Hub : Genes

Apoe

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Apoe	0.07	0.05	6.3e-06	0.05	0.04	0.04	0.05	1.1e-05	7.9e-05	2.6e-04	3.4e-05
2	NAcc	gene expression	Apoe	0.03	0.02	1.7e-04	0.02	0.02	0.02	0.02	1.6e-04	2.0e-04	2.5e-04	7.5e-04
3	Adipose	intron excision ratio	chr1_88483851_88484627	0.03	0.03	6.7e-03	0.02	0.01	0.01	0.02	1.5e-03	3.0e-02	1.4e-02	4.8e-03
4	Eye	intron excision ratio	chr1_88483851_88484627	0.58	0.17	3.7e-07	0.32	0.31	0.27	0.32	6.2e-06	9.2e-06	4.3e-05	8.3e-06
5	Eye	isoform ratio	NM_138828.3	0.8	0.1	5.5e-09	0.25	0.26	0.24	0.3	1.1e-04	7.2e-05	1.2e-04	1.3e-05
6	PL	gene expression	Apoe	0.07	0.04	4.5e-09	0.07	0.08	0.07	0.07	2.2e-08	4.2e-09	4.5e-08	2.1e-08
7	Liver	gene expression	Apoe	0.05	0.05	4.9e-05	0.05	0.04	0.04	0.04	3.1e-06	6.2e-05	5.4e-05	8.7e-06
8	Liver	mRNA stability	Apoe	0.07	0.04	1.8e-08	0.05	0.06	0.05	0.05	1.9e-06	7.0e-07	3.4e-06	1.2e-06
9	Adipose	intron excision ratio	chr1_88483851_88484587	0.03	0.02	1.2e-03	0.02	0.02	0.02	0.02	1.8e-03	1.0e-03	5.1e-03	1.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.0	0.0	0.1	0.0	-0.2	-0.1	0.2	0.3	-0.2	0.3	-0.2	-0.1
Area under the delay curve	2.0	2.3	3.2	1.3	1.5	-1.4	-1.5	-1.5	1.4	-1.8	1.6	1.7
BMI with tail	0.7	2.3	3.4	-1.4	-1.8	1.3	1.3	1.3	-1.6	1.8	-1.5	-1.4
BMI without tail	0.6	1.8	2.3	-1.3	-1.5	1.3	1.3	1.3	-1.4	1.3	-1.3	-1.2
Body weight	1.1	4.9	5.8	-2.2	-2.4	2.2	2.2	2.2	-2.3	2.4	-2.1	-2.0
Weight adjusted by age	0.0	0.0	0.1	0.0	0.0	0.1	-0.1	-0.1	-0.0	0.3	-0.0	-0.1
Bone surface	0.3	0.6	0.9	-0.6	-0.9	0.6	0.9	0.8	-0.9	1.0	-0.8	-0.7
Bone volume	0.2	0.4	0.7	-0.5	-0.6	0.5	0.8	0.8	-0.7	0.8	-0.6	-0.5
Breakpoint value in progressive ratio session	2.3	2.7	3.0	1.7	1.6	-1.6	-1.7	-1.7	1.6	-1.5	1.7	1.7
Number of licking bursts	1.5	2.5	4.4	-2.0	-1.3	2.1	1.4	1.4	-1.5	1.5	-1.4	-1.4
Context. condit. distance diff. score	0.1	0.2	0.3	-0.5	-0.5	0.3	0.4	0.3	-0.4	0.4	-0.3	-0.3
Locomotion velocity, session 1	0.1	0.1	0.2	0.1	0.3	-0.3	-0.3	-0.4	0.3	-0.1	0.4	0.4
Locomotion distance, session 1	0.1	0.1	0.2	-0.4	-0.3	0.1	0.4	0.4	-0.3	0.3	-0.2	-0.2
Locomotion velocity, session 2	0.9	1.0	1.6	-1.2	-0.7	1.3	1.0	1.0	-1.0	0.8	-1.0	-1.1
Locomotion distance, session 2	0.4	0.5	0.7	-0.7	-0.6	0.5	0.8	0.8	-0.7	0.7	-0.8	-0.8
Locomotion velocity, session 3	0.2	0.2	0.3	-0.3	-0.4	0.5	0.5	0.5	-0.4	0.3	-0.5	-0.6
Locomotion distance, session 3	0.6	0.7	1.1	1.1	0.9	-0.9	-0.8	-0.8	0.9	-1.0	0.6	0.5
Stereotopy head waving bouts, day 3	0.7	0.8	1.3	-0.9	-0.8	1.1	0.7	0.8	-0.9	0.6	-1.0	-1.1
Stereotopy head waving duration, day 3	1.0	1.2	1.4	-1.1	-1.1	1.2	1.0	1.0	-1.1	0.9	-1.1	-1.1
Locomotion velocity, session 7	0.1	0.1	0.4	0.6	0.0	-0.4	-0.1	-0.1	0.2	0.0	0.2	0.2
Locomotion distance, session 7	0.1	0.1	0.3	-0.1	-0.6	0.2	0.3	0.2	-0.3	0.4	-0.3	-0.2
Stereotopy head waving bouts, day 7	0.9	1.0	1.2	-0.9	-1.0	1.0	1.0	1.0	-1.0	1.1	-1.1	-1.1
Stereotopy head waving duration, day 7	0.7	0.8	0.9	-0.8	-0.9	1.0	0.9	0.9	-0.9	1.0	-0.9	-0.9
Locomotion velocity, session 8	0.0	0.0	0.1	-0.0	0.3	-0.0	-0.1	-0.2	0.2	-0.4	0.1	-0.0
Locomotion distance, session 8	0.0	0.1	0.1	-0.3	-0.2	-0.0	0.4	0.4	-0.2	0.3	-0.2	-0.2
Degree of sensitization distance	0.6	0.6	1.1	-0.9	-1.1	0.8	0.7	0.7	-0.9	0.8	-0.6	-0.4
