	1.9	-0.7
Intermittent access intake day 1-15 change	4.5	4.4	6.9	-2.2	-1.2	2.6	2.6	-1.4
Intermittent access intake escalation	4.5	4.4	7.1	-1.7	-0.5	2.7	2.7	-2.1
Intermittent access intake escalation 2	5.4	5.4	8.7	-2.0	-0.6	2.9	2.9	-2.3
Intermitt. access day 1 inactive lever presses	0.4	0.5	1.3	0.3	0.8	0.5	0.5	-1.1
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.7	-0.5	-0.0	0.8	0.8	-0.8
Intermitt. access escalation Index	0.6	0.6	1.5	-0.1	-0.7	-0.6	-0.6	1.2
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.2	0.1	-0.2	-0.2	0.1
Intermittent access day 15 total infusions	1.4	1.6	2.6	-1.0	-0.3	1.6	1.6	-1.3
Intermittent access terminal intake (last 3 days)	0.6	0.7	1.1	-0.8	-0.3	1.1	1.1	-0.7
Intermittent access total infusions	0.2	0.2	0.4	-0.2	0.1	0.5	0.5	-0.6
Intermittent access day 1 locomotion	0.3	0.4	0.6	-0.5	-0.2	0.8	0.8	-0.6
Intermittent access day 15 total locomotion	2.6	2.9	4.3	-1.8	-1.1	2.1	2.1	-1.0
Intermittent access total locomotion	0.7	0.8	1.1	-1.0	-0.7	1.0	1.0	-0.4
Intermittent access standard deviation	1.9	2.0	3.3	-1.2	-0.3	1.8	1.8	-1.5
Left kidney weight	0.1	0.3	0.7	-0.5	-0.8	-0.0	-0.0	0.8
Right kidney weight	1.0	2.7	3.8	-2.0	-1.5	1.9	1.8	-0.4
Cocaine induced anxiety	1.1	1.2	2.8	-1.3	-1.7	0.4	0.4	1.2
Post-drug Anxiety	1.0	1.1	2.6	-1.3	-1.6	0.5	0.5	1.1
Baseline Anxiety	0.5	0.5	1.4	0.0	0.6	0.6	0.6	-1.2
Tail length	2.0	6.0	9.4	-2.5	-1.3	3.1	3.1	-1.8
Length with tail	1.3	4.6	7.0	-2.7	-2.1	2.4	2.4	-0.5
Length without tail	0.4	0.9	2.0	-0.9	-1.4	0.1	0.0	1.2
Times rat made contact with spout	0.5	0.6	1.3	0.9	1.1	-0.3	-0.3	-0.8
Lifetime Intake	0.1	0.1	0.1	-0.1	0.0	0.3	0.3	-0.3
Liver weight, left	1.7	2.7	4.0	2.0	1.6	-1.8	-1.8	0.4
Liver weight, right	1.1	1.9	3.0	1.4	0.7	-1.7	-1.7	1.0
Locomotor activity	2.6	4.1	7.3	-2.7	-2.6	1.6	1.8	0.6
Locomotor testing distance	1.4	2.3	4.1	-2.0	-1.8	1.4	1.5	0.2
Locomotor testing rearing	0.2	0.3	0.8	0.3	0.7	0.2	0.3	-0.9
Locomotion in novel chamber	0.1	0.2	0.3	-0.3	0.0	0.4	0.5	-0.5
Locomotion in novel chamber post-restriction	0.7	0.9	1.5	-0.7	-0.1	1.2	1.1	-1.0
Fecal boli incidents, locomotor time 1	1.5	1.6	2.5	1.6	1.2	-1.4	-1.4	0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.4	-0.4	0.2	0.2	0.2
Time >=10cm from walls, locomotor time 1	1.1	1.1	2.4	0.4	-0.4	-1.2	-1.2	1.6
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.2	0.1	0.4	0.4	-0.5
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.4	-0.1	0.5	0.5	-0.4
Rest time, locomotor task time 1	0.2	0.3	0.5	-0.7	-0.7	0.5	0.5	0.1
