Ago3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Ago3 0.11 0.06 6.5e-04 -0 0.02 0.01 -0 9.5e-01 1.8e-03 2.2e-02 5.8e-01
2 Adipose alternative TSS XM_008764024.3 0.05 0.03 6.2e-03 0.01 -0 0 -0 1.4e-02 4.6e-01 1.3e-01 4.4e-01
3 Liver alternative polyA NM_001271193.1 0.12 0.06 1.4e-04 0.03 0.04 0.05 0.03 1.5e-04 1.6e-05 6.3e-06 3.8e-04
4 Liver alternative TSS NM_001271193.1 0.14 0.07 2.0e-04 0.02 0.03 0.02 0.02 2.7e-03 1.0e-04 1.2e-03 1.7e-03
5 Liver alternative polyA XM_039110019.1 0.1 0.06 3.2e-04 0.03 0.04 0.04 0.03 1.8e-04 5.7e-05 8.1e-05 7.3e-04
6 Liver alternative TSS XM_008764024.3 0.12 0.07 3.6e-04 0.02 0.04 0.02 0.02 2.7e-03 3.8e-05 1.3e-03 1.7e-03
7 Liver intron excision ratio chr5_138686272_138690252 0.04 0.03 6.8e-04 0.02 0 0 0.01 1.1e-03 2.2e-01 1.1e-01 3.1e-02
8 Liver isoform ratio XM_039110019.1 0.12 0.06 4.1e-07 0.06 0.07 0.07 0.06 1.3e-07 6.3e-08 5.2e-08 4.8e-07
9 OFC mRNA stability Ago3 0.3 0.14 2.0e-03 0.01 0.11 0.05 0.06 1.5e-01 1.3e-03 2.1e-02 1.9e-02
10 Liver gene expression Ago3 0.24 0.11 3.1e-07 0.02 0.06 0.06 0.04 2.0e-03 6.9e-07 3.2e-07 1.8e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density1.32.24.7-1.4-1.50.91.4-1.9-1.5-1.30.7-1.3-2.2
Area under the delay curve0.30.31.50.30.5-0.90.20.90.00.1-1.2-0.1-0.1
BMI with tail0.92.87.5-2.6-2.01.10.1-2.5-0.5-0.02.7-0.9-1.3
BMI without tail0.61.23.4-1.80.4-1.7-0.2-0.60.11.71.50.00.1
Body weight0.41.73.6-1.9-0.31.01.8-1.4-1.7-0.90.3-1.0-1.4
Weight adjusted by age1.21.32.50.1-1.6-1.1-0.90.61.11.21.5-1.5-1.1
Bone surface1.22.04.2-2.0-1.00.61.6-1.3-1.5-0.80.5-1.6-2.0
Bone volume1.62.85.2-2.0-1.00.72.1-2.1-2.3-1.40.4-1.0-2.3
Breakpoint value in progressive ratio session0.50.51.9-0.2-1.40.4-0.3-0.90.1-0.41.3-0.5-0.3
Number of licking bursts0.50.61.00.4-0.31.00.8-1.0-0.8-0.80.9-0.3-0.9
Context. condit. distance diff. score0.60.82.7-0.5-0.6-0.8-1.60.21.40.80.20.50.9
Locomotion velocity, session 10.20.31.00.91.00.10.40.2-0.20.30.00.3-0.6
Locomotion distance, session 10.10.10.5-0.70.30.50.3-0.2-0.3-0.2-0.30.10.0
Locomotion velocity, session 20.50.64.42.10.5-0.20.10.5-0.0-0.1-0.20.1-0.7
Locomotion distance, session 20.10.10.2-0.30.10.40.10.00.00.00.4-0.5-0.3
Locomotion velocity, session 30.91.13.0-0.90.0-0.6-1.70.51.71.60.50.10.7
Locomotion distance, session 30.30.31.1-1.0-0.80.4-0.7-0.50.50.10.6-0.00.2
Stereotopy head waving bouts, day 30.20.30.6-0.70.6-0.4-0.40.80.60.8-0.4-0.10.3
Stereotopy head waving duration, day 31.51.73.6-0.21.6-1.8-0.91.91.21.9-1.10.30.8
Locomotion velocity, session 71.01.13.1-0.30.5-1.6-1.21.11.31.80.2-0.10.5
Locomotion distance, session 70.20.20.60.2-0.3-0.30.2-0.8-0.5-0.30.50.60.0
Stereotopy head waving bouts, day 70.30.31.20.40.10.40.50.3-0.10.60.4-1.0-1.1
Stereotopy head waving duration, day 70.20.31.00.2-0.50.10.20.0-0.00.50.6-1.0-1.0
Locomotion velocity, session 80.40.51.6-0.0-1.10.4-0.5-0.40.5-0.11.3-0.8-0.8
