Arhgap23

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	intron excision ratio	chr10_82980881_82981283	0.04	0.03	5.1e-03	0.04	0.03	0.03	0.03	4.6e-04	3.1e-03	1.3e-03	9.6e-04
2	pVTA	gene expression	Arhgap23	0.04	0.03	1.0e-02	-0	0.01	0.01	0	5.3e-01	4.8e-02	9.4e-02	1.2e-01
3	pVTA	intron excision ratio	chr10_82980881_82982716	0.04	0.03	3.3e-03	0.04	0.03	0.02	0.03	8.1e-04	2.2e-03	9.3e-03	1.4e-03
4	Adipose	mRNA stability	Arhgap23	0.06	0.04	1.6e-07	0.06	0.05	0.05	0.05	7.6e-07	1.4e-06	1.2e-06	1.1e-06
5	BLA	gene expression	Arhgap23	0.09	0.07	3.7e-03	0.01	0.01	0.02	0.01	1.4e-01	9.2e-02	3.1e-02	1.5e-01
6	Adipose	gene expression	Arhgap23	0.11	0.1	4.0e-07	0.06	0.05	0.06	0.06	8.0e-07	1.3e-06	2.5e-07	5.0e-07
7	PL	gene expression	Arhgap23	0.02	0.02	8.8e-03	0.02	0.02	0.01	0.01	3.3e-03	6.5e-03	4.6e-02	9.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	1.0	1.8	3.9	-2.0	-0.4	1.6	1.7	0.0	-1.0	-1.5
Area under the delay curve	1.0	1.5	2.2	-1.1	-1.4	1.0	1.2	-1.2	-1.5	-1.1
BMI with tail	5.1	17.8	41.5	2.7	6.1	-2.5	-2.4	6.4	4.6	2.3
BMI without tail	1.0	5.3	6.8	2.4	2.6	-2.2	-1.9	2.5	2.3	2.1
Body weight	7.4	32.5	37.0	5.7	6.1	-5.6	-5.6	5.9	5.7	5.4
Weight adjusted by age	0.0	0.1	0.3	0.4	-0.2	-0.5	-0.4	-0.2	0.0	0.5
Bone surface	0.1	0.3	0.9	-0.0	0.8	-0.1	-0.1	0.9	0.6	0.3
Bone volume	0.2	0.4	1.4	-0.5	0.9	0.2	0.2	1.2	0.4	-0.0
Breakpoint value in progressive ratio session	0.8	1.4	2.7	1.6	0.1	-1.5	-1.3	-0.3	0.8	1.6
Number of licking bursts	0.2	0.8	0.9	-0.9	-0.9	0.9	0.7	-0.9	-0.9	-0.8
Context. condit. distance diff. score	0.5	0.6	0.9	0.8	0.9	-0.8	-0.5	0.8	0.8	0.6
Locomotion velocity, session 1	1.5	1.7	2.3	1.0	1.5	-1.2	-1.3	1.4	1.5	1.2
Locomotion distance, session 1	2.6	3.4	5.7	2.4	0.9	-2.3	-2.3	0.5	1.4	2.1
Locomotion velocity, session 2	0.5	0.6	1.2	0.8	0.4	-1.1	-1.1	0.1	0.6	1.0
Locomotion distance, session 2	0.7	0.9	1.7	1.3	-0.1	-1.3	-1.3	-0.5	0.3	1.1
Locomotion velocity, session 3	0.1	0.1	0.3	0.4	0.3	-0.2	-0.5	0.2	0.3	0.5
Locomotion distance, session 3	0.3	0.4	0.7	0.8	-0.3	-0.7	-0.8	-0.6	-0.0	0.6
Stereotopy head waving bouts, day 3	2.2	2.6	5.2	-2.2	-0.5	2.3	2.0	-0.0	-1.1	-1.8
Stereotopy head waving duration, day 3	0.4	0.5	1.1	-1.0	0.4	1.1	0.8	0.7	-0.1	-0.6
Locomotion velocity, session 7	0.3	0.4	1.0	1.0	-0.1	-0.8	-0.6	-0.4	0.1	0.6
Locomotion distance, session 7	0.7	0.9	3.1	0.3	-1.4	-0.3	0.1	-1.7	-1.0	-0.1
Stereotopy head waving bouts, day 7	0.7	0.8	1.9	-1.4	-0.5	1.3	0.9	-0.2	-0.4	-0.6
Stereotopy head waving duration, day 7	0.1	0.2	0.6	-0.8	-0.0	0.7	0.3	0.3	0.2	0.1
Locomotion velocity, session 8	6.0	7.2	8.8	3.0	2.6	-2.8	-2.7	2.4	2.7	2.7
Locomotion distance, session 8	1.3	1.8	2.9	1.7	0.9	-1.6	-1.6	0.6	1.1	1.5
Degree of sensitization distance	0.1	0.1	0.3	0.4	0.1	-0.5	-0.2	0.0	0.2	0.2
Degree of sensitization stereotypy	1.3	1.4	2.4	-1.5	-1.2	1.4	1.2	-0.9	-0.9	-0.8
