Hub : Genes

Apba3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	isoform ratio	NM_031781.1	0.12	0.09	5.8e-03	0.02	0.03	0.02	0.01	9.1e-02	4.7e-02	1.2e-01	1.3e-01
2	NAcc	gene expression	Apba3	0.03	0.02	2.0e-04	0.02	0.03	0.03	0.03	2.1e-03	1.9e-04	2.4e-04	5.4e-04
3	Brain	gene expression	Apba3	0.04	0.03	2.1e-03	0.02	0.02	0.02	0.02	4.5e-03	8.3e-03	6.7e-03	1.0e-02
4	PL	gene expression	Apba3	0.04	0.03	1.9e-05	0.04	0.04	0.04	0.04	1.0e-05	2.2e-05	1.2e-05	3.2e-05
5	Liver	isoform ratio	XM_006241020.3	0.2	0.1	0.0e+00	0.23	0.23	0.23	0.23	8.9e-26	2.4e-25	3.2e-25	1.0e-25
6	Liver	isoform ratio	NM_031781.1	0.37	0.17	0.0e+00	0.31	0.32	0.31	0.32	2.5e-35	1.9e-36	2.0e-35	7.8e-36
7	Liver	gene expression	Apba3	0.05	0.04	2.9e-07	0.06	0.06	0.05	0.06	3.3e-07	5.2e-07	4.8e-06	6.0e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	0.1	0.2	0.4	0.1	0.1	-0.6	-0.6	-0.5	-0.5	0.6
Area under the delay curve	2.5	2.7	3.3	-1.5	1.6	-1.6	-1.8	-1.6	-1.7	1.6
BMI with tail	6.6	21.3	22.8	-4.8	4.7	-4.6	-4.5	-4.6	-4.5	4.6
BMI without tail	2.0	4.2	5.2	-2.3	2.2	-2.0	-2.0	-2.0	-1.9	2.0
Body weight	1.2	5.0	5.2	-2.3	2.3	-2.2	-2.2	-2.2	-2.2	2.2
Weight adjusted by age	0.1	0.2	0.4	-0.6	0.5	-0.3	-0.2	-0.4	-0.2	0.4
Bone surface	0.1	0.2	0.5	0.7	-0.4	-0.3	-0.3	-0.3	-0.2	0.3
Bone volume	0.1	0.2	0.5	0.7	-0.4	-0.3	-0.3	-0.3	-0.2	0.3
Breakpoint value in progressive ratio session	6.2	6.8	7.4	2.5	-2.6	2.7	2.7	2.5	2.7	-2.6
Number of licking bursts	0.0	0.0	0.1	-0.2	0.1	0.0	0.2	-0.0	0.1	-0.2
Context. condit. distance diff. score	0.3	0.4	0.4	-0.6	0.6	-0.6	-0.6	-0.7	-0.6	0.5
Locomotion velocity, session 1	0.4	0.4	0.7	0.8	-0.8	0.6	0.4	0.6	0.5	-0.5
Locomotion distance, session 1	0.0	0.0	0.1	0.3	-0.2	-0.1	-0.2	-0.0	-0.1	0.1
Locomotion velocity, session 2	2.6	3.0	4.3	2.1	-1.9	1.6	1.5	1.7	1.6	-1.6
Locomotion distance, session 2	0.9	1.2	2.2	1.5	-1.3	0.9	0.9	1.0	1.0	-1.0
Locomotion velocity, session 3	6.4	7.5	7.7	2.8	-2.8	2.8	2.7	2.8	2.7	-2.7
Locomotion distance, session 3	0.0	0.0	0.0	0.0	-0.1	0.2	0.0	0.2	0.1	-0.1
Stereotopy head waving bouts, day 3	4.4	5.2	6.0	2.4	-2.4	2.2	2.2	2.2	2.2	-2.2
Stereotopy head waving duration, day 3	5.4	6.5	7.1	2.7	-2.6	2.5	2.5	2.5	2.5	-2.5
Locomotion velocity, session 7	0.7	0.8	1.0	1.0	-0.9	0.8	0.8	0.9	0.8	-0.8
Locomotion distance, session 7	0.0	0.0	0.1	-0.3	0.2	-0.0	-0.1	-0.0	-0.1	0.1
Stereotopy head waving bouts, day 7	0.0	0.1	0.1	0.1	0.0	-0.2	-0.3	-0.3	-0.3	0.3
Stereotopy head waving duration, day 7	0.0	0.1	0.2	0.5	-0.4	0.1	0.1	0.0	0.1	-0.1
Locomotion velocity, session 8	0.2	0.2	0.6	0.8	-0.6	0.3	0.3	0.2	0.3	-0.3
Locomotion distance, session 8	0.0	0.1	0.1	0.3	-0.3	0.1	0.2	0.2	0.2	-0.2
Degree of sensitization distance	0.4	0.4	0.5	-0.6	0.6	-0.7	-0.6	-0.7	-0.6	0.6
Degree of sensitization stereotypy	2.2	2.5	2.7	-1.4	1.5	-1.6	-1.6	-1.6	-1.6	1.6