Locomotion distance, session 80.81.22.9-1.2-0.9-0.5-1.70.31.71.31.3-0.60.3
Degree of sensitization distance0.60.62.71.60.5-0.60.90.2-0.9-0.3-0.40.1-0.7
Degree of sensitization stereotypy0.20.20.6-0.0-0.30.80.5-0.2-0.3-0.00.3-0.7-0.8
Conditioned locomotion2.73.18.41.8-1.62.90.2-2.4-1.1-2.6-0.31.80.4
Cocaine response after cond. corrected0.40.41.7-0.4-1.30.7-0.2-0.60.1-0.40.9-0.6-0.2
Cocaine response after cond. not corrected0.30.31.0-1.0-0.80.00.1-0.7-0.2-0.30.6-0.4-0.3
Cocaine response before conditioning0.50.62.7-1.01.1-1.60.30.2-0.30.4-0.80.4-0.1
Saline control response0.10.10.4-0.40.00.50.2-0.1-0.2-0.0-0.0-0.4-0.6
Bone: connectivity density1.11.73.7-1.3-1.51.10.9-1.5-1.0-1.00.9-1.3-1.9
Bone: cortical apparent density0.30.41.70.0-0.5-0.7-0.8-0.50.50.61.30.30.2
Bone: cortical area0.30.52.0-1.00.40.30.30.80.20.70.0-1.4-0.6
Bone: cortical porosity0.80.94.42.1-0.20.90.8-0.0-0.7-1.5-0.80.3-0.3
Bone: cortical porosity0.60.74.22.1-0.10.30.70.2-0.6-1.0-0.70.0-0.5
Bone: cortical thickness0.61.02.1-1.5-1.31.0-1.1-0.51.00.51.1-0.9-0.1
Bone: cortical thickness0.50.61.9-1.40.2-0.4-1.10.11.00.6-0.00.41.2
Bone: cortical tissue density0.30.51.60.0-0.5-0.8-0.9-0.50.60.71.30.40.3
Condit. Reinf. active minus inactive responses0.40.52.7-1.6-0.2-0.80.2-0.5-0.5-0.4-0.70.1-0.2
Condit. Reinf. active-inactive response ratio0.30.31.5-1.20.1-0.70.1-0.6-0.5-0.1-0.60.60.4
Condit. Reinf. active responses0.30.42.3-1.5-0.4-0.5-0.2-0.20.0-0.5-1.0-0.1-0.1
Condit. Reinf. inactive responses0.20.20.6-0.5-0.5-0.0-0.70.30.6-0.6-0.8-0.00.1
Incentive salience index mean1.01.28.9-3.0-0.2-0.40.6-0.6-0.7-0.7-1.0-0.4-0.4
Condit. Reinf. lever presses0.91.29.2-3.00.2-0.30.50.0-0.5-0.5-1.4-0.6-0.2
Condit. Reinf. active minus inactive responses0.10.10.4-0.00.6-0.60.20.5-0.10.1-0.40.1-0.0
Condit. Reinf. active-inactive response ratio0.30.30.90.40.4-0.21.0-0.1-0.9-0.6-0.5-0.0-0.8
Condit. Reinf. active responses0.40.52.1-0.90.6-1.5-0.40.80.60.90.2-0.10.4
Condit. Reinf. inactive responses1.92.37.6-2.80.1-1.7-1.80.61.71.50.40.21.8
Condit. Reinf. lever presses0.70.92.4-0.50.1-0.01.1-1.5-1.5-1.2-0.21.1-0.3
Condit. Reinf. lever reinforcers received0.60.83.4-1.40.8-1.8-0.40.70.51.0-0.10.20.6
Conditioned reinforcement - actives1.71.73.80.80.52.01.9-1.0-1.9-1.7-0.40.3-0.9
Conditioned reinforcement - inactives0.91.02.21.10.21.01.4-0.9-1.5-1.10.80.6-0.5
Conditioned locomotion0.40.51.50.00.2-1.0-0.60.60.81.20.9-0.40.2
Patch foraging indifference point 0 sec1.01.65.80.41.80.21.60.2-1.5-1.1-2.40.9-0.1
Patch foraging indifference point AUC2.73.27.41.2-0.32.02.2-2.2-2.6-2.7-0.50.9-1.2
Delay disc. indifference point, 0s delay0.30.31.6-0.1-0.10.10.60.4-0.5-0.7-1.3-0.7-0.4
Delay disc. indifference point, 16s delay0.90.93.70.70.9-1.9-0.11.60.51.1-0.6-0.40.0
Delay disc. indifference point, 2s delay0.70.82.2-0.40.4-1.5-1.11.21.10.6-1.0-0.10.7
