Hub : Genes

Adcy9

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative TSS XM_039085849.1 0.06 0.03 6.7e-05 0.04 0.04 0.03 0.04 1.0e-05 1.3e-05 2.6e-04 6.2e-05
2 IL intron excision ratio chr10_11141546_11222937 0.16 0.09 7.2e-03 0.14 0.05 0.08 0.1 3.8e-04 2.2e-02 6.1e-03 2.3e-03
3 Brain mRNA stability Adcy9 0.26 0.1 1.1e-07 0.08 0.07 0.08 0.07 1.5e-07 3.0e-07 7.7e-08 2.3e-07
4 NAcc mRNA stability Adcy9 0.07 0.04 1.4e-05 0.05 0.04 0.03 0.04 6.5e-07 3.5e-05 7.5e-05 2.3e-05
5 PL mRNA stability Adcy9 0.14 0.05 1.1e-11 0.1 0.12 0.13 0.14 6.2e-11 1.4e-13 2.4e-14 5.8e-15
6 Adipose mRNA stability Adcy9 0.06 0.04 9.1e-05 0.03 0.03 0.02 0.03 9.2e-05 1.5e-04 2.2e-03 3.4e-04
7 IL intron excision ratio chr10_11223127_11234338 0.23 0.11 6.7e-04 0.06 0.1 0.11 0.09 1.3e-02 2.1e-03 1.5e-03 3.9e-03
8 Adipose gene expression Adcy9 0.09 0.05 2.6e-07 0.06 0.06 0.06 0.06 6.5e-07 2.4e-07 1.2e-07 1.3e-07
9 Liver isoform ratio XM_039085849.1 0.03 0.02 2.1e-03 0.01 0.02 0.01 0.02 1.1e-02 1.7e-03 8.3e-03 5.2e-03
10 NAcc gene expression Adcy9 0.06 0.03 5.5e-04 0.04 0.01 0.03 0.01 9.0e-06 7.0e-03 5.4e-04 5.9e-02
11 PL gene expression Adcy9 0.14 0.07 9.9e-04 0.01 0.04 0.03 0.02 7.1e-03 7.6e-05 1.7e-04 4.6e-03
12 Brain gene expression Adcy9 0.48 0.07 1.0e-13 0.14 0.19 0.22 0.2 5.3e-13 1.2e-17 4.3e-20 2.7e-18
13 IL mRNA stability Adcy9 0.25 0.13 8.0e-03 0.07 0.01 -0 0.01 1.1e-02 1.7e-01 3.9e-01 2.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.40.72.80.8-0.70.90.7-0.80.60.8-0.7-0.81.7-0.8-0.50.0
Area under the delay curve0.00.00.1-0.0-0.0-0.1-0.00.2-0.10.0-0.40.20.10.1-0.00.3
BMI with tail0.41.26.0-0.70.8-0.0-0.70.3-0.5-0.2-1.90.22.4-1.2-0.31.5
BMI without tail1.12.311.40.5-0.11.20.1-1.10.60.8-2.4-0.73.4-2.0-0.92.0
Body weight1.25.08.52.9-2.72.52.8-2.92.92.80.7-2.0-0.10.5-1.61.6
Weight adjusted by age2.42.85.7-2.41.9-1.8-1.72.0-1.8-1.7-1.51.61.70.10.8-1.4
Bone surface0.20.30.90.5-0.50.30.5-0.60.40.7-0.0-0.60.60.4-0.90.4
Bone volume0.30.52.70.5-0.40.50.4-0.60.40.6-0.8-0.51.7-0.3-0.80.4
Breakpoint value in progressive ratio session0.80.93.9-0.70.5-1.3-0.50.4-0.4-0.2-0.70.30.22.0-2.00.6
Number of licking bursts0.20.21.30.0-0.20.00.30.2-0.20.1-1.0-0.11.1-0.2-0.30.1
Context. condit. distance diff. score0.10.10.20.20.2-0.3-0.30.4-0.2-0.4-0.20.4-0.10.4-0.4-0.2
Locomotion velocity, session 10.20.21.0-0.60.6-0.0-0.60.1-0.2-0.7-0.31.0-0.50.2-0.30.1
Locomotion distance, session 10.10.10.6-0.10.1-0.30.00.10.10.2-0.40.00.30.8-0.5-0.4
Locomotion velocity, session 20.60.71.9-0.90.8-0.8-0.80.5-0.7-0.7-0.21.0-0.61.4-1.20.2
Locomotion distance, session 20.40.52.6-0.50.3-0.2-0.20.2-0.2-0.10.60.4-1.21.6-0.4-1.2
Locomotion velocity, session 30.20.20.70.4-0.50.50.5-0.60.80.50.1-0.3-0.1-0.0-0.0-0.2
Locomotion distance, session 30.10.10.5-0.30.1-0.60.10.5-0.3-0.1-0.4-0.00.50.1-0.1-0.7
Stereotopy head waving bouts, day 30.81.02.30.9-0.81.00.8-0.81.01.11.3-1.5-0.2-1.30.6-1.0
Stereotopy head waving duration, day 30.60.72.21.0-0.70.70.7-0.70.81.11.1-1.5-0.2-1.10.5-0.2
Locomotion velocity, session 71.21.36.40.3-0.30.60.30.20.40.31.4-0.4-1.0-0.52.5-2.5
Locomotion distance, session 70.81.04.9-0.60.5-0.1-0.40.9-0.6-0.70.40.40.1-0.92.2-2.0
Stereotopy head waving bouts, day 70.20.20.7-0.10.5-0.3-0.50.7-0.6-0.70.60.3-0.8-0.10.2-0.5