Distance moved, locomotor task time 1	0.8	0.9	1.8	0.3	-0.3	-1.1	-1.1	1.4
Vertical activity count, locomotor time 1	0.5	0.5	1.2	0.9	1.1	-0.3	-0.3	-0.7
Time >=10cm from walls, locomotor time 2	1.7	1.8	2.8	1.7	1.4	-1.4	-1.4	0.0
Bouts of movement, locomotor time 2	1.1	1.1	2.5	-1.3	-1.6	0.5	0.5	0.9
Total resting periods, locomotor time 2	1.1	1.1	2.5	-1.3	-1.6	0.5	0.5	1.0
Rest time, locomotor task time 2	0.6	0.7	1.4	-1.1	-1.2	0.6	0.6	0.5
Distance moved, locomotor task time 2	0.6	0.7	1.2	1.1	1.0	-0.8	-0.8	-0.1
Vertical activity count, locomotor time 2	1.2	1.3	2.8	1.5	1.7	-0.7	-0.7	-0.8
Light reinforcement 1	4.8	8.7	13.9	-3.7	-3.1	3.1	3.2	-0.4
Light reinforcement 2	1.8	2.4	4.0	-2.0	-1.7	1.5	1.7	-0.1
Bone: marrow area	0.1	0.3	0.5	0.5	0.1	-0.6	-0.7	0.5
Bone: maximum diameter	0.8	1.4	2.8	-1.5	-1.7	0.8	0.8	0.7
Bone: maximum force	1.0	1.8	2.9	1.4	0.8	-1.6	-1.7	0.9
Bone: maximum moment	0.8	1.4	2.4	1.2	0.7	-1.4	-1.5	0.8
Mean time between licks in bursts	2.9	4.1	6.4	-2.2	-1.2	2.4	2.5	-1.4
Mean num. licks in bursts	0.0	0.0	0.1	0.0	-0.1	-0.3	-0.2	0.3
Cd content in liver	0.2	0.2	0.4	0.3	0.1	-0.7	-0.5	0.4
Co content in liver	0.4	0.4	0.8	-0.7	-0.3	0.8	0.9	-0.5
Cu content in liver	0.5	0.6	1.6	-0.2	-0.8	-0.7	-0.6	1.3
Fe content in liver	0.1	0.1	0.3	0.1	0.3	0.3	0.3	-0.6
K content in liver	0.8	0.8	2.0	-0.6	-1.2	-0.4	-0.3	1.4
Mg content in liver	0.8	0.8	2.1	-0.6	-1.2	-0.5	-0.4	1.5
Mn content in liver	2.3	2.6	6.1	-1.9	-2.5	0.4	0.5	1.8
Na content in liver	1.3	1.3	2.9	0.3	-0.5	-1.4	-1.2	1.7
Rb content in liver	0.8	1.0	2.6	-0.0	-0.8	-1.0	-0.9	1.6
Se content in liver	0.2	0.2	0.3	-0.6	-0.6	0.4	0.4	0.1
Sr content in liver	0.5	0.5	1.2	0.4	0.9	0.3	0.3	-1.1
Zn content in liver	2.2	2.5	5.4	-0.5	0.6	1.7	1.8	-2.3
Bone: minimum diameter	0.1	0.1	0.3	-0.1	-0.4	-0.2	-0.3	0.6
Time in familiar zone, hab. session 1	1.9	1.8	2.8	-1.1	-0.2	1.7	1.7	-1.5
Time in novel zone, hab. session 1	1.2	1.2	2.2	0.6	-0.2	-1.3	-1.3	1.5
Total zone transitions, hab. session 1	1.9	2.6	5.7	-1.9	-2.4	0.9	0.8	1.5
Total locomotion distance, hab. session 1	2.6	3.7	8.5	-2.2	-2.9	0.8	0.7	2.0
Locomotion velocity, hab. session 1	2.9	4.1	9.0	-2.4	-3.0	1.1	1.0	1.8
Time in familiar zone, hab. session 2	4.9	5.1	8.5	-1.9	-0.7	2.9	2.8	-2.2
Time in novel zone, hab. session 2	3.7	3.6	5.8	1.7	0.6	-2.4	-2.4	1.9
Total zone transitions, hab. session 2	2.4	3.1	8.1	-1.0	-2.3	-0.8	-0.7	2.9
Total locomotion distance, hab. session 2	2.2	3.0	6.6	-2.0	-2.6	0.9	0.8	1.6