Delay disc. indifference point, 24s delay1.81.74.52.02.1-0.81.11.3-0.90.1-1.71.30.1
Delay disc. indifference point, 4s delay1.61.74.9-1.7-0.8-0.9-2.20.92.10.9-0.3-0.51.2
Delay disc. indifference point, 8s delay0.10.10.9-0.10.20.00.20.2-0.1-0.1-1.0-0.1-0.4
Indifference point function ln k2.63.69.2-2.40.8-3.0-1.71.72.02.90.5-0.51.2
Indifference point function log k2.63.69.2-2.40.8-3.0-1.71.72.02.90.5-0.51.2
Patch foraging total patch changes 0 sec1.01.65.70.22.1-0.21.60.3-1.4-0.9-2.41.00.1
Patch foraging total patch changes 12 sec3.24.113.03.62.10.32.30.2-2.3-1.8-2.71.7-0.0
Patch foraging total patch changes 18 sec3.64.613.0-0.20.12.82.4-2.8-2.9-3.6-1.01.3-0.7
Patch foraging total patch changes 24 sec2.12.56.5-0.50.81.42.0-1.5-2.2-2.5-1.71.30.2
Patch foraging total patch changes 6 sec1.11.64.2-0.1-0.52.11.4-1.4-1.6-2.0-0.4-0.0-1.1
Patch foraging time to switch 0 sec0.10.20.60.2-0.60.2-0.20.10.30.20.7-0.7-0.3
Patch foraging water rate 0 sec0.30.41.6-0.21.3-1.00.30.9-0.00.7-0.40.20.4
Patch foraging water rate 12 sec0.60.93.4-0.41.9-1.00.31.30.11.4-0.50.10.3
Patch foraging water rate 18 sec0.50.73.9-0.20.9-2.0-0.10.50.21.30.40.30.4
Patch foraging water rate 24 sec0.50.71.80.61.3-0.8-0.40.60.30.6-0.51.31.3
Patch foraging water rate 6 sec1.42.15.90.31.9-2.4-0.71.81.02.0-0.50.81.3
Seeking ratio, delayed vs. immediate footshock0.40.51.90.60.80.5-0.1-0.1-0.1-0.7-1.11.40.6
Distance traveled before self-admin1.31.43.40.5-0.1-1.2-0.91.51.31.80.5-1.4-1.4
Distance traveled after self-admin0.60.71.30.7-0.4-1.1-1.01.01.11.20.7-0.3-0.2
Extensor digitorum longus weight1.66.219.6-3.1-2.72.31.6-4.4-2.4-2.31.7-0.3-1.6
Bone: elastic displacement1.01.14.50.3-2.1-0.1-1.5-0.41.20.21.4-0.6-0.0
Bone: elastic work0.50.63.1-0.4-1.80.3-0.2-1.4-0.3-0.70.5-0.2-0.4
Bone: endosteal estimation1.12.57.10.32.7-1.52.21.8-1.40.5-1.8-0.7-1.1
Bone: endosteal perimeter0.61.23.10.21.5-0.41.81.2-1.00.3-0.7-1.2-1.3
Epididymis fat weight0.30.61.8-0.21.20.1-0.71.31.01.0-0.3-0.10.4
Delta time in closed arm before/after self-admin1.31.23.91.60.40.62.0-0.6-1.8-1.1-0.3-0.2-0.8
Delta time in open arm before/after self-admin4.03.89.3-1.61.7-2.5-1.82.02.02.2-0.51.03.0
Diff in mean of infusions in LGA sessions0.50.61.3-0.3-0.1-1.1-1.00.81.11.10.3-0.00.7
Delay discount exponential model param0.40.41.2-0.2-0.51.00.2-1.0-0.3-0.31.10.0-0.1
Extinction: sum of active levers before priming0.60.62.0-0.3-1.40.7-0.2-1.2-0.3-1.3-0.5-0.00.4
Active lever presses in extinction session 61.21.23.4-0.0-1.61.90.1-1.4-0.4-1.30.7-0.4-1.1
Bone: final force0.50.82.7-0.30.6-0.90.61.30.01.0-0.2-1.6-0.7
Bone: final moment0.61.03.1-0.20.8-1.10.61.60.11.1-0.3-1.7-0.8
Food consumed during 24 hour testing period1.01.23.71.11.5-0.60.5-0.2-0.8-0.3-1.11.91.4
Glucose1.72.59.03.00.6-0.2-1.82.32.11.2-0.40.21.1