Conditioned locomotion	1.2	1.4	2.2	-1.5	1.4	-1.1	-1.0	-1.1	-1.1	1.1
Cocaine response after cond. corrected	4.3	4.8	6.3	-2.5	2.4	-2.1	-2.1	-2.1	-2.1	2.0
Cocaine response after cond. not corrected	4.6	5.0	6.7	-2.6	2.5	-2.1	-2.1	-2.1	-2.1	2.1
Cocaine response before conditioning	0.4	0.5	0.6	0.8	-0.8	0.7	0.7	0.7	0.7	-0.6
Saline control response	0.0	0.0	0.1	-0.3	0.2	-0.2	-0.1	-0.1	-0.2	0.2
Bone: connectivity density	0.4	0.6	0.9	-0.4	0.5	-0.9	-1.0	-0.8	-0.9	1.0
Bone: cortical apparent density	1.0	1.3	1.9	-1.1	1.1	-1.2	-1.0	-1.4	-1.1	1.0
Bone: cortical area	0.8	1.2	1.7	-0.8	0.9	-1.2	-1.1	-1.3	-1.1	1.1
Bone: cortical porosity	0.4	0.5	0.7	0.8	-0.8	0.6	0.6	0.6	0.6	-0.6
Bone: cortical porosity	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.1	-0.2	-0.1	0.1
Bone: cortical thickness	1.3	2.2	2.6	-1.3	1.4	-1.6	-1.5	-1.6	-1.5	1.5
Bone: cortical thickness	0.0	0.0	0.1	0.0	-0.1	0.2	0.3	0.3	0.2	-0.3
Bone: cortical tissue density	0.7	0.9	1.4	-0.9	0.9	-0.9	-0.8	-1.2	-0.9	0.8
Condit. Reinf. active minus inactive responses	4.2	4.7	5.0	2.2	-2.2	2.1	2.1	2.2	2.1	-2.2
Condit. Reinf. active-inactive response ratio	2.5	2.7	2.8	1.5	-1.6	1.7	1.6	1.7	1.6	-1.7
Condit. Reinf. active responses	3.2	3.9	4.8	2.2	-2.1	1.9	1.9	1.9	1.9	-1.9
Condit. Reinf. inactive responses	0.5	0.6	1.0	1.0	-0.9	0.6	0.6	0.7	0.7	-0.7
Incentive salience index mean	1.9	2.3	2.9	1.7	-1.6	1.4	1.4	1.4	1.4	-1.5
Condit. Reinf. lever presses	0.1	0.1	0.1	0.2	-0.1	-0.3	-0.4	-0.3	-0.3	0.2
Condit. Reinf. active minus inactive responses	2.8	3.5	3.8	1.7	-1.8	1.9	1.9	1.9	1.9	-1.9
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	0.2	-0.4	0.7	0.6	0.7	0.6	-0.7
Condit. Reinf. active responses	2.5	3.5	3.6	1.9	-1.9	1.8	1.8	1.9	1.9	-1.9
Condit. Reinf. inactive responses	1.1	1.4	1.8	1.3	-1.3	1.0	1.1	1.1	1.1	-1.1
Condit. Reinf. lever presses	2.8	3.8	4.1	1.8	-1.9	2.0	2.0	2.0	2.0	-2.0
Condit. Reinf. lever reinforcers received	2.0	2.8	3.1	1.6	-1.7	1.7	1.7	1.8	1.7	-1.7
Conditioned reinforcement - actives	2.9	2.9	3.0	1.7	-1.7	1.7	1.7	1.6	1.7	-1.7
Conditioned reinforcement - inactives	0.4	0.5	0.7	-0.8	0.8	-0.6	-0.5	-0.6	-0.8	0.6
Conditioned locomotion	8.6	10.4	10.7	3.3	-3.3	3.2	3.1	3.2	3.2	-3.2
Patch foraging indifference point 0 sec	0.2	0.3	0.4	-0.5	0.5	-0.6	-0.5	-0.6	-0.6	0.5
Patch foraging indifference point AUC	1.2	1.4	1.6	1.1	-1.2	1.2	1.1	1.1	1.3	-1.2
Delay disc. indifference point, 0s delay	8.4	9.2	10.0	-2.8	2.9	-3.1	-3.1	-3.1	-3.2	3.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.4	0.4	-0.4	-0.6	-0.4	-0.4	0.4
Delay disc. indifference point, 2s delay	6.4	7.1	7.5	-2.5	2.6	-2.7	-2.7	-2.7	-2.7	2.7
Delay disc. indifference point, 24s delay	0.6	0.6	1.0	-0.8	0.7	-0.7	-1.0	-0.7	-0.7	0.8
Delay disc. indifference point, 4s delay	1.4	1.5	2.0	-1.0	1.1	-1.3	-1.4	-1.2	-1.3	1.3
