Hub : Genes

Ankfy1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Ankfy1 0.04 0.03 3.8e-04 0.02 0.03 0.03 0.02 4.7e-03 7.2e-04 8.3e-04 1.9e-03
2 BLA gene expression Ankfy1 0.11 0.08 7.1e-05 0.06 0.07 0.06 0.07 2.3e-04 1.0e-04 2.5e-04 8.5e-05
3 Adipose gene expression Ankfy1 0.12 0.07 2.5e-10 0.06 0.07 0.08 0.07 1.5e-07 2.4e-08 3.9e-09 2.2e-08
4 Liver gene expression Ankfy1 0.03 0.02 7.5e-03 0.01 0.01 0 0.01 9.0e-03 2.7e-02 9.5e-02 2.3e-02
5 IL gene expression Ankfy1 0.25 0.15 1.5e-03 0.01 0.01 -0.01 0.01 1.4e-01 2.3e-01 6.2e-01 2.1e-01
6 LHb gene expression Ankfy1 0.22 0.14 5.7e-03 0.09 0.06 0.08 0.07 3.8e-03 1.8e-02 6.2e-03 1.0e-02
7 PL gene expression Ankfy1 0.07 0.05 1.0e-06 0.06 0.05 0.05 0.06 2.1e-07 2.2e-06 3.7e-06 7.2e-07
8 Liver mRNA stability Ankfy1 0.07 0.05 1.2e-05 0.03 0.03 0.03 0.03 1.2e-04 4.0e-04 3.4e-04 2.0e-04
9 pVTA gene expression Ankfy1 0.15 0.09 1.4e-06 0.16 0.09 0.15 0.04 1.2e-07 1.6e-04 5.2e-07 6.6e-03
10 Brain gene expression Ankfy1 0.08 0.06 2.3e-07 0.08 0.07 0.07 0.07 9.6e-08 4.9e-07 7.2e-07 3.2e-07
11 Adipose mRNA stability Ankfy1 0.13 0.09 1.9e-12 0.09 0.09 0.11 0.09 6.2e-10 2.8e-10 3.5e-12 2.3e-10
12 BLA alternative TSS XM_039086000.1 0.08 0.06 7.8e-03 0.01 0.02 0.02 0.02 5.1e-02 2.3e-02 1.9e-02 4.0e-02
13 BLA alternative TSS XM_039086000.1 0.08 0.06 7.3e-03 0.02 0.02 0.03 0.02 3.8e-02 2.1e-02 1.7e-02 2.6e-02
14 BLA alternative TSS NM_001107018.2 0.08 0.07 6.3e-03 0.01 0.03 0.02 0.01 1.0e-01 1.5e-02 1.9e-02 5.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.40.72.00.00.40.40.7-0.7-0.7-0.70.60.70.71.1-1.3-1.4-1.3
Area under the delay curve0.10.10.10.2-0.20.0-0.40.40.40.4-0.3-0.1-0.1-0.20.30.40.3
BMI with tail0.20.71.00.8-0.70.9-0.50.60.60.6-0.61.00.91.0-1.0-1.0-1.0
BMI without tail0.40.81.70.9-0.61.1-0.60.40.40.4-0.51.01.01.3-1.2-1.2-1.3
Body weight0.52.26.30.40.31.10.6-0.7-0.7-0.70.71.51.52.1-2.4-2.5-2.4
Weight adjusted by age2.93.24.12.0-1.72.0-1.71.81.81.8-1.61.91.91.8-1.7-1.6-1.7
Bone surface0.91.52.71.2-0.91.4-0.60.70.70.7-0.71.51.51.6-1.6-1.6-1.6
Bone volume1.22.13.41.4-1.11.7-0.90.90.90.9-0.91.81.81.8-1.8-1.8-1.8
Breakpoint value in progressive ratio session0.50.51.60.40.20.70.1-0.0-0.0-0.00.30.60.61.2-1.1-1.2-1.3
Number of licking bursts0.20.30.4-0.50.4-0.60.3-0.4-0.4-0.40.3-0.6-0.6-0.60.60.60.6
Context. condit. distance diff. score1.01.22.31.0-0.71.2-0.50.50.50.5-0.51.41.41.4-1.5-1.5-1.5
Locomotion velocity, session 11.71.84.71.0-0.31.4-0.20.20.20.20.01.61.62.0-2.1-2.2-2.1
Locomotion distance, session 10.81.11.51.2-0.91.2-0.90.90.90.9-0.81.11.11.2-1.0-1.0-1.1
Locomotion velocity, session 20.40.51.1-0.70.9-0.51.0-1.0-1.0-1.01.0-0.3-0.3-0.0-0.2-0.3-0.2
Locomotion distance, session 20.20.30.80.20.10.40.2-0.2-0.2-0.20.30.50.50.8-0.8-0.9-0.8
Locomotion velocity, session 31.82.13.3-1.51.2-1.71.0-1.0-1.0-1.01.0-1.7-1.7-1.81.71.71.8
Locomotion distance, session 30.10.10.2-0.40.3-0.50.4-0.4-0.4-0.40.3-0.4-0.4-0.40.30.30.4
Stereotopy head waving bouts, day 30.00.00.0-0.20.2-0.10.2-0.2-0.2-0.20.2-0.0-0.0-0.0-0.1-0.1-0.0
Stereotopy head waving duration, day 30.50.61.20.6-0.90.2-1.11.11.11.1-1.0-0.0-0.0-0.30.60.70.6
Locomotion velocity, session 70.10.10.10.3-0.30.2-0.30.30.30.3-0.30.20.20.2-0.2-0.1-0.1
Locomotion distance, session 70.00.00.0-0.20.1-0.10.2-0.2-0.2-0.20.1-0.0-0.0-0.1-0.0-0.00.0
Stereotopy head waving bouts, day 71.01.11.61.1-0.91.2-0.70.70.70.7-0.71.31.31.2-1.3-1.2-1.2
