Hub : Genes

Aox2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Aox2	0.07	0.04	1.6e-06	0.03	0.04	0.04	0.04	8.3e-04	8.4e-06	1.2e-05	6.8e-05
2	Brain	gene expression	Aox2	0.04	0.03	2.0e-03	0	0.02	0.02	0.01	1.9e-01	5.1e-03	3.8e-03	2.0e-02
3	Liver	intron excision ratio	chr9_59896869_59897269	0.11	0.07	1.2e-10	0.11	0.09	0.1	0.1	7.9e-12	2.3e-10	1.7e-11	1.7e-11
4	Liver	intron excision ratio	chr9_59896869_59899773	0.11	0.06	2.7e-10	0.1	0.09	0.1	0.1	1.9e-11	4.8e-10	3.8e-11	4.0e-11
5	Liver	gene expression	Aox2	0.86	0.06	0.0e+00	0.65	0.66	0.67	0.67	1.5e-94	4.3e-99	1.1e-100	1.4e-99
6	Liver	mRNA stability	Aox2	0.4	0.19	0.0e+00	0.31	0.29	0.33	0.31	1.8e-35	6.2e-33	1.7e-37	1.8e-34

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.4	0.7	2.8	-0.3	1.1	-0.2	0.2	0.4	1.7
Area under the delay curve	0.1	0.2	0.2	-0.3	-0.2	0.4	-0.4	-0.4	-0.5
BMI with tail	2.1	6.9	14.3	3.8	-2.8	-2.4	2.4	2.6	0.6
BMI without tail	0.9	1.8	7.8	1.5	-2.8	-0.0	0.0	0.2	-0.7
Body weight	0.1	0.3	0.4	-0.6	-0.4	0.6	-0.6	-0.6	-0.3
Weight adjusted by age	0.6	0.7	1.9	0.2	0.6	-0.7	0.7	0.8	1.4
Bone surface	1.0	1.8	4.3	-2.1	1.0	1.4	-1.4	-1.0	0.6
Bone volume	0.5	0.9	1.9	-1.4	1.0	0.8	-0.8	-0.5	1.0
Breakpoint value in progressive ratio session	0.7	0.8	1.9	-0.0	1.1	-0.6	0.6	0.8	1.4
Number of licking bursts	0.3	0.4	0.8	-0.1	0.9	-0.5	0.5	0.5	0.9
Context. condit. distance diff. score	0.2	0.3	0.6	0.7	0.8	-0.5	0.5	0.1	-0.1
Locomotion velocity, session 1	0.3	0.3	0.9	0.6	-0.7	-0.0	0.0	-0.2	-0.9
Locomotion distance, session 1	0.6	0.8	2.0	1.4	-0.3	-0.9	0.9	0.8	0.4
Locomotion velocity, session 2	0.2	0.2	0.8	0.4	-0.9	0.1	-0.1	-0.2	-0.6
Locomotion distance, session 2	1.1	1.5	6.1	0.6	-2.5	0.6	-0.6	-0.5	-1.2
Locomotion velocity, session 3	0.1	0.2	0.4	0.5	-0.6	-0.0	0.0	-0.3	-0.6
Locomotion distance, session 3	0.3	0.3	0.6	-0.5	0.3	0.6	-0.6	-0.7	-0.5
Stereotopy head waving bouts, day 3	0.7	0.8	1.2	1.0	-0.2	-1.0	1.0	1.1	0.6
Stereotopy head waving duration, day 3	1.8	2.1	3.4	1.8	-0.9	-1.6	1.6	1.6	0.9
Locomotion velocity, session 7	0.6	0.7	1.5	1.2	-0.7	-0.9	0.9	0.7	-0.0
Locomotion distance, session 7	0.5	0.7	1.6	-0.0	-0.9	0.7	-0.7	-0.8	-1.3
Stereotopy head waving bouts, day 7	0.3	0.4	1.3	-0.6	1.1	0.1	-0.1	-0.2	0.7
Stereotopy head waving duration, day 7	0.2	0.2	0.6	0.3	0.2	-0.4	0.4	0.3	0.7
Locomotion velocity, session 8	0.0	0.1	0.2	0.4	0.2	-0.2	0.2	-0.1	-0.1
Locomotion distance, session 8	0.1	0.1	0.3	0.5	-0.1	0.0	-0.0	-0.4	-0.6
Degree of sensitization distance	0.3	0.3	0.5	0.7	-0.5	-0.5	0.5	0.5	0.0
Degree of sensitization stereotypy	0.6	0.7	1.1	-1.0	0.5	0.9	-0.9	-1.0	-0.1
Conditioned locomotion	2.1	2.4	3.5	-1.4	-0.7	1.9	-1.9	-1.7	-1.4
