Hub : Genes

Apof

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr7_1285311_1285552	0.59	0.15	0.0e+00	0.44	0.49	0.49	0.49	5.4e-53	2.8e-61	1.4e-61	4.8e-62
2	Liver	intron excision ratio	chr7_1285311_1285781	0.6	0.17	0.0e+00	0.38	0.43	0.44	0.44	7.2e-45	3.6e-52	5.3e-53	4.2e-53
3	Liver	gene expression	Apof	0.74	0.11	0.0e+00	0.54	0.63	0.63	0.64	8.3e-71	8.4e-91	3.4e-91	9.6e-92
4	Liver	intron excision ratio	chr7_1287211_1290139	0.29	0.13	0.0e+00	0.25	0.25	0.25	0.25	6.3e-28	3.7e-27	1.3e-27	2.4e-27
5	Liver	mRNA stability	Apof	0.35	0.15	0.0e+00	0.29	0.29	0.3	0.29	1.5e-32	3.7e-32	5.1e-33	1.1e-32

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.2	0.3	0.9	-0.2	0.4	-0.3	1.0	-0.7
Area under the delay curve	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	0.1
BMI with tail	8.3	28.8	29.6	-5.4	5.4	-5.4	5.3	-5.2
BMI without tail	1.8	5.6	6.7	-2.3	2.3	-2.3	2.6	-2.3
Body weight	0.8	3.5	4.0	-1.9	1.8	-1.9	2.0	-1.7
Weight adjusted by age	0.0	0.1	0.1	0.2	-0.2	0.2	-0.4	0.3
Bone surface	0.1	0.2	0.7	0.2	-0.0	0.2	0.9	-0.6
Bone volume	0.2	0.4	1.4	-0.0	0.2	-0.1	1.2	-0.8
Breakpoint value in progressive ratio session	0.9	1.1	1.2	1.0	-1.0	1.0	-1.1	1.1
Number of licking bursts	1.8	2.9	3.4	-1.8	1.8	-1.8	1.6	-1.5
Context. condit. distance diff. score	0.3	0.3	0.4	-0.6	0.6	-0.6	0.6	-0.5
Locomotion velocity, session 1	0.1	0.1	0.3	-0.2	0.2	-0.2	0.5	-0.5
Locomotion distance, session 1	0.1	0.1	0.1	0.4	-0.3	0.4	0.1	0.0
Locomotion velocity, session 2	0.8	1.0	1.4	1.2	-1.1	1.2	-0.6	0.8
Locomotion distance, session 2	2.5	3.5	4.4	2.1	-2.0	2.1	-1.5	1.6
Locomotion velocity, session 3	4.6	5.3	6.2	2.2	-2.2	2.2	-2.5	2.3
Locomotion distance, session 3	0.2	0.2	0.3	0.4	-0.4	0.4	-0.4	0.5
Stereotopy head waving bouts, day 3	5.3	6.2	6.6	2.6	-2.5	2.5	-2.5	2.4
Stereotopy head waving duration, day 3	2.8	3.4	3.7	1.9	-1.8	1.8	-1.9	1.7
Locomotion velocity, session 7	0.0	0.0	0.0	0.1	-0.2	0.2	-0.0	0.0
Locomotion distance, session 7	0.1	0.1	0.2	-0.4	0.3	-0.4	0.1	-0.1
Stereotopy head waving bouts, day 7	0.5	0.6	0.7	0.8	-0.8	0.8	-0.7	0.7
Stereotopy head waving duration, day 7	0.5	0.6	0.9	0.9	-0.9	0.9	-0.6	0.5
Locomotion velocity, session 8	0.8	1.0	1.3	1.1	-1.0	1.1	-0.8	0.9
Locomotion distance, session 8	0.4	0.5	0.7	0.8	-0.8	0.8	-0.6	0.7
Degree of sensitization distance	0.9	1.0	1.1	-1.1	1.0	-1.0	0.9	-0.9
Degree of sensitization stereotypy	0.2	0.2	0.2	-0.4	0.5	-0.4	0.4	-0.4
Conditioned locomotion	0.5	0.6	0.8	-0.9	0.9	-0.9	0.4	-0.6
