Hub : Genes

Apip

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain isoform ratio NM_001106492.2 0.03 0.03 1.5e-03 0.02 0 0.02 -0 5.8e-03 1.8e-01 1.0e-02 3.9e-01
2 BLA isoform ratio NM_001106492.2 0.12 0.11 1.4e-05 0.09 0.09 0.06 0.09 1.8e-05 1.9e-05 2.5e-04 2.7e-05
3 PL gene expression Apip 0.77 0.04 0.0e+00 0.45 0.44 0.44 0.44 1.9e-54 8.3e-54 7.3e-54 1.2e-53
4 pVTA gene expression Apip 0.24 0.24 6.8e-07 0.15 0.14 0.11 0.13 5.0e-07 1.6e-06 1.9e-05 3.2e-06
5 IL mRNA stability Apip 0.55 0.2 8.5e-14 0.34 0.42 0.41 0.42 4.8e-09 2.7e-11 7.4e-11 3.9e-11
6 Adipose gene expression Apip 0.07 0.06 4.1e-07 0.06 0.05 0.05 0.05 9.9e-07 3.2e-06 2.5e-06 1.6e-06
7 IL gene expression Apip 0.44 0.22 3.4e-10 0.37 0.35 0.36 0.34 9.4e-10 2.4e-09 1.1e-09 4.0e-09
8 IL intron excision ratio chr3_89432141_89449197 0.15 0.13 1.3e-03 0.1 0.09 0.04 0.08 1.7e-03 3.1e-03 3.8e-02 5.2e-03
9 LHb gene expression Apip 0.19 0.16 7.1e-04 0.1 0.1 0.1 0.1 1.8e-03 2.2e-03 3.0e-03 2.6e-03
10 NAcc mRNA stability Apip 0.27 0.15 0.0e+00 0.3 0.3 0.3 0.3 3.7e-35 1.4e-35 1.0e-35 9.5e-36
11 PL isoform ratio NM_001106492.2 0.03 0.03 1.7e-03 0.01 0.02 0.01 0.01 8.1e-03 2.3e-03 3.6e-02 8.7e-03
12 NAcc isoform ratio NM_001106492.2 0.03 0.03 1.1e-03 0.02 0.02 0.01 0.02 1.2e-03 7.2e-04 2.9e-02 1.3e-03
13 LHb mRNA stability Apip 0.35 0.23 6.9e-07 0.23 0.25 0.24 0.24 2.8e-06 1.3e-06 2.2e-06 2.1e-06
14 BLA mRNA stability Apip 0.46 0.18 0.0e+00 0.36 0.38 0.38 0.39 5.5e-20 8.4e-22 2.9e-21 4.0e-22
15 RMTg gene expression Apip 0.28 0.18 2.1e-06 0.19 0.18 0.15 0.18 8.6e-06 1.9e-05 6.7e-05 1.6e-05
16 BLA gene expression Apip 0.38 0.2 0.0e+00 0.32 0.32 0.31 0.32 1.3e-17 8.9e-18 4.9e-17 1.0e-17
17 OFC mRNA stability Apip 0.44 0.22 3.4e-09 0.32 0.32 0.32 0.32 2.5e-08 2.0e-08 3.1e-08 1.6e-08
18 NAcc gene expression Apip 0.42 0.16 0.0e+00 0.42 0.42 0.41 0.42 2.7e-52 1.6e-52 1.9e-51 3.8e-52
19 Brain gene expression Apip 0.17 0.09 0.0e+00 0.25 0.09 0.24 0.18 5.0e-23 5.9e-09 1.9e-22 3.0e-16
20 Brain mRNA stability Apip 0.27 0.14 0.0e+00 0.34 0.1 0.34 0.01 2.7e-32 5.9e-10 2.6e-32 1.7e-02
21 OFC gene expression Apip 0.39 0.23 3.4e-07 0.23 0.24 0.22 0.24 3.0e-06 2.6e-06 6.3e-06 1.8e-06
22 pVTA mRNA stability Apip 0.28 0.14 1.8e-15 0.3 0.31 0.32 0.31 1.8e-13 5.4e-14 2.3e-14 4.1e-14
23 PL mRNA stability Apip 0.39 0.26 0.0e+00 0.36 0.36 0.38 0.37 7.4e-42 1.4e-41 2.9e-44 2.8e-42

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Bone: apparent density0.71.11.4-1.0-1.0-1.0-1.11.11.2-1.1-1.1-1.11.01.01.01.01.0-1.11.01.10.9-1.0-1.01.0-1.1-0.9
Area under the delay curve0.30.30.50.60.60.60.5-0.5-0.70.50.50.5-0.7-0.6-0.5-0.6-0.60.3-0.6-0.6-0.60.70.7-0.60.60.5
BMI with tail0.20.61.0-1.0-1.0-1.0-0.40.71.0-0.3-0.3-0.30.90.70.70.70.9-0.50.70.70.9-1.0-1.00.8-0.8-0.6
BMI without tail0.51.11.8-1.1-1.1-1.1-0.81.01.1-0.8-0.8-0.81.21.01.01.11.1-0.91.01.21.0-1.3-1.31.2-0.9-1.0
Body weight0.52.34.0-2.0-1.9-1.9-1.41.41.9-1.3-1.3-1.31.61.41.51.41.5-1.51.41.21.7-1.5-1.51.3-1.3-0.9
Weight adjusted by age2.32.63.31.61.61.61.7-1.6-1.61.81.81.8-1.6-1.6-1.6-1.6-1.71.6-1.6-1.5-1.71.51.6-1.51.61.3
Bone surface0.51.01.5-1.0-1.0-1.0-1.21.01.0-1.2-1.2-1.20.80.91.00.90.9-1.10.90.80.9-0.7-0.90.7-0.9-0.7
Bone volume1.62.73.2-1.6-1.6-1.6-1.71.71.7-1.8-1.8-1.81.51.61.61.61.7-1.61.61.71.5-1.6-1.61.6-1.6-1.4
Breakpoint value in progressive ratio session1.51.62.21.31.31.31.5-1.3-1.21.51.51.5-1.3-1.2-1.3-1.2-1.31.3-1.2-1.2-1.31.21.2-1.21.10.9
Number of licking bursts0.10.10.5-0.4-0.4-0.4-0.50.40.3-0.6-0.6-0.60.20.40.40.30.2-0.70.40.10.4-0.2-0.20.1-0.2-0.2
Context. condit. distance diff. score2.32.84.1-1.6-1.6-1.6-2.01.71.6-1.9-1.9-1.91.91.61.71.61.7-2.01.71.51.6-1.6-1.51.4-0.8-1.3
Locomotion velocity, session 10.00.00.10.10.10.10.1-0.1-0.20.10.10.10.0-0.1-0.1-0.1-0.00.2-0.10.1-0.30.0-0.10.00.2-0.2
Locomotion distance, session 10.10.10.2-0.2-0.2-0.2-0.20.20.2-0.3-0.3-0.30.30.20.20.20.3-0.00.20.40.1-0.4-0.40.4-0.2-0.3
Locomotion velocity, session 20.00.00.10.20.20.2-0.1-0.1-0.2-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.2-0.0-0.1-0.2-0.3-0.00.1-0.10.30.1
Locomotion distance, session 20.30.50.7-0.7-0.7-0.7-0.70.70.7-0.7-0.7-0.70.60.70.70.70.7-0.40.70.70.7-0.8-0.70.7-0.8-0.5
Locomotion velocity, session 30.20.20.5-0.2-0.2-0.2-0.40.40.4-0.3-0.3-0.30.50.40.40.50.5-0.20.40.70.4-0.6-0.50.6-0.4-0.5
Locomotion distance, session 30.30.30.6-0.5-0.5-0.5-0.50.50.5-0.4-0.4-0.40.50.60.50.60.6-0.40.60.70.6-0.7-0.60.6-0.5-0.5
Stereotopy head waving bouts, day 30.00.00.10.10.10.10.20.0-0.20.20.20.20.10.10.00.10.20.30.10.30.1-0.0-0.10.20.0-0.2
Stereotopy head waving duration, day 30.40.40.7-0.5-0.5-0.5-0.70.70.5-0.7-0.7-0.70.70.70.70.70.7-0.70.70.80.5-0.5-0.60.7-0.5-0.7