Cocaine response after cond. corrected	1.5	1.7	2.4	-1.5	0.7	1.4	-1.4	-1.6	-0.8
Cocaine response after cond. not corrected	1.0	1.1	2.9	-1.3	1.7	0.7	-0.7	-0.8	0.5
Cocaine response before conditioning	2.9	3.5	7.5	0.8	1.8	-1.7	1.7	1.9	2.7
Saline control response	0.4	0.5	1.0	0.6	0.5	-0.7	0.7	0.7	1.0
Bone: connectivity density	0.3	0.5	2.1	0.0	0.0	-0.3	0.3	0.6	1.5
Bone: cortical apparent density	1.0	1.4	2.5	1.6	-1.0	-1.2	1.2	1.2	-0.4
Bone: cortical area	1.0	1.5	3.4	-1.8	0.2	1.4	-1.4	-1.0	-0.8
Bone: cortical porosity	2.0	2.2	4.8	-2.2	1.7	1.4	-1.4	-1.2	0.0
Bone: cortical porosity	2.2	2.4	5.3	-2.3	1.9	1.5	-1.5	-1.3	0.2
Bone: cortical thickness	0.1	0.2	0.6	-0.3	-0.7	0.3	-0.3	-0.0	-0.8
Bone: cortical thickness	1.2	1.4	2.0	1.1	0.4	-1.4	1.4	1.4	1.1
Bone: cortical tissue density	1.1	1.5	2.8	1.7	-1.1	-1.2	1.2	1.2	-0.4
Condit. Reinf. active minus inactive responses	0.9	1.0	2.7	-0.4	1.6	-0.5	0.5	0.7	1.4
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.0	-0.0	0.8	-0.5	0.5	0.7	1.0
Condit. Reinf. active responses	0.7	0.8	2.6	-1.2	1.6	0.3	-0.3	-0.2	0.8
Condit. Reinf. inactive responses	0.6	0.7	1.1	-1.1	0.3	0.9	-0.9	-0.9	-0.5
Incentive salience index mean	1.2	1.4	4.5	-0.9	2.1	-0.3	0.3	0.5	1.7
Condit. Reinf. lever presses	0.6	0.8	3.0	-1.0	1.7	0.1	-0.1	0.0	0.9
Condit. Reinf. active minus inactive responses	1.1	1.4	4.9	-1.3	2.2	0.5	-0.5	-0.4	1.1
Condit. Reinf. active-inactive response ratio	1.9	2.0	7.3	-0.5	2.7	-0.7	0.7	0.5	1.8
Condit. Reinf. active responses	1.0	1.4	4.1	-1.5	2.0	0.8	-0.8	-0.7	0.7
Condit. Reinf. inactive responses	0.4	0.5	0.9	-0.8	-0.1	0.9	-0.9	-0.7	-0.5
Condit. Reinf. lever presses	1.4	1.9	2.8	0.6	1.6	-1.4	1.4	1.4	1.7
Condit. Reinf. lever reinforcers received	1.0	1.4	4.8	-1.4	2.2	0.6	-0.6	-0.5	0.9
Conditioned reinforcement - actives	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.4	-0.4	-0.4
Conditioned reinforcement - inactives	1.4	1.6	2.6	-1.6	0.2	1.5	-1.5	-1.4	-1.0
Conditioned locomotion	0.2	0.2	0.9	0.6	-1.0	-0.1	0.1	0.2	-0.1
Patch foraging indifference point 0 sec	0.3	0.5	0.8	0.6	-0.2	-0.8	0.8	0.9	0.5
Patch foraging indifference point AUC	0.3	0.3	1.0	-0.7	1.0	-0.1	0.1	0.1	0.6
Delay disc. indifference point, 0s delay	1.7	1.8	3.5	1.9	-1.1	-1.4	1.4	1.4	0.4
Delay disc. indifference point, 16s delay	0.2	0.2	0.8	-0.4	0.9	-0.0	0.0	0.0	0.4
Delay disc. indifference point, 2s delay	0.7	0.8	2.0	1.4	-0.9	-0.8	0.8	0.8	0.4
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.2	0.1	-0.1	0.1	0.2	0.1
Delay disc. indifference point, 4s delay	0.2	0.2	0.6	0.8	-0.5	-0.4	0.4	0.2	-0.2
Delay disc. indifference point, 8s delay	1.8	1.9	2.6	-1.6	-0.1	1.6	-1.6	-1.5	-1.0