Stereotopy head waving duration, day 71.11.42.21.2-0.91.4-0.80.70.70.7-0.71.41.41.4-1.5-1.5-1.4
Locomotion velocity, session 81.01.21.61.1-1.01.2-0.80.80.80.8-0.91.31.31.2-1.2-1.2-1.1
Locomotion distance, session 81.31.84.61.0-0.51.4-0.20.20.20.2-0.21.71.71.9-2.1-2.2-2.0
Degree of sensitization distance0.60.60.90.8-0.60.9-0.60.60.60.6-0.60.90.90.9-0.9-0.8-0.9
Degree of sensitization stereotypy1.01.12.50.8-0.51.2-0.30.20.20.2-0.31.31.31.5-1.6-1.6-1.5
Conditioned locomotion0.70.81.7-0.70.4-1.00.3-0.3-0.3-0.30.2-1.1-1.1-1.21.31.31.3
Cocaine response after cond. corrected0.70.81.6-1.01.2-0.71.2-1.2-1.2-1.21.3-0.6-0.6-0.30.1-0.00.1
Cocaine response after cond. not corrected0.40.40.9-0.60.9-0.40.9-0.8-0.8-0.81.0-0.3-0.30.1-0.3-0.4-0.2
Cocaine response before conditioning0.80.91.31.1-0.91.1-0.90.80.80.8-0.81.01.01.1-1.0-1.0-1.0
Saline control response0.40.60.80.8-0.60.9-0.70.70.70.7-0.50.80.80.9-0.8-0.8-0.8
Bone: connectivity density0.71.13.00.5-0.00.90.2-0.2-0.2-0.20.21.21.21.5-1.7-1.7-1.6
Bone: cortical apparent density1.01.42.3-1.10.9-1.30.7-0.7-0.7-0.70.8-1.4-1.4-1.51.51.51.4
Bone: cortical area0.20.30.80.0-0.3-0.2-0.50.50.50.5-0.4-0.4-0.4-0.60.80.90.7
Bone: cortical porosity1.81.93.4-1.61.8-1.31.8-1.8-1.8-1.81.8-1.0-1.0-0.70.30.20.4
Bone: cortical porosity1.61.82.9-1.61.7-1.31.7-1.7-1.7-1.71.7-1.1-1.1-0.80.50.40.5
Bone: cortical thickness2.03.34.6-1.91.6-2.11.3-1.3-1.3-1.31.4-2.1-2.1-2.12.12.12.0
Bone: cortical thickness4.24.96.5-2.52.5-2.42.4-2.4-2.4-2.42.5-2.2-2.2-1.81.61.51.5
Bone: cortical tissue density0.91.11.8-1.10.9-1.20.7-0.7-0.7-0.70.7-1.3-1.3-1.31.41.31.3
Condit. Reinf. active minus inactive responses1.21.32.3-1.31.5-1.11.4-1.5-1.5-1.51.5-0.9-0.9-0.60.40.30.4
Condit. Reinf. active-inactive response ratio0.70.81.4-1.01.2-0.91.1-1.1-1.1-1.11.2-0.8-0.8-0.50.40.30.3
Condit. Reinf. active responses0.81.01.9-1.11.3-0.91.3-1.3-1.3-1.31.4-0.8-0.8-0.50.30.20.3
Condit. Reinf. inactive responses0.00.00.1-0.20.2-0.20.2-0.2-0.2-0.20.2-0.2-0.2-0.20.20.20.2
Incentive salience index mean1.62.03.8-1.61.9-1.21.8-1.9-1.9-1.91.9-1.0-1.0-0.60.30.20.3
Condit. Reinf. lever presses2.02.75.7-1.72.2-1.22.3-2.3-2.3-2.32.4-0.8-0.8-0.2-0.2-0.3-0.2
Condit. Reinf. active minus inactive responses0.60.81.5-1.01.0-0.81.2-1.2-1.2-1.21.1-0.6-0.6-0.40.10.10.2
Condit. Reinf. active-inactive response ratio0.91.01.5-1.21.2-1.01.2-1.2-1.2-1.21.2-0.9-0.9-0.70.50.40.5
Condit. Reinf. active responses0.20.30.7-0.70.7-0.50.8-0.9-0.9-0.90.7-0.3-0.3-0.20.0-0.00.1
Condit. Reinf. inactive responses0.10.20.40.4-0.60.3-0.50.40.40.4-0.70.40.40.1-0.1-0.1-0.0
Condit. Reinf. lever presses0.30.30.9-0.40.0-0.6-0.0-0.1-0.1-0.1-0.1-0.7-0.7-0.90.91.00.9
Condit. Reinf. lever reinforcers received0.20.20.5-0.60.5-0.50.6-0.7-0.7-0.70.5-0.3-0.3-0.30.10.10.2
Conditioned reinforcement - actives1.01.01.51.0-1.01.0-0.90.80.80.8-0.91.21.21.0-1.1-1.0-0.9
Conditioned reinforcement - inactives1.82.12.91.6-1.51.7-1.71.61.61.6-1.41.41.31.3-1.1-1.0-1.1
Conditioned locomotion0.70.82.00.9-1.30.7-1.31.11.11.1-1.40.50.60.1-0.00.10.1
Patch foraging indifference point 0 sec1.72.74.6-1.92.1-1.61.9-1.7-1.7-1.72.1-1.7-1.7-1.11.00.90.8
Patch foraging indifference point AUC1.92.24.71.7-1.61.3-2.12.22.22.2-1.70.70.80.6-0.10.0-0.2
Delay disc. indifference point, 0s delay2.02.23.01.7-1.51.7-1.51.51.51.5-1.41.51.51.5-1.3-1.2-1.3