Locomotion velocity, session 70.10.20.5-0.2-0.2-0.2-0.10.30.1-0.1-0.1-0.10.50.40.30.40.50.00.40.70.3-0.7-0.60.7-0.3-0.4
Locomotion distance, session 70.30.30.60.50.50.50.7-0.6-0.60.70.70.7-0.5-0.6-0.6-0.6-0.50.8-0.6-0.5-0.50.30.5-0.50.60.5
Stereotopy head waving bouts, day 70.00.00.2-0.0-0.0-0.0-0.50.10.0-0.4-0.4-0.40.20.10.10.10.2-0.30.10.10.1-0.1-0.10.00.1-0.1
Stereotopy head waving duration, day 70.00.00.10.10.10.1-0.40.0-0.1-0.3-0.3-0.30.00.00.00.00.1-0.20.0-0.0-0.10.0-0.0-0.00.0-0.1
Locomotion velocity, session 80.60.81.3-0.9-0.9-0.9-0.90.90.9-0.8-0.8-0.81.10.90.90.90.9-0.70.90.90.9-1.1-0.91.0-0.3-0.6
Locomotion distance, session 83.04.55.6-2.1-2.1-2.1-2.32.12.1-2.2-2.2-2.22.42.12.12.12.2-2.12.12.12.1-2.4-2.12.0-1.4-1.7
Degree of sensitization distance0.50.50.80.60.60.60.8-0.7-0.70.80.80.8-0.6-0.8-0.7-0.8-0.80.6-0.8-0.9-0.70.80.7-0.80.90.7
Degree of sensitization stereotypy0.00.00.10.10.10.1-0.3-0.1-0.1-0.2-0.2-0.20.0-0.1-0.1-0.1-0.0-0.1-0.1-0.2-0.10.00.0-0.20.30.1
Conditioned locomotion4.35.07.32.22.22.22.0-2.3-2.22.12.12.1-2.4-2.3-2.3-2.3-2.52.0-2.3-2.7-2.22.12.2-2.42.12.2
Cocaine response after cond. corrected2.22.53.21.61.61.61.8-1.6-1.61.81.81.8-1.6-1.6-1.6-1.5-1.51.8-1.6-1.5-1.41.41.4-1.51.31.4
Cocaine response after cond. not corrected0.50.50.70.70.70.70.8-0.7-0.70.80.80.8-0.7-0.7-0.7-0.7-0.70.7-0.7-0.8-0.70.70.6-0.80.60.7
Cocaine response before conditioning4.55.58.0-2.5-2.4-2.4-2.62.42.4-2.5-2.5-2.52.42.32.42.32.3-2.82.32.22.1-2.0-2.22.1-1.9-2.0
Saline control response0.81.11.5-1.0-1.1-1.1-1.01.01.1-0.9-0.9-0.91.11.01.01.01.0-1.11.01.10.8-1.2-1.21.1-0.9-1.0
Bone: connectivity density0.50.81.1-0.8-0.8-0.8-1.00.91.0-1.0-1.0-1.00.80.90.90.80.8-1.00.90.80.7-0.7-0.90.8-0.9-0.8
Bone: cortical apparent density0.10.10.30.10.20.20.0-0.3-0.20.00.00.0-0.3-0.3-0.3-0.3-0.30.6-0.3-0.40.00.40.5-0.40.40.4
Bone: cortical area0.10.10.2-0.4-0.4-0.4-0.30.30.4-0.4-0.4-0.40.20.20.30.20.2-0.40.20.00.40.0-0.1-0.0-0.30.1
Bone: cortical porosity0.60.60.90.80.80.80.8-0.8-0.80.80.80.8-0.7-0.8-0.8-0.8-0.80.7-0.8-0.8-0.80.90.8-0.81.00.6
Bone: cortical porosity0.40.40.70.50.60.60.6-0.6-0.60.60.60.6-0.5-0.6-0.6-0.6-0.70.4-0.6-0.7-0.60.70.7-0.70.80.5
Bone: cortical thickness0.00.00.20.00.00.00.0-0.1-0.00.00.00.0-0.2-0.1-0.1-0.1-0.10.1-0.1-0.20.00.40.3-0.30.00.2
Bone: cortical thickness4.35.07.02.22.12.12.1-2.2-2.12.02.02.0-2.3-2.3-2.2-2.3-2.42.0-2.3-2.7-2.12.42.3-2.52.12.2
Bone: cortical tissue density0.00.10.20.10.10.1-0.1-0.2-0.1-0.1-0.1-0.1-0.2-0.2-0.2-0.2-0.20.5-0.2-0.30.10.30.4-0.30.30.4
Condit. Reinf. active minus inactive responses1.01.12.0-0.9-0.9-0.9-1.31.10.9-1.2-1.2-1.20.91.11.11.01.0-1.41.11.00.9-0.9-0.91.0-1.0-0.8
Condit. Reinf. active-inactive response ratio2.12.23.9-1.4-1.4-1.4-2.01.61.4-1.8-1.8-1.81.31.51.61.41.3-2.01.51.21.4-1.2-1.31.2-1.4-1.1
Condit. Reinf. active responses0.30.30.7-0.4-0.4-0.4-0.80.70.4-0.8-0.8-0.80.40.60.70.60.5-0.90.60.50.5-0.5-0.40.5-0.6-0.4
Condit. Reinf. inactive responses0.40.40.70.70.70.70.8-0.7-0.70.70.70.7-0.7-0.6-0.7-0.6-0.70.8-0.6-0.6-0.60.60.7-0.50.50.6
Incentive salience index mean0.91.11.9-1.0-1.0-1.0-1.31.10.9-1.2-1.2-1.20.91.11.11.10.9-1.41.11.00.9-0.9-0.91.0-1.1-0.8
Condit. Reinf. lever presses0.81.11.5-1.0-1.0-1.0-1.11.11.0-1.1-1.1-1.10.91.01.11.00.9-1.21.00.90.9-1.1-0.91.0-1.1-0.8
Condit. Reinf. active minus inactive responses1.11.42.1-1.1-1.1-1.1-1.21.21.1-1.2-1.2-1.21.21.21.21.11.2-1.41.21.20.9-1.3-1.11.2-1.1-1.1
Condit. Reinf. active-inactive response ratio3.03.24.7-1.7-1.7-1.7-1.91.91.7-1.9-1.9-1.91.71.81.81.71.8-2.21.81.81.4-1.8-1.71.7-1.8-1.7
Condit. Reinf. active responses0.71.01.4-1.1-1.0-1.0-1.01.11.0-1.0-1.0-1.00.91.01.11.01.0-1.21.01.00.9-1.0-0.91.0-1.1-0.9
Condit. Reinf. inactive responses0.00.00.1-0.1-0.1-0.10.0-0.10.00.00.00.0-0.2-0.1-0.0-0.0-0.10.1-0.1-0.20.20.20.1-0.2-0.00.2
Condit. Reinf. lever presses0.50.71.1-0.8-0.8-0.8-0.80.90.8-0.9-0.9-0.90.70.80.90.80.9-1.00.81.00.5-0.6-0.70.8-1.0-0.9
Condit. Reinf. lever reinforcers received0.81.11.4-1.1-1.1-1.1-1.01.11.0-1.0-1.0-1.01.01.11.11.11.1-1.21.11.20.9-1.1-1.01.1-1.1-1.0
Conditioned reinforcement - actives3.53.53.9-1.9-1.8-1.8-2.01.91.8-1.9-1.9-1.91.91.91.91.91.9-1.71.91.91.9-1.8-1.81.8-1.6-1.7
Conditioned reinforcement - inactives9.110.211.5-3.2-3.1-3.1-3.43.33.2-3.3-3.3-3.33.33.33.33.33.3-3.23.33.13.1-3.2-3.22.9-2.8-3.0
Conditioned locomotion2.83.34.6-2.0-2.0-2.0-2.01.81.8-1.9-1.9-1.91.91.81.81.92.0-1.41.81.72.2-1.7-1.81.6-1.6-1.4
Patch foraging indifference point 0 sec0.20.30.50.40.40.40.6-0.5-0.50.60.60.6-0.5-0.5-0.5-0.5-0.70.6-0.5-0.6-0.50.50.6-0.50.50.5