Degree of sensitization stereotypy	1.0	1.1	1.2	-1.0	-1.0	1.0	1.0	1.0	-1.0	1.1	-1.1	-1.1
Conditioned locomotion	0.1	0.1	0.2	0.2	0.3	-0.2	-0.2	-0.2	0.2	-0.4	-0.1	-0.3
Cocaine response after cond. corrected	0.7	0.9	1.2	-0.9	-1.0	0.8	0.8	0.8	-0.9	0.9	-1.1	-1.1
Cocaine response after cond. not corrected	1.8	2.2	3.1	-1.3	-1.6	1.3	1.3	1.3	-1.5	1.5	-1.7	-1.7
Cocaine response before conditioning	1.6	1.9	2.6	-1.2	-1.3	1.3	1.3	1.4	-1.4	1.4	-1.5	-1.6
Saline control response	1.9	2.5	3.0	-1.7	-1.5	1.7	1.7	1.7	-1.6	1.5	-1.5	-1.4
Bone: connectivity density	0.0	0.0	0.1	0.1	-0.1	-0.3	0.0	0.1	-0.0	-0.0	0.0	0.1
Bone: cortical apparent density	0.1	0.1	0.2	0.4	0.4	-0.4	-0.1	-0.1	0.3	-0.5	0.4	0.4
Bone: cortical area	1.4	2.2	2.6	-1.5	-1.4	1.6	1.6	1.6	-1.5	1.5	-1.4	-1.3
Bone: cortical porosity	0.3	0.4	0.8	0.6	0.9	-0.3	-0.7	-0.6	0.7	-0.8	0.3	0.0
Bone: cortical porosity	0.1	0.1	0.2	0.2	0.4	0.0	-0.3	-0.2	0.3	-0.5	-0.1	-0.3
Bone: cortical thickness	0.5	0.9	1.1	-1.0	-0.9	1.0	1.0	1.0	-0.9	0.8	-0.9	-0.9
Bone: cortical thickness	1.5	1.8	1.9	-1.4	-1.3	1.3	1.4	1.4	-1.3	1.3	-1.3	-1.4
Bone: cortical tissue density	0.1	0.2	0.3	0.6	0.4	-0.5	-0.2	-0.2	0.4	-0.6	0.5	0.5
Condit. Reinf. active minus inactive responses	0.4	0.5	0.7	-0.2	-0.7	0.5	0.7	0.7	-0.8	0.8	-0.8	-0.7
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.9	-0.2	-0.8	0.3	0.7	0.7	-0.8	1.0	-0.8	-0.7
Condit. Reinf. active responses	0.3	0.4	0.5	-0.1	-0.6	0.4	0.6	0.6	-0.7	0.7	-0.7	-0.7
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.2	0.0	-0.3	0.1	0.1	0.0	-0.1	0.0	0.0
Incentive salience index mean	0.2	0.3	0.4	-0.1	-0.4	0.4	0.5	0.6	-0.5	0.6	-0.6	-0.7
Condit. Reinf. lever presses	0.0	0.0	0.1	0.3	0.0	0.0	0.1	0.2	-0.0	0.2	-0.1	-0.2
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	-0.3	-0.5	0.3	0.3	0.3	-0.4	0.6	-0.5	-0.5
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.4	-0.7	-1.0	0.6	0.8	0.8	-0.9	1.0	-1.1	-1.2
Condit. Reinf. active responses	0.1	0.1	0.2	0.3	0.3	-0.3	-0.4	-0.4	0.3	-0.2	0.2	0.2
Condit. Reinf. inactive responses	0.9	1.1	1.4	1.0	1.1	-1.0	-1.1	-1.1	1.0	-1.2	1.1	1.1
Condit. Reinf. lever presses	0.2	0.3	0.5	-0.5	-0.7	0.4	0.3	0.3	-0.6	0.7	-0.4	-0.3
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	0.3	0.3	-0.3	-0.5	-0.4	0.3	-0.3	0.2	0.2
Conditioned reinforcement - actives	1.5	2.5	3.2	-1.5	-1.7	1.4	1.5	1.5	-1.6	1.8	-1.6	-1.6
Conditioned reinforcement - inactives	0.4	0.7	1.1	-0.7	-0.9	0.8	0.7	0.7	-0.8	1.1	-0.8	-0.8
Conditioned locomotion	2.7	3.5	4.9	-1.8	-1.9	1.7	1.7	1.8	-1.8	2.2	-1.9	-1.9
Patch foraging indifference point 0 sec	0.3	0.6	1.0	-1.0	-0.7	0.9	0.8	0.8	-0.8	0.4	-0.8	-0.9
Patch foraging indifference point AUC	2.5	3.7	4.8	-2.2	-1.7	2.2	1.9	1.9	-1.9	1.6	-1.9	-1.9
Delay disc. indifference point, 0s delay	1.5	1.6	2.2	1.2	1.2	-1.2	-1.3	-1.3	1.3	-1.5	1.2	1.2
Delay disc. indifference point, 16s delay	1.6	1.7	3.1	1.1	1.5	-1.1	-1.1	-1.2	1.1	-1.8	1.4	1.5
Delay disc. indifference point, 2s delay	4.3	4.8	6.2	1.9	2.0	-1.9	-2.3	-2.3	2.1	-2.1	2.4	2.5
Delay disc. indifference point, 24s delay	0.2	0.2	0.7	-0.3	-0.6	0.2	0.4	0.4	-0.6	0.9	-0.3	-0.2
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.0	-0.2	0.0	-0.2	-0.2	0.0	-0.3	0.0	0.0
