Hub : Genes

Adss1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	XM_003750237.4	0.04	0.04	1.9e-04	0.04	0.04	0.04	0.04	1.6e-04	2.0e-04	2.2e-04	1.6e-04
2	Brain	alternative TSS	XM_003750237.4	0.05	0.05	3.5e-04	0.04	0.04	0.03	0.04	5.8e-05	1.8e-04	7.9e-04	1.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.0	0.0	0.0	0.1	-0.1
Area under the delay curve	0.0	0.0	0.0	0.1	-0.1
BMI with tail	2.2	7.1	7.2	2.7	-2.6
BMI without tail	0.6	1.3	1.4	1.2	-1.1
Body weight	0.7	2.9	3.2	-1.8	1.6
Weight adjusted by age	0.4	0.5	0.5	-0.6	0.7
Bone surface	0.0	0.1	0.1	0.3	-0.2
Bone volume	0.0	0.0	0.1	0.3	-0.1
Breakpoint value in progressive ratio session	0.5	0.6	0.7	0.7	-0.8
Number of licking bursts	0.0	0.1	0.1	0.3	-0.1
Context. condit. distance diff. score	4.2	5.1	5.1	-2.3	2.2
Locomotion velocity, session 1	0.2	0.2	0.2	-0.5	0.4
Locomotion distance, session 1	0.5	0.6	0.7	0.7	-0.8
Locomotion velocity, session 2	0.0	0.0	0.0	0.0	0.1
Locomotion distance, session 2	0.2	0.3	0.3	0.6	-0.5
Locomotion velocity, session 3	0.1	0.1	0.1	0.2	-0.3
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	0.1
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	-0.1	0.1
Stereotopy head waving duration, day 3	0.1	0.1	0.1	-0.3	0.3
Locomotion velocity, session 7	0.1	0.1	0.2	0.3	-0.4
Locomotion distance, session 7	0.6	0.7	0.7	0.9	-0.8
Stereotopy head waving bouts, day 7	1.5	1.7	1.9	-1.4	1.2
Stereotopy head waving duration, day 7	0.5	0.7	0.8	-0.9	0.7
Locomotion velocity, session 8	1.1	1.3	1.5	-1.2	1.1
Locomotion distance, session 8	0.5	0.7	0.7	-0.8	0.8
Degree of sensitization distance	0.3	0.3	0.3	0.5	-0.5
Degree of sensitization stereotypy	0.4	0.4	0.5	-0.7	0.6
Conditioned locomotion	1.3	1.5	1.6	-1.3	1.2
Cocaine response after cond. corrected	1.0	1.1	1.3	0.9	-1.1
Cocaine response after cond. not corrected	2.4	2.7	3.0	1.5	-1.7
Cocaine response before conditioning	1.7	2.0	2.2	1.5	-1.4
Saline control response	0.0	0.0	0.0	-0.0	-0.1
Bone: connectivity density	0.3	0.5	0.6	-0.7	0.7
Bone: cortical apparent density	6.3	8.3	8.3	-2.9	2.9
Bone: cortical area	0.2	0.2	0.2	-0.5	0.5
Bone: cortical porosity	0.4	0.4	0.4	-0.6	0.7
Bone: cortical porosity	0.0	0.0	0.0	-0.2	0.2
Bone: cortical thickness	0.1	0.2	0.3	-0.5	0.4
Bone: cortical thickness	0.7	0.8	0.9	-0.9	0.9
Bone: cortical tissue density	6.4	8.5	8.6	-2.9	2.9
Condit. Reinf. active minus inactive responses	0.6	0.7	0.8	0.8	-0.9
Condit. Reinf. active-inactive response ratio	2.4	2.6	2.7	1.6	-1.6
Condit. Reinf. active responses	0.2	0.2	0.3	0.3	-0.5
Condit. Reinf. inactive responses	1.3	1.5	1.8	-1.3	1.2
Incentive salience index mean	0.5	0.6	0.8	0.7	-0.9
Condit. Reinf. lever presses	0.1	0.2	0.2	0.3	-0.5
Condit. Reinf. active minus inactive responses	0.8	1.0	1.0	-1.0	1.0
Condit. Reinf. active-inactive response ratio	0.7	0.7	0.8	-0.8	0.9
Condit. Reinf. active responses	0.0	0.1	0.1	-0.2	0.3
Condit. Reinf. inactive responses	0.4	0.5	0.6	0.7	-0.8
Condit. Reinf. lever presses	0.7	0.9	1.1	1.1	-0.9
Condit. Reinf. lever reinforcers received	0.1	0.2	0.2	-0.4	0.5
Conditioned reinforcement - actives	1.9	1.9	1.9	-1.3	1.4
