Hub : Genes

Ankrd52

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IL	mRNA stability	Ankrd52	0.17	0.12	9.8e-03	0.04	0.03	0.06	0.04	3.1e-02	6.9e-02	2.0e-02	4.2e-02
2	Adipose	gene expression	Ankrd52	0.09	0.06	3.7e-08	0.06	0.06	0.06	0.06	2.0e-07	1.8e-07	1.1e-07	3.4e-07
3	Adipose	mRNA stability	Ankrd52	0.08	0.06	1.5e-05	0.03	0.02	0.03	0.02	2.4e-04	1.6e-03	3.4e-04	1.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	2.3	4.2	7.0	1.0	-2.2	2.6
Area under the delay curve	0.0	0.0	0.0	0.2	-0.2	0.2
BMI with tail	3.4	11.8	28.3	5.3	2.5	-1.0
BMI without tail	0.5	2.7	5.9	2.4	1.3	-0.8
Body weight	0.6	2.6	3.9	2.0	1.6	-1.1
Weight adjusted by age	0.0	0.1	0.1	-0.3	0.2	-0.3
Bone surface	4.6	9.1	14.3	0.9	-3.5	3.8
Bone volume	4.7	9.4	14.9	1.2	-3.4	3.9
Breakpoint value in progressive ratio session	0.3	0.5	1.2	-1.1	-0.4	0.1
Number of licking bursts	1.0	2.9	3.3	1.6	1.8	-1.7
Context. condit. distance diff. score	0.2	0.2	0.3	0.5	0.4	-0.6
Locomotion velocity, session 1	1.4	1.6	2.8	0.6	-1.3	1.7
Locomotion distance, session 1	2.1	2.7	4.9	0.1	-1.8	2.2
Locomotion velocity, session 2	3.3	3.9	6.4	-0.6	-2.2	2.5
Locomotion distance, session 2	3.9	5.5	8.0	-1.5	-2.5	2.8
Locomotion velocity, session 3	1.9	2.2	5.9	-2.4	-0.9	0.1
Locomotion distance, session 3	0.1	0.1	0.2	-0.5	0.1	0.0
Stereotopy head waving bouts, day 3	2.7	3.2	5.8	-2.4	-1.6	1.2
Stereotopy head waving duration, day 3	1.5	1.9	3.3	-1.8	-1.2	0.9
Locomotion velocity, session 7	0.2	0.2	0.3	-0.0	-0.6	0.5
Locomotion distance, session 7	0.6	0.7	1.3	0.0	1.0	-1.1
Stereotopy head waving bouts, day 7	1.3	1.5	2.5	-0.7	-1.6	1.3
Stereotopy head waving duration, day 7	1.7	2.0	3.3	-0.5	-1.8	1.6
Locomotion velocity, session 8	2.8	3.4	4.8	-0.8	-2.2	2.2
Locomotion distance, session 8	0.4	0.6	0.7	-0.6	-0.8	0.8
Degree of sensitization distance	0.3	0.4	0.8	0.9	0.3	-0.5
Degree of sensitization stereotypy	0.5	0.6	0.9	0.4	-0.8	0.9
Conditioned locomotion	1.7	2.0	3.3	0.4	1.8	-1.6
Cocaine response after cond. corrected	1.9	2.9	4.1	1.2	2.0	-1.7
Cocaine response after cond. not corrected	2.1	3.0	4.4	1.2	2.1	-1.8
Cocaine response before conditioning	0.4	0.5	0.6	-0.8	-0.8	0.6
Saline control response	0.3	0.5	1.0	0.4	1.0	-0.5
Bone: connectivity density	1.5	2.4	4.4	0.6	-1.6	2.1
Bone: cortical apparent density	0.5	0.8	2.2	1.5	0.4	0.0
Bone: cortical area	1.3	2.1	2.5	1.6	-1.2	1.5
Bone: cortical porosity	0.4	0.4	0.6	0.2	-0.7	0.8
Bone: cortical porosity	0.9	1.0	1.4	0.7	-1.0	1.2
Bone: cortical thickness	0.9	1.5	3.8	1.9	-0.3	0.8
Bone: cortical thickness	0.5	0.6	0.9	0.6	0.9	-0.7
Bone: cortical tissue density	0.4	0.6	1.6	1.3	0.3	0.1
Condit. Reinf. active minus inactive responses	0.8	0.9	1.9	-1.4	-0.8	0.5
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.3	-0.5	0.3	-0.3
Condit. Reinf. active responses	1.7	2.2	2.7	-1.6	-1.6	1.2
