Hub : Genes

Acy3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose isoform ratio XM_063286782.1 0.04 0.03 1.7e-03 0.02 0.01 0.01 0.01 3.2e-03 3.7e-02 5.8e-02 1.2e-02
2 Adipose gene expression Acy3 0.1 0.08 6.0e-04 0.02 0.02 0.03 0.02 1.3e-03 5.4e-03 4.1e-04 4.4e-03
3 Liver gene expression Acy3 0.76 0.12 0.0e+00 0.53 0.59 0.59 0.58 6.2e-70 1.3e-80 9.6e-82 8.3e-80

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.91.62.7-0.6-1.4-1.6
Area under the delay curve0.30.50.8-0.1-0.9-0.9
BMI with tail0.82.64.7-2.2-1.3-1.2
BMI without tail0.31.64.8-2.2-0.2-0.0
Body weight1.25.413.0-3.61.41.0
Weight adjusted by age0.41.11.5-1.21.00.9
Bone surface0.91.74.0-2.0-0.5-0.9
Bone volume0.51.11.6-0.9-0.9-1.3
Breakpoint value in progressive ratio session0.81.42.9-1.70.90.7
Number of licking bursts0.00.00.0-0.00.2-0.2
Context. condit. distance diff. score0.91.11.71.3-0.7-0.9
Locomotion velocity, session 10.00.00.00.00.1-0.1
Locomotion distance, session 10.40.50.8-0.7-0.6-0.9
Locomotion velocity, session 21.41.73.4-1.80.90.9
Locomotion distance, session 20.30.51.4-1.20.0-0.1
Locomotion velocity, session 30.81.01.6-0.1-1.2-1.3
Locomotion distance, session 30.10.10.10.1-0.3-0.4
Stereotopy head waving bouts, day 31.31.52.40.5-1.5-1.4
Stereotopy head waving duration, day 31.31.62.01.0-1.4-1.3
Locomotion velocity, session 70.60.71.00.0-1.0-1.0
Locomotion distance, session 70.10.10.3-0.6-0.1-0.1
Stereotopy head waving bouts, day 71.31.52.30.5-1.5-1.4
Stereotopy head waving duration, day 70.50.60.8-0.5-0.8-0.9
Locomotion velocity, session 80.91.11.7-1.31.00.7
Locomotion distance, session 80.30.50.70.6-0.6-0.8
Degree of sensitization distance0.10.10.3-0.5-0.3-0.2
Degree of sensitization stereotypy0.20.20.4-0.2-0.5-0.6
Conditioned locomotion3.84.45.8-1.72.42.2
Cocaine response after cond. corrected0.10.20.40.3-0.6-0.4
Cocaine response after cond. not corrected0.30.50.90.3-0.9-0.7
Cocaine response before conditioning0.00.00.0-0.1-0.1-0.2
Saline control response1.72.44.3-2.11.41.0
Bone: connectivity density1.01.53.2-1.8-0.7-1.0
Bone: cortical apparent density0.40.70.8-0.70.90.9
Bone: cortical area0.81.41.8-1.01.31.2
Bone: cortical porosity0.00.00.0-0.1-0.0-0.1
Bone: cortical porosity0.20.20.3-0.60.40.3
Bone: cortical thickness5.99.811.2-2.93.33.1
Bone: cortical thickness2.22.63.0-1.71.61.5
Bone: cortical tissue density0.60.91.1-0.91.01.0
Condit. Reinf. active minus inactive responses0.20.20.2-0.2-0.5-0.5
Condit. Reinf. active-inactive response ratio0.20.20.30.2-0.6-0.6
Condit. Reinf. active responses0.00.10.10.0-0.3-0.2
Condit. Reinf. inactive responses0.00.00.10.3-0.10.0
Incentive salience index mean0.10.10.1-0.3-0.3-0.3
Condit. Reinf. lever presses0.10.10.1-0.20.40.2
Condit. Reinf. active minus inactive responses1.31.92.90.8-1.7-1.5
Condit. Reinf. active-inactive response ratio1.62.63.11.5-1.8-1.5
Condit. Reinf. active responses1.01.52.40.1-1.6-1.4
Condit. Reinf. inactive responses0.30.41.2-1.1-0.2-0.3
Condit. Reinf. lever presses0.30.40.6-0.8-0.5-0.6
Condit. Reinf. lever reinforcers received0.91.32.1-0.1-1.4-1.3
Conditioned reinforcement - actives0.10.30.40.60.40.5
Conditioned reinforcement - inactives1.23.44.32.1-1.9-1.4
Conditioned locomotion4.05.912.83.6-1.8-1.3
Patch foraging indifference point 0 sec0.20.50.60.8-0.7-0.6
Patch foraging indifference point AUC0.71.72.0-1.21.41.3
Delay disc. indifference point, 0s delay1.11.32.10.0-1.3-1.4
Delay disc. indifference point, 16s delay0.70.91.21.1-1.0-0.8
Delay disc. indifference point, 2s delay0.80.91.10.7-1.1-1.0
