Hub : Genes

Acy3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Acy3	0.14	0.1	5.6e-04	0.02	0.01	0.02	0.02	1.0e-03	1.4e-02	3.3e-03	3.7e-03
2	Liver	gene expression	Acy3	0.69	0.12	0.0e+00	0.54	0.58	0.58	0.58	2.1e-71	4.6e-79	3.9e-80	8.9e-79
3	Liver	alternative TSS	XM_039108226.1	0.02	0.02	5.9e-03	0	0.01	0	0	1.3e-01	2.7e-02	2.7e-01	1.5e-01
4	Liver	alternative TSS	XM_039108222.1	0.02	0.02	6.7e-03	0	0.01	0	0	2.0e-01	3.1e-02	2.2e-01	1.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	2.4	4.0	5.3	-1.5	-1.8	-2.3	2.3
Area under the delay curve	1.1	1.2	1.5	-0.9	-1.0	-1.2	1.2
BMI with tail	0.7	2.3	4.2	-0.2	-0.9	-2.0	2.1
BMI without tail	0.4	0.8	1.4	-0.1	-0.5	-1.2	1.2
Body weight	0.5	2.0	5.3	2.3	1.6	0.2	-0.2
Weight adjusted by age	0.5	0.5	0.9	1.0	0.9	0.4	-0.4
Bone surface	1.2	2.1	3.7	-0.6	-0.9	-1.9	1.9
Bone volume	1.6	2.7	3.9	-1.1	-1.4	-2.0	2.0
Breakpoint value in progressive ratio session	0.4	0.4	1.2	1.1	0.8	0.1	-0.1
Number of licking bursts	0.1	0.1	0.1	-0.2	-0.2	-0.3	0.3
Context. condit. distance diff. score	0.7	0.8	1.4	-1.2	-0.9	-0.7	0.7
Locomotion velocity, session 1	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.1
Locomotion distance, session 1	1.1	1.4	2.0	-0.7	-0.9	-1.4	1.4
Locomotion velocity, session 2	0.7	0.8	1.7	1.3	1.1	0.5	-0.5
Locomotion distance, session 2	0.1	0.2	0.3	0.2	-0.1	-0.6	0.6
Locomotion velocity, session 3	1.6	1.9	2.4	-1.1	-1.3	-1.5	1.5
Locomotion distance, session 3	0.1	0.1	0.1	-0.3	-0.3	-0.4	0.4
Stereotopy head waving bouts, day 3	1.9	2.3	2.5	-1.4	-1.5	-1.6	1.6
Stereotopy head waving duration, day 3	1.5	1.8	2.1	-1.5	-1.4	-1.3	1.3
Locomotion velocity, session 7	1.3	1.4	1.7	-1.0	-1.1	-1.3	1.3
Locomotion distance, session 7	0.0	0.0	0.1	0.0	-0.1	-0.3	0.3
Stereotopy head waving bouts, day 7	2.0	2.2	2.4	-1.4	-1.6	-1.5	1.5
Stereotopy head waving duration, day 7	1.1	1.4	2.1	-0.6	-1.0	-1.4	1.4
Locomotion velocity, session 8	0.3	0.4	0.8	0.9	0.7	0.2	-0.2
Locomotion distance, session 8	0.5	0.7	0.8	-0.9	-0.8	-0.8	0.8
Degree of sensitization distance	0.1	0.1	0.2	-0.2	-0.3	-0.5	0.5
Degree of sensitization stereotypy	0.5	0.6	0.8	-0.4	-0.7	-0.9	0.9
Conditioned locomotion	4.2	4.9	5.8	2.4	2.4	2.0	-2.0
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.3
Cocaine response after cond. not corrected	0.6	0.6	0.7	-0.7	-0.8	-0.8	0.8
Cocaine response before conditioning	0.1	0.1	0.2	-0.2	-0.4	-0.4	0.4
Saline control response	0.5	0.7	1.6	1.3	1.0	0.3	-0.3
Bone: connectivity density	1.6	2.4	4.1	-0.7	-1.1	-2.0	2.0
Bone: cortical apparent density	0.5	0.6	1.0	1.0	0.8	0.6	-0.6
Bone: cortical area	0.9	1.3	1.5	1.2	1.2	1.1	-1.1