Stereotopy head waving duration, day 70.10.10.50.4-0.10.10.0-0.10.1-0.00.5-0.1-0.70.0-0.4-0.1
Locomotion velocity, session 81.31.65.8-1.00.9-1.2-1.01.1-1.0-1.3-0.11.7-1.22.4-1.2-0.6
Locomotion distance, session 80.50.73.6-0.10.4-0.5-0.50.6-0.3-0.50.30.7-1.31.9-0.5-1.0
Degree of sensitization distance0.30.31.80.2-0.10.50.0-0.00.10.00.7-0.1-0.1-0.81.4-0.7
Degree of sensitization stereotypy0.20.30.7-0.30.5-0.2-0.50.6-0.7-0.90.10.7-0.70.2-0.1-0.4
Conditioned locomotion1.31.53.11.3-1.21.51.1-0.71.01.00.6-1.40.2-1.81.7-1.4
Cocaine response after cond. corrected0.40.41.80.3-0.20.60.30.2-0.1-0.31.20.4-1.30.20.6-0.9
Cocaine response after cond. not corrected0.30.31.00.4-0.30.80.4-0.10.2-0.30.90.4-1.00.00.6-0.7
Cocaine response before conditioning0.70.82.2-0.91.0-0.8-0.90.5-0.6-0.8-1.50.91.20.2-0.60.8
Saline control response0.60.84.6-0.40.6-0.5-0.50.2-0.20.2-2.00.02.20.2-0.70.6
Bone: connectivity density0.40.61.11.0-0.91.00.9-0.80.71.0-0.1-0.91.1-0.6-0.3-0.4
Bone: cortical apparent density0.10.20.60.10.1-0.8-0.00.6-0.20.30.3-0.6-0.10.5-0.2-0.6
Bone: cortical area0.50.83.1-0.50.9-0.5-0.90.2-0.4-0.3-1.80.31.80.3-0.80.8
Bone: cortical porosity3.94.27.12.5-2.62.52.5-2.52.52.71.5-2.6-0.3-0.80.30.4
Bone: cortical porosity2.73.05.32.1-2.12.02.1-2.12.02.21.3-2.3-0.4-0.60.10.3
Bone: cortical thickness1.62.78.2-1.41.7-1.7-1.71.3-1.6-1.2-2.91.32.11.2-1.50.6
Bone: cortical thickness0.91.06.2-0.10.2-0.2-0.20.3-0.3-0.2-2.50.42.5-0.1-0.7-0.3
Bone: cortical tissue density0.10.20.60.2-0.1-0.70.20.4-0.10.40.5-0.8-0.30.4-0.2-0.6
Condit. Reinf. active minus inactive responses0.20.31.50.4-0.30.40.3-0.20.30.20.6-0.0-1.20.8-0.2-0.5
Condit. Reinf. active-inactive response ratio0.40.41.0-0.40.7-0.5-0.80.7-0.6-0.6-0.10.7-0.71.0-0.1-1.0
Condit. Reinf. active responses0.50.63.00.8-0.81.00.8-0.40.50.31.1-0.1-1.70.60.1-0.4
Condit. Reinf. inactive responses0.70.91.81.1-1.31.31.3-0.90.90.81.0-0.7-1.0-0.2-0.00.1
Incentive salience index mean0.60.72.80.8-0.80.80.8-0.50.80.61.2-0.6-1.70.60.5-0.6
Condit. Reinf. lever presses0.60.73.5-0.2-0.1-0.00.20.40.0-0.21.5-0.1-1.9-0.11.6-1.0
Condit. Reinf. active minus inactive responses1.92.45.4-2.22.2-1.7-2.31.5-1.6-1.9-1.11.70.10.9-0.1-0.0
Condit. Reinf. active-inactive response ratio1.31.43.5-1.61.7-1.5-1.91.3-1.2-1.4-0.80.80.8-0.10.30.2
Condit. Reinf. active responses2.63.67.0-2.62.6-1.9-2.61.7-2.0-2.4-1.22.5-0.31.4-0.2-0.3
Condit. Reinf. inactive responses1.31.54.5-1.61.5-0.8-1.41.1-1.4-1.6-1.02.1-0.51.00.0-0.7
Condit. Reinf. lever presses3.54.89.5-3.12.9-2.5-2.92.1-2.3-2.4-2.42.41.01.1-0.5-0.4
Condit. Reinf. lever reinforcers received3.04.38.5-2.92.9-2.0-2.91.9-2.2-2.5-1.52.7-0.11.20.1-0.6
Conditioned reinforcement - actives1.41.42.91.5-1.31.71.4-1.41.41.31.0-1.0-0.9-0.2-0.0-0.4
Conditioned reinforcement - inactives0.20.21.70.5-0.30.40.40.3-0.20.3-0.1-0.3-0.40.50.2-1.3
Conditioned locomotion0.70.82.11.2-1.01.41.1-1.20.91.00.3-0.9-0.2-0.4-0.40.3
Patch foraging indifference point 0 sec0.10.10.8-0.0-0.3-0.20.30.00.10.5-0.2-0.50.40.1-0.3-0.9
Patch foraging indifference point AUC0.70.83.90.4-0.30.20.4-0.50.70.21.00.0-1.92.00.0-0.2
Delay disc. indifference point, 0s delay0.10.10.60.20.20.0-0.10.3-0.20.10.1-0.50.5-0.70.80.3
Delay disc. indifference point, 16s delay0.20.20.8-0.1-0.10.10.10.3-0.10.1-0.1-0.20.5-0.70.9-0.8