Conditioned locomotion	0.2	0.2	0.3	-0.4	0.2	0.6	0.5	0.4	-0.2	-0.5
Cocaine response after cond. corrected	1.0	1.4	3.5	-1.9	0.4	1.5	1.4	0.7	-0.5	-1.3
Cocaine response after cond. not corrected	1.6	2.3	4.9	-2.2	-0.4	1.9	1.8	-0.0	-1.1	-1.6
Cocaine response before conditioning	1.6	2.0	3.6	-0.9	-1.9	1.2	1.1	-1.9	-1.6	-0.9
Saline control response	0.2	0.3	0.7	-0.1	-0.8	0.4	0.3	-0.8	-0.7	-0.3
Bone: connectivity density	1.8	2.9	4.3	-2.1	-1.3	1.9	2.0	-1.0	-1.6	-1.8
Bone: cortical apparent density	5.6	8.9	14.9	-2.8	-3.9	2.6	2.4	-3.8	-3.0	-2.1
Bone: cortical area	0.1	0.2	0.4	-0.6	-0.2	0.5	0.6	-0.1	-0.6	-0.6
Bone: cortical porosity	0.8	0.8	1.8	-1.0	-0.6	0.8	1.0	-0.5	-1.0	-1.3
Bone: cortical porosity	0.8	0.9	2.0	-0.9	-0.5	0.7	1.0	-0.5	-1.0	-1.4
Bone: cortical thickness	1.5	2.4	3.1	-1.7	-1.7	1.4	1.4	-1.5	-1.8	-1.3
Bone: cortical thickness	5.0	6.1	8.2	-2.4	-2.5	2.4	2.4	-2.4	-2.9	-2.3
Bone: cortical tissue density	5.7	9.0	15.3	-2.8	-3.9	2.6	2.4	-3.8	-3.0	-2.1
Condit. Reinf. active minus inactive responses	0.4	0.5	0.7	-0.7	-0.8	0.5	0.7	-0.8	-0.7	-0.5
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.1	-0.8	-0.6	0.8	1.0	-0.6	-0.8	-0.9
Condit. Reinf. active responses	0.5	0.6	1.0	-1.0	-0.8	0.7	0.8	-0.8	-0.7	-0.7
Condit. Reinf. inactive responses	0.4	0.5	0.9	-0.9	-0.8	0.6	0.6	-0.7	-0.7	-0.7
Incentive salience index mean	1.3	1.6	2.1	-1.2	-1.4	1.0	1.2	-1.4	-1.4	-1.2
Condit. Reinf. lever presses	1.5	2.2	3.5	-1.3	-1.9	1.0	1.3	-1.9	-1.6	-1.4
Condit. Reinf. active minus inactive responses	0.5	0.8	1.1	-0.8	-0.6	1.0	0.8	-0.7	-1.0	-1.1
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.4	-0.6	-0.2	0.6	0.5	-0.1	-0.3	-0.6
Condit. Reinf. active responses	1.1	1.5	2.1	-1.0	-1.1	1.4	1.2	-1.1	-1.4	-1.4
Condit. Reinf. inactive responses	2.0	3.0	4.2	-1.4	-1.8	1.7	1.6	-1.8	-2.0	-1.7
Condit. Reinf. lever presses	0.2	0.3	0.7	-0.1	-0.7	0.4	0.1	-0.8	-0.7	-0.3
Condit. Reinf. lever reinforcers received	1.2	1.7	2.4	-1.0	-1.3	1.3	1.1	-1.3	-1.5	-1.4
Conditioned reinforcement - actives	0.3	1.1	1.9	-1.0	-0.6	1.2	1.4	-0.5	-1.1	-1.4
Conditioned reinforcement - inactives	0.1	0.4	0.8	0.0	-0.7	0.1	0.5	-0.9	-0.7	-0.7
Conditioned locomotion	0.9	1.3	2.7	-1.2	0.1	1.2	1.6	0.3	-1.0	-1.7
Patch foraging indifference point 0 sec	0.6	1.6	2.7	-1.5	-0.5	1.7	1.4	-0.3	-1.2	-1.5
Patch foraging indifference point AUC	0.1	0.2	0.5	-0.1	-0.1	-0.3	-0.5	0.1	0.5	0.7
Delay disc. indifference point, 0s delay	2.5	2.8	4.5	-1.4	-2.1	1.2	1.4	-1.9	-1.9	-1.4
Delay disc. indifference point, 16s delay	0.3	0.4	0.8	-0.9	-0.3	0.8	0.8	0.0	-0.6	-0.4
Delay disc. indifference point, 2s delay	3.1	3.4	4.8	-1.9	-2.0	1.5	1.7	-1.7	-2.2	-1.9
Delay disc. indifference point, 24s delay	0.0	0.1	0.2	-0.3	-0.2	0.2	-0.0	-0.0	0.1	0.5
Delay disc. indifference point, 4s delay	1.5	1.6	3.5	-0.8	-1.9	0.4	0.8	-1.8	-1.6	-0.7