Condit. Reinf. inactive responses	1.5	2.0	3.3	-1.1	-1.8	1.2
Incentive salience index mean	1.1	1.4	1.8	-1.0	-1.3	1.2
Condit. Reinf. lever presses	1.6	2.4	3.6	-0.2	-1.9	1.9
Condit. Reinf. active minus inactive responses	1.0	1.6	3.9	-2.0	0.3	-0.9
Condit. Reinf. active-inactive response ratio	1.3	2.0	2.8	-1.4	1.2	-1.7
Condit. Reinf. active responses	0.6	0.9	2.4	-1.5	-0.4	-0.1
Condit. Reinf. inactive responses	0.3	0.5	0.8	-0.4	-0.9	0.6
Condit. Reinf. lever presses	1.0	1.5	4.3	-2.1	-0.0	-0.5
Condit. Reinf. lever reinforcers received	0.5	0.7	2.0	-1.4	-0.0	-0.5
Conditioned reinforcement - actives	0.1	0.2	0.7	0.8	0.2	-0.1
Conditioned reinforcement - inactives	0.3	0.8	1.0	0.9	1.0	-0.8
Conditioned locomotion	0.6	0.8	1.3	-0.8	-1.1	0.8
Patch foraging indifference point 0 sec	1.0	2.9	8.4	2.9	0.4	0.4
Patch foraging indifference point AUC	0.2	0.5	1.4	-1.2	-0.1	-0.4
Delay disc. indifference point, 0s delay	1.9	2.2	2.9	1.7	-1.1	1.5
Delay disc. indifference point, 16s delay	0.1	0.2	0.2	-0.5	-0.4	0.3
Delay disc. indifference point, 2s delay	0.5	0.5	0.7	0.7	-0.7	0.8
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	0.4	0.1	-0.0
Delay disc. indifference point, 4s delay	0.8	0.8	1.3	-0.2	-1.2	1.1
Delay disc. indifference point, 8s delay	0.3	0.4	0.6	0.3	0.8	-0.8
Indifference point function ln k	0.0	0.1	0.3	0.6	0.2	0.2
Indifference point function log k	0.0	0.1	0.3	0.6	0.2	0.2
Patch foraging total patch changes 0 sec	0.9	2.6	7.5	2.7	0.4	0.3
Patch foraging total patch changes 12 sec	1.0	1.3	1.8	1.3	1.2	-0.8
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	0.2	-0.2	0.3
Patch foraging total patch changes 24 sec	0.1	0.3	0.8	0.9	-0.3	0.3
Patch foraging total patch changes 6 sec	0.7	1.2	3.6	1.9	0.4	-0.1
Patch foraging time to switch 0 sec	0.2	0.6	0.8	0.8	-0.6	0.9
Patch foraging water rate 0 sec	0.3	1.2	1.7	0.5	1.3	-1.3
Patch foraging water rate 12 sec	0.3	1.2	2.0	0.8	1.4	-1.0
Patch foraging water rate 18 sec	1.6	3.6	5.6	-0.7	2.2	-2.4
Patch foraging water rate 24 sec	4.2	6.0	8.9	0.5	3.0	-3.0
Patch foraging water rate 6 sec	1.2	1.7	2.5	-1.1	1.2	-1.6
Seeking ratio, delayed vs. immediate footshock	0.7	1.0	1.5	-0.7	-1.2	1.0
Distance traveled before self-admin	0.4	0.8	1.7	-1.3	-0.7	0.4
Distance traveled after self-admin	0.0	0.0	0.1	-0.3	-0.0	-0.0
Extensor digitorum longus weight	2.6	10.2	17.0	4.1	3.3	-1.7
Bone: elastic displacement	0.0	0.1	0.1	0.2	-0.2	0.3
Bone: elastic work	0.6	0.7	1.7	1.3	-0.3	0.6
Bone: endosteal estimation	0.3	0.8	2.4	1.5	-0.4	0.2
Bone: endosteal perimeter	0.5	1.3	2.1	-0.1	-1.4	1.3
Epididymis fat weight	0.2	0.9	1.2	-0.6	1.0	-1.1
Delta time in closed arm before/after self-admin	3.8	3.6	5.5	0.7	2.3	-2.2
Delta time in open arm before/after self-admin	0.2	0.2	0.5	0.7	0.4	-0.2
Diff in mean of infusions in LGA sessions	0.5	0.9	2.4	-1.6	-0.4	0.0