Delay disc. indifference point, 8s delay	2.0	2.3	3.1	1.4	1.5	-1.4	-1.5	-1.5	1.4	-1.8	1.6	1.7
Indifference point function ln k	0.6	1.1	1.6	1.1	1.0	-1.2	-0.9	-0.9	1.0	-0.9	1.1	1.1
Indifference point function log k	0.6	1.1	1.6	1.1	1.0	-1.2	-0.9	-0.9	1.0	-0.9	1.1	1.1
Patch foraging total patch changes 0 sec	0.6	1.1	1.8	-1.3	-0.9	1.1	1.1	1.1	-1.1	0.7	-1.0	-1.0
Patch foraging total patch changes 12 sec	1.1	1.5	1.9	-1.3	-1.2	1.4	1.0	1.1	-1.2	0.9	-1.3	-1.4
Patch foraging total patch changes 18 sec	1.9	2.9	3.9	-2.0	-1.7	1.7	1.7	1.7	-1.8	1.3	-1.7	-1.6
Patch foraging total patch changes 24 sec	0.3	0.6	0.7	-0.9	-0.8	0.7	0.7	0.7	-0.8	0.4	-0.8	-0.8
Patch foraging total patch changes 6 sec	2.3	3.5	4.7	-2.2	-1.7	1.9	1.9	1.9	-1.8	1.3	-1.9	-2.0
Patch foraging time to switch 0 sec	2.8	5.8	6.2	2.5	2.4	-2.3	-2.4	-2.5	2.5	-2.2	2.5	2.4
Patch foraging water rate 0 sec	3.1	6.4	7.1	-2.7	-2.6	2.4	2.6	2.6	-2.6	2.1	-2.6	-2.6
Patch foraging water rate 12 sec	0.2	0.4	0.6	-0.6	-0.7	0.4	0.7	0.7	-0.7	0.6	-0.6	-0.6
Patch foraging water rate 18 sec	0.2	0.3	0.5	-0.7	-0.6	0.4	0.6	0.6	-0.6	0.1	-0.4	-0.3
Patch foraging water rate 24 sec	0.6	0.9	1.2	-1.1	-1.0	0.9	1.0	0.9	-1.0	0.7	-0.9	-0.9
Patch foraging water rate 6 sec	0.8	1.2	1.5	-1.1	-1.2	0.9	1.2	1.2	-1.2	1.2	-0.9	-0.8
Seeking ratio, delayed vs. immediate footshock	1.8	2.1	2.8	1.6	1.4	-1.6	-1.4	-1.3	1.5	-1.7	1.4	1.3
Distance traveled before self-admin	0.1	0.1	0.1	-0.4	-0.3	0.3	0.3	0.3	-0.3	0.3	-0.3	-0.3
Distance traveled after self-admin	0.2	0.2	0.5	0.4	0.5	-0.4	-0.4	-0.4	0.5	-0.7	0.4	0.3
Extensor digitorum longus weight	1.7	6.5	8.0	-2.7	-2.5	2.7	2.8	2.8	-2.6	2.4	-2.3	-2.1
Bone: elastic displacement	1.0	1.2	1.4	1.2	1.1	-1.2	-1.1	-1.0	1.1	-1.0	1.0	0.9
Bone: elastic work	0.0	0.0	0.2	-0.1	-0.2	0.1	0.2	0.2	-0.1	0.1	-0.3	-0.4
Bone: endosteal estimation	0.0	0.0	0.1	0.4	-0.0	-0.3	-0.1	-0.1	0.1	0.1	0.1	0.1
Bone: endosteal perimeter	0.0	0.0	0.0	0.2	0.0	-0.1	-0.1	-0.1	0.0	0.1	0.1	0.2
Epididymis fat weight	0.3	1.0	1.3	0.8	1.1	-0.9	-1.0	-1.0	1.1	-1.0	1.1	1.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.2	0.2	-0.4	-0.2	-0.2	0.2	-0.4	0.3	0.4
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.2	0.2	-0.0	0.1	0.1
Diff in mean of infusions in LGA sessions	1.4	1.7	1.9	1.3	1.2	-1.3	-1.3	-1.3	1.3	-1.1	1.4	1.4
Delay discount exponential model param	1.5	1.6	2.2	-1.1	-1.2	1.1	1.3	1.3	-1.2	1.5	-1.4	-1.4
Extinction: sum of active levers before priming	0.1	0.1	0.1	0.3	0.3	-0.2	-0.3	-0.3	0.3	-0.3	0.2	0.1
Active lever presses in extinction session 6	0.1	0.1	0.5	-0.2	-0.2	0.2	0.2	0.2	-0.3	0.7	-0.2	-0.1
Bone: final force	0.4	0.6	0.8	-0.8	-0.9	0.8	0.8	0.8	-0.8	0.7	-0.8	-0.8
Bone: final moment	0.6	0.9	1.1	-0.9	-1.0	1.0	0.9	0.9	-1.0	0.8	-1.0	-1.0
Food consumed during 24 hour testing period	4.3	5.9	7.6	2.6	2.3	-2.8	-2.5	-2.5	2.4	-2.3	2.3	2.3
Glucose	0.2	0.4	0.8	0.6	0.2	-0.6	-0.9	-0.9	0.5	-0.6	0.5	0.5
Heart weight	2.1	3.2	3.6	-1.7	-1.8	1.9	1.8	1.8	-1.8	1.7	-1.8	-1.8
Delay discount hyperbolic model param	1.4	1.6	2.1	-1.1	-1.2	1.0	1.3	1.3	-1.1	1.4	-1.3	-1.4
Intermittent access intake day 1-15 change	0.1	0.2	0.4	-0.4	-0.5	0.4	0.4	0.4	-0.4	0.6	-0.3	-0.2