Cocaine response after cond. corrected	2.5	3.0	4.0	-1.9	1.9	-2.0	1.1	-1.4
Cocaine response after cond. not corrected	2.5	2.9	3.9	-1.9	1.9	-2.0	1.1	-1.4
Cocaine response before conditioning	0.6	0.7	0.9	0.9	-0.9	0.9	-0.7	0.8
Saline control response	0.1	0.2	0.2	-0.4	0.4	-0.4	0.5	-0.4
Bone: connectivity density	0.1	0.2	0.4	-0.3	0.4	-0.3	0.6	-0.5
Bone: cortical apparent density	1.5	2.0	2.2	-1.4	1.4	-1.4	1.5	-1.4
Bone: cortical area	1.2	1.8	3.0	-1.1	1.2	-1.2	1.7	-1.4
Bone: cortical porosity	0.0	0.0	0.2	-0.1	0.1	-0.1	0.4	-0.2
Bone: cortical porosity	0.3	0.3	0.7	-0.4	0.5	-0.4	0.9	-0.6
Bone: cortical thickness	1.8	3.0	4.5	-1.5	1.6	-1.5	2.1	-1.8
Bone: cortical thickness	0.5	0.5	0.6	-0.8	0.8	-0.8	0.8	-0.6
Bone: cortical tissue density	1.0	1.4	1.5	-1.2	1.2	-1.1	1.2	-1.2
Condit. Reinf. active minus inactive responses	1.3	1.5	1.9	1.1	-1.1	1.1	-1.4	1.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.0	0.1	-0.1	-0.6	0.5
Condit. Reinf. active responses	2.2	2.8	3.1	1.8	-1.7	1.8	-1.5	1.6
Condit. Reinf. inactive responses	1.9	2.3	3.2	1.7	-1.8	1.8	-1.0	1.0
Incentive salience index mean	0.8	1.0	1.1	1.0	-1.0	1.0	-0.9	1.0
Condit. Reinf. lever presses	0.2	0.2	0.4	0.6	-0.6	0.7	-0.2	0.1
Condit. Reinf. active minus inactive responses	2.5	3.3	4.0	1.7	-1.7	1.6	-2.0	2.0
Condit. Reinf. active-inactive response ratio	0.9	1.1	1.9	0.8	-0.8	0.7	-1.4	1.3
Condit. Reinf. active responses	1.7	2.3	2.6	1.5	-1.5	1.4	-1.6	1.6
Condit. Reinf. inactive responses	0.3	0.3	0.4	0.7	-0.6	0.7	-0.4	0.5
Condit. Reinf. lever presses	3.2	4.4	4.6	2.1	-2.1	2.1	-2.1	2.1
Condit. Reinf. lever reinforcers received	1.3	1.9	2.2	1.3	-1.3	1.3	-1.5	1.5
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.4	0.4	-0.4	0.3	-0.3
Conditioned reinforcement - inactives	0.4	0.6	0.7	-0.8	0.8	-0.9	0.7	-0.6
Conditioned locomotion	1.2	1.6	1.8	1.4	-1.3	1.4	-1.1	1.2
Patch foraging indifference point 0 sec	4.0	7.4	8.2	-2.6	2.7	-2.7	2.9	-2.8
Patch foraging indifference point AUC	0.5	0.8	1.3	0.7	-0.7	0.7	-1.2	1.0
Delay disc. indifference point, 0s delay	1.6	1.8	2.8	-1.1	1.2	-1.1	1.7	-1.5
Delay disc. indifference point, 16s delay	0.3	0.3	0.4	0.6	-0.6	0.6	-0.4	0.6
Delay disc. indifference point, 2s delay	0.2	0.3	0.5	-0.4	0.4	-0.4	0.7	-0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.3	0.3	-0.3	0.4	-0.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.6	-0.6	0.6	-0.2	0.3
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	0.1	-0.2	0.1	0.1