Locomotion velocity, hab. session 2	2.9	3.8	8.8	-2.2	-3.0	0.7	0.7	2.1
Novel to familiar place preference ratio	3.8	3.9	6.0	1.5	0.2	-2.5	-2.4	2.3
Novelty place preference	2.5	2.5	3.9	1.1	-0.0	-1.9	-1.9	2.0
Time in novel zone, NPP test	2.6	2.7	4.2	1.3	0.2	-2.0	-2.0	1.9
Total zone transitions, NPP test	1.2	1.7	3.9	-1.0	-1.9	-0.3	-0.2	2.0
Total locomotion distance, NPP test	1.2	1.6	4.1	-0.8	-1.7	-0.3	-0.4	2.0
Locomotion velocity, NPP test	1.2	1.7	3.8	-1.1	-1.9	-0.1	-0.1	1.9
Intraocular pressure	1.0	1.4	3.6	0.7	1.5	0.5	0.4	-1.9
Delta distance traveled before/after self-admin	1.3	1.4	2.0	-1.4	-1.0	1.4	1.4	-0.4
Delta ambulatory time before/after self-admin	1.5	1.6	2.4	-1.6	-1.2	1.4	1.4	-0.3
Parametrial fat weight	0.3	0.5	1.0	-0.4	0.0	1.0	0.8	-0.8
Pavlov. Cond. lever latency	0.6	0.7	1.9	0.5	1.2	0.2	0.3	-1.4
Pavlov. Cond. magazine entry latency	2.4	3.1	5.3	-1.9	-1.2	2.3	2.1	-0.9
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.4	-0.5	0.4	0.2	0.2
Pavlov. Cond. index score	0.6	0.8	1.5	-1.1	-1.2	0.8	0.6	0.6
Pavlov. Cond. latency score	0.9	1.1	2.4	-1.2	-1.5	0.6	0.5	1.0
Pavlov. Cond. lever contacts	0.9	1.1	2.4	-0.8	-1.5	-0.1	-0.1	1.5
Pavlov. Cond. magazine entry number	0.7	0.9	1.6	1.0	0.8	-1.2	-1.0	0.3
Pavlov. Cond. intertrial magazine entries	0.4	0.4	1.3	0.0	0.6	0.5	0.6	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.7	-1.3	-1.3	1.0	0.9	0.4
Pavlov. Cond. response bias	1.0	1.2	1.8	-1.3	-1.0	1.3	1.2	-0.2
Pavlov. Cond. lever latency	0.4	0.5	0.8	0.6	0.2	-0.9	-0.9	0.7
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	-0.5	-0.2	0.6	0.6	-0.4
Pavlov. Cond. change in total contacts	0.4	0.6	1.0	-0.6	-0.1	0.8	1.0	-0.9
Pavlov. Cond. index score	0.4	0.6	0.9	-0.6	-0.1	0.9	1.0	-0.8
Pavlov. Cond. latency score	0.4	0.5	0.7	-0.7	-0.3	0.8	0.9	-0.5
Pavlov. Cond. lever contacts	0.5	0.7	1.2	-0.4	0.2	1.0	1.0	-1.1
Pavlov. Cond. magazine entry number	0.4	0.5	0.7	0.7	0.4	-0.8	-0.9	0.5
Pavlov. Cond. intertrial magazine entries	0.4	0.6	1.2	0.9	1.1	-0.3	-0.4	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.9	-0.7	-0.3	0.9	0.9	-0.6
Pavlov. Cond. response bias	1.1	1.5	2.5	-0.9	-0.1	1.5	1.6	-1.4
Time in closed arm before self-admin	1.2	1.4	3.6	0.0	-0.9	-1.1	-1.1	1.9
Time in closed arm after self-admin	0.0	0.0	0.1	-0.0	0.1	0.2	0.2	-0.3
Time in open arm before self-admin	0.5	0.5	0.8	-0.6	-0.1	0.9	0.9	-0.8
Time in open arm after self-admin	0.6	0.7	1.0	1.0	0.8	-0.9	-0.9	0.2
Bone: periosteal estimation	0.4	0.8	1.6	0.3	-0.3	-1.0	-1.1	1.3