Patch foraging indifference point AUC1.21.42.51.41.41.41.3-1.2-1.31.21.21.2-1.1-1.2-1.3-1.1-0.91.6-1.2-0.8-1.21.31.1-1.00.90.8
Delay disc. indifference point, 0s delay0.00.00.10.10.10.10.0-0.1-0.2-0.0-0.0-0.0-0.2-0.1-0.1-0.1-0.2-0.1-0.10.3-0.10.20.20.20.20.2
Delay disc. indifference point, 16s delay2.12.12.41.41.51.51.5-1.4-1.51.51.51.5-1.5-1.5-1.4-1.5-1.41.4-1.5-1.5-1.51.51.5-1.51.31.2
Delay disc. indifference point, 2s delay0.50.50.70.80.80.80.6-0.7-0.80.70.70.7-0.8-0.7-0.7-0.7-0.80.4-0.7-0.5-0.90.70.8-0.50.80.5
Delay disc. indifference point, 24s delay0.40.40.80.50.70.70.6-0.6-0.70.60.60.6-0.6-0.6-0.6-0.6-0.50.5-0.6-0.8-0.70.70.6-0.90.20.4
Delay disc. indifference point, 4s delay0.30.30.60.60.60.60.5-0.5-0.60.50.50.5-0.7-0.6-0.5-0.6-0.70.2-0.6-0.5-0.60.60.7-0.40.80.5
Delay disc. indifference point, 8s delay0.10.10.3-0.4-0.3-0.3-0.50.40.3-0.5-0.5-0.50.30.40.40.40.3-0.50.40.30.3-0.3-0.20.3-0.2-0.4
Indifference point function ln k0.60.91.9-1.2-1.2-1.2-1.01.01.1-1.0-1.0-1.00.80.91.00.80.6-1.40.90.31.0-0.8-0.80.6-0.7-0.4
Indifference point function log k0.60.91.9-1.2-1.2-1.2-1.01.01.1-1.0-1.0-1.00.80.91.00.80.6-1.40.90.31.0-0.8-0.80.6-0.7-0.4
Patch foraging total patch changes 0 sec0.10.20.30.30.30.30.5-0.4-0.40.40.40.4-0.4-0.4-0.4-0.4-0.50.5-0.4-0.5-0.40.40.5-0.40.40.4
Patch foraging total patch changes 12 sec0.10.20.6-0.4-0.4-0.4-0.30.40.4-0.3-0.3-0.30.60.40.40.50.5-0.00.40.70.3-0.4-0.40.6-0.4-0.6
Patch foraging total patch changes 18 sec0.40.50.90.80.90.90.6-0.7-0.80.50.50.5-0.7-0.7-0.7-0.7-0.70.9-0.7-0.6-0.70.90.8-0.70.60.6
Patch foraging total patch changes 24 sec1.01.22.11.01.11.11.2-1.2-1.11.21.21.2-0.9-1.2-1.2-1.1-0.81.3-1.2-0.9-1.21.51.0-1.10.80.8
Patch foraging total patch changes 6 sec0.20.20.60.50.60.60.6-0.5-0.60.50.50.5-0.3-0.4-0.5-0.4-0.30.8-0.5-0.1-0.60.40.4-0.20.30.1
Patch foraging time to switch 0 sec0.00.00.10.00.10.10.10.0-0.00.10.10.10.10.10.00.10.00.20.10.3-0.1-0.1-0.00.30.0-0.3
Patch foraging water rate 0 sec0.00.00.3-0.1-0.0-0.00.1-0.10.00.10.10.1-0.2-0.1-0.1-0.2-0.3-0.1-0.1-0.50.10.10.2-0.40.10.4
Patch foraging water rate 12 sec0.30.51.20.50.50.50.6-0.7-0.50.50.50.5-0.7-0.7-0.6-0.8-0.70.2-0.7-1.1-0.70.80.7-1.00.50.9
Patch foraging water rate 18 sec0.60.81.5-1.0-1.1-1.1-0.90.91.1-0.8-0.8-0.80.80.80.90.80.9-1.20.80.60.9-0.5-0.80.5-0.8-0.6
Patch foraging water rate 24 sec0.30.41.00.50.50.50.5-0.6-0.60.50.50.5-0.7-0.7-0.6-0.7-0.6-0.0-0.6-1.0-0.70.90.7-1.00.40.6
Patch foraging water rate 6 sec0.10.10.40.1-0.0-0.00.2-0.20.00.20.20.2-0.3-0.3-0.2-0.3-0.2-0.1-0.3-0.6-0.10.40.2-0.60.10.3
Seeking ratio, delayed vs. immediate footshock0.20.30.5-0.4-0.5-0.5-0.40.50.7-0.5-0.5-0.50.60.50.50.50.5-0.50.50.70.4-0.7-0.60.7-0.5-0.5
Distance traveled before self-admin0.60.61.1-1.1-1.0-1.0-0.70.80.9-0.7-0.7-0.70.80.80.80.80.7-0.70.80.61.1-0.7-0.70.7-0.7-0.5
Distance traveled after self-admin0.50.50.7-0.9-0.8-0.8-0.80.70.7-0.7-0.7-0.70.70.80.70.80.7-0.60.70.70.8-0.6-0.70.7-0.6-0.6
Extensor digitorum longus weight0.41.52.01.11.21.21.2-1.2-1.21.31.31.3-1.3-1.2-1.2-1.2-1.21.1-1.2-1.3-1.11.41.2-1.30.91.1
Bone: elastic displacement1.92.23.51.51.51.51.6-1.5-1.51.61.61.6-1.5-1.5-1.5-1.5-1.41.3-1.5-1.4-1.61.91.4-1.61.21.1
Bone: elastic work1.52.02.81.41.41.41.7-1.4-1.31.61.61.6-1.4-1.4-1.4-1.4-1.31.3-1.4-1.3-1.41.71.3-1.41.01.0
Bone: endosteal estimation0.20.51.10.60.60.60.7-0.7-0.50.50.50.5-0.8-0.8-0.7-0.8-0.80.5-0.8-1.0-0.60.50.7-0.90.50.9
Bone: endosteal perimeter0.30.50.9-0.8-0.8-0.8-0.70.70.9-0.8-0.8-0.80.60.70.70.60.7-0.80.70.50.7-0.9-0.70.6-0.7-0.4
Epididymis fat weight0.81.92.3-1.4-1.3-1.3-1.41.41.3-1.4-1.4-1.41.41.31.41.31.5-1.41.41.41.3-1.4-1.51.3-1.3-1.2
Delta time in closed arm before/after self-admin0.00.00.1-0.2-0.2-0.2-0.30.00.2-0.3-0.3-0.30.10.10.00.10.00.30.0-0.00.4-0.1-0.10.00.20.2
Delta time in open arm before/after self-admin0.40.30.60.60.70.70.4-0.5-0.80.50.50.5-0.8-0.5-0.5-0.6-0.70.2-0.5-0.7-0.60.50.7-0.70.50.5
Diff in mean of infusions in LGA sessions0.40.40.60.70.70.70.8-0.6-0.60.70.70.7-0.7-0.6-0.6-0.6-0.80.4-0.6-0.7-0.70.60.8-0.60.80.4
Delay discount exponential model param0.40.40.6-0.6-0.7-0.7-0.60.60.7-0.6-0.6-0.60.80.60.60.70.7-0.40.60.60.7-0.7-0.80.6-0.7-0.5
Extinction: sum of active levers before priming0.30.30.8-0.7-0.7-0.7-0.20.50.6-0.5-0.5-0.50.70.60.50.60.7-0.10.50.60.9-0.6-0.70.6-0.4-0.4
Active lever presses in extinction session 60.40.40.8-0.7-0.7-0.7-0.20.50.9-0.4-0.4-0.40.80.60.50.60.8-0.30.60.70.6-0.6-0.90.6-0.7-0.6
Bone: final force0.00.00.00.10.10.10.2-0.1-0.10.10.10.1-0.1-0.1-0.1-0.1-0.00.1-0.1-0.1-0.1-0.10.2-0.10.10.1