Indifference point function ln k	0.1	0.1	0.3	0.4	-0.5	0.0	-0.0	-0.0	-0.2
Indifference point function log k	0.1	0.1	0.3	0.4	-0.5	0.0	-0.0	-0.0	-0.2
Patch foraging total patch changes 0 sec	0.8	1.3	1.9	1.0	-0.0	-1.4	1.4	1.4	1.0
Patch foraging total patch changes 12 sec	0.1	0.2	0.3	0.0	0.4	-0.5	0.5	0.5	0.4
Patch foraging total patch changes 18 sec	1.3	1.6	2.5	1.3	-0.3	-1.6	1.6	1.6	0.8
Patch foraging total patch changes 24 sec	0.4	0.5	1.2	-0.2	1.1	-0.6	0.6	0.5	0.8
Patch foraging total patch changes 6 sec	0.9	1.3	2.0	0.9	-0.1	-1.3	1.3	1.4	1.3
Patch foraging time to switch 0 sec	0.3	0.4	0.8	0.9	-0.6	-0.6	0.6	0.7	0.2
Patch foraging water rate 0 sec	0.3	0.4	0.7	-0.9	0.2	0.8	-0.8	-0.8	-0.4
Patch foraging water rate 12 sec	0.3	0.4	0.7	0.8	0.1	-0.6	0.6	0.6	0.8
Patch foraging water rate 18 sec	0.6	0.8	1.7	0.2	1.3	-0.7	0.7	0.6	1.3
Patch foraging water rate 24 sec	0.0	0.0	0.1	0.1	-0.2	0.1	-0.1	-0.1	0.1
Patch foraging water rate 6 sec	0.0	0.0	0.1	0.3	-0.4	-0.1	0.1	0.0	-0.0
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.4	-0.0	0.4	-0.4	-0.2	0.2
Distance traveled before self-admin	0.9	1.0	2.1	-1.4	1.3	0.9	-0.9	-0.7	0.5
Distance traveled after self-admin	0.6	0.7	1.1	-0.9	-0.6	1.0	-1.0	-0.7	-0.7
Extensor digitorum longus weight	0.8	3.0	12.6	1.8	-3.5	-0.6	0.6	0.8	-0.9
Bone: elastic displacement	2.3	2.6	3.4	1.5	0.9	-1.8	1.8	1.7	1.8
Bone: elastic work	0.2	0.3	0.7	0.1	0.5	-0.4	0.4	0.5	0.9
Bone: endosteal estimation	0.9	2.0	4.7	-2.2	1.7	1.3	-1.3	-0.9	0.6
Bone: endosteal perimeter	1.1	2.2	4.5	-2.1	1.4	1.6	-1.6	-1.3	0.2
Epididymis fat weight	2.8	6.4	8.4	-2.4	-1.6	2.9	-2.9	-2.7	-2.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.5	-0.4	0.7	0.2	-0.2	-0.0	0.1
Delta time in open arm before/after self-admin	2.1	2.0	4.1	-2.0	1.9	1.1	-1.1	-1.2	0.1
Diff in mean of infusions in LGA sessions	1.1	1.2	3.3	0.2	1.3	-0.8	0.8	1.0	1.8
Delay discount exponential model param	0.1	0.1	0.2	0.4	0.1	-0.4	0.4	0.4	0.3
Extinction: sum of active levers before priming	0.4	0.4	1.2	0.2	0.5	-0.4	0.4	0.6	1.1
Active lever presses in extinction session 6	0.7	0.6	0.8	-0.8	0.3	0.9	-0.9	-0.9	-0.8
Bone: final force	0.8	1.3	3.1	-1.8	0.2	1.3	-1.3	-0.9	-0.3
Bone: final moment	0.2	0.4	1.2	-1.1	0.2	0.7	-0.7	-0.2	0.2
Food consumed during 24 hour testing period	0.9	1.1	2.2	1.5	-0.6	-1.1	1.1	1.1	0.2
Glucose	0.5	0.7	2.0	1.1	-1.4	-0.5	0.5	0.6	-0.4
Heart weight	0.6	0.9	2.2	0.5	0.4	-0.9	0.9	1.1	1.5
Delay discount hyperbolic model param	0.1	0.1	0.1	0.1	0.2	-0.3	0.3	0.3	0.3
Intermittent access intake day 1-15 change	4.0	3.9	5.6	1.8	0.5	-2.4	2.4	2.3	2.0