Bone: cortical porosity	0.1	0.1	0.1	-0.3	-0.2	-0.3	0.3
Bone: cortical porosity	0.0	0.0	0.1	0.3	0.3	0.1	-0.1
Bone: cortical thickness	5.3	8.7	11.0	3.3	3.2	2.6	-2.6
Bone: cortical thickness	1.9	2.2	3.1	1.7	1.6	1.2	-1.2
Bone: cortical tissue density	0.6	0.8	1.2	1.1	0.9	0.7	-0.7
Condit. Reinf. active minus inactive responses	0.4	0.4	0.5	-0.5	-0.5	-0.7	0.7
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.4	-0.6	-0.6	-0.7	0.7
Condit. Reinf. active responses	0.0	0.1	0.1	-0.2	-0.2	-0.3	0.3
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.1	0.1	0.2	-0.2
Incentive salience index mean	0.2	0.2	0.3	-0.3	-0.3	-0.6	0.6
Condit. Reinf. lever presses	0.1	0.1	0.1	0.2	0.3	0.3	-0.3
Condit. Reinf. active minus inactive responses	2.2	2.7	3.1	-1.6	-1.8	-1.6	1.6
Condit. Reinf. active-inactive response ratio	2.0	2.1	2.8	-1.7	-1.6	-1.2	1.2
Condit. Reinf. active responses	2.0	2.8	3.2	-1.4	-1.7	-1.8	1.8
Condit. Reinf. inactive responses	0.4	0.5	0.9	-0.2	-0.5	-1.0	1.0
Condit. Reinf. lever presses	0.3	0.5	0.8	-0.2	-0.4	-0.9	0.9
Condit. Reinf. lever reinforcers received	1.8	2.6	3.1	-1.3	-1.6	-1.8	1.8
Conditioned reinforcement - actives	0.2	0.2	0.4	0.2	0.2	0.6	-0.6
Conditioned reinforcement - inactives	1.4	1.6	3.1	-1.7	-1.6	-0.5	0.5
Conditioned locomotion	0.6	0.7	1.7	-1.3	-0.7	0.6	-0.6
Patch foraging indifference point 0 sec	0.2	0.3	0.6	-0.7	-0.8	-0.4	0.4
Patch foraging indifference point AUC	1.2	1.4	2.0	1.3	1.4	1.0	-1.0
Delay disc. indifference point, 0s delay	2.1	2.3	2.6	-1.3	-1.5	-1.6	1.6
Delay disc. indifference point, 16s delay	0.9	0.9	1.6	-1.3	-1.0	-0.7	0.7
Delay disc. indifference point, 2s delay	0.9	0.9	1.1	-1.0	-0.9	-1.0	1.0
Delay disc. indifference point, 24s delay	0.5	0.5	0.7	0.8	0.6	0.6	-0.6
Delay disc. indifference point, 4s delay	0.4	0.4	0.5	-0.5	-0.5	-0.7	0.7
Delay disc. indifference point, 8s delay	0.3	0.3	0.5	-0.3	-0.5	-0.7	0.7
Indifference point function ln k	0.8	1.2	2.5	-1.6	-1.3	-0.4	0.4
Indifference point function log k	0.8	1.2	2.5	-1.6	-1.3	-0.4	0.4
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.2
Patch foraging total patch changes 12 sec	0.6	0.8	1.6	1.3	1.1	0.5	-0.5
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	0.1	0.0	-0.2	0.1
Patch foraging total patch changes 24 sec	0.8	1.0	1.3	1.1	1.1	0.8	-0.8
Patch foraging total patch changes 6 sec	0.1	0.2	0.3	0.1	-0.3	-0.6	0.6
Patch foraging time to switch 0 sec	1.2	1.9	3.1	-0.6	-1.0	-1.8	1.8
Patch foraging water rate 0 sec	1.2	1.9	3.6	0.1	0.7	1.9	-1.9
Patch foraging water rate 12 sec	1.2	1.8	3.4	-0.2	0.6	1.9	-1.9
Patch foraging water rate 18 sec	0.1	0.2	0.2	-0.5	-0.0	0.5	-0.5
