Arhgap27

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	XM_006247525.4	0.04	0.03	1.5e-03	0	0.01	0	0	1.6e-01	4.4e-02	2.9e-01	1.1e-01
2	Adipose	alternative TSS	XM_006247525.4	0.04	0.03	1.1e-03	0	0.01	0	0	1.3e-01	3.1e-02	2.1e-01	9.9e-02
3	Adipose	isoform ratio	XM_006247525.4	0.04	0.03	1.1e-03	0	0.01	0.01	0.01	1.0e-01	2.5e-02	6.4e-02	6.7e-02
4	NAcc	gene expression	Arhgap27	0.03	0.02	1.7e-03	0.01	0.02	0.02	0.02	1.8e-02	1.2e-03	1.4e-03	3.4e-03
5	Adipose	isoform ratio	XM_008768291.3	0.06	0.05	3.1e-03	0	0	-0	-0	2.7e-01	2.0e-01	5.5e-01	5.9e-01
6	OFC	gene expression	Arhgap27	0.15	0.09	6.0e-03	0.02	0.06	0.01	0.01	1.1e-01	2.0e-02	1.6e-01	2.2e-01
7	Adipose	gene expression	Arhgap27	0.18	0.08	0.0e+00	0.16	0.13	0.13	0.15	1.3e-17	1.0e-14	2.8e-14	1.7e-16
8	BLA	gene expression	Arhgap27	0.06	0.04	5.8e-03	0.03	0.01	0	0.01	8.6e-03	5.2e-02	2.2e-01	1.5e-01
9	PL	gene expression	Arhgap27	0.04	0.03	3.8e-04	0.03	0.03	0.02	0.02	7.7e-04	8.2e-04	9.3e-04	2.1e-03
10	pVTA	isoform ratio	XM_006247523.4	0.14	0.07	1.0e-03	0.11	0.06	0.04	0.07	2.4e-05	2.2e-03	5.0e-03	4.2e-04
11	Brain	alternative TSS	XM_008768291.3	0.03	0.02	6.2e-03	0.02	0.01	0.03	0.02	8.1e-03	2.1e-02	1.5e-03	8.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	3.3	5.5	9.5	-2.9	-3.0	-3.0	2.8	2.8	3.1	-2.0	-0.7	-0.7	-0.7	1.6
Area under the delay curve	0.1	0.1	0.2	0.1	0.2	0.2	-0.4	-0.2	-0.4	0.2	0.0	-0.3	-0.5	-0.1
BMI with tail	1.2	3.7	15.4	2.2	2.2	2.3	-1.5	-0.7	-1.5	1.5	0.7	1.2	1.5	-3.9
BMI without tail	0.3	0.6	1.5	0.9	0.9	0.9	0.4	-0.4	0.2	0.5	-0.9	0.4	1.0	-1.2
Body weight	0.3	1.4	8.3	0.1	0.2	0.3	0.7	1.6	0.5	-1.0	-1.5	-0.6	-0.0	-2.9
Weight adjusted by age	0.2	0.3	1.3	-0.2	-0.1	-0.2	-0.6	0.1	-0.6	0.0	-0.2	-0.9	-1.1	0.1
Bone surface	6.7	11.9	18.6	-4.2	-4.2	-4.2	3.6	4.3	3.8	-3.6	-1.9	-2.2	-2.5	2.0
Bone volume	5.2	8.8	13.7	-3.7	-3.7	-3.7	3.4	3.6	3.6	-2.8	-1.5	-1.6	-1.7	1.8
Breakpoint value in progressive ratio session	0.7	0.8	2.2	-0.5	-0.4	-0.4	0.4	0.1	0.1	-1.1	-1.2	-1.5	-1.4	0.9
Number of licking bursts	0.9	1.0	3.4	1.0	1.1	1.1	-1.5	-0.2	-1.5	0.1	0.5	-0.0	0.0	-1.8
Context. condit. distance diff. score	1.7	2.0	3.0	1.6	1.6	1.6	-1.5	-1.6	-1.4	1.7	1.1	0.9	1.1	-1.3
Locomotion velocity, session 1	0.3	0.4	1.5	-0.4	-0.5	-0.5	0.8	0.1	0.8	-0.3	-0.5	-0.6	0.1	1.2
Locomotion distance, session 1	0.1	0.1	0.3	-0.0	-0.1	-0.1	0.6	-0.1	0.5	0.3	-0.4	0.1	0.3	0.4
Locomotion velocity, session 2	0.4	0.4	2.4	-0.5	-0.6	-0.7	0.6	-0.2	0.8	0.1	0.2	-0.0	0.2	1.5
Locomotion distance, session 2	0.1	0.2	0.6	-0.1	-0.1	-0.1	0.7	-0.2	0.6	-0.0	-0.5	-0.0	0.0	0.8
Locomotion velocity, session 3	0.3	0.3	0.8	-0.5	-0.6	-0.6	0.4	0.7	0.6	0.2	0.9	0.7	0.6	-0.3
Locomotion distance, session 3	0.2	0.2	1.1	-0.1	-0.1	-0.1	-0.5	0.3	-0.3	0.3	1.0	0.2	0.0	-0.6
Stereotopy head waving bouts, day 3	0.7	0.8	2.7	-0.3	-0.5	-0.4	0.5	0.0	0.8	0.8	1.3	1.6	1.4	0.3
Stereotopy head waving duration, day 3	0.4	0.4	1.4	0.3	0.2	0.3	-0.1	-0.6	0.0	0.9	0.8	1.2	1.1	-0.0
Locomotion velocity, session 7	1.0	1.0	3.3	1.0	0.8	0.9	-0.6	-0.9	-0.4	1.4	1.1	1.1	1.8	-0.4
Locomotion distance, session 7	0.5	0.6	1.3	0.9	0.8	0.8	-0.7	-1.0	-0.6	1.1	0.9	0.3	0.7	-0.1
Stereotopy head waving bouts, day 7	0.5	0.6	1.4	-0.9	-1.0	-1.0	0.1	1.0	0.5	-0.7	1.2	0.4	0.2	0.4
Stereotopy head waving duration, day 7	0.4	0.4	2.2	0.0	-0.1	-0.1	-0.5	-0.1	-0.1	0.2	1.5	1.1	1.0	0.2
Locomotion velocity, session 8	0.4	0.5	1.0	0.9	0.8	0.9	0.2	-0.6	0.1	0.5	-0.6	0.6	1.0	-0.9
Locomotion distance, session 8	0.6	0.9	2.2	1.1	1.1	1.1	-0.6	-1.5	-0.6	1.4	0.4	0.7	0.8	-0.2