Delay disc. indifference point, 16s delay0.50.51.00.8-0.90.6-1.01.01.01.0-0.90.40.40.20.00.1-0.0
Delay disc. indifference point, 2s delay0.10.20.3-0.30.2-0.40.2-0.2-0.2-0.20.1-0.5-0.5-0.50.60.60.6
Delay disc. indifference point, 24s delay0.90.81.1-1.01.0-1.00.8-0.8-0.8-0.80.9-1.0-1.0-0.90.90.80.8
Delay disc. indifference point, 4s delay0.50.50.70.8-0.80.8-0.80.80.80.8-0.70.70.70.6-0.5-0.4-0.5
Delay disc. indifference point, 8s delay0.00.00.00.1-0.10.0-0.10.10.10.1-0.10.00.0-0.00.10.10.1
Indifference point function ln k6.08.412.9-3.43.4-3.13.5-3.6-3.6-3.63.4-2.4-2.5-2.11.51.31.5
Indifference point function log k6.08.412.9-3.43.4-3.13.5-3.6-3.6-3.63.4-2.4-2.5-2.11.51.31.5
Patch foraging total patch changes 0 sec1.11.83.2-1.51.8-1.31.5-1.4-1.4-1.41.8-1.4-1.4-0.90.90.70.7
Patch foraging total patch changes 12 sec1.01.32.31.3-1.21.3-1.41.51.51.5-1.20.90.90.9-0.5-0.5-0.7
Patch foraging total patch changes 18 sec0.40.51.10.9-0.50.9-1.01.01.01.0-0.50.40.50.7-0.3-0.2-0.5
Patch foraging total patch changes 24 sec0.40.51.50.7-0.60.6-1.11.21.21.2-0.70.00.10.20.30.40.1
Patch foraging total patch changes 6 sec1.21.84.41.5-1.31.3-1.92.12.12.1-1.30.60.60.7-0.10.0-0.3
Patch foraging time to switch 0 sec1.52.33.21.7-1.61.8-1.41.31.31.3-1.51.71.71.5-1.4-1.4-1.4
Patch foraging water rate 0 sec0.71.11.6-1.10.9-1.30.8-0.7-0.7-0.70.8-1.1-1.1-1.31.21.21.2
Patch foraging water rate 12 sec0.30.41.00.4-0.30.6-0.10.10.10.1-0.20.90.90.8-1.0-0.9-0.9
Patch foraging water rate 18 sec0.60.82.1-0.91.0-0.61.4-1.2-1.2-1.21.2-0.1-0.10.0-0.4-0.5-0.4
Patch foraging water rate 24 sec0.10.10.40.2-0.60.1-0.10.10.10.1-0.60.60.5-0.1-0.3-0.1-0.0
Patch foraging water rate 6 sec0.20.30.6-0.60.3-0.70.5-0.6-0.6-0.60.3-0.3-0.3-0.80.50.60.7
Seeking ratio, delayed vs. immediate footshock0.50.61.3-0.60.6-0.80.4-0.1-0.1-0.10.5-1.0-1.0-1.01.11.11.0
Distance traveled before self-admin0.70.71.80.8-1.00.5-1.21.31.31.3-1.10.10.1-0.10.40.50.3
Distance traveled after self-admin6.67.39.63.1-3.13.0-3.03.03.03.0-3.02.72.62.2-1.8-1.7-1.8
Extensor digitorum longus weight3.614.118.04.1-3.74.2-3.43.53.53.5-3.44.24.23.9-3.7-3.5-3.5
Bone: elastic displacement0.30.30.9-0.20.0-0.5-0.20.20.20.2-0.1-0.6-0.6-0.70.90.90.9
Bone: elastic work1.11.42.9-1.10.8-1.30.5-0.5-0.5-0.50.6-1.5-1.5-1.51.71.71.6
Bone: endosteal estimation3.16.89.63.0-3.12.8-3.13.13.13.1-3.12.32.32.0-1.5-1.3-1.5
Bone: endosteal perimeter3.36.89.43.0-3.12.8-3.03.03.03.0-3.02.42.42.1-1.6-1.5-1.6
Epididymis fat weight3.27.312.32.8-2.13.2-1.81.81.81.8-1.83.13.13.5-3.3-3.3-3.4
Delta time in closed arm before/after self-admin1.01.01.71.2-0.81.1-1.21.31.31.3-0.80.70.70.9-0.5-0.5-0.6
Delta time in open arm before/after self-admin0.80.81.20.9-0.91.0-0.60.70.70.7-0.81.01.10.9-1.0-0.9-0.9
Diff in mean of infusions in LGA sessions0.50.51.2-0.50.8-0.21.1-1.1-1.1-1.10.9-0.00.00.4-0.6-0.7-0.6
Delay discount exponential model param0.10.10.20.1-0.10.20.0-0.0-0.0-0.0-0.00.30.30.3-0.4-0.4-0.3
Extinction: sum of active levers before priming1.11.12.80.7-0.21.1-0.0-0.0-0.0-0.00.11.21.11.5-1.6-1.7-1.6
Active lever presses in extinction session 61.11.12.11.1-0.61.3-0.70.70.70.7-0.51.11.11.4-1.3-1.3-1.4
Bone: final force0.60.91.21.1-1.01.1-1.01.01.01.0-1.01.01.00.9-0.7-0.7-0.8
Bone: final moment0.61.01.31.2-1.11.1-1.11.11.11.1-1.11.01.00.9-0.6-0.6-0.7
Food consumed during 24 hour testing period0.60.71.3-1.01.0-0.81.1-1.2-1.2-1.21.0-0.6-0.6-0.40.30.20.2