Bone: final moment0.10.20.20.40.40.40.5-0.4-0.40.40.40.4-0.4-0.4-0.4-0.4-0.30.4-0.4-0.4-0.40.30.5-0.40.40.4
Food consumed during 24 hour testing period6.78.19.0-2.9-2.9-2.9-2.82.92.9-2.9-2.9-2.92.92.92.92.92.9-2.92.93.02.8-2.7-2.82.8-2.5-2.5
Glucose2.03.03.9-1.6-1.6-1.6-1.61.81.7-1.6-1.6-1.61.81.81.81.81.8-1.71.82.01.7-1.7-1.81.8-1.5-1.6
Heart weight0.50.71.51.00.80.80.8-0.9-0.80.80.80.8-0.8-0.9-0.9-1.0-0.60.5-0.9-0.9-1.21.00.8-1.10.60.5
Delay discount hyperbolic model param0.30.30.5-0.6-0.6-0.6-0.50.50.7-0.6-0.6-0.60.70.60.50.60.7-0.30.60.50.6-0.7-0.70.5-0.7-0.5
Intermittent access intake day 1-15 change0.10.10.2-0.3-0.3-0.3-0.30.30.4-0.3-0.3-0.30.30.30.30.30.3-0.40.3-0.10.3-0.2-0.3-0.1-0.4-0.1
Intermittent access intake escalation0.30.30.5-0.7-0.7-0.7-0.50.60.6-0.5-0.5-0.50.60.60.60.60.6-0.70.60.20.6-0.4-0.60.1-0.7-0.4
Intermittent access intake escalation 22.32.33.0-1.6-1.6-1.6-1.51.61.5-1.6-1.6-1.61.51.51.61.51.5-1.71.51.21.5-1.3-1.41.2-1.4-1.2
Intermitt. access day 1 inactive lever presses0.00.00.20.0-0.0-0.00.0-0.2-0.00.00.00.0-0.2-0.2-0.2-0.2-0.30.1-0.2-0.4-0.00.20.2-0.30.40.4
Intermitt. access day 15 inactive lever presses3.63.95.0-2.1-2.1-2.1-2.11.92.0-2.1-2.1-2.12.02.01.92.02.0-1.71.92.22.2-1.7-1.92.0-1.4-1.5
Intermitt. access escalation Index0.10.00.4-0.0-0.0-0.0-0.30.20.0-0.3-0.3-0.30.10.20.20.10.1-0.60.2-0.0-0.2-0.2-0.1-0.0-0.2-0.3
Intermittent access day 1 total infusions3.84.45.3-2.3-2.2-2.2-2.22.12.1-2.1-2.1-2.12.12.12.12.22.1-1.92.12.22.3-2.0-2.02.0-1.7-1.8
Intermittent access day 15 total infusions4.75.36.2-2.5-2.4-2.4-2.32.42.4-2.3-2.3-2.32.42.42.42.42.4-2.32.42.22.4-2.2-2.22.1-2.0-2.0
Intermittent access terminal intake (last 3 days)6.36.97.7-2.8-2.7-2.7-2.72.72.7-2.6-2.6-2.62.72.72.72.72.6-2.72.72.72.7-2.5-2.52.5-2.2-2.3
Intermittent access total infusions6.26.87.8-2.8-2.7-2.7-2.72.72.7-2.6-2.6-2.62.62.72.72.72.6-2.72.72.62.7-2.5-2.52.5-2.1-2.3
Intermittent access day 1 locomotion1.71.82.6-1.6-1.5-1.5-1.51.31.4-1.4-1.4-1.41.31.41.31.41.3-1.21.31.21.6-1.2-1.21.1-1.2-1.0
Intermittent access day 15 total locomotion2.62.83.8-1.9-1.8-1.8-1.81.61.7-1.7-1.7-1.71.71.71.61.71.8-1.31.71.62.0-1.5-1.61.4-1.6-1.3
Intermittent access total locomotion2.83.24.5-2.1-2.0-2.0-1.81.81.8-1.7-1.7-1.71.81.81.81.91.8-1.61.81.52.1-1.7-1.71.4-1.7-1.4
Intermittent access standard deviation6.26.68.0-2.8-2.8-2.8-2.42.62.8-2.5-2.5-2.52.62.62.72.72.6-2.52.62.52.8-2.5-2.52.5-2.0-2.1
Left kidney weight0.61.72.7-1.6-1.6-1.6-1.31.21.5-1.3-1.3-1.31.41.21.21.31.4-1.01.21.11.6-1.2-1.31.1-0.9-0.8
Right kidney weight0.61.82.7-1.6-1.6-1.6-1.21.21.4-1.2-1.2-1.21.51.21.21.31.6-0.81.21.41.6-1.4-1.41.2-1.1-1.0
Cocaine induced anxiety0.30.30.5-0.6-0.6-0.6-0.70.50.6-0.7-0.7-0.70.50.50.50.50.4-0.60.50.60.6-0.6-0.50.6-0.1-0.3
Post-drug Anxiety0.00.00.30.00.00.0-0.00.0-0.0-0.0-0.0-0.0-0.00.00.00.00.00.00.00.60.1-0.00.00.50.3-0.0
Baseline Anxiety2.42.53.21.71.71.71.8-1.6-1.71.81.81.8-1.6-1.6-1.6-1.6-1.51.7-1.6-1.2-1.61.61.6-1.21.41.3
Tail length0.41.11.4-1.2-1.1-1.1-1.01.01.1-1.1-1.1-1.11.11.01.01.01.2-1.01.01.01.0-1.2-1.21.0-1.0-0.8
Length with tail0.31.11.9-1.4-1.3-1.3-1.21.01.3-1.3-1.3-1.30.90.91.00.90.8-1.30.90.51.2-0.8-0.80.5-0.7-0.4
Length without tail0.20.40.8-0.9-0.8-0.8-0.70.60.9-0.7-0.7-0.70.50.50.60.50.4-0.80.50.10.8-0.2-0.30.1-0.3-0.1
Times rat made contact with spout0.10.20.2-0.4-0.4-0.4-0.30.40.3-0.4-0.4-0.40.40.40.40.40.3-0.40.40.40.4-0.3-0.40.4-0.3-0.3
Lifetime Intake6.47.28.2-2.9-2.8-2.8-2.82.82.7-2.7-2.7-2.72.72.82.82.82.6-2.82.82.62.8-2.6-2.62.5-2.2-2.3
Liver weight, left0.10.20.3-0.3-0.4-0.4-0.40.50.4-0.5-0.5-0.50.50.50.50.40.5-0.50.50.60.3-0.5-0.60.5-0.5-0.6
Liver weight, right0.91.52.0-1.3-1.3-1.3-1.21.31.3-1.2-1.2-1.21.21.31.31.31.2-1.31.31.21.4-1.0-1.11.1-0.9-1.1
Locomotor activity0.00.00.1-0.2-0.1-0.1-0.20.2-0.0-0.2-0.2-0.20.20.10.10.10.3-0.30.10.2-0.10.0-0.20.0-0.3-0.3
Locomotor testing distance1.01.62.2-1.3-1.2-1.2-1.21.31.2-1.2-1.2-1.21.41.21.31.21.5-1.51.31.41.0-1.2-1.41.3-1.3-1.2
Locomotor testing rearing0.10.10.3-0.2-0.3-0.3-0.20.30.3-0.3-0.3-0.30.40.30.30.20.5-0.40.30.30.1-0.5-0.50.3-0.5-0.4
Locomotion in novel chamber0.60.71.0-0.9-0.9-0.9-0.80.91.0-0.6-0.6-0.60.90.90.90.90.8-1.00.90.90.9-0.9-0.91.0-0.7-0.7
Locomotion in novel chamber post-restriction1.31.51.91.31.41.41.2-1.2-1.31.21.21.2-1.3-1.3-1.2-1.3-1.20.9-1.2-1.3-1.41.11.2-1.31.01.1
Fecal boli incidents, locomotor time 19.510.411.93.23.43.43.1-3.2-3.33.13.13.1-3.5-3.3-3.2-3.3-3.42.9-3.3-3.3-3.23.43.4-3.23.02.9
Change in fecal boli incidents, locomotor task7.47.08.0-2.7-2.8-2.8-2.52.72.7-2.6-2.6-2.62.82.82.72.82.7-2.22.72.52.8-2.7-2.72.4-2.4-2.4