Degree of sensitization distance	0.3	0.3	0.7	0.8	0.8	0.9	-0.2	-0.8	-0.4	0.2	-0.7	-0.4	0.0	-0.1
Degree of sensitization stereotypy	0.2	0.2	1.1	-0.4	-0.4	-0.4	-0.4	0.3	-0.1	-0.3	1.1	0.5	0.3	0.2
Conditioned locomotion	0.1	0.1	0.6	0.2	0.2	0.2	-0.1	-0.2	-0.1	0.1	0.3	0.8	0.2	-0.2
Cocaine response after cond. corrected	0.4	0.5	1.5	-0.6	-0.7	-0.7	0.2	1.0	0.5	-0.1	0.8	1.2	0.3	-0.7
Cocaine response after cond. not corrected	0.9	1.0	2.1	-1.2	-1.3	-1.3	0.8	1.5	1.1	-0.5	0.7	1.0	0.2	0.2
Cocaine response before conditioning	0.6	0.7	2.6	-0.9	-1.0	-1.0	1.0	0.5	1.0	-0.5	-0.4	-0.5	-0.1	1.6
Saline control response	0.2	0.2	1.4	0.4	0.4	0.5	0.2	-0.3	-0.1	-0.3	-1.2	-0.3	-0.2	-0.3
Bone: connectivity density	4.4	7.0	10.9	-3.3	-3.3	-3.3	2.8	3.0	3.0	-2.6	-1.3	-1.5	-1.6	2.2
Bone: cortical apparent density	2.5	3.3	9.1	1.4	1.2	1.1	-1.0	-2.1	-0.7	2.4	2.2	3.0	2.5	0.3
Bone: cortical area	3.6	5.4	10.5	-2.9	-2.9	-2.9	2.7	3.2	2.9	-2.1	-0.7	-0.6	-1.1	1.0
Bone: cortical porosity	12.1	13.2	17.9	-4.1	-4.0	-3.9	3.8	4.2	3.7	-3.9	-3.4	-3.3	-3.3	1.9
Bone: cortical porosity	7.9	8.5	13.9	-3.3	-3.2	-3.2	3.1	3.7	3.1	-3.1	-2.6	-2.5	-2.4	1.0
Bone: cortical thickness	1.2	2.0	4.0	-1.2	-1.4	-1.4	1.0	1.6	1.7	0.1	2.0	1.9	1.7	-0.0
Bone: cortical thickness	1.7	1.9	3.9	-1.7	-1.8	-1.8	0.8	1.5	1.4	-0.4	2.0	0.9	0.5	1.3
Bone: cortical tissue density	2.4	3.2	8.2	1.4	1.2	1.1	-1.0	-2.1	-0.7	2.4	2.1	2.9	2.4	0.4
Condit. Reinf. active minus inactive responses	1.3	1.4	4.0	-1.0	-0.8	-0.9	0.6	0.5	0.4	-1.1	-1.7	-1.8	-2.0	1.3
Condit. Reinf. active-inactive response ratio	0.6	0.6	2.8	-0.3	-0.2	-0.3	-0.3	-0.2	-0.4	-0.3	-0.7	-1.6	-1.7	0.8
Condit. Reinf. active responses	1.2	1.5	3.6	-1.0	-1.0	-1.0	1.2	0.5	0.9	-1.0	-1.9	-1.3	-1.6	1.5
Condit. Reinf. inactive responses	0.9	1.1	3.1	-0.9	-1.0	-1.0	1.8	0.8	1.8	-0.6	-0.8	0.6	0.4	0.9
Incentive salience index mean	1.6	1.9	3.8	-1.3	-1.2	-1.2	0.9	0.7	0.8	-1.2	-1.7	-1.8	-2.0	1.6
Condit. Reinf. lever presses	0.3	0.4	1.0	-0.6	-0.6	-0.6	0.8	0.1	0.7	-0.2	-1.0	-0.6	-0.5	1.0
Condit. Reinf. active minus inactive responses	5.0	6.2	8.4	-2.8	-2.7	-2.7	2.4	2.1	2.3	-2.5	-2.0	-2.4	-2.4	2.9
Condit. Reinf. active-inactive response ratio	4.8	5.0	7.5	-2.4	-2.2	-2.3	1.8	1.9	1.6	-2.3	-1.9	-2.7	-2.7	2.5
Condit. Reinf. active responses	5.1	7.1	11.9	-2.8	-2.7	-2.8	2.6	1.9	2.4	-2.6	-2.3	-2.7	-2.7	3.5
Condit. Reinf. inactive responses	1.0	1.2	4.3	-0.9	-1.0	-1.0	1.5	0.1	1.4	-0.7	-1.1	-0.4	-0.4	2.1
Condit. Reinf. lever presses	1.6	2.2	3.8	-1.6	-1.5	-1.5	1.5	1.0	1.3	-1.4	-1.4	-1.2	-1.6	2.0
Condit. Reinf. lever reinforcers received	4.3	6.0	10.5	-2.7	-2.6	-2.6	2.4	1.8	2.3	-2.4	-2.0	-2.3	-2.4	3.2
Conditioned reinforcement - actives	0.3	0.3	1.1	0.3	0.4	0.4	-0.1	0.0	-0.4	-0.5	-0.9	-1.1	-0.7	-0.3
Conditioned reinforcement - inactives	1.7	2.0	3.0	-1.5	-1.5	-1.5	1.7	1.5	1.7	-1.5	-1.3	-0.9	-0.7	1.1
Conditioned locomotion	0.5	0.7	1.8	-0.7	-0.6	-0.6	0.6	0.9	0.4	-0.8	-1.2	-1.3	-1.0	-0.0
Patch foraging indifference point 0 sec	1.3	2.0	5.7	-1.4	-1.5	-1.5	2.4	1.1	2.4	-0.8	-0.9	0.0	0.1	1.4
Patch foraging indifference point AUC	0.3	0.4	1.4	0.0	0.1	0.1	0.1	0.3	-0.2	-0.7	-0.9	-1.1	-1.2	-0.4
Delay disc. indifference point, 0s delay	0.2	0.2	0.7	0.4	0.5	0.4	-0.6	-0.8	-0.7	0.5	0.3	-0.2	-0.4	0.3
Delay disc. indifference point, 16s delay	0.3	0.3	0.8	0.3	0.4	0.4	-0.8	-0.1	-0.7	0.5	0.6	0.1	-0.1	-0.9
Delay disc. indifference point, 2s delay	1.7	1.9	3.2	-1.4	-1.4	-1.4	1.4	0.9	1.3	-1.0	-1.4	-1.4	-1.5	1.8