Delay disc. indifference point, 8s delay	1.0	1.1	1.2	-1.1	1.1	-1.0	-1.1	-0.9	-1.0	1.0
Indifference point function ln k	0.2	0.3	0.4	-0.6	0.6	-0.6	-0.5	-0.6	-0.6	0.5
Indifference point function log k	0.2	0.3	0.4	-0.6	0.6	-0.6	-0.5	-0.6	-0.6	0.5
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	-0.4	0.5	-0.5	-0.4	-0.5	-0.5	0.4
Patch foraging total patch changes 12 sec	0.2	0.2	0.4	-0.7	0.6	-0.5	-0.4	-0.4	-0.3	0.4
Patch foraging total patch changes 18 sec	1.1	1.4	1.6	1.2	-1.2	1.2	1.3	1.1	1.2	-1.2
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	0.3	-0.3	0.2	0.3	0.4	0.4	-0.3
Patch foraging total patch changes 6 sec	0.2	0.2	0.3	0.5	-0.5	0.4	0.6	0.4	0.4	-0.6
Patch foraging time to switch 0 sec	2.0	3.1	3.5	-1.5	1.6	-1.9	-1.8	-1.7	-1.8	1.9
Patch foraging water rate 0 sec	0.1	0.2	0.4	0.2	-0.3	0.5	0.6	0.5	0.5	-0.7
Patch foraging water rate 12 sec	0.6	0.8	1.5	-1.2	1.1	-0.8	-0.8	-0.9	-0.8	0.7
Patch foraging water rate 18 sec	0.5	0.6	1.1	0.2	-0.4	0.8	1.0	0.8	0.9	-1.0
Patch foraging water rate 24 sec	0.1	0.1	0.4	-0.7	0.5	0.1	0.1	0.1	-0.1	-0.2
Patch foraging water rate 6 sec	0.7	1.0	1.5	0.6	-0.8	1.1	1.1	1.2	1.0	-1.1
Seeking ratio, delayed vs. immediate footshock	4.7	5.4	6.3	2.5	-2.5	2.3	2.2	2.3	2.3	-2.2
Distance traveled before self-admin	0.3	0.3	0.5	-0.5	0.5	-0.6	-0.7	-0.6	-0.6	0.5
Distance traveled after self-admin	0.8	0.9	1.1	1.0	-1.0	0.9	0.8	1.0	0.9	-1.0
Extensor digitorum longus weight	4.3	16.8	19.6	-4.4	4.3	-3.9	-4.1	-4.0	-4.0	3.9
Bone: elastic displacement	0.3	0.3	0.4	0.6	-0.6	0.6	0.5	0.6	0.5	-0.5
Bone: elastic work	0.2	0.3	0.4	-0.4	0.5	-0.6	-0.6	-0.6	-0.6	0.6
Bone: endosteal estimation	0.3	0.6	0.8	-0.6	0.7	-0.8	-0.8	-0.9	-0.8	0.8
Bone: endosteal perimeter	0.1	0.3	0.6	0.8	-0.7	0.4	0.4	0.3	0.4	-0.4
Epididymis fat weight	0.2	0.6	0.6	0.6	-0.6	0.8	0.8	0.8	0.8	-0.8
Delta time in closed arm before/after self-admin	0.2	0.2	0.7	-0.8	0.6	-0.3	-0.3	-0.2	-0.2	0.3
Delta time in open arm before/after self-admin	1.5	1.5	1.7	-1.1	1.2	-1.2	-1.3	-1.3	-1.3	1.2
Diff in mean of infusions in LGA sessions	1.7	1.9	2.0	1.4	-1.4	1.4	1.4	1.3	1.4	-1.4
Delay discount exponential model param	2.3	2.4	3.0	1.5	-1.5	1.5	1.7	1.5	1.6	-1.5
Extinction: sum of active levers before priming	1.8	1.8	2.3	1.1	-1.2	1.4	1.5	1.3	1.4	-1.4
Active lever presses in extinction session 6	3.4	3.3	3.4	1.9	-1.8	1.8	1.8	1.7	1.8	-1.8
Bone: final force	1.5	2.5	2.9	-1.3	1.4	-1.7	-1.6	-1.7	-1.6	1.6
Bone: final moment	1.2	2.0	2.3	-1.2	1.3	-1.5	-1.4	-1.5	-1.4	1.4
Food consumed during 24 hour testing period	0.5	0.6	0.6	-0.8	0.8	-0.8	-0.7	-0.8	-0.7	0.7
Glucose	1.2	1.8	2.0	-1.4	1.4	-1.3	-1.4	-1.2	-1.3	1.3
Heart weight	0.5	0.7	0.9	0.7	-0.7	0.9	0.8	0.9	0.9	-0.8
Delay discount hyperbolic model param	3.2	3.4	3.9	1.7	-1.8	1.8	2.0	1.8	1.9	-1.9
Intermittent access intake day 1-15 change	7.8	7.7	8.1	2.7	-2.7	2.8	2.8	2.8	2.7	-2.8