Intermittent access intake escalation	4.1	4.0	5.6	1.6	0.9	-2.4	2.4	2.3	2.1
Intermittent access intake escalation 2	2.6	2.6	3.6	1.0	1.2	-1.8	1.8	1.7	1.9
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.4	0.6	-0.6	-0.3	0.3	0.3	-0.5
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	0.0	0.4	-0.3	0.3	0.4	0.5
Intermitt. access escalation Index	2.7	2.4	3.6	-0.8	-1.8	1.6	-1.6	-1.4	-1.9
Intermittent access day 1 total infusions	0.2	0.2	0.5	-0.4	0.1	0.4	-0.4	-0.6	-0.7
Intermittent access day 15 total infusions	1.0	1.1	1.5	0.8	0.5	-1.2	1.2	1.2	1.0
Intermittent access terminal intake (last 3 days)	1.6	1.7	2.3	1.1	0.8	-1.5	1.5	1.5	1.4
Intermittent access total infusions	0.2	0.2	0.3	0.3	0.5	-0.5	0.5	0.5	0.3
Intermittent access day 1 locomotion	0.0	0.0	0.2	-0.0	0.2	-0.1	0.1	0.1	-0.4
Intermittent access day 15 total locomotion	0.4	0.4	0.6	0.3	0.5	-0.8	0.8	0.8	0.6
Intermittent access total locomotion	0.0	0.0	0.1	0.1	0.0	-0.2	0.2	0.1	-0.3
Intermittent access standard deviation	2.1	2.2	3.4	1.2	1.3	-1.8	1.8	1.4	1.1
Left kidney weight	0.1	0.2	0.6	-0.0	-0.8	-0.1	0.1	0.5	0.5
Right kidney weight	0.0	0.1	0.2	-0.2	-0.3	-0.1	0.1	0.3	0.4
Cocaine induced anxiety	0.3	0.3	1.6	0.2	-1.3	0.1	-0.1	-0.1	-0.2
Post-drug Anxiety	0.1	0.1	0.5	0.5	-0.7	-0.0	0.0	0.0	0.3
Baseline Anxiety	0.4	0.4	1.8	-0.7	1.3	0.3	-0.3	-0.5	-0.0
Tail length	3.9	11.8	22.8	-4.8	1.8	3.8	-3.8	-3.7	-1.4
Length with tail	3.6	13.1	27.5	-5.2	2.7	3.7	-3.7	-3.8	-1.2
Length without tail	0.8	1.7	4.6	-2.0	2.1	0.7	-0.7	-0.8	0.3
Times rat made contact with spout	0.5	0.5	1.2	1.1	-0.9	-0.6	0.6	0.4	-0.4
Lifetime Intake	0.1	0.1	0.2	0.4	0.1	-0.5	0.5	0.4	0.0
Liver weight, left	1.5	2.4	3.4	-1.3	-0.8	1.8	-1.8	-1.7	-1.4
Liver weight, right	0.7	1.2	3.9	-1.2	2.0	0.4	-0.4	-0.2	1.3
Locomotor activity	0.3	0.4	2.0	0.5	-1.4	0.0	-0.0	0.2	-0.5
Locomotor testing distance	1.0	1.6	2.8	1.7	-1.4	-1.2	1.2	1.3	0.5
Locomotor testing rearing	0.1	0.1	0.1	0.1	-0.4	0.4	-0.4	-0.2	-0.3
Locomotion in novel chamber	9.0	11.1	14.7	3.3	0.5	-3.8	3.8	3.8	3.4
Locomotion in novel chamber post-restriction	0.5	0.6	1.2	0.2	0.7	-0.8	0.8	0.8	1.1
Fecal boli incidents, locomotor time 1	0.3	0.3	1.5	-0.5	1.2	-0.2	0.2	0.1	0.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	0.3	-0.6	-0.3	0.3	0.3	-0.1
Time >=10cm from walls, locomotor time 1	0.7	0.7	0.9	-1.0	0.0	0.9	-0.9	-0.8	-0.8
Bouts of movement, locomotor time 1	1.0	1.1	3.7	-0.2	1.9	-0.8	0.8	0.7	0.9
Total resting periods, locomotor time 1	0.8	0.9	2.5	0.2	1.6	-1.0	1.0	0.7	0.7
Rest time, locomotor task time 1	0.2	0.2	1.1	0.3	-0.4	-0.3	0.3	0.0	-1.0
Distance moved, locomotor task time 1	2.2	2.4	4.2	-1.7	-0.3	2.0	-2.0	-1.7	-0.7