Heart weight0.60.93.40.5-0.21.80.6-0.8-0.7-1.4-0.4-0.4-1.3
Delay discount hyperbolic model param0.40.51.2-0.0-0.41.10.5-1.1-0.6-0.41.10.0-0.3
Intermittent access intake day 1-15 change3.83.89.81.02.8-0.51.30.6-1.3-0.6-3.13.02.3
Intermittent access intake escalation3.63.610.21.22.7-0.51.40.6-1.4-0.5-3.22.81.9
Intermittent access intake escalation 23.03.09.41.51.9-1.30.30.4-0.6-0.1-2.43.12.5
Intermitt. access day 1 inactive lever presses0.70.72.0-0.71.2-0.6-0.60.70.60.6-0.51.01.4
Intermitt. access day 15 inactive lever presses0.70.72.41.30.50.20.6-0.6-0.9-0.7-0.41.50.9
Intermitt. access escalation Index1.41.22.9-1.1-1.01.70.7-1.4-0.9-1.50.3-0.5-1.0
Intermittent access day 1 total infusions0.20.21.0-0.50.60.3-0.30.00.40.31.00.20.5
Intermittent access day 15 total infusions1.51.75.40.62.3-0.00.70.3-0.7-0.2-1.62.21.7
Intermittent access terminal intake (last 3 days)1.01.13.40.91.5-0.00.8-0.3-1.0-0.5-0.81.81.2
Intermittent access total infusions0.80.84.50.02.1-0.30.30.6-0.20.3-0.61.21.2
Intermittent access day 1 locomotion0.30.31.1-0.51.1-0.1-0.30.70.50.40.2-0.20.5
Intermittent access day 15 total locomotion0.60.61.61.31.0-0.00.9-0.2-0.9-0.5-0.11.10.6
Intermittent access total locomotion0.40.51.90.81.4-0.60.20.60.00.50.00.60.8
Intermittent access standard deviation1.01.03.2-0.90.4-1.0-1.20.41.11.00.41.01.8
Left kidney weight0.10.30.7-0.60.3-0.60.8-0.3-0.8-0.3-0.3-0.4-0.4
Right kidney weight0.20.72.40.70.0-0.11.0-0.1-0.8-0.00.5-1.4-1.6
Cocaine induced anxiety1.21.47.8-2.80.5-0.6-0.41.40.80.3-0.3-1.41.0
Post-drug Anxiety0.80.94.8-2.2-1.21.1-0.2-0.40.2-0.70.5-1.00.1
Baseline Anxiety2.83.06.91.0-2.22.50.7-2.6-1.3-1.61.50.1-1.9
Tail length0.41.12.8-0.51.3-1.71.60.7-1.10.4-0.6-0.9-0.8
Length with tail0.62.37.10.51.20.72.70.4-2.1-1.6-2.1-0.8-1.1
Length without tail1.22.78.41.0-0.82.91.9-0.4-1.5-2.4-0.7-1.4-1.7
Times rat made contact with spout0.20.20.60.40.20.6-0.2-0.50.10.30.80.5-0.0
Lifetime Intake0.70.83.40.61.90.20.90.0-0.8-0.3-0.41.40.8
Liver weight, left0.20.41.10.11.0-0.51.00.4-0.7-0.2-0.7-0.4-0.5
Liver weight, right0.20.41.20.70.80.40.70.5-0.5-0.4-1.10.10.1
Locomotor activity1.52.45.8-0.90.0-1.8-1.51.72.02.41.7-1.70.1
Locomotor testing distance1.22.15.41.11.0-2.2-1.12.01.52.30.6-0.60.2
Locomotor testing rearing1.11.74.82.20.7-1.3-1.31.41.41.50.30.51.2
Locomotion in novel chamber0.91.14.0-0.0-0.1-0.8-2.00.61.71.10.40.91.2
Locomotion in novel chamber post-restriction0.20.30.9-0.70.2-0.60.11.00.30.3-0.0-0.9-0.4
Fecal boli incidents, locomotor time 10.00.00.30.1-0.5-0.0-0.0-0.0-0.0-0.20.30.00.1
Change in fecal boli incidents, locomotor task0.30.30.80.70.9-0.10.80.1-0.7-0.1-0.50.40.4
Time >=10cm from walls, locomotor time 11.31.33.90.80.9-0.52.00.9-1.30.0-1.0-1.2-1.4
Bouts of movement, locomotor time 11.11.23.3-0.10.5-1.0-1.81.01.71.40.40.70.9
Total resting periods, locomotor time 11.21.44.2-0.50.5-0.8-2.00.91.91.40.40.81.1