Delay disc. indifference point, 24s delay0.20.30.5-0.40.70.6
Delay disc. indifference point, 4s delay0.20.20.3-0.2-0.6-0.5
Delay disc. indifference point, 8s delay0.10.20.2-0.4-0.4-0.5
Indifference point function ln k1.33.87.22.7-1.7-1.2
Indifference point function log k1.33.87.22.7-1.7-1.2
Patch foraging total patch changes 0 sec0.00.10.20.5-0.10.0
Patch foraging total patch changes 12 sec1.62.23.8-1.91.31.1
Patch foraging total patch changes 18 sec0.10.20.3-0.60.30.1
Patch foraging total patch changes 24 sec0.41.21.4-1.11.21.0
Patch foraging total patch changes 6 sec0.30.41.3-1.10.1-0.1
Patch foraging time to switch 0 sec0.20.91.7-1.3-0.3-1.0
Patch foraging water rate 0 sec0.62.26.12.50.00.7
Patch foraging water rate 12 sec0.83.410.03.2-0.20.4
Patch foraging water rate 18 sec0.40.82.31.5-0.4-0.1
Patch foraging water rate 24 sec0.81.12.71.60.30.8
Patch foraging water rate 6 sec0.81.22.21.50.70.9
Seeking ratio, delayed vs. immediate footshock0.50.71.3-0.2-1.1-0.8
Distance traveled before self-admin0.00.10.2-0.1-0.3-0.5
Distance traveled after self-admin0.00.00.0-0.10.2-0.1
Extensor digitorum longus weight5.321.032.5-5.74.13.7
Bone: elastic displacement1.31.72.80.01.51.7
Bone: elastic work2.83.64.5-1.72.11.9
Bone: endosteal estimation1.74.14.61.8-2.1-2.1
Bone: endosteal perimeter3.68.910.02.7-3.2-3.1
Epididymis fat weight1.68.315.64.0-2.4-1.8
Delta time in closed arm before/after self-admin1.51.41.6-1.21.31.1
Delta time in open arm before/after self-admin0.30.30.60.0-0.8-0.6
Diff in mean of infusions in LGA sessions0.50.91.2-0.91.10.8
Delay discount exponential model param0.20.30.50.20.70.7
Extinction: sum of active levers before priming0.60.92.3-1.50.40.1
Active lever presses in extinction session 61.11.11.4-1.20.81.1
Bone: final force0.61.02.3-1.50.70.4
Bone: final moment0.61.02.2-1.50.80.5
Food consumed during 24 hour testing period0.10.20.40.60.30.2
Glucose3.55.56.81.8-2.6-2.6
Heart weight1.32.13.00.6-1.7-1.7
Delay discount hyperbolic model param0.30.40.70.10.80.8
Intermittent access intake day 1-15 change0.42.25.62.4-0.7-0.8
Intermittent access intake escalation0.31.84.92.2-0.5-0.6
Intermittent access intake escalation 20.91.63.71.9-0.6-0.8
Intermitt. access day 1 inactive lever presses0.00.10.20.0-0.4-0.1
Intermitt. access day 15 inactive lever presses0.52.63.91.2-2.0-1.5
Intermitt. access escalation Index0.41.33.71.9-0.3-0.1
Intermittent access day 1 total infusions2.16.211.01.1-3.3-2.5
Intermittent access day 15 total infusions2.86.87.92.8-2.8-2.2
Intermittent access terminal intake (last 3 days)4.17.19.62.4-3.1-2.4
Intermittent access total infusions4.25.07.51.7-2.7-2.1
Intermittent access day 1 locomotion1.73.25.81.0-2.4-1.7
Intermittent access day 15 total locomotion1.76.47.92.8-2.6-2.1
Intermittent access total locomotion7.99.511.43.1-3.4-2.7
Intermittent access standard deviation0.21.01.41.2-0.8-0.9
Left kidney weight0.42.95.22.3-1.3-1.3
Right kidney weight0.21.33.41.8-0.5-0.5
Cocaine induced anxiety0.00.10.10.2-0.4-0.4
Post-drug Anxiety0.10.20.5-0.70.10.1
Baseline Anxiety0.30.50.7-0.80.60.6
Tail length0.84.35.4-1.82.32.1
Length with tail2.29.912.0-3.23.52.8
Length without tail1.26.47.5-2.72.72.1
Times rat made contact with spout0.20.20.5-0.7-0.0-0.3
Lifetime Intake2.63.35.31.3-2.3-1.7
Liver weight, left0.20.30.60.80.40.4
Liver weight, right0.40.72.11.5-0.1-0.1
Locomotor activity0.30.51.41.20.00.0
Locomotor testing distance0.20.51.51.2-0.10.1
Locomotor testing rearing0.31.31.51.2-1.1-1.0