Conditioned reinforcement - inactives	0.6	0.7	0.7	-0.8	0.8
Conditioned locomotion	0.2	0.2	0.2	0.4	-0.5
Patch foraging indifference point 0 sec	4.0	6.5	7.0	-2.7	2.4
Patch foraging indifference point AUC	1.8	2.1	2.6	-1.6	1.2
Delay disc. indifference point, 0s delay	0.4	0.5	0.5	-0.7	0.6
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.3	-0.2
Delay disc. indifference point, 2s delay	0.4	0.5	0.6	0.8	-0.6
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	0.5	-0.4
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	-0.5	0.6
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.0	0.1
Indifference point function ln k	1.4	1.9	2.1	-1.3	1.5
Indifference point function log k	1.4	1.9	2.1	-1.3	1.5
Patch foraging total patch changes 0 sec	4.8	7.7	8.4	-2.9	2.6
Patch foraging total patch changes 12 sec	4.1	5.3	5.5	-2.4	2.3
Patch foraging total patch changes 18 sec	1.1	1.4	1.7	-1.3	1.1
Patch foraging total patch changes 24 sec	0.2	0.3	0.4	-0.6	0.4
Patch foraging total patch changes 6 sec	1.9	2.8	3.5	-1.9	1.5
Patch foraging time to switch 0 sec	8.8	13.6	14.2	3.8	-3.6
Patch foraging water rate 0 sec	15.0	24.0	24.7	-5.0	4.8
Patch foraging water rate 12 sec	9.8	15.0	15.7	-3.8	4.0
Patch foraging water rate 18 sec	5.0	6.7	6.9	-2.5	2.6
Patch foraging water rate 24 sec	3.7	5.2	5.5	-2.2	2.3
Patch foraging water rate 6 sec	4.1	6.0	6.0	-2.4	2.5
Seeking ratio, delayed vs. immediate footshock	0.6	0.6	0.7	-0.8	0.8
Distance traveled before self-admin	1.1	1.2	1.2	1.1	-1.1
Distance traveled after self-admin	0.4	0.4	0.5	-0.6	0.7
Extensor digitorum longus weight	7.9	31.1	32.9	-5.7	5.4
Bone: elastic displacement	0.4	0.4	0.5	-0.6	0.7
Bone: elastic work	0.0	0.0	0.1	0.0	0.2
Bone: endosteal estimation	0.1	0.2	0.3	0.5	-0.2
Bone: endosteal perimeter	0.0	0.1	0.1	0.3	-0.2
Epididymis fat weight	3.2	7.6	7.7	2.7	-2.8
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.2	0.3
Delta time in open arm before/after self-admin	0.3	0.3	0.4	-0.7	0.4
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.2	-0.4
Delay discount exponential model param	0.0	0.0	0.0	-0.0	-0.0
Extinction: sum of active levers before priming	0.4	0.4	0.5	0.5	-0.7
Active lever presses in extinction session 6	1.3	1.2	1.3	-1.1	1.1
Bone: final force	0.2	0.3	0.5	-0.4	0.7
Bone: final moment	0.3	0.4	0.6	-0.5	0.8
Food consumed during 24 hour testing period	0.6	0.7	0.7	-0.9	0.8
Glucose	0.2	0.2	0.3	-0.5	0.5
Heart weight	0.0	0.0	0.0	0.1	0.1
Delay discount hyperbolic model param	0.0	0.0	0.0	-0.1	0.1
Intermittent access intake day 1-15 change	1.6	1.6	1.7	1.2	-1.3
Intermittent access intake escalation	1.6	1.6	1.7	1.2	-1.3
Intermittent access intake escalation 2	0.4	0.4	0.5	0.6	-0.7
Intermitt. access day 1 inactive lever presses	3.3	3.5	3.7	-1.9	1.8
Intermitt. access day 15 inactive lever presses	1.2	1.3	1.3	-1.2	1.1
Intermitt. access escalation Index	0.2	0.2	0.3	-0.4	0.5
Intermittent access day 1 total infusions	0.1	0.1	0.1	0.2	-0.3
Intermittent access day 15 total infusions	1.4	1.6	1.6	1.2	-1.3
Intermittent access terminal intake (last 3 days)	1.6	1.8	1.9	1.3	-1.4
Intermittent access total infusions	0.3	0.3	0.4	0.5	-0.6