Delay disc. indifference point, 2s delay0.80.92.21.5-1.21.11.2-0.90.91.20.2-1.0-0.60.7-0.70.4
Delay disc. indifference point, 24s delay1.00.93.7-1.00.6-1.2-0.51.0-0.5-0.40.30.8-1.11.4-0.2-1.9
Delay disc. indifference point, 4s delay0.20.21.00.4-0.21.00.2-0.30.20.2-0.6-0.00.7-0.80.40.1
Delay disc. indifference point, 8s delay0.10.10.90.1-0.20.10.1-0.1-0.00.1-0.40.20.2-0.3-0.10.9
Indifference point function ln k0.30.52.2-0.50.3-0.5-0.40.6-0.6-0.1-1.20.01.5-1.0-0.10.1
Indifference point function log k0.30.52.2-0.50.3-0.5-0.40.6-0.6-0.1-1.20.01.5-1.0-0.10.1
Patch foraging total patch changes 0 sec0.10.10.40.0-0.3-0.10.3-0.00.10.5-0.2-0.50.5-0.1-0.2-0.6
Patch foraging total patch changes 12 sec0.20.20.90.1-0.30.00.4-0.40.50.50.4-0.4-0.50.9-0.10.2
Patch foraging total patch changes 18 sec0.20.21.9-0.1-0.00.10.10.3-0.4-0.20.10.1-0.40.40.1-1.4
Patch foraging total patch changes 24 sec1.41.73.31.4-1.30.71.4-1.41.31.70.4-1.7-0.61.4-1.81.0
Patch foraging total patch changes 6 sec0.10.21.1-0.30.1-0.6-0.10.3-0.2-0.10.00.1-0.51.1-0.40.2
Patch foraging time to switch 0 sec0.40.52.60.2-0.30.90.3-0.10.1-0.10.40.00.3-1.61.4-1.1
Patch foraging water rate 0 sec0.81.32.9-1.21.5-1.7-1.51.3-1.2-1.1-0.20.8-0.71.3-0.50.1
Patch foraging water rate 12 sec1.01.65.1-0.71.2-1.5-1.31.1-1.2-0.8-0.70.8-0.82.3-1.91.1
Patch foraging water rate 18 sec0.30.41.70.20.3-0.2-0.30.2-0.3-0.20.20.2-0.91.1-1.21.3
Patch foraging water rate 24 sec0.40.61.6-0.30.8-1.3-0.91.3-0.9-0.50.0-0.1-0.71.0-0.60.6
Patch foraging water rate 6 sec0.40.52.2-0.20.6-0.6-0.60.4-0.7-0.4-0.40.6-0.41.0-1.51.0
Seeking ratio, delayed vs. immediate footshock2.93.39.7-1.82.0-1.1-2.12.1-2.1-2.0-0.10.80.6-1.93.1-1.7
Distance traveled before self-admin2.83.06.32.1-1.92.51.9-2.11.61.5-1.0-0.71.7-1.6-1.31.8
Distance traveled after self-admin1.71.94.62.1-1.82.11.8-1.81.61.10.3-0.60.2-1.0-0.30.7
Extensor digitorum longus weight0.41.45.61.2-0.71.20.8-1.11.01.0-0.6-1.02.4-1.6-0.61.2
Bone: elastic displacement1.82.18.9-0.70.6-0.7-0.70.3-0.9-0.6-3.01.12.60.4-2.11.5
Bone: elastic work1.62.110.0-0.40.5-0.4-0.5-0.0-0.7-0.2-3.20.62.60.9-2.41.5
Bone: endosteal estimation1.84.06.22.4-2.42.52.4-2.42.52.22.0-2.1-1.0-1.20.80.1
Bone: endosteal perimeter0.61.33.21.1-0.81.80.7-1.71.41.00.1-0.81.0-1.50.41.1
Epididymis fat weight1.43.310.22.0-1.81.52.0-1.51.91.72.5-1.4-3.21.4-0.3-0.8
Delta time in closed arm before/after self-admin0.80.82.10.6-0.8-0.50.8-0.30.70.81.2-0.9-1.31.4-0.8-0.6
Delta time in open arm before/after self-admin0.50.51.5-0.20.6-0.7-0.71.2-0.9-1.0-0.70.9-0.30.70.2-0.0
Diff in mean of infusions in LGA sessions0.20.20.9-0.30.2-1.0-0.20.3-0.4-0.4-0.20.10.40.1-0.70.9
Delay discount exponential model param0.00.00.1-0.10.10.1-0.0-0.20.0-0.10.3-0.20.2-0.40.2-0.2
Extinction: sum of active levers before priming1.31.34.9-1.61.5-2.2-1.41.6-1.0-0.9-0.50.10.80.50.00.0
Active lever presses in extinction session 60.50.51.9-0.60.7-0.5-0.50.2-0.3-0.2-1.30.11.4-0.4-0.50.8
Bone: final force0.71.22.51.3-1.01.21.1-1.31.01.6-1.0-1.21.3-0.0-0.60.5
Bone: final moment0.71.12.21.2-0.91.01.0-1.21.01.5-1.1-1.11.30.2-0.90.5
Food consumed during 24 hour testing period6.47.718.2-3.43.2-4.3-3.13.5-3.1-2.6-3.02.52.11.3-0.8-0.0