Indifference point function ln k	0.1	0.2	0.2	-0.4	0.4	-0.4	0.5	-0.4
Indifference point function log k	0.1	0.2	0.2	-0.4	0.4	-0.4	0.5	-0.4
Patch foraging total patch changes 0 sec	3.6	6.8	7.2	-2.5	2.6	-2.6	2.7	-2.6
Patch foraging total patch changes 12 sec	1.9	2.5	2.7	-1.7	1.6	-1.7	1.4	-1.4
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	-0.2	0.2	-0.2	0.2	-0.2
Patch foraging total patch changes 24 sec	0.4	0.7	0.9	-0.8	0.8	-0.8	0.9	-0.8
Patch foraging total patch changes 6 sec	2.3	3.5	3.7	-1.9	1.9	-1.9	1.9	-1.9
Patch foraging time to switch 0 sec	0.2	0.4	0.6	-0.4	0.4	-0.4	0.8	-0.8
Patch foraging water rate 0 sec	0.3	0.7	0.9	-0.9	0.9	-0.9	0.6	-0.5
Patch foraging water rate 12 sec	0.6	1.2	1.6	-1.3	1.2	-1.3	0.8	-0.8
Patch foraging water rate 18 sec	0.1	0.2	0.4	-0.1	-0.0	-0.1	-0.6	0.6
Patch foraging water rate 24 sec	0.8	1.1	1.7	-1.3	1.2	-1.3	0.6	-0.6
Patch foraging water rate 6 sec	0.4	0.5	1.0	0.4	-0.5	0.4	-1.0	1.0
Seeking ratio, delayed vs. immediate footshock	0.9	1.1	1.4	1.2	-1.2	1.2	-0.8	0.9
Distance traveled before self-admin	1.4	1.9	1.9	1.4	-1.4	1.4	-1.3	1.3
Distance traveled after self-admin	0.0	0.0	0.1	0.2	-0.2	0.2	-0.3	0.2
Extensor digitorum longus weight	4.9	19.1	20.6	-4.5	4.5	-4.5	4.2	-4.2
Bone: elastic displacement	0.0	0.0	0.0	0.1	-0.1	0.2	0.1	0.1
Bone: elastic work	0.7	0.9	1.7	-0.8	0.8	-0.8	1.3	-0.9
Bone: endosteal estimation	0.7	1.5	2.1	-1.1	1.0	-1.1	1.4	-1.4
Bone: endosteal perimeter	0.1	0.3	0.4	0.6	-0.6	0.6	-0.2	0.2
Epididymis fat weight	0.1	0.3	0.5	0.4	-0.4	0.3	-0.6	0.7
Delta time in closed arm before/after self-admin	1.1	1.0	1.5	-1.2	1.1	-1.2	0.7	-0.7
Delta time in open arm before/after self-admin	0.6	0.5	0.6	-0.7	0.7	-0.7	0.7	-0.7
Diff in mean of infusions in LGA sessions	2.0	2.5	2.6	1.6	-1.6	1.5	-1.6	1.6
Delay discount exponential model param	0.0	0.0	0.1	-0.2	0.2	-0.2	0.0	-0.2
Extinction: sum of active levers before priming	1.8	2.0	2.6	1.3	-1.3	1.3	-1.5	1.6
Active lever presses in extinction session 6	0.1	0.1	0.1	0.3	-0.3	0.3	-0.3	0.3
Bone: final force	3.2	5.2	7.0	-2.1	2.1	-2.1	2.6	-2.4
Bone: final moment	3.2	5.1	7.0	-2.1	2.1	-2.0	2.6	-2.4
Food consumed during 24 hour testing period	0.1	0.2	0.5	-0.3	0.2	-0.2	0.7	-0.5
Glucose	1.2	1.9	2.1	-1.4	1.5	-1.5	1.4	-1.2
Heart weight	0.3	0.4	0.7	0.5	-0.6	0.5	-0.8	0.7
Delay discount hyperbolic model param	0.0	0.0	0.1	0.1	-0.1	0.1	-0.4	0.2
Intermittent access intake day 1-15 change	0.3	0.6	0.9	0.7	-0.7	0.7	-1.0	0.8