Intermittent access day 1 locomotion	0.3	0.3	0.3	0.5	-0.5
Intermittent access day 15 total locomotion	0.0	0.0	0.1	0.2	-0.2
Intermittent access total locomotion	0.1	0.1	0.1	0.3	-0.3
Intermittent access standard deviation	3.0	3.2	3.6	1.7	-1.9
Left kidney weight	2.1	6.0	6.1	-2.5	2.4
Right kidney weight	1.4	3.9	4.0	-1.9	2.0
Cocaine induced anxiety	1.2	1.3	1.5	-1.1	1.2
Post-drug Anxiety	0.6	0.7	0.8	-0.8	0.9
Baseline Anxiety	1.4	1.4	1.5	1.2	-1.2
Tail length	4.2	12.7	13.5	-3.7	3.5
Length with tail	6.8	24.8	26.6	-5.2	4.8
Length without tail	3.8	8.2	9.0	-3.0	2.7
Times rat made contact with spout	0.1	0.1	0.1	-0.3	0.2
Lifetime Intake	0.1	0.1	0.1	0.3	-0.3
Liver weight, left	1.9	3.0	3.1	-1.8	1.7
Liver weight, right	0.0	0.1	0.1	-0.3	0.1
Locomotor activity	0.2	0.4	0.4	-0.6	0.6
Locomotor testing distance	0.4	0.7	0.7	-0.8	0.8
Locomotor testing rearing	1.5	2.4	2.4	1.6	-1.5
Locomotion in novel chamber	6.0	7.4	7.5	-2.7	2.7
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	0.1	-0.0
Fecal boli incidents, locomotor time 1	2.5	2.7	3.2	1.5	-1.8
Change in fecal boli incidents, locomotor task	2.8	2.7	2.8	-1.6	1.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.0	-0.4
Bouts of movement, locomotor time 1	1.4	1.5	1.7	1.2	-1.3
Total resting periods, locomotor time 1	1.3	1.4	1.5	1.2	-1.2
Rest time, locomotor task time 1	0.0	0.0	0.0	0.2	-0.1
Distance moved, locomotor task time 1	0.1	0.2	0.2	0.5	-0.3
Vertical activity count, locomotor time 1	0.3	0.3	0.5	-0.5	0.7
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.5	-0.7	0.4
Bouts of movement, locomotor time 2	1.9	2.1	2.4	-1.3	1.5
Total resting periods, locomotor time 2	1.5	1.6	1.9	-1.1	1.4
Rest time, locomotor task time 2	0.1	0.1	0.1	-0.3	0.4
Distance moved, locomotor task time 2	0.3	0.3	0.4	0.6	-0.5
Vertical activity count, locomotor time 2	0.1	0.1	0.2	-0.3	0.4
Light reinforcement 1	0.0	0.0	0.0	-0.1	0.1
Light reinforcement 2	1.9	2.5	2.6	1.6	-1.6
Bone: marrow area	0.1	0.1	0.3	0.5	-0.1
Bone: maximum diameter	0.2	0.4	0.4	0.6	-0.7
Bone: maximum force	0.1	0.2	0.3	-0.4	0.6
Bone: maximum moment	0.2	0.3	0.3	-0.4	0.6
Mean time between licks in bursts	0.4	0.6	0.6	0.8	-0.7
Mean num. licks in bursts	0.1	0.1	0.2	-0.4	0.2
Cd content in liver	2.6	2.9	3.2	-1.6	1.8
Co content in liver	1.6	1.9	2.0	-1.4	1.4
Cu content in liver	2.1	2.6	2.7	1.7	-1.6
Fe content in liver	0.5	0.6	0.7	0.8	-0.7
K content in liver	0.1	0.1	0.1	-0.4	0.2
Mg content in liver	0.1	0.1	0.1	-0.3	0.4
Mn content in liver	0.6	0.7	0.7	-0.8	0.9
Na content in liver	0.5	0.6	0.7	0.7	-0.8
Rb content in liver	1.2	1.4	1.6	-1.1	1.3
Se content in liver	0.0	0.0	0.0	0.1	-0.1
Sr content in liver	0.4	0.4	0.5	-0.6	0.7
Zn content in liver	0.1	0.1	0.1	-0.2	0.3
Bone: minimum diameter	0.8	1.5	1.6	-1.2	1.3
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.0	-0.0
Time in novel zone, hab. session 1	0.5	0.5	0.5	0.7	-0.6
Total zone transitions, hab. session 1	0.1	0.1	0.1	0.4	-0.2
Total locomotion distance, hab. session 1	0.7	1.0	1.2	-0.9	1.1
Locomotion velocity, hab. session 1	1.2	1.7	1.9	-1.2	1.4