Rest time, locomotor task time 13.13.47.2-0.71.5-1.5-2.51.72.31.7-1.11.72.7
Distance moved, locomotor task time 10.60.72.11.40.4-0.01.3-0.1-1.1-0.4-0.3-0.3-1.2
Vertical activity count, locomotor time 10.50.51.7-0.70.10.21.30.2-0.9-0.8-0.4-1.1-0.3
Time >=10cm from walls, locomotor time 21.01.13.0-0.4-0.30.61.7-0.3-1.3-0.70.0-1.5-1.5
Bouts of movement, locomotor time 20.80.82.40.4-0.1-1.5-1.00.41.01.41.0-0.40.5
Total resting periods, locomotor time 20.70.71.6-0.1-0.2-1.3-1.10.31.11.21.1-0.30.6
Rest time, locomotor task time 22.22.66.5-0.9-0.1-2.0-2.50.62.21.6-0.11.02.5
Distance moved, locomotor task time 20.20.30.7-0.10.10.80.60.1-0.6-0.8-0.8-0.0-0.3
Vertical activity count, locomotor time 20.70.71.6-0.90.20.91.30.6-0.9-0.9-1.2-0.7-0.7
Light reinforcement 11.11.95.61.91.8-0.61.3-0.6-1.5-0.5-1.42.40.1
Light reinforcement 20.81.03.60.51.9-1.10.6-0.0-0.70.6-0.91.7-0.0
Bone: marrow area1.12.46.60.32.6-1.52.21.9-1.30.5-1.7-0.8-1.1
Bone: maximum diameter0.61.24.5-0.60.80.31.20.9-0.50.90.4-2.1-1.6
Bone: maximum force0.40.72.2-0.70.6-1.00.41.30.21.0-0.3-1.5-0.6
Bone: maximum moment0.50.92.4-0.60.8-1.10.51.60.21.1-0.4-1.6-0.6
Mean time between licks in bursts1.21.73.7-0.80.3-1.9-1.80.71.61.2-0.31.11.9
Mean num. licks in bursts0.60.71.6-0.10.6-0.6-1.00.60.91.0-0.61.01.3
Cd content in liver0.70.83.7-1.60.8-1.9-0.20.20.10.8-0.50.50.4
Co content in liver0.70.84.12.00.3-0.90.60.8-0.20.40.4-0.9-0.7
Cu content in liver3.34.06.81.2-1.72.62.3-1.8-2.3-2.60.4-1.4-2.4
Fe content in liver0.50.51.81.31.00.50.61.0-0.2-0.1-0.9-0.4-0.1
K content in liver0.50.51.70.80.1-0.30.90.3-0.60.40.0-0.9-1.3
Mg content in liver1.21.210.73.30.31.00.30.6-0.20.0-0.20.4-0.1
Mn content in liver2.63.07.82.6-1.92.80.7-2.1-1.2-1.71.00.2-1.2
Na content in liver0.91.03.10.01.3-0.80.51.80.10.8-1.4-1.0-0.7
Rb content in liver0.70.92.71.2-0.70.00.40.3-0.00.61.3-1.6-1.5
Se content in liver2.42.915.64.00.12.30.9-0.2-1.0-2.1-1.11.0-0.0
Sr content in liver7.26.639.9-6.3-0.9-1.61.5-3.2-2.10.01.1-0.7-1.9
Zn content in liver0.50.63.21.80.10.80.6-0.1-0.5-0.40.2-0.1-1.0
Bone: minimum diameter0.40.72.20.01.5-0.71.11.0-0.70.3-0.9-0.5-0.7
Time in familiar zone, hab. session 10.40.41.10.2-0.10.20.90.1-0.60.30.5-1.0-1.0
Time in novel zone, hab. session 10.50.51.91.00.8-0.30.2-0.1-0.4-0.6-0.81.40.5
Total zone transitions, hab. session 10.30.51.3-0.8-0.81.1-0.3-0.80.1-0.21.1-0.5-0.2
Total locomotion distance, hab. session 10.30.41.0-1.0-0.50.6-0.8-0.20.70.30.8-0.5-0.0
Locomotion velocity, hab. session 10.50.82.5-1.6-0.90.8-0.9-0.20.90.21.0-0.9-0.1
Time in familiar zone, hab. session 20.80.82.30.70.1-1.5-0.31.00.61.30.9-0.9-0.6
Time in novel zone, hab. session 20.50.51.2-0.40.20.70.2-0.5-0.4-1.0-1.11.10.7
Total zone transitions, hab. session 20.81.12.4-1.3-0.0-0.6-1.50.71.51.60.4-0.31.0