Patch foraging water rate 24 sec	1.1	1.5	2.6	0.4	0.8	1.6	-1.6
Patch foraging water rate 6 sec	1.1	1.6	2.6	0.5	1.0	1.6	-1.6
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.0	-0.7	-0.7	-1.0	1.0
Distance traveled before self-admin	0.0	0.0	0.1	-0.1	0.1	-0.3	0.3
Distance traveled after self-admin	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2
Extensor digitorum longus weight	2.5	10.0	18.5	4.3	3.7	2.0	-2.0
Bone: elastic displacement	2.8	3.1	4.1	1.3	1.6	2.0	-2.0
Bone: elastic work	2.8	3.6	4.1	2.0	2.0	1.7	-1.7
Bone: endosteal estimation	2.1	4.6	5.9	-2.4	-2.3	-1.9	1.9
Bone: endosteal perimeter	4.4	9.1	11.6	-3.4	-3.2	-2.7	2.7
Epididymis fat weight	0.9	2.1	4.3	-2.1	-1.7	-0.8	0.8
Delta time in closed arm before/after self-admin	1.2	1.2	1.9	1.4	1.1	0.9	-0.9
Delta time in open arm before/after self-admin	0.2	0.2	0.4	-0.6	-0.5	-0.4	0.4
Diff in mean of infusions in LGA sessions	0.4	0.4	0.7	0.7	0.8	0.5	-0.5
Delay discount exponential model param	0.7	0.8	1.0	0.7	0.8	1.0	-1.0
Extinction: sum of active levers before priming	0.3	0.3	0.7	0.8	0.5	-0.3	0.3
Active lever presses in extinction session 6	2.6	2.5	3.0	1.7	1.7	1.4	-1.4
Bone: final force	0.1	0.2	0.6	0.8	0.6	-0.1	0.1
Bone: final moment	0.1	0.2	0.5	0.7	0.6	-0.1	0.1
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.0	0.1	0.4	-0.4
Glucose	3.0	4.5	5.5	-2.3	-2.2	-2.0	2.0
Heart weight	0.9	1.2	2.1	-1.5	-1.3	-0.8	0.8
Delay discount hyperbolic model param	0.8	0.8	1.0	0.7	0.7	1.0	-1.0
Intermittent access intake day 1-15 change	0.1	0.1	0.3	-0.6	-0.1	0.3	-0.3
Intermittent access intake escalation	0.3	0.3	0.8	-0.9	-0.4	-0.1	0.1
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.5	-0.1	0.3	-0.3
Intermitt. access day 1 inactive lever presses	0.5	0.6	1.0	-0.9	-1.0	-0.5	0.5
Intermitt. access day 15 inactive lever presses	1.4	1.5	2.1	-1.5	-1.5	-0.9	0.9
Intermitt. access escalation Index	0.3	0.2	0.8	-0.9	-0.3	0.1	-0.1
Intermittent access day 1 total infusions	7.0	8.1	9.8	-2.9	-3.1	-2.7	2.7
Intermittent access day 15 total infusions	4.4	5.0	7.9	-2.8	-2.6	-1.6	1.6
Intermittent access terminal intake (last 3 days)	4.6	5.0	7.1	-2.7	-2.5	-1.8	1.8
Intermittent access total infusions	4.1	4.5	5.7	-2.4	-2.4	-1.9	1.9
Intermittent access day 1 locomotion	4.3	4.5	5.4	-2.0	-2.3	-2.1	2.1
Intermittent access day 15 total locomotion	2.5	2.6	4.5	-2.1	-1.8	-1.2	1.2
Intermittent access total locomotion	6.2	7.1	9.6	-3.1	-2.9	-2.3	2.3
Intermittent access standard deviation	0.1	0.2	0.4	-0.7	-0.4	-0.1	0.1
Left kidney weight	0.1	0.2	0.3	-0.4	-0.1	0.6	-0.6
Right kidney weight	0.3	0.8	1.4	0.2	0.4	1.2	-1.2
Cocaine induced anxiety	0.0	0.0	0.0	-0.0	-0.1	0.0	-0.0