Intermittent access intake escalation	8.1	8.0	8.7	2.6	-2.7	3.0	2.9	2.9	2.8	-2.9
Intermittent access intake escalation 2	9.7	9.6	10.2	2.9	-3.0	3.2	3.2	3.2	3.1	-3.2
Intermitt. access day 1 inactive lever presses	0.6	0.6	0.9	0.6	-0.7	0.9	0.7	0.9	0.8	-0.9
Intermitt. access day 15 inactive lever presses	0.5	0.6	0.7	0.7	-0.7	0.8	0.8	0.7	0.7	-0.8
Intermitt. access escalation Index	0.4	0.4	0.6	-0.4	0.4	-0.7	-0.7	-0.8	-0.6	0.7
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.3	0.3	-0.2	-0.2	-0.4	-0.3	0.3
Intermittent access day 15 total infusions	2.3	2.6	3.1	1.5	-1.5	1.7	1.8	1.5	1.6	-1.7
Intermittent access terminal intake (last 3 days)	1.3	1.5	1.7	1.2	-1.2	1.3	1.3	1.0	1.2	-1.2
Intermittent access total infusions	0.2	0.3	0.5	0.5	-0.5	0.6	0.7	0.4	0.5	-0.6
Intermittent access day 1 locomotion	0.3	0.4	0.5	0.5	-0.5	0.7	0.7	0.5	0.5	-0.6
Intermittent access day 15 total locomotion	4.0	4.3	4.9	2.0	-2.0	2.2	2.1	2.0	2.0	-2.2
Intermittent access total locomotion	1.2	1.3	1.5	1.1	-1.1	1.2	1.2	1.0	1.1	-1.2
Intermittent access standard deviation	3.9	4.1	4.5	1.9	-2.0	2.1	2.1	2.0	2.0	-2.1
Left kidney weight	0.0	0.0	0.1	0.3	-0.3	0.0	0.0	0.0	0.2	-0.0
Right kidney weight	1.5	4.1	4.5	2.1	-2.1	1.9	2.0	2.0	2.1	-2.0
Cocaine induced anxiety	0.5	0.6	0.9	1.0	-0.9	0.6	0.6	0.7	0.8	-0.6
Post-drug Anxiety	0.2	0.2	0.5	0.7	-0.6	0.3	0.3	0.4	0.5	-0.3
Baseline Anxiety	0.0	0.0	0.1	0.1	-0.2	0.2	0.3	0.2	0.3	-0.3
Tail length	3.5	10.6	11.0	3.2	-3.2	3.3	3.2	3.3	3.3	-3.3
Length with tail	1.9	6.9	7.6	2.8	-2.7	2.6	2.6	2.6	2.5	-2.6
Length without tail	0.0	0.0	0.1	0.4	-0.2	0.0	0.0	0.0	-0.1	0.0
Times rat made contact with spout	0.1	0.1	0.2	-0.5	0.4	-0.3	-0.3	-0.2	-0.3	0.3
Lifetime Intake	0.1	0.1	0.2	0.3	-0.3	0.4	0.5	0.1	0.3	-0.3
Liver weight, left	2.4	3.8	4.5	-2.1	2.1	-1.8	-1.9	-1.9	-1.9	1.9
Liver weight, right	1.8	3.1	3.2	-1.8	1.8	-1.7	-1.7	-1.7	-1.8	1.8
Locomotor activity	2.9	4.7	6.1	2.5	-2.4	2.0	2.1	2.0	2.0	-2.1
Locomotor testing distance	1.9	3.1	3.8	2.0	-1.9	1.7	1.8	1.6	1.7	-1.7
Locomotor testing rearing	0.0	0.1	0.1	0.2	-0.2	0.3	0.3	0.2	0.3	-0.3
Locomotion in novel chamber	0.6	0.7	0.9	0.7	-0.8	0.9	0.8	0.9	0.9	-0.8
Locomotion in novel chamber post-restriction	0.8	0.9	1.0	1.0	-1.0	0.9	1.0	1.0	1.0	-1.0
Fecal boli incidents, locomotor time 1	1.5	1.7	2.3	-1.5	1.4	-1.2	-1.1	-1.3	-1.2	1.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.6	-0.5	0.3	0.4	0.3	0.3	-0.3
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.6	-0.5	0.5	-0.7	-0.7	-0.7	-0.7	0.6
Bouts of movement, locomotor time 1	0.2	0.2	0.3	0.4	-0.4	0.5	0.5	0.4	0.4	-0.5
Total resting periods, locomotor time 1	0.2	0.3	0.3	0.5	-0.5	0.5	0.5	0.4	0.5	-0.6
Rest time, locomotor task time 1	0.2	0.2	0.3	0.5	-0.4	0.4	0.5	0.3	0.4	-0.5
