Hub : Genes

Apod

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Apod 0.24 0.13 7.1e-03 0.05 0.03 0.06 0.08 2.6e-02 5.2e-02 1.6e-02 6.3e-03
2 RMTg gene expression Apod 0.24 0.1 6.8e-05 0.18 0.15 0.16 0.15 1.7e-05 8.8e-05 3.9e-05 6.5e-05
3 PL gene expression Apod 0.12 0.04 2.2e-14 0.11 0.14 0.13 0.13 3.2e-12 1.2e-14 4.1e-14 9.1e-14
4 PL mRNA stability Apod 0.06 0.03 4.3e-07 0.05 0.06 0.05 0.05 1.8e-06 6.1e-07 4.7e-06 3.2e-06
5 Brain mRNA stability Apod 0.32 0.09 1.6e-14 0.13 0.16 0.18 0.17 1.8e-12 4.0e-15 3.2e-16 6.0e-16
6 pVTA mRNA stability Apod 0.12 0.06 6.2e-04 0.03 0.06 0.06 0.06 2.3e-02 1.7e-03 1.3e-03 1.8e-03
7 BLA mRNA stability Apod 0.1 0.05 1.2e-05 0.07 0.1 0.08 0.08 1.3e-04 3.3e-06 6.8e-05 4.2e-05
8 Brain gene expression Apod 0.39 0.07 0.0e+00 0.41 0.4 0.41 0.42 1.2e-40 1.3e-39 6.4e-41 8.6e-42
9 NAcc mRNA stability Apod 0.18 0.07 0.0e+00 0.12 0.19 0.19 0.19 3.8e-14 2.1e-21 4.3e-21 2.1e-21
10 NAcc gene expression Apod 0.23 0.06 0.0e+00 0.28 0.28 0.3 0.31 3.2e-33 3.5e-33 9.8e-36 2.4e-36
11 pVTA gene expression Apod 0.36 0.09 7.4e-15 0.35 0.32 0.31 0.33 7.3e-16 1.9e-14 7.6e-14 7.7e-15
12 BLA gene expression Apod 0.21 0.09 1.5e-08 0.14 0.1 0.07 0.12 7.4e-08 3.9e-06 8.6e-05 3.9e-07
13 LHb gene expression Apod 0.57 0.12 1.5e-09 0.22 0.3 0.27 0.29 5.4e-06 6.9e-08 3.3e-07 1.4e-07
14 OFC gene expression Apod 0.16 0.1 7.7e-03 0.13 0.08 0.09 0.1 5.8e-04 5.3e-03 3.2e-03 3.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density8.213.726.9-5.24.0-4.3-4.03.63.2-2.5-4.0-3.4-3.73.62.0-3.83.6
Area under the delay curve0.20.21.30.40.20.1-0.2-1.10.2-0.5-0.1-0.0-0.30.20.70.20.2
BMI with tail0.10.32.40.8-1.60.30.70.2-0.30.30.10.0-0.10.2-0.0-0.40.2
BMI without tail0.40.83.81.9-2.01.10.9-0.5-0.30.10.80.20.8-0.5-0.10.6-0.4
Body weight0.31.23.00.6-1.2-0.7-0.71.11.4-1.7-0.9-1.3-1.01.20.9-0.41.2
Weight adjusted by age0.70.82.20.60.50.81.1-1.5-1.21.30.41.20.1-0.80.8-0.5-0.5
Bone surface5.29.213.9-3.73.6-3.4-3.12.42.3-2.0-3.4-2.6-3.43.02.4-3.53.0
Bone volume6.210.616.7-4.13.7-3.6-3.42.82.7-2.2-3.6-2.9-3.53.22.4-3.63.3
Breakpoint value in progressive ratio session1.21.35.90.9-1.5-0.5-0.91.21.5-2.4-0.2-1.8-0.00.50.11.10.4
Number of licking bursts0.30.41.6-1.01.3-0.5-0.80.20.7-0.3-0.5-0.5-0.40.40.4-0.60.4
Context. condit. distance diff. score0.30.41.1-0.1-0.4-0.6-0.70.71.0-0.9-0.5-0.8-0.30.50.10.20.5
Locomotion velocity, session 12.52.75.41.8-1.01.72.2-1.7-2.32.01.52.31.0-1.4-0.40.4-1.4
Locomotion distance, session 11.31.75.42.3-2.31.21.2-1.3-0.90.11.20.81.2-0.9-0.51.3-0.9
Locomotion velocity, session 21.41.63.31.1-1.81.01.3-0.1-0.90.81.50.91.5-1.3-1.71.5-1.4
Locomotion distance, session 20.60.82.71.6-1.61.11.1-0.8-0.80.60.80.60.8-0.5-0.20.5-0.5
Locomotion velocity, session 30.40.41.61.2-1.00.80.7-0.6-0.30.20.50.40.6-0.30.00.7-0.3
Locomotion distance, session 30.10.10.70.9-0.70.40.30.0-0.0-0.30.2-0.10.3-0.00.20.6-0.1
Stereotopy head waving bouts, day 30.50.62.41.0-0.01.11.0-1.5-0.70.90.50.90.3-0.40.40.3-0.3
Stereotopy head waving duration, day 30.81.03.71.30.01.21.1-1.9-1.11.00.61.30.3-0.60.60.3-0.5
Locomotion velocity, session 71.31.43.82.0-1.41.71.3-1.2-1.00.71.20.71.4-0.9-0.31.1-0.9
Locomotion distance, session 71.92.45.82.4-2.02.01.7-1.0-1.31.01.71.01.8-1.4-0.81.4-1.4
Stereotopy head waving bouts, day 70.20.31.00.20.30.50.5-0.8-0.61.00.10.90.0-0.10.4-0.5-0.1
Stereotopy head waving duration, day 70.20.21.10.20.50.30.3-1.0-0.30.60.00.8-0.1-0.10.6-0.4-0.1