Delay disc. indifference point, 24s delay	0.2	0.2	0.8	-0.1	0.0	0.0	-0.2	0.1	-0.3	-0.4	-0.5	-0.9	-0.8	0.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.0	0.1	0.0	-0.4	-0.4	-0.4	0.4	0.4	-0.2	-0.3	0.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	0.1	0.1	0.1	-0.2	-0.2	-0.1	0.3	0.5	0.4	0.2	0.4
Indifference point function ln k	1.2	1.7	3.2	-1.7	-1.8	-1.8	1.5	1.3	1.6	-1.0	-0.1	-0.1	-0.2	1.3
Indifference point function log k	1.2	1.7	3.2	-1.7	-1.8	-1.8	1.5	1.3	1.6	-1.0	-0.1	-0.1	-0.2	1.3
Patch foraging total patch changes 0 sec	1.7	2.8	7.3	-1.7	-1.8	-1.8	2.7	1.5	2.7	-1.1	-1.1	-0.1	-0.0	1.4
Patch foraging total patch changes 12 sec	1.2	1.5	4.0	-1.0	-1.0	-1.0	2.0	0.7	1.8	-0.9	-1.4	-0.8	-0.9	1.3
Patch foraging total patch changes 18 sec	0.4	0.6	0.9	-0.8	-0.8	-0.8	1.0	0.9	0.9	-0.6	-0.5	-0.5	-0.8	0.5
Patch foraging total patch changes 24 sec	1.8	2.3	5.3	-1.6	-1.7	-1.7	2.3	1.5	2.3	-1.2	-0.8	-0.3	-0.2	1.3
Patch foraging total patch changes 6 sec	0.4	0.7	1.8	-0.8	-0.8	-0.8	1.3	0.9	1.3	-0.6	-0.6	-0.2	-0.2	0.4
Patch foraging time to switch 0 sec	0.1	0.2	0.6	0.5	0.5	0.5	-0.4	-0.7	-0.5	0.8	-0.2	-0.3	-0.1	0.3
Patch foraging water rate 0 sec	0.2	0.3	0.6	-0.5	-0.5	-0.5	0.6	0.7	0.8	-0.3	0.2	0.6	0.4	-0.5
Patch foraging water rate 12 sec	0.5	0.8	4.3	-0.5	-0.6	-0.6	-0.5	0.8	-0.1	-0.1	2.1	1.2	0.7	-0.8
Patch foraging water rate 18 sec	0.9	1.2	3.2	-0.7	-0.9	-0.8	0.9	0.7	1.3	0.2	1.3	1.8	1.8	0.3
Patch foraging water rate 24 sec	0.4	0.6	2.3	-0.1	-0.2	-0.2	0.0	-0.3	0.3	0.9	1.2	1.5	1.2	0.3
Patch foraging water rate 6 sec	1.0	1.4	2.7	-1.6	-1.6	-1.6	1.1	1.5	1.4	-1.2	-0.1	-0.2	-0.5	0.7
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	2.0	0.7	0.9	0.9	-0.7	-0.3	-1.1	-0.1	-0.9	-1.4	-1.1	-0.9
Distance traveled before self-admin	0.3	0.3	1.4	-0.3	-0.2	-0.2	-0.1	0.0	-0.2	-0.4	-0.7	-1.2	-1.2	0.3
Distance traveled after self-admin	0.3	0.3	0.8	0.5	0.6	0.6	-0.7	-0.4	-0.8	0.5	-0.2	-0.3	-0.4	-0.9
Extensor digitorum longus weight	4.2	16.5	28.5	4.9	5.1	5.1	-4.9	-4.2	-5.3	3.4	1.5	1.1	1.2	-4.3
Bone: elastic displacement	0.6	0.7	1.5	-1.1	-1.1	-1.1	0.5	1.2	0.8	-0.7	0.6	0.3	0.1	0.5
Bone: elastic work	2.1	2.7	4.6	-2.0	-2.1	-2.0	1.8	2.1	2.0	-1.6	-0.5	-0.8	-0.6	1.2
Bone: endosteal estimation	3.7	8.1	18.5	-2.7	-2.4	-2.4	2.3	2.5	1.8	-3.0	-3.5	-3.8	-4.3	1.4
Bone: endosteal perimeter	5.0	10.4	21.2	-3.1	-2.8	-2.8	2.6	3.3	2.0	-3.9	-3.9	-3.8	-4.6	1.0
Epididymis fat weight	0.1	0.3	1.3	0.2	0.2	0.2	0.2	0.6	0.1	-0.7	-0.6	-0.4	0.0	-1.1
Delta time in closed arm before/after self-admin	2.1	2.1	5.5	1.3	1.1	1.2	-0.3	-0.5	-0.1	1.6	0.8	2.2	2.4	-2.1
Delta time in open arm before/after self-admin	0.7	0.7	1.7	0.5	0.6	0.6	-0.6	-1.1	-0.9	-0.2	-0.8	-1.3	-1.0	0.6
Diff in mean of infusions in LGA sessions	0.3	0.3	1.1	-0.2	-0.1	-0.1	0.2	0.3	0.0	-0.9	-1.0	-1.0	-0.6	-0.1
Delay discount exponential model param	0.1	0.1	0.4	-0.1	-0.1	-0.1	0.2	0.0	0.3	0.0	0.2	0.5	0.6	0.2
Extinction: sum of active levers before priming	0.2	0.2	0.4	0.6	0.6	0.6	-0.1	-0.5	-0.3	0.2	-0.4	-0.0	0.4	-0.4
Active lever presses in extinction session 6	2.3	2.2	5.1	-1.2	-1.0	-1.0	0.9	1.3	0.6	-2.1	-1.9	-2.3	-2.2	0.2
Bone: final force	2.4	3.8	8.3	-2.3	-2.5	-2.4	2.6	2.4	2.9	-1.5	-0.1	-0.2	-0.1	1.2
Bone: final moment	2.7	4.4	9.4	-2.5	-2.7	-2.6	2.7	2.6	3.1	-1.7	-0.2	-0.3	-0.1	1.4
Food consumed during 24 hour testing period	0.2	0.2	0.7	0.3	0.3	0.4	-0.1	0.1	-0.2	-0.5	-0.8	-0.4	0.0	-0.8
Glucose	1.0	1.5	2.1	1.3	1.3	1.3	-1.2	-1.3	-1.2	1.4	1.3	1.1	1.0	-0.8
Heart weight	0.5	0.7	4.2	-0.1	-0.0	0.0	-0.2	1.3	-0.2	-1.1	-0.4	-0.6	-0.3	-2.1
Delay discount hyperbolic model param	0.1	0.1	0.4	0.1	0.0	0.0	0.0	0.0	0.1	0.0	0.3	0.6	0.7	-0.2