Distance moved, locomotor task time 1	0.6	0.6	0.9	-0.6	0.7	-0.8	-0.9	-0.8	-0.9	0.9
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.1	-0.1	-0.2	0.2
Time >=10cm from walls, locomotor time 2	0.9	1.0	1.2	-1.1	1.1	-0.9	-1.0	-1.0	-1.0	0.8
Bouts of movement, locomotor time 2	0.2	0.2	0.5	0.7	-0.6	0.4	0.3	0.4	0.4	-0.4
Total resting periods, locomotor time 2	0.2	0.2	0.4	0.6	-0.6	0.3	0.2	0.4	0.4	-0.4
Rest time, locomotor task time 2	0.4	0.4	0.6	0.8	-0.8	0.6	0.5	0.5	0.6	-0.7
Distance moved, locomotor task time 2	0.6	0.7	1.0	-1.0	0.9	-0.8	-0.8	-0.8	-0.8	0.8
Vertical activity count, locomotor time 2	0.4	0.5	0.9	-0.9	0.8	-0.6	-0.5	-0.7	-0.6	0.5
Light reinforcement 1	5.6	10.1	11.2	3.3	-3.3	3.1	3.1	3.2	3.1	-3.1
Light reinforcement 2	1.7	2.3	2.6	1.6	-1.6	1.5	1.5	1.4	1.4	-1.5
Bone: marrow area	0.3	0.6	0.8	-0.6	0.7	-0.8	-0.8	-0.9	-0.8	0.8
Bone: maximum diameter	0.4	0.7	1.4	1.2	-1.0	0.7	0.8	0.6	0.8	-0.8
Bone: maximum force	1.5	2.6	3.1	-1.4	1.5	-1.7	-1.6	-1.8	-1.6	1.6
Bone: maximum moment	1.3	2.2	2.7	-1.3	1.4	-1.6	-1.5	-1.7	-1.5	1.5
Mean time between licks in bursts	4.5	6.3	6.5	2.4	-2.5	2.5	2.6	2.5	2.5	-2.6
Mean num. licks in bursts	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.3	-0.1	-0.2	0.3
Cd content in liver	0.2	0.2	0.3	-0.4	0.5	-0.5	-0.5	-0.5	-0.5	0.5
Co content in liver	0.7	0.8	0.9	0.8	-0.9	0.9	0.9	0.9	0.9	-0.9
Cu content in liver	0.2	0.2	0.3	-0.2	0.3	-0.5	-0.6	-0.5	-0.5	0.5
Fe content in liver	0.0	0.0	0.1	0.1	-0.1	0.2	0.3	0.2	0.2	-0.2
K content in liver	0.0	0.0	0.1	0.1	-0.0	-0.2	-0.3	-0.2	-0.2	0.2
Mg content in liver	0.1	0.1	0.1	0.1	0.0	-0.2	-0.4	-0.2	-0.2	0.2
Mn content in liver	0.4	0.5	1.3	1.1	-0.9	0.5	0.5	0.5	0.5	-0.5
Na content in liver	1.3	1.4	1.5	-1.0	1.1	-1.2	-1.2	-1.2	-1.2	1.2
Rb content in liver	0.6	0.7	0.9	-0.6	0.7	-0.9	-0.9	-0.9	-0.9	0.9
Se content in liver	0.1	0.2	0.2	0.5	-0.5	0.4	0.4	0.4	0.4	-0.4
Sr content in liver	0.1	0.0	0.1	-0.0	-0.1	0.3	0.3	0.3	0.2	-0.3
Zn content in liver	2.8	3.1	3.5	1.4	-1.6	1.9	1.8	1.9	1.8	-1.9
Bone: minimum diameter	0.0	0.1	0.2	-0.0	0.1	-0.3	-0.3	-0.4	-0.3	0.3
Time in familiar zone, hab. session 1	2.4	2.3	2.5	1.4	-1.5	1.5	1.6	1.6	1.5	-1.5
Time in novel zone, hab. session 1	1.3	1.3	1.5	-0.9	1.0	-1.2	-1.2	-1.2	-1.2	1.1
Total zone transitions, hab. session 1	0.5	0.8	1.3	1.1	-1.0	0.7	0.7	0.8	0.8	-0.8
Total locomotion distance, hab. session 1	0.5	0.7	1.6	1.3	-1.1	0.6	0.6	0.8	0.7	-0.6
Locomotion velocity, hab. session 1	0.9	1.3	2.2	1.5	-1.3	1.0	1.0	1.1	1.0	-1.0
Time in familiar zone, hab. session 2	7.3	7.5	8.0	2.6	-2.7	2.8	2.8	2.8	2.8	-2.7
Time in novel zone, hab. session 2	5.5	5.5	5.9	-2.1	2.2	-2.4	-2.4	-2.4	-2.4	2.4
Total zone transitions, hab. session 2	0.4	0.5	0.8	-0.4	0.5	-0.9	-0.8	-0.7	-0.8	0.8
Total locomotion distance, hab. session 2	0.5	0.7	1.1	1.1	-1.0	0.7	0.7	0.9	0.8	-0.7