Glucose0.81.23.30.0-0.6-0.5-0.90.90.90.9-0.9-0.9-0.9-1.31.71.81.6
Heart weight0.91.31.81.3-1.01.4-0.91.11.11.1-0.91.21.21.3-1.1-1.1-1.2
Delay discount hyperbolic model param0.00.00.10.00.00.10.1-0.1-0.1-0.10.10.20.20.2-0.3-0.3-0.3
Intermittent access intake day 1-15 change1.31.33.11.2-1.50.8-1.81.61.61.6-1.60.50.50.00.40.50.3
Intermittent access intake escalation1.21.22.81.0-1.30.6-1.71.51.51.5-1.50.30.4-0.20.50.70.6
Intermittent access intake escalation 20.80.71.60.3-0.7-0.2-0.90.90.90.9-0.9-0.3-0.3-0.91.11.31.2
Intermitt. access day 1 inactive lever presses0.30.41.0-0.1-0.5-0.2-0.50.30.30.3-0.6-0.4-0.5-0.91.01.01.0
Intermitt. access day 15 inactive lever presses0.20.20.4-0.50.6-0.40.5-0.6-0.6-0.60.6-0.3-0.3-0.30.20.10.2
Intermitt. access escalation Index0.90.82.30.30.10.70.3-0.5-0.5-0.50.30.80.81.3-1.4-1.5-1.5
Intermittent access day 1 total infusions2.12.53.31.7-1.71.8-1.51.41.41.4-1.61.71.61.6-1.5-1.5-1.5
Intermittent access day 15 total infusions5.25.99.62.8-3.12.6-3.12.92.92.9-3.12.12.11.6-1.2-1.0-1.1
Intermittent access terminal intake (last 3 days)4.34.76.32.5-2.52.4-2.32.22.22.2-2.42.22.22.0-1.7-1.6-1.6
Intermittent access total infusions2.83.25.02.0-2.21.9-2.11.81.81.8-2.21.81.71.4-1.2-1.1-1.1
Intermittent access day 1 locomotion2.42.54.11.7-2.01.8-1.81.41.41.4-2.01.81.71.2-1.3-1.1-1.1
Intermittent access day 15 total locomotion1.81.93.81.5-1.91.3-1.81.81.81.8-2.01.11.00.5-0.4-0.2-0.3
Intermittent access total locomotion1.11.32.81.2-1.71.2-1.40.90.90.9-1.71.31.20.6-0.8-0.6-0.5
Intermittent access standard deviation4.44.79.32.4-2.91.9-3.02.92.92.9-3.01.51.40.7-0.2-0.0-0.1
Left kidney weight0.10.40.90.7-0.60.6-0.90.90.90.9-0.70.20.20.30.10.1-0.1
Right kidney weight0.10.20.60.5-0.40.4-0.60.80.80.8-0.50.10.10.20.20.2-0.0
Cocaine induced anxiety2.12.43.0-1.71.3-1.71.2-1.7-1.7-1.71.2-1.5-1.5-1.71.41.41.6
Post-drug Anxiety0.91.01.6-1.11.1-1.01.1-1.3-1.3-1.31.1-0.9-0.9-0.80.50.50.6
Baseline Anxiety0.80.91.31.1-0.71.0-0.61.11.11.1-0.60.90.91.1-0.9-0.9-1.0
Tail length1.13.29.20.70.31.50.5-0.7-0.7-0.70.71.81.82.7-2.9-3.0-3.0
Length with tail0.62.15.20.00.90.71.1-1.2-1.2-1.21.31.01.11.9-2.1-2.3-2.2
Length without tail0.51.02.90.20.30.70.6-0.4-0.4-0.40.61.01.11.4-1.7-1.7-1.6
Times rat made contact with spout1.31.52.1-1.41.4-1.31.3-1.3-1.3-1.31.4-1.3-1.3-1.00.80.80.8
Lifetime Intake4.24.77.12.5-2.72.4-2.52.32.32.3-2.62.22.11.7-1.6-1.4-1.4
Liver weight, left0.20.40.8-0.40.6-0.10.8-0.9-0.9-0.90.70.20.30.4-0.6-0.7-0.7
Liver weight, right0.71.12.30.9-0.61.2-0.30.30.30.3-0.41.31.31.4-1.5-1.5-1.5
Locomotor activity0.61.01.41.1-1.01.2-0.90.80.80.8-0.91.21.21.0-1.0-0.9-0.9
Locomotor testing distance3.15.26.72.6-2.62.5-2.52.32.32.3-2.42.42.52.0-1.8-1.6-1.7
Locomotor testing rearing3.75.77.82.8-2.72.6-2.82.82.82.8-2.62.22.31.9-1.5-1.3-1.5
Locomotion in novel chamber1.31.63.90.9-1.70.3-1.41.71.71.7-2.00.20.3-0.80.91.11.1
Locomotion in novel chamber post-restriction0.30.30.6-0.60.4-0.60.4-0.4-0.4-0.40.3-0.7-0.7-0.80.80.70.7
Fecal boli incidents, locomotor time 10.40.40.5-0.70.7-0.60.6-0.6-0.6-0.60.7-0.7-0.6-0.60.50.50.5
Change in fecal boli incidents, locomotor task0.60.60.8-0.90.8-0.90.7-0.8-0.8-0.80.7-0.8-0.8-0.70.60.60.6
Time >=10cm from walls, locomotor time 10.40.40.6-0.70.7-0.70.7-0.7-0.7-0.70.7-0.6-0.7-0.50.50.40.4
Bouts of movement, locomotor time 10.70.81.5-1.01.1-0.91.1-1.2-1.2-1.21.1-0.8-0.7-0.50.30.20.3
