Adat3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Adat3	0.04	0.03	1.5e-03	0.02	0.02	0.02	0.02	6.3e-03	2.8e-03	4.2e-03	2.2e-03
2	Brain	intron excision ratio	chr7_9110429_9113898	0.03	0.03	2.3e-03	0.02	0.02	0.01	0.02	6.2e-03	2.6e-03	4.3e-02	5.8e-03
3	OFC	gene expression	Adat3	0.15	0.11	1.3e-03	0.13	0.09	0.08	0.09	6.2e-04	3.5e-03	6.2e-03	4.0e-03
4	Brain	intron excision ratio	chr7_9108033_9113898	0.03	0.03	2.7e-03	0.03	0.02	0.02	0.02	2.1e-03	4.8e-03	7.6e-03	5.6e-03
5	PL	gene expression	Adat3	0.02	0.02	2.7e-03	0.02	0.01	0.01	0.02	3.5e-03	1.3e-02	7.2e-02	4.6e-03
6	OFC	isoform ratio	XM_017594558.2	0.21	0.16	6.1e-03	0.04	0.07	0.08	0.09	3.3e-02	1.2e-02	5.8e-03	4.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.7	1.2	4.6	1.0	-0.6	0.6	-0.7	0.7	2.1
Area under the delay curve	2.3	2.4	2.9	-1.2	-1.7	1.6	-1.6	1.7	1.5
BMI with tail	5.7	18.4	22.7	-4.8	-4.6	4.5	-4.5	4.5	2.5
BMI without tail	1.8	3.7	7.2	-2.7	-2.0	1.9	-1.9	1.9	0.3
Body weight	1.0	4.1	4.9	-2.2	-2.2	2.1	-2.1	2.2	1.1
Weight adjusted by age	0.3	0.3	1.1	-1.0	-0.3	0.4	-0.3	0.4	-0.6
Bone surface	1.2	2.0	7.6	2.1	-0.2	0.3	-0.4	0.3	2.8
Bone volume	1.2	2.0	7.5	2.1	-0.2	0.3	-0.4	0.4	2.7
Breakpoint value in progressive ratio session	5.5	6.1	7.1	2.1	2.7	-2.7	2.6	-2.5	-2.3
Number of licking bursts	0.2	0.2	1.0	-0.6	0.1	-0.2	0.1	-0.2	-1.0
Context. condit. distance diff. score	0.2	0.3	0.4	-0.6	-0.5	0.5	-0.6	0.6	0.3
Locomotion velocity, session 1	0.4	0.5	1.5	1.2	0.5	-0.5	0.6	-0.5	0.5
Locomotion distance, session 1	0.3	0.4	1.5	0.9	-0.1	0.1	-0.1	0.2	1.2
Locomotion velocity, session 2	2.5	2.9	6.4	2.5	1.6	-1.6	1.8	-1.6	0.2
Locomotion distance, session 2	1.0	1.4	4.2	2.0	0.9	-1.0	1.1	-1.0	0.6
Locomotion velocity, session 3	5.8	6.8	8.0	2.5	2.8	-2.7	2.8	-2.8	-1.8
Locomotion distance, session 3	0.0	0.0	0.1	-0.1	0.0	-0.1	0.1	0.0	-0.3
Stereotopy head waving bouts, day 3	3.9	4.6	6.3	2.5	2.3	-2.2	2.3	-2.3	-0.9
Stereotopy head waving duration, day 3	4.9	5.9	7.0	2.6	2.6	-2.5	2.6	-2.6	-1.3
Locomotion velocity, session 7	0.6	0.7	1.2	1.1	0.8	-0.8	0.9	-0.8	-0.2
Locomotion distance, session 7	0.1	0.1	0.4	-0.6	-0.1	0.1	-0.0	0.1	-0.6
Stereotopy head waving bouts, day 7	0.3	0.4	1.5	0.6	-0.2	0.3	-0.3	0.2	1.2
Stereotopy head waving duration, day 7	0.4	0.4	1.3	1.1	0.2	-0.1	0.1	-0.1	1.1
Locomotion velocity, session 8	0.5	0.6	1.9	1.4	0.3	-0.3	0.4	-0.4	1.1
Locomotion distance, session 8	0.1	0.1	0.3	0.6	0.2	-0.2	0.3	-0.2	0.3
Degree of sensitization distance	0.3	0.3	0.4	-0.6	-0.6	0.6	-0.6	0.6	0.4
Degree of sensitization stereotypy	2.3	2.5	3.7	-0.8	-1.6	1.6	-1.7	1.6	1.9
Conditioned locomotion	1.1	1.3	3.8	-1.9	-1.0	1.1	-0.9	1.0	-0.3