Post-drug Anxiety	1.2	1.3	1.9	1.4	1.2	1.0	-1.0
Baseline Anxiety	1.5	1.6	2.2	1.5	1.5	1.0	-1.0
Tail length	1.4	4.2	5.3	2.3	2.1	1.9	-1.9
Length with tail	1.9	6.9	10.3	3.2	2.9	2.1	-2.1
Length without tail	1.1	2.4	4.2	2.0	1.8	1.1	-1.1
Times rat made contact with spout	0.2	0.3	0.5	-0.1	-0.3	-0.7	0.7
Lifetime Intake	3.6	4.0	5.3	-2.2	-2.3	-1.8	1.8
Liver weight, left	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.1
Liver weight, right	0.2	0.4	0.6	0.4	0.5	0.8	-0.8
Locomotor activity	0.1	0.1	0.3	-0.1	-0.0	0.5	-0.5
Locomotor testing distance	0.1	0.1	0.2	-0.2	-0.1	0.5	-0.5
Locomotor testing rearing	0.7	1.1	1.7	-1.3	-1.1	-0.9	0.9
Locomotion in novel chamber	2.7	3.3	6.0	-2.5	-2.0	-1.2	1.2
Locomotion in novel chamber post-restriction	0.7	0.8	1.8	-1.3	-1.1	-0.4	0.4
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.1
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.1	-0.1	-0.3	0.3
Time >=10cm from walls, locomotor time 1	4.9	5.0	5.7	-2.4	-2.4	-2.1	2.1
Bouts of movement, locomotor time 1	1.2	1.4	1.7	1.2	1.3	1.1	-1.1
Total resting periods, locomotor time 1	0.9	1.0	1.2	0.9	1.1	1.0	-1.0
Rest time, locomotor task time 1	0.3	0.3	0.6	-0.1	0.2	0.8	-0.8
Distance moved, locomotor task time 1	1.0	1.1	1.5	-0.7	-0.9	-1.2	1.2
Vertical activity count, locomotor time 1	1.2	1.3	1.7	-1.3	-1.3	-1.0	1.0
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.1	0.0	0.3	-0.3
Bouts of movement, locomotor time 2	0.3	0.4	0.8	0.9	0.6	0.4	-0.4
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.5	0.2	0.1	-0.1
Rest time, locomotor task time 2	2.0	2.3	3.1	-1.8	-1.7	-1.2	1.2
Distance moved, locomotor task time 2	1.1	1.2	1.6	1.2	1.3	1.0	-1.0
Vertical activity count, locomotor time 2	2.7	2.9	3.4	1.5	1.7	1.8	-1.8
Light reinforcement 1	0.0	0.1	0.1	-0.4	0.1	0.3	-0.3
Light reinforcement 2	0.2	0.2	0.7	-0.8	-0.4	0.2	-0.2
Bone: marrow area	2.1	4.6	5.9	-2.4	-2.3	-1.9	1.9
Bone: maximum diameter	0.0	0.0	0.1	-0.1	0.0	0.2	-0.2
Bone: maximum force	0.7	1.3	2.3	-0.4	-0.7	-1.5	1.5
Bone: maximum moment	0.6	1.0	1.8	-0.3	-0.6	-1.3	1.3
Mean time between licks in bursts	0.4	0.5	1.0	1.0	0.8	0.5	-0.5
Mean num. licks in bursts	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.3
Cd content in liver	0.2	0.2	0.5	-0.7	-0.4	0.1	-0.1
Co content in liver	0.8	0.9	1.3	0.6	0.8	1.1	-1.1
Cu content in liver	0.2	0.2	0.3	0.5	0.4	0.4	-0.4
Fe content in liver	0.0	0.0	0.0	0.1	0.2	0.1	-0.1
K content in liver	0.7	0.7	1.2	-0.2	-0.5	-1.1	1.1
Mg content in liver	3.5	3.6	4.3	-1.6	-1.8	-2.1	2.1
Mn content in liver	0.2	0.2	0.6	0.8	0.5	0.1	-0.1
Na content in liver	0.5	0.5	0.6	0.6	0.8	0.7	-0.7