Locomotion velocity, session 80.20.20.90.1-0.4-0.2-0.3-0.10.7-0.2-0.5-0.4-0.40.70.5-0.90.6
Locomotion distance, session 80.30.51.91.4-1.40.70.5-0.3-0.0-0.10.60.00.6-0.3-0.20.9-0.3
Degree of sensitization distance0.91.01.41.2-1.11.21.1-0.6-0.90.91.10.81.2-1.0-0.80.7-1.0
Degree of sensitization stereotypy0.10.10.3-0.20.1-0.00.10.2-0.20.5-0.20.4-0.10.20.1-0.50.1
Conditioned locomotion0.20.20.80.10.1-0.2-0.4-0.20.6-0.6-0.5-0.4-0.50.60.9-0.60.6
Cocaine response after cond. corrected0.30.42.40.3-1.6-0.3-0.30.30.8-0.80.1-0.70.40.0-0.80.20.0
Cocaine response after cond. not corrected0.60.63.30.5-1.80.1-0.10.20.6-0.70.5-0.50.8-0.4-1.30.9-0.4
Cocaine response before conditioning0.40.51.40.8-0.20.90.8-0.6-0.50.50.90.50.7-0.8-0.31.2-0.8
Saline control response0.40.52.6-0.81.60.00.4-0.2-0.81.2-0.10.8-0.5-0.20.3-1.0-0.2
Bone: connectivity density4.87.521.6-4.63.9-3.3-2.83.01.7-1.2-2.7-2.2-2.62.10.8-2.92.1
Bone: cortical apparent density0.20.21.50.6-1.20.40.6-0.2-0.30.40.30.40.4-0.1-0.4-0.0-0.1
Bone: cortical area0.91.32.6-0.3-0.7-0.9-0.91.30.9-1.1-1.3-1.3-1.11.61.0-1.31.6
Bone: cortical porosity0.10.10.5-0.1-0.40.50.30.40.00.70.30.20.5-0.3-0.7-0.0-0.2
Bone: cortical porosity0.20.21.1-0.10.30.60.5-0.2-0.41.00.30.60.2-0.3-0.1-0.4-0.3
Bone: cortical thickness0.61.01.6-0.9-0.2-1.0-0.91.20.8-0.7-1.2-1.1-0.81.30.5-1.31.3
Bone: cortical thickness2.02.34.2-2.11.0-2.0-1.81.81.3-1.2-1.6-1.3-1.41.40.4-1.61.5
Bone: cortical tissue density0.20.31.40.7-1.20.60.7-0.4-0.40.50.30.40.4-0.2-0.30.0-0.2
Condit. Reinf. active minus inactive responses1.21.33.4-1.70.8-1.6-1.31.81.0-0.9-1.1-1.1-0.90.8-0.1-0.90.8
Condit. Reinf. active-inactive response ratio0.70.72.3-1.50.5-1.3-1.01.50.8-0.6-0.5-0.6-0.20.1-0.9-0.20.1
Condit. Reinf. active responses1.01.21.8-1.30.9-1.3-1.11.30.9-0.8-1.3-1.0-1.11.20.7-1.31.1
Condit. Reinf. inactive responses0.91.04.30.10.6-0.2-0.3-0.30.4-0.4-1.2-0.6-1.21.52.1-1.41.4
Incentive salience index mean1.01.22.7-1.60.9-1.4-1.11.70.8-0.8-1.2-1.1-0.91.00.3-1.11.0
Condit. Reinf. lever presses0.10.10.3-0.10.0-0.10.10.4-0.20.0-0.4-0.3-0.30.60.5-0.40.5
Condit. Reinf. active minus inactive responses0.60.71.5-1.20.9-0.9-0.71.10.3-0.1-0.9-0.5-0.70.90.5-1.20.9
Condit. Reinf. active-inactive response ratio0.80.81.4-0.60.1-0.7-0.91.01.0-0.9-1.0-1.1-0.61.20.8-0.91.2
Condit. Reinf. active responses0.40.61.5-1.20.9-0.8-0.41.2-0.00.1-0.8-0.3-0.60.70.3-1.10.7
Condit. Reinf. inactive responses0.20.20.6-0.80.6-0.30.20.7-0.60.6-0.00.3-0.1-0.2-0.5-0.3-0.1
Condit. Reinf. lever presses1.82.43.7-1.91.9-1.7-1.61.31.0-1.1-1.7-1.3-1.71.61.4-1.41.6
Condit. Reinf. lever reinforcers received0.71.02.5-1.61.5-1.1-0.81.20.1-0.0-1.1-0.4-1.00.90.6-1.40.9
Conditioned reinforcement - actives0.10.10.60.4-0.6-0.1-0.30.30.2-0.8-0.1-0.20.10.20.40.70.2
Conditioned reinforcement - inactives0.60.72.1-0.90.4-0.9-1.01.51.0-0.8-0.7-0.9-0.60.90.2-0.40.6
Conditioned locomotion0.10.10.50.20.00.00.00.20.10.1-0.10.50.00.20.7-0.30.1
Patch foraging indifference point 0 sec0.30.51.60.1-0.40.40.4-0.2-0.00.60.70.50.9-0.9-1.30.9-0.9
Patch foraging indifference point AUC2.22.64.32.0-1.02.12.1-1.6-2.01.91.61.81.5-1.3-0.30.9-1.4
Delay disc. indifference point, 0s delay0.20.20.8-0.1-0.7-0.3-0.40.30.9-0.6-0.1-0.50.20.1-0.70.40.1
Delay disc. indifference point, 16s delay0.40.41.41.2-1.10.50.4-1.0-0.2-0.40.50.10.5-0.3-0.11.1-0.3