Cocaine response after cond. corrected	3.8	4.3	8.9	-3.0	-2.1	2.0	-2.0	2.1	0.3
Cocaine response after cond. not corrected	4.1	4.6	10.1	-3.2	-2.1	2.1	-2.0	2.1	0.2
Cocaine response before conditioning	0.3	0.4	0.7	0.8	0.7	-0.6	0.6	-0.7	-0.1
Saline control response	0.0	0.1	0.2	-0.4	-0.2	0.2	-0.0	0.2	-0.2
Bone: connectivity density	0.8	1.3	3.9	0.3	-0.9	1.0	-1.0	1.0	2.0
Bone: cortical apparent density	0.7	0.9	1.1	-1.0	-1.0	1.0	-1.0	1.0	0.5
Bone: cortical area	0.9	1.3	2.9	-0.0	-1.1	1.1	-1.1	1.2	1.7
Bone: cortical porosity	0.4	0.4	1.2	1.1	0.6	-0.6	0.5	-0.6	0.1
Bone: cortical porosity	0.2	0.2	0.8	0.7	-0.1	0.1	-0.3	0.1	0.9
Bone: cortical thickness	1.2	1.9	2.3	-0.9	-1.5	1.5	-1.5	1.5	1.3
Bone: cortical thickness	0.1	0.2	0.5	-0.3	0.2	-0.3	0.3	-0.3	-0.7
Bone: cortical tissue density	0.4	0.6	0.8	-0.9	-0.8	0.8	-0.8	0.8	0.4
Condit. Reinf. active minus inactive responses	3.7	4.1	4.8	2.1	2.2	-2.2	2.1	-2.1	-1.3
Condit. Reinf. active-inactive response ratio	2.2	2.4	2.8	1.2	1.7	-1.7	1.6	-1.7	-1.4
Condit. Reinf. active responses	2.8	3.4	5.7	2.4	1.9	-1.9	1.9	-1.9	-0.6
Condit. Reinf. inactive responses	0.5	0.6	1.9	1.4	0.7	-0.7	0.7	-0.6	0.4
Incentive salience index mean	1.6	2.0	3.6	1.9	1.5	-1.5	1.4	-1.4	-0.3
Condit. Reinf. lever presses	0.4	0.6	2.1	0.9	-0.3	0.2	-0.4	0.4	1.4
Condit. Reinf. active minus inactive responses	2.7	3.3	3.8	1.3	1.9	-1.9	1.8	-1.9	-1.9
Condit. Reinf. active-inactive response ratio	0.6	0.6	2.2	-0.3	0.6	-0.7	0.6	-0.6	-1.5
Condit. Reinf. active responses	2.2	3.0	3.5	1.7	1.9	-1.9	1.8	-1.8	-1.3
Condit. Reinf. inactive responses	1.0	1.2	2.2	1.5	1.2	-1.1	1.0	-1.1	-0.2
Condit. Reinf. lever presses	2.6	3.5	4.0	1.4	2.0	-2.0	2.0	-2.0	-1.8
Condit. Reinf. lever reinforcers received	1.8	2.5	2.9	1.3	1.7	-1.7	1.6	-1.7	-1.4
Conditioned reinforcement - actives	2.1	2.1	2.8	1.6	1.6	-1.7	1.3	-1.3	-1.1
Conditioned reinforcement - inactives	0.4	0.5	1.0	-1.0	-0.6	0.6	-0.7	0.8	-0.0
Conditioned locomotion	6.9	8.2	10.5	3.0	3.1	-3.2	2.8	-2.8	-2.2
Patch foraging indifference point 0 sec	0.2	0.3	0.4	-0.3	-0.5	0.6	-0.5	0.5	0.7
Patch foraging indifference point AUC	1.0	1.1	1.4	0.9	1.1	-1.2	1.0	-1.0	-1.1
Delay disc. indifference point, 0s delay	8.6	9.5	11.6	-2.0	-3.1	3.2	-3.2	3.3	3.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.2	-0.4	0.4	-0.4	0.4	0.4
Delay disc. indifference point, 2s delay	6.3	7.0	8.1	-2.1	-2.7	2.8	-2.8	2.8	2.5
Delay disc. indifference point, 24s delay	0.4	0.4	0.6	-0.8	-0.8	0.6	-0.7	0.5	0.3
Delay disc. indifference point, 4s delay	1.4	1.5	2.5	-0.6	-1.2	1.3	-1.2	1.3	1.6
Delay disc. indifference point, 8s delay	0.9	0.9	1.4	-1.2	-1.0	1.0	-1.0	1.0	0.4