Delay disc. indifference point, 8s delay	0.6	1.0	1.4	-0.7	-1.0	0.7	1.2	-1.0	-1.1	-1.1
Indifference point function ln k	0.0	0.1	0.2	0.1	-0.0	0.3	0.3	-0.2	-0.4	-0.2
Indifference point function log k	0.0	0.1	0.2	0.1	-0.0	0.3	0.3	-0.2	-0.4	-0.2
Patch foraging total patch changes 0 sec	0.3	0.9	1.7	-1.2	-0.2	1.3	1.1	0.0	-0.8	-1.1
Patch foraging total patch changes 12 sec	3.0	4.0	6.1	-2.5	-1.6	2.3	2.1	-1.3	-1.9	-2.1
Patch foraging total patch changes 18 sec	0.1	0.2	0.7	-0.8	0.3	0.3	0.1	0.8	0.3	-0.1
Patch foraging total patch changes 24 sec	0.3	0.9	2.8	-1.7	-0.4	1.1	1.0	-0.0	-0.5	-0.9
Patch foraging total patch changes 6 sec	0.4	0.7	1.7	-1.3	-0.3	1.1	0.8	0.0	-0.4	-0.9
Patch foraging time to switch 0 sec	0.0	0.0	0.2	-0.1	0.1	0.0	0.2	0.0	-0.1	-0.5
Patch foraging water rate 0 sec	0.0	0.2	0.7	-0.0	0.5	0.3	0.0	0.8	0.3	0.4
Patch foraging water rate 12 sec	0.1	0.3	0.6	0.6	0.3	-0.7	-0.8	0.1	0.4	0.7
Patch foraging water rate 18 sec	0.7	1.5	2.5	-0.7	-1.5	0.8	1.1	-1.6	-1.5	-1.0
Patch foraging water rate 24 sec	0.2	0.3	0.5	-0.4	-0.2	0.7	0.6	-0.0	-0.5	-0.6
Patch foraging water rate 6 sec	0.8	1.2	1.6	-1.1	-1.3	1.1	1.1	-1.1	-1.2	-0.8
Seeking ratio, delayed vs. immediate footshock	0.4	0.6	1.0	0.7	1.0	-0.5	-0.6	1.0	0.8	0.8
Distance traveled before self-admin	0.1	0.1	0.8	0.9	0.2	-0.4	-0.1	-0.0	-0.1	-0.0
Distance traveled after self-admin	0.7	1.2	2.1	1.2	1.4	-0.8	-0.6	1.4	1.1	0.8
Extensor digitorum longus weight	7.7	30.7	33.2	5.7	5.2	-5.8	-5.8	4.9	5.7	5.7
Bone: elastic displacement	0.0	0.0	0.1	-0.1	0.3	0.1	0.0	0.2	0.1	-0.3
Bone: elastic work	0.0	0.0	0.0	-0.1	0.2	-0.0	-0.1	0.1	-0.0	-0.0
Bone: endosteal estimation	1.6	4.0	5.4	2.1	2.3	-1.9	-1.8	2.1	2.0	1.6
Bone: endosteal perimeter	1.7	4.2	5.7	2.1	2.4	-2.0	-1.8	2.2	2.1	1.6
Epididymis fat weight	0.1	0.3	0.8	0.2	0.8	-0.2	-0.3	0.9	0.6	0.4
Delta time in closed arm before/after self-admin	4.0	3.8	4.8	2.2	1.8	-1.8	-1.9	1.6	2.1	2.1
Delta time in open arm before/after self-admin	0.3	0.4	1.1	-0.2	-1.0	-0.1	0.0	-1.1	-0.5	-0.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	0.5	-0.4	-0.2	-0.1	-0.6	-0.0	0.1
Delay discount exponential model param	0.8	1.0	1.6	0.8	1.3	-0.7	-1.0	1.1	1.3	0.9
Extinction: sum of active levers before priming	0.3	0.5	1.6	0.8	0.2	-0.5	-0.6	0.2	0.7	1.2
Active lever presses in extinction session 6	0.1	0.1	0.4	0.1	0.2	0.2	0.1	0.3	0.6	0.4
Bone: final force	0.9	1.5	2.3	-1.5	-0.8	1.4	1.4	-0.5	-1.3	-1.3
Bone: final moment	0.8	1.3	1.9	-1.4	-0.7	1.3	1.3	-0.5	-1.3	-1.4
Food consumed during 24 hour testing period	0.4	0.8	1.6	0.9	0.3	-0.8	-1.3	0.1	0.8	1.2
Glucose	0.3	0.5	1.1	-1.0	0.1	0.9	0.7	0.4	-0.5	-0.7
Heart weight	3.9	6.2	7.7	2.5	2.8	-2.4	-2.2	2.7	2.7	2.1
Delay discount hyperbolic model param	0.8	1.0	1.6	0.8	1.3	-0.7	-0.9	1.1	1.3	0.8
Intermittent access intake day 1-15 change	0.1	0.3	0.8	0.5	0.8	-0.3	-0.1	0.9	0.8	0.2