Vertical activity count, locomotor time 1	0.9	1.0	1.7	-0.8	-0.3	1.3	-1.3	-1.1	-0.6
Time >=10cm from walls, locomotor time 2	1.0	1.0	3.5	0.1	-1.9	0.7	-0.7	-0.6	-1.2
Bouts of movement, locomotor time 2	0.3	0.3	0.5	0.6	-0.1	-0.6	0.6	0.6	0.7
Total resting periods, locomotor time 2	0.4	0.5	0.7	0.5	0.2	-0.8	0.8	0.8	0.8
Rest time, locomotor task time 2	0.1	0.2	0.8	-0.2	0.3	-0.0	0.0	-0.2	-0.9
Distance moved, locomotor task time 2	0.4	0.4	0.7	-0.4	-0.9	0.9	-0.9	-0.5	-0.1
Vertical activity count, locomotor time 2	1.4	1.5	4.6	1.6	-2.2	-0.7	0.7	0.9	0.3
Light reinforcement 1	2.0	3.6	7.3	2.5	-2.7	-1.6	1.6	1.5	-0.6
Light reinforcement 2	0.1	0.2	0.7	-0.1	-0.8	0.2	-0.2	-0.2	-0.4
Bone: marrow area	0.9	2.0	4.6	-2.2	1.8	1.3	-1.3	-0.9	0.7
Bone: maximum diameter	1.8	3.3	7.2	-2.7	1.3	1.9	-1.9	-1.7	-0.7
Bone: maximum force	0.3	0.5	1.5	-1.2	0.1	0.8	-0.8	-0.3	0.4
Bone: maximum moment	0.1	0.2	0.9	-0.4	0.1	0.1	-0.1	0.4	0.9
Mean time between licks in bursts	2.0	2.8	6.2	-0.4	-2.5	1.3	-1.3	-1.3	-2.3
Mean num. licks in bursts	0.7	0.9	3.0	0.9	-1.7	0.1	-0.1	-0.2	-1.2
Cd content in liver	0.1	0.1	0.1	-0.3	0.2	0.3	-0.3	-0.3	-0.0
Co content in liver	1.2	1.4	2.9	0.7	1.7	-1.2	1.2	0.9	1.2
Cu content in liver	0.3	0.4	0.9	-1.0	0.1	0.7	-0.7	-0.6	-0.2
Fe content in liver	1.1	1.3	3.2	0.4	1.1	-0.9	0.9	1.1	1.8
K content in liver	1.0	1.0	1.5	-1.2	0.7	1.1	-1.1	-1.1	-0.6
Mg content in liver	0.0	0.0	0.1	-0.1	0.2	0.1	-0.1	-0.0	0.2
Mn content in liver	1.6	1.8	2.8	1.5	0.3	-1.7	1.7	1.4	0.8
Na content in liver	0.6	0.7	1.6	-1.3	1.0	0.7	-0.7	-0.6	0.0
Rb content in liver	1.2	1.4	2.3	-1.2	-0.1	1.4	-1.4	-1.5	-0.9
Se content in liver	0.3	0.3	0.6	0.5	-0.1	-0.5	0.5	0.8	0.7
Sr content in liver	0.8	0.8	2.1	-0.4	-0.8	0.7	-0.7	-0.8	-1.4
Zn content in liver	0.4	0.5	1.2	-0.0	-1.1	0.5	-0.5	-0.4	-1.0
Bone: minimum diameter	0.7	1.2	3.4	-1.8	0.5	1.3	-1.3	-0.7	-0.1
Time in familiar zone, hab. session 1	1.8	1.7	2.9	1.0	0.7	-1.4	1.4	1.3	1.7
Time in novel zone, hab. session 1	1.4	1.4	2.4	-1.0	-0.3	1.3	-1.3	-1.2	-1.5
Total zone transitions, hab. session 1	0.2	0.3	0.9	-0.4	0.9	0.4	-0.4	-0.5	0.1
Total locomotion distance, hab. session 1	0.7	1.0	4.2	-0.6	2.0	-0.1	0.1	0.2	1.2
Locomotion velocity, hab. session 1	0.4	0.6	2.5	-0.7	1.6	0.1	-0.1	0.0	0.9
Time in familiar zone, hab. session 2	1.7	1.7	2.2	0.9	1.0	-1.5	1.5	1.4	1.4
Time in novel zone, hab. session 2	0.9	0.9	1.8	-0.1	-1.3	0.8	-0.8	-0.8	-1.2
Total zone transitions, hab. session 2	0.2	0.3	0.9	0.9	-0.8	-0.2	0.2	0.1	-0.4
Total locomotion distance, hab. session 2	0.2	0.3	0.8	0.9	-0.9	-0.2	0.2	0.3	-0.1
Locomotion velocity, hab. session 2	0.2	0.3	0.9	0.7	-0.9	-0.1	0.1	0.2	-0.2