Delay disc. indifference point, 2s delay0.10.10.70.2-0.4-0.1-0.1-0.90.4-0.40.2-0.00.1-0.2-0.30.5-0.2
Delay disc. indifference point, 24s delay0.50.51.40.9-0.20.80.9-1.1-1.20.50.50.60.3-0.50.30.6-0.4
Delay disc. indifference point, 4s delay0.50.51.3-0.40.9-0.5-0.7-0.70.7-0.6-0.8-0.4-0.70.81.1-0.70.8
Delay disc. indifference point, 8s delay0.20.31.10.10.6-0.2-0.4-0.70.3-0.6-0.4-0.2-0.50.41.0-0.10.4
Indifference point function ln k1.92.65.1-2.20.3-2.2-2.12.32.1-2.0-1.4-1.8-0.91.1-0.5-0.31.2
Indifference point function log k1.92.65.1-2.20.3-2.2-2.12.32.1-2.0-1.4-1.8-0.91.1-0.5-0.31.2
Patch foraging total patch changes 0 sec0.20.31.4-0.4-0.1-0.1-0.10.20.40.20.40.10.6-0.6-1.20.7-0.6
Patch foraging total patch changes 12 sec0.10.10.30.20.40.30.4-0.4-0.50.50.20.30.1-0.20.10.1-0.2
Patch foraging total patch changes 18 sec0.30.41.21.1-1.00.81.0-0.5-0.70.60.40.30.4-0.2-0.10.5-0.2
Patch foraging total patch changes 24 sec0.60.82.5-0.10.30.61.1-0.1-1.01.60.91.10.6-0.9-1.10.4-1.1
Patch foraging total patch changes 6 sec0.30.51.20.21.10.60.7-1.0-0.81.10.21.0-0.1-0.20.7-0.1-0.2
Patch foraging time to switch 0 sec1.42.24.3-1.21.4-1.1-0.91.00.7-0.6-1.7-1.2-2.12.01.9-2.01.8
Patch foraging water rate 0 sec0.50.92.2-1.00.0-1.2-1.50.71.5-1.4-0.8-1.1-0.10.5-0.40.20.6
Patch foraging water rate 12 sec0.30.42.3-0.3-0.3-0.10.10.1-0.10.10.60.30.6-0.9-1.51.1-0.9
Patch foraging water rate 18 sec1.11.55.5-0.3-1.5-0.6-0.71.21.2-1.40.5-0.91.2-0.5-2.22.4-0.6
Patch foraging water rate 24 sec1.21.65.0-1.2-0.0-1.8-1.60.91.6-2.2-1.0-2.0-0.50.8-0.40.70.9
Patch foraging water rate 6 sec2.33.36.7-2.60.6-2.6-2.52.42.3-2.3-1.3-2.3-0.80.9-1.10.10.9
Seeking ratio, delayed vs. immediate footshock1.82.16.60.90.21.51.8-2.1-2.62.01.11.80.6-1.10.10.4-1.1
Distance traveled before self-admin1.11.23.5-0.0-1.2-0.5-1.11.81.9-1.4-0.7-1.60.20.9-0.10.11.0
Distance traveled after self-admin0.20.20.80.4-0.60.70.4-0.0-0.00.30.4-0.10.9-0.4-0.50.9-0.3
Extensor digitorum longus weight0.31.14.81.0-0.50.40.3-0.5-0.10.2-0.9-0.1-1.21.52.2-1.31.5
Bone: elastic displacement0.20.21.00.1-0.3-0.1-0.4-0.00.8-0.80.1-0.50.3-0.1-0.41.0-0.1
Bone: elastic work0.50.71.2-0.40.6-0.6-0.80.60.8-0.7-1.0-0.8-1.01.01.1-0.81.0
Bone: endosteal estimation0.40.84.80.60.60.0-0.3-0.40.1-0.4-0.9-0.3-1.11.12.2-1.21.1
Bone: endosteal perimeter0.20.40.90.4-0.7-0.2-0.30.90.6-0.8-0.6-0.9-0.60.80.6-0.20.8
Epididymis fat weight0.41.06.61.1-2.6-0.3-0.40.51.2-1.6-0.2-1.10.30.4-0.30.30.6
Delta time in closed arm before/after self-admin0.30.30.60.3-0.30.40.4-0.6-0.40.60.70.60.5-0.8-0.80.2-0.7
Delta time in open arm before/after self-admin0.90.81.8-0.3-0.1-0.8-0.81.41.1-1.1-0.9-1.0-0.71.10.7-0.51.1
Diff in mean of infusions in LGA sessions0.10.20.60.7-0.7-0.1-0.20.10.2-0.80.2-0.6-0.00.10.00.0-0.1
Delay discount exponential model param0.20.21.5-0.5-0.2-0.2-0.01.20.10.20.0-0.10.1-0.1-0.6-0.4-0.0
Extinction: sum of active levers before priming2.02.05.81.4-2.41.10.80.10.2-0.11.6-0.12.1-1.2-2.02.1-1.3
Active lever presses in extinction session 61.51.43.8-0.5-0.1-1.3-1.61.41.6-2.0-0.9-1.8-1.00.90.5-0.40.9
Bone: final force0.91.53.1-0.20.0-0.9-0.71.00.5-0.7-1.5-0.9-1.61.71.7-1.71.8
Bone: final moment1.42.24.6-0.30.2-1.1-0.91.10.7-1.0-1.9-1.1-2.02.12.1-2.02.1
Food consumed during 24 hour testing period0.30.31.6-1.30.8-0.7-0.60.90.3-0.0-0.1-0.20.1-0.2-0.7-0.2-0.2
Glucose1.52.26.31.6-2.51.10.9-0.3-0.40.11.60.92.0-1.4-1.82.3-1.4