Intermittent access intake escalation	0.1	0.3	0.6	-0.5	-0.7	0.5	0.5	0.5	-0.6	0.8	-0.4	-0.3
Intermittent access intake escalation 2	0.0	0.0	0.1	-0.1	-0.3	0.1	0.1	0.1	-0.1	0.3	-0.2	-0.2
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	-0.0	-0.2	0.1	0.0	0.0	-0.1	0.1	-0.0	-0.0
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	-0.0	0.1	0.0	0.0	-0.0	-0.1	-0.0	0.2	0.3
Intermitt. access escalation Index	0.3	0.4	0.6	0.6	0.8	-0.6	-0.5	-0.5	0.6	-0.7	0.7	0.7
Intermittent access day 1 total infusions	1.4	2.3	2.7	-1.5	-1.6	1.5	1.5	1.5	-1.6	1.3	-1.5	-1.5
Intermittent access day 15 total infusions	0.8	1.1	1.6	-1.1	-1.3	1.1	1.0	1.0	-1.1	1.1	-0.9	-0.8
Intermittent access terminal intake (last 3 days)	1.2	1.5	2.1	-1.3	-1.4	1.2	1.2	1.2	-1.3	1.3	-1.1	-1.0
Intermittent access total infusions	2.6	3.0	3.8	-1.7	-1.9	1.7	1.7	1.7	-1.8	1.8	-1.7	-1.6
Intermittent access day 1 locomotion	0.5	0.6	0.9	-0.6	-0.9	0.6	0.6	0.7	-0.7	0.9	-0.8	-0.9
Intermittent access day 15 total locomotion	0.2	0.3	0.5	-0.5	-0.7	0.5	0.5	0.5	-0.5	0.6	-0.5	-0.5
Intermittent access total locomotion	1.9	2.3	3.2	-1.4	-1.8	1.4	1.4	1.4	-1.5	1.7	-1.5	-1.5
Intermittent access standard deviation	0.1	0.2	0.3	0.4	0.1	-0.4	-0.5	-0.5	0.4	-0.1	0.4	0.4
Left kidney weight	5.8	27.0	28.4	-5.1	-5.2	5.0	5.3	5.3	-5.2	5.2	-5.2	-5.2
Right kidney weight	5.3	24.2	25.7	-4.8	-5.0	4.8	4.9	4.9	-4.9	5.1	-4.9	-4.9
Cocaine induced anxiety	0.3	0.4	0.7	0.6	0.6	-0.5	-0.6	-0.6	0.5	-0.8	0.7	0.8
Post-drug Anxiety	0.1	0.1	0.3	0.3	0.4	-0.1	-0.3	-0.3	0.3	-0.6	0.4	0.5
Baseline Anxiety	0.0	0.0	0.0	-0.0	0.1	0.1	0.0	0.0	0.0	0.0	-0.1	-0.2
Tail length	0.3	1.1	1.4	-1.1	-1.0	1.1	1.2	1.2	-1.0	0.9	-0.9	-0.9
Length with tail	0.3	1.4	1.8	-1.2	-1.1	1.2	1.3	1.3	-1.2	1.2	-1.1	-1.0
Length without tail	0.5	1.5	2.4	-1.2	-1.4	1.0	1.2	1.2	-1.3	1.5	-1.1	-0.9
Times rat made contact with spout	0.0	0.0	0.1	0.0	-0.2	-0.2	0.1	0.1	-0.1	0.3	-0.2	-0.3
Lifetime Intake	2.4	2.9	3.6	-1.7	-1.9	1.7	1.7	1.7	-1.8	1.7	-1.7	-1.6
Liver weight, left	1.8	3.0	3.8	-1.9	-1.5	1.9	1.7	1.7	-1.7	1.5	-1.8	-1.8
Liver weight, right	1.4	2.5	3.4	-1.5	-1.6	1.3	1.7	1.6	-1.6	1.9	-1.5	-1.5
Locomotor activity	1.7	2.6	3.9	-1.8	-1.4	2.0	1.8	1.8	-1.5	1.1	-1.5	-1.6
Locomotor testing distance	0.9	1.6	2.4	-1.4	-1.1	1.5	1.4	1.4	-1.2	0.8	-1.1	-1.1
Locomotor testing rearing	3.8	7.7	8.8	-2.8	-2.8	3.0	2.8	2.8	-2.8	2.5	-2.7	-2.7
Locomotion in novel chamber	0.1	0.2	0.3	0.4	0.4	-0.3	-0.4	-0.4	0.5	-0.5	0.5	0.5
Locomotion in novel chamber post-restriction	0.9	1.4	1.9	1.1	1.3	-1.3	-1.1	-1.1	1.2	-1.4	1.2	1.2
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	-0.2	-0.2	0.2	0.1	0.1	-0.1	0.3	-0.1	-0.1
Change in fecal boli incidents, locomotor task	0.8	0.8	1.2	0.8	1.1	-0.9	-0.9	-0.9	0.9	-0.7	0.9	0.9
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.1	-0.2	-0.1	0.1	0.1	-0.2	-0.1	-0.1	-0.1
Bouts of movement, locomotor time 1	2.1	2.4	2.8	1.7	1.4	-1.7	-1.6	-1.6	1.5	-1.5	1.5	1.6
Total resting periods, locomotor time 1	2.9	3.3	3.6	1.9	1.7	-1.9	-1.8	-1.8	1.7	-1.8	1.8	1.9
Rest time, locomotor task time 1	0.1	0.2	0.3	0.5	0.3	-0.5	-0.4	-0.4	0.4	-0.2	0.4	0.5
Distance moved, locomotor task time 1	0.4	0.6	1.1	-0.8	-0.7	0.8	0.7	0.7	-0.6	1.0	-0.8	-0.8