Total locomotion distance, hab. session 20.70.92.2-1.40.1-0.2-1.50.61.51.2-0.1-0.01.1
Locomotion velocity, hab. session 20.60.82.3-1.5-0.10.3-1.30.21.30.90.1-0.11.0
Novel to familiar place preference ratio1.21.23.5-1.4-0.2-0.6-1.90.41.71.00.20.41.4
Novelty place preference1.51.54.5-1.4-0.1-0.6-2.10.21.81.00.20.81.7
Time in novel zone, NPP test1.41.44.3-1.2-0.1-0.8-2.10.31.81.10.20.71.6
Total zone transitions, NPP test0.71.02.8-1.4-0.80.0-0.40.10.60.91.6-1.7-0.6
Total locomotion distance, NPP test0.30.41.9-1.4-0.20.1-0.50.30.60.50.5-0.90.2
Locomotion velocity, NPP test0.30.42.4-1.5-0.30.4-0.20.10.40.20.6-1.00.1
Intraocular pressure0.71.02.8-0.70.30.50.8-1.7-1.3-1.4-0.71.20.2
Delta distance traveled before/after self-admin0.60.61.70.1-0.00.60.8-0.8-1.0-1.3-0.21.00.9
Delta ambulatory time before/after self-admin0.91.02.9-0.3-0.81.40.7-1.3-1.0-1.70.00.70.5
Parametrial fat weight0.20.31.7-0.6-0.1-0.20.4-1.3-0.7-0.10.30.7-0.1
Pavlov. Cond. lever latency0.81.13.21.8-1.3-0.2-0.80.30.90.61.6-1.0-0.4
Pavlov. Cond. magazine entry latency0.40.51.1-1.00.7-0.10.9-0.3-0.9-0.5-1.00.3-0.5
Pavlov. Cond. change in total contacts2.02.18.1-1.02.3-1.20.50.8-0.50.0-2.91.71.1
Pavlov. Cond. index score0.60.82.3-1.41.30.10.8-0.1-0.9-0.4-1.50.70.1
Pavlov. Cond. latency score0.70.92.7-1.51.50.00.60.2-0.6-0.3-1.60.80.4
Pavlov. Cond. lever contacts1.01.23.9-1.51.30.10.7-0.1-0.8-0.8-2.01.20.7
Pavlov. Cond. magazine entry number0.40.51.50.6-1.20.3-0.3-0.20.3-0.21.2-0.9-0.4
Pavlov. Cond. intertrial magazine entries1.31.53.71.4-0.1-1.0-1.91.51.90.9-0.30.51.3
Pavlov. Cond. lever-magazine prob. diff.0.70.82.3-1.50.90.31.0-0.5-1.1-0.6-1.30.5-0.1
Pavlov. Cond. response bias0.60.72.1-1.01.2-0.30.8-0.1-0.8-0.3-1.50.80.2
Pavlov. Cond. lever latency0.50.72.80.2-0.80.5-0.40.60.70.60.8-1.7-0.8
Pavlov. Cond. magazine entry latency0.20.20.7-0.0-0.80.10.3-0.7-0.5-0.90.3-0.1-0.4
Pavlov. Cond. change in total contacts1.92.65.70.12.4-1.7-0.61.50.60.5-2.32.12.1
Pavlov. Cond. index score0.30.41.4-0.10.6-0.70.3-0.2-0.5-0.6-1.01.20.6
Pavlov. Cond. latency score0.60.71.90.40.5-0.20.8-0.7-1.1-1.1-1.01.40.3
Pavlov. Cond. lever contacts0.50.72.0-0.61.0-1.00.5-0.3-0.7-0.3-1.01.40.7
Pavlov. Cond. magazine entry number0.00.00.20.20.10.4-0.00.10.10.40.2-0.2-0.1
Pavlov. Cond. intertrial magazine entries0.50.62.6-0.7-0.90.2-0.6-0.90.30.61.6-0.3-0.5
Pavlov. Cond. lever-magazine prob. diff.0.40.51.6-0.30.7-0.90.1-0.1-0.3-0.5-1.11.30.9
Pavlov. Cond. response bias0.40.51.5-1.20.6-1.2-0.1-0.2-0.1-0.0-0.71.00.8
Time in closed arm before self-admin0.70.83.11.00.10.50.3-0.0-0.10.51.5-0.8-1.8
Time in closed arm after self-admin1.01.02.31.50.61.21.3-0.8-1.3-0.80.20.2-1.2
Time in open arm before self-admin0.40.41.6-1.0-1.30.5-0.5-0.50.3-0.6-0.4-0.20.0
Time in open arm after self-admin2.52.76.0-1.80.6-2.1-1.81.71.91.6-0.80.42.4
Bone: periosteal estimation0.71.53.9-0.12.0-0.71.51.7-0.70.7-1.2-1.2-1.0