Heart weight0.20.21.01.0-0.70.10.1-1.00.5-0.70.10.1-0.10.00.20.30.0
Delay discount hyperbolic model param0.10.11.2-0.3-0.3-0.00.11.1-0.10.30.1-0.00.2-0.1-0.5-0.2-0.1
Intermittent access intake day 1-15 change1.81.83.2-1.01.2-1.2-1.31.40.7-1.3-1.7-1.0-1.51.81.7-0.51.8
Intermittent access intake escalation1.11.02.2-0.81.2-0.8-1.00.80.4-1.0-1.3-0.7-1.21.31.5-0.11.3
Intermittent access intake escalation 22.12.03.1-1.61.7-1.4-1.41.70.6-1.1-1.8-1.1-1.51.71.5-0.51.7
Intermitt. access day 1 inactive lever presses0.20.30.7-0.50.2-0.8-0.80.80.6-0.9-0.2-0.4-0.40.1-0.10.30.2
Intermitt. access day 15 inactive lever presses0.80.83.3-1.81.4-1.1-1.20.61.0-0.6-0.8-0.7-0.40.60.2-0.50.5
Intermitt. access escalation Index1.00.92.1-1.31.1-0.9-0.90.20.7-0.3-1.1-0.7-1.01.10.8-1.41.0
Intermittent access day 1 total infusions0.10.10.6-0.50.5-0.5-0.50.00.3-0.0-0.10.0-0.20.10.1-0.8-0.0
Intermittent access day 15 total infusions0.70.71.4-0.80.9-1.0-1.20.50.9-1.1-0.9-0.6-0.80.90.9-0.50.9
Intermittent access terminal intake (last 3 days)0.60.71.3-0.71.0-0.9-1.10.30.8-1.0-0.9-0.5-0.90.91.1-0.60.8
Intermittent access total infusions0.20.20.6-0.50.6-0.6-0.8-0.10.7-0.6-0.4-0.1-0.30.30.5-0.40.3
Intermittent access day 1 locomotion1.11.22.1-1.10.7-1.3-1.20.81.3-0.9-1.1-0.7-1.11.10.9-1.51.1
Intermittent access day 15 total locomotion2.52.75.8-1.92.4-1.9-1.70.91.1-0.9-1.6-0.8-2.21.51.8-2.11.1
Intermittent access total locomotion2.02.33.7-1.61.2-1.9-1.91.51.9-1.5-1.5-1.2-1.51.41.0-1.41.2
Intermittent access standard deviation0.30.31.5-0.41.2-0.3-0.5-0.20.4-0.6-0.50.2-0.60.31.00.20.3
Left kidney weight0.51.56.82.6-1.91.71.3-1.1-0.80.21.10.71.1-0.70.21.0-0.6
Right kidney weight0.20.42.31.5-1.00.80.5-1.00.0-0.20.40.30.40.00.50.4-0.0
Cocaine induced anxiety0.10.10.30.5-0.50.1-0.10.20.3-0.5-0.3-0.5-0.20.30.4-0.10.5
Post-drug Anxiety0.40.51.71.2-1.30.80.6-0.6-0.40.30.60.30.7-0.6-0.30.4-0.4
Baseline Anxiety0.10.10.4-0.40.1-0.00.0-0.3-0.20.60.30.30.4-0.4-0.6-0.2-0.4
Tail length0.20.72.51.0-0.9-0.0-0.70.01.4-1.6-0.3-1.1-0.00.50.60.50.6
Length with tail0.83.19.0-0.50.2-1.6-2.11.62.6-3.0-1.6-2.3-1.51.71.4-0.11.7
Length without tail1.02.23.9-1.41.1-1.8-1.31.71.1-1.5-1.7-1.3-2.01.61.2-1.01.6
Times rat made contact with spout0.80.93.5-1.91.6-1.0-1.20.91.2-0.4-0.6-1.0-0.40.3-0.4-0.40.3
Lifetime Intake0.10.20.6-0.40.8-0.5-0.5-0.00.2-0.1-0.30.2-0.50.10.4-0.60.1
Liver weight, left0.10.10.50.2-0.30.10.4-0.1-0.70.30.20.50.2-0.3-0.3-0.1-0.2
Liver weight, right0.10.21.20.8-1.10.40.40.3-0.3-0.10.1-0.00.30.20.10.10.2
Locomotor activity1.52.45.61.60.01.91.8-2.4-1.82.01.52.10.8-1.40.10.3-1.4
Locomotor testing distance3.15.112.62.00.62.52.5-3.6-2.73.02.13.11.1-2.2-0.00.3-2.2
Locomotor testing rearing0.20.41.4-0.10.80.40.6-0.7-0.81.20.20.9-0.3-0.30.1-0.5-0.2
Locomotion in novel chamber0.70.91.60.9-1.01.00.7-1.2-0.20.41.10.81.3-1.1-0.91.1-1.1
Locomotion in novel chamber post-restriction0.20.21.0-0.30.60.30.6-0.3-1.00.90.30.7-0.0-0.3-0.10.1-0.3
Fecal boli incidents, locomotor time 13.03.38.1-1.41.7-1.4-1.00.80.3-0.7-2.3-1.1-2.42.42.9-2.22.5
Change in fecal boli incidents, locomotor task0.20.10.60.4-0.80.30.0-0.40.4-0.10.3-0.10.4-0.2-0.60.2-0.4
Time >=10cm from walls, locomotor time 12.32.33.6-1.61.3-1.7-1.90.81.5-1.5-1.6-1.6-1.51.61.3-1.51.6
Bouts of movement, locomotor time 10.40.51.1-0.2-0.4-0.9-0.50.90.7-1.1-0.8-0.8-0.60.90.1-0.20.8