Locomotion in novel chamber4.76.48.32.9-2.6-2.0
Locomotion in novel chamber post-restriction1.23.75.92.4-1.8-1.4
Fecal boli incidents, locomotor time 10.00.10.10.3-0.4-0.1
Change in fecal boli incidents, locomotor task0.00.00.1-0.30.2-0.1
Time >=10cm from walls, locomotor time 13.23.95.71.3-2.4-2.1
Bouts of movement, locomotor time 11.72.24.1-0.92.01.3
Total resting periods, locomotor time 11.21.42.7-0.51.61.1
Rest time, locomotor task time 10.40.72.11.40.1-0.1
Distance moved, locomotor task time 10.30.71.4-0.3-1.2-0.9
Vertical activity count, locomotor time 10.21.52.40.9-1.5-1.2
Time >=10cm from walls, locomotor time 20.00.10.10.4-0.00.1
Bouts of movement, locomotor time 20.10.40.6-0.80.60.6
Total resting periods, locomotor time 20.00.10.2-0.40.30.2
Rest time, locomotor task time 21.42.42.41.5-1.5-1.6
Distance moved, locomotor task time 21.11.41.6-1.11.31.3
Vertical activity count, locomotor time 20.71.62.5-0.31.51.6
Light reinforcement 10.10.41.01.0-0.2-0.1
Light reinforcement 20.61.43.71.9-0.6-0.4
Bone: marrow area1.74.34.81.8-2.2-2.2
Bone: maximum diameter0.00.10.20.50.1-0.0
Bone: maximum force0.50.92.2-1.5-0.3-0.6
Bone: maximum moment0.40.82.2-1.5-0.2-0.5
Mean time between licks in bursts0.10.50.8-0.90.60.6
Mean num. licks in bursts0.00.10.2-0.1-0.5-0.3
Cd content in liver1.41.52.51.6-1.1-0.9
Co content in liver0.60.81.20.50.91.1
Cu content in liver0.00.00.00.0-0.20.0
Fe content in liver0.20.20.4-0.60.30.3
K content in liver0.20.20.5-0.7-0.1-0.2
Mg content in liver0.60.60.70.6-0.9-0.8
Mn content in liver1.31.42.9-1.70.90.8
Na content in liver0.40.50.8-0.00.90.8
Rb content in liver1.72.02.31.2-1.5-1.5
Se content in liver0.50.60.90.4-1.0-0.9
Sr content in liver2.52.22.3-1.41.51.5
Zn content in liver0.50.60.7-0.70.80.9
Bone: minimum diameter1.83.54.71.3-2.0-2.2
Time in familiar zone, hab. session 10.60.70.80.9-0.8-0.9
Time in novel zone, hab. session 10.10.10.1-0.40.30.4
Total zone transitions, hab. session 10.20.30.7-0.80.40.2
Total locomotion distance, hab. session 10.40.50.60.7-0.8-0.7
Locomotion velocity, hab. session 10.10.10.10.3-0.3-0.3
Time in familiar zone, hab. session 20.91.11.9-0.51.41.0
Time in novel zone, hab. session 20.80.91.60.1-1.3-1.1
Total zone transitions, hab. session 21.21.51.8-1.1-1.2-1.3
Total locomotion distance, hab. session 20.81.01.6-0.0-1.3-1.2
Locomotion velocity, hab. session 21.01.32.00.3-1.4-1.4
Novel to familiar place preference ratio0.10.20.2-0.4-0.5-0.5
Novelty place preference0.20.30.4-0.1-0.7-0.7
Time in novel zone, NPP test0.20.30.4-0.1-0.7-0.7
Total zone transitions, NPP test0.30.41.1-1.10.0-0.4
Total locomotion distance, NPP test0.20.30.50.1-0.6-0.7
Locomotion velocity, NPP test0.10.20.30.1-0.4-0.5
Intraocular pressure0.20.40.40.60.50.6
Delta distance traveled before/after self-admin0.10.20.3-0.10.60.4
Delta ambulatory time before/after self-admin0.10.20.3-0.30.60.5
Parametrial fat weight2.66.18.83.0-2.2-2.2
Pavlov. Cond. lever latency0.10.20.30.5-0.5-0.1
Pavlov. Cond. magazine entry latency0.50.71.20.4-0.8-1.1
Pavlov. Cond. change in total contacts0.70.70.90.8-0.8-0.9
Pavlov. Cond. index score0.10.10.10.40.1-0.2
Pavlov. Cond. latency score0.00.10.10.20.0-0.4
Pavlov. Cond. lever contacts0.00.00.1-0.10.3-0.1
Pavlov. Cond. magazine entry number0.10.10.2-0.5-0.10.2
Pavlov. Cond. intertrial magazine entries0.20.20.40.30.40.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.10.30.1-0.3
Pavlov. Cond. response bias0.10.10.10.40.3-0.1
Pavlov. Cond. lever latency0.00.