Hub : Genes

Apoc4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Apoc4 0.59 0.14 0.0e+00 0.49 0.49 0.49 0.49 2.9e-61 7.5e-62 1.3e-62 2.6e-62
2 Liver mRNA stability Apoc4 0.04 0.03 9.9e-04 0.03 0.02 0.02 0.02 4.9e-04 1.1e-03 1.6e-03 2.4e-03
3 BLA gene expression Apoc4 0.07 0.06 2.4e-03 0.03 0.04 0.04 0.03 1.0e-02 5.2e-03 4.2e-03 8.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.00.10.10.30.2-0.3
Area under the delay curve1.61.82.3-1.51.41.2
BMI with tail0.82.73.51.7-1.4-1.9
BMI without tail0.61.72.01.4-1.4-1.1
Body weight1.46.07.02.4-2.2-2.7
Weight adjusted by age0.00.00.0-0.0-0.1-0.2
Bone surface0.40.81.20.9-0.5-1.1
Bone volume0.40.71.20.8-0.4-1.1
Breakpoint value in progressive ratio session1.92.22.7-1.61.61.3
Number of licking bursts2.03.34.41.8-2.1-1.5
Context. condit. distance diff. score0.30.40.80.5-0.3-0.9
Locomotion velocity, session 10.10.10.1-0.20.3-0.3
Locomotion distance, session 10.10.10.20.4-0.1-0.3
Locomotion velocity, session 20.81.01.61.0-1.3-0.6
Locomotion distance, session 20.20.30.60.7-0.5-0.1
Locomotion velocity, session 30.10.10.30.4-0.5-0.1
Locomotion distance, session 31.31.42.3-1.10.91.5
Stereotopy head waving bouts, day 30.50.61.30.6-1.10.2
Stereotopy head waving duration, day 30.80.91.41.0-1.2-0.6
Locomotion velocity, session 70.10.10.2-0.20.40.4
Locomotion distance, session 70.10.20.30.3-0.2-0.6
Stereotopy head waving bouts, day 70.70.81.01.0-1.0-0.7
Stereotopy head waving duration, day 70.70.80.90.9-1.0-0.8
Locomotion velocity, session 80.10.10.2-0.30.00.4
Locomotion distance, session 80.10.10.10.30.0-0.3
Degree of sensitization distance1.41.42.51.0-0.8-1.6
Degree of sensitization stereotypy0.90.91.11.0-1.0-0.9
Conditioned locomotion0.70.82.2-0.30.21.5
Cocaine response after cond. corrected0.50.60.91.0-0.8-0.5
Cocaine response after cond. not corrected1.31.52.21.5-1.3-0.9
Cocaine response before conditioning1.21.41.91.2-1.4-0.8
Saline control response1.82.32.81.6-1.7-1.3
Bone: connectivity density0.00.10.10.10.40.1
Bone: cortical apparent density0.10.10.2-0.20.40.2
Bone: cortical area1.72.62.91.5-1.6-1.7
Bone: cortical porosity1.41.53.6-0.90.31.9
Bone: cortical porosity0.80.92.4-0.5-0.11.5
Bone: cortical thickness0.50.81.01.0-1.0-0.7
Bone: cortical thickness1.21.41.61.3-1.2-1.0
Bone: cortical tissue density0.10.20.3-0.40.50.3
Condit. Reinf. active minus inactive responses0.60.60.80.9-0.6-0.9
Condit. Reinf. active-inactive response ratio0.60.71.00.9-0.4-1.0
Condit. Reinf. active responses0.30.40.60.8-0.4-0.7
Condit. Reinf. inactive responses0.00.00.10.00.20.1
Incentive salience index mean0.20.20.40.6-0.4-0.2
Condit. Reinf. lever presses0.00.10.20.2-0.10.4
Condit. Reinf. active minus inactive responses0.20.20.30.4-0.3-0.5
Condit. Reinf. active-inactive response ratio0.50.50.70.8-0.7-0.7
Condit. Reinf. active responses0.10.10.1-0.30.30.3
Condit. Reinf. inactive responses0.81.11.2-1.10.91.1
Condit. Reinf. lever presses0.40.61.20.6-0.5-1.1
Condit. Reinf. lever reinforcers received0.10.20.2-0.40.30.5