Vertical activity count, locomotor time 1	0.0	0.0	0.1	0.1	0.2	-0.0	-0.1	-0.1	0.2	0.1	0.0	-0.1
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.1	0.2	-0.0	-0.2	-0.4	-0.3	0.2	-0.2	0.1	0.0
Bouts of movement, locomotor time 2	4.0	6.4	7.3	2.7	2.3	-2.7	-2.5	-2.5	2.5	-2.2	2.6	2.7
Total resting periods, locomotor time 2	3.2	5.7	6.5	2.5	2.2	-2.5	-2.4	-2.4	2.3	-2.1	2.4	2.5
Rest time, locomotor task time 2	0.0	0.1	0.3	0.3	0.5	-0.3	-0.1	-0.1	0.2	-0.3	0.1	0.1
Distance moved, locomotor task time 2	1.0	1.2	2.3	-1.0	-1.3	1.0	0.9	0.9	-0.9	1.5	-1.0	-1.0
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.3	0.1	-0.2	-0.4	-0.4	0.4	0.1	0.4	0.3
Light reinforcement 1	0.1	0.4	0.8	-0.4	-0.9	0.3	0.6	0.6	-0.6	0.6	-0.6	-0.6
Light reinforcement 2	0.1	0.1	0.2	-0.3	-0.3	0.3	0.4	0.4	-0.3	0.3	-0.2	-0.1
Bone: marrow area	0.0	0.0	0.1	0.3	-0.1	-0.2	-0.0	-0.0	0.0	0.2	0.0	0.0
Bone: maximum diameter	2.0	3.7	4.6	-1.9	-1.8	2.0	2.0	1.9	-1.9	2.1	-1.8	-1.7
Bone: maximum force	0.2	0.3	0.4	-0.6	-0.7	0.6	0.6	0.6	-0.6	0.5	-0.6	-0.5
Bone: maximum moment	0.3	0.4	0.6	-0.7	-0.8	0.7	0.6	0.6	-0.7	0.5	-0.7	-0.7
Mean time between licks in bursts	0.0	0.1	0.1	0.0	0.3	-0.3	-0.4	-0.3	0.3	-0.2	0.2	0.1
Mean num. licks in bursts	1.4	2.2	4.7	2.0	1.1	-2.2	-1.3	-1.3	1.4	-1.3	1.2	1.1
Cd content in liver	0.0	0.1	0.2	0.3	-0.3	-0.3	0.1	0.0	-0.1	0.4	-0.1	0.0
Co content in liver	1.2	1.4	1.7	1.2	1.2	-1.2	-1.3	-1.3	1.2	-1.1	1.0	0.9
Cu content in liver	0.2	0.2	0.5	-0.7	-0.3	0.7	0.5	0.5	-0.4	0.4	-0.3	-0.3
Fe content in liver	3.7	4.4	6.5	-2.5	-1.9	2.5	2.2	2.2	-2.1	2.0	-1.7	-1.7
K content in liver	0.1	0.1	0.2	-0.4	0.1	0.5	0.0	0.0	-0.1	0.0	-0.1	-0.2
Mg content in liver	0.4	0.4	0.6	-0.7	-0.4	0.8	0.4	0.5	-0.5	0.6	-0.7	-0.8
Mn content in liver	1.3	1.5	3.1	-1.0	-1.1	1.0	1.0	1.1	-1.1	1.1	-1.5	-1.7
Na content in liver	0.1	0.1	0.4	-0.6	-0.2	0.6	0.2	0.2	-0.3	0.3	-0.3	-0.3
Rb content in liver	0.2	0.2	0.7	-0.3	-0.4	0.3	0.5	0.5	-0.4	0.8	-0.4	-0.3
Se content in liver	2.8	3.4	4.9	-2.2	-1.5	2.2	1.8	1.9	-1.7	1.5	-1.8	-1.8
Sr content in liver	0.0	0.0	0.0	-0.2	0.1	0.2	0.0	0.1	0.0	-0.2	-0.1	-0.1
Zn content in liver	0.8	0.9	1.1	-1.0	-0.9	1.0	0.8	0.8	-0.9	1.0	-0.9	-0.9
Bone: minimum diameter	0.2	0.4	0.6	-0.6	-0.7	0.6	0.7	0.7	-0.7	0.7	-0.6	-0.6
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.4	-0.5	0.5	0.4	0.4	-0.4	0.3	-0.4	-0.4
Time in novel zone, hab. session 1	0.6	0.6	0.9	-0.8	-0.9	0.8	0.6	0.6	-0.8	0.9	-0.8	-0.8
Total zone transitions, hab. session 1	0.2	0.3	0.5	-0.4	-0.7	0.4	0.7	0.7	-0.6	0.5	-0.6	-0.5
Total locomotion distance, hab. session 1	0.4	0.6	1.0	0.7	0.8	-0.7	-0.7	-0.7	0.8	-1.0	0.8	0.8
Locomotion velocity, hab. session 1	1.3	1.8	2.5	1.3	1.4	-1.3	-1.2	-1.3	1.3	-1.6	1.4	1.4
Time in familiar zone, hab. session 2	0.1	0.1	0.4	-0.6	-0.3	0.5	0.4	0.3	-0.4	0.2	-0.1	-0.0
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2	-0.2	-0.0	0.3	-0.1	-0.1
Total zone transitions, hab. session 2	0.5	0.6	0.8	-0.6	-0.7	0.8	0.7	0.8	-0.7	0.7	-0.8	-0.9
Total locomotion distance, hab. session 2	0.6	0.8	0.9	0.9	0.9	-0.8	-0.9	-0.9	0.9	-1.0	0.8	0.8
Locomotion velocity, hab. session 2	0.4	0.5	0.7	0.7	0.7	-0.7	-0.7	-0.7	0.7	-0.8	0.6	0.5