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.1	-0.3
Time in novel zone, hab. session 2	0.2	0.2	0.2	0.5	-0.4
Total zone transitions, hab. session 2	0.7	0.9	1.0	0.9	-1.0
Total locomotion distance, hab. session 2	0.3	0.4	0.4	-0.6	0.6
Locomotion velocity, hab. session 2	0.4	0.6	0.6	-0.8	0.7
Novel to familiar place preference ratio	0.7	0.7	0.7	0.8	-0.9
Novelty place preference	0.4	0.4	0.5	0.7	-0.7
Time in novel zone, NPP test	0.2	0.2	0.2	0.5	-0.5
Total zone transitions, NPP test	0.2	0.2	0.3	-0.6	0.4
Total locomotion distance, NPP test	0.4	0.6	0.6	-0.8	0.8
Locomotion velocity, NPP test	0.4	0.6	0.6	-0.7	0.8
Intraocular pressure	0.1	0.1	0.1	0.3	-0.2
Delta distance traveled before/after self-admin	1.1	1.1	1.2	-1.0	1.1
Delta ambulatory time before/after self-admin	2.6	2.8	2.9	-1.7	1.7
Parametrial fat weight	0.0	0.1	0.1	0.3	-0.2
Pavlov. Cond. lever latency	0.6	0.8	0.9	-0.8	1.0
Pavlov. Cond. magazine entry latency	0.4	0.5	0.5	0.6	-0.7
Pavlov. Cond. change in total contacts	0.2	0.3	0.3	0.4	-0.6
Pavlov. Cond. index score	0.9	1.1	1.3	1.0	-1.1
Pavlov. Cond. latency score	0.7	0.8	1.0	0.8	-1.0
Pavlov. Cond. lever contacts	1.3	1.5	1.7	1.2	-1.3
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	-0.8	0.9
Pavlov. Cond. intertrial magazine entries	6.1	7.4	8.1	-2.8	2.6
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.1	0.9	-1.0
Pavlov. Cond. response bias	0.9	1.0	1.3	0.9	-1.1
Pavlov. Cond. lever latency	1.4	1.8	2.1	-1.5	1.2
Pavlov. Cond. magazine entry latency	3.6	4.2	4.3	2.1	-2.0
Pavlov. Cond. change in total contacts	4.0	5.6	6.1	2.5	-2.3
Pavlov. Cond. index score	3.3	4.2	4.5	2.1	-2.0
Pavlov. Cond. latency score	3.5	4.4	4.6	2.1	-2.0
Pavlov. Cond. lever contacts	2.1	2.9	3.2	1.8	-1.6
Pavlov. Cond. magazine entry number	2.8	3.5	3.6	-1.9	1.8
Pavlov. Cond. intertrial magazine entries	5.0	6.5	6.7	-2.6	2.5
Pavlov. Cond. lever-magazine prob. diff.	3.9	5.0	5.3	2.3	-2.2
Pavlov. Cond. response bias	2.4	3.2	3.5	1.9	-1.7
Time in closed arm before self-admin	5.0	5.7	6.1	2.5	-2.3
Time in closed arm after self-admin	1.4	1.4	1.9	1.4	-1.0
Time in open arm before self-admin	6.4	7.0	7.0	-2.6	2.6
Time in open arm after self-admin	4.2	4.6	5.3	-2.3	2.0
Bone: periosteal estimation	0.0	0.0	0.1	0.0	0.2
Bone: periosteal perimeter	0.0	0.0	0.0	0.2	-0.1
Bone: post-yield work	2.4	3.2	3.2	-1.8	1.8
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.1	0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	0.1	-0.0
Progressive ratio test 1 inactive lever presses	3.4	3.8	3.8	-1.9	1.9
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.0	0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.2	0.2
Progressive ratio test 2 inactive lever presses	0.7	0.8	0.9	-0.8	0.9
Incentive Sensitization - Responses	0.0	0.0	0.0	0.0	0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.1	0.2
Sum of active levers in priming session hrs 5-6	1.1	1.1	1.2	1.0	-1.1
Progressive ratio	0.1	0.1	0.2	-0.1	0.5
Food seeking constrained by brief footshock	0.6	0.7	0.8	-0.8	0.9
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.5	0.2
Retroperitoneal fat weight	0.2	0.6	0.7	0.7	-0.9