Indifference point function ln k	0.2	0.3	0.3	-0.5	-0.5	0.5	-0.5	0.6	0.4
Indifference point function log k	0.2	0.3	0.3	-0.5	-0.5	0.5	-0.5	0.6	0.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.2	-0.3	-0.4	0.5	-0.4	0.4	0.5
Patch foraging total patch changes 12 sec	0.3	0.3	1.1	-1.1	-0.4	0.5	-0.4	0.4	-0.4
Patch foraging total patch changes 18 sec	1.1	1.4	1.6	1.1	1.2	-1.2	1.3	-1.3	-0.9
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	0.2	0.3	-0.3	0.2	-0.3	-0.2
Patch foraging total patch changes 6 sec	0.2	0.3	0.4	0.6	0.5	-0.5	0.6	-0.6	-0.1
Patch foraging time to switch 0 sec	1.9	3.0	4.7	-0.9	-1.7	1.9	-1.6	1.7	2.2
Patch foraging water rate 0 sec	0.4	0.6	2.2	-0.5	0.5	-0.7	0.3	-0.5	-1.5
Patch foraging water rate 12 sec	0.7	1.0	3.3	-1.8	-0.8	0.7	-0.7	0.7	-0.7
Patch foraging water rate 18 sec	1.3	1.7	6.3	-0.9	0.8	-1.0	0.8	-1.0	-2.5
Patch foraging water rate 24 sec	0.8	1.1	3.8	-1.7	-0.0	-0.2	-0.0	-0.1	-1.9
Patch foraging water rate 6 sec	1.0	1.4	3.8	-0.1	1.0	-1.2	1.1	-1.1	-2.0
Seeking ratio, delayed vs. immediate footshock	3.9	4.5	6.8	2.6	2.2	-2.2	2.1	-2.2	-1.0
Distance traveled before self-admin	0.5	0.5	0.9	-0.3	-0.7	0.6	-0.9	0.9	0.7
Distance traveled after self-admin	0.5	0.6	1.2	1.1	0.8	-0.8	0.8	-0.7	-0.2
Extensor digitorum longus weight	3.8	14.9	21.2	-4.6	-4.1	3.9	-4.2	4.1	1.4
Bone: elastic displacement	0.2	0.2	0.4	0.6	0.5	-0.5	0.5	-0.5	-0.2
Bone: elastic work	0.3	0.3	0.7	-0.0	-0.6	0.6	-0.5	0.6	0.8
Bone: endosteal estimation	0.3	0.6	1.2	-0.2	-0.7	0.8	-0.8	0.8	1.1
Bone: endosteal perimeter	0.2	0.5	1.6	1.3	0.5	-0.4	0.5	-0.4	0.7
Epididymis fat weight	0.2	0.6	1.0	0.1	0.8	-0.7	0.8	-0.8	-1.0
Delta time in closed arm before/after self-admin	0.8	0.8	2.5	-1.6	-0.4	0.3	-0.4	0.4	-1.3
Delta time in open arm before/after self-admin	1.2	1.2	1.4	-0.9	-1.2	1.2	-1.1	1.0	1.1
Diff in mean of infusions in LGA sessions	1.6	1.8	2.3	1.2	1.4	-1.3	1.5	-1.5	-0.9
Delay discount exponential model param	2.0	2.1	2.6	1.2	1.6	-1.5	1.5	-1.6	-1.3
Extinction: sum of active levers before priming	1.7	1.7	3.4	0.6	1.3	-1.5	1.2	-1.2	-1.8
Active lever presses in extinction session 6	2.6	2.5	3.3	1.8	1.7	-1.7	1.6	-1.6	-0.9
Bone: final force	1.5	2.4	3.3	-0.7	-1.6	1.6	-1.6	1.6	1.8
Bone: final moment	1.2	1.9	2.8	-0.5	-1.4	1.4	-1.4	1.5	1.7
Food consumed during 24 hour testing period	0.5	0.5	0.9	-0.8	-0.7	0.7	-0.9	0.7	0.4
Glucose	1.1	1.7	2.1	-1.4	-1.4	1.3	-1.4	1.4	0.7
Heart weight	0.5	0.7	1.3	0.3	0.8	-0.8	0.9	-0.8	-1.1
Delay discount hyperbolic model param	2.9	3.1	3.7	1.4	1.9	-1.9	1.9	-1.9	-1.6
Intermittent access intake day 1-15 change	6.8	6.7	8.0	2.5	2.8	-2.8	2.6	-2.7	-2.1