Delay discount exponential model param	0.0	0.0	0.0	-0.1	0.2	-0.2
Extinction: sum of active levers before priming	0.7	1.1	2.3	-1.5	0.4	-0.8
Active lever presses in extinction session 6	0.2	0.2	0.3	-0.3	-0.5	0.5
Bone: final force	1.6	2.6	6.6	2.6	-0.7	0.9
Bone: final moment	1.6	2.6	6.6	2.6	-0.7	0.9
Food consumed during 24 hour testing period	0.1	0.2	0.4	0.7	0.2	-0.1
Glucose	0.5	0.7	1.5	1.2	0.7	-0.5
Heart weight	0.2	0.4	0.5	-0.7	0.6	-0.6
Delay discount hyperbolic model param	0.1	0.2	0.2	-0.4	0.3	-0.4
Intermittent access intake day 1-15 change	0.1	0.4	0.6	-0.7	0.5	-0.7
Intermittent access intake escalation	0.1	0.4	0.6	-0.8	0.5	-0.7
Intermittent access intake escalation 2	0.2	0.4	1.1	-1.0	0.0	-0.3
Intermitt. access day 1 inactive lever presses	0.2	2.1	2.4	-1.5	1.3	-1.5
Intermitt. access day 15 inactive lever presses	0.1	0.5	1.5	-1.2	-0.1	-0.2
Intermitt. access escalation Index	0.2	0.5	0.8	0.2	-0.8	0.9
Intermittent access day 1 total infusions	0.1	0.2	0.3	0.5	0.6	-0.4
Intermittent access day 15 total infusions	0.0	0.0	0.1	0.3	0.0	0.0
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.4	0.4	-0.6	0.6
Intermittent access total infusions	0.2	0.2	0.7	0.8	0.0	0.1
Intermittent access day 1 locomotion	0.4	0.7	1.0	-0.1	1.0	-1.0
Intermittent access day 15 total locomotion	0.0	0.2	0.3	-0.2	0.4	-0.5
Intermittent access total locomotion	0.1	0.1	0.1	0.0	0.3	-0.4
Intermittent access standard deviation	0.1	0.5	0.6	-0.7	-0.8	0.6
Left kidney weight	0.0	0.2	0.3	-0.2	0.4	-0.6
Right kidney weight	0.1	0.7	1.2	-1.1	0.5	-0.9
Cocaine induced anxiety	0.9	2.3	3.4	-1.0	-1.9	1.6
Post-drug Anxiety	2.8	3.2	5.0	-0.3	-2.2	2.2
Baseline Anxiety	0.0	0.0	0.0	0.1	-0.0	0.1
Tail length	1.1	6.1	17.2	-4.1	-1.0	-0.3
Length with tail	0.7	3.2	8.9	-3.0	-0.1	-0.8
Length without tail	0.1	0.7	1.1	0.7	1.0	-0.8
Times rat made contact with spout	0.7	0.9	1.2	0.8	1.1	-0.8
Lifetime Intake	0.6	0.8	2.2	1.5	0.0	0.3
Liver weight, left	0.3	0.4	0.9	0.9	0.6	-0.3
Liver weight, right	0.3	0.5	0.7	-0.8	0.4	-0.8
Locomotor activity	2.1	3.3	3.8	-1.9	-2.0	1.5
Locomotor testing distance	0.7	1.6	2.2	-1.2	-1.5	1.1
Locomotor testing rearing	0.0	0.1	0.2	-0.3	0.3	-0.4
Locomotion in novel chamber	0.0	0.0	0.0	0.1	0.1	-0.1
Locomotion in novel chamber post-restriction	1.0	2.9	7.4	-2.7	-1.1	0.5
Fecal boli incidents, locomotor time 1	0.3	0.9	1.4	0.3	1.2	-1.0
Change in fecal boli incidents, locomotor task	1.5	1.6	2.4	-0.5	-1.6	1.4
Time >=10cm from walls, locomotor time 1	0.8	1.0	1.2	0.9	-0.9	1.1
Bouts of movement, locomotor time 1	0.2	0.3	0.9	-1.0	-0.1	-0.1
Total resting periods, locomotor time 1	0.5	0.6	1.7	-1.3	-0.4	0.1
Rest time, locomotor task time 1	0.4	0.6	0.8	-0.9	-0.9	0.6
Distance moved, locomotor task time 1	0.5	1.4	2.3	1.5	-0.9	1.1
Vertical activity count, locomotor time 1	0.2	1.2	3.0	1.7	0.7	-0.2