Time >=10cm from walls, locomotor time 10.20.20.30.50.50.50.4-0.4-0.50.50.50.5-0.4-0.4-0.4-0.4-0.30.2-0.4-0.5-0.50.50.4-0.50.10.3
Bouts of movement, locomotor time 11.21.32.71.11.11.11.1-1.1-1.21.11.11.1-1.4-1.2-1.1-1.2-1.41.0-1.1-0.7-1.21.21.3-0.61.71.0
Total resting periods, locomotor time 11.11.22.41.01.11.10.9-1.1-1.11.01.01.0-1.3-1.1-1.0-1.1-1.30.9-1.1-0.6-1.11.21.2-0.61.51.0
Rest time, locomotor task time 10.70.81.20.80.90.90.8-0.8-0.90.80.80.8-1.1-0.9-0.8-0.9-1.00.8-0.8-1.0-0.90.91.0-0.91.10.7
Distance moved, locomotor task time 12.42.63.1-1.5-1.7-1.7-1.61.61.8-1.7-1.7-1.71.71.71.61.71.6-1.61.61.41.7-1.7-1.61.4-1.5-1.3
Vertical activity count, locomotor time 10.20.20.3-0.4-0.5-0.5-0.50.40.4-0.6-0.6-0.60.50.40.40.40.4-0.40.40.30.5-0.4-0.50.3-0.5-0.3
Time >=10cm from walls, locomotor time 25.86.27.2-2.4-2.5-2.5-2.52.62.5-2.5-2.5-2.52.62.52.62.52.6-2.72.52.32.4-2.4-2.52.2-2.5-2.2
Bouts of movement, locomotor time 20.10.10.20.20.10.10.3-0.3-0.40.30.30.3-0.2-0.3-0.3-0.3-0.00.4-0.3-0.1-0.20.30.2-0.20.30.3
Total resting periods, locomotor time 20.00.00.10.10.10.10.2-0.3-0.30.20.20.2-0.1-0.3-0.3-0.20.10.3-0.30.1-0.20.20.1-0.00.20.2
Rest time, locomotor task time 22.12.42.71.51.61.61.5-1.6-1.51.51.51.5-1.6-1.6-1.6-1.6-1.61.6-1.6-1.6-1.51.51.5-1.51.51.4
Distance moved, locomotor task time 24.04.75.4-2.1-2.2-2.2-2.12.22.3-2.2-2.2-2.22.22.22.22.22.1-2.32.22.12.1-2.2-2.12.1-1.9-1.9
Vertical activity count, locomotor time 22.62.93.2-1.6-1.8-1.8-1.81.71.7-1.8-1.8-1.81.81.71.71.71.7-1.61.71.61.7-1.7-1.71.6-1.6-1.4
Light reinforcement 10.20.40.8-0.6-0.7-0.7-0.50.60.9-0.4-0.4-0.40.80.60.60.60.6-0.30.60.70.7-0.6-0.70.8-0.5-0.5
Light reinforcement 20.00.00.2-0.3-0.4-0.4-0.10.10.4-0.1-0.1-0.10.20.20.10.2-0.10.00.10.00.40.1-0.00.10.10.0
Bone: marrow area0.20.51.00.60.60.60.7-0.7-0.50.60.60.6-0.7-0.8-0.7-0.8-0.80.5-0.7-1.0-0.60.50.6-0.80.50.8
Bone: maximum diameter0.10.20.4-0.5-0.5-0.5-0.50.40.6-0.6-0.6-0.60.30.40.40.40.3-0.60.40.10.5-0.3-0.30.2-0.4-0.1
Bone: maximum force0.00.00.1-0.3-0.3-0.3-0.10.20.3-0.2-0.2-0.20.20.20.20.20.2-0.20.10.00.3-0.2-0.10.1-0.20.0
Bone: maximum moment0.00.10.10.10.10.10.4-0.3-0.10.30.30.3-0.2-0.3-0.3-0.3-0.20.3-0.3-0.4-0.20.30.4-0.40.20.4
Mean time between licks in bursts1.11.52.31.11.11.11.1-1.2-1.11.21.21.2-1.3-1.2-1.2-1.3-1.31.1-1.2-1.5-1.11.41.3-1.51.11.2
Mean num. licks in bursts0.00.00.1-0.1-0.1-0.10.10.10.20.10.10.10.30.10.10.20.20.20.10.40.1-0.3-0.20.4-0.2-0.2
Cd content in liver1.51.72.9-1.2-1.2-1.2-1.01.41.3-1.0-1.0-1.01.41.41.31.41.4-1.21.41.71.1-1.4-1.41.5-1.1-1.4
Co content in liver1.61.82.61.41.41.41.3-1.3-1.51.31.31.3-1.4-1.3-1.3-1.3-1.31.1-1.3-1.3-1.41.61.4-1.41.21.0
Cu content in liver0.60.71.40.70.70.70.8-0.8-0.60.80.80.8-0.9-0.9-0.8-0.9-0.90.5-0.9-1.2-0.80.80.9-1.00.70.9
Fe content in liver0.81.02.01.21.21.20.8-1.0-1.40.80.80.8-1.1-1.0-1.0-1.0-1.10.7-1.0-1.0-1.30.81.0-0.90.80.6
K content in liver1.91.92.91.31.31.31.7-1.4-1.41.71.71.7-1.3-1.3-1.4-1.3-1.31.7-1.3-1.3-1.11.21.3-1.31.31.2
Mg content in liver2.12.12.81.41.41.41.7-1.5-1.41.71.71.7-1.5-1.5-1.5-1.5-1.51.4-1.5-1.6-1.41.21.3-1.41.31.3
Mn content in liver1.82.12.31.51.51.51.5-1.5-1.31.51.51.5-1.5-1.5-1.5-1.5-1.51.5-1.5-1.5-1.51.21.3-1.41.31.2
Na content in liver0.10.10.30.30.30.30.3-0.4-0.40.30.30.3-0.4-0.4-0.4-0.4-0.40.2-0.4-0.5-0.40.40.5-0.60.40.4
Rb content in liver1.31.62.11.41.41.41.4-1.2-1.51.41.41.4-1.2-1.2-1.3-1.2-1.21.3-1.2-1.0-1.41.01.1-0.91.10.9
Se content in liver4.05.06.12.32.32.32.2-2.2-2.22.22.22.2-2.4-2.3-2.2-2.3-2.41.9-2.3-2.5-2.32.02.3-2.31.91.9
Sr content in liver0.30.30.70.30.30.30.2-0.5-0.20.20.20.2-0.6-0.5-0.5-0.5-0.60.3-0.5-0.8-0.30.80.7-0.80.50.7
Zn content in liver0.10.20.30.40.40.40.4-0.4-0.40.40.40.4-0.4-0.4-0.4-0.4-0.40.4-0.4-0.4-0.30.50.5-0.40.40.3
Bone: minimum diameter0.40.71.2-1.0-1.0-1.0-0.80.91.0-0.9-0.9-0.90.80.80.90.80.8-1.10.80.51.0-0.7-0.80.5-0.8-0.4
Time in familiar zone, hab. session 10.50.50.80.70.70.70.6-0.7-0.60.60.60.6-0.5-0.7-0.7-0.7-0.60.9-0.7-0.6-0.60.80.7-0.70.80.6
Time in novel zone, hab. session 10.90.91.6-1.0-1.0-1.0-0.91.00.9-0.9-0.9-0.90.80.91.00.90.8-1.30.90.80.8-1.0-0.90.9-1.1-0.8
Total zone transitions, hab. session 12.53.54.2-1.9-1.9-1.9-2.01.91.8-2.1-2.1-2.12.01.91.91.92.0-1.71.92.01.8-1.7-1.81.8-1.5-1.6
Total locomotion distance, hab. session 11.11.52.4-1.3-1.3-1.3-1.51.21.1-1.6-1.6-1.61.31.21.21.21.2-1.01.21.21.4-0.9-1.11.0-0.8-0.9
Locomotion velocity, hab. session 10.71.01.7-1.0-1.0-1.0-1.21.01.0-1.3-1.3-1.31.21.01.01.01.0-0.71.01.01.2-0.8-0.90.9-0.6-0.7
Time in familiar zone, hab. session 20.00.00.2-0.3-0.3-0.3-0.10.20.3-0.1-0.1-0.10.20.20.20.20.30.10.20.20.50.0-0.10.1-0.3-0.0