Intermittent access intake escalation	7.3	7.2	8.6	2.0	2.8	-2.9	2.7	-2.7	-2.7
Intermittent access intake escalation 2	8.9	8.8	10.2	2.2	3.1	-3.2	3.1	-3.1	-3.0
Intermitt. access day 1 inactive lever presses	0.5	0.5	1.3	0.3	0.7	-0.9	0.5	-0.5	-1.1
Intermitt. access day 15 inactive lever presses	0.5	0.6	0.7	0.5	0.8	-0.8	0.8	-0.8	-0.8
Intermitt. access escalation Index	0.6	0.6	1.5	0.1	-0.6	0.7	-0.8	0.6	1.2
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.1	-0.2	0.3	-0.3	0.4	0.4
Intermittent access day 15 total infusions	2.1	2.3	2.8	1.2	1.7	-1.7	1.6	-1.5	-1.5
Intermittent access terminal intake (last 3 days)	1.1	1.2	1.5	1.0	1.2	-1.2	1.1	-1.0	-0.9
Intermittent access total infusions	0.2	0.2	0.3	0.4	0.6	-0.6	0.5	-0.4	-0.5
Intermittent access day 1 locomotion	0.3	0.3	0.5	0.5	0.7	-0.6	0.6	-0.6	-0.5
Intermittent access day 15 total locomotion	3.5	3.8	4.6	1.8	2.1	-2.2	2.0	-1.9	-1.6
Intermittent access total locomotion	0.9	1.0	1.4	1.2	1.1	-1.2	0.9	-0.8	-0.7
Intermittent access standard deviation	3.2	3.4	4.3	1.5	1.9	-2.1	1.8	-1.7	-1.8
Left kidney weight	0.0	0.1	0.5	0.7	0.1	-0.1	0.0	0.0	0.5
Right kidney weight	1.2	3.4	4.4	2.1	2.0	-1.9	2.0	-1.9	-1.0
Cocaine induced anxiety	0.4	0.5	1.4	1.2	0.6	-0.6	0.5	-0.4	0.3
Post-drug Anxiety	0.3	0.4	1.0	1.0	0.4	-0.3	0.6	-0.5	0.7
Baseline Anxiety	0.2	0.3	0.4	-0.1	0.4	-0.3	0.7	-0.6	-0.7
Tail length	3.1	9.5	11.0	2.8	3.2	-3.3	3.3	-3.2	-2.6
Length with tail	1.7	6.1	8.6	2.9	2.6	-2.6	2.6	-2.5	-1.3
Length without tail	0.1	0.3	1.0	0.9	0.0	-0.1	0.0	-0.0	1.0
Times rat made contact with spout	0.2	0.2	0.6	-0.8	-0.3	0.3	-0.3	0.3	-0.4
Lifetime Intake	0.1	0.1	0.1	0.3	0.3	-0.3	0.2	-0.1	-0.3
Liver weight, left	2.1	3.4	5.4	-2.3	-1.9	1.9	-1.8	1.8	0.7
Liver weight, right	1.7	2.8	3.3	-1.6	-1.8	1.8	-1.8	1.8	1.3
Locomotor activity	2.6	4.2	8.7	2.9	2.1	-2.0	2.0	-2.0	-0.3
Locomotor testing distance	1.6	2.7	4.8	2.2	1.7	-1.7	1.7	-1.7	-0.5
Locomotor testing rearing	0.1	0.1	0.2	-0.0	0.3	-0.3	0.4	-0.3	-0.5
Locomotion in novel chamber	0.5	0.6	1.6	0.3	0.7	-0.9	0.7	-0.6	-1.3
Locomotion in novel chamber post-restriction	0.7	0.9	1.1	0.9	1.1	-1.0	1.0	-0.9	-0.7
Fecal boli incidents, locomotor time 1	1.4	1.5	3.0	-1.7	-1.3	1.2	-1.2	1.2	0.1
Change in fecal boli incidents, locomotor task	0.3	0.3	1.0	1.0	0.3	-0.3	0.3	-0.3	0.7
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.3	-0.1	-0.8	0.7	-0.7	0.8	1.1
Bouts of movement, locomotor time 1	0.2	0.2	0.3	0.3	0.5	-0.5	0.5	-0.5	-0.5
Total resting periods, locomotor time 1	0.2	0.3	0.3	0.5	0.5	-0.5	0.5	-0.6	-0.3
Rest time, locomotor task time 1	0.1	0.1	0.3	0.5	0.4	-0.4	0.4	-0.3	-0.0
Distance moved, locomotor task time 1	0.7	0.8	2.0	-0.1	-0.9	0.8	-0.8	0.9	1.4