Total resting periods, locomotor time 12.02.23.2-1.71.7-1.61.6-1.8-1.8-1.81.7-1.4-1.4-1.00.80.70.8
Rest time, locomotor task time 10.50.60.9-0.80.6-0.90.5-0.5-0.5-0.50.5-0.9-1.0-1.01.00.91.0
Distance moved, locomotor task time 11.11.21.61.3-1.11.2-1.11.21.21.2-1.01.21.21.1-0.9-0.9-1.0
Vertical activity count, locomotor time 11.11.11.51.2-1.11.2-0.90.90.90.9-1.01.21.21.2-1.1-1.1-1.1
Time >=10cm from walls, locomotor time 20.80.91.1-1.00.9-1.00.9-1.0-1.0-1.00.9-0.9-1.0-0.80.80.70.7
Bouts of movement, locomotor time 21.31.42.1-1.41.3-1.31.2-1.4-1.4-1.41.3-1.2-1.2-1.00.80.70.8
Total resting periods, locomotor time 20.91.01.6-1.11.1-1.01.1-1.3-1.3-1.31.1-0.9-0.9-0.70.50.50.5
Rest time, locomotor task time 21.01.11.7-1.21.0-1.31.0-1.0-1.0-1.01.0-1.1-1.1-1.11.01.01.0
Distance moved, locomotor task time 22.02.33.41.8-1.81.6-1.71.81.81.8-1.71.41.41.2-0.9-0.8-0.9
Vertical activity count, locomotor time 20.70.71.01.0-1.01.0-0.90.80.80.8-0.90.90.90.8-0.7-0.7-0.7
Light reinforcement 11.32.43.21.8-1.71.8-1.61.61.61.6-1.61.61.61.5-1.2-1.1-1.2
Light reinforcement 20.20.20.50.5-0.70.4-0.60.50.50.5-0.70.30.30.2-0.00.00.0
Bone: marrow area3.16.69.43.0-3.12.7-3.13.03.03.0-3.02.32.32.0-1.5-1.3-1.5
Bone: maximum diameter0.81.42.71.3-1.51.1-1.61.61.61.6-1.60.70.70.5-0.10.0-0.2
Bone: maximum force0.61.11.51.2-1.21.1-1.21.21.21.2-1.21.01.00.9-0.7-0.6-0.7
Bone: maximum moment0.81.32.01.3-1.41.2-1.41.41.41.4-1.41.01.00.9-0.6-0.5-0.6
Mean time between licks in bursts1.42.03.51.4-1.11.6-0.70.80.80.8-0.91.81.81.8-1.9-1.9-1.7
Mean num. licks in bursts0.10.10.2-0.30.4-0.20.4-0.4-0.4-0.40.5-0.1-0.10.1-0.1-0.2-0.2
Cd content in liver1.11.21.81.2-1.01.3-0.90.90.90.9-0.91.31.21.2-1.1-1.1-1.2
Co content in liver0.20.20.40.5-0.40.5-0.30.30.30.3-0.30.60.60.5-0.5-0.5-0.5
Cu content in liver2.83.44.5-2.12.1-2.02.0-2.0-2.0-2.02.0-1.8-1.9-1.61.41.31.3
Fe content in liver0.30.30.6-0.30.6-0.00.8-0.8-0.8-0.80.80.20.20.4-0.5-0.6-0.6
K content in liver0.30.30.5-0.20.50.00.6-0.6-0.6-0.60.60.20.20.5-0.7-0.7-0.6
Mg content in liver0.00.00.00.1-0.10.0-0.20.20.20.2-0.2-0.1-0.1-0.10.10.10.1
Mn content in liver1.51.72.6-1.51.6-1.41.6-1.6-1.6-1.61.6-1.2-1.2-0.90.60.50.6
Na content in liver0.10.10.30.3-0.40.1-0.50.50.50.5-0.5-0.1-0.1-0.20.30.30.3
Rb content in liver0.81.01.31.1-1.11.1-1.01.01.01.0-1.01.01.00.9-0.8-0.7-0.8
Se content in liver1.01.21.9-1.10.9-1.30.8-0.8-0.8-0.80.8-1.3-1.3-1.31.41.31.3
Sr content in liver1.81.72.21.4-1.21.4-1.11.11.11.1-1.11.51.51.4-1.4-1.4-1.3
Zn content in liver0.20.20.3-0.40.3-0.50.3-0.3-0.3-0.30.3-0.5-0.5-0.50.50.50.5
Bone: minimum diameter2.03.85.12.2-2.32.1-2.22.22.22.2-2.21.91.91.6-1.3-1.2-1.3
Time in familiar zone, hab. session 10.20.20.30.4-0.50.2-0.60.60.60.6-0.60.10.1-0.00.10.20.2
Time in novel zone, hab. session 10.40.30.7-0.70.7-0.50.8-0.8-0.8-0.80.8-0.3-0.3-0.20.0-0.00.0
Total zone transitions, hab. session 14.76.68.93.0-2.92.8-2.82.82.82.8-2.82.62.62.3-1.9-1.8-1.9
Total locomotion distance, hab. session 10.30.40.60.7-0.60.8-0.60.60.60.6-0.60.70.70.7-0.7-0.6-0.7
Locomotion velocity, hab. session 10.40.60.80.9-0.80.8-0.80.80.80.8-0.80.80.80.7-0.6-0.6-0.6
Time in familiar zone, hab. session 20.20.20.4-0.50.6-0.30.6-0.6-0.6-0.60.6-0.2-0.2-0.0-0.1-0.1-0.1
Time in novel zone, hab. session 20.30.30.6-0.40.2-0.60.1-0.1-0.1-0.10.1-0.6-0.6-0.80.70.80.8
Total zone transitions, hab. session 22.33.04.12.0-1.62.0-1.61.61.61.6-1.51.91.91.9-1.7-1.6-1.7