Intermittent access intake escalation	0.0	0.2	0.5	0.5	0.6	-0.2	-0.1	0.7	0.7	0.2
Intermittent access intake escalation 2	0.9	1.5	2.9	0.9	1.5	-0.7	-0.8	1.7	1.6	1.0
Intermitt. access day 1 inactive lever presses	0.1	1.1	2.1	-0.6	-1.3	0.7	0.9	-1.4	-1.2	-0.9
Intermitt. access day 15 inactive lever presses	0.1	0.4	0.8	-0.7	-0.1	0.7	0.8	-0.0	-0.2	-0.9
Intermitt. access escalation Index	0.6	1.8	2.9	1.0	1.7	-0.9	-1.4	1.7	1.3	1.1
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.0	-0.2	0.1	0.2	-0.2	-0.4	0.1
Intermittent access day 15 total infusions	0.0	0.1	0.2	0.4	0.2	-0.1	-0.0	0.3	0.3	0.3
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.1	0.1	0.2	0.2	0.3	0.3	0.0
Intermittent access total infusions	0.0	0.0	0.1	0.2	0.2	-0.2	-0.1	0.2	0.2	0.4
Intermittent access day 1 locomotion	0.2	0.3	0.8	-0.3	-0.6	0.3	0.6	-0.7	-0.9	-0.5
Intermittent access day 15 total locomotion	0.2	0.6	1.4	-0.6	-0.5	1.0	1.2	-0.4	-0.7	-0.8
Intermittent access total locomotion	0.9	1.1	2.0	-0.9	-0.6	1.1	1.4	-0.6	-1.0	-1.4
Intermittent access standard deviation	0.0	0.2	0.6	-0.2	0.5	0.2	0.4	0.8	0.4	-0.2
Left kidney weight	0.7	5.3	6.1	2.4	2.3	-2.3	-2.5	2.1	2.1	2.5
Right kidney weight	0.2	1.3	2.8	0.7	1.5	-0.6	-1.0	1.7	1.0	0.9
Cocaine induced anxiety	1.8	4.9	5.9	2.4	2.1	-2.1	-2.1	2.0	2.4	2.3
Post-drug Anxiety	0.6	0.7	1.3	1.1	0.7	-0.9	-0.8	0.6	1.0	0.8
Baseline Anxiety	2.8	4.7	5.5	-2.1	-2.3	2.0	1.9	-2.3	-2.3	-2.2
Tail length	0.9	5.1	7.3	2.6	-1.7	-2.5	-2.5	-2.5	-0.2	2.7
Length with tail	2.8	12.5	20.4	4.5	1.4	-4.3	-4.5	0.8	2.5	4.4
Length without tail	2.0	10.4	12.3	3.2	3.3	-3.1	-3.5	3.2	3.2	3.0
Times rat made contact with spout	0.7	0.8	1.2	-1.1	-0.8	1.1	0.7	-0.8	-0.8	-0.8
Lifetime Intake	0.0	0.0	0.0	0.1	0.0	-0.1	0.1	0.1	0.0	0.2
Liver weight, left	0.2	0.3	0.7	0.3	0.3	-0.6	-0.5	0.3	0.6	0.8
Liver weight, right	0.2	0.3	0.8	-0.9	-0.5	0.7	0.6	-0.4	-0.4	-0.1
Locomotor activity	0.3	0.5	0.9	-1.0	-0.1	0.9	1.0	0.1	-0.3	-0.6
Locomotor testing distance	1.3	3.3	5.6	-2.0	-1.1	2.2	2.4	-0.7	-1.6	-2.1
Locomotor testing rearing	1.6	5.7	7.2	-2.5	-2.4	2.7	2.7	-2.0	-2.3	-2.2
Locomotion in novel chamber	2.2	2.9	3.6	-1.8	-1.9	1.8	1.5	-1.8	-1.8	-1.2
Locomotion in novel chamber post-restriction	0.1	0.2	0.5	-0.7	0.2	0.6	0.2	0.4	0.1	-0.7
Fecal boli incidents, locomotor time 1	0.5	1.3	3.1	0.5	1.6	-0.7	-0.6	1.8	1.3	0.4
Change in fecal boli incidents, locomotor task	1.1	1.2	2.6	-0.6	-1.6	0.9	0.7	-1.6	-1.2	-0.5
Time >=10cm from walls, locomotor time 1	0.8	0.9	1.4	-0.9	-1.1	0.7	0.9	-1.2	-0.9	-1.1
Bouts of movement, locomotor time 1	0.3	0.4	0.8	0.7	0.7	-0.9	-0.5	0.4	0.3	0.4
Total resting periods, locomotor time 1	0.4	0.5	0.9	0.8	0.9	-0.9	-0.6	0.6	0.4	0.4
Rest time, locomotor task time 1	0.1	0.1	0.3	0.1	0.6	-0.3	-0.3	0.3	0.1	-0.3
Distance moved, locomotor task time 1	0.1	0.4	0.9	-0.4	-0.9	0.5	0.6	-0.9	-0.6	-0.1