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.2	0.2	-0.0
Time >=10cm from walls, locomotor time 2	0.8	0.9	1.5	-1.2	-1.0	0.9	-0.9	1.0	0.2
Bouts of movement, locomotor time 2	0.3	0.3	1.0	1.0	0.4	-0.4	0.4	-0.4	0.5
Total resting periods, locomotor time 2	0.3	0.3	1.0	1.0	0.4	-0.3	0.3	-0.3	0.6
Rest time, locomotor task time 2	0.4	0.4	1.0	1.0	0.6	-0.6	0.6	-0.6	0.1
Distance moved, locomotor task time 2	0.5	0.6	1.3	-1.1	-0.8	0.8	-0.8	0.8	0.0
Vertical activity count, locomotor time 2	0.5	0.6	1.7	-1.3	-0.6	0.6	-0.6	0.7	-0.4
Light reinforcement 1	5.1	9.3	11.7	3.4	3.2	-3.2	3.2	-3.2	-1.8
Light reinforcement 2	1.6	2.2	3.0	1.7	1.6	-1.5	1.5	-1.6	-0.7
Bone: marrow area	0.3	0.6	1.2	-0.2	-0.8	0.8	-0.8	0.8	1.1
Bone: maximum diameter	0.6	1.0	3.4	1.8	0.8	-0.8	0.8	-0.8	0.6
Bone: maximum force	1.3	2.3	2.9	-0.8	-1.6	1.6	-1.5	1.6	1.7
Bone: maximum moment	1.1	1.9	2.5	-0.6	-1.4	1.5	-1.4	1.5	1.6
Mean time between licks in bursts	4.2	5.9	7.3	2.1	2.6	-2.6	2.7	-2.6	-2.1
Mean num. licks in bursts	0.1	0.1	0.3	0.0	-0.3	0.3	-0.3	0.3	0.5
Cd content in liver	0.2	0.2	0.3	-0.3	-0.5	0.5	-0.5	0.5	0.5
Co content in liver	0.6	0.7	0.9	0.6	0.9	-0.9	0.9	-0.9	-0.9
Cu content in liver	0.3	0.4	1.3	0.3	-0.5	0.5	-0.5	0.6	1.1
Fe content in liver	0.1	0.1	0.3	-0.2	0.3	-0.2	0.3	-0.3	-0.6
K content in liver	0.2	0.2	0.8	0.5	-0.3	0.2	-0.3	0.3	0.9
Mg content in liver	0.3	0.3	1.1	0.5	-0.3	0.2	-0.3	0.4	1.0
Mn content in liver	1.0	1.1	3.9	2.0	0.5	-0.5	0.5	-0.5	1.4
Na content in liver	1.3	1.4	2.1	-0.5	-1.2	1.2	-1.2	1.2	1.4
Rb content in liver	0.8	1.0	2.3	-0.0	-0.9	0.9	-1.0	0.9	1.5
Se content in liver	0.1	0.1	0.3	0.5	0.4	-0.4	0.3	-0.4	-0.1
Sr content in liver	0.2	0.2	0.9	-0.4	0.3	-0.3	0.2	-0.3	-0.9
Zn content in liver	2.9	3.2	6.4	0.6	1.8	-1.9	1.6	-1.8	-2.5
Bone: minimum diameter	0.1	0.2	0.9	0.5	-0.2	0.3	-0.3	0.3	1.0
Time in familiar zone, hab. session 1	2.3	2.2	3.0	1.1	1.6	-1.5	1.7	-1.7	-1.2
Time in novel zone, hab. session 1	1.5	1.4	2.4	-0.4	-1.2	1.1	-1.3	1.3	1.5
Total zone transitions, hab. session 1	0.6	0.8	2.5	1.6	0.8	-0.8	0.8	-0.7	0.5
Total locomotion distance, hab. session 1	0.8	1.2	3.8	2.0	0.7	-0.6	0.8	-0.7	1.2
Locomotion velocity, hab. session 1	1.0	1.4	4.0	2.0	1.0	-1.0	1.1	-1.0	0.6
Time in familiar zone, hab. session 2	6.7	6.9	8.2	2.0	2.8	-2.7	2.9	-2.8	-2.5
Time in novel zone, hab. session 2	5.2	5.2	6.2	-1.5	-2.4	2.4	-2.5	2.4	2.4
Total zone transitions, hab. session 2	0.7	0.9	3.0	0.3	-0.8	0.8	-0.7	0.8	1.7
Total locomotion distance, hab. session 2	0.6	0.7	1.9	1.4	0.7	-0.7	0.8	-0.8	0.4
Locomotion velocity, hab. session 2	0.5	0.7	2.2	1.5	0.6	-0.6	0.7	-0.7	0.7