Conditioned reinforcement - actives1.01.82.01.4-1.4-1.1
Conditioned reinforcement - inactives0.30.40.60.5-0.8-0.5
Conditioned locomotion2.22.83.01.7-1.7-1.6
Patch foraging indifference point 0 sec0.30.50.70.8-0.8-0.3
Patch foraging indifference point AUC2.23.14.61.9-2.2-1.1
Delay disc. indifference point, 0s delay2.02.23.1-1.41.21.8
Delay disc. indifference point, 16s delay1.01.11.3-1.11.10.9
Delay disc. indifference point, 2s delay2.83.14.5-2.11.91.1
Delay disc. indifference point, 24s delay0.70.81.90.6-0.2-1.4
Delay disc. indifference point, 4s delay0.00.00.1-0.2-0.00.3
Delay disc. indifference point, 8s delay1.61.92.2-1.51.41.3
Indifference point function ln k0.61.01.7-1.01.30.5
Indifference point function log k0.61.01.7-1.01.30.5
Patch foraging total patch changes 0 sec0.50.91.21.1-1.0-0.8
Patch foraging total patch changes 12 sec0.91.11.91.1-1.4-0.3
Patch foraging total patch changes 18 sec1.92.93.41.8-1.6-1.6
Patch foraging total patch changes 24 sec0.20.30.50.7-0.6-0.1
Patch foraging total patch changes 6 sec1.62.43.71.8-1.9-0.7
Patch foraging time to switch 0 sec2.24.46.0-2.42.21.5
Patch foraging water rate 0 sec2.24.66.32.5-2.4-1.3
Patch foraging water rate 12 sec0.20.30.50.7-0.4-0.6
Patch foraging water rate 18 sec0.10.20.30.5-0.3-0.5
Patch foraging water rate 24 sec0.50.71.01.0-0.8-0.8
Patch foraging water rate 6 sec1.01.52.21.3-0.9-1.5
Seeking ratio, delayed vs. immediate footshock2.63.24.7-1.51.62.2
Distance traveled before self-admin0.10.10.20.3-0.3-0.5
Distance traveled after self-admin0.20.30.4-0.50.40.6
Extensor digitorum longus weight2.08.09.82.7-2.6-3.1
Bone: elastic displacement1.31.51.8-1.21.21.3
Bone: elastic work0.10.10.30.0-0.10.5
Bone: endosteal estimation0.00.10.1-0.10.2-0.4
Bone: endosteal perimeter0.10.20.50.1-0.1-0.7
Epididymis fat weight0.20.81.0-1.00.90.8
Delta time in closed arm before/after self-admin0.10.00.1-0.10.4-0.0
Delta time in open arm before/after self-admin0.00.00.1-0.30.10.1
Diff in mean of infusions in LGA sessions1.11.31.7-1.31.30.8
Delay discount exponential model param1.11.21.61.3-1.1-0.9
Extinction: sum of active levers before priming0.40.51.3-0.30.21.1
Active lever presses in extinction session 60.10.10.20.3-0.2-0.4
Bone: final force0.30.50.60.7-0.8-0.7
Bone: final moment0.40.70.90.9-0.9-0.7
Food consumed during 24 hour testing period4.35.97.6-2.42.82.1
Glucose0.30.40.6-0.80.50.7
Heart weight2.03.13.71.8-1.9-1.5
Delay discount hyperbolic model param1.01.11.51.2-1.0-0.8
Intermittent access intake day 1-15 change0.10.30.40.5-0.4-0.7
Intermittent access intake escalation0.20.40.50.6-0.5-0.7
Intermittent access intake escalation 20.00.10.10.1-0.10.4
Intermitt. access day 1 inactive lever presses0.00.00.0-0.0-0.1-0.1
Intermitt. access day 15 inactive lever presses0.10.30.80.0-0.0-0.9
Intermitt. access escalation Index0.30.40.6-0.50.60.8
Intermittent access day 1 total infusions1.11.82.41.3-1.5-1.1
Intermittent access day 15 total infusions0.81.21.41.0-1.1-1.2
Intermittent access terminal intake (last 3 days)1.21.51.61.2-1.2-1.3