Novel to familiar place preference ratio	0.1	0.1	0.4	0.4	-0.7	0.1	-0.1	-0.2	-0.4
Novelty place preference	0.1	0.1	0.3	0.4	-0.6	0.0	-0.0	-0.1	-0.2
Time in novel zone, NPP test	0.1	0.1	0.4	0.6	-0.5	-0.2	0.2	0.1	-0.0
Total zone transitions, NPP test	0.0	0.1	0.3	0.2	0.5	-0.1	0.1	0.0	0.2
Total locomotion distance, NPP test	1.1	1.5	2.4	1.1	0.8	-1.2	1.2	1.4	1.6
Locomotion velocity, NPP test	1.0	1.3	1.9	1.1	0.6	-1.2	1.2	1.3	1.4
Intraocular pressure	2.3	3.2	5.9	2.4	-1.0	-1.9	1.9	2.0	0.9
Delta distance traveled before/after self-admin	0.5	0.6	2.5	0.7	-1.6	-0.0	0.0	0.2	-0.6
Delta ambulatory time before/after self-admin	0.8	0.9	2.8	0.3	-1.7	0.5	-0.5	-0.3	-1.3
Parametrial fat weight	0.3	0.6	0.9	-0.4	-0.9	0.7	-0.7	-0.7	-0.9
Pavlov. Cond. lever latency	0.6	0.7	2.9	0.8	-1.7	-0.1	0.1	0.0	-1.0
Pavlov. Cond. magazine entry latency	1.2	1.5	4.1	-0.5	2.0	-0.6	0.6	0.8	1.8
Pavlov. Cond. change in total contacts	1.2	1.3	3.2	0.0	1.7	-0.8	0.8	0.9	1.8
Pavlov. Cond. index score	1.3	1.7	6.0	-0.7	2.4	-0.5	0.5	0.5	1.7
Pavlov. Cond. latency score	1.4	1.8	6.4	-0.7	2.5	-0.4	0.4	0.5	1.8
Pavlov. Cond. lever contacts	0.9	1.1	3.2	-0.2	1.8	-0.6	0.6	0.6	1.5
Pavlov. Cond. magazine entry number	0.7	0.9	2.7	0.5	-1.7	0.3	-0.3	-0.5	-1.4
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	-0.5	-0.1	0.6	-0.6	-0.7	-0.5
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.8	5.8	-0.4	2.4	-0.7	0.7	0.8	1.8
Pavlov. Cond. response bias	1.0	1.2	4.2	-0.7	2.0	-0.3	0.3	0.4	1.4
Pavlov. Cond. lever latency	1.4	1.9	3.4	-0.5	-1.9	1.4	-1.4	-1.3	-1.6
Pavlov. Cond. magazine entry latency	0.4	0.4	1.2	0.2	1.1	-0.6	0.6	0.5	0.4
Pavlov. Cond. change in total contacts	0.9	1.3	5.3	-1.4	2.3	0.2	-0.2	-0.3	0.5
Pavlov. Cond. index score	0.7	0.9	3.8	-0.3	1.9	-0.6	0.6	0.5	0.8
Pavlov. Cond. latency score	0.7	0.9	3.5	-0.2	1.9	-0.6	0.6	0.5	0.8
Pavlov. Cond. lever contacts	1.2	1.7	4.0	0.1	2.0	-1.1	1.1	1.1	1.5
Pavlov. Cond. magazine entry number	0.3	0.3	1.5	0.3	-1.2	0.2	-0.2	-0.2	-0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	0.7	-0.7	-0.3	0.3	0.5	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	3.8	-0.5	1.9	-0.4	0.4	0.3	0.6
Pavlov. Cond. response bias	0.7	1.0	3.1	-0.0	1.8	-0.8	0.8	0.7	1.1
Time in closed arm before self-admin	0.6	0.7	1.5	-1.2	1.1	0.7	-0.7	-0.7	0.3
Time in closed arm after self-admin	0.6	0.6	2.1	-0.9	1.5	0.5	-0.5	-0.5	0.5
Time in open arm before self-admin	1.7	1.8	7.1	1.5	-2.7	-0.3	0.3	0.5	-1.0
Time in open arm after self-admin	0.7	0.8	1.5	-1.2	0.6	0.9	-0.9	-1.0	-0.6
Bone: periosteal estimation	1.3	2.6	6.6	-2.6	1.3	1.7	-1.7	-1.2	-0.0
Bone: periosteal perimeter	0.8	1.3	3.1	-1.8	1.2	1.2	-1.2	-0.8	0.2