Total locomotion distance, hab. session 20.40.50.70.8-0.60.9-0.70.60.60.6-0.60.80.80.9-0.7-0.7-0.8
Locomotion velocity, hab. session 20.50.60.90.9-0.70.9-0.80.70.70.7-0.70.80.80.9-0.7-0.7-0.8
Novel to familiar place preference ratio0.10.10.20.3-0.40.1-0.40.40.40.4-0.50.00.0-0.10.20.20.2
Novelty place preference0.00.00.00.0-0.10.0-0.10.10.10.1-0.10.00.0-0.10.00.00.1
Time in novel zone, NPP test0.00.00.0-0.00.0-0.00.1-0.1-0.1-0.10.00.10.10.0-0.1-0.1-0.0
Total zone transitions, NPP test3.04.35.82.4-2.12.4-2.22.12.12.1-2.02.12.12.1-1.7-1.6-1.8
Total locomotion distance, NPP test0.30.40.90.7-0.80.5-0.90.90.90.9-0.80.30.30.20.00.1-0.0
Locomotion velocity, NPP test0.30.40.90.6-0.70.3-1.00.90.90.9-0.8-0.0-0.0-0.20.50.50.4
Intraocular pressure1.42.03.91.6-1.81.1-1.82.02.02.0-1.80.90.90.6-0.10.0-0.1
Delta distance traveled before/after self-admin3.63.96.02.1-1.92.3-1.61.31.31.3-1.62.52.42.2-2.3-2.2-2.2
Delta ambulatory time before/after self-admin2.32.54.11.6-1.51.8-1.21.01.01.0-1.32.02.01.8-1.8-1.8-1.7
Parametrial fat weight10.019.532.74.3-3.35.0-2.72.62.62.6-2.75.35.35.6-5.7-5.6-5.5
Pavlov. Cond. lever latency2.43.04.72.0-2.21.8-2.02.02.02.0-2.11.61.61.2-1.0-0.9-0.9
Pavlov. Cond. magazine entry latency3.64.67.8-2.42.7-2.12.7-2.7-2.7-2.72.8-1.8-1.8-1.20.90.70.8
Pavlov. Cond. change in total contacts2.42.63.2-1.81.7-1.81.5-1.5-1.5-1.51.6-1.8-1.8-1.61.51.41.4
Pavlov. Cond. index score2.53.15.6-2.02.3-1.72.3-2.3-2.3-2.32.4-1.4-1.4-0.90.60.40.5
Pavlov. Cond. latency score2.83.56.4-2.12.5-1.72.4-2.5-2.5-2.52.5-1.4-1.4-0.80.50.30.4
Pavlov. Cond. lever contacts1.72.13.5-1.61.9-1.41.7-1.7-1.7-1.71.9-1.3-1.3-0.80.70.60.6
Pavlov. Cond. magazine entry number1.92.43.71.8-1.91.6-1.81.81.81.8-1.91.41.41.0-0.9-0.8-0.8
Pavlov. Cond. intertrial magazine entries3.13.85.42.2-2.32.1-2.32.32.32.3-2.31.81.81.5-1.2-1.0-1.1
Pavlov. Cond. lever-magazine prob. diff.2.42.95.1-1.92.2-1.62.1-2.2-2.2-2.22.3-1.4-1.4-0.90.70.50.6
Pavlov. Cond. response bias2.32.84.6-1.92.1-1.72.0-2.0-2.0-2.02.2-1.5-1.5-1.00.80.70.7
Pavlov. Cond. lever latency1.52.04.01.3-0.81.6-0.60.70.70.7-0.51.71.71.9-2.0-2.0-1.9
Pavlov. Cond. magazine entry latency0.91.11.5-1.20.8-1.20.8-0.9-0.9-0.90.7-1.2-1.2-1.21.11.01.1
Pavlov. Cond. change in total contacts0.71.01.5-1.00.8-1.20.7-0.7-0.7-0.70.6-1.2-1.2-1.21.21.21.2
Pavlov. Cond. index score0.91.22.8-0.80.3-1.10.1-0.2-0.2-0.20.0-1.3-1.3-1.61.61.71.6
Pavlov. Cond. latency score1.01.33.4-0.80.2-1.20.0-0.1-0.1-0.1-0.1-1.3-1.3-1.71.81.81.8
Pavlov. Cond. lever contacts0.50.61.4-0.70.3-0.90.2-0.2-0.2-0.20.1-0.9-0.9-1.11.21.21.2
Pavlov. Cond. magazine entry number0.60.71.30.8-0.51.0-0.40.50.50.5-0.41.01.01.1-1.1-1.1-1.1
Pavlov. Cond. intertrial magazine entries0.81.11.71.0-0.81.2-0.70.60.60.6-0.61.31.31.3-1.3-1.3-1.3
Pavlov. Cond. lever-magazine prob. diff.0.91.22.9-0.90.3-1.20.2-0.3-0.3-0.30.1-1.3-1.3-1.61.71.71.6
Pavlov. Cond. response bias0.81.01.9-1.00.6-1.20.5-0.5-0.5-0.50.4-1.2-1.2-1.41.41.41.3
Time in closed arm before self-admin0.80.92.3-1.01.1-0.61.3-1.5-1.5-1.51.2-0.2-0.30.1-0.5-0.6-0.4
Time in closed arm after self-admin0.00.00.1-0.30.2-0.2-0.0-0.3-0.3-0.30.2-0.2-0.3-0.10.10.00.1
Time in open arm before self-admin0.91.02.8-0.50.3-0.9-0.10.20.20.20.1-1.2-1.2-1.31.61.71.6
Time in open arm after self-admin0.90.92.01.0-1.20.6-1.31.41.41.4-1.30.40.5-0.10.30.50.3