Total resting periods, locomotor time 10.10.20.50.1-0.4-0.5-0.20.60.3-0.7-0.4-0.4-0.20.5-0.10.10.4
Rest time, locomotor task time 11.11.24.5-0.31.4-0.30.10.1-0.70.5-1.20.3-1.51.32.1-1.71.2
Distance moved, locomotor task time 11.01.13.60.0-0.80.50.2-0.5-0.20.11.30.41.4-1.4-1.91.7-1.5
Vertical activity count, locomotor time 10.80.83.4-0.1-0.70.2-0.3-0.20.5-0.41.1-0.21.1-1.1-1.81.5-1.2
Time >=10cm from walls, locomotor time 21.61.74.8-0.40.8-0.8-1.10.10.8-0.9-1.5-0.7-1.41.72.2-2.11.7
Bouts of movement, locomotor time 20.40.41.50.20.80.30.4-1.2-0.50.7-0.20.8-0.60.21.0-0.90.3
Total resting periods, locomotor time 20.50.51.90.50.50.70.8-1.4-0.71.00.11.1-0.3-0.00.8-0.70.1
Rest time, locomotor task time 20.20.30.70.80.20.60.7-0.7-0.50.50.00.6-0.10.00.9-0.30.1
Distance moved, locomotor task time 20.30.31.0-0.3-0.9-0.4-0.50.50.4-0.80.2-0.60.3-0.2-1.00.9-0.3
Vertical activity count, locomotor time 20.40.41.4-0.5-0.5-0.5-0.80.80.9-0.80.2-0.50.5-0.4-1.20.7-0.3
Light reinforcement 10.10.10.30.2-0.50.30.30.40.10.40.2-0.20.30.0-0.60.5-0.1
Light reinforcement 20.40.51.0-0.5-0.1-0.9-0.80.60.7-1.0-0.7-0.9-0.80.80.4-0.50.8
Bone: marrow area0.40.84.60.60.5-0.0-0.3-0.30.1-0.4-0.9-0.3-1.21.12.1-1.21.2
Bone: maximum diameter0.20.30.60.4-0.6-0.0-0.00.80.0-0.2-0.5-0.5-0.50.70.8-0.80.8
Bone: maximum force0.61.13.0-0.10.1-0.6-0.40.70.2-0.4-1.3-0.5-1.31.41.7-1.71.5
Bone: maximum moment1.01.74.3-0.20.2-0.8-0.70.80.5-0.6-1.6-0.8-1.71.82.1-2.01.9
Mean time between licks in bursts2.73.89.02.1-3.02.01.9-0.6-1.11.02.11.02.8-1.8-2.12.5-1.7
Mean num. licks in bursts0.10.10.6-0.1-0.5-0.1-0.00.50.1-0.10.2-0.20.2-0.3-0.70.4-0.2
Cd content in liver0.20.21.0-0.51.0-0.1-0.1-0.10.20.4-0.30.0-0.60.10.4-1.00.1
Co content in liver1.51.76.51.10.31.51.4-2.6-1.41.61.21.60.7-1.20.00.4-1.2
Cu content in liver0.30.31.30.2-0.8-0.1-0.4-0.00.8-0.90.2-0.70.5-0.2-0.61.1-0.1
Fe content in liver0.30.40.8-0.80.3-0.9-0.70.80.6-0.8-0.6-0.8-0.70.5-0.1-0.50.5
K content in liver0.50.53.00.70.30.80.2-0.9-0.20.2-0.4-0.2-0.10.71.7-0.50.8
Mg content in liver0.60.73.91.3-0.20.7-0.0-1.10.3-0.5-0.4-0.4-0.20.82.0-0.40.8
Mn content in liver0.40.41.0-0.6-0.2-0.4-0.70.80.8-0.6-0.7-1.0-0.10.90.2-0.20.9
Na content in liver0.91.03.00.71.31.00.9-1.2-1.51.20.10.9-0.30.01.7-0.70.1
Rb content in liver0.91.14.00.8-1.10.40.3-0.5-0.3-0.41.20.41.3-1.4-1.52.0-1.3
Se content in liver1.72.13.7-0.91.3-1.2-1.41.01.1-1.3-1.7-1.6-1.71.81.9-1.41.8
Sr content in liver0.70.72.9-0.41.7-0.10.0-0.7-0.10.7-0.40.2-1.10.31.2-1.50.3
Zn content in liver0.50.52.60.90.10.60.4-1.4-0.10.2-0.30.1-0.50.61.6-0.70.6
Bone: minimum diameter0.10.20.80.9-0.70.20.2-0.6-0.3-0.1-0.10.2-0.10.20.7-0.40.2
Time in familiar zone, hab. session 11.71.63.2-0.3-0.1-1.1-1.11.11.1-1.4-1.5-1.4-1.41.81.5-1.01.8
Time in novel zone, hab. session 11.21.22.20.9-0.31.10.9-1.3-0.80.81.31.11.1-1.5-1.01.0-1.5
Total zone transitions, hab. session 11.82.67.40.4-0.2-0.8-1.0-0.11.3-1.7-1.8-1.6-1.82.32.7-1.52.3
Total locomotion distance, hab. session 11.21.73.60.8-1.1-0.7-0.80.71.0-1.9-1.3-1.6-1.21.81.8-0.81.7
Locomotion velocity, hab. session 10.60.91.81.0-1.3-0.3-0.30.40.5-1.3-0.8-1.0-0.81.31.4-0.41.2
Time in familiar zone, hab. session 20.20.21.70.30.40.20.0-1.30.2-0.0-0.10.0-0.30.30.8-0.10.3
Time in novel zone, hab. session 20.50.51.9-0.1-0.60.30.70.7-0.70.90.70.70.7-0.8-1.40.5-0.8
Total zone transitions, hab. session 20.60.73.31.8-1.01.21.0-1.1-0.80.40.20.20.10.21.10.00.2