Vertical activity count, locomotor time 1	0.0	0.1	0.3	0.6	-0.2	-0.2	0.1	-0.2	-0.1	0.4
Time >=10cm from walls, locomotor time 2	0.8	2.4	3.5	-1.3	-1.7	1.1	1.4	-1.9	-1.8	-1.5
Bouts of movement, locomotor time 2	0.0	0.1	0.4	-0.1	-0.2	0.1	0.6	-0.2	-0.5	-0.6
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.2	0.0	-0.2	0.4	-0.1	-0.3	-0.5
Rest time, locomotor task time 2	0.5	0.9	1.9	1.3	0.3	-1.4	-1.1	-0.2	0.8	0.7
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.0	-0.1	0.1	0.0	-0.0	-0.2	0.2
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.3	0.2	-0.0	0.1	0.2	-0.2	0.1
Light reinforcement 1	0.6	2.5	4.1	-1.6	-1.1	1.8	1.7	-1.1	-1.5	-2.0
Light reinforcement 2	0.3	0.7	1.1	-1.0	-0.6	1.0	0.9	-0.6	-0.8	-1.1
Bone: marrow area	1.5	3.7	4.8	2.1	2.2	-1.8	-1.8	2.0	1.9	1.6
Bone: maximum diameter	0.1	0.2	0.7	-0.1	0.7	0.0	0.1	0.9	0.3	-0.2
Bone: maximum force	0.1	0.1	0.4	-0.3	0.5	0.2	0.2	0.6	-0.0	-0.1
Bone: maximum moment	0.1	0.1	0.5	-0.2	0.6	0.1	0.2	0.7	-0.0	-0.2
Mean time between licks in bursts	0.4	2.5	3.7	1.7	1.6	-1.9	-1.6	1.4	1.6	1.4
Mean num. licks in bursts	0.0	0.0	0.0	0.1	-0.0	-0.1	0.0	-0.1	-0.0	0.0
Cd content in liver	0.7	0.8	1.5	1.2	0.8	-1.0	-0.7	0.5	0.9	0.8
Co content in liver	1.9	2.2	2.6	1.6	1.3	-1.5	-1.5	1.2	1.5	1.6
Cu content in liver	0.5	0.6	1.2	0.8	-0.0	-1.1	-1.1	-0.3	0.6	0.8
Fe content in liver	1.5	1.9	2.8	1.6	1.0	-1.6	-1.7	0.8	1.3	1.4
K content in liver	0.0	0.0	0.1	-0.2	0.0	-0.2	-0.1	0.0	-0.0	-0.0
Mg content in liver	0.4	0.4	1.3	-0.4	-1.1	0.1	0.0	-1.1	-0.7	-0.1
Mn content in liver	0.8	0.9	2.8	-0.2	-1.5	0.0	0.1	-1.7	-0.9	-0.4
Na content in liver	0.1	0.2	0.4	-0.5	0.5	0.3	0.2	0.6	0.2	-0.3
Rb content in liver	1.6	1.8	2.3	-1.2	-1.5	1.2	1.3	-1.5	-1.4	-1.3
Se content in liver	2.2	2.6	4.5	-2.1	-1.2	1.7	1.8	-0.9	-1.4	-1.8
Sr content in liver	0.7	0.6	1.0	1.0	0.1	-1.0	-1.0	-0.0	0.4	1.0
Zn content in liver	1.3	1.5	2.2	-1.3	-1.1	1.2	1.3	-0.9	-1.4	-1.5
Bone: minimum diameter	0.4	0.8	1.1	1.0	1.0	-0.8	-0.8	1.1	0.8	0.9
Time in familiar zone, hab. session 1	0.6	0.7	1.1	-0.6	-1.1	0.8	0.8	-1.1	-0.7	-0.6
Time in novel zone, hab. session 1	0.4	0.5	0.9	-0.9	0.4	0.8	0.7	0.6	-0.4	-0.9
Total zone transitions, hab. session 1	1.4	2.0	3.5	1.8	-0.2	-1.9	-1.8	-0.7	0.7	1.7
Total locomotion distance, hab. session 1	0.3	0.5	1.7	0.2	-1.1	-0.1	-0.1	-1.3	-0.7	-0.1
Locomotion velocity, hab. session 1	0.4	0.6	1.0	1.0	-0.6	-0.8	-0.8	-1.0	-0.1	0.6
Time in familiar zone, hab. session 2	0.5	0.6	0.9	-0.6	-0.6	0.9	1.0	-0.5	-0.6	-1.0
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.2	-0.1	0.1	0.0	-0.0	-0.3	-0.1
Total zone transitions, hab. session 2	0.4	0.5	1.1	1.0	-0.1	-1.0	-0.8	-0.4	0.3	0.7
Total locomotion distance, hab. session 2	0.0	0.1	0.2	0.5	0.1	-0.3	-0.2	-0.0	0.1	0.0
Locomotion velocity, hab. session 2	0.1	0.2	0.5	0.7	0.3	-0.5	-0.4	0.1	0.3	0.3