Time in novel zone, hab. session 20.00.00.10.10.10.1-0.00.0-0.1-0.0-0.0-0.0-0.0-0.00.0-0.1-0.1-0.3-0.0-0.1-0.4-0.2-0.10.10.1-0.1
Total zone transitions, hab. session 22.02.63.2-1.7-1.7-1.7-1.41.61.7-1.5-1.5-1.51.71.71.61.71.7-1.31.61.81.7-1.6-1.61.7-1.6-1.4
Total locomotion distance, hab. session 20.00.10.3-0.3-0.3-0.3-0.10.20.3-0.2-0.2-0.20.30.20.20.20.30.10.20.20.5-0.1-0.20.10.0-0.0
Locomotion velocity, hab. session 20.00.00.2-0.3-0.3-0.3-0.00.10.3-0.1-0.1-0.10.30.10.10.20.20.20.10.10.5-0.0-0.10.10.10.1
Novel to familiar place preference ratio1.01.01.3-1.0-1.0-1.0-0.91.00.9-0.9-0.9-0.91.01.01.01.11.1-0.81.01.11.1-1.1-1.01.1-0.9-0.8
Novelty place preference0.90.91.3-0.9-0.9-0.9-0.91.00.9-0.9-0.9-0.91.01.01.01.01.0-0.81.01.11.1-1.1-1.01.1-0.8-0.7
Time in novel zone, NPP test0.60.60.8-0.7-0.7-0.7-0.80.80.7-0.8-0.8-0.80.80.80.80.80.9-0.70.80.90.8-0.9-0.80.9-0.7-0.7
Total zone transitions, NPP test0.40.61.00.90.90.90.7-0.8-1.00.60.60.6-0.8-0.8-0.8-0.8-0.70.8-0.8-0.6-1.01.00.9-0.80.70.5
Total locomotion distance, NPP test0.40.50.90.70.70.70.5-0.7-0.70.50.50.5-0.6-0.7-0.7-0.7-0.70.8-0.7-0.7-0.61.00.8-0.80.90.6
Locomotion velocity, NPP test0.20.30.60.50.50.50.5-0.6-0.60.50.50.5-0.4-0.6-0.6-0.5-0.50.7-0.6-0.5-0.40.70.6-0.60.80.6
Intraocular pressure0.00.00.10.10.00.00.00.1-0.1-0.0-0.0-0.00.10.10.10.10.2-0.00.10.3-0.0-0.1-0.10.20.0-0.3
Delta distance traveled before/after self-admin0.20.20.40.60.60.60.2-0.5-0.60.30.30.3-0.5-0.5-0.5-0.5-0.30.6-0.5-0.4-0.60.60.5-0.50.50.4
Delta ambulatory time before/after self-admin0.10.20.30.40.40.40.0-0.4-0.50.20.20.2-0.4-0.4-0.4-0.4-0.30.3-0.4-0.4-0.40.50.5-0.50.50.4
Parametrial fat weight1.01.93.1-1.3-1.3-1.3-1.01.41.5-1.1-1.1-1.11.61.41.31.41.8-1.11.41.71.3-1.5-1.71.5-1.5-1.4
Pavlov. Cond. lever latency0.50.70.90.80.80.80.8-0.8-0.80.80.80.8-0.9-0.9-0.8-0.9-0.80.8-0.8-1.0-0.70.80.9-1.00.70.8
Pavlov. Cond. magazine entry latency1.11.41.8-1.2-1.2-1.2-1.11.21.2-1.0-1.0-1.01.21.21.21.21.2-1.01.21.41.2-1.2-1.31.3-1.1-1.1
Pavlov. Cond. change in total contacts0.10.10.20.20.20.20.5-0.4-0.20.50.50.5-0.4-0.3-0.4-0.3-0.40.5-0.4-0.5-0.30.30.2-0.30.20.4
Pavlov. Cond. index score0.40.60.8-0.8-0.8-0.8-0.70.70.8-0.6-0.6-0.60.80.80.70.80.8-0.50.70.90.8-0.8-0.90.9-0.7-0.6
Pavlov. Cond. latency score0.50.60.9-0.9-0.8-0.8-0.70.70.9-0.7-0.7-0.70.80.80.70.80.8-0.50.80.90.9-0.8-0.90.9-0.8-0.7
Pavlov. Cond. lever contacts0.30.40.6-0.7-0.7-0.7-0.80.60.6-0.7-0.7-0.70.60.60.60.60.5-0.60.60.60.5-0.6-0.60.6-0.5-0.5
Pavlov. Cond. magazine entry number1.11.31.91.21.21.21.0-1.2-1.21.01.01.0-1.2-1.2-1.1-1.2-1.20.9-1.2-1.4-1.21.11.2-1.31.11.1
Pavlov. Cond. intertrial magazine entries0.10.10.20.30.30.30.3-0.2-0.30.30.30.3-0.2-0.2-0.2-0.2-0.2-0.0-0.2-0.2-0.40.30.3-0.30.40.1
Pavlov. Cond. lever-magazine prob. diff.0.40.40.7-0.7-0.7-0.7-0.60.60.7-0.6-0.6-0.60.70.70.60.70.7-0.40.70.80.7-0.7-0.80.8-0.7-0.6
Pavlov. Cond. response bias0.81.01.3-1.0-1.0-1.0-1.01.01.0-1.0-1.0-1.01.11.11.01.11.0-0.91.01.11.0-1.0-1.11.1-0.9-0.9
Pavlov. Cond. lever latency2.22.93.91.61.61.61.6-1.8-1.61.71.71.7-1.7-1.7-1.7-1.7-1.81.9-1.7-2.0-1.31.81.7-1.91.71.8
Pavlov. Cond. magazine entry latency1.01.21.6-1.1-1.1-1.1-1.01.11.1-1.0-1.0-1.01.01.11.11.11.1-1.01.11.21.0-1.2-1.01.1-1.3-1.0
Pavlov. Cond. change in total contacts1.01.31.8-1.1-1.1-1.1-1.11.21.1-1.2-1.2-1.21.11.21.21.11.2-1.31.21.30.9-1.1-1.11.2-1.2-1.2
Pavlov. Cond. index score2.02.53.1-1.6-1.6-1.6-1.51.61.5-1.6-1.6-1.61.51.61.61.61.6-1.71.61.71.3-1.6-1.51.7-1.7-1.6
Pavlov. Cond. latency score2.53.13.7-1.7-1.7-1.7-1.61.81.7-1.7-1.7-1.71.61.81.81.81.8-1.91.81.91.5-1.8-1.71.8-1.8-1.7
Pavlov. Cond. lever contacts2.43.24.3-1.7-1.7-1.7-1.81.91.7-1.9-1.9-1.91.81.81.81.81.8-2.11.82.01.4-1.7-1.71.9-1.7-1.8
Pavlov. Cond. magazine entry number0.60.71.10.80.80.80.7-0.8-0.80.80.80.8-0.7-0.9-0.8-0.9-0.90.8-0.8-1.0-0.70.80.7-0.91.10.8
Pavlov. Cond. intertrial magazine entries0.10.10.30.50.50.50.3-0.3-0.50.30.30.3-0.2-0.3-0.3-0.3-0.30.3-0.3-0.2-0.40.20.1-0.20.40.2
Pavlov. Cond. lever-magazine prob. diff.1.62.12.6-1.4-1.4-1.4-1.41.51.4-1.5-1.5-1.51.31.51.51.41.4-1.61.51.61.2-1.4-1.31.5-1.5-1.4
Pavlov. Cond. response bias1.82.53.1-1.5-1.5-1.5-1.51.61.5-1.6-1.6-1.61.51.61.61.61.6-1.71.61.81.2-1.6-1.51.6-1.6-1.6
Time in closed arm before self-admin0.80.92.6-0.8-0.8-0.8-0.81.10.9-0.8-0.8-0.80.91.01.10.90.9-1.61.00.90.6-0.9-0.80.9-0.8-1.1
Time in closed arm after self-admin0.40.40.7-0.6-0.6-0.6-0.80.60.7-0.8-0.8-0.80.50.60.60.60.5-0.80.60.50.6-0.4-0.50.5-0.3-0.5
Time in open arm before self-admin0.91.02.00.90.90.91.1-1.1-0.81.01.01.0-0.9-1.1-1.1-1.0-0.81.4-1.1-1.0-0.91.00.8-1.00.81.0