Rb content in liver	3.8	4.7	5.5	-2.2	-2.3	-2.1	2.1
Se content in liver	1.0	1.3	1.4	-1.1	-1.1	-1.2	1.2
Sr content in liver	2.6	2.4	3.1	1.8	1.7	1.3	-1.3
Zn content in liver	0.3	0.4	0.7	0.8	0.7	0.4	-0.4
Bone: minimum diameter	2.8	5.2	5.7	-2.3	-2.4	-2.2	2.2
Time in familiar zone, hab. session 1	0.7	0.7	0.8	-0.9	-0.9	-0.7	0.7
Time in novel zone, hab. session 1	0.1	0.1	0.1	0.4	0.4	0.3	-0.3
Total zone transitions, hab. session 1	0.0	0.0	0.1	0.3	0.1	-0.2	0.2
Total locomotion distance, hab. session 1	0.4	0.5	0.8	-0.9	-0.8	-0.6	0.6
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.4	-0.3	-0.3	0.3
Time in familiar zone, hab. session 2	1.2	1.2	1.4	1.2	1.2	1.1	-1.1
Time in novel zone, hab. session 2	1.5	1.5	1.7	-1.1	-1.2	-1.3	1.3
Total zone transitions, hab. session 2	2.3	3.0	4.5	-1.0	-1.4	-2.1	2.1
Total locomotion distance, hab. session 2	1.5	2.0	2.4	-1.2	-1.3	-1.5	1.5
Locomotion velocity, hab. session 2	1.6	2.2	2.4	-1.4	-1.4	-1.6	1.6
Novel to familiar place preference ratio	0.4	0.4	0.5	-0.4	-0.6	-0.7	0.7
Novelty place preference	0.6	0.6	0.7	-0.6	-0.8	-0.9	0.9
Time in novel zone, NPP test	0.6	0.6	0.8	-0.6	-0.8	-0.9	0.9
Total zone transitions, NPP test	0.3	0.5	0.9	-0.2	-0.3	-0.9	0.9
Total locomotion distance, NPP test	0.4	0.6	0.7	-0.7	-0.7	-0.8	0.8
Locomotion velocity, NPP test	0.3	0.4	0.4	-0.6	-0.5	-0.6	0.6
Intraocular pressure	0.6	0.9	1.3	0.5	0.7	1.1	-1.1
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	0.3	0.2	0.3	-0.3
Parametrial fat weight	1.8	3.6	5.4	-2.3	-2.0	-1.6	1.6
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.1	-0.1	0.3	-0.3
Pavlov. Cond. magazine entry latency	1.5	1.9	2.1	-1.3	-1.3	-1.4	1.4
Pavlov. Cond. change in total contacts	1.0	1.0	1.4	-1.2	-1.0	-0.9	0.9
Pavlov. Cond. index score	0.1	0.1	0.2	-0.4	-0.2	-0.2	0.2
Pavlov. Cond. latency score	0.2	0.2	0.3	-0.5	-0.3	-0.5	0.5
Pavlov. Cond. lever contacts	0.1	0.1	0.1	-0.3	-0.1	-0.3	0.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.3	0.0	0.0	-0.0
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.7	0.4	0.6	0.9	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.1	-0.3	-0.2	-0.2	0.2
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.4	-0.2	-0.2	0.2
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.1	0.1	0.2	-0.2
Pavlov. Cond. magazine entry latency	0.4	0.4	0.8	0.3	-0.1	-0.9	0.9
Pavlov. Cond. change in total contacts	0.5	0.6	0.9	-0.5	-0.6	-1.0	1.0
Pavlov. Cond. index score	0.2	0.2	0.4	-0.0	-0.1	-0.7	0.7
Pavlov. Cond. latency score	0.1	0.2	0.3	-0.0	-0.1	-0.6	0.6
Pavlov. Cond. lever contacts	0.1	0.1	0.1	0.3	0.3	0.3	-0.3