Novel to familiar place preference ratio	1.0	1.3	2.6	1.2	0.7	-1.2	-1.4	0.7	1.0	1.6
Novelty place preference	0.6	0.7	1.7	1.0	0.4	-0.8	-1.0	0.4	0.7	1.3
Time in novel zone, NPP test	0.2	0.2	0.6	0.5	0.1	-0.4	-0.5	0.0	0.2	0.8
Total zone transitions, NPP test	0.3	0.5	1.2	0.7	-0.8	-0.7	-0.7	-1.1	-0.3	0.4
Total locomotion distance, NPP test	0.2	0.3	0.8	-0.0	-0.7	0.1	-0.0	-0.9	-0.6	-0.3
Locomotion velocity, NPP test	0.2	0.2	0.4	0.6	-0.4	-0.6	-0.7	-0.5	-0.1	0.4
Intraocular pressure	0.8	1.4	2.7	1.6	0.6	-1.2	-1.1	0.4	1.0	1.6
Delta distance traveled before/after self-admin	0.9	1.0	1.7	0.7	1.1	-0.8	-0.7	1.3	1.1	0.9
Delta ambulatory time before/after self-admin	0.3	0.5	1.3	0.2	0.9	-0.3	-0.4	1.1	0.7	0.6
Parametrial fat weight	0.4	1.1	1.6	-1.0	-0.6	1.3	1.2	-0.6	-1.1	-1.1
Pavlov. Cond. lever latency	3.4	4.3	6.6	1.8	2.6	-1.8	-1.8	2.5	2.2	1.8
Pavlov. Cond. magazine entry latency	8.2	10.5	12.5	-3.5	-3.0	3.5	3.4	-2.6	-3.2	-3.3
Pavlov. Cond. change in total contacts	8.6	9.2	12.1	-3.2	-3.5	3.2	2.8	-3.1	-3.0	-2.4
Pavlov. Cond. index score	8.8	11.2	12.3	-3.4	-3.5	3.5	3.4	-3.1	-3.4	-3.2
Pavlov. Cond. latency score	7.0	8.9	10.3	-3.0	-3.2	3.1	2.9	-2.9	-3.0	-2.8
Pavlov. Cond. lever contacts	4.4	5.3	8.1	-1.9	-2.9	2.0	2.0	-2.8	-2.4	-2.0
Pavlov. Cond. magazine entry number	12.3	15.7	18.3	4.3	3.9	-4.2	-4.1	3.5	3.9	3.8
Pavlov. Cond. intertrial magazine entries	1.1	1.3	2.2	1.3	0.9	-1.5	-1.4	0.6	1.0	1.1
Pavlov. Cond. lever-magazine prob. diff.	10.2	12.7	13.8	-3.6	-3.7	3.7	3.6	-3.3	-3.6	-3.4
Pavlov. Cond. response bias	10.1	12.6	13.9	-3.6	-3.7	3.7	3.6	-3.4	-3.5	-3.3
Pavlov. Cond. lever latency	0.2	0.2	0.7	0.6	-0.0	-0.8	-0.5	-0.2	0.3	0.6
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.3	-0.3	-0.1	0.1
Pavlov. Cond. change in total contacts	0.2	0.5	0.8	-0.7	-0.3	0.9	0.7	-0.3	-0.7	-0.9
Pavlov. Cond. index score	0.1	0.1	0.4	-0.4	0.0	0.6	0.3	0.1	-0.3	-0.4
Pavlov. Cond. latency score	0.1	0.1	0.4	-0.3	-0.0	0.6	0.2	0.0	-0.3	-0.4
Pavlov. Cond. lever contacts	0.3	0.4	1.1	-0.8	-0.2	1.0	0.7	-0.0	-0.6	-0.8
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.4	0.3	-0.5	-0.4	0.3	0.6	0.6
Pavlov. Cond. intertrial magazine entries	0.6	1.4	2.2	1.5	0.3	-1.5	-1.5	0.0	0.9	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.2	-0.2	0.2	0.4	0.1	0.2	-0.2	-0.3
Pavlov. Cond. response bias	0.5	0.7	1.2	-1.0	-0.3	1.1	0.9	-0.1	-0.7	-1.1
Time in closed arm before self-admin	1.1	1.9	3.1	-1.7	-0.7	1.5	1.4	-0.4	-1.3	-1.8
Time in closed arm after self-admin	0.7	0.8	1.6	0.6	1.2	-0.4	-0.7	1.3	0.9	0.6
Time in open arm before self-admin	2.5	3.0	4.1	2.0	1.6	-1.7	-1.7	1.4	1.8	1.8
Time in open arm after self-admin	0.3	0.4	0.9	0.8	-0.3	-0.9	-0.7	-0.5	0.3	0.5
Bone: periosteal estimation	0.2	0.6	1.3	0.6	1.1	-0.5	-0.4	1.2	0.7	0.3
Bone: periosteal perimeter	0.7	1.4	2.3	1.1	1.5	-1.1	-0.9	1.5	1.2	0.8