Intermittent access intake escalation	0.3	0.6	0.9	0.6	-0.7	0.6	-0.9	0.8
Intermittent access intake escalation 2	0.7	0.8	1.5	0.8	-0.8	0.8	-1.2	0.9
Intermitt. access day 1 inactive lever presses	0.2	0.9	1.5	0.7	-0.8	0.7	-1.1	1.2
Intermitt. access day 15 inactive lever presses	0.7	1.4	1.6	1.2	-1.2	1.2	-1.1	1.2
Intermitt. access escalation Index	0.1	0.1	0.3	-0.2	0.2	-0.1	0.4	-0.5
Intermittent access day 1 total infusions	0.2	0.3	0.4	-0.6	0.6	-0.6	0.4	-0.5
Intermittent access day 15 total infusions	0.0	0.0	0.1	-0.2	0.2	-0.2	0.2	-0.3
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	-0.0	0.1	-0.0	0.2	-0.2
Intermittent access total infusions	0.3	0.3	0.4	-0.5	0.6	-0.5	0.6	-0.6
Intermittent access day 1 locomotion	0.0	0.1	0.1	-0.3	0.3	-0.3	-0.1	0.0
Intermittent access day 15 total locomotion	0.1	0.1	0.3	0.2	-0.2	0.2	-0.5	0.4
Intermittent access total locomotion	0.1	0.1	0.1	0.2	-0.2	0.2	-0.3	0.3
Intermittent access standard deviation	0.3	0.5	0.6	0.8	-0.8	0.8	-0.8	0.6
Left kidney weight	0.0	0.1	0.1	0.3	-0.4	0.3	-0.3	0.3
Right kidney weight	0.3	1.3	1.4	1.1	-1.2	1.1	-1.1	1.2
Cocaine induced anxiety	1.0	1.4	1.8	1.3	-1.3	1.3	-0.9	1.0
Post-drug Anxiety	0.3	0.3	0.6	0.8	-0.6	0.8	-0.2	0.2
Baseline Anxiety	0.0	0.0	0.0	-0.2	0.2	-0.2	0.2	-0.2
Tail length	4.5	17.6	18.5	4.2	-4.3	4.3	-3.9	4.3
Length with tail	2.1	9.0	9.9	3.0	-3.1	3.0	-2.8	3.1
Length without tail	0.2	0.6	0.7	-0.8	0.8	-0.9	0.6	-0.6
Times rat made contact with spout	0.8	0.9	1.1	-1.0	1.0	-1.0	0.9	-0.8
Lifetime Intake	1.2	1.5	1.7	-1.1	1.2	-1.1	1.3	-1.3
Liver weight, left	0.2	0.3	0.6	-0.5	0.5	-0.5	0.8	-0.6
Liver weight, right	0.3	0.4	0.8	0.6	-0.6	0.5	-0.7	0.9
Locomotor activity	3.8	5.9	7.0	2.6	-2.6	2.7	-2.0	2.1
Locomotor testing distance	1.4	2.5	3.0	1.7	-1.7	1.7	-1.3	1.3
Locomotor testing rearing	0.1	0.2	0.2	0.4	-0.4	0.4	-0.3	0.4
Locomotion in novel chamber	0.1	0.1	0.2	-0.3	0.3	-0.3	0.2	-0.4
Locomotion in novel chamber post-restriction	4.0	6.6	6.8	2.6	-2.5	2.5	-2.6	2.6
Fecal boli incidents, locomotor time 1	0.3	0.5	0.7	-0.8	0.8	-0.8	0.5	-0.5
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	0.7	-0.7	0.7	-0.3	0.2
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.0	-0.6	0.7	-0.6	1.0	-0.9
Bouts of movement, locomotor time 1	0.9	1.0	1.2	1.0	-1.0	1.0	-0.9	1.1
Total resting periods, locomotor time 1	1.8	2.0	2.2	1.4	-1.4	1.4	-1.3	1.5
Rest time, locomotor task time 1	0.6	0.7	0.9	0.9	-0.9	0.9	-0.7	0.8
Distance moved, locomotor task time 1	1.0	1.4	2.0	-1.1	1.1	-1.0	1.3	-1.4