Novel to familiar place preference ratio	1.2	1.4	2.2	-0.7	-1.4	0.7	1.3	1.3	-1.2	1.5	-1.2	-1.1
Novelty place preference	1.2	1.3	2.0	-0.7	-1.3	0.7	1.2	1.2	-1.1	1.4	-1.1	-1.1
Time in novel zone, NPP test	1.4	1.5	2.4	-0.8	-1.5	0.8	1.2	1.2	-1.3	1.5	-1.3	-1.2
Total zone transitions, NPP test	0.1	0.1	0.2	-0.5	-0.2	0.4	0.4	0.4	-0.3	0.2	-0.2	-0.2
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.4	-0.3	0.4	0.4	0.4	-0.3	0.2	-0.2	-0.2
Locomotion velocity, NPP test	0.0	0.1	0.2	-0.3	-0.0	0.3	0.4	0.4	-0.2	0.2	-0.1	-0.1
Intraocular pressure	0.0	0.0	0.2	0.1	-0.4	-0.0	-0.1	-0.2	-0.2	0.3	-0.1	0.0
Delta distance traveled before/after self-admin	2.0	2.1	2.6	1.4	1.4	-1.4	-1.4	-1.4	1.5	-1.6	1.4	1.4
Delta ambulatory time before/after self-admin	0.4	0.5	0.9	0.7	0.7	-0.7	-0.7	-0.7	0.7	-0.9	0.6	0.6
Parametrial fat weight	0.1	0.2	0.3	-0.3	-0.5	0.5	0.3	0.3	-0.3	0.2	-0.5	-0.5
Pavlov. Cond. lever latency	0.5	0.6	0.7	0.5	0.7	-0.7	-0.8	-0.9	0.7	-0.9	0.8	0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.1	-0.4	0.2	0.3	0.3	-0.3	0.5	-0.2	-0.1
Pavlov. Cond. change in total contacts	0.5	0.5	0.9	1.0	0.6	-0.9	-0.7	-0.7	0.7	-0.4	0.6	0.6
Pavlov. Cond. index score	0.2	0.3	0.5	-0.3	-0.6	0.5	0.5	0.6	-0.5	0.7	-0.5	-0.5
Pavlov. Cond. latency score	0.0	0.0	0.1	0.0	-0.2	0.2	0.2	0.2	-0.2	0.3	-0.2	-0.2
Pavlov. Cond. lever contacts	0.3	0.3	0.4	-0.4	-0.5	0.5	0.6	0.7	-0.5	0.7	-0.6	-0.6
Pavlov. Cond. magazine entry number	0.0	0.0	0.2	-0.1	0.3	0.0	-0.0	-0.1	0.1	-0.4	0.1	0.0
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.5	-0.3	-0.4	0.3	0.3	0.4	-0.4	0.4	-0.6	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.5	-0.4	-0.6	0.5	0.6	0.6	-0.6	0.7	-0.6	-0.7
Pavlov. Cond. response bias	0.9	1.1	1.7	-0.8	-1.1	0.9	1.1	1.1	-1.0	1.3	-1.0	-0.9
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.2	0.2	-0.2	0.1	0.0	0.2	-0.2	0.1	0.1
Pavlov. Cond. magazine entry latency	0.3	0.3	1.2	-0.0	-1.1	0.0	0.2	0.2	-0.7	0.9	-0.6	-0.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.4	-0.2	-0.5	-0.5	-0.5	0.1	0.2	0.2	0.3
Pavlov. Cond. index score	0.1	0.1	0.3	0.1	-0.6	-0.2	-0.1	-0.1	-0.3	0.5	-0.1	-0.0
Pavlov. Cond. latency score	0.0	0.1	0.1	0.2	-0.4	-0.3	-0.3	-0.2	-0.1	0.3	0.0	0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.3	-0.4	0.3	0.2	0.2	-0.4	0.5	-0.3	-0.2
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	-0.7	0.3	0.7	0.6	0.6	-0.1	-0.2	-0.3	-0.5
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.3	-0.2	0.5	0.1	0.1	0.1	0.2	-0.3	0.1	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.5	-0.1	-0.7	-0.0	0.1	0.1	-0.4	0.6	-0.3	-0.2
Pavlov. Cond. response bias	0.0	0.1	0.2	0.1	-0.4	-0.1	-0.1	-0.1	-0.2	0.4	-0.2	-0.1
Time in closed arm before self-admin	0.9	1.1	1.3	-1.1	-1.0	1.0	1.1	1.1	-1.1	1.2	-1.0	-0.9
Time in closed arm after self-admin	0.8	0.9	1.5	0.8	0.8	-0.9	-0.8	-0.8	0.8	-1.0	1.1	1.2
Time in open arm before self-admin	0.9	1.0	1.2	1.1	0.9	-0.9	-1.0	-1.0	1.0	-1.1	0.9	0.8
Time in open arm after self-admin	0.1	0.1	0.3	0.5	0.4	-0.3	-0.4	-0.4	0.5	-0.3	0.1	-0.0
Bone: periosteal estimation	0.3	0.6	0.9	-0.6	-0.8	0.7	0.9	0.8	-0.8	0.9	-0.7	-0.7
Bone: periosteal perimeter	0.2	0.3	0.5	-0.5	-0.5	0.6	0.6	0.6	-0.6	0.7	-0.5	-0.4