Bone: post-yield work	0.6	1.0	1.4	1.1	1.2	-1.0	-0.8	1.0	0.9	0.8
Progressive ratio test 1 active lever presses	0.4	0.8	1.3	-0.9	-0.9	0.8	0.8	-0.9	-1.1	-0.7
Progressive ratio test 1 breakpoint	0.4	0.8	1.1	-0.9	-0.9	0.8	0.8	-0.8	-1.1	-0.7
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.4	-0.1	-0.3	0.3	0.5	-0.4	-0.5	-0.7
Progressive ratio test 2 active lever presses	0.4	0.5	0.7	-0.7	-0.7	0.8	0.8	-0.7	-0.7	-0.6
Progressive ratio test 2 breakpoint	0.5	0.6	0.7	-0.8	-0.8	0.8	0.9	-0.7	-0.7	-0.6
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	0.6	0.3	-0.5	-0.3	0.2	0.5	0.6
Incentive Sensitization - Responses	0.2	0.5	0.6	-0.7	-0.7	0.7	0.8	-0.6	-0.4	-0.7
Incentive Sensitization - Breakpoint	0.1	0.3	0.4	-0.6	-0.5	0.6	0.6	-0.4	-0.3	-0.5
Sum of active levers in priming session hrs 5-6	0.8	0.7	2.3	-0.2	-1.4	0.4	0.4	-1.5	-0.6	0.3
Progressive ratio	0.1	0.2	0.6	0.1	-0.6	-0.0	-0.1	-0.8	-0.3	0.0
Food seeking constrained by brief footshock	0.4	0.4	1.3	-1.2	-0.1	0.7	0.8	-0.1	-0.4	-0.6
Seeking ratio, punishment vs. effort	0.1	0.2	0.4	-0.7	0.2	0.4	0.6	0.2	0.0	-0.2
Retroperitoneal fat weight	0.1	0.6	1.1	-0.8	0.2	0.9	1.0	0.2	-0.7	-1.0
Reaction time number correct	0.2	0.6	1.3	1.0	0.5	-1.1	-1.1	0.2	0.6	0.6
Reaction time mean minus median	0.0	0.0	0.1	0.3	0.0	-0.1	-0.1	-0.1	0.1	-0.1
Reaction time mean minus median AUC	0.1	0.6	1.0	-0.5	-0.8	0.6	0.7	-0.8	-0.8	-1.0
Reaction time num false alarms	0.6	1.1	1.4	-0.9	-1.2	1.0	1.0	-1.1	-1.1	-0.8
Reaction time num false alarms AUC	0.4	0.8	1.2	-0.8	-1.1	0.9	0.9	-1.0	-1.0	-0.7
Reaction time trials correct on left	0.2	0.6	1.3	1.0	0.5	-1.1	-1.1	0.2	0.6	0.6
Reaction time trials on left	0.2	0.6	1.2	1.0	0.4	-1.0	-1.1	0.2	0.6	0.5
Reaction time mean	0.0	0.1	0.2	-0.1	0.4	-0.0	0.0	0.5	0.4	-0.1
Reaction time mean AUC	0.0	0.1	0.2	0.0	0.4	-0.1	-0.0	0.5	0.4	-0.1
Median of all reaction times	0.1	0.1	0.3	-0.5	0.3	0.3	0.3	0.5	0.2	-0.3
Reaction time omissions	0.4	0.6	0.7	-0.9	-0.6	0.8	0.8	-0.7	-0.7	-0.8
Reaction time false alarm rate	1.1	1.5	1.9	-1.3	-1.2	1.4	1.4	-0.9	-1.3	-1.0
Reaction time premature initiation rate	0.5	0.7	1.0	-0.7	-1.0	0.7	0.6	-1.0	-1.0	-1.0
Reaction time premature initiations	0.1	0.2	0.4	0.2	-0.5	-0.2	-0.3	-0.6	-0.4	-0.3
Std. dev. reaction times	0.0	0.0	0.2	-0.1	-0.1	0.2	0.1	-0.0	-0.1	-0.4
Reaction time trials completed	0.2	0.6	1.2	1.0	0.4	-1.0	-1.1	0.2	0.6	0.5
Reaction time trials AUC	0.1	0.5	1.0	0.9	0.3	-1.0	-1.0	0.1	0.5	0.4
Run reversals in cocaine runway, females	1.0	1.1	2.1	1.5	1.0	-1.1	-0.9	0.8	1.1	1.1
Run reversals in cocaine runway, males	0.1	0.1	0.5	-0.0	-0.0	0.5	0.5	0.0	-0.1	-0.7
Latency to leave start box in cocaine runway	3.1	4.2	6.5	1.8	2.6	-2.0	-1.7	2.5	2.0	1.6
Latency to leave start box in cocaine runway, F	4.0	5.0	8.1	1.9	2.9	-2.1	-1.9	2.8	2.2	1.5