Bone: periosteal perimeter0.81.33.4-1.11.1-0.11.40.9-0.60.8-0.0-1.9-1.7
Bone: post-yield work1.72.36.61.82.6-0.50.82.5-0.10.1-2.30.30.5
Progressive ratio test 1 active lever presses1.01.03.20.80.60.71.8-0.9-1.7-0.90.90.3-0.4
Progressive ratio test 1 breakpoint0.70.72.00.60.40.71.4-0.9-1.4-0.80.90.3-0.3
Progressive ratio test 1 inactive lever presses1.01.13.90.51.80.00.7-0.2-0.9-0.1-0.12.01.4
Progressive ratio test 2 active lever presses1.11.22.31.31.30.91.5-0.8-1.5-0.9-0.21.30.4
Progressive ratio test 2 breakpoint0.91.02.20.91.50.51.1-0.5-1.1-0.6-0.31.51.0
Progressive ratio test 2 inactive lever presses0.50.61.80.41.20.60.3-0.2-0.4-0.5-0.31.31.1
Incentive Sensitization - Responses0.80.81.81.11.10.60.9-0.6-1.0-0.7-0.41.30.6
Incentive Sensitization - Breakpoint0.80.82.01.11.20.40.8-0.5-0.9-0.6-0.51.40.8
Sum of active levers in priming session hrs 5-63.13.08.40.7-2.91.80.8-2.6-1.4-2.01.5-0.6-1.6
Progressive ratio1.11.27.02.60.30.01.2-0.7-1.3-0.70.30.9-0.4
Food seeking constrained by brief footshock0.60.72.00.8-0.60.21.4-0.4-1.3-0.80.1-0.5-1.2
Seeking ratio, punishment vs. effort0.70.95.1-2.3-0.70.2-0.50.60.70.2-0.5-1.3-0.4
Retroperitoneal fat weight0.20.62.1-0.30.31.50.6-0.5-0.50.10.9-0.5-1.1
Reaction time number correct1.82.69.41.23.1-1.71.51.7-1.00.7-2.11.00.2
Reaction time mean minus median0.70.92.3-1.5-1.50.3-1.4-0.71.00.00.7-0.10.7
Reaction time mean minus median AUC0.40.61.4-1.2-0.90.4-1.0-0.60.6-0.20.00.41.1
Reaction time num false alarms0.40.52.2-1.3-0.2-0.60.2-1.5-0.7-0.10.50.6-0.1
Reaction time num false alarms AUC0.50.72.3-1.4-0.3-0.90.5-1.5-0.9-0.00.60.1-0.6
Reaction time trials correct on left1.82.69.41.23.1-1.71.51.7-1.00.7-2.11.00.2
Reaction time trials on left1.82.69.11.23.0-1.71.61.6-1.00.6-2.11.10.2
Reaction time mean0.60.83.3-0.3-1.5-0.1-1.0-0.60.90.41.8-0.6-0.1
Reaction time mean AUC0.50.72.6-0.2-1.50.2-0.6-0.90.40.01.6-0.5-0.2
Median of all reaction times0.40.62.80.5-1.1-0.1-0.8-0.30.70.41.7-0.4-0.2
Reaction time omissions0.20.21.0-1.0-0.5-0.3-0.3-0.80.00.20.40.30.4
Reaction time false alarm rate0.91.23.8-1.7-1.50.0-0.5-2.0-0.1-0.11.6-0.2-0.5
Reaction time premature initiation rate0.10.20.7-0.4-0.80.4-0.0-0.10.1-0.30.1-0.8-0.4
Reaction time premature initiations0.20.31.0-0.10.8-0.40.90.4-0.7-0.2-1.0-0.1-0.4
Std. dev. reaction times0.91.33.4-1.8-1.8-0.0-1.2-1.10.90.41.6-0.60.1
Reaction time trials completed1.82.69.11.23.0-1.71.61.6-1.00.6-2.11.10.2
Reaction time trials AUC1.82.69.21.03.0-1.61.71.5-1.20.5-2.31.20.3
Run reversals in cocaine runway, females3.73.68.90.40.9-3.0-2.22.42.42.6-0.10.01.5
Run reversals in cocaine runway, males0.90.92.0-1.3-0.61.1-0.1-1.1-0.3-1.4-1.30.50.4
Latency to leave start box in cocaine runway0.60.61.70.5-0.90.5-0.9-1.20.3-0.11.01.30.4
Latency to leave start box in cocaine runway, F0.70.72.10.2-1.01.4-0.5-1.50.1-0.21.20.6-0.3