Bone: post-yield work	0.8	1.1	1.7	1.0	-0.4	-1.2	1.2	1.3	1.2
Progressive ratio test 1 active lever presses	0.2	0.2	0.3	0.3	-0.2	-0.5	0.5	0.5	0.0
Progressive ratio test 1 breakpoint	0.5	0.5	0.9	0.6	0.1	-0.9	0.9	0.9	0.5
Progressive ratio test 1 inactive lever presses	1.2	1.3	4.1	1.6	-2.0	-0.5	0.5	0.6	-0.7
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.1	0.2	0.1
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	0.4	-0.1	-0.5	0.5	0.6	0.4
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.3	0.1	-0.4	0.2	-0.2	-0.1	-0.5
Incentive Sensitization - Responses	0.9	0.9	1.2	-1.1	-0.2	1.1	-1.1	-1.0	-0.8
Incentive Sensitization - Breakpoint	1.0	1.0	1.3	-1.1	-0.3	1.2	-1.2	-1.1	-0.9
Sum of active levers in priming session hrs 5-6	1.0	0.9	1.8	-1.3	0.2	1.1	-1.1	-0.9	-0.7
Progressive ratio	0.4	0.5	1.3	0.3	-1.2	0.2	-0.2	-0.2	-1.1
Food seeking constrained by brief footshock	0.2	0.2	0.8	-0.2	0.5	-0.1	0.1	0.2	0.9
Seeking ratio, punishment vs. effort	0.5	0.6	1.6	-0.6	1.2	-0.0	0.0	0.0	1.3
Retroperitoneal fat weight	0.2	0.7	1.5	-0.1	-1.0	0.7	-0.7	-0.9	-1.2
Reaction time number correct	0.8	1.2	1.6	1.3	0.1	-1.2	1.2	1.2	1.2
Reaction time mean minus median	0.0	0.0	0.1	-0.1	0.2	0.1	-0.1	-0.0	0.0
Reaction time mean minus median AUC	0.5	0.6	0.9	0.5	1.0	-0.7	0.7	0.8	0.9
Reaction time num false alarms	0.9	1.3	5.2	0.9	-2.3	0.2	-0.2	-0.1	-1.2
Reaction time num false alarms AUC	1.1	1.5	6.1	0.9	-2.5	0.2	-0.2	-0.1	-1.3
Reaction time trials correct on left	0.8	1.2	1.6	1.3	0.1	-1.2	1.2	1.2	1.2
Reaction time trials on left	0.8	1.1	1.5	1.2	0.1	-1.1	1.1	1.2	1.1
Reaction time mean	2.5	3.5	5.3	-2.3	0.7	2.0	-2.0	-2.1	-1.6
Reaction time mean AUC	2.1	2.8	4.2	-2.1	0.6	1.8	-1.8	-1.9	-1.5
Median of all reaction times	3.9	5.4	8.5	-2.9	0.9	2.4	-2.4	-2.6	-2.0
Reaction time omissions	0.5	0.7	0.9	-0.8	0.0	0.9	-0.9	-1.0	-0.9
Reaction time false alarm rate	1.1	1.6	4.5	0.1	-2.1	0.8	-0.8	-0.8	-1.7
Reaction time premature initiation rate	1.9	2.6	4.3	0.9	0.7	-1.8	1.8	1.9	2.1
Reaction time premature initiations	3.0	4.2	6.2	1.6	0.6	-2.3	2.3	2.5	2.5
Std. dev. reaction times	0.5	0.7	1.2	-1.1	0.7	1.0	-1.0	-0.8	-0.3
Reaction time trials completed	0.8	1.1	1.5	1.2	0.1	-1.1	1.1	1.2	1.1
Reaction time trials AUC	0.6	0.8	1.1	1.1	0.1	-1.0	1.0	1.0	1.0
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.1	-0.2	0.1	-0.1	-0.3	-0.4
Run reversals in cocaine runway, males	0.4	0.4	1.4	-0.0	1.2	-0.5	0.5	0.3	0.6
Latency to leave start box in cocaine runway	1.7	1.9	4.6	2.1	-1.5	-1.2	1.2	1.2	0.0
Latency to leave start box in cocaine runway, F	0.4	0.5	1.4	1.2	-0.8	-0.5	0.5	0.5	-0.4