Bone: periosteal perimeter	0.2	0.4	0.8	-0.5	-0.9	-0.0	-0.1	0.9
Bone: post-yield work	0.5	0.7	1.1	1.1	1.0	-0.8	-0.8	-0.1
Progressive ratio test 1 active lever presses	0.3	0.3	0.6	0.5	0.8	-0.0	-0.0	-0.7
Progressive ratio test 1 breakpoint	0.3	0.3	0.6	0.6	0.8	-0.1	-0.1	-0.6
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.2	-0.1	0.2	0.2	-0.2
Progressive ratio test 2 active lever presses	0.4	0.4	1.0	0.1	0.6	0.5	0.5	-1.0
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	-0.2	0.2	0.5	0.5	-0.7
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.2	-0.2	0.1	0.1	0.1
Incentive Sensitization - Responses	0.3	0.3	0.8	0.2	0.6	0.4	0.4	-0.9
Incentive Sensitization - Breakpoint	0.3	0.3	0.7	0.1	0.4	0.5	0.5	-0.8
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.2
Progressive ratio	0.1	0.1	0.2	0.4	0.4	-0.1	-0.3	-0.0
Food seeking constrained by brief footshock	0.4	0.5	1.0	-0.9	-1.0	0.5	0.4	0.5
Seeking ratio, punishment vs. effort	0.3	0.4	0.8	-0.8	-0.9	0.2	0.4	0.4
Retroperitoneal fat weight	0.2	0.6	1.0	1.0	0.9	-0.6	-0.8	0.0
Reaction time number correct	1.4	2.1	4.8	1.6	2.2	-0.4	-0.4	-1.6
Reaction time mean minus median	0.4	0.6	0.9	-0.5	-0.0	1.0	1.0	-0.9
Reaction time mean minus median AUC	0.2	0.2	0.6	-0.3	-0.6	-0.1	-0.2	0.8
Reaction time num false alarms	0.8	1.1	2.6	1.1	1.6	-0.3	-0.1	-1.4
Reaction time num false alarms AUC	1.1	1.5	3.4	1.3	1.8	-0.3	-0.1	-1.6
Reaction time trials correct on left	1.4	2.1	4.8	1.6	2.2	-0.4	-0.4	-1.6
Reaction time trials on left	1.3	1.9	4.4	1.6	2.1	-0.4	-0.4	-1.5
Reaction time mean	0.1	0.1	0.2	-0.1	-0.3	-0.3	-0.2	0.4
Reaction time mean AUC	0.1	0.1	0.3	-0.0	-0.3	-0.4	-0.3	0.5
Median of all reaction times	0.3	0.4	0.8	0.3	-0.1	-0.9	-0.7	0.8
Reaction time omissions	0.3	0.4	0.7	-0.8	-0.8	0.5	0.5	0.3
Reaction time false alarm rate	0.1	0.1	0.2	0.4	0.5	-0.3	-0.1	-0.3
Reaction time premature initiation rate	0.9	1.2	2.0	-0.8	-0.1	1.4	1.3	-1.2
Reaction time premature initiations	1.3	1.8	4.5	0.0	1.0	1.3	1.2	-2.1
Std. dev. reaction times	0.1	0.1	0.2	-0.3	-0.1	0.4	0.4	-0.3
Reaction time trials completed	1.3	1.9	4.4	1.6	2.1	-0.4	-0.4	-1.5
Reaction time trials AUC	1.6	2.3	5.3	1.7	2.3	-0.3	-0.3	-1.8
Run reversals in cocaine runway, females	0.4	0.4	0.6	-0.7	-0.6	0.7	0.6	0.0
Run reversals in cocaine runway, males	1.4	1.3	2.2	-1.5	-1.2	1.2	1.2	-0.1
Latency to leave start box in cocaine runway	1.2	1.3	3.0	-1.4	-1.7	0.2	0.5	1.1
Latency to leave start box in cocaine runway, F	1.6	1.7	4.5	-0.7	-1.6	-0.9	-0.7	2.1