Time >=10cm from walls, locomotor time 2	0.3	0.8	1.0	0.8	1.0	-0.9
Bouts of movement, locomotor time 2	0.3	0.9	1.4	-0.2	-1.1	1.2
Total resting periods, locomotor time 2	0.3	1.2	1.9	-0.2	-1.3	1.4
Rest time, locomotor task time 2	0.4	0.7	1.0	-0.3	-1.0	1.0
Distance moved, locomotor task time 2	0.4	0.6	0.9	0.2	0.8	-1.0
Vertical activity count, locomotor time 2	0.8	1.9	2.7	1.0	1.6	-1.4
Light reinforcement 1	0.7	3.3	5.1	-2.3	-1.8	1.3
Light reinforcement 2	0.4	0.8	1.3	-1.2	-0.8	0.7
Bone: marrow area	0.3	0.7	2.1	1.4	-0.4	0.2
Bone: maximum diameter	1.1	2.1	3.2	-0.2	-1.8	1.8
Bone: maximum force	1.3	2.5	6.7	2.6	-0.4	0.8
Bone: maximum moment	1.3	2.5	6.8	2.6	-0.4	0.8
Mean time between licks in bursts	0.0	0.3	0.9	-0.9	0.1	-0.1
Mean num. licks in bursts	0.3	0.7	0.9	-0.8	-0.8	0.9
Cd content in liver	0.0	0.1	0.1	-0.3	-0.2	0.2
Co content in liver	1.0	1.2	3.6	-1.9	-0.1	-0.1
Cu content in liver	0.9	1.1	1.3	1.0	-1.0	1.2
Fe content in liver	0.3	0.4	0.4	0.5	0.6	-0.6
K content in liver	1.0	1.0	1.3	-0.5	-1.2	1.1
Mg content in liver	0.8	0.8	1.0	-1.0	-1.0	0.7
Mn content in liver	4.2	4.7	7.5	-0.5	-2.7	2.5
Na content in liver	0.5	0.5	0.8	0.4	-0.8	0.9
Rb content in liver	1.0	1.1	1.5	0.7	-1.1	1.2
Se content in liver	0.0	0.0	0.0	-0.0	-0.0	0.2
Sr content in liver	0.4	0.4	0.7	-0.3	0.6	-0.8
Zn content in liver	2.6	3.0	5.7	-2.4	1.0	-1.5
Bone: minimum diameter	0.7	1.3	1.9	1.1	-1.0	1.4
Time in familiar zone, hab. session 1	1.9	2.1	6.2	-2.5	-0.4	-0.3
Time in novel zone, hab. session 1	1.9	2.2	5.3	2.3	-0.5	1.0
Total zone transitions, hab. session 1	1.7	2.4	4.1	-0.3	-1.7	2.0
Total locomotion distance, hab. session 1	3.8	5.4	7.8	-0.9	-2.7	2.8
Locomotion velocity, hab. session 1	3.0	4.2	6.1	-1.1	-2.3	2.5
Time in familiar zone, hab. session 2	2.3	2.6	7.2	-2.7	0.1	-0.8
Time in novel zone, hab. session 2	2.8	3.1	8.0	2.8	-0.3	1.0
Total zone transitions, hab. session 2	2.7	3.5	6.3	1.3	-1.5	2.5
Total locomotion distance, hab. session 2	1.5	1.9	3.5	-0.3	-1.5	1.9
Locomotion velocity, hab. session 2	2.1	2.8	5.1	-0.3	-1.8	2.3
Novel to familiar place preference ratio	1.6	2.1	4.6	2.1	-0.7	1.1
Novelty place preference	1.3	1.7	3.3	1.8	-0.8	1.1
Time in novel zone, NPP test	1.5	1.8	4.1	2.0	-0.6	1.0
Total zone transitions, NPP test	0.8	1.2	2.1	0.9	-0.8	1.4
Total locomotion distance, NPP test	1.2	1.6	3.1	0.5	-1.2	1.8
Locomotion velocity, NPP test	1.1	1.5	2.8	0.1	-1.3	1.7
Intraocular pressure	1.0	1.6	2.2	-1.1	1.1	-1.5
Delta distance traveled before/after self-admin	0.3	0.3	0.4	0.6	0.6	-0.4
Delta ambulatory time before/after self-admin	0.1	0.2	0.7	0.8	0.1	0.1
Parametrial fat weight	0.1	0.3	0.8	0.9	0.1	0.1
Pavlov. Cond. lever latency	1.4	1.7	2.9	-0.3	1.5	-1.7
Pavlov. Cond. magazine entry latency	0.5	0.7	1.7	-1.3	-0.5	0.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.6	0.0	-0.1