Latency to leave start box in cocaine runway, M0.40.41.40.9-0.7-1.2-0.5-0.10.30.20.80.40.3
Std. dev. time between licks in bursts0.10.10.60.3-0.20.1-0.0-0.2-0.0-0.20.7-0.2-0.5
Total sessions with >9 infusions1.21.32.41.20.91.51.4-1.0-1.5-1.30.01.2-0.4
Short access day 1 total inactive lever presses0.30.30.60.40.7-0.8-0.10.30.20.70.80.60.7
Short access day 10 total inactive lever presses4.04.47.8-1.41.1-2.6-2.62.42.82.7-0.20.42.5
Short access day 1 total infusions1.01.12.30.40.61.51.3-1.2-1.5-1.40.40.9-0.2
Short access day 10 total infusions0.50.61.81.21.4-0.50.70.2-0.60.30.11.00.2
Short access total infusions1.01.22.50.90.81.31.5-1.1-1.6-1.20.41.1-0.2
Short access day 1 locomotion0.20.21.1-0.20.51.1-0.1-0.4-0.0-0.20.50.5-0.2
Short access day 10 total locomotion1.11.33.00.21.0-1.2-1.51.31.61.70.20.40.8
Short access total locomotion0.20.20.70.10.90.2-0.50.30.50.50.40.40.2
One hour access (0.3 mA shock)0.91.03.30.31.8-0.80.30.5-0.30.4-1.11.51.5
Compulsive drug intake0.60.61.3-1.00.70.60.7-0.0-0.8-0.9-1.20.61.0
One hour access (shock baseline)0.10.10.4-0.20.6-0.1-0.30.00.20.5-0.20.50.4
Social response proportion0.90.94.2-0.1-2.11.2-1.1-0.70.7-1.10.4-0.4-0.2
Social responses0.20.31.20.4-0.80.2-0.3-0.6-0.1-1.1-0.10.70.5
Social time1.11.45.1-1.0-1.21.30.7-1.8-1.2-2.3-0.10.40.2
Soleus weight0.82.58.3-2.9-0.60.92.0-1.5-1.9-1.1-0.2-1.2-1.6
Bone: stiffness0.40.61.8-0.70.5-0.60.11.10.41.0-0.1-1.3-0.4
Tibialis anterior weight1.03.59.9-2.5-1.73.11.2-2.7-1.6-1.90.5-0.5-1.0
Time to tail flick, vehicle, before self-admin0.60.62.3-0.31.5-0.2-0.41.20.71.1-0.4-0.2-0.3
Time to tail flick, vehicle, after self-admin2.02.27.7-2.80.6-0.7-1.71.32.01.60.1-1.20.8
Time to tail flick, test, before self-admin0.90.83.0-0.3-1.70.8-0.7-1.20.4-0.21.3-0.6-0.7
Time to tail flick, test, after self-admin1.71.85.8-2.4-1.41.1-0.1-0.20.4-0.21.3-2.3-1.2
Delta time to tail flick, vehicle, before/after SA0.40.41.8-1.3-1.0-0.0-0.1-0.30.1-0.20.2-1.00.2
Delta time to tail flick, test, before/after SA0.40.41.6-0.60.4-0.30.70.7-0.20.40.1-1.3-0.6
Tibia length0.71.97.70.60.8-1.7-0.22.81.11.6-0.6-1.7-0.4
Ambulatory time before self-admin1.11.13.00.20.1-1.2-1.01.51.41.70.2-1.1-0.9
Ambulatory time after self-admin0.20.20.40.3-0.4-0.5-0.30.60.50.60.4-0.4-0.4
Bone: tissue strength2.02.04.30.4-0.7-1.9-0.91.81.41.90.9-2.1-0.9
Total heroin consumption0.70.82.80.1-1.60.5-0.1-0.8-0.0-0.01.7-1.0-1.0
Bone: trabecular number1.21.94.7-1.1-1.71.20.9-1.5-1.0-1.11.0-1.5-2.2
Bone: trabecular spacing1.41.85.11.22.3-1.1-0.41.20.40.8-1.42.01.6
Bone: trabecular thickness1.51.84.00.2-0.61.31.7-2.0-1.9-1.60.6-0.0-1.5
Bone: trabecular tissue density0.50.72.71.51.0-0.20.01.60.50.6-0.5-0.50.3
Water consumed over 24 hours0.20.20.8-0.5-0.60.2-0.0-0.40.10.00.9-0.8-0.5
Number of responses in last shaping day1.61.64.50.20.50.92.1-0.1-1.6-0.40.9-1.7-2.0