Intermittent access total infusions2.52.93.11.7-1.7-1.7
Intermittent access day 1 locomotion0.20.20.40.5-0.6-0.2
Intermittent access day 15 total locomotion0.10.20.30.4-0.5-0.3
Intermittent access total locomotion1.41.62.01.3-1.4-1.1
Intermittent access standard deviation0.10.10.2-0.50.40.2
Left kidney weight5.224.028.35.3-5.0-4.3
Right kidney weight4.821.925.65.1-4.8-4.1
Cocaine induced anxiety0.10.20.3-0.50.50.2
Post-drug Anxiety0.00.00.1-0.30.1-0.1
Baseline Anxiety0.00.00.0-0.1-0.10.0
Tail length0.31.11.31.0-1.1-0.9
Length with tail0.41.62.01.2-1.1-1.4
Length without tail0.82.74.91.5-1.0-2.2
Times rat made contact with spout0.00.00.10.30.2-0.2
Lifetime Intake2.22.72.91.6-1.7-1.6
Liver weight, left1.42.23.61.6-1.9-0.8
Liver weight, right1.52.63.21.6-1.4-1.8
Locomotor activity1.52.34.01.5-2.0-0.8
Locomotor testing distance0.71.32.41.2-1.5-0.4
Locomotor testing rearing3.77.48.92.9-3.0-2.2
Locomotion in novel chamber0.10.10.2-0.40.30.4
Locomotion in novel chamber post-restriction1.11.82.3-1.21.31.5
Fecal boli incidents, locomotor time 10.00.00.10.1-0.2-0.1
Change in fecal boli incidents, locomotor task0.70.61.0-1.00.90.4
Time >=10cm from walls, locomotor time 10.00.00.00.20.1-0.1
Bouts of movement, locomotor time 11.82.02.8-1.51.70.9
Total resting periods, locomotor time 12.42.63.6-1.81.91.1
Rest time, locomotor task time 10.10.10.2-0.40.5-0.0
Distance moved, locomotor task time 10.20.30.60.5-0.80.1
Vertical activity count, locomotor time 10.10.31.0-0.20.01.0
Time >=10cm from walls, locomotor time 20.20.30.7-0.50.20.9
Bouts of movement, locomotor time 23.15.07.2-2.42.71.4
Total resting periods, locomotor time 22.54.46.5-2.22.51.4
Rest time, locomotor task time 20.10.10.1-0.10.30.3
Distance moved, locomotor task time 20.50.61.00.8-1.0-0.4
Vertical activity count, locomotor time 20.10.10.2-0.40.20.4
Light reinforcement 10.10.20.30.5-0.3-0.5
Light reinforcement 20.10.10.10.3-0.3-0.3
Bone: marrow area0.00.10.1-0.00.1-0.4
Bone: maximum diameter2.75.05.72.2-2.1-2.4
Bone: maximum force0.20.30.40.5-0.5-0.6
Bone: maximum moment0.20.40.40.6-0.7-0.6
Mean time between licks in bursts0.10.30.9-0.30.30.9
Mean num. licks in bursts2.03.14.7-1.62.21.5
Cd content in liver0.10.10.30.20.2-0.6
Co content in liver1.51.72.0-1.31.21.4
Cu content in liver0.40.40.70.5-0.5-0.9
Fe content in liver5.16.27.52.2-2.5-2.7
K content in liver0.10.10.10.1-0.30.3
Mg content in liver0.30.30.60.4-0.70.1
Mn content in liver0.60.71.00.8-1.00.7
Na content in liver0.10.10.30.1-0.5-0.4
Rb content in liver0.30.40.70.6-0.2-0.9
Se content in liver2.32.74.71.6-2.2-0.8
Sr content in liver0.10.10.2-0.1-0.30.4
Zn content in liver0.70.81.00.9-0.8-1.0
Bone: minimum diameter0.30.50.90.5-0.6-1.0
Time in familiar zone, hab. session 10.20.20.20.4-0.5-0.4
Time in novel zone, hab. session 10.60.60.60.7-0.8-0.8
Total zone transitions, hab. session 10.30.40.60.7-0.4-0.8
Total locomotion distance, hab. session 10.40.50.6-0.80.70.6
Locomotion velocity, hab. session 11.11.61.8-1.41.31.1