Vertical activity count, locomotor time 1	0.8	2.0	2.1	-1.5	1.4	-1.4	1.3	-1.4
Time >=10cm from walls, locomotor time 2	0.8	1.1	1.3	-1.1	1.1	-1.1	1.0	-0.9
Bouts of movement, locomotor time 2	0.2	0.3	0.4	0.7	-0.6	0.6	-0.1	0.3
Total resting periods, locomotor time 2	0.1	0.2	0.4	0.6	-0.6	0.6	0.0	0.3
Rest time, locomotor task time 2	0.0	0.1	0.1	0.3	-0.3	0.3	-0.0	0.1
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.1	-0.0
Vertical activity count, locomotor time 2	0.8	1.1	1.4	-1.2	1.1	-1.2	0.8	-0.9
Light reinforcement 1	2.8	6.9	7.8	2.8	-2.7	2.8	-2.2	2.5
Light reinforcement 2	1.4	2.1	2.5	1.6	-1.5	1.6	-1.0	1.4
Bone: marrow area	0.6	1.3	1.8	-1.0	1.0	-1.0	1.3	-1.4
Bone: maximum diameter	0.1	0.2	0.4	0.6	-0.6	0.6	-0.1	0.4
Bone: maximum force	3.1	5.5	7.1	-2.2	2.2	-2.2	2.7	-2.4
Bone: maximum moment	3.1	5.5	7.1	-2.2	2.2	-2.2	2.7	-2.5
Mean time between licks in bursts	0.4	0.9	1.0	0.9	-1.0	1.0	-1.0	0.9
Mean num. licks in bursts	0.5	0.8	1.0	1.0	-1.0	1.0	-0.8	0.8
Cd content in liver	0.1	0.1	0.2	0.4	-0.4	0.4	-0.3	0.1
Co content in liver	3.5	4.0	4.4	2.0	-2.1	2.1	-2.0	1.8
Cu content in liver	0.6	0.7	1.1	-0.7	0.7	-0.7	1.1	-1.0
Fe content in liver	0.3	0.3	0.4	-0.6	0.6	-0.6	0.4	-0.5
K content in liver	0.7	0.7	1.0	1.0	-0.9	1.0	-0.6	0.6
Mg content in liver	1.3	1.3	1.5	1.2	-1.2	1.2	-1.0	1.1
Mn content in liver	0.9	1.0	1.5	1.2	-1.1	1.2	-0.6	0.5
Na content in liver	0.2	0.2	0.3	-0.5	0.6	-0.5	0.4	-0.4
Rb content in liver	0.3	0.4	0.8	-0.4	0.5	-0.4	0.9	-0.6
Se content in liver	0.0	0.0	0.0	-0.1	0.1	-0.2	-0.1	-0.1
Sr content in liver	0.2	0.2	0.2	0.4	-0.5	0.4	-0.4	0.3
Zn content in liver	4.0	4.4	5.7	1.9	-2.0	1.9	-2.2	2.4
Bone: minimum diameter	0.3	0.6	1.2	-0.6	0.6	-0.6	1.1	-0.9
Time in familiar zone, hab. session 1	5.8	5.6	6.1	2.3	-2.3	2.2	-2.5	2.5
Time in novel zone, hab. session 1	4.1	4.1	5.3	-1.8	1.9	-1.8	2.3	-2.2
Total zone transitions, hab. session 1	0.3	0.4	0.5	0.7	-0.6	0.7	-0.3	0.5
Total locomotion distance, hab. session 1	1.2	1.7	2.4	1.5	-1.5	1.5	-0.9	1.0
Locomotion velocity, hab. session 1	1.4	2.0	2.5	1.6	-1.5	1.6	-1.1	1.1
Time in familiar zone, hab. session 2	6.3	6.6	6.8	2.5	-2.6	2.5	-2.6	2.6
Time in novel zone, hab. session 2	7.3	7.4	7.7	-2.6	2.7	-2.7	2.8	-2.8
Total zone transitions, hab. session 2	0.7	0.9	1.6	-0.7	0.8	-0.7	1.3	-1.2
Total locomotion distance, hab. session 2	0.4	0.5	0.7	0.8	-0.8	0.9	-0.3	0.3
Locomotion velocity, hab. session 2	0.4	0.5	0.9	0.9	-0.9	0.9	-0.3	0.3