Reaction time number correct	3.1	4.5	4.8	-2.2	2.0
Reaction time mean minus median	0.0	0.0	0.0	0.1	-0.1
Reaction time mean minus median AUC	0.0	0.0	0.0	-0.1	0.1
Reaction time num false alarms	1.0	1.4	1.5	-1.2	1.1
Reaction time num false alarms AUC	1.3	1.8	1.9	-1.4	1.3
Reaction time trials correct on left	3.1	4.5	4.8	-2.2	2.0
Reaction time trials on left	3.2	4.6	4.9	-2.2	2.1
Reaction time mean	0.4	0.6	0.8	0.9	-0.7
Reaction time mean AUC	0.2	0.2	0.3	0.5	-0.4
Median of all reaction times	0.2	0.2	0.3	0.6	-0.3
Reaction time omissions	1.6	2.1	2.2	-1.4	1.5
Reaction time false alarm rate	0.1	0.1	0.1	-0.3	0.3
Reaction time premature initiation rate	0.5	0.7	0.8	-0.8	0.9
Reaction time premature initiations	2.2	3.1	3.2	-1.8	1.7
Std. dev. reaction times	0.2	0.2	0.3	0.5	-0.4
Reaction time trials completed	3.2	4.6	4.9	-2.2	2.1
Reaction time trials AUC	3.3	4.8	5.1	-2.3	2.1
Run reversals in cocaine runway, females	1.8	1.8	1.9	1.4	-1.3
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.3	0.4
Latency to leave start box in cocaine runway	0.4	0.5	0.5	0.7	-0.7
Latency to leave start box in cocaine runway, F	0.8	0.9	1.0	0.9	-1.0
Latency to leave start box in cocaine runway, M	0.3	0.3	0.3	0.5	-0.5
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.2	0.1
Total sessions with >9 infusions	0.0	0.0	0.0	-0.0	0.0
Short access day 1 total inactive lever presses	0.1	0.1	0.1	-0.2	0.3
Short access day 10 total inactive lever presses	1.0	1.1	1.2	-1.0	1.1
Short access day 1 total infusions	0.3	0.3	0.4	-0.5	0.6
Short access day 10 total infusions	0.1	0.2	0.2	0.4	-0.4
Short access total infusions	0.1	0.1	0.1	0.4	-0.2
Short access day 1 locomotion	0.2	0.2	0.2	0.5	-0.5
Short access day 10 total locomotion	0.2	0.3	0.3	0.4	-0.6
Short access total locomotion	0.0	0.0	0.0	0.1	-0.0
One hour access (0.3 mA shock)	0.1	0.2	0.2	-0.5	0.3
Compulsive drug intake	0.0	0.0	0.0	-0.1	-0.0
One hour access (shock baseline)	0.0	0.0	0.0	0.1	-0.1
Social response proportion	0.3	0.3	0.4	-0.3	0.7
Social responses	0.0	0.0	0.0	0.2	-0.0
Social time	1.6	2.1	2.6	-1.3	1.6
Soleus weight	0.2	0.7	1.1	-1.0	0.6
Bone: stiffness	1.4	2.3	2.3	-1.5	1.5
Tibialis anterior weight	0.5	1.6	1.9	-1.4	1.2
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.2	-1.1	0.8
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.1	-0.4	0.2
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.2	0.2
Time to tail flick, test, after self-admin	2.2	2.3	2.6	-1.6	1.4
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.1	0.1
Delta time to tail flick, test, before/after SA	1.8	1.7	2.0	-1.4	1.2
Tibia length	0.0	0.1	0.1	-0.3	0.3
Ambulatory time before self-admin	1.6	1.7	1.8	1.3	-1.3
Ambulatory time after self-admin	0.1	0.1	0.1	0.3	-0.2
Bone: tissue strength	0.1	0.1	0.1	0.3	-0.2
Total heroin consumption	0.2	0.3	0.4	-0.7	0.4
Bone: trabecular number	0.2	0.3	0.3	-0.6	0.6
Bone: trabecular spacing	0.1	0.1	0.1	0.3	-0.4
Bone: trabecular thickness	0.0	0.0	0.0	-0.2	0.2
Bone: trabecular tissue density	0.0	0.0	0.0	0.1	-0.1
Water consumed over 24 hours	2.6	3.1	3.3	-1.7	1.8
Number of responses in last shaping day	0.3	0.4	0.4	0.6	-0.5