Intermittent access intake day 1-15 change	0.2	0.2	0.7	0.2	0.1	0.1	0.6	-0.1	0.5	0.8	-0.5	0.3	0.5	0.2
Intermittent access intake escalation	0.4	0.4	1.2	0.6	0.5	0.6	0.1	-0.4	0.1	1.1	0.1	0.7	1.0	-0.4
Intermittent access intake escalation 2	0.2	0.2	0.5	0.2	0.1	0.2	0.7	0.2	0.6	0.3	-0.6	0.1	0.5	-0.4
Intermitt. access day 1 inactive lever presses	4.5	4.9	7.5	-2.3	-2.2	-2.2	2.4	2.7	2.3	-2.7	-2.3	-2.0	-1.6	0.8
Intermitt. access day 15 inactive lever presses	7.5	8.3	11.0	-3.3	-3.2	-3.3	2.6	2.8	2.5	-3.0	-2.2	-2.8	-2.8	2.9
Intermitt. access escalation Index	0.8	0.7	1.5	0.9	0.9	0.9	-1.2	-0.7	-1.2	0.3	0.6	0.4	0.1	-1.1
Intermittent access day 1 total infusions	0.2	0.2	0.8	-0.0	0.1	0.1	-0.3	0.2	-0.4	-0.4	-0.5	-0.9	-0.8	-0.3
Intermittent access day 15 total infusions	0.3	0.4	0.7	0.8	0.8	0.8	-0.2	-0.6	-0.4	0.8	-0.6	-0.1	0.1	-0.6
Intermittent access terminal intake (last 3 days)	0.3	0.3	1.3	-0.1	-0.1	-0.1	0.4	0.2	0.2	-0.2	-1.1	-1.0	-0.9	0.1
Intermittent access total infusions	0.2	0.2	1.1	0.3	0.4	0.4	0.0	-0.1	-0.2	-0.1	-1.1	-0.7	-0.4	-0.5
Intermittent access day 1 locomotion	0.8	0.8	2.9	-0.4	-0.3	-0.3	0.7	0.9	0.4	-0.8	-1.7	-1.4	-1.3	-0.4
Intermittent access day 15 total locomotion	0.3	0.3	1.9	0.2	0.2	0.2	0.6	0.1	0.4	0.4	-1.4	-0.5	-0.3	-0.4
Intermittent access total locomotion	1.1	1.3	5.6	-0.6	-0.5	-0.5	1.1	1.1	0.8	-0.7	-2.4	-1.6	-1.3	-0.3
Intermittent access standard deviation	1.2	1.3	3.5	-0.8	-0.8	-0.8	1.9	0.7	1.7	-0.4	-1.8	-0.7	-0.1	1.1
Left kidney weight	0.2	0.6	2.3	-0.7	-0.7	-0.6	-0.1	1.5	0.1	-0.9	0.4	-0.1	-0.5	-1.3
Right kidney weight	0.2	0.6	3.3	-0.3	-0.3	-0.3	-0.2	1.3	0.1	-0.7	0.8	0.5	0.4	-1.8
Cocaine induced anxiety	0.6	0.6	1.5	-0.8	-0.9	-0.9	0.4	1.2	0.8	-0.2	0.9	1.0	0.7	-0.5
Post-drug Anxiety	0.3	0.4	1.6	-0.4	-0.4	-0.4	-0.2	1.1	-0.0	-0.5	0.4	0.1	-0.1	-1.3
Baseline Anxiety	0.2	0.2	0.5	0.3	0.4	0.4	-0.5	-0.2	-0.6	-0.2	-0.3	-0.7	-0.6	-0.4
Tail length	0.4	1.1	3.0	-0.9	-0.8	-0.8	1.4	0.8	1.2	-1.2	-1.7	-1.0	-0.5	0.7
Length with tail	0.8	2.8	5.7	-1.7	-1.6	-1.6	1.6	2.4	1.6	-2.3	-1.7	-1.4	-1.1	-0.2
Length without tail	0.8	1.8	6.0	-1.5	-1.5	-1.4	0.9	2.4	1.1	-1.8	-0.1	-0.6	-0.7	-0.8
Times rat made contact with spout	0.2	0.2	0.7	0.0	-0.0	-0.0	0.0	0.4	0.2	-0.6	0.0	0.7	0.8	-0.7
Lifetime Intake	0.5	0.6	1.7	-0.5	-0.5	-0.4	0.7	0.7	0.5	-1.0	-1.3	-1.1	-0.9	0.1
Liver weight, left	0.5	0.8	1.8	-1.0	-1.1	-1.1	1.2	0.8	1.3	-0.7	-0.2	-0.4	-0.2	1.1
Liver weight, right	0.6	1.0	3.6	-0.1	-0.3	-0.3	0.3	0.3	0.8	0.5	1.7	1.8	1.9	0.1
Locomotor activity	1.5	2.4	4.4	-1.3	-1.2	-1.3	1.7	1.2	1.4	-1.9	-2.1	-1.9	-1.5	1.3
Locomotor testing distance	3.1	5.1	9.8	-1.9	-1.8	-1.8	2.4	1.3	1.9	-2.3	-3.1	-2.9	-2.5	2.4
Locomotor testing rearing	1.2	1.8	5.3	-0.7	-0.5	-0.6	1.3	-0.0	0.8	-0.9	-2.3	-2.1	-1.8	1.8
Locomotion in novel chamber	0.6	0.7	3.1	-0.9	-0.8	-0.8	0.3	0.4	0.2	-0.5	-0.7	-1.2	-1.8	0.8
Locomotion in novel chamber post-restriction	1.0	1.3	2.4	-1.2	-1.2	-1.2	1.5	1.3	1.5	-1.0	-1.1	-0.7	-0.6	0.8
Fecal boli incidents, locomotor time 1	0.1	0.1	0.5	0.2	0.2	0.2	0.1	0.1	0.1	0.1	0.3	0.5	0.7	0.0
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.3	-0.2	-0.2	0.1	0.3	0.0	-0.3	-0.2	-0.4	-0.4	-0.1
Time >=10cm from walls, locomotor time 1	0.3	0.4	2.0	-0.0	-0.0	-0.1	-1.0	-0.1	-0.7	0.4	1.4	0.4	-0.2	-0.1
Bouts of movement, locomotor time 1	0.8	0.9	2.2	0.8	0.7	0.7	-1.1	-0.5	-0.9	0.9	1.5	1.1	0.9	-1.0
Total resting periods, locomotor time 1	0.8	0.9	2.8	0.7	0.6	0.6	-1.2	-0.3	-0.9	0.7	1.7	1.1	0.9	-1.1
Rest time, locomotor task time 1	0.2	0.2	1.4	-0.1	-0.2	-0.2	-0.3	-0.1	-0.1	0.2	1.2	0.5	0.2	0.4