Latency to leave start box in cocaine runway, M	3.8	3.6	5.1	2.0	-0.3	-2.1	2.1	2.3	1.9
Std. dev. time between licks in bursts	0.5	0.6	1.5	0.9	-1.2	-0.6	0.6	0.6	-0.0
Total sessions with >9 infusions	0.5	0.6	1.2	1.1	-0.6	-0.8	0.8	0.8	0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.0	-0.4	0.4	-0.4	-0.3	-0.1
Short access day 10 total inactive lever presses	0.2	0.2	0.4	-0.1	-0.3	0.5	-0.5	-0.6	-0.5
Short access day 1 total infusions	0.5	0.6	1.1	1.0	0.0	-0.8	0.8	0.8	0.5
Short access day 10 total infusions	0.2	0.2	0.3	0.4	0.2	-0.5	0.5	0.4	0.4
Short access total infusions	0.2	0.3	0.7	0.8	-0.2	-0.6	0.6	0.4	-0.1
Short access day 1 locomotion	0.0	0.0	0.1	0.2	-0.2	-0.1	0.1	0.3	0.0
Short access day 10 total locomotion	0.3	0.4	0.8	0.2	0.9	-0.6	0.6	0.6	0.4
Short access total locomotion	0.1	0.1	0.2	0.5	-0.2	-0.2	0.2	0.2	-0.2
One hour access (0.3 mA shock)	0.9	1.1	2.2	0.1	1.5	-1.1	1.1	0.9	0.8
Compulsive drug intake	0.3	0.3	0.8	-0.1	0.9	-0.4	0.4	0.4	0.5
One hour access (shock baseline)	0.0	0.0	0.1	-0.1	0.3	-0.2	0.2	0.1	0.0
Social response proportion	0.7	0.7	1.3	-1.0	0.1	1.1	-1.1	-0.8	-0.1
Social responses	1.6	2.1	3.3	-1.7	-0.0	1.8	-1.8	-1.5	-0.9
Social time	0.3	0.4	0.7	-0.9	0.3	0.7	-0.7	-0.5	-0.1
Soleus weight	0.1	0.4	2.2	0.3	-1.5	0.1	-0.1	0.2	0.2
Bone: stiffness	1.7	2.6	5.4	-2.3	0.5	1.9	-1.9	-1.6	-0.5
Tibialis anterior weight	0.0	0.1	0.3	0.1	-0.6	0.1	-0.1	-0.0	-0.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.4	-0.1	-0.6	0.2	-0.2	-0.1	-0.6
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.5	-0.0	-0.7	0.2	-0.2	-0.3	-0.3
Time to tail flick, test, before self-admin	1.2	1.1	1.6	-0.7	-0.8	1.2	-1.2	-1.1	-1.3
Time to tail flick, test, after self-admin	1.7	1.7	3.4	1.8	-0.3	-1.4	1.4	1.4	0.9
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.7	0.8	-0.5	-0.5	0.5	0.4	0.5
Delta time to tail flick, test, before/after SA	4.4	3.9	5.4	2.1	0.4	-2.3	2.3	2.2	1.8
Tibia length	2.1	5.9	13.1	-3.6	1.8	2.6	-2.6	-2.3	-0.5
Ambulatory time before self-admin	0.6	0.6	1.1	-1.0	0.2	1.0	-1.0	-0.8	0.1
Ambulatory time after self-admin	0.5	0.6	1.6	-0.4	-1.2	0.8	-0.8	-0.4	-0.6
Bone: tissue strength	0.2	0.2	0.9	-0.0	-0.9	0.4	-0.4	-0.1	-0.0
Total heroin consumption	0.2	0.2	0.5	0.1	0.1	-0.4	0.4	0.7	0.7
Bone: trabecular number	0.2	0.4	1.6	-0.5	0.6	0.1	-0.1	0.1	1.3
Bone: trabecular spacing	0.5	0.7	2.4	-0.3	-0.4	0.6	-0.6	-0.8	-1.6
Bone: trabecular thickness	0.6	0.7	2.1	0.5	0.4	-0.7	0.7	0.9	1.4
Bone: trabecular tissue density	0.2	0.3	0.7	-0.9	0.7	0.3	-0.3	-0.3	-0.5
Water consumed over 24 hours	4.1	4.9	7.6	2.8	-0.8	-2.5	2.5	2.5	1.5
Number of responses in last shaping day	0.3	0.3	0.6	0.3	-0.1	-0.5	0.5	0.7	0.8