Bone: periosteal estimation1.43.04.92.0-2.11.7-2.22.22.22.2-2.21.41.41.1-0.6-0.5-0.7
Bone: periosteal perimeter0.91.52.61.4-1.51.2-1.61.61.61.6-1.61.01.00.8-0.4-0.3-0.5
Bone: post-yield work0.40.51.50.5-0.20.7-0.0-0.0-0.0-0.0-0.10.90.91.0-1.2-1.2-1.1
Progressive ratio test 1 active lever presses1.41.52.01.3-1.11.4-1.01.01.01.0-0.91.41.31.4-1.3-1.3-1.4
Progressive ratio test 1 breakpoint1.92.03.21.4-1.11.7-0.91.01.01.0-0.91.61.51.8-1.7-1.7-1.8
Progressive ratio test 1 inactive lever presses1.51.72.71.4-1.61.4-1.61.41.41.4-1.61.41.30.8-0.7-0.6-0.6
Progressive ratio test 2 active lever presses0.90.91.31.0-1.11.1-0.80.80.80.8-1.01.11.11.0-1.0-0.9-0.9
Progressive ratio test 2 breakpoint0.50.50.80.7-0.80.9-0.60.60.60.6-0.80.90.90.7-0.8-0.7-0.7
Progressive ratio test 2 inactive lever presses2.32.63.81.8-1.91.8-1.81.71.71.7-1.91.71.71.3-1.2-1.1-1.1
Incentive Sensitization - Responses0.10.10.30.3-0.50.4-0.20.20.20.2-0.50.50.50.3-0.5-0.4-0.4
Incentive Sensitization - Breakpoint0.10.10.20.3-0.50.4-0.20.20.20.2-0.50.50.50.3-0.4-0.4-0.4
Sum of active levers in priming session hrs 5-60.80.81.8-0.20.80.20.9-0.8-0.8-0.81.00.40.51.0-1.2-1.3-1.2
Progressive ratio0.70.81.71.0-0.90.9-1.11.31.31.3-0.90.60.60.6-0.2-0.2-0.4
Food seeking constrained by brief footshock0.10.10.3-0.30.4-0.40.4-0.0-0.0-0.00.4-0.5-0.5-0.40.50.50.4
Seeking ratio, punishment vs. effort1.11.32.1-1.31.3-1.21.4-1.4-1.4-1.41.2-1.0-1.0-1.00.70.60.8
Retroperitoneal fat weight0.20.61.30.9-1.10.7-1.11.01.01.0-1.10.60.60.3-0.1-0.1-0.2
Reaction time number correct0.10.10.3-0.0-0.10.10.3-0.4-0.4-0.4-0.00.50.50.2-0.6-0.5-0.4
Reaction time mean minus median0.50.61.3-0.60.5-0.90.3-0.1-0.1-0.10.4-1.1-1.1-1.01.11.21.1
Reaction time mean minus median AUC0.10.10.3-0.20.2-0.40.10.20.20.20.1-0.5-0.5-0.40.50.50.5
Reaction time num false alarms1.11.52.2-1.21.2-1.40.9-0.9-0.9-0.91.1-1.5-1.5-1.41.41.31.3
Reaction time num false alarms AUC0.91.21.8-1.10.9-1.20.7-0.7-0.7-0.70.8-1.3-1.3-1.31.31.31.3
Reaction time trials correct on left0.10.10.3-0.0-0.10.10.3-0.4-0.4-0.4-0.00.50.50.2-0.6-0.5-0.4
Reaction time trials on left0.10.10.3-0.0-0.10.10.3-0.3-0.3-0.3-0.10.50.50.2-0.5-0.5-0.4
Reaction time mean0.20.30.5-0.40.4-0.60.3-0.1-0.1-0.10.3-0.7-0.7-0.60.70.70.7
Reaction time mean AUC0.40.61.2-0.60.5-0.80.3-0.1-0.1-0.10.3-1.0-1.0-1.01.11.11.1
Median of all reaction times0.10.10.2-0.20.1-0.30.10.10.10.10.1-0.4-0.4-0.30.50.40.4
Reaction time omissions0.40.50.80.8-0.80.7-0.80.90.90.9-0.80.60.60.6-0.4-0.4-0.4
Reaction time false alarm rate0.71.01.7-0.90.9-1.10.5-0.5-0.5-0.50.8-1.3-1.3-1.21.31.21.2
Reaction time premature initiation rate1.62.23.7-1.81.7-1.51.9-1.9-1.9-1.91.7-1.1-1.2-0.90.50.40.6
Reaction time premature initiations1.31.83.6-1.61.5-1.31.9-1.9-1.9-1.91.6-0.8-0.8-0.70.20.10.3
Std. dev. reaction times1.01.52.3-1.21.0-1.40.8-0.6-0.6-0.60.8-1.5-1.5-1.51.51.51.5
Reaction time trials completed0.10.10.3-0.0-0.10.10.3-0.3-0.3-0.3-0.10.50.50.2-0.5-0.5-0.4
Reaction time trials AUC0.10.10.2-0.1-0.10.10.3-0.3-0.3-0.30.00.40.40.2-0.5-0.5-0.3
Run reversals in cocaine runway, females0.10.10.2-0.30.1-0.40.1-0.3-0.3-0.30.0-0.3-0.3-0.50.40.50.5
Run reversals in cocaine runway, males2.01.93.41.6-1.81.3-1.81.81.81.8-1.81.01.00.5-0.3-0.1-0.2
Latency to leave start box in cocaine runway0.10.10.4-0.30.6-0.30.3-0.2-0.2-0.20.6-0.4-0.4-0.00.20.10.1
Latency to leave start box in cocaine runway, F0.20.20.9-0.40.9-0.20.6-0.4-0.4-0.41.0-0.3-0.30.3-0.1-0.3-0.3