Glucose1.01.53.9-1.20.9-0.3-1.00.8-1.2-1.5-2.01.81.7-1.00.70.1
Heart weight0.30.40.70.8-0.70.60.8-0.70.70.60.6-0.4-0.6-0.2-0.80.2
Delay discount hyperbolic model param0.10.10.2-0.30.3-0.3-0.20.1-0.2-0.30.4-0.10.0-0.20.2-0.2
Intermittent access intake day 1-15 change2.02.03.61.4-1.51.91.4-1.91.61.8-0.8-1.31.2-1.30.01.2
Intermittent access intake escalation1.31.32.61.2-1.21.51.2-1.61.31.4-0.6-1.00.7-0.8-0.01.3
Intermittent access intake escalation 20.80.81.71.0-1.31.11.1-1.11.01.1-0.1-0.6-0.40.3-0.30.6
Intermitt. access day 1 inactive lever presses0.70.71.60.9-0.90.60.9-0.40.51.01.0-1.3-1.11.0-0.20.4
Intermitt. access day 15 inactive lever presses1.11.22.41.4-1.21.31.3-1.11.20.91.5-0.9-1.4-0.20.3-0.3
Intermitt. access escalation Index3.43.05.61.8-2.01.72.0-2.12.31.81.0-1.90.9-2.41.10.6
Intermittent access day 1 total infusions0.20.21.50.4-0.10.50.1-0.20.10.3-0.2-0.4-0.1-0.00.1-1.2
Intermittent access day 15 total infusions0.50.51.30.8-0.61.10.6-1.00.80.9-0.9-0.60.7-0.3-0.20.6
Intermittent access terminal intake (last 3 days)1.11.22.81.3-1.21.61.2-1.71.51.5-0.4-0.90.1-0.1-0.20.3
Intermittent access total infusions0.20.20.50.5-0.30.70.3-0.70.50.5-0.5-0.3-0.00.4-0.70.3
Intermittent access day 1 locomotion0.10.10.30.4-0.00.40.1-0.20.00.3-0.2-0.50.1-0.30.4-0.5
Intermittent access day 15 total locomotion0.40.40.90.9-0.80.60.8-0.90.70.8-0.4-0.40.00.4-0.80.3
Intermittent access total locomotion0.80.91.61.3-1.00.91.1-1.31.01.1-0.5-0.80.10.2-1.00.9
Intermittent access standard deviation1.01.12.21.3-1.21.51.0-1.30.91.2-0.9-0.70.6-0.1-0.71.0
Left kidney weight1.64.47.82.5-2.52.32.6-2.32.72.81.2-2.70.5-1.60.50.6
Right kidney weight1.33.76.22.2-2.41.92.4-1.92.52.42.0-2.2-0.5-1.21.40.3
Cocaine induced anxiety0.50.51.2-0.70.9-0.4-0.80.9-0.8-0.70.60.3-0.60.30.9-1.1
Post-drug Anxiety1.11.25.30.00.0-0.3-0.00.30.2-0.12.1-0.3-2.31.40.6-1.9
Baseline Anxiety0.50.51.90.6-0.80.30.7-0.70.90.40.9-0.1-1.40.7-0.4-0.3
Tail length2.06.011.73.4-3.02.93.1-3.43.33.10.6-2.2-0.10.1-1.50.8
Length with tail3.713.624.04.9-4.73.64.7-4.44.74.33.2-3.2-3.01.8-1.50.0
Length without tail2.55.513.72.5-2.61.32.6-2.02.52.33.3-1.7-3.72.4-0.8-0.4
Times rat made contact with spout1.72.05.4-1.61.1-2.3-1.12.3-1.6-1.2-0.50.70.30.50.8-2.1
Lifetime Intake0.10.10.40.4-0.00.50.1-0.40.30.3-0.4-0.2-0.40.6-0.6-0.2
Liver weight, left0.50.93.30.8-1.00.11.0-0.40.91.01.8-1.6-0.7-0.20.4-0.2
Liver weight, right0.50.74.0-0.30.20.4-0.00.10.10.40.2-0.80.9-1.82.0-0.7
Locomotor activity1.32.14.31.7-1.51.81.6-2.11.81.90.8-1.7-0.3-0.70.00.9
Locomotor testing distance0.91.54.31.1-0.92.10.9-1.71.21.40.2-1.60.5-1.60.70.1
Locomotor testing rearing0.50.73.50.00.01.1-0.00.00.0-0.20.5-0.2-0.4-1.21.7-1.9
Locomotion in novel chamber0.70.94.3-0.90.5-0.8-0.50.6-0.7-0.4-1.60.42.1-1.10.10.9
Locomotion in novel chamber post-restriction0.30.41.20.5-0.80.10.8-0.40.60.90.3-1.1-0.30.5-0.7-0.2
Fecal boli incidents, locomotor time 10.30.32.40.2-0.10.50.3-0.40.60.3-0.40.10.3-0.20.4-1.6
Change in fecal boli incidents, locomotor task0.30.31.00.7-1.00.61.0-0.50.50.60.1-0.30.00.00.10.1
Time >=10cm from walls, locomotor time 11.41.42.71.4-1.41.61.2-1.71.31.3-0.5-0.50.70.1-1.41.4
Bouts of movement, locomotor time 13.84.18.1-2.22.3-1.8-2.42.0-2.5-2.4-2.32.81.01.4-1.40.5