Time in open arm after self-admin1.61.82.31.31.31.31.4-1.4-1.51.41.41.4-1.3-1.4-1.4-1.3-1.31.5-1.3-1.3-1.31.31.3-1.31.01.2
Bone: periosteal estimation0.10.10.50.20.20.20.3-0.4-0.10.20.20.2-0.4-0.4-0.3-0.4-0.40.2-0.4-0.7-0.20.40.4-0.60.20.6
Bone: periosteal perimeter1.01.72.1-1.4-1.4-1.4-1.21.31.5-1.3-1.3-1.31.31.31.31.31.3-1.21.31.21.5-1.4-1.31.2-1.3-0.9
Bone: post-yield work0.00.00.10.10.10.10.0-0.1-0.1-0.0-0.0-0.0-0.1-0.1-0.1-0.1-0.3-0.0-0.1-0.3-0.10.00.2-0.20.20.2
Progressive ratio test 1 active lever presses4.04.14.8-2.2-2.2-2.2-2.12.12.2-2.0-2.0-2.02.12.12.12.12.0-1.92.11.92.2-2.1-2.01.9-1.7-1.7
Progressive ratio test 1 breakpoint3.63.84.4-2.1-2.1-2.1-2.02.02.1-1.9-1.9-1.92.02.02.02.02.0-1.91.91.82.1-1.9-1.91.8-1.6-1.6
Progressive ratio test 1 inactive lever presses2.22.42.9-1.7-1.7-1.7-1.71.61.7-1.6-1.6-1.61.61.61.61.61.6-1.41.61.51.7-1.4-1.51.4-1.2-1.3
Progressive ratio test 2 active lever presses3.03.24.0-1.9-1.9-1.9-1.81.91.8-1.8-1.8-1.81.91.91.91.91.8-1.61.91.62.0-1.8-1.81.6-1.5-1.6
Progressive ratio test 2 breakpoint3.54.04.6-2.1-2.0-2.0-2.02.12.0-2.0-2.0-2.02.02.12.12.12.0-1.92.11.92.1-2.0-2.01.8-1.6-1.8
Progressive ratio test 2 inactive lever presses4.04.65.8-2.3-2.3-2.3-2.32.22.2-2.3-2.3-2.32.22.22.22.22.1-2.02.21.92.4-2.1-2.11.8-1.7-1.7
Incentive Sensitization - Responses1.41.41.9-1.1-1.1-1.1-1.11.31.2-1.2-1.2-1.21.31.31.21.31.2-1.01.31.21.2-1.4-1.31.2-1.0-1.3
Incentive Sensitization - Breakpoint1.21.21.7-1.1-1.0-1.0-1.01.21.1-1.1-1.1-1.11.21.21.21.21.1-0.91.21.11.1-1.3-1.21.0-0.9-1.2
Sum of active levers in priming session hrs 5-60.40.41.20.50.50.50.8-0.7-0.50.70.70.7-0.6-0.7-0.7-0.6-0.61.1-0.7-0.6-0.40.60.5-0.60.60.7
Progressive ratio0.50.50.8-0.7-0.7-0.7-0.70.70.8-0.8-0.8-0.80.80.80.70.80.7-0.50.80.70.9-0.9-0.70.7-0.5-0.6
Food seeking constrained by brief footshock1.21.51.9-1.4-1.3-1.3-1.31.21.4-1.2-1.2-1.21.31.31.21.31.2-1.11.21.11.3-1.3-1.31.1-1.0-1.0
Seeking ratio, punishment vs. effort0.10.20.30.30.40.40.3-0.4-0.40.50.50.5-0.4-0.4-0.4-0.4-0.40.3-0.4-0.5-0.50.50.4-0.50.30.4
Retroperitoneal fat weight8.728.732.8-5.5-5.5-5.5-5.45.55.5-5.4-5.4-5.45.55.45.55.45.5-5.75.45.55.2-5.1-5.35.1-4.9-4.7
Reaction time number correct0.00.00.20.10.10.10.20.0-0.00.30.30.30.1-0.00.0-0.00.3-0.1-0.00.3-0.40.2-0.10.1-0.1-0.4
Reaction time mean minus median0.50.61.3-0.8-0.6-0.6-0.50.70.7-0.4-0.4-0.40.90.80.70.81.0-0.40.81.10.7-1.0-1.01.0-0.8-0.9
Reaction time mean minus median AUC0.30.40.9-0.7-0.5-0.5-0.40.60.6-0.4-0.4-0.40.80.70.60.70.9-0.40.70.90.6-0.8-0.80.8-0.7-0.8
Reaction time num false alarms1.41.92.21.51.41.41.5-1.4-1.51.51.51.5-1.4-1.4-1.4-1.4-1.31.4-1.4-1.5-1.41.31.3-1.41.11.1
Reaction time num false alarms AUC2.23.13.71.91.81.81.7-1.8-1.91.81.81.8-1.8-1.8-1.7-1.8-1.71.7-1.8-1.9-1.71.71.7-1.81.41.4
Reaction time trials correct on left0.00.00.20.10.10.10.20.0-0.00.30.30.30.1-0.00.0-0.00.3-0.1-0.00.3-0.40.2-0.10.1-0.1-0.4
Reaction time trials on left0.00.10.30.10.20.20.3-0.1-0.10.40.40.40.0-0.1-0.1-0.10.20.0-0.10.2-0.50.30.0-0.0-0.0-0.3
Reaction time mean0.20.30.4-0.6-0.5-0.5-0.50.60.5-0.5-0.5-0.50.50.60.60.60.5-0.40.60.60.7-0.7-0.50.6-0.4-0.5
Reaction time mean AUC0.30.40.6-0.7-0.6-0.6-0.70.70.6-0.7-0.7-0.70.60.70.70.70.6-0.60.70.70.7-0.8-0.60.7-0.5-0.6
Median of all reaction times0.40.50.8-0.8-0.7-0.7-0.70.70.7-0.7-0.7-0.70.60.70.70.70.6-0.60.70.70.9-0.8-0.60.7-0.5-0.5
Reaction time omissions0.71.01.71.01.01.01.0-1.1-1.11.01.01.0-1.0-1.0-1.1-1.0-0.91.3-1.0-0.9-0.91.00.9-1.00.80.9
Reaction time false alarm rate2.53.54.51.91.91.91.8-1.9-2.01.81.81.8-2.0-1.9-1.9-1.9-1.91.9-1.9-2.1-1.61.71.9-2.01.61.8
Reaction time premature initiation rate0.20.30.50.60.50.50.6-0.5-0.50.50.50.5-0.5-0.6-0.5-0.5-0.40.5-0.6-0.5-0.60.70.4-0.50.20.4
Reaction time premature initiations0.20.20.60.50.40.40.6-0.5-0.40.60.60.6-0.3-0.5-0.5-0.5-0.20.4-0.5-0.2-0.80.70.2-0.40.10.1
Std. dev. reaction times0.00.00.1-0.2-0.1-0.1-0.20.20.1-0.2-0.2-0.20.20.20.20.20.3-0.10.20.40.2-0.2-0.20.3-0.2-0.3
Reaction time trials completed0.00.10.30.10.20.20.3-0.1-0.10.40.40.40.0-0.1-0.1-0.10.20.0-0.10.2-0.50.30.0-0.0-0.0-0.3
Reaction time trials AUC0.00.00.3-0.1-0.0-0.00.10.10.10.20.20.20.30.10.10.10.4-0.20.10.5-0.30.1-0.20.2-0.2-0.5
Run reversals in cocaine runway, females0.10.10.2-0.4-0.4-0.4-0.40.20.3-0.3-0.3-0.30.20.20.30.20.1-0.20.2-0.20.5-0.1-0.1-0.1-0.1-0.1
Run reversals in cocaine runway, males4.03.95.32.02.02.02.0-2.1-2.02.02.02.0-1.9-2.1-2.1-2.0-1.82.3-2.1-1.6-2.02.01.8-1.71.71.7
Latency to leave start box in cocaine runway0.10.10.30.20.20.20.0-0.3-0.20.00.00.0-0.3-0.3-0.3-0.3-0.20.6-0.3-0.60.00.40.2-0.60.10.5