Distance moved, locomotor task time 1	0.2	0.3	1.2	-0.0	0.1	0.1	0.2	0.3	-0.0	-0.5	-1.1	-0.7	-0.6	-0.7
Vertical activity count, locomotor time 1	0.1	0.1	0.4	-0.2	-0.2	-0.1	0.1	0.2	0.0	-0.1	-0.6	-0.5	-0.7	-0.4
Time >=10cm from walls, locomotor time 2	0.7	0.7	1.3	-1.2	-1.1	-1.2	0.5	1.1	0.7	-0.9	-0.0	-0.5	-0.9	0.6
Bouts of movement, locomotor time 2	0.3	0.4	0.7	-0.8	-0.8	-0.8	0.5	0.8	0.6	-0.6	0.2	-0.1	-0.3	0.5
Total resting periods, locomotor time 2	0.1	0.2	0.5	-0.5	-0.5	-0.5	0.1	0.5	0.2	-0.2	0.7	0.3	0.1	0.2
Rest time, locomotor task time 2	0.7	0.8	1.6	0.8	0.8	0.8	-1.1	-0.4	-1.0	0.6	1.3	0.8	0.7	-1.2
Distance moved, locomotor task time 2	0.1	0.1	0.4	-0.2	-0.2	-0.2	0.3	0.1	0.2	-0.2	-0.6	-0.4	-0.5	0.2
Vertical activity count, locomotor time 2	0.7	0.7	1.1	-0.9	-0.9	-0.9	0.9	0.5	0.9	-0.7	-0.9	-0.7	-0.9	1.0
Light reinforcement 1	1.1	2.0	3.7	-1.6	-1.6	-1.6	1.9	1.4	1.9	-1.5	-0.8	-0.8	-0.4	1.5
Light reinforcement 2	1.6	2.1	3.6	-1.7	-1.8	-1.8	1.8	1.3	1.9	-1.3	-0.9	-0.6	-0.4	1.5
Bone: marrow area	3.7	8.0	17.8	-2.7	-2.5	-2.4	2.3	2.5	1.8	-3.0	-3.4	-3.7	-4.2	1.4
Bone: maximum diameter	3.5	6.5	9.4	-3.1	-3.0	-3.0	2.7	3.1	2.7	-2.6	-1.7	-1.5	-2.4	1.3
Bone: maximum force	2.0	3.5	6.4	-2.2	-2.3	-2.2	2.5	2.5	2.5	-1.6	-0.9	-0.7	-0.8	0.6
Bone: maximum moment	2.4	4.1	7.4	-2.4	-2.5	-2.4	2.6	2.6	2.7	-1.7	-0.9	-0.8	-0.9	0.8
Mean time between licks in bursts	1.5	2.1	8.2	1.5	1.6	1.6	-1.6	-0.5	-1.6	0.8	0.9	0.1	0.7	-2.9
Mean num. licks in bursts	0.5	0.6	1.6	-0.7	-0.8	-0.8	1.2	0.2	1.3	-0.2	-0.5	0.4	0.5	1.2
Cd content in liver	3.8	4.1	7.4	2.4	2.4	2.4	-2.4	-2.7	-2.4	2.2	1.3	0.9	1.1	-0.9
Co content in liver	1.2	1.4	3.3	0.8	1.0	0.9	-1.4	-1.4	-1.7	-0.0	-0.7	-1.8	-1.4	0.5
Cu content in liver	0.7	0.9	2.4	-1.0	-0.9	-0.9	0.3	0.8	0.2	-1.5	-0.7	-0.9	-1.5	0.8
Fe content in liver	2.9	3.5	7.5	1.5	1.3	1.3	-1.7	-2.1	-1.3	2.3	2.4	2.7	2.3	-0.4
K content in liver	1.9	1.9	3.7	-1.7	-1.6	-1.7	0.9	1.2	1.1	-1.6	-0.1	-0.9	-1.1	1.9
Mg content in liver	0.7	0.7	5.2	-0.5	-0.6	-0.7	-0.0	-0.3	0.3	-0.4	1.0	0.1	-0.1	2.3
Mn content in liver	2.5	2.8	5.6	-1.8	-2.0	-2.0	2.0	1.6	2.4	-1.6	0.2	0.7	0.7	2.0
Na content in liver	0.7	0.8	3.3	-0.6	-0.5	-0.6	0.6	-0.3	0.4	-0.4	-1.1	-1.0	-1.1	1.8
Rb content in liver	0.5	0.6	2.5	0.4	0.4	0.3	-0.6	-1.2	-0.6	0.5	1.2	-0.1	-0.3	1.6
Se content in liver	2.2	2.7	4.3	1.8	1.8	1.8	-2.1	-1.5	-2.0	1.2	1.4	1.3	1.1	-1.7
Sr content in liver	0.4	0.4	1.4	-0.2	-0.1	-0.2	-0.9	0.5	-0.6	0.0	0.9	-0.0	-0.3	-1.2
Zn content in liver	0.1	0.2	0.7	-0.4	-0.4	-0.4	-0.1	0.1	0.0	-0.4	0.0	-0.5	-0.3	0.8
Bone: minimum diameter	6.6	12.4	16.9	-3.7	-3.5	-3.4	3.4	4.1	3.0	-4.1	-3.5	-3.9	-4.0	1.4
Time in familiar zone, hab. session 1	1.9	1.8	3.6	1.9	1.9	1.9	-1.0	-1.6	-1.2	1.1	-0.3	0.5	1.0	-1.2
Time in novel zone, hab. session 1	0.9	0.9	2.1	-1.4	-1.4	-1.4	0.4	1.1	0.6	-0.7	0.7	-0.2	-0.8	0.8
Total zone transitions, hab. session 1	1.4	1.9	3.5	1.7	1.7	1.7	-1.4	-1.2	-1.4	1.4	0.6	0.4	1.1	-1.9
Total locomotion distance, hab. session 1	0.3	0.4	0.7	-0.8	-0.8	-0.7	0.8	0.8	0.9	-0.3	-0.6	-0.6	-0.3	0.2
Locomotion velocity, hab. session 1	0.4	0.5	0.9	-0.7	-0.7	-0.7	0.9	0.9	0.9	-0.5	-0.8	-0.7	-0.4	0.0
Time in familiar zone, hab. session 2	1.6	1.6	3.4	1.8	1.8	1.8	-0.9	-1.4	-1.1	1.0	-0.4	0.5	1.2	-1.1
Time in novel zone, hab. session 2	2.1	2.1	4.7	-2.1	-2.1	-2.2	1.0	1.6	1.3	-1.0	0.9	-0.2	-1.0	1.2
Total zone transitions, hab. session 2	2.0	2.6	4.1	2.0	2.0	2.0	-1.9	-1.9	-2.0	1.6	0.7	0.4	0.9	-1.2
Total locomotion distance, hab. session 2	0.9	1.1	1.7	1.3	1.3	1.2	-1.2	-1.2	-1.2	1.3	0.6	0.4	0.7	-0.9
Locomotion velocity, hab. session 2	1.0	1.3	2.0	1.4	1.4	1.4	-1.2	-1.3	-1.2	1.4	0.6	0.5	0.8	-1.0