Total resting periods, locomotor time 12.62.95.2-1.71.9-1.5-2.11.7-2.1-2.0-2.02.30.81.1-1.10.5
Rest time, locomotor task time 10.40.41.1-0.70.7-0.6-1.00.7-0.8-0.60.30.2-0.30.6-0.4-1.1
Distance moved, locomotor task time 11.92.14.92.0-2.21.31.9-1.71.91.80.6-1.2-0.3-0.0-0.21.2
Vertical activity count, locomotor time 11.41.43.21.8-1.81.51.5-1.61.51.10.9-0.5-0.7-0.40.00.5
Time >=10cm from walls, locomotor time 21.92.03.71.9-1.81.81.7-1.91.81.60.3-1.40.7-1.2-0.20.7
Bouts of movement, locomotor time 20.10.10.8-0.2-0.20.6-0.2-0.4-0.0-0.1-0.20.40.2-0.3-0.10.9
Total resting periods, locomotor time 20.10.10.5-0.3-0.10.6-0.3-0.1-0.2-0.3-0.10.6-0.0-0.20.10.7
Rest time, locomotor task time 21.41.62.9-1.61.4-1.3-1.61.3-1.6-1.6-0.41.7-0.61.1-0.4-0.4
Distance moved, locomotor task time 21.41.63.21.8-1.61.11.5-1.01.41.51.3-1.8-0.2-0.80.50.3
Vertical activity count, locomotor time 22.22.35.22.3-2.32.01.9-1.51.51.61.2-1.5-0.1-1.10.2-0.7
Light reinforcement 10.10.20.70.1-0.00.6-0.0-0.2-0.0-0.2-0.50.5-0.70.8-0.7-0.0
Light reinforcement 21.01.44.4-0.81.1-1.2-1.01.4-1.2-1.00.90.6-2.11.60.8-0.6
Bone: marrow area1.94.16.42.4-2.42.52.4-2.42.52.32.1-2.2-1.1-1.20.80.1
Bone: maximum diameter0.50.92.9-0.51.1-0.1-1.10.3-0.6-0.8-1.10.81.7-1.10.31.3
Bone: maximum force0.30.51.00.7-0.50.40.6-0.70.61.0-0.6-0.80.90.3-0.50.9
Bone: maximum moment0.20.40.80.5-0.40.10.4-0.60.50.8-0.8-0.60.90.5-0.70.9
Mean time between licks in bursts0.30.41.9-0.30.40.4-0.20.10.0-0.4-0.10.30.6-1.41.1-0.7
Mean num. licks in bursts0.40.51.6-0.50.3-1.1-0.40.8-0.3-0.20.9-0.0-1.00.50.6-1.3
Cd content in liver2.73.09.7-1.71.8-0.9-1.81.4-1.8-1.8-3.12.02.4-0.5-0.60.7
Co content in liver0.40.51.7-0.40.5-1.0-0.50.7-0.6-0.6-0.10.30.20.4-0.91.3
Cu content in liver0.81.02.31.2-1.21.51.3-1.41.11.30.4-0.7-0.30.0-0.5-0.2
Fe content in liver0.81.03.5-0.70.6-0.5-0.60.8-1.1-0.80.41.2-1.81.9-0.2-0.5
K content in liver5.95.810.33.0-3.12.83.2-3.22.93.01.7-2.2-0.8-0.1-0.91.2
Mg content in liver0.90.91.61.2-1.11.01.2-1.31.11.20.4-0.8-0.10.3-1.00.9
Mn content in liver0.50.62.00.8-0.60.20.6-0.60.81.01.1-1.4-0.8-0.10.30.5
Na content in liver2.02.110.60.9-1.00.31.1-0.81.01.03.3-1.4-2.90.80.90.1
Rb content in liver1.72.13.7-1.71.6-1.9-1.61.5-1.7-1.2-1.61.31.40.9-1.1-0.2
Se content in liver0.80.95.20.1-0.1-0.50.1-0.20.20.31.2-0.3-2.32.1-1.00.2
Sr content in liver0.60.61.70.6-0.50.80.5-0.80.50.4-1.0-0.11.3-0.6-0.51.3
Zn content in liver1.92.13.51.8-1.91.71.8-1.81.61.7-0.2-1.10.90.2-1.70.7
Bone: minimum diameter0.20.41.00.7-0.40.60.4-1.01.00.60.5-0.5-0.50.3-0.20.8
Time in familiar zone, hab. session 10.40.31.0-0.60.60.2-0.6-0.2-0.3-0.6-0.81.00.40.1-0.60.9
Time in novel zone, hab. session 10.20.20.50.7-0.70.30.6-0.00.30.40.2-0.5-0.20.00.0-0.5
Total zone transitions, hab. session 11.01.47.8-0.10.2-1.2-0.10.5-0.3-0.30.30.5-1.92.8-2.3-0.0
Total locomotion distance, hab. session 10.91.26.00.4-0.4-0.60.50.00.00.20.80.2-1.92.5-2.10.3
Locomotion velocity, hab. session 10.71.04.50.4-0.4-0.60.50.00.00.20.90.1-1.82.1-1.70.2
Time in familiar zone, hab. session 20.50.61.70.4-0.31.20.3-1.20.80.5-0.1-0.60.8-1.30.40.4
Time in novel zone, hab. session 20.40.41.9-0.1-0.1-0.60.10.4-0.4-0.1-0.70.5-0.01.2-1.41.0
Total zone transitions, hab. session 20.81.12.21.0-1.00.11.2-0.71.11.21.3-1.1-1.51.3-0.7-0.3