Pavlov. Cond. magazine entry number	0.4	0.5	1.0	-0.4	0.1	1.0	-1.0
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.5	-0.7	-0.4	0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	0.1	-0.1	-0.6	0.6
Pavlov. Cond. response bias	0.0	0.1	0.1	0.2	0.0	-0.3	0.3
Time in closed arm before self-admin	0.4	0.4	0.7	-0.8	-0.6	-0.5	0.5
Time in closed arm after self-admin	0.2	0.2	0.3	0.6	0.4	0.5	-0.5
Time in open arm before self-admin	0.4	0.4	0.7	0.9	0.7	0.5	-0.5
Time in open arm after self-admin	0.1	0.1	0.1	0.3	0.2	0.3	-0.3
Bone: periosteal estimation	0.1	0.3	0.5	-0.7	-0.6	-0.4	0.4
Bone: periosteal perimeter	0.5	0.9	1.0	-1.0	-1.0	-0.9	0.9
Bone: post-yield work	9.6	13.1	14.7	-3.2	-3.6	-3.8	3.8
Progressive ratio test 1 active lever presses	0.3	0.3	0.8	-0.7	-0.9	-0.1	0.1
Progressive ratio test 1 breakpoint	0.2	0.2	0.5	-0.5	-0.7	0.0	-0.0
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.7	-0.5	-0.8	-0.4	0.4
Progressive ratio test 2 active lever presses	1.1	1.2	2.1	-1.4	-1.5	-0.6	0.6
Progressive ratio test 2 breakpoint	0.6	0.7	1.4	-1.2	-1.2	-0.2	0.2
Progressive ratio test 2 inactive lever presses	4.1	4.8	7.4	-2.7	-2.7	-1.5	1.5
Incentive Sensitization - Responses	0.2	0.2	0.4	-0.5	-0.7	-0.3	0.3
Incentive Sensitization - Breakpoint	0.3	0.3	0.5	-0.7	-0.7	-0.3	0.3
Sum of active levers in priming session hrs 5-6	3.8	3.7	4.2	1.8	1.8	2.0	-2.0
Progressive ratio	1.9	2.2	3.6	-0.7	-1.1	-1.9	1.9
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.4	0.2	-0.1	0.1
Seeking ratio, punishment vs. effort	1.2	1.5	2.3	0.6	1.0	1.5	-1.5
Retroperitoneal fat weight	1.5	4.8	10.0	-3.2	-2.5	-1.2	1.2
Reaction time number correct	1.0	1.5	1.6	1.3	1.3	1.1	-1.1
Reaction time mean minus median	0.1	0.2	0.3	0.6	-0.1	-0.4	0.4
Reaction time mean minus median AUC	0.3	0.4	1.1	1.1	0.6	0.3	-0.3
Reaction time num false alarms	0.9	1.3	1.5	1.1	1.0	1.2	-1.2
Reaction time num false alarms AUC	1.1	1.5	2.1	1.4	1.2	1.1	-1.1
Reaction time trials correct on left	1.0	1.5	1.6	1.3	1.3	1.1	-1.1
Reaction time trials on left	1.3	1.8	2.0	1.4	1.4	1.3	-1.3
Reaction time mean	0.4	0.6	0.8	-0.6	-0.9	-0.8	0.8
Reaction time mean AUC	0.6	0.8	1.1	-0.7	-1.0	-0.9	0.9
Median of all reaction times	0.8	1.1	1.4	-0.9	-1.2	-1.0	1.0
Reaction time omissions	0.5	0.7	1.5	1.2	0.8	0.6	-0.6
Reaction time false alarm rate	0.3	0.4	0.5	0.7	0.6	0.7	-0.7
Reaction time premature initiation rate	0.9	1.2	2.6	1.6	1.2	0.6	-0.6
Reaction time premature initiations	2.6	3.7	6.3	2.5	2.1	1.4	-1.4
Std. dev. reaction times	0.1	0.1	0.2	0.2	-0.4	-0.4	0.4
Reaction time trials completed	1.3	1.8	2.0	1.4	1.4	1.3	-1.3
Reaction time trials AUC	0.9	1.3	1.4	1.2	1.2	1.1	-1.1