Novel to familiar place preference ratio	0.7	0.7	1.2	-1.0	-1.0	-1.0	1.1	1.1	1.1	-0.9	-0.4	-0.3	-0.6	0.3
Novelty place preference	0.8	0.8	1.3	-1.1	-1.1	-1.1	1.1	1.1	1.1	-0.8	-0.2	-0.3	-0.5	0.4
Time in novel zone, NPP test	0.7	0.8	1.4	-1.1	-1.2	-1.2	1.0	1.1	1.1	-0.7	0.0	-0.1	-0.4	0.4
Total zone transitions, NPP test	1.1	1.6	2.8	1.4	1.4	1.4	-1.1	-1.6	-1.0	1.7	1.0	1.0	1.3	-0.7
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.2	-0.3	-0.3	0.2	0.1	0.4	0.3	0.4	0.4	0.4	0.1
Locomotion velocity, NPP test	0.0	0.0	0.2	0.2	0.1	0.2	-0.0	-0.2	0.0	0.4	0.1	0.1	0.2	-0.1
Intraocular pressure	0.2	0.3	0.7	0.5	0.6	0.6	-0.7	-0.3	-0.9	-0.0	-0.6	-0.6	-0.6	-0.8
Delta distance traveled before/after self-admin	0.4	0.5	1.4	0.6	0.5	0.5	-0.3	-0.3	-0.1	0.8	0.5	1.2	1.0	-0.9
Delta ambulatory time before/after self-admin	0.4	0.4	1.4	0.6	0.5	0.5	0.1	-0.1	0.2	0.6	0.2	1.1	1.2	-1.0
Parametrial fat weight	0.8	1.6	4.4	-1.2	-1.3	-1.3	2.0	1.4	2.1	-0.8	-1.0	-0.2	0.4	0.4
Pavlov. Cond. lever latency	3.3	4.2	5.5	2.2	2.2	2.2	-2.3	-2.2	-2.2	1.8	1.9	2.3	1.8	-1.3
Pavlov. Cond. magazine entry latency	4.6	5.9	10.0	-2.6	-2.7	-2.7	3.2	2.1	3.1	-2.0	-2.3	-1.5	-1.4	2.5
Pavlov. Cond. change in total contacts	3.0	3.2	4.7	-1.8	-1.7	-1.7	1.8	1.3	1.6	-1.8	-2.2	-2.1	-1.7	1.9
Pavlov. Cond. index score	3.9	4.9	7.1	-2.3	-2.3	-2.3	2.7	2.0	2.6	-1.9	-2.3	-2.1	-1.7	2.0
Pavlov. Cond. latency score	3.3	4.2	6.0	-2.1	-2.1	-2.1	2.4	1.9	2.3	-1.9	-2.1	-2.0	-1.6	1.7
Pavlov. Cond. lever contacts	2.4	2.9	4.9	-1.7	-1.6	-1.6	1.7	1.7	1.5	-1.7	-2.0	-2.2	-1.8	1.0
Pavlov. Cond. magazine entry number	4.3	5.4	9.1	2.5	2.5	2.5	-3.0	-1.7	-3.0	1.8	2.2	1.4	1.2	-2.9
Pavlov. Cond. intertrial magazine entries	0.5	0.5	1.0	0.9	1.0	1.0	-0.6	-0.7	-0.9	0.1	-0.9	0.1	-0.3	-0.8
Pavlov. Cond. lever-magazine prob. diff.	4.4	5.4	7.1	-2.5	-2.5	-2.5	2.7	2.2	2.6	-2.0	-2.3	-2.3	-1.9	2.1
Pavlov. Cond. response bias	5.8	7.0	10.6	-3.0	-3.0	-3.0	3.2	2.4	3.3	-2.2	-2.3	-2.0	-1.7	2.6
Pavlov. Cond. lever latency	0.5	0.7	1.4	0.9	0.9	0.9	-0.7	-0.6	-0.7	0.8	0.6	0.6	0.8	-1.2
Pavlov. Cond. magazine entry latency	0.5	0.6	1.1	0.8	0.8	0.8	-1.0	-0.9	-1.0	0.8	0.8	0.3	0.5	-0.6
Pavlov. Cond. change in total contacts	0.8	1.2	3.3	-0.6	-0.4	-0.5	0.2	-0.1	-0.1	-1.2	-1.5	-1.6	-1.8	1.5
Pavlov. Cond. index score	0.2	0.3	0.9	-0.5	-0.4	-0.5	0.0	0.3	-0.0	-0.7	-0.2	-0.8	-0.9	0.6
Pavlov. Cond. latency score	0.3	0.4	0.9	-0.6	-0.6	-0.6	0.2	0.4	0.1	-0.8	-0.4	-0.9	-1.0	0.6
Pavlov. Cond. lever contacts	0.4	0.6	0.9	-0.9	-0.9	-0.9	0.7	0.7	0.8	-0.9	-0.3	-0.3	-0.5	0.9
Pavlov. Cond. magazine entry number	0.4	0.5	1.2	-0.6	-0.6	-0.5	0.9	0.6	0.7	-0.7	-1.1	-0.7	-0.6	0.4
Pavlov. Cond. intertrial magazine entries	4.0	5.2	8.9	-2.2	-2.1	-2.1	2.4	2.2	2.1	-2.5	-3.0	-2.5	-2.4	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.7	-0.4	-0.3	-0.3	-0.1	0.2	-0.1	-0.5	-0.2	-0.7	-0.8	0.5
Pavlov. Cond. response bias	0.1	0.2	0.5	-0.5	-0.5	-0.5	0.4	0.3	0.4	-0.4	0.1	0.1	-0.2	0.7
Time in closed arm before self-admin	1.3	1.5	5.1	0.9	0.7	0.7	-0.5	-1.0	-0.2	1.0	1.5	2.2	2.3	0.2
Time in closed arm after self-admin	5.7	5.8	15.4	2.3	2.0	2.1	-1.1	-1.9	-0.7	2.8	2.2	3.7	3.9	-1.8
Time in open arm before self-admin	0.8	0.9	4.0	0.5	0.6	0.6	-1.3	0.1	-1.3	0.6	0.9	-0.1	-0.5	-2.0
Time in open arm after self-admin	1.7	1.9	7.8	-0.5	-0.2	-0.2	-0.2	0.7	-0.7	-1.5	-1.6	-2.8	-2.6	-0.4
Bone: periosteal estimation	5.3	10.9	15.0	-3.8	-3.7	-3.7	3.4	3.9	3.2	-3.4	-2.6	-2.8	-3.5	1.7
Bone: periosteal perimeter	4.3	7.1	10.7	-3.0	-2.9	-2.9	2.4	3.3	2.2	-3.0	-2.1	-2.7	-3.1	0.9