Novel to familiar place preference ratio	4.8	5.0	6.1	-1.3	-2.3	2.3	-2.5	2.4	2.4
Novelty place preference	3.1	3.1	4.1	-0.9	-1.8	1.8	-2.0	1.9	2.0
Time in novel zone, NPP test	3.4	3.5	4.3	-1.1	-1.9	1.9	-2.1	2.0	2.0
Total zone transitions, NPP test	0.1	0.2	0.7	0.2	-0.3	0.3	-0.1	0.3	0.8
Total locomotion distance, NPP test	0.3	0.4	1.5	0.3	-0.5	0.5	-0.3	0.4	1.2
Locomotion velocity, NPP test	0.2	0.2	0.9	0.6	-0.2	0.2	-0.0	0.1	1.0
Intraocular pressure	0.5	0.7	2.7	-0.7	0.4	-0.5	0.5	-0.5	-1.6
Delta distance traveled before/after self-admin	1.5	1.6	2.3	1.3	1.4	-1.1	1.5	-1.5	-0.6
Delta ambulatory time before/after self-admin	1.5	1.6	2.1	1.5	1.4	-1.1	1.5	-1.4	-0.4
Parametrial fat weight	0.4	0.9	1.1	0.8	1.0	-1.0	1.0	-0.9	-0.8
Pavlov. Cond. lever latency	0.3	0.3	1.2	-0.4	0.3	-0.4	0.4	-0.3	-1.1
Pavlov. Cond. magazine entry latency	2.7	3.5	4.2	1.7	2.0	-2.0	2.0	-2.0	-1.5
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.3	0.2	-0.2	0.1	-0.2	-0.0
Pavlov. Cond. index score	0.3	0.3	0.9	0.9	0.5	-0.5	0.4	-0.6	0.2
Pavlov. Cond. latency score	0.3	0.3	1.1	1.1	0.4	-0.4	0.3	-0.5	0.6
Pavlov. Cond. lever contacts	0.3	0.3	1.3	0.7	-0.2	0.2	-0.3	0.2	1.1
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	-0.8	-0.9	0.9	-0.8	1.0	0.5
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.1	-0.1	0.5	-0.6	0.6	-0.5	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.4	1.2	0.8	-0.8	0.7	-0.9	0.0
Pavlov. Cond. response bias	0.9	1.1	1.4	1.1	1.1	-1.1	1.0	-1.2	-0.6
Pavlov. Cond. lever latency	0.8	1.0	1.5	-1.2	-1.1	1.0	-1.0	1.1	0.5
Pavlov. Cond. magazine entry latency	0.4	0.5	1.0	1.0	0.7	-0.7	0.7	-0.7	-0.2
Pavlov. Cond. change in total contacts	0.8	1.1	1.2	1.1	1.1	-1.1	1.1	-1.1	-0.8
Pavlov. Cond. index score	0.9	1.2	1.4	1.2	1.1	-1.1	1.2	-1.1	-0.6
Pavlov. Cond. latency score	0.8	1.0	1.6	1.2	1.0	-1.0	1.1	-1.0	-0.4
Pavlov. Cond. lever contacts	0.8	1.1	1.2	0.9	1.1	-1.1	1.1	-1.1	-0.9
Pavlov. Cond. magazine entry number	0.7	0.9	1.6	-1.3	-0.9	1.0	-1.0	0.9	0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.9	-0.9	-0.4	0.4	-0.4	0.4	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.6	1.3	1.1	-1.1	1.2	-1.1	-0.5
Pavlov. Cond. response bias	1.9	2.6	2.9	1.5	1.7	-1.7	1.7	-1.7	-1.3
Time in closed arm before self-admin	1.3	1.5	2.9	-0.4	-1.2	1.2	-1.2	1.2	1.7
Time in closed arm after self-admin	0.0	0.0	0.0	-0.1	0.1	0.0	0.1	-0.2	-0.2
Time in open arm before self-admin	0.9	1.0	1.5	0.9	1.1	-1.2	0.9	-0.8	-1.1
Time in open arm after self-admin	0.5	0.6	0.8	-0.8	-0.9	0.7	-0.9	0.9	0.4
Bone: periosteal estimation	0.6	1.3	3.2	0.1	-1.0	1.1	-1.1	1.1	1.8
Bone: periosteal perimeter	0.2	0.4	1.3	1.1	0.0	0.0	0.0	0.1	1.1