Novel to familiar place preference ratio	3.6	3.9	4.4	-1.9	2.0	-1.9	2.1	-2.1
Novelty place preference	2.4	2.6	3.1	-1.5	1.6	-1.5	1.8	-1.7
Time in novel zone, NPP test	3.2	3.5	4.0	-1.8	1.8	-1.8	2.0	-1.9
Total zone transitions, NPP test	0.3	0.5	0.7	-0.5	0.6	-0.5	0.9	-0.8
Total locomotion distance, NPP test	0.1	0.1	0.2	0.0	-0.0	0.1	0.5	-0.4
Locomotion velocity, NPP test	0.1	0.1	0.2	0.4	-0.3	0.4	0.1	-0.1
Intraocular pressure	0.5	0.8	1.2	0.7	-0.8	0.8	-1.1	0.9
Delta distance traveled before/after self-admin	0.5	0.6	0.6	-0.8	0.8	-0.8	0.6	-0.7
Delta ambulatory time before/after self-admin	0.6	0.7	0.8	-0.8	0.8	-0.8	0.8	-0.9
Parametrial fat weight	0.5	1.2	1.3	-1.1	1.1	-1.1	1.1	-1.1
Pavlov. Cond. lever latency	0.0	0.0	0.1	-0.2	0.1	-0.2	-0.2	0.3
Pavlov. Cond. magazine entry latency	1.6	2.0	2.2	1.5	-1.5	1.5	-1.3	1.3
Pavlov. Cond. change in total contacts	0.3	0.3	0.4	-0.5	0.5	-0.5	0.6	-0.5
Pavlov. Cond. index score	0.4	0.5	0.7	0.8	-0.8	0.8	-0.5	0.5
Pavlov. Cond. latency score	0.3	0.4	0.6	0.8	-0.8	0.8	-0.4	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.0	0.1	-0.0	0.4	-0.4
Pavlov. Cond. magazine entry number	0.7	0.9	1.0	-1.0	1.0	-1.0	0.9	-0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.2	-0.3	0.2	-0.4	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	0.8	-0.8	0.8	-0.6	0.6
Pavlov. Cond. response bias	0.5	0.7	0.7	0.9	-0.9	0.8	-0.8	0.8
Pavlov. Cond. lever latency	2.3	3.1	3.6	-1.8	1.9	-1.9	1.5	-1.7
Pavlov. Cond. magazine entry latency	3.0	3.6	4.1	2.0	-2.0	2.0	-1.6	1.8
Pavlov. Cond. change in total contacts	0.8	1.3	1.5	1.2	-1.2	1.2	-1.1	1.1
Pavlov. Cond. index score	2.6	3.4	3.9	1.9	-2.0	2.0	-1.6	1.8
Pavlov. Cond. latency score	2.8	3.7	4.2	2.0	-2.1	2.0	-1.7	1.8
Pavlov. Cond. lever contacts	2.2	3.0	3.4	1.8	-1.8	1.8	-1.5	1.7
Pavlov. Cond. magazine entry number	2.9	3.6	4.1	-2.0	2.0	-2.0	1.6	-1.8
Pavlov. Cond. intertrial magazine entries	0.9	1.4	1.7	-1.3	1.3	-1.3	1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	2.7	3.6	4.1	2.0	-2.0	2.0	-1.6	1.8
Pavlov. Cond. response bias	3.2	4.4	4.9	2.1	-2.2	2.2	-1.9	2.0
Time in closed arm before self-admin	0.1	0.1	0.3	-0.2	0.2	-0.2	0.5	-0.6
Time in closed arm after self-admin	0.7	0.7	0.8	-0.9	0.8	-0.9	0.8	-0.9
Time in open arm before self-admin	0.0	0.0	0.0	-0.1	0.2	-0.2	0.0	-0.1
Time in open arm after self-admin	1.3	1.4	1.7	-1.3	1.3	-1.3	1.0	-1.1
Bone: periosteal estimation	1.2	2.5	4.0	-1.3	1.3	-1.3	2.0	-1.8
Bone: periosteal perimeter	0.1	0.1	0.4	-0.1	0.1	-0.1	0.7	-0.5