Time in familiar zone, hab. session 20.30.30.40.4-0.5-0.6
Time in novel zone, hab. session 20.00.00.1-0.10.2-0.2
Total zone transitions, hab. session 20.30.40.70.6-0.8-0.1
Total locomotion distance, hab. session 20.71.01.2-1.00.81.1
Locomotion velocity, hab. session 20.50.71.1-0.80.71.0
Novel to familiar place preference ratio1.31.41.91.3-0.7-1.4
Novelty place preference1.11.21.61.2-0.7-1.3
Time in novel zone, NPP test1.31.41.81.3-0.8-1.3
Total zone transitions, NPP test0.10.10.20.4-0.4-0.3
Total locomotion distance, NPP test0.20.20.30.5-0.4-0.6
Locomotion velocity, NPP test0.10.20.20.4-0.3-0.4
Intraocular pressure0.20.30.80.20.0-0.9
Delta distance traveled before/after self-admin2.02.12.2-1.51.41.5
Delta ambulatory time before/after self-admin0.60.81.3-0.80.71.1
Parametrial fat weight0.10.10.20.3-0.50.4
Pavlov. Cond. lever latency0.40.50.7-0.90.70.4
Pavlov. Cond. magazine entry latency0.20.30.50.5-0.2-0.7
Pavlov. Cond. change in total contacts0.60.60.7-0.60.80.9
Pavlov. Cond. index score0.20.20.40.6-0.5-0.3
Pavlov. Cond. latency score0.00.00.10.3-0.20.0
Pavlov. Cond. lever contacts0.20.30.50.7-0.5-0.4
Pavlov. Cond. magazine entry number0.10.10.2-0.30.00.4
Pavlov. Cond. intertrial magazine entries0.10.10.10.3-0.30.4
Pavlov. Cond. lever-magazine prob. diff.0.20.20.40.6-0.5-0.1
Pavlov. Cond. response bias1.01.31.51.2-0.9-1.2
Pavlov. Cond. lever latency0.00.00.0-0.20.20.1
Pavlov. Cond. magazine entry latency0.70.81.90.8-0.1-1.4
Pavlov. Cond. change in total contacts0.10.10.2-0.10.5-0.3
Pavlov. Cond. index score0.10.20.50.30.1-0.7
Pavlov. Cond. latency score0.10.10.30.10.3-0.5
Pavlov. Cond. lever contacts0.10.20.30.5-0.3-0.5
Pavlov. Cond. magazine entry number0.30.40.8-0.0-0.60.9
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.3-0.00.4
Pavlov. Cond. lever-magazine prob. diff.0.20.30.70.5-0.0-0.8
Pavlov. Cond. response bias0.10.10.20.30.0-0.5
Time in closed arm before self-admin1.01.31.61.1-1.0-1.3
Time in closed arm after self-admin0.40.40.8-0.70.90.1
Time in open arm before self-admin1.41.52.4-1.10.91.5
Time in open arm after self-admin0.70.81.8-0.70.31.3
Bone: periosteal estimation0.40.91.50.8-0.8-1.2
Bone: periosteal perimeter0.50.91.50.7-0.7-1.2
Bone: post-yield work0.40.61.1-0.91.00.0
Progressive ratio test 1 active lever presses1.62.03.21.5-1.8-0.7
Progressive ratio test 1 breakpoint1.41.72.81.4-1.7-0.6
Progressive ratio test 1 inactive lever presses1.31.92.11.2-1.4-1.5
Progressive ratio test 2 active lever presses2.12.52.81.5-1.7-1.6
Progressive ratio test 2 breakpoint2.42.83.11.6-1.7-1.7
Progressive ratio test 2 inactive lever presses0.20.30.50.2-0.5-0.7
Incentive Sensitization - Responses1.82.54.11.3-1.3-2.0
Incentive Sensitization - Breakpoint1.82.33.81.2-1.2-2.0
Sum of active levers in priming session hrs 5-60.90.81.9-0.60.51.4
Progressive ratio0.81.32.0-1.31.40.5
Food seeking constrained by brief footshock5.56.77.3-2.52.52.7
Seeking ratio, punishment vs. effort0.81.22.3-0.80.81.5
Retroperitoneal fat weight0.10.30.70.4-0.4-0.8