Bone: post-yield work	1.1	1.5	4.1	-0.7	-0.5	-0.5	0.5	1.5	0.2	-1.2	-1.4	-2.0	-1.9	-1.1
Progressive ratio test 1 active lever presses	1.2	1.2	3.3	-0.8	-0.7	-0.7	0.7	0.6	0.4	-1.3	-1.5	-1.8	-1.7	0.8
Progressive ratio test 1 breakpoint	1.6	1.6	4.7	-0.9	-0.8	-0.8	0.8	0.7	0.4	-1.5	-1.7	-2.2	-1.9	1.0
Progressive ratio test 1 inactive lever presses	3.5	3.9	5.7	-1.8	-1.8	-1.8	2.3	1.7	2.0	-2.3	-2.4	-2.2	-1.4	1.8
Progressive ratio test 2 active lever presses	0.6	0.7	2.3	-0.4	-0.4	-0.4	0.7	0.4	0.5	-0.6	-1.5	-1.4	-1.3	0.3
Progressive ratio test 2 breakpoint	0.7	0.8	2.9	-0.4	-0.4	-0.4	0.8	0.4	0.6	-0.5	-1.7	-1.4	-1.2	0.4
Progressive ratio test 2 inactive lever presses	1.8	2.1	4.4	-1.2	-1.1	-1.1	1.6	1.6	1.4	-1.9	-2.1	-1.6	-1.1	0.4
Incentive Sensitization - Responses	0.9	1.0	2.3	-0.8	-0.7	-0.7	1.0	0.6	0.8	-0.5	-1.4	-1.2	-1.5	0.9
Incentive Sensitization - Breakpoint	0.8	0.8	2.0	-0.7	-0.7	-0.7	1.0	0.5	0.8	-0.3	-1.3	-1.1	-1.4	1.0
Sum of active levers in priming session hrs 5-6	0.9	0.8	2.5	0.7	0.8	0.7	-1.1	-1.6	-1.3	0.7	0.1	-0.6	-0.8	0.9
Progressive ratio	0.1	0.1	0.4	0.2	0.2	0.2	0.3	-0.4	0.2	0.6	-0.2	0.0	0.0	0.6
Food seeking constrained by brief footshock	0.3	0.4	2.0	0.4	0.5	0.5	0.2	-0.4	-0.1	-0.3	-1.4	-1.0	-0.5	-0.1
Seeking ratio, punishment vs. effort	0.2	0.2	0.8	-0.0	0.0	0.0	-0.2	0.2	-0.2	-0.9	-0.7	-0.8	-0.6	-0.5
Retroperitoneal fat weight	0.2	0.8	1.8	-0.6	-0.6	-0.6	1.3	1.3	1.3	-1.0	-0.9	0.0	0.5	-0.7
Reaction time number correct	0.1	0.1	0.2	-0.2	-0.2	-0.2	-0.3	0.4	-0.2	-0.4	0.3	0.0	0.3	-0.4
Reaction time mean minus median	0.2	0.3	0.8	-0.5	-0.4	-0.5	0.4	0.5	0.3	-0.9	-0.8	-0.6	-0.7	0.3
Reaction time mean minus median AUC	0.3	0.3	1.2	-0.6	-0.7	-0.7	0.5	0.3	0.6	-0.6	-0.2	-0.1	-0.2	1.1
Reaction time num false alarms	0.6	0.9	1.6	-0.9	-0.8	-0.8	0.8	1.2	0.7	-1.3	-1.0	-1.1	-1.0	0.2
Reaction time num false alarms AUC	0.9	1.3	2.0	-1.1	-1.0	-1.0	1.2	1.3	1.0	-1.4	-1.2	-1.2	-1.1	0.5
Reaction time trials correct on left	0.1	0.1	0.2	-0.2	-0.2	-0.2	-0.3	0.4	-0.2	-0.4	0.3	0.0	0.3	-0.4
Reaction time trials on left	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.2	0.5	-0.1	-0.5	0.3	-0.1	0.2	-0.2
Reaction time mean	0.5	0.7	1.8	-0.8	-0.8	-0.9	0.6	0.4	0.6	-1.1	-0.5	-0.6	-0.9	1.4
Reaction time mean AUC	0.3	0.5	1.8	-0.7	-0.6	-0.7	0.4	0.2	0.4	-0.9	-0.4	-0.5	-0.7	1.4
Median of all reaction times	0.7	0.9	2.4	-1.0	-1.0	-1.1	0.7	0.6	0.7	-1.2	-0.5	-0.7	-1.1	1.6
Reaction time omissions	4.6	6.3	9.7	-2.9	-3.0	-3.0	2.7	2.3	2.8	-2.4	-1.5	-1.5	-1.7	3.1
Reaction time false alarm rate	0.6	0.9	1.5	-0.8	-0.8	-0.8	1.1	0.9	0.9	-0.9	-1.2	-1.0	-1.1	0.6
Reaction time premature initiation rate	0.7	0.9	2.0	-0.8	-0.9	-0.8	1.4	1.0	1.3	-0.8	-1.4	-0.6	-0.4	0.2
Reaction time premature initiations	0.6	0.9	2.0	-0.9	-0.9	-0.8	1.3	1.1	1.2	-0.9	-1.4	-0.6	-0.2	0.1
Std. dev. reaction times	0.3	0.5	1.5	-0.7	-0.7	-0.8	0.6	0.3	0.7	-0.8	-0.5	-0.3	-0.5	1.2
Reaction time trials completed	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.2	0.5	-0.1	-0.5	0.3	-0.1	0.2	-0.2
Reaction time trials AUC	0.0	0.1	0.2	-0.2	-0.2	-0.2	-0.2	0.4	-0.2	-0.4	0.3	-0.1	0.2	-0.2
Run reversals in cocaine runway, females	0.5	0.5	2.9	0.4	0.4	0.4	-0.8	0.2	-0.7	0.9	0.5	0.4	-0.1	-1.7
Run reversals in cocaine runway, males	1.0	1.0	2.4	-1.2	-1.2	-1.2	1.2	1.5	1.2	-1.0	-0.5	-0.2	-0.6	0.4
Latency to leave start box in cocaine runway	0.9	0.9	1.5	1.1	1.1	1.1	-0.9	-1.0	-0.9	1.2	0.8	0.6	0.9	-0.8
Latency to leave start box in cocaine runway, F	1.8	1.9	3.1	1.5	1.5	1.5	-1.6	-1.2	-1.6	1.8	1.1	0.7	0.8	-1.7