Bone: post-yield work	0.5	0.8	0.9	-0.9	0.8	-0.9	0.9	-0.9
Progressive ratio test 1 active lever presses	0.5	0.7	0.7	-0.8	0.8	-0.8	0.8	-0.8
Progressive ratio test 1 breakpoint	0.6	0.7	0.7	-0.9	0.8	-0.9	0.8	-0.8
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.1	0.3	-0.3	0.3	-0.2	0.3
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.1	-0.1	0.1	-0.0	0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.2	-0.2	0.2	-0.2	0.2
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.5	-0.4	0.5	-0.4	0.7	-0.6
Incentive Sensitization - Responses	0.4	0.5	0.6	0.7	-0.7	0.7	-0.7	0.8
Incentive Sensitization - Breakpoint	0.5	0.7	0.7	0.8	-0.8	0.8	-0.8	0.8
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.2	0.4	-0.4	0.4	-0.4	0.4
Progressive ratio	1.0	1.6	1.9	-1.4	1.4	-1.4	1.0	-1.2
Food seeking constrained by brief footshock	2.5	3.1	3.3	1.7	-1.7	1.7	-1.8	1.8
Seeking ratio, punishment vs. effort	3.0	4.3	4.5	2.1	-2.1	2.1	-2.0	2.1
Retroperitoneal fat weight	2.0	8.7	10.2	-3.2	3.1	-3.2	2.5	-2.7
Reaction time number correct	0.5	0.9	1.2	-1.1	1.0	-1.1	0.6	-0.8
Reaction time mean minus median	0.7	1.8	2.0	1.3	-1.3	1.3	-1.4	1.3
Reaction time mean minus median AUC	0.6	1.5	1.9	1.3	-1.3	1.4	-1.1	0.9
Reaction time num false alarms	0.4	0.5	0.7	-0.7	0.7	-0.7	0.9	-0.8
Reaction time num false alarms AUC	0.3	0.4	0.6	-0.6	0.6	-0.6	0.8	-0.7
Reaction time trials correct on left	0.5	0.9	1.2	-1.1	1.0	-1.1	0.6	-0.8
Reaction time trials on left	0.5	0.9	1.2	-1.1	1.0	-1.1	0.6	-0.8
Reaction time mean	0.7	1.1	1.3	1.1	-1.1	1.1	-1.0	0.7
Reaction time mean AUC	0.2	0.3	0.3	0.6	-0.5	0.6	-0.6	0.2
Median of all reaction times	0.3	0.5	0.6	0.8	-0.8	0.8	-0.7	0.4
Reaction time omissions	0.0	0.1	0.2	-0.1	0.2	-0.1	0.2	-0.4
Reaction time false alarm rate	0.1	0.1	0.3	-0.1	0.1	-0.1	0.6	-0.3
Reaction time premature initiation rate	1.7	2.4	3.4	1.4	-1.5	1.4	-1.8	1.5
Reaction time premature initiations	0.6	1.1	2.2	0.8	-0.8	0.8	-1.5	1.1
Std. dev. reaction times	0.4	0.7	0.9	0.9	-0.8	0.9	-0.9	0.6
Reaction time trials completed	0.5	0.9	1.2	-1.1	1.0	-1.1	0.6	-0.8
Reaction time trials AUC	0.5	1.0	1.3	-1.1	1.1	-1.1	0.6	-0.8
Run reversals in cocaine runway, females	2.4	2.4	2.6	1.6	-1.6	1.6	-1.6	1.5
Run reversals in cocaine runway, males	1.7	1.7	1.9	1.4	-1.3	1.4	-1.2	1.2
Latency to leave start box in cocaine runway	0.1	0.2	0.4	-0.0	0.1	-0.0	0.6	-0.6
Latency to leave start box in cocaine runway, F	0.3	0.3	0.8	-0.3	0.4	-0.3	0.8	-0.9