Total locomotion distance, hab. session 20.50.72.91.7-1.70.50.5-0.2-0.2-0.6-0.2-0.5-0.10.71.00.30.7
Locomotion velocity, hab. session 20.60.82.61.5-1.60.20.20.20.0-0.9-0.5-0.9-0.41.11.3-0.01.1
Novel to familiar place preference ratio0.70.71.60.8-1.30.80.8-0.1-0.70.60.90.41.1-0.8-1.21.0-0.7
Novelty place preference0.70.71.40.6-1.10.70.90.1-0.80.70.80.41.1-0.8-1.20.9-0.7
Time in novel zone, NPP test0.80.91.70.7-1.20.80.9-0.1-0.70.71.00.51.2-1.0-1.31.2-0.9
Total zone transitions, NPP test0.40.52.40.5-0.20.10.2-0.4-0.1-0.2-0.8-0.4-0.81.11.6-0.81.1
Total locomotion distance, NPP test0.30.51.60.7-1.3-0.10.00.60.1-0.7-0.6-0.9-0.41.00.70.11.0
Locomotion velocity, NPP test0.40.61.60.4-0.8-0.2-0.10.60.0-0.6-0.9-0.9-0.81.21.1-0.61.3
Intraocular pressure1.52.18.20.7-2.9-0.4-0.71.31.7-1.90.6-1.21.3-0.4-2.11.8-0.4
Delta distance traveled before/after self-admin0.30.30.9-0.40.20.20.5-0.0-0.70.60.50.30.5-0.6-0.90.9-0.6
Delta ambulatory time before/after self-admin0.20.20.5-0.40.40.00.3-0.3-0.60.40.30.20.2-0.5-0.60.7-0.5
Parametrial fat weight1.01.93.41.6-0.71.81.7-1.5-1.41.41.51.61.2-1.3-0.31.0-1.5
Pavlov. Cond. lever latency2.93.77.61.9-2.31.71.5-0.8-0.90.82.31.32.5-2.2-2.42.8-2.2
Pavlov. Cond. magazine entry latency0.20.20.5-0.2-0.1-0.5-0.40.70.3-0.7-0.5-0.7-0.30.60.3-0.10.6
Pavlov. Cond. change in total contacts4.24.57.9-2.62.1-2.1-1.52.01.1-0.5-2.5-1.5-2.62.51.7-2.82.5
Pavlov. Cond. index score1.11.42.5-1.21.2-1.1-0.80.90.5-0.6-1.4-0.9-1.51.41.3-1.61.4
Pavlov. Cond. latency score1.31.63.3-1.31.5-1.2-0.90.90.5-0.5-1.5-0.9-1.61.51.4-1.81.5
Pavlov. Cond. lever contacts3.23.87.5-2.12.7-1.7-1.51.00.9-0.7-2.2-1.3-2.42.12.3-2.72.1
Pavlov. Cond. magazine entry number0.91.11.80.8-0.51.10.9-0.9-0.81.11.31.21.2-1.3-1.01.0-1.3
Pavlov. Cond. intertrial magazine entries0.30.31.9-1.41.0-0.6-0.30.6-0.10.4-0.10.00.1-0.2-0.7-0.4-0.3
Pavlov. Cond. lever-magazine prob. diff.1.41.72.8-1.41.3-1.3-1.01.00.7-0.7-1.5-1.1-1.61.51.2-1.71.5
Pavlov. Cond. response bias1.51.83.0-1.10.7-1.3-1.21.11.1-1.2-1.6-1.4-1.51.71.3-1.41.7
Pavlov. Cond. lever latency4.35.88.62.9-2.22.92.9-2.2-2.52.32.62.42.4-2.3-1.31.8-2.3
Pavlov. Cond. magazine entry latency2.42.84.0-1.41.5-1.8-2.01.12.0-1.9-1.8-1.8-1.91.71.5-1.21.7
Pavlov. Cond. change in total contacts6.18.311.8-3.32.5-3.3-3.42.73.1-2.8-3.1-3.1-2.82.91.8-2.32.9
Pavlov. Cond. index score5.67.210.6-2.92.3-3.2-3.32.43.0-2.9-2.8-2.9-2.72.61.7-1.92.6
Pavlov. Cond. latency score5.97.310.6-3.12.4-3.2-3.32.62.9-2.8-2.8-2.9-2.72.61.6-1.92.6
Pavlov. Cond. lever contacts6.08.212.1-3.32.5-3.5-3.52.53.1-2.9-3.1-2.9-2.92.81.7-2.32.8
Pavlov. Cond. magazine entry number3.64.46.11.8-2.12.22.4-1.3-2.42.22.22.12.5-2.1-2.11.7-2.1
Pavlov. Cond. intertrial magazine entries2.02.67.20.5-0.71.72.2-0.1-2.62.71.51.91.7-1.4-1.40.4-1.4
Pavlov. Cond. lever-magazine prob. diff.5.77.210.4-2.92.5-3.2-3.22.42.9-2.8-2.8-2.9-2.72.61.7-2.02.6
Pavlov. Cond. response bias4.76.39.3-2.62.1-3.0-3.02.02.8-2.7-2.7-2.6-2.62.51.8-2.12.5
Time in closed arm before self-admin0.20.21.1-0.31.00.00.0-0.10.10.4-0.30.3-0.60.20.6-0.70.2
Time in closed arm after self-admin0.60.62.50.30.20.81.0-0.6-1.01.60.71.10.2-0.7-0.5-0.2-0.7
Time in open arm before self-admin0.30.42.1-0.00.8-0.10.2-1.4-0.90.60.00.5-0.4-0.30.4-0.8-0.2
Time in open arm after self-admin0.30.30.5-0.2-0.4-0.5-0.50.60.4-0.7-0.6-0.7-0.20.70.5-0.50.7
Bone: periosteal estimation0.51.12.70.2-0.2-0.5-0.60.70.6-0.8-1.2-0.9-1.11.51.7-1.41.5