Total locomotion distance, hab. session 21.41.94.51.9-2.01.02.1-1.21.41.61.2-1.2-1.00.7-0.80.4
Locomotion velocity, hab. session 21.01.32.81.4-1.60.61.7-0.81.11.21.4-0.9-1.41.0-0.6-0.0
Novel to familiar place preference ratio0.50.51.6-0.40.3-0.6-0.10.6-0.8-0.7-0.21.0-0.81.3-1.00.4
Novelty place preference0.50.51.9-0.20.2-0.5-0.00.5-0.7-0.6-0.21.0-0.71.4-1.20.6
Time in novel zone, NPP test0.80.82.6-0.40.4-0.6-0.20.5-0.9-0.8-0.61.3-0.41.5-1.60.8
Total zone transitions, NPP test0.30.41.7-0.40.6-1.0-0.50.6-0.5-0.2-0.40.5-0.21.3-0.9-0.6
Total locomotion distance, NPP test0.20.20.8-0.20.3-0.9-0.20.8-0.8-0.2-0.10.3-0.20.7-0.4-0.0
Locomotion velocity, NPP test0.20.31.0-0.30.4-1.0-0.31.0-0.9-0.30.20.3-0.50.7-0.1-0.3
Intraocular pressure0.30.41.2-0.70.7-0.4-0.70.6-0.5-0.8-0.40.70.1-0.70.5-1.1
Delta distance traveled before/after self-admin0.80.83.3-0.20.2-0.7-0.20.5-0.1-0.41.6-0.1-1.80.31.4-1.4
Delta ambulatory time before/after self-admin0.91.03.5-0.50.3-0.9-0.30.8-0.3-0.71.30.3-1.90.61.3-1.9
Parametrial fat weight0.71.35.60.8-0.60.20.6-0.20.80.42.3-0.5-2.40.71.1-1.6
Pavlov. Cond. lever latency0.20.20.90.4-0.10.40.0-0.60.40.3-0.50.01.0-0.2-0.10.6
Pavlov. Cond. magazine entry latency0.50.73.1-0.60.3-1.1-0.41.1-0.4-0.51.0-0.4-0.9-0.20.7-1.8
Pavlov. Cond. change in total contacts0.40.42.00.1-0.1-0.40.20.10.40.31.2-0.8-1.40.40.3-0.7
Pavlov. Cond. index score0.40.51.6-0.50.1-0.8-0.20.9-0.4-0.41.0-0.3-1.20.00.4-1.3
Pavlov. Cond. latency score0.50.61.7-0.70.4-0.9-0.41.1-0.7-0.60.8-0.0-1.20.30.3-1.3
Pavlov. Cond. lever contacts0.30.43.0-0.1-0.0-0.30.10.4-0.1-0.11.0-0.2-1.70.8-0.0-0.6
Pavlov. Cond. magazine entry number0.30.41.70.7-0.41.30.5-1.10.60.6-0.30.10.40.1-0.00.9
Pavlov. Cond. intertrial magazine entries0.70.93.11.1-0.70.80.8-1.01.01.31.2-1.8-0.40.00.1-0.2
Pavlov. Cond. lever-magazine prob. diff.0.40.51.7-0.40.1-0.6-0.10.7-0.3-0.21.1-0.4-1.30.10.4-1.3
Pavlov. Cond. response bias0.40.51.3-0.50.3-1.0-0.31.0-0.4-0.40.9-0.3-1.0-0.10.5-1.2
Pavlov. Cond. lever latency3.54.78.22.8-2.72.12.6-2.12.32.32.9-2.5-1.7-0.80.20.6
Pavlov. Cond. magazine entry latency3.84.49.5-2.42.3-3.1-2.32.7-2.4-2.3-1.22.30.02.3-0.4-1.0
Pavlov. Cond. change in total contacts4.96.711.6-3.43.4-2.7-3.32.8-2.9-3.2-2.53.21.01.10.4-0.8
Pavlov. Cond. index score4.96.39.9-3.13.0-2.9-3.02.9-2.9-2.8-2.82.91.61.3-0.2-0.9
Pavlov. Cond. latency score4.86.09.5-3.12.9-2.9-2.92.8-2.8-2.8-2.62.81.51.3-0.1-0.9
Pavlov. Cond. lever contacts2.23.17.1-2.22.2-1.5-2.11.6-1.8-1.8-2.72.02.00.20.0-0.2
Pavlov. Cond. magazine entry number6.07.313.13.3-3.13.63.1-3.13.12.92.5-3.0-0.8-2.61.10.3
Pavlov. Cond. intertrial magazine entries0.10.10.5-0.20.50.7-0.5-0.2-0.4-0.3-0.10.2-0.2-0.5-0.3-0.0
Pavlov. Cond. lever-magazine prob. diff.4.65.99.1-3.02.9-2.9-2.92.8-2.8-2.7-2.62.81.51.3-0.3-0.8
Pavlov. Cond. response bias3.64.97.9-2.82.8-2.3-2.62.3-2.4-2.4-2.82.61.71.0-0.3-0.2
Time in closed arm before self-admin1.82.14.71.7-1.52.21.4-2.01.71.40.2-1.11.2-1.90.3-0.1
Time in closed arm after self-admin2.42.43.51.9-1.81.21.8-1.71.91.91.8-1.6-1.50.9-0.8-0.9
Time in open arm before self-admin0.60.71.7-1.31.1-1.1-1.00.7-0.9-0.6-0.90.40.7-0.0-0.40.6
Time in open arm after self-admin0.70.81.9-0.60.7-0.9-0.71.0-0.9-0.7-1.40.41.3-0.90.50.8