Locomotion velocity, hab. session 2	0.4	0.6	1.1	1.0	-0.9	0.6	0.6	0.7	0.7	-0.6
Novel to familiar place preference ratio	4.8	4.9	5.5	-2.0	2.1	-2.2	-2.3	-2.3	-2.3	2.3
Novelty place preference	2.9	3.0	3.4	-1.5	1.6	-1.7	-1.9	-1.8	-1.8	1.8
Time in novel zone, NPP test	3.3	3.4	3.9	-1.6	1.7	-1.8	-2.0	-1.9	-1.9	1.9
Total zone transitions, NPP test	0.0	0.1	0.1	-0.1	0.1	-0.4	-0.3	-0.2	-0.3	0.3
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.1	0.2	-0.5	-0.5	-0.3	-0.4	0.5
Locomotion velocity, NPP test	0.0	0.0	0.0	0.2	-0.1	-0.2	-0.2	-0.0	-0.1	0.2
Intraocular pressure	0.1	0.2	0.3	0.1	-0.2	0.5	0.5	0.5	0.6	-0.4
Delta distance traveled before/after self-admin	1.6	1.7	1.8	1.4	-1.3	1.3	1.3	1.3	1.3	-1.3
Delta ambulatory time before/after self-admin	1.6	1.8	2.1	1.4	-1.4	1.3	1.3	1.3	1.3	-1.3
Parametrial fat weight	0.5	1.0	1.2	1.0	-1.0	1.1	1.1	1.0	1.0	-1.0
Pavlov. Cond. lever latency	0.1	0.1	0.1	0.0	-0.1	0.3	0.4	0.3	0.3	-0.4
Pavlov. Cond. magazine entry latency	3.0	3.8	4.1	1.9	-2.0	1.9	2.0	1.9	2.0	-2.0
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.2	-0.2	0.2	0.2	0.3	0.2	-0.2
Pavlov. Cond. index score	0.2	0.3	0.5	0.7	-0.6	0.5	0.5	0.5	0.5	-0.5
Pavlov. Cond. latency score	0.2	0.2	0.5	0.7	-0.6	0.4	0.4	0.4	0.4	-0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.2	-0.1	-0.1	0.2
Pavlov. Cond. magazine entry number	0.6	0.8	0.8	-0.9	0.9	-0.8	-0.9	-0.8	-0.9	0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	0.3	-0.4	0.4	0.6	0.5	0.5	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.0	1.0	-0.9	0.8	0.8	0.8	0.8	-0.8
Pavlov. Cond. response bias	1.0	1.3	1.3	1.2	-1.1	1.1	1.1	1.1	1.1	-1.1
Pavlov. Cond. lever latency	0.9	1.2	1.3	-1.2	1.1	-1.1	-1.1	-1.1	-1.1	1.0
Pavlov. Cond. magazine entry latency	0.5	0.6	0.7	0.9	-0.8	0.8	0.7	0.6	0.7	-0.7
Pavlov. Cond. change in total contacts	1.0	1.3	1.5	1.1	-1.2	1.2	1.1	1.2	1.2	-1.1
Pavlov. Cond. index score	1.0	1.3	1.4	1.2	-1.2	1.2	1.1	1.1	1.1	-1.1
Pavlov. Cond. latency score	0.9	1.1	1.3	1.1	-1.1	1.1	1.0	1.0	1.0	-1.0
Pavlov. Cond. lever contacts	0.9	1.3	1.4	1.1	-1.1	1.2	1.1	1.2	1.1	-1.1
Pavlov. Cond. magazine entry number	0.8	1.0	1.2	-1.1	1.1	-1.0	-0.9	-0.9	-1.0	1.0
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.5	-0.7	0.7	-0.7	-0.4	-0.6	-0.5	0.4
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	1.4	1.2	-1.2	1.2	1.1	1.1	1.1	-1.1
Pavlov. Cond. response bias	2.2	2.9	3.2	1.7	-1.7	1.8	1.7	1.7	1.7	-1.7
Time in closed arm before self-admin	1.2	1.3	1.6	-0.9	1.0	-1.2	-1.2	-1.2	-1.3	1.3
Time in closed arm after self-admin	0.0	0.0	0.1	0.1	-0.1	0.0	0.1	0.3	0.2	-0.1
Time in open arm before self-admin	1.3	1.4	1.6	1.1	-1.2	1.2	1.1	1.3	1.2	-1.2
Time in open arm after self-admin	0.7	0.8	0.9	-0.9	0.9	-0.8	-0.9	-0.9	-1.0	0.8
Bone: periosteal estimation	0.5	1.1	1.6	-0.7	0.8	-1.2	-1.1	-1.3	-1.1	1.1