Latency to leave start box in cocaine runway, M	0.3	0.2	1.4	-0.1	-0.2	-0.2	0.6	-0.1	0.6	-0.2	0.1	0.1	0.6	1.2
Std. dev. time between licks in bursts	0.5	0.6	1.2	1.0	1.0	1.0	-0.9	-0.8	-1.1	0.6	-0.0	-0.2	-0.1	-1.0
Total sessions with >9 infusions	0.2	0.2	0.8	0.1	0.1	0.2	0.1	-0.0	-0.1	-0.7	-0.9	-0.9	-0.6	-0.0
Short access day 1 total inactive lever presses	0.9	1.1	2.1	-1.3	-1.2	-1.2	0.7	1.3	0.7	-1.4	-0.6	-0.8	-0.9	0.5
Short access day 10 total inactive lever presses	2.7	3.0	6.2	-1.7	-1.7	-1.6	2.0	2.4	1.9	-2.5	-1.8	-1.2	-0.7	-0.0
Short access day 1 total infusions	1.2	1.3	3.8	-1.0	-0.9	-0.9	1.0	0.9	0.8	-1.9	-1.3	-1.3	-0.9	1.0
Short access day 10 total infusions	1.8	2.0	3.7	-1.3	-1.2	-1.1	1.3	1.3	1.0	-1.7	-1.9	-1.9	-1.7	0.8
Short access total infusions	2.1	2.4	4.9	-1.4	-1.3	-1.3	1.4	1.4	1.2	-2.2	-1.8	-1.9	-1.3	1.1
Short access day 1 locomotion	2.1	2.2	3.8	-1.5	-1.4	-1.4	1.6	1.5	1.4	-1.6	-2.0	-1.5	-1.2	1.2
Short access day 10 total locomotion	4.7	5.3	18.0	-1.4	-1.2	-1.2	2.3	2.1	1.6	-2.3	-4.2	-3.3	-2.7	0.3
Short access total locomotion	3.5	3.7	10.7	-1.2	-1.0	-1.0	1.5	1.7	0.9	-2.2	-3.3	-3.0	-2.5	0.3
One hour access (0.3 mA shock)	0.2	0.2	0.5	0.5	0.5	0.5	-0.1	-0.3	-0.3	0.7	-0.5	-0.4	-0.1	-0.5
Compulsive drug intake	1.1	1.1	2.8	0.7	0.6	0.6	-0.8	-0.6	-0.5	1.4	1.7	1.6	1.5	-0.6
One hour access (shock baseline)	0.5	0.5	1.9	0.3	0.4	0.5	-0.0	0.1	-0.3	-0.3	-1.4	-1.2	-0.9	-0.9
Social response proportion	0.7	0.7	3.2	0.0	0.2	0.2	-0.7	1.1	-0.7	-1.4	-0.1	-0.5	-0.5	-1.8
Social responses	0.2	0.3	0.9	-0.4	-0.4	-0.4	0.5	0.9	0.5	-0.9	-0.6	-0.2	-0.1	-0.3
Social time	1.4	1.9	6.0	-1.1	-0.9	-0.9	0.2	2.0	0.1	-2.5	-0.8	-1.8	-1.8	-0.9
Soleus weight	0.1	0.3	1.2	0.0	0.1	0.1	-0.6	0.5	-0.6	-0.5	0.1	-0.5	-0.7	-1.1
Bone: stiffness	0.1	0.1	0.3	0.1	0.0	0.1	0.6	-0.0	0.5	0.2	-0.4	0.2	0.2	-0.3
Tibialis anterior weight	0.4	1.2	2.4	1.3	1.4	1.4	-1.2	-0.7	-1.5	-0.1	-0.6	-0.8	-0.4	-1.5
Time to tail flick, vehicle, before self-admin	0.7	0.7	2.9	0.2	0.1	0.1	-0.9	-0.8	-0.6	1.5	1.7	0.8	0.3	0.1
Time to tail flick, vehicle, after self-admin	0.5	0.5	1.6	-0.4	-0.4	-0.4	0.9	0.2	0.7	-0.7	-1.3	-0.7	-0.5	0.8
Time to tail flick, test, before self-admin	2.7	2.7	4.7	1.8	1.9	1.8	-2.2	-1.5	-2.1	1.3	1.2	0.6	0.5	-2.0
Time to tail flick, test, after self-admin	0.2	0.2	0.4	-0.5	-0.4	-0.4	-0.0	0.2	-0.0	-0.5	-0.2	-0.6	-0.5	0.5
Delta time to tail flick, vehicle, before/after SA	2.5	2.5	6.8	-1.1	-1.1	-1.0	1.9	1.1	1.5	-2.0	-2.6	-1.7	-1.1	1.3
Delta time to tail flick, test, before/after SA	3.0	2.7	5.1	-1.8	-1.8	-1.8	1.6	1.3	1.5	-1.7	-1.2	-1.5	-1.4	2.3
Tibia length	0.6	1.8	7.2	0.6	0.4	0.5	0.2	0.3	0.5	1.0	1.3	2.1	2.7	-2.0
Ambulatory time before self-admin	0.4	0.5	1.5	-0.5	-0.4	-0.4	0.1	0.3	-0.0	-0.6	-0.9	-1.2	-1.2	0.4
Ambulatory time after self-admin	0.1	0.1	0.4	-0.3	-0.3	-0.2	0.3	0.5	0.2	-0.3	-0.6	-0.3	-0.2	-0.4
Bone: tissue strength	1.2	1.2	3.3	1.0	0.8	0.9	-0.2	-0.6	-0.1	1.1	0.6	1.8	1.7	-1.5
Total heroin consumption	1.2	1.4	3.1	-1.3	-1.2	-1.2	0.6	0.7	0.5	-1.2	-0.7	-1.3	-1.8	1.7
Bone: trabecular number	5.1	7.9	12.1	-3.4	-3.5	-3.4	3.3	3.3	3.5	-2.7	-1.4	-1.4	-1.3	2.2
Bone: trabecular spacing	2.8	3.6	6.4	2.5	2.5	2.5	-1.9	-2.3	-2.2	1.7	0.2	0.8	0.9	-1.6
Bone: trabecular thickness	2.7	3.3	6.1	-2.3	-2.3	-2.3	1.9	2.5	2.0	-1.8	-0.6	-1.0	-1.2	0.6
Bone: trabecular tissue density	0.4	0.6	2.8	0.1	0.0	0.0	0.1	-0.3	0.4	0.9	0.8	1.7	1.3	-0.1
Water consumed over 24 hours	0.5	0.6	1.7	-0.0	-0.1	-0.1	-0.2	0.5	0.1	-0.1	1.3	1.3	1.2	-0.9
Number of responses in last shaping day	1.8	1.9	3.4	-1.3	-1.2	-1.1	1.1	1.8	1.0	-1.8	-1.6	-1.5	-1.5	-0.4