Bone: post-yield work	0.4	0.6	0.7	-0.8	-0.8	0.8	-0.8	0.8	0.5
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.5	-0.2	0.2	-0.2	0.3	-0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.6	-0.3	0.3	-0.3	0.4	-0.0
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.1	0.1	-0.1	-0.0	0.1	0.0
Progressive ratio test 2 active lever presses	0.3	0.3	0.8	0.2	0.6	-0.7	0.5	-0.4	-0.9
Progressive ratio test 2 breakpoint	0.3	0.3	0.5	0.5	0.6	-0.7	0.5	-0.4	-0.6
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	0.3	0.2	-0.2	0.1	0.0	-0.0
Incentive Sensitization - Responses	0.4	0.4	1.1	0.2	0.6	-0.8	0.4	-0.4	-1.0
Incentive Sensitization - Breakpoint	0.4	0.4	0.9	0.3	0.6	-0.8	0.5	-0.5	-1.0
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.1	0.0	-0.0	-0.0	0.1	-0.2
Progressive ratio	0.2	0.2	0.8	-0.9	-0.4	0.4	-0.3	0.3	-0.4
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.2	0.3	-0.3	0.3	-0.4	-0.2
Seeking ratio, punishment vs. effort	0.1	0.2	0.5	0.7	0.4	-0.3	0.3	-0.4	0.3
Retroperitoneal fat weight	0.3	0.8	1.4	-1.2	-0.9	1.0	-0.9	0.8	0.4
Reaction time number correct	0.4	0.6	2.1	-1.4	-0.5	0.5	-0.6	0.5	-0.6
Reaction time mean minus median	0.7	1.0	1.3	0.9	1.0	-1.1	1.1	-1.0	-0.7
Reaction time mean minus median AUC	0.2	0.2	1.0	0.7	-0.2	0.1	-0.1	0.2	1.0
Reaction time num false alarms	0.0	0.1	0.2	-0.4	-0.1	0.0	-0.2	0.1	-0.4
Reaction time num false alarms AUC	0.1	0.2	0.5	-0.7	-0.1	0.1	-0.2	0.1	-0.7
Reaction time trials correct on left	0.4	0.6	2.1	-1.4	-0.5	0.5	-0.6	0.5	-0.6
Reaction time trials on left	0.4	0.6	2.0	-1.4	-0.5	0.5	-0.7	0.6	-0.6
Reaction time mean	0.1	0.1	0.7	0.3	-0.2	0.2	0.0	0.1	0.8
Reaction time mean AUC	0.1	0.2	0.9	0.3	-0.3	0.3	-0.1	0.2	0.9
Median of all reaction times	0.4	0.6	1.5	-0.1	-0.7	0.8	-0.5	0.7	1.2
Reaction time omissions	0.2	0.2	0.5	0.7	0.5	-0.6	0.4	-0.4	-0.2
Reaction time false alarm rate	0.0	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1	0.1
Reaction time premature initiation rate	1.3	1.7	2.1	0.8	1.4	-1.3	1.4	-1.5	-1.4
Reaction time premature initiations	1.1	1.5	3.3	0.1	1.2	-1.2	1.2	-1.3	-1.8
Std. dev. reaction times	0.2	0.3	0.4	0.7	0.5	-0.6	0.6	-0.5	-0.1
Reaction time trials completed	0.4	0.6	2.0	-1.4	-0.5	0.5	-0.7	0.6	-0.6
Reaction time trials AUC	0.4	0.6	2.1	-1.5	-0.4	0.4	-0.6	0.4	-0.8
Run reversals in cocaine runway, females	0.3	0.3	0.7	0.8	0.5	-0.5	0.5	-0.5	-0.0
Run reversals in cocaine runway, males	1.0	1.0	1.5	1.2	1.1	-1.0	1.0	-1.1	-0.3
Latency to leave start box in cocaine runway	0.8	0.9	3.0	1.7	0.7	-0.9	0.7	-0.6	0.4
Latency to leave start box in cocaine runway, F	0.6	0.7	2.3	1.0	-0.4	0.2	-0.4	0.6	1.5