Run reversals in cocaine runway, females	0.8	0.8	1.4	-0.3	-0.7	-1.2	1.2
Run reversals in cocaine runway, males	1.4	1.3	1.3	1.1	1.1	1.2	-1.2
Latency to leave start box in cocaine runway	1.5	1.6	1.8	-1.2	-1.2	-1.3	1.3
Latency to leave start box in cocaine runway, F	0.9	1.0	1.1	-1.0	-0.8	-1.1	1.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.2	-0.2	-0.2	0.2
Std. dev. time between licks in bursts	2.1	2.5	2.5	1.6	1.6	1.6	-1.6
Total sessions with >9 infusions	0.7	0.7	1.0	-0.9	-1.0	-0.7	0.7
Short access day 1 total inactive lever presses	1.1	1.2	2.1	-1.3	-1.4	-0.7	0.7
Short access day 10 total inactive lever presses	0.6	0.6	1.0	-1.0	-1.0	-0.6	0.6
Short access day 1 total infusions	2.7	2.9	3.8	-1.9	-2.0	-1.5	1.5
Short access day 10 total infusions	4.8	5.3	5.8	-2.1	-2.4	-2.4	2.4
Short access total infusions	2.1	2.4	3.1	-1.4	-1.8	-1.5	1.5
Short access day 1 locomotion	2.3	2.5	3.0	-1.7	-1.7	-1.4	1.4
Short access day 10 total locomotion	1.4	1.5	1.7	-1.3	-1.3	-1.2	1.2
Short access total locomotion	1.3	1.3	1.7	-1.0	-1.3	-1.1	1.1
One hour access (0.3 mA shock)	2.8	3.3	5.8	-2.4	-2.3	-1.1	1.1
Compulsive drug intake	3.3	3.4	5.7	2.4	1.9	1.5	-1.5
One hour access (shock baseline)	3.2	3.7	7.1	-2.7	-2.3	-1.1	1.1
Social response proportion	0.2	0.2	0.3	-0.0	-0.4	-0.6	0.6
Social responses	0.4	0.5	0.6	0.8	0.7	0.6	-0.6
Social time	0.1	0.1	0.3	0.6	0.5	0.1	-0.1
Soleus weight	0.3	0.9	2.3	-1.5	-0.7	0.6	-0.6
Bone: stiffness	1.2	1.8	2.9	-0.7	-1.0	-1.7	1.7
Tibialis anterior weight	7.0	23.9	34.8	5.9	5.4	3.9	-3.9
Time to tail flick, vehicle, before self-admin	1.7	1.8	2.6	-0.9	-1.0	-1.6	1.6
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.6	0.8	0.5	-0.1	0.1
Time to tail flick, test, before self-admin	2.4	2.3	2.6	-1.4	-1.5	-1.6	1.6
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.1	0.4	0.2	-0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.7	0.8	0.7	0.5	-0.5
Delta time to tail flick, test, before/after SA	5.0	4.5	5.0	2.1	2.2	2.1	-2.1
Tibia length	0.9	2.7	2.9	1.5	1.6	1.7	-1.7
Ambulatory time before self-admin	0.2	0.2	0.3	-0.4	-0.2	-0.5	0.5
Ambulatory time after self-admin	1.7	1.8	2.3	-1.5	-1.3	-1.3	1.3
Bone: tissue strength	0.3	0.3	0.4	-0.6	-0.5	-0.6	0.6
Total heroin consumption	1.2	1.4	2.9	1.7	1.3	0.6	-0.6
Bone: trabecular number	1.9	3.0	4.1	-1.3	-1.5	-2.0	2.0
Bone: trabecular spacing	0.6	0.8	1.0	0.6	0.8	1.0	-1.0
Bone: trabecular thickness	2.6	3.1	3.4	-1.7	-1.8	-1.7	1.7
Bone: trabecular tissue density	0.3	0.5	1.0	-1.0	-0.4	0.6	-0.6
Water consumed over 24 hours	0.1	0.1	0.2	0.2	0.1	-0.4	0.4
Number of responses in last shaping day	0.1	0.1	0.2	-0.2	-0.4	0.1	-0.1