Bone: periosteal perimeter	0.0	0.0	0.1	0.4	-0.2	-0.1	-0.0	-0.2	-0.1	0.0
Bone: post-yield work	0.6	0.9	1.1	-0.9	0.9	-1.0	-0.8	-1.1	-0.9	0.8
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	-0.4	0.3	-0.2	-0.1	-0.3	-0.3	0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.5	0.4	-0.3	-0.2	-0.5	-0.4	0.3
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	0.0	0.0	-0.1
Progressive ratio test 2 active lever presses	0.4	0.4	0.5	0.5	-0.5	0.7	0.7	0.6	0.7	-0.7
Progressive ratio test 2 breakpoint	0.4	0.4	0.5	0.6	-0.6	0.7	0.7	0.6	0.7	-0.7
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	0.3	-0.3	0.3	0.3	0.1	0.2	-0.2
Incentive Sensitization - Responses	0.5	0.5	0.7	0.6	-0.7	0.8	0.7	0.7	0.8	-0.8
Incentive Sensitization - Breakpoint	0.6	0.6	0.7	0.7	-0.7	0.8	0.7	0.8	0.9	-0.8
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.0	-0.0	0.1	0.1	-0.0	0.0	-0.1
Progressive ratio	0.1	0.1	0.3	-0.5	0.4	-0.2	-0.4	-0.3	-0.3	0.4
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.3	-0.3	0.2	0.3	0.5	0.4	-0.3
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.4	-0.3	0.1	0.3	0.3	0.2	-0.3
Retroperitoneal fat weight	0.4	1.2	1.5	-1.2	1.2	-1.1	-1.0	-1.2	-1.2	1.0
Reaction time number correct	0.3	0.4	0.8	-0.9	0.8	-0.6	-0.5	-0.5	-0.5	0.5
Reaction time mean minus median	0.8	1.1	1.2	1.1	-1.1	1.0	1.0	0.9	1.1	-1.1
Reaction time mean minus median AUC	0.0	0.0	0.2	0.2	-0.1	-0.1	-0.2	-0.4	-0.1	0.2
Reaction time num false alarms	0.0	0.0	0.0	-0.2	0.2	-0.1	-0.1	-0.0	-0.0	0.0
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.3	0.3	-0.1	-0.1	-0.1	-0.0	0.1
Reaction time trials correct on left	0.3	0.4	0.8	-0.9	0.8	-0.6	-0.5	-0.5	-0.5	0.5
Reaction time trials on left	0.3	0.4	0.8	-0.9	0.8	-0.6	-0.5	-0.6	-0.5	0.5
Reaction time mean	0.0	0.1	0.2	0.0	0.0	-0.3	-0.2	-0.4	-0.2	0.2
Reaction time mean AUC	0.1	0.1	0.3	-0.0	0.1	-0.4	-0.3	-0.5	-0.3	0.3
Median of all reaction times	0.4	0.6	0.9	-0.5	0.6	-0.8	-0.8	-1.0	-0.8	0.7
Reaction time omissions	0.2	0.3	0.4	0.6	-0.6	0.5	0.5	0.4	0.5	-0.6
Reaction time false alarm rate	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1	-0.1	-0.0	0.1
Reaction time premature initiation rate	1.3	1.7	2.1	1.1	-1.2	1.3	1.4	1.4	1.3	-1.4
Reaction time premature initiations	0.8	1.2	1.6	0.7	-0.9	1.1	1.3	1.2	1.1	-1.3
Std. dev. reaction times	0.2	0.3	0.4	0.7	-0.6	0.5	0.5	0.2	0.6	-0.5
Reaction time trials completed	0.3	0.4	0.8	-0.9	0.8	-0.6	-0.5	-0.6	-0.5	0.5
Reaction time trials AUC	0.2	0.3	0.8	-0.9	0.7	-0.5	-0.4	-0.5	-0.4	0.4
Run reversals in cocaine runway, females	0.5	0.4	0.6	0.8	-0.8	0.5	0.5	0.8	0.7	-0.5
Run reversals in cocaine runway, males	1.1	1.1	1.3	1.1	-1.1	0.9	1.0	1.1	1.1	-1.0
Latency to leave start box in cocaine runway	0.7	0.8	1.3	1.2	-1.0	0.8	0.8	0.6	0.8	-0.9
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.2	-0.0	-0.4	-0.2	-0.5	-0.3	0.2