Latency to leave start box in cocaine runway, M	3.5	3.4	4.1	1.2	1.9	-1.9	1.9	-2.0	-2.0
Std. dev. time between licks in bursts	0.7	0.8	2.0	1.4	0.8	-0.8	1.0	-0.8	0.3
Total sessions with >9 infusions	0.1	0.1	0.2	0.3	-0.1	0.1	-0.3	0.4	0.5
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.1	0.2	-0.2	0.0	0.0	-0.2
Short access day 10 total inactive lever presses	0.1	0.1	0.5	-0.0	0.2	-0.4	0.1	-0.1	-0.7
Short access day 1 total infusions	0.1	0.1	0.4	0.6	0.2	-0.1	0.1	0.0	0.5
Short access day 10 total infusions	0.0	0.0	0.1	-0.0	0.2	-0.2	0.1	0.0	-0.3
Short access total infusions	0.0	0.0	0.1	0.1	-0.0	0.0	-0.1	0.2	0.2
Short access day 1 locomotion	0.7	0.8	1.9	1.4	0.9	-0.9	0.8	-0.6	0.0
Short access day 10 total locomotion	3.9	4.4	5.7	2.0	2.3	-2.4	2.0	-2.0	-1.9
Short access total locomotion	0.7	0.8	1.3	1.1	1.0	-1.0	0.8	-0.6	-0.5
One hour access (0.3 mA shock)	0.2	0.2	0.4	-0.4	-0.4	0.4	-0.5	0.6	0.3
Compulsive drug intake	1.3	1.3	1.7	-0.7	-1.2	1.2	-1.3	1.3	1.1
One hour access (shock baseline)	0.1	0.1	0.4	0.0	0.4	-0.4	0.3	-0.2	-0.6
Social response proportion	0.4	0.4	0.7	0.8	0.7	-0.6	0.7	-0.7	-0.0
Social responses	5.7	7.3	11.1	3.3	2.8	-2.8	2.9	-2.8	-1.1
Social time	0.5	0.7	1.1	-1.0	-0.9	0.9	-0.7	0.9	0.4
Soleus weight	8.2	24.1	27.4	-5.1	-5.2	5.2	-5.2	5.2	3.2
Bone: stiffness	3.0	4.7	5.5	-1.6	-2.3	2.3	-2.3	2.3	2.0
Tibialis anterior weight	1.0	3.6	4.9	-1.7	-2.0	1.9	-2.2	2.1	1.2
Time to tail flick, vehicle, before self-admin	0.3	0.4	1.2	1.1	0.4	-0.5	0.3	-0.5	0.4
Time to tail flick, vehicle, after self-admin	0.5	0.5	1.4	-0.4	0.5	-0.5	0.6	-0.8	-1.2
Time to tail flick, test, before self-admin	0.2	0.2	0.6	0.8	0.2	-0.2	0.2	-0.1	0.6
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.6	0.3	-0.3	0.3	-0.6	0.2
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.8	-1.3	-0.3	0.3	-0.1	0.2	-1.0
Delta time to tail flick, test, before/after SA	0.3	0.3	0.6	-0.0	0.5	-0.4	0.5	-0.6	-0.8
Tibia length	0.9	2.6	3.3	1.5	1.7	-1.7	1.8	-1.7	-1.2
Ambulatory time before self-admin	0.4	0.4	0.7	-0.3	-0.6	0.5	-0.8	0.8	0.5
Ambulatory time after self-admin	0.3	0.3	0.7	0.8	0.6	-0.6	0.5	-0.4	-0.2
Bone: tissue strength	1.6	1.6	1.9	-1.1	-1.4	1.4	-1.3	1.4	1.1
Total heroin consumption	1.8	2.1	2.5	1.5	1.5	-1.6	1.4	-1.5	-0.9
Bone: trabecular number	0.5	0.7	2.4	1.6	0.6	-0.6	0.5	-0.5	0.8
Bone: trabecular spacing	0.7	0.9	2.7	-1.6	-0.2	0.1	-0.0	0.1	-1.6
Bone: trabecular thickness	1.6	2.0	7.5	1.5	-0.7	0.7	-0.8	0.7	2.7
Bone: trabecular tissue density	1.3	1.9	3.8	-1.9	-1.4	1.4	-1.3	1.4	0.0
Water consumed over 24 hours	0.8	1.0	1.9	-0.3	-1.0	1.0	-1.1	1.0	1.4
Number of responses in last shaping day	0.1	0.1	0.3	0.5	0.4	-0.4	0.2	-0.1	-0.2