Latency to leave start box in cocaine runway, M	0.7	0.7	1.1	0.7	1.0	-0.8	-0.5	0.9	0.8	1.1
Std. dev. time between licks in bursts	0.5	1.0	2.0	0.6	1.4	-0.6	-0.7	1.4	1.2	0.7
Total sessions with >9 infusions	0.0	0.0	0.1	-0.1	-0.0	0.2	0.3	0.1	-0.3	-0.2
Short access day 1 total inactive lever presses	1.6	3.3	7.4	-1.0	-2.5	1.1	1.3	-2.7	-1.9	-1.2
Short access day 10 total inactive lever presses	0.1	0.5	0.9	0.9	0.8	-0.9	-0.6	0.6	0.7	0.5
Short access day 1 total infusions	0.0	0.0	0.0	-0.1	-0.1	0.1	0.2	0.1	-0.1	-0.1
Short access day 10 total infusions	0.1	0.1	0.3	-0.5	-0.0	0.4	0.5	0.2	-0.1	-0.0
Short access total infusions	0.0	0.0	0.2	0.0	0.3	-0.0	-0.0	0.4	0.1	0.2
Short access day 1 locomotion	0.3	0.5	1.1	-0.9	-0.1	0.8	0.9	0.1	-0.5	-1.1
Short access day 10 total locomotion	0.6	2.5	4.0	-1.7	-0.8	1.9	2.0	-0.6	-1.5	-2.0
Short access total locomotion	0.2	0.3	0.6	-0.5	0.1	0.5	0.7	0.2	-0.4	-0.8
One hour access (0.3 mA shock)	0.1	0.1	0.3	-0.1	-0.5	0.2	0.3	-0.5	-0.3	0.0
Compulsive drug intake	0.8	1.2	3.6	-0.8	-1.6	0.5	0.4	-1.9	-1.1	-0.5
One hour access (shock baseline)	0.2	0.5	1.5	0.5	1.0	-0.2	-0.1	1.2	0.7	0.3
Social response proportion	0.2	0.3	0.8	-0.1	-0.5	-0.1	0.2	-0.8	-0.9	-0.6
Social responses	0.2	0.2	0.3	-0.4	-0.2	0.3	0.4	-0.5	-0.6	-0.6
Social time	0.0	0.0	0.2	0.0	0.2	0.0	-0.0	0.1	0.4	0.1
Soleus weight	0.3	0.9	1.8	-1.4	0.1	1.2	1.1	0.5	-0.6	-1.0
Bone: stiffness	0.0	0.1	0.1	-0.3	0.0	0.2	0.3	0.2	-0.3	-0.3
Tibialis anterior weight	1.1	3.8	5.2	2.1	1.4	-2.2	-2.3	1.2	1.9	2.3
Time to tail flick, vehicle, before self-admin	1.2	1.4	3.8	-0.5	-1.9	0.7	0.8	-1.9	-1.0	-0.3
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.3	-0.3	0.1	0.5	0.2	0.3	0.4	-0.1
Time to tail flick, test, before self-admin	0.3	0.4	0.8	0.5	0.6	-0.3	-0.6	0.6	0.9	0.7
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.4	0.1	0.3	0.2	0.2	0.2	0.0
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.7	-0.7	0.6	0.7	0.4	0.9	0.2	-0.6
Delta time to tail flick, test, before/after SA	1.5	1.8	2.6	-1.2	-1.4	1.1	1.3	-1.4	-1.6	-1.3
Tibia length	0.9	2.5	4.1	1.3	1.8	-1.3	-1.5	2.0	1.5	1.4
Ambulatory time before self-admin	0.2	0.5	1.6	1.3	0.7	-1.0	-0.6	0.5	0.4	0.4
Ambulatory time after self-admin	1.9	3.0	4.4	1.8	2.0	-1.5	-1.3	2.1	1.7	1.6
Bone: tissue strength	0.5	0.5	0.7	0.5	0.7	-0.5	-0.8	0.7	0.8	0.7
Total heroin consumption	0.5	0.6	1.5	-0.5	-1.2	0.4	0.6	-1.2	-0.7	-0.1
Bone: trabecular number	3.3	6.1	9.2	-3.0	-1.7	2.8	2.9	-1.3	-2.3	-2.7
Bone: trabecular spacing	0.6	0.8	1.5	1.2	0.6	-1.1	-1.0	0.4	0.9	0.9
Bone: trabecular thickness	0.3	0.5	1.8	-0.2	1.1	-0.0	-0.0	1.3	0.6	0.2
Bone: trabecular tissue density	0.0	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.2	-0.0	0.2
Water consumed over 24 hours	0.0	0.0	0.1	-0.0	-0.2	0.2	-0.2	-0.3	-0.1	0.1
Number of responses in last shaping day	0.2	0.2	0.5	0.2	0.5	-0.3	-0.4	0.6	0.7	0.6