Latency to leave start box in cocaine runway, M0.20.20.30.5-0.50.5-0.50.50.50.5-0.50.50.50.4-0.4-0.4-0.3
Std. dev. time between licks in bursts0.50.60.90.7-0.60.9-0.50.40.40.4-0.51.01.00.9-1.0-0.9-0.9
Total sessions with >9 infusions2.83.14.12.0-1.82.0-2.01.71.71.7-1.71.91.81.7-1.5-1.4-1.5
Short access day 1 total inactive lever presses0.20.20.50.4-0.50.7-0.70.30.30.3-0.50.40.30.3-0.3-0.3-0.4
Short access day 10 total inactive lever presses0.10.20.3-0.50.3-0.40.5-0.6-0.6-0.60.3-0.2-0.3-0.40.20.20.3
Short access day 1 total infusions3.73.98.12.3-2.42.1-2.82.42.42.4-2.51.61.51.2-0.7-0.5-0.7
Short access day 10 total infusions1.71.92.71.6-1.71.6-1.41.31.31.3-1.61.51.41.3-1.2-1.1-1.1
Short access total infusions4.45.07.72.6-2.72.4-2.82.52.52.5-2.72.12.01.7-1.3-1.2-1.3
Short access day 1 locomotion1.21.32.81.3-1.41.0-1.71.61.61.6-1.50.80.70.4-0.1-0.0-0.1
Short access day 10 total locomotion0.80.92.41.0-1.51.0-1.40.90.90.9-1.50.90.90.2-0.3-0.2-0.1
Short access total locomotion0.90.92.11.0-1.41.0-1.41.01.01.0-1.40.90.80.3-0.3-0.1-0.2
One hour access (0.3 mA shock)1.72.02.61.6-1.61.5-1.51.41.41.4-1.51.41.51.2-1.2-1.0-1.0
Compulsive drug intake1.51.53.3-1.41.4-1.01.4-1.8-1.8-1.81.4-0.9-0.8-0.70.20.20.3
One hour access (shock baseline)2.83.24.42.0-2.11.8-2.02.12.12.1-2.01.81.81.4-1.2-1.1-1.1
Social response proportion2.22.45.4-1.41.7-0.82.1-2.3-2.3-2.32.0-0.2-0.10.3-1.0-1.1-0.8
Social responses1.62.04.71.2-0.71.4-0.40.40.40.4-0.51.61.82.0-2.2-2.1-2.0
Social time1.01.33.40.8-0.41.1-0.00.00.00.0-0.11.41.41.6-1.8-1.9-1.7
Soleus weight2.05.814.31.8-0.92.5-0.40.30.30.3-0.43.03.03.4-3.7-3.8-3.6
Bone: stiffness1.72.65.11.5-1.01.8-0.70.70.70.7-0.72.02.02.2-2.3-2.2-2.2
Tibialis anterior weight3.311.417.13.4-2.73.9-2.32.32.32.3-2.24.14.04.1-4.1-4.1-4.0
Time to tail flick, vehicle, before self-admin0.50.51.2-0.20.50.20.8-0.7-0.7-0.70.70.30.20.8-0.9-1.1-1.0
Time to tail flick, vehicle, after self-admin0.10.10.20.4-0.40.4-0.40.40.40.4-0.30.40.40.3-0.3-0.2-0.2
Time to tail flick, test, before self-admin4.14.06.4-2.42.3-2.12.4-2.5-2.5-2.52.3-1.7-1.6-1.41.00.91.0
Time to tail flick, test, after self-admin0.90.91.7-1.11.3-1.01.2-1.1-1.1-1.11.3-0.8-0.9-0.60.50.40.4
Delta time to tail flick, vehicle, before/after SA0.90.92.10.9-1.20.5-1.51.41.41.4-1.30.40.5-0.10.30.50.5
Delta time to tail flick, test, before/after SA1.71.62.91.5-1.41.3-1.51.71.71.7-1.41.00.90.8-0.5-0.4-0.6
Tibia length0.71.84.1-1.31.8-0.82.0-1.9-1.9-1.92.0-0.5-0.50.0-0.3-0.5-0.4
Ambulatory time before self-admin0.30.30.70.4-0.50.2-0.70.80.80.8-0.6-0.2-0.2-0.20.50.60.4
Ambulatory time after self-admin3.03.34.52.0-1.82.1-1.71.61.61.6-1.72.12.01.9-1.7-1.7-1.7
Bone: tissue strength0.20.20.30.3-0.50.1-0.50.50.50.5-0.6-0.1-0.1-0.20.40.40.3
Total heroin consumption1.21.42.9-0.41.00.31.2-1.2-1.2-1.21.20.60.61.3-1.6-1.7-1.7
Bone: trabecular number0.40.61.1-0.50.9-0.11.1-1.0-1.0-1.01.00.10.10.5-0.7-0.8-0.7
Bone: trabecular spacing0.20.30.70.5-0.70.2-0.80.80.80.8-0.80.10.1-0.20.40.40.4
Bone: trabecular thickness0.10.10.40.2-0.10.40.1-0.0-0.0-0.0-0.00.50.50.5-0.6-0.6-0.6
Bone: trabecular tissue density1.52.24.5-1.31.0-1.60.6-0.6-0.6-0.60.7-1.9-1.9-1.92.12.11.9
Water consumed over 24 hours3.94.76.8-2.52.6-2.32.6-2.6-2.6-2.62.5-2.0-2.0-1.51.21.01.1
Number of responses in last shaping day0.60.72.00.8-0.90.5-1.41.11.11.1-1.00.30.3-0.30.40.60.5