Bone: periosteal perimeter0.20.31.70.5-1.3-0.1-0.10.90.5-0.7-0.2-0.7-0.00.4-0.10.10.4
Bone: post-yield work0.20.31.00.4-0.30.00.4-0.8-0.70.3-0.20.6-0.40.20.6-1.00.3
Progressive ratio test 1 active lever presses0.30.31.40.6-1.20.20.20.20.1-0.00.60.30.9-0.4-0.90.5-0.5
Progressive ratio test 1 breakpoint0.40.42.00.8-1.40.30.20.10.1-0.20.60.30.8-0.5-0.90.6-0.5
Progressive ratio test 1 inactive lever presses2.62.97.7-1.4-0.1-1.8-2.12.82.5-2.2-1.4-2.1-0.91.50.2-0.51.5
Progressive ratio test 2 active lever presses0.50.61.4-1.10.8-1.2-0.80.80.3-0.6-0.6-0.5-1.00.70.4-0.40.5
Progressive ratio test 2 breakpoint0.60.71.4-1.21.0-1.2-0.90.70.5-0.6-0.8-0.6-1.11.00.6-0.70.7
Progressive ratio test 2 inactive lever presses0.60.71.8-1.31.4-1.0-0.91.10.5-0.6-0.7-0.5-0.70.60.6-0.20.5
Incentive Sensitization - Responses1.21.22.7-1.71.5-1.5-1.01.10.5-0.7-1.0-0.9-1.51.00.7-0.70.7
Incentive Sensitization - Breakpoint1.11.22.7-1.61.6-1.5-1.00.90.4-0.6-1.0-0.8-1.61.00.7-0.70.7
Sum of active levers in priming session hrs 5-61.31.34.40.0-1.1-0.8-1.21.31.8-2.10.0-1.60.5-0.0-0.91.3-0.0
Progressive ratio0.10.21.00.10.30.40.5-1.0-0.30.60.10.4-0.1-0.10.40.3-0.0
Food seeking constrained by brief footshock0.50.72.5-0.4-1.1-0.7-0.61.21.4-0.60.1-0.60.3-0.2-1.60.4-0.2
Seeking ratio, punishment vs. effort0.30.41.5-0.0-0.9-0.5-0.51.20.7-0.70.2-0.40.4-0.2-1.20.0-0.3
Retroperitoneal fat weight0.51.610.32.1-3.20.70.5-0.00.2-1.10.8-0.31.4-0.6-1.01.4-0.4
Reaction time number correct0.60.92.8-1.70.5-1.4-1.31.11.1-1.0-0.5-1.0-0.40.1-1.00.10.2
Reaction time mean minus median0.71.02.7-1.3-0.1-1.1-1.21.31.6-1.1-0.8-1.2-0.30.6-0.40.00.7
Reaction time mean minus median AUC0.81.13.3-1.6-0.1-1.2-1.21.81.5-1.0-0.5-1.0-0.10.3-1.20.40.4
Reaction time num false alarms0.81.13.00.41.21.01.1-1.6-1.61.70.31.3-0.1-0.40.9-0.5-0.4
Reaction time num false alarms AUC1.72.35.71.20.51.81.9-2.4-2.22.41.02.00.6-1.10.4-0.1-1.0
Reaction time trials correct on left0.60.92.8-1.70.5-1.4-1.31.11.1-1.0-0.5-1.0-0.40.1-1.00.10.2
Reaction time trials on left0.60.92.6-1.60.4-1.4-1.21.11.1-1.0-0.4-1.1-0.30.1-1.10.20.2
Reaction time mean0.10.10.30.5-0.50.1-0.1-0.20.4-0.60.1-0.1-0.0-0.10.20.4-0.0
Reaction time mean AUC0.10.20.70.6-0.90.30.1-0.10.3-0.40.4-0.00.3-0.3-0.30.8-0.3
Median of all reaction times0.10.21.11.0-0.50.30.2-0.6-0.0-0.50.20.1-0.1-0.10.50.4-0.1
Reaction time omissions0.81.05.20.7-2.30.2-0.00.60.7-1.00.4-0.91.1-0.2-1.21.8-0.0
Reaction time false alarm rate1.82.56.11.50.52.02.1-2.3-2.32.50.82.10.4-0.81.0-0.5-0.7
Reaction time premature initiation rate0.60.83.2-0.9-0.6-0.5-0.61.00.7-0.70.3-0.71.2-0.4-1.81.3-0.4
Reaction time premature initiations1.21.65.9-1.6-0.5-1.1-1.21.71.3-1.30.1-1.21.1-0.3-2.41.6-0.3
Std. dev. reaction times0.20.20.8-0.1-0.70.2-0.00.30.4-0.20.3-0.10.6-0.3-0.80.9-0.3
Reaction time trials completed0.60.92.6-1.60.4-1.4-1.21.11.1-1.0-0.4-1.1-0.30.1-1.10.20.2
Reaction time trials AUC0.60.82.8-1.70.6-1.4-1.21.01.0-0.8-0.4-0.9-0.30.0-1.00.10.1
Run reversals in cocaine runway, females0.10.10.2-0.30.0-0.30.10.5-0.40.1-0.0-0.1-0.1-0.1-0.3-0.0-0.1
Run reversals in cocaine runway, males4.84.713.01.50.42.32.3-3.6-2.73.01.93.11.3-2.1-0.3-0.2-2.0
Latency to leave start box in cocaine runway0.20.20.5-0.70.2-0.5-0.40.70.3-0.3-0.1-0.3-0.1-0.1-0.60.4-0.0
Latency to leave start box in cocaine runway, F0.30.30.9-0.80.1-0.7-0.30.90.2-0.2-0.6-0.5-0.60.5-0.0-0.30.7