Bone: periosteal estimation0.51.01.81.3-1.01.41.0-1.31.31.20.3-1.00.3-0.70.20.5
Bone: periosteal perimeter0.30.62.30.30.20.8-0.2-0.90.50.2-1.20.31.5-0.2-0.71.1
Bone: post-yield work0.81.05.00.8-0.80.20.7-0.51.00.52.2-0.8-2.00.30.40.6
Progressive ratio test 1 active lever presses0.10.10.5-0.40.7-0.4-0.70.2-0.3-0.1-0.6-0.10.2-0.10.10.3
Progressive ratio test 1 breakpoint0.20.20.6-0.30.7-0.4-0.60.0-0.2-0.0-0.8-0.10.30.3-0.40.7
Progressive ratio test 1 inactive lever presses0.40.51.60.6-0.40.20.5-0.30.40.71.1-1.0-1.30.90.00.2
Progressive ratio test 2 active lever presses1.21.32.51.6-1.21.31.2-1.51.51.40.7-1.2-1.20.5-0.50.3
Progressive ratio test 2 breakpoint1.21.32.61.6-1.21.41.3-1.51.51.50.5-1.3-0.90.1-0.30.3
Progressive ratio test 2 inactive lever presses0.30.32.50.10.30.2-0.30.1-0.20.00.8-0.4-1.60.60.5-0.4
Incentive Sensitization - Responses2.72.76.02.4-2.21.92.2-1.92.01.91.1-1.6-1.00.1-0.50.0
Incentive Sensitization - Breakpoint2.82.85.92.4-2.31.92.2-2.02.12.01.1-1.6-0.90.1-0.5-0.1
Sum of active levers in priming session hrs 5-62.02.07.3-1.81.7-2.7-1.51.9-1.3-1.4-0.70.90.51.1-0.50.3
Progressive ratio0.30.32.3-0.30.10.1-0.1-0.1-0.30.1-0.6-0.30.9-1.50.5-0.1
Food seeking constrained by brief footshock2.12.64.2-1.41.9-1.7-1.91.9-1.7-1.9-0.71.50.11.5-1.32.0
Seeking ratio, punishment vs. effort0.60.72.1-0.40.8-0.8-0.81.0-0.7-0.9-0.10.7-0.01.4-0.91.2
Retroperitoneal fat weight2.37.612.83.3-3.32.33.4-2.93.43.13.6-2.9-2.90.9-0.40.8
Reaction time number correct0.30.41.30.8-0.60.60.50.1-0.10.1-0.5-0.51.1-1.10.60.2
Reaction time mean minus median0.70.94.1-0.50.1-1.1-0.1-0.20.20.10.00.3-0.32.0-1.61.8
Reaction time mean minus median AUC0.60.72.8-0.0-0.4-0.70.3-0.50.60.50.0-0.1-0.11.7-1.51.6
Reaction time num false alarms11.315.327.14.7-5.14.85.0-5.25.15.02.5-4.2-1.0-0.9-0.3-0.0
Reaction time num false alarms AUC10.714.826.84.6-5.04.84.9-5.24.94.92.5-4.0-0.7-1.1-0.10.4
Reaction time trials correct on left0.30.41.30.8-0.60.60.50.1-0.10.1-0.5-0.51.1-1.10.60.2
Reaction time trials on left0.30.41.30.8-0.50.50.50.1-0.10.1-0.5-0.51.2-1.10.50.3
Reaction time mean0.50.82.2-0.90.7-1.0-0.70.5-0.6-0.7-0.71.30.11.5-1.20.5
Reaction time mean AUC0.60.82.7-0.80.7-1.1-0.70.5-0.4-0.6-0.61.1-0.11.7-1.40.6
Median of all reaction times0.60.82.2-0.90.9-0.8-0.90.8-0.9-1.0-1.11.50.50.9-0.90.1
Reaction time omissions0.30.52.4-0.30.1-0.8-0.1-0.20.50.20.3-0.2-0.31.0-1.11.6
Reaction time false alarm rate7.19.920.23.4-4.03.83.9-4.54.34.12.4-3.1-1.2-0.3-0.40.1
Reaction time premature initiation rate1.41.96.01.2-1.31.41.4-1.31.31.31.6-1.0-2.41.5-0.60.1
Reaction time premature initiations1.21.72.81.7-1.71.61.7-1.31.31.51.1-1.3-1.50.9-0.50.3
Std. dev. reaction times0.60.83.90.2-0.7-0.50.7-0.60.70.60.4-0.0-0.72.0-1.51.2
Reaction time trials completed0.30.41.30.8-0.50.50.50.1-0.10.1-0.5-0.51.2-1.10.50.3
Reaction time trials AUC0.30.41.80.7-0.40.50.40.2-0.2-0.0-0.6-0.41.3-1.30.70.1
Run reversals in cocaine runway, females1.00.92.50.6-0.81.00.9-0.70.80.41.2-0.6-0.9-1.31.6-1.1
Run reversals in cocaine runway, males0.20.21.10.5-0.31.00.3-0.30.10.3-0.1-0.2-0.1-0.10.2-0.7
Latency to leave start box in cocaine runway0.30.31.70.1-0.20.10.30.00.1-0.01.00.1-1.31.00.1-0.6
Latency to leave start box in cocaine runway, F0.60.73.3-0.20.1-0.50.00.3-0.0-0.21.00.3-1.71.8-0.3-0.9