Bone: post-yield work	0.7	1.0	1.3	1.0	0.9	-1.1	-0.9	-0.9	0.9	-0.8	1.1	1.2
Progressive ratio test 1 active lever presses	2.4	3.0	3.4	-1.8	-1.6	1.8	1.8	1.8	-1.7	1.5	-1.8	-1.8
Progressive ratio test 1 breakpoint	2.2	2.7	3.1	-1.7	-1.5	1.7	1.7	1.7	-1.6	1.4	-1.7	-1.7
Progressive ratio test 1 inactive lever presses	1.2	1.8	2.0	-1.4	-1.4	1.4	1.3	1.3	-1.4	1.3	-1.3	-1.2
Progressive ratio test 2 active lever presses	2.0	2.3	2.8	-1.6	-1.5	1.7	1.5	1.5	-1.5	1.6	-1.4	-1.3
Progressive ratio test 2 breakpoint	2.2	2.6	3.1	-1.7	-1.6	1.7	1.6	1.6	-1.6	1.7	-1.5	-1.4
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.4	-0.3	0.5	0.3	0.3	-0.4	0.5	-0.2	-0.1
Incentive Sensitization - Responses	1.0	1.5	2.6	-1.2	-1.3	1.3	1.1	1.1	-1.3	1.6	-1.0	-0.9
Incentive Sensitization - Breakpoint	1.0	1.3	2.3	-1.1	-1.2	1.2	1.1	1.0	-1.2	1.5	-0.9	-0.7
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.6	0.5	0.6	-0.5	-0.5	-0.5	0.6	-0.7	0.4	0.4
Progressive ratio	1.3	2.0	2.7	1.3	1.5	-1.4	-1.2	-1.2	1.4	-1.5	1.6	1.7
Food seeking constrained by brief footshock	4.5	5.5	6.7	2.6	2.2	-2.5	-2.4	-2.4	2.5	-2.2	2.2	2.0
Seeking ratio, punishment vs. effort	0.3	0.5	0.8	0.9	0.6	-0.8	-0.9	-0.8	0.7	-0.5	0.5	0.4
Retroperitoneal fat weight	0.0	0.0	0.2	-0.3	-0.1	0.4	0.3	0.2	-0.2	0.0	-0.0	0.0
Reaction time number correct	4.2	8.1	10.0	-3.0	-3.2	2.8	2.8	2.8	-2.9	2.5	-2.8	-2.8
Reaction time mean minus median	0.0	0.1	0.2	0.4	0.1	-0.3	-0.3	-0.2	0.1	0.3	0.2	0.3
Reaction time mean minus median AUC	0.1	0.3	1.1	-0.3	-0.7	0.4	0.5	0.5	-0.6	1.1	-0.5	-0.4
Reaction time num false alarms	4.3	6.1	7.4	-2.5	-2.5	2.4	2.5	2.5	-2.5	2.7	-2.4	-2.3
Reaction time num false alarms AUC	3.2	5.1	6.0	-2.3	-2.2	2.3	2.3	2.3	-2.3	2.5	-2.2	-2.1
Reaction time trials correct on left	4.2	8.1	10.0	-3.0	-3.2	2.8	2.8	2.8	-2.9	2.5	-2.8	-2.8
Reaction time trials on left	4.3	8.1	10.1	-3.0	-3.2	2.8	2.8	2.8	-2.9	2.5	-2.9	-2.8
Reaction time mean	0.7	1.2	2.5	1.6	0.8	-1.4	-1.2	-1.1	1.0	-0.5	0.9	0.9
Reaction time mean AUC	0.5	0.8	1.9	1.4	0.7	-1.2	-0.9	-0.9	0.8	-0.4	0.8	0.8
Median of all reaction times	1.1	1.5	3.1	1.8	0.9	-1.6	-1.3	-1.3	1.1	-0.8	1.0	1.0
Reaction time omissions	0.1	0.2	0.5	0.1	-0.5	-0.1	0.1	0.2	-0.3	0.7	-0.4	-0.4
Reaction time false alarm rate	0.1	0.1	0.4	-0.3	-0.2	0.3	0.3	0.3	-0.3	0.7	-0.2	-0.2
Reaction time premature initiation rate	0.4	0.5	0.8	0.9	0.8	-0.9	-0.7	-0.7	0.8	-0.6	0.7	0.6
Reaction time premature initiations	0.3	0.6	0.7	-0.7	-0.8	0.6	0.8	0.8	-0.7	0.7	-0.8	-0.8
Std. dev. reaction times	0.1	0.2	0.5	0.7	0.3	-0.5	-0.5	-0.5	0.4	0.0	0.4	0.4
Reaction time trials completed	4.3	8.1	10.1	-3.0	-3.2	2.8	2.8	2.8	-2.9	2.5	-2.9	-2.8
Reaction time trials AUC	5.2	9.9	12.3	-3.3	-3.5	3.1	3.1	3.1	-3.2	2.8	-3.2	-3.1
Run reversals in cocaine runway, females	0.3	0.3	0.6	0.5	0.7	-0.5	-0.5	-0.5	0.5	-0.4	0.7	0.8
Run reversals in cocaine runway, males	0.6	0.6	0.8	-0.9	-0.7	0.7	0.7	0.7	-0.7	0.7	-0.8	-0.8
Latency to leave start box in cocaine runway	0.1	0.1	0.4	-0.4	-0.4	0.1	0.6	0.6	-0.4	0.3	-0.2	-0.1
Latency to leave start box in cocaine runway, F	0.7	0.8	1.1	-1.0	-0.8	0.8	1.1	1.1	-0.9	0.8	-0.8	-0.8
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.3	0.1	-0.4	-0.1	-0.1	0.1	-0.2	0.4	0.5