Latency to leave start box in cocaine runway, F0.00.00.3-0.2-0.1-0.1-0.0-0.10.1-0.0-0.0-0.00.1-0.0-0.10.10.20.5-0.0-0.10.30.2-0.1-0.2-0.10.1
Latency to leave start box in cocaine runway, M0.20.20.40.50.50.50.1-0.5-0.50.10.10.1-0.6-0.5-0.5-0.5-0.50.5-0.5-0.5-0.30.60.6-0.50.40.7
Std. dev. time between licks in bursts0.70.81.31.01.01.00.7-0.9-0.90.70.70.7-1.0-0.9-0.9-1.0-0.90.5-0.9-1.0-1.11.01.0-1.10.70.7
Total sessions with >9 infusions1.92.12.8-1.5-1.5-1.5-1.71.51.5-1.6-1.6-1.61.41.41.51.41.3-1.61.41.31.5-1.5-1.31.4-1.0-1.1
Short access day 1 total inactive lever presses0.70.81.2-0.9-0.8-0.8-1.10.90.9-1.0-1.0-1.00.90.90.90.90.9-1.10.90.80.8-0.8-0.90.7-0.9-0.8
Short access day 10 total inactive lever presses0.30.30.7-0.5-0.6-0.6-0.60.40.4-0.7-0.7-0.70.60.50.40.50.5-0.30.40.80.5-0.4-0.50.7-0.2-0.3
Short access day 1 total infusions7.88.310.3-2.8-2.8-2.8-3.23.02.9-3.1-3.1-3.12.82.93.02.92.8-3.23.02.92.8-2.8-2.72.8-2.2-2.5
Short access day 10 total infusions3.64.04.7-2.2-2.1-2.1-2.12.12.1-2.0-2.0-2.02.02.02.12.02.0-2.12.01.92.1-1.8-1.91.9-1.8-1.7
Short access total infusions4.75.36.5-2.4-2.3-2.3-2.52.42.3-2.4-2.4-2.42.22.42.42.32.2-2.52.42.12.3-2.1-2.12.1-1.9-1.9
Short access day 1 locomotion3.23.44.7-1.9-1.9-1.9-2.11.91.9-2.0-2.0-2.01.71.81.91.81.8-2.21.81.71.9-1.6-1.61.7-1.6-1.3
Short access day 10 total locomotion4.04.56.0-2.3-2.3-2.3-2.22.12.1-2.2-2.2-2.22.12.12.12.22.1-1.82.12.12.4-2.0-2.02.0-1.7-1.6
Short access total locomotion3.43.54.3-2.0-2.0-2.0-2.11.91.9-2.0-2.0-2.01.81.91.91.91.8-1.91.91.82.0-1.8-1.71.8-1.7-1.4
One hour access (0.3 mA shock)4.35.06.7-2.4-2.3-2.3-2.32.22.3-2.3-2.3-2.32.32.32.22.32.3-1.72.32.32.6-2.1-2.22.2-1.7-1.8
Compulsive drug intake1.41.42.11.21.21.21.3-1.2-1.21.31.31.3-1.1-1.2-1.2-1.1-1.11.4-1.2-0.9-1.21.21.1-0.91.00.9
One hour access (shock baseline)6.77.88.5-2.9-2.9-2.9-2.92.82.8-2.9-2.9-2.92.82.82.82.82.8-2.72.82.82.8-2.8-2.72.7-2.3-2.4
Social response proportion4.64.95.52.22.22.22.3-2.3-2.22.22.22.2-2.2-2.3-2.3-2.3-2.32.3-2.3-2.3-2.22.22.2-2.21.91.9
Social responses0.10.10.3-0.4-0.5-0.5-0.20.30.4-0.2-0.2-0.20.40.30.30.30.5-0.20.30.40.4-0.5-0.50.4-0.3-0.3
Social time2.12.83.61.81.91.91.8-1.7-1.91.81.81.8-1.6-1.7-1.7-1.7-1.51.9-1.7-1.4-1.91.51.6-1.41.51.1
Soleus weight1.54.45.32.02.02.02.1-2.2-2.02.02.02.0-2.1-2.2-2.2-2.1-2.22.3-2.2-2.3-1.72.12.1-2.21.92.1
Bone: stiffness0.30.50.8-0.9-0.9-0.9-0.80.70.9-0.8-0.8-0.80.70.70.70.70.7-0.80.70.50.9-0.9-0.60.6-0.5-0.4
Tibialis anterior weight3.210.812.53.23.23.23.2-3.3-3.33.33.33.3-3.4-3.3-3.3-3.3-3.43.1-3.3-3.5-3.23.53.3-3.43.02.9
Time to tail flick, vehicle, before self-admin5.35.46.8-2.3-2.2-2.2-2.32.32.3-2.3-2.3-2.32.42.42.32.42.4-1.92.42.62.5-2.4-2.32.5-2.0-2.1
Time to tail flick, vehicle, after self-admin5.05.46.7-2.2-2.2-2.2-2.32.42.2-2.4-2.4-2.42.32.42.42.42.3-2.32.42.62.2-2.5-2.22.5-1.9-2.2
Time to tail flick, test, before self-admin1.00.92.3-0.9-0.9-0.9-1.31.10.7-1.1-1.1-1.10.81.01.11.00.8-1.51.00.90.8-0.8-0.70.9-0.6-0.9
Time to tail flick, test, after self-admin2.32.43.2-1.4-1.4-1.4-1.61.61.4-1.8-1.8-1.81.51.61.61.61.6-1.81.61.61.5-1.4-1.41.4-1.4-1.3
Delta time to tail flick, vehicle, before/after SA0.00.00.10.20.10.10.00.0-0.10.00.00.0-0.1-0.00.0-0.1-0.2-0.3-0.0-0.1-0.3-0.10.1-0.00.1-0.1
Delta time to tail flick, test, before/after SA0.10.10.2-0.3-0.3-0.3-0.10.30.4-0.4-0.4-0.40.40.30.30.30.4-0.00.30.30.4-0.3-0.40.3-0.5-0.2
Tibia length0.20.50.70.70.60.60.8-0.7-0.60.80.80.8-0.8-0.8-0.7-0.8-0.70.6-0.8-0.7-0.80.60.6-0.70.40.6
Ambulatory time before self-admin0.30.30.6-0.7-0.7-0.7-0.50.50.7-0.4-0.4-0.40.50.50.60.50.5-0.50.50.30.7-0.5-0.50.4-0.5-0.3
Ambulatory time after self-admin0.40.50.9-0.8-0.8-0.8-1.00.70.6-0.8-0.8-0.80.60.70.70.70.7-0.80.70.50.8-0.5-0.60.5-0.6-0.5
Bone: tissue strength0.00.00.0-0.10.00.00.2-0.1-0.00.10.10.1-0.0-0.1-0.1-0.0-0.00.2-0.10.00.00.10.1-0.00.00.0
Total heroin consumption0.91.02.10.80.80.81.1-1.1-0.81.01.01.0-1.0-1.0-1.1-1.0-1.01.4-1.1-1.0-0.60.91.0-0.81.21.1
Bone: trabecular number0.40.61.0-0.7-0.8-0.8-0.90.80.9-0.9-0.9-0.90.70.80.80.80.7-1.00.80.70.6-0.7-0.70.7-0.8-0.7
Bone: trabecular spacing0.30.40.9-0.6-0.6-0.6-0.40.60.5-0.4-0.4-0.40.70.60.60.70.8-0.30.60.90.7-0.9-0.90.9-0.7-0.7
Bone: trabecular thickness0.20.20.4-0.5-0.5-0.5-0.40.50.6-0.5-0.5-0.50.40.40.50.40.4-0.50.40.40.4-0.3-0.40.4-0.4-0.4
Bone: trabecular tissue density1.01.42.01.01.11.11.1-1.3-1.11.11.11.1-1.1-1.2-1.2-1.2-1.21.4-1.2-1.3-0.91.01.2-1.21.41.2
Water consumed over 24 hours0.10.10.3-0.4-0.4-0.4-0.30.30.3-0.4-0.4-0.40.20.30.30.30.2-0.50.30.10.3-0.3-0.30.2-0.3-0.1
Number of responses in last shaping day1.31.32.1-1.1-1.1-1.1-1.21.21.2-1.2-1.2-1.21.11.21.21.21.1-1.31.21.51.2-1.0-1.11.4-0.7-1.0