Pavlov. Cond. index score	0.6	0.7	1.0	-0.5	-1.0	1.0
Pavlov. Cond. latency score	1.0	1.3	1.8	-0.4	-1.3	1.3
Pavlov. Cond. lever contacts	1.2	1.4	2.4	0.5	-1.3	1.5
Pavlov. Cond. magazine entry number	0.2	0.3	0.8	0.9	0.2	0.1
Pavlov. Cond. intertrial magazine entries	0.8	0.9	1.7	-0.5	0.9	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.9	-0.5	-0.9	0.8
Pavlov. Cond. response bias	0.2	0.2	0.6	-0.7	-0.3	0.0
Pavlov. Cond. lever latency	0.7	0.9	2.3	1.5	0.7	-0.2
Pavlov. Cond. magazine entry latency	0.8	1.1	2.6	-1.6	-0.9	0.2
Pavlov. Cond. change in total contacts	0.1	0.3	0.9	-0.9	-0.2	-0.3
Pavlov. Cond. index score	0.6	1.0	2.5	-1.6	-0.6	-0.1
Pavlov. Cond. latency score	0.7	1.2	2.7	-1.6	-0.8	0.2
Pavlov. Cond. lever contacts	0.6	0.8	2.3	-1.5	-0.3	-0.2
Pavlov. Cond. magazine entry number	0.9	1.1	2.5	1.6	0.9	-0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.8	1.1	0.9	1.1	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.1	2.7	-1.6	-0.8	0.1
Pavlov. Cond. response bias	0.9	1.2	3.4	-1.8	-0.4	-0.4
Time in closed arm before self-admin	0.5	0.8	1.2	0.5	-1.0	1.1
Time in closed arm after self-admin	0.3	0.3	0.6	0.8	0.5	-0.3
Time in open arm before self-admin	0.0	0.0	0.0	0.0	0.2	-0.1
Time in open arm after self-admin	0.8	0.8	1.1	1.0	1.0	-0.7
Bone: periosteal estimation	1.0	2.3	3.9	2.0	-1.1	1.3
Bone: periosteal perimeter	1.0	1.9	2.9	0.7	-1.6	1.7
Bone: post-yield work	0.2	0.4	0.8	0.9	0.3	-0.6
Progressive ratio test 1 active lever presses	0.3	0.5	0.9	1.0	0.6	-0.4
Progressive ratio test 1 breakpoint	0.3	0.5	0.9	0.9	0.6	-0.4
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.2	-0.1	0.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.3	-0.1	0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.2	-0.2	0.1
Progressive ratio test 2 inactive lever presses	0.2	0.6	1.1	1.1	-0.5	0.6
Incentive Sensitization - Responses	0.0	0.1	0.2	-0.5	-0.2	-0.0
Incentive Sensitization - Breakpoint	0.1	0.2	0.4	-0.6	-0.4	0.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.4	0.0	-0.1
Progressive ratio	0.3	1.0	1.2	1.0	1.1	-0.9
Food seeking constrained by brief footshock	0.9	1.1	3.2	-1.8	-0.5	0.0
Seeking ratio, punishment vs. effort	0.7	1.5	3.5	-1.9	-0.9	0.5
Retroperitoneal fat weight	1.3	5.6	7.2	2.3	2.7	-2.1
Reaction time number correct	0.5	1.6	2.2	0.7	1.5	-1.5
Reaction time mean minus median	0.1	0.9	2.1	-1.4	-0.7	0.4
Reaction time mean minus median AUC	0.4	2.4	3.8	-1.1	-1.9	1.5
Reaction time num false alarms	0.3	0.4	0.7	0.8	0.6	-0.5
Reaction time num false alarms AUC	0.3	0.6	0.8	0.7	0.9	-0.7
Reaction time trials correct on left	0.5	1.6	2.2	0.7	1.5	-1.5
Reaction time trials on left	0.4	1.5	2.0	0.7	1.4	-1.4
Reaction time mean	0.7	1.6	2.1	-1.0	-1.5	1.3
Reaction time mean AUC	0.5	1.1	1.6	-0.5	-1.2	1.2
Median of all reaction times	0.8	1.2	1.7	-0.6	-1.3	1.2