Reaction time number correct3.16.07.32.7-2.7-1.9
Reaction time mean minus median0.00.10.1-0.00.3-0.3
Reaction time mean minus median AUC0.30.71.30.8-0.4-1.1
Reaction time num false alarms4.66.57.02.6-2.4-2.7
Reaction time num false alarms AUC3.35.15.52.3-2.2-2.2
Reaction time trials correct on left3.16.07.32.7-2.7-1.9
Reaction time trials on left3.26.07.32.7-2.7-1.9
Reaction time mean0.61.01.8-0.91.30.5
Reaction time mean AUC0.50.71.4-0.81.20.4
Median of all reaction times0.91.32.2-1.11.50.7
Reaction time omissions0.10.10.20.30.0-0.4
Reaction time false alarm rate0.30.40.70.5-0.4-0.8
Reaction time premature initiation rate0.60.81.3-0.60.81.1
Reaction time premature initiations0.20.30.50.7-0.60.1
Std. dev. reaction times0.10.10.3-0.30.50.1
Reaction time trials completed3.26.07.32.7-2.7-1.9
Reaction time trials AUC3.97.48.83.0-3.0-2.1
Run reversals in cocaine runway, females0.10.10.3-0.40.50.0
Run reversals in cocaine runway, males0.40.40.60.8-0.7-0.5
Latency to leave start box in cocaine runway0.40.51.00.6-0.1-1.0
Latency to leave start box in cocaine runway, F0.60.71.01.0-0.8-0.7
Latency to leave start box in cocaine runway, M0.40.30.90.00.4-0.9
Std. dev. time between licks in bursts0.00.00.00.10.00.1
Total sessions with >9 infusions2.83.44.62.0-2.1-1.3
Short access day 1 total inactive lever presses0.60.81.20.8-0.8-1.1
Short access day 10 total inactive lever presses0.40.91.3-1.11.10.5
Short access day 1 total infusions1.41.82.51.4-1.6-1.0
Short access day 10 total infusions2.83.64.62.0-2.1-1.5
Short access total infusions1.62.12.81.5-1.7-1.2
Short access day 1 locomotion2.43.03.81.9-2.0-1.2
Short access day 10 total locomotion0.00.00.00.2-0.00.1
Short access total locomotion0.40.50.80.8-0.90.1
One hour access (0.3 mA shock)0.20.20.60.2-0.2-0.8
Compulsive drug intake0.20.20.20.5-0.5-0.4
One hour access (shock baseline)1.01.51.91.2-1.1-1.4
Social response proportion1.61.92.51.5-1.0-1.6
Social responses1.01.31.41.2-1.0-1.2
Social time2.63.64.6-2.02.11.5
Soleus weight0.51.43.20.9-0.5-1.8
Bone: stiffness1.01.72.41.1-1.2-1.5
Tibialis anterior weight3.612.313.33.6-3.3-3.7
Time to tail flick, vehicle, before self-admin1.81.83.11.5-1.8-0.3
Time to tail flick, vehicle, after self-admin0.40.51.30.3-0.2-1.1
Time to tail flick, test, before self-admin1.31.32.8-0.80.71.7
Time to tail flick, test, after self-admin0.20.20.3-0.50.40.3
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.20.3-0.6
Delta time to tail flick, test, before/after SA1.51.52.80.9-1.0-1.7
Tibia length0.30.70.90.9-0.8-0.8
Ambulatory time before self-admin0.00.00.10.00.0-0.3
Ambulatory time after self-admin0.50.60.6-0.80.70.8
Bone: tissue strength0.90.91.2-0.90.91.1
Total heroin consumption0.00.00.10.00.10.3
Bone: trabecular number0.00.10.2-0.00.4-0.0
Bone: trabecular spacing0.00.00.10.1-0.3-0.1
Bone: trabecular thickness1.51.82.11.5-1.3-1.3
Bone: trabecular tissue density0.50.70.90.8-0.8-1.0
Water consumed over 24 hours0.10.20.2-0.10.50.5
Number of responses in last shaping day2.93.23.51.9-1.8-1.7