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.1	-0.2	-0.0	0.4	0.4	-0.2	0.3	-0.2	-0.3
Total sessions with >9 infusions	3.7	4.5	4.8	-2.2	-2.2	2.1	2.1	2.1	-2.1	2.0	-2.1	-2.2
Short access day 1 total inactive lever presses	0.4	0.5	0.7	-0.7	-0.8	0.8	0.7	0.7	-0.8	0.8	-0.6	-0.5
Short access day 10 total inactive lever presses	0.6	1.4	1.7	1.2	1.0	-1.1	-1.2	-1.3	1.2	-0.8	1.3	1.3
Short access day 1 total infusions	1.8	2.4	2.5	-1.6	-1.5	1.6	1.6	1.6	-1.5	1.5	-1.6	-1.6
Short access day 10 total infusions	3.6	4.7	5.0	-2.2	-2.2	2.1	2.1	2.2	-2.2	2.0	-2.2	-2.2
Short access total infusions	2.1	2.7	2.9	-1.7	-1.7	1.7	1.6	1.6	-1.6	1.5	-1.7	-1.7
Short access day 1 locomotion	3.2	4.0	4.5	-2.0	-2.1	2.0	2.0	2.0	-2.0	1.8	-2.0	-2.0
Short access day 10 total locomotion	0.1	0.2	0.7	-0.1	-0.7	0.0	0.1	0.2	-0.3	0.9	-0.5	-0.5
Short access total locomotion	1.1	1.3	1.9	-1.0	-1.4	0.9	1.0	1.1	-1.0	1.2	-1.3	-1.4
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.2	-0.3	0.2	0.2	0.2	-0.3	0.4	-0.1	-0.0
Compulsive drug intake	0.3	0.4	0.6	-0.6	-0.4	0.5	0.6	0.7	-0.6	0.8	-0.7	-0.7
One hour access (shock baseline)	0.8	1.2	1.5	-1.1	-1.2	1.1	1.1	1.1	-1.2	1.1	-1.0	-0.9
Social response proportion	1.7	1.9	3.1	-1.1	-1.7	1.0	1.4	1.4	-1.5	1.5	-1.4	-1.4
Social responses	1.1	1.4	1.8	-1.0	-1.3	1.0	1.2	1.2	-1.2	1.3	-1.1	-1.1
Social time	3.2	4.4	4.9	2.2	2.2	-2.1	-2.0	-2.0	2.1	-1.8	2.2	2.2
Soleus weight	0.1	0.3	0.6	-0.6	-0.4	0.6	0.8	0.7	-0.5	0.5	-0.1	0.0
Bone: stiffness	0.7	1.1	1.6	-1.2	-1.1	1.3	1.1	1.1	-1.1	1.0	-0.9	-0.8
Tibialis anterior weight	3.1	10.5	13.2	-3.3	-3.2	3.3	3.6	3.6	-3.3	3.1	-2.9	-2.8
Time to tail flick, vehicle, before self-admin	3.1	3.2	4.3	-1.7	-1.8	1.8	1.8	1.8	-1.7	1.4	-2.0	-2.1
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.1	-0.2	0.2	0.1	0.1	-0.2	0.1	0.1	0.3
Time to tail flick, test, before self-admin	0.4	0.4	0.6	0.8	0.6	-0.7	-0.7	-0.6	0.7	-0.4	0.4	0.2
Time to tail flick, test, after self-admin	0.2	0.2	0.2	0.5	0.4	-0.4	-0.4	-0.5	0.4	-0.5	0.4	0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	0.3	0.3	-0.3	-0.3	-0.4	0.3	-0.2	0.5	0.6
Delta time to tail flick, test, before/after SA	0.7	0.8	1.0	-1.0	-0.9	1.0	1.0	0.9	-0.9	0.7	-0.7	-0.7
Tibia length	0.2	0.6	1.0	-0.7	-0.8	0.6	0.7	0.7	-0.9	0.9	-1.0	-1.0
Ambulatory time before self-admin	0.0	0.0	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.0	0.1	0.1	0.1
Ambulatory time after self-admin	0.4	0.5	0.7	0.7	0.8	-0.7	-0.7	-0.7	0.7	-0.8	0.7	0.6
Bone: tissue strength	0.6	0.6	0.9	1.0	0.6	-0.9	-0.9	-0.9	0.8	-0.8	0.6	0.6
Total heroin consumption	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.1	0.1	0.0	0.1	0.1
Bone: trabecular number	0.0	0.0	0.1	0.3	0.1	-0.3	-0.0	-0.0	0.1	-0.1	0.1	0.2
Bone: trabecular spacing	0.0	0.0	0.1	-0.3	-0.1	0.3	0.0	0.0	-0.1	0.1	-0.1	-0.2
Bone: trabecular thickness	1.6	2.0	2.2	-1.3	-1.4	1.3	1.5	1.5	-1.4	1.5	-1.4	-1.4
Bone: trabecular tissue density	0.3	0.4	0.6	-0.7	-0.6	0.6	0.7	0.7	-0.7	0.8	-0.6	-0.6
Water consumed over 24 hours	0.1	0.1	0.2	0.4	-0.2	-0.5	-0.1	-0.1	0.1	0.2	-0.2	-0.3
Number of responses in last shaping day	2.9	3.2	3.5	-1.9	-1.7	1.8	1.8	1.8	-1.9	1.8	-1.8	-1.7