Latency to leave start box in cocaine runway, M0.20.20.9-0.00.10.30.00.1-0.2-0.41.00.4-0.8-0.40.80.5
Std. dev. time between licks in bursts0.70.93.2-0.80.8-0.1-0.70.4-0.7-0.8-1.81.11.5-0.7-0.01.1
Total sessions with >9 infusions0.40.51.1-0.71.0-1.0-0.90.9-0.8-0.3-0.5-0.30.40.4-0.1-0.8
Short access day 1 total inactive lever presses0.40.42.40.20.1-0.20.00.4-0.1-0.10.9-0.1-1.51.10.5-0.9
Short access day 10 total inactive lever presses1.61.76.61.4-1.50.91.4-0.81.00.82.6-1.1-2.10.50.80.1
Short access day 1 total infusions0.20.20.50.4-0.20.30.2-0.40.50.40.6-0.5-0.60.50.3-0.7
Short access day 10 total infusions0.40.40.9-0.60.9-0.2-0.80.6-0.8-0.8-0.10.5-0.3-0.40.7-0.9
Short access total infusions0.10.10.60.20.10.50.0-0.40.30.2-0.3-0.0-0.40.40.0-0.8
Short access day 1 locomotion0.30.30.6-0.60.8-0.4-0.80.6-0.7-0.5-0.40.30.3-0.30.70.2
Short access day 10 total locomotion0.10.10.7-0.00.20.1-0.1-0.1-0.20.2-0.8-0.30.6-0.60.10.3
Short access total locomotion0.10.10.3-0.20.4-0.4-0.30.1-0.30.2-0.6-0.40.30.5-0.50.5
One hour access (0.3 mA shock)0.50.62.70.5-0.30.00.3-0.20.10.6-0.7-0.3-0.11.4-1.71.2
Compulsive drug intake0.70.72.0-0.90.8-1.3-0.81.4-1.0-1.0-0.00.60.30.20.7-0.2
One hour access (shock baseline)0.70.93.00.7-0.30.50.3-0.70.40.60.2-0.3-1.31.6-1.71.3
Social response proportion1.51.63.0-1.71.4-1.6-1.41.3-1.2-1.4-1.21.7-0.11.0-0.0-0.9
Social responses0.40.53.00.2-0.20.30.2-0.3-0.00.1-0.40.6-0.91.7-1.20.2
Social time0.60.71.61.2-1.10.71.0-0.80.71.0-0.7-0.20.41.0-1.30.1
Soleus weight2.47.011.83.1-3.03.43.0-3.43.23.40.5-3.11.9-2.3-0.70.9
Bone: stiffness0.30.50.90.8-0.60.80.6-0.60.60.7-0.0-0.60.7-0.90.90.3
Tibialis anterior weight0.61.94.01.6-1.31.91.3-1.71.41.50.2-1.41.4-2.00.00.8
Time to tail flick, vehicle, before self-admin0.20.21.60.30.10.3-0.10.20.1-0.30.8-0.1-0.2-0.41.2-0.1
Time to tail flick, vehicle, after self-admin3.63.87.02.3-2.42.22.3-2.12.72.21.5-2.2-0.6-1.41.2-1.0
Time to tail flick, test, before self-admin0.80.82.80.8-0.61.30.6-0.60.80.1-0.70.11.7-1.70.70.2
Time to tail flick, test, after self-admin0.40.52.0-0.40.4-0.5-0.60.6-0.6-0.8-0.70.90.6-0.30.01.4
Delta time to tail flick, vehicle, before/after SA2.72.65.91.8-2.21.62.1-2.22.42.20.4-1.6-0.0-0.3-0.70.2
Delta time to tail flick, test, before/after SA0.60.61.5-0.90.8-1.2-0.90.9-1.0-0.7-0.60.70.00.6-0.30.5
Tibia length0.10.42.7-0.10.0-0.10.0-0.00.30.40.6-0.8-0.7-0.10.9-1.7
Ambulatory time before self-admin2.72.85.32.0-1.62.31.6-1.91.41.3-1.2-0.52.1-1.7-1.32.0
Ambulatory time after self-admin0.90.92.21.5-1.31.51.3-1.11.00.6-0.1-0.30.6-1.20.00.3
Bone: tissue strength2.12.02.9-1.71.7-1.7-1.71.6-1.7-1.5-1.51.40.41.5-0.7-0.1
Total heroin consumption0.60.73.4-0.60.6-0.6-0.50.3-0.3-0.1-1.60.01.80.0-1.20.3
Bone: trabecular number0.20.42.30.1-0.10.00.1-0.30.10.5-0.8-0.61.5-0.2-1.00.5
Bone: trabecular spacing1.01.22.6-1.31.2-0.5-1.20.9-0.9-1.50.21.6-1.40.11.4-0.9
Bone: trabecular thickness0.20.32.4-0.00.3-0.6-0.20.5-0.10.1-0.6-0.31.5-0.4-0.00.0
Bone: trabecular tissue density0.10.21.50.3-0.3-0.20.4-0.20.30.40.1-0.30.20.2-0.41.2
Water consumed over 24 hours1.31.54.9-1.51.2-2.2-1.21.7-1.4-0.8-1.40.80.71.1-0.3-0.4
Number of responses in last shaping day0.20.21.3-0.10.40.4-0.2-0.20.1-0.00.0-0.40.7-0.81.1-0.2