Reaction time omissions	0.2	0.3	0.5	0.2	-0.7	0.7
Reaction time false alarm rate	0.1	0.1	0.2	0.4	-0.1	0.3
Reaction time premature initiation rate	0.8	1.2	2.9	-1.7	0.4	-0.8
Reaction time premature initiations	0.7	2.0	2.7	-1.3	1.3	-1.6
Std. dev. reaction times	0.3	0.9	1.2	-0.9	-1.1	0.9
Reaction time trials completed	0.4	1.5	2.0	0.7	1.4	-1.4
Reaction time trials AUC	0.6	1.9	2.7	0.7	1.6	-1.6
Run reversals in cocaine runway, females	1.6	1.8	2.4	-1.6	-1.5	0.9
Run reversals in cocaine runway, males	1.6	1.7	2.3	-1.3	-1.5	1.2
Latency to leave start box in cocaine runway	1.0	1.4	2.0	0.9	-1.2	1.4
Latency to leave start box in cocaine runway, F	1.9	2.4	3.6	1.0	-1.7	1.9
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	0.1	0.5	-0.5
Std. dev. time between licks in bursts	0.7	1.2	1.8	-0.5	-1.4	1.3
Total sessions with >9 infusions	0.5	0.6	1.7	1.3	-0.1	0.3
Short access day 1 total inactive lever presses	0.2	0.4	0.7	-0.8	0.3	-0.5
Short access day 10 total inactive lever presses	0.3	1.9	2.5	-1.1	1.4	-1.6
Short access day 1 total infusions	0.3	0.5	1.5	1.2	0.0	0.3
Short access day 10 total infusions	0.1	0.1	0.2	0.5	0.3	-0.2
Short access total infusions	0.6	0.9	2.4	1.6	-0.0	0.4
Short access day 1 locomotion	0.1	0.1	0.2	-0.5	0.2	-0.4
Short access day 10 total locomotion	0.5	2.0	3.5	-1.9	0.9	-1.3
Short access total locomotion	0.1	0.2	0.2	-0.5	0.4	-0.5
One hour access (0.3 mA shock)	0.3	0.3	0.5	0.7	0.5	-0.4
Compulsive drug intake	0.1	0.1	0.2	-0.0	-0.4	0.4
One hour access (shock baseline)	0.0	0.1	0.1	0.1	0.3	-0.3
Social response proportion	0.7	0.9	1.5	-1.2	-0.9	0.5
Social responses	5.0	6.6	12.4	-3.5	-2.3	1.4
Social time	0.5	0.8	1.0	0.9	1.0	-0.7
Soleus weight	2.5	7.3	18.3	4.3	1.8	-0.3
Bone: stiffness	1.5	2.7	7.9	2.8	0.1	0.1
Tibialis anterior weight	0.5	1.8	4.4	2.1	1.0	-0.1
Time to tail flick, vehicle, before self-admin	1.0	1.3	1.8	-0.8	-1.3	1.2
Time to tail flick, vehicle, after self-admin	0.7	1.5	1.8	-1.3	1.0	-1.3
Time to tail flick, test, before self-admin	1.2	1.3	2.1	-0.3	-1.4	1.3
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.2	-0.5	0.6
Delta time to tail flick, vehicle, before/after SA	2.0	2.2	3.4	0.2	1.9	-1.7
Delta time to tail flick, test, before/after SA	0.8	1.0	1.5	-0.4	1.2	-1.2
Tibia length	0.5	1.3	3.8	-1.9	-0.2	-0.3
Ambulatory time before self-admin	0.1	0.2	0.5	-0.7	-0.3	0.1
Ambulatory time after self-admin	0.0	0.0	0.0	-0.1	-0.1	0.1
Bone: tissue strength	2.4	2.5	7.2	2.7	0.4	0.2
Total heroin consumption	1.3	1.5	2.6	-1.6	-1.2	0.8
Bone: trabecular number	1.3	2.5	4.1	-0.3	-1.8	2.0
Bone: trabecular spacing	2.9	4.2	6.7	-0.2	2.4	-2.6
Bone: trabecular thickness	5.3	7.3	11.1	1.3	-3.1	3.3
Bone: trabecular tissue density	2.4	4.2	6.6	2.6	1.9	-1.6
Water consumed over 24 hours	0.4	0.8	1.2	1.1	-0.6	0.9
Number of responses in last shaping day	0.5	0.7	1.9	-1.4	0.1	-0.5