Latency to leave start box in cocaine runway, M	3.6	3.5	4.1	1.7	-1.8	2.0	1.9	1.8	1.9	-1.9
Std. dev. time between licks in bursts	0.6	0.7	1.1	1.1	-1.0	0.7	0.8	0.7	0.8	-0.8
Total sessions with >9 infusions	0.0	0.0	0.0	0.1	-0.1	-0.1	0.0	-0.2	0.0	0.1
Short access day 1 total inactive lever presses	0.0	0.1	0.1	0.2	-0.2	0.2	0.3	0.2	0.2	-0.2
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.2	-0.3	0.4	0.3	0.4	0.3	-0.4
Short access day 1 total infusions	0.1	0.1	0.1	0.4	-0.3	0.2	0.3	-0.0	0.2	-0.1
Short access day 10 total infusions	0.0	0.0	0.1	0.1	-0.1	0.2	0.3	-0.1	0.2	-0.2
Short access total infusions	0.0	0.0	0.1	0.1	-0.0	0.0	0.1	-0.2	0.1	0.0
Short access day 1 locomotion	0.7	0.8	1.1	1.0	-1.0	0.9	1.0	0.7	0.8	-0.9
Short access day 10 total locomotion	4.9	5.5	6.1	2.3	-2.3	2.4	2.5	2.3	2.3	-2.4
Short access total locomotion	1.0	1.0	1.3	1.1	-1.0	1.1	1.1	0.8	1.0	-1.0
One hour access (0.3 mA shock)	0.2	0.2	0.3	-0.5	0.5	-0.4	-0.3	-0.5	-0.5	0.4
Compulsive drug intake	1.2	1.2	1.4	-1.0	1.0	-1.2	-1.2	-0.9	-1.2	1.2
One hour access (shock baseline)	0.1	0.1	0.2	0.2	-0.2	0.4	0.5	0.2	0.3	-0.4
Social response proportion	0.5	0.5	0.7	0.8	-0.8	0.7	0.6	0.8	0.7	-0.6
Social responses	7.0	9.0	10.5	3.2	-3.2	3.0	2.8	3.0	3.0	-2.8
Social time	0.7	0.9	1.0	-1.0	1.0	-0.9	-0.9	-0.9	-0.9	0.9
Soleus weight	9.4	27.5	28.4	-5.3	5.3	-5.2	-5.2	-5.2	-5.2	5.2
Bone: stiffness	3.5	5.6	6.1	-2.2	2.3	-2.5	-2.3	-2.5	-2.4	2.3
Tibialis anterior weight	1.1	3.7	4.4	-1.9	1.9	-1.8	-2.1	-1.8	-2.0	1.9
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.7	0.8	-0.7	0.5	0.4	0.5	0.6	-0.4
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	0.2	-0.3	0.4	0.5	0.6	0.5	-0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.4	-0.3	0.1	0.2	0.1	0.3	-0.0
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.4	-0.4	0.3	0.3	0.2	0.4	-0.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.6	-0.8	0.7	-0.4	-0.3	-0.3	-0.4	0.4
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	0.3	-0.3	0.5	0.4	0.5	0.4	-0.5
Tibia length	1.0	2.9	3.1	1.6	-1.7	1.8	1.7	1.7	1.7	-1.7
Ambulatory time before self-admin	0.2	0.2	0.4	-0.5	0.5	-0.4	-0.6	-0.5	-0.5	0.4
Ambulatory time after self-admin	0.5	0.5	0.6	0.8	-0.8	0.7	0.6	0.7	0.7	-0.8
Bone: tissue strength	2.1	2.0	2.5	-1.3	1.4	-1.5	-1.4	-1.6	-1.4	1.4
Total heroin consumption	2.1	2.4	2.6	1.6	-1.6	1.5	1.6	1.4	1.6	-1.5
Bone: trabecular number	0.4	0.6	1.2	1.1	-1.0	0.7	0.6	0.7	0.7	-0.6
Bone: trabecular spacing	0.1	0.2	0.6	-0.8	0.6	-0.1	-0.1	-0.1	-0.2	0.1
Bone: trabecular thickness	0.3	0.3	0.5	0.2	0.0	-0.7	-0.7	-0.7	-0.6	0.7
Bone: trabecular tissue density	1.8	2.5	3.2	-1.8	1.7	-1.6	-1.4	-1.7	-1.5	1.4
Water consumed over 24 hours	0.7	0.9	1.0	-0.7	0.8	-1.0	-1.0	-1.0	-1.0	1.0
Number of responses in last shaping day	0.2	0.2	0.4	0.5	-0.5	0.4	0.6	0.3	0.4	-0.4