Latency to leave start box in cocaine runway, M0.10.10.7-0.00.4-0.1-0.2-0.10.2-0.40.20.0-0.0-0.4-0.10.8-0.4
Std. dev. time between licks in bursts0.80.93.21.8-1.51.11.0-0.8-0.80.10.80.61.0-0.7-0.11.2-0.6
Total sessions with >9 infusions0.70.82.01.4-1.11.01.2-0.1-1.00.80.81.00.7-0.7-0.30.6-0.6
Short access day 1 total inactive lever presses0.40.41.6-0.81.3-0.7-0.90.40.8-0.5-0.5-0.1-0.70.30.5-0.60.3
Short access day 10 total inactive lever presses0.30.42.3-0.60.0-0.3-0.51.50.8-0.30.1-0.00.4-0.1-0.60.8-0.2
Short access day 1 total infusions0.60.61.80.90.50.80.8-1.0-1.01.00.71.30.1-0.80.2-0.1-0.8
Short access day 10 total infusions0.00.10.2-0.10.2-0.3-0.30.00.5-0.2-0.10.1-0.10.10.1-0.4-0.0
Short access total infusions0.10.10.50.30.40.00.1-0.1-0.30.40.20.7-0.3-0.30.2-0.6-0.3
Short access day 1 locomotion0.40.51.31.2-1.00.90.9-0.4-0.60.60.60.60.6-0.5-0.20.4-0.3
Short access day 10 total locomotion0.60.72.0-0.10.2-0.9-1.01.11.0-1.4-0.7-0.7-0.60.70.90.00.6
Short access total locomotion0.50.51.20.3-0.3-0.6-0.60.90.9-1.1-0.7-0.4-0.80.81.0-0.50.8
One hour access (0.3 mA shock)0.60.61.9-0.70.4-1.0-1.40.71.3-1.2-0.6-0.9-0.30.50.2-0.40.5
Compulsive drug intake0.20.20.80.4-0.3-0.0-0.4-0.70.7-0.40.0-0.3-0.1-0.30.1-0.90.0
One hour access (shock baseline)0.20.21.2-0.61.1-0.3-0.4-0.0-0.1-0.2-0.40.2-0.30.30.70.00.2
Social response proportion0.50.51.80.4-1.3-0.3-0.60.50.8-1.3-0.1-1.00.50.2-0.50.50.2
Social responses0.30.41.2-0.0-1.1-0.2-0.51.10.8-0.7-0.5-1.00.30.7-0.10.10.7
Social time0.20.20.70.6-0.80.80.6-0.1-0.20.30.40.20.8-0.1-0.20.6-0.1
Soleus weight1.13.26.0-1.21.1-1.5-1.31.31.0-0.9-2.2-1.4-2.32.32.2-2.52.3
Bone: stiffness0.20.41.50.2-0.00.50.9-0.2-1.21.20.10.9-0.0-0.10.2-0.6-0.0
Tibialis anterior weight0.72.39.30.8-0.3-0.1-0.30.20.5-0.4-1.7-0.7-1.82.33.1-2.22.3
Time to tail flick, vehicle, before self-admin1.51.62.6-1.61.6-1.3-1.10.70.6-0.5-1.5-0.7-1.51.61.3-1.31.5
Time to tail flick, vehicle, after self-admin1.51.65.3-1.0-1.0-1.3-1.42.31.8-1.6-0.7-1.70.10.9-0.90.30.8
Time to tail flick, test, before self-admin0.10.10.3-0.40.5-0.3-0.00.5-0.10.1-0.2-0.0-0.50.10.10.10.1
Time to tail flick, test, after self-admin0.00.00.1-0.1-0.0-0.2-0.2-0.10.1-0.2-0.20.0-0.10.20.2-0.30.2
Delta time to tail flick, vehicle, before/after SA1.71.74.80.3-2.2-0.5-0.91.81.7-1.70.3-1.41.2-0.3-2.01.3-0.2
Delta time to tail flick, test, before/after SA0.30.30.9-0.3-0.2-0.4-0.80.00.9-0.7-0.6-0.4-0.00.60.2-0.60.6
Tibia length0.10.41.20.8-0.20.2-0.3-0.60.9-0.8-0.3-0.7-0.30.51.1-0.10.5
Ambulatory time before self-admin1.21.23.40.2-1.4-0.5-0.91.81.6-1.4-0.8-1.6-0.11.20.10.01.2
Ambulatory time after self-admin0.40.51.80.1-1.0-0.1-0.31.40.8-0.6-0.1-1.20.50.3-0.60.80.4
Bone: tissue strength0.60.62.11.00.00.80.8-0.7-0.90.9-0.10.8-0.40.41.5-0.90.4
Total heroin consumption0.40.41.3-0.2-0.2-0.6-0.91.01.2-1.1-0.2-0.9-0.00.2-0.10.30.2
Bone: trabecular number4.26.520.3-4.53.1-3.2-2.93.02.3-1.5-2.4-2.4-2.01.90.0-2.21.8
Bone: trabecular spacing2.83.78.93.0-1.42.62.5-2.6-2.31.81.72.01.2-1.30.41.0-1.3
Bone: trabecular thickness6.07.29.6-2.82.1-3.0-3.12.72.8-2.5-3.0-2.7-2.62.81.9-2.42.8
Bone: trabecular tissue density0.60.85.21.2-2.30.70.80.7-0.40.30.60.10.9-0.3-0.80.5-0.3
Water consumed over 24 hours0.30.42.5-1.11.6-0.2-0.4-0.40.10.30.20.30.1-0.7-0.50.1-0.6
Number of responses in last shaping day0.20.20.60.40.20.70.60.4-0.60.60.10.50.3-0.10.30.8-0.0