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.2	-0.3	0.2	-0.1	0.2
Std. dev. time between licks in bursts	0.4	0.6	0.8	0.9	-0.9	0.9	-0.5	0.5
Total sessions with >9 infusions	1.1	1.4	2.0	-1.0	1.1	-1.0	1.4	-1.2
Short access day 1 total inactive lever presses	0.3	0.4	0.7	0.6	-0.6	0.6	-0.6	0.8
Short access day 10 total inactive lever presses	0.1	0.2	0.6	0.3	-0.3	0.2	-0.6	0.8
Short access day 1 total infusions	1.0	1.3	1.9	-1.0	1.0	-1.0	1.4	-1.2
Short access day 10 total infusions	0.4	0.5	0.6	-0.7	0.8	-0.7	0.6	-0.6
Short access total infusions	1.5	2.0	2.5	-1.3	1.3	-1.3	1.6	-1.5
Short access day 1 locomotion	0.2	0.2	0.3	0.5	-0.5	0.5	-0.3	0.6
Short access day 10 total locomotion	1.2	2.2	4.0	1.1	-1.1	1.1	-2.0	1.7
Short access total locomotion	0.1	0.2	0.3	0.3	-0.3	0.3	-0.5	0.5
One hour access (0.3 mA shock)	0.2	0.3	0.4	-0.6	0.6	-0.6	0.3	-0.4
Compulsive drug intake	0.0	0.0	0.1	0.2	-0.2	0.2	-0.0	0.1
One hour access (shock baseline)	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.2	0.1
Social response proportion	1.2	1.3	1.4	1.2	-1.1	1.2	-1.2	1.1
Social responses	10.2	13.1	13.9	3.7	-3.7	3.7	-3.5	3.5
Social time	1.0	1.3	1.5	-1.2	1.2	-1.2	0.9	-1.1
Soleus weight	6.1	18.1	18.5	-4.2	4.2	-4.2	4.3	-4.3
Bone: stiffness	4.8	7.8	8.4	-2.7	2.7	-2.7	2.9	-2.8
Tibialis anterior weight	1.5	4.9	5.1	-2.3	2.3	-2.2	2.1	-2.2
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.0	1.0	-0.9	1.0	-0.8	0.7
Time to tail flick, vehicle, after self-admin	0.6	0.8	1.8	0.6	-0.6	0.6	-1.3	1.0
Time to tail flick, test, before self-admin	0.4	0.4	0.6	0.8	-0.7	0.8	-0.3	0.4
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.0	0.1	-0.0	0.2	-0.3
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	0.9	-0.9	0.9	-1.0	0.2	-0.5
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.4	0.3
Tibia length	1.5	4.1	4.6	2.1	-2.1	2.1	-1.8	2.1
Ambulatory time before self-admin	0.4	0.5	0.6	0.7	-0.7	0.7	-0.7	0.7
Ambulatory time after self-admin	0.0	0.0	0.0	0.0	-0.0	0.0	-0.1	0.0
Bone: tissue strength	6.6	6.6	7.1	-2.5	2.6	-2.5	2.7	-2.6
Total heroin consumption	2.2	2.6	2.7	1.7	-1.6	1.6	-1.6	1.6
Bone: trabecular number	0.2	0.4	0.6	0.8	-0.6	0.7	-0.3	0.5
Bone: trabecular spacing	0.1	0.1	0.2	-0.4	0.3	-0.4	-0.3	-0.0
Bone: trabecular thickness	0.4	0.5	1.7	-0.2	0.3	-0.2	1.3	-0.9
Bone: trabecular tissue density	5.2	7.7	8.4	-2.9	2.8	-2.9	2.5	-2.8
Water consumed over 24 hours	0.5	0.7	1.4	-0.6	0.6	-0.6	1.2	-1.0
Number of responses in last shaping day	1.9	2.1	2.4	1.4	-1.4	1.4	-1.5	1.5