Latency to leave start box in cocaine runway, M	2.2	2.1	3.5	-1.0	-0.1	1.8	1.9	-1.7
Std. dev. time between licks in bursts	0.5	0.6	1.0	-1.0	-0.9	0.7	0.8	0.1
Total sessions with >9 infusions	0.1	0.1	0.2	0.0	-0.2	-0.3	-0.3	0.5
Short access day 1 total inactive lever presses	0.1	0.1	0.1	-0.3	-0.3	0.3	0.3	-0.0
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.2	0.3	-0.0	-0.0	-0.3
Short access day 1 total infusions	0.4	0.4	0.9	-0.8	-0.9	0.2	0.2	0.6
Short access day 10 total infusions	0.2	0.2	0.6	0.2	0.5	0.4	0.4	-0.8
Short access total infusions	0.0	0.0	0.0	-0.0	-0.1	-0.1	-0.1	0.1
Short access day 1 locomotion	0.8	0.8	1.4	-1.2	-1.1	0.9	0.9	0.1
Short access day 10 total locomotion	2.6	2.9	4.6	-1.7	-0.8	2.1	2.1	-1.3
Short access total locomotion	0.5	0.5	0.7	-0.9	-0.6	0.8	0.8	-0.3
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.5	0.5	-0.3	-0.3	-0.2
Compulsive drug intake	1.2	1.2	1.9	0.8	0.1	-1.4	-1.4	1.3
One hour access (shock baseline)	0.5	0.5	1.4	0.2	0.7	0.6	0.6	-1.2
Social response proportion	1.1	1.2	2.4	-1.4	-1.6	0.6	0.7	0.7
Social responses	5.0	6.4	10.5	-3.2	-2.7	2.7	2.7	-0.2
Social time	0.5	0.6	1.0	0.6	0.1	-1.0	-1.0	0.8
Soleus weight	6.7	19.7	27.5	5.2	3.9	-5.2	-5.2	1.4
Bone: stiffness	2.4	3.7	5.9	2.1	1.3	-2.3	-2.4	1.2
Tibialis anterior weight	0.9	3.1	4.6	2.1	1.6	-2.0	-2.1	0.5
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.9	-1.0	-1.4	0.4	0.4	0.9
Time to tail flick, vehicle, after self-admin	0.7	0.7	2.1	0.2	0.9	0.6	0.6	-1.4
Time to tail flick, test, before self-admin	0.6	0.6	1.4	-0.9	-1.2	0.2	0.2	0.9
Time to tail flick, test, after self-admin	0.4	0.4	0.7	-0.8	-0.8	0.5	0.5	0.3
Delta time to tail flick, vehicle, before/after SA	1.4	1.4	3.3	1.2	1.8	-0.2	-0.2	-1.5
Delta time to tail flick, test, before/after SA	0.5	0.4	1.1	0.0	0.5	0.6	0.6	-1.0
Tibia length	0.6	1.7	2.8	-1.4	-0.8	1.6	1.7	-0.8
Ambulatory time before self-admin	0.4	0.4	0.7	0.5	0.1	-0.8	-0.8	0.7
Ambulatory time after self-admin	0.3	0.3	0.5	-0.7	-0.7	0.4	0.4	0.2
Bone: tissue strength	1.3	1.3	2.2	1.0	0.4	-1.5	-1.4	1.0
Total heroin consumption	1.5	1.7	2.4	-1.6	-1.1	1.5	1.5	-0.5
Bone: trabecular number	1.0	1.6	3.6	-1.6	-1.9	0.4	0.6	1.1
Bone: trabecular spacing	2.3	3.0	6.8	1.8	2.6	-0.1	-0.2	-2.2
Bone: trabecular thickness	3.5	4.2	10.1	-1.4	-2.7	-1.0	-0.8	3.2
Bone: trabecular tissue density	1.2	1.7	2.5	1.6	1.3	-1.4	-1.4	0.2
Water consumed over 24 hours	0.6	0.7	1.3	0.5	-0.0	-1.1	-1.0	1.0
Number of responses in last shaping day	0.1	0.1	0.1	-0.2	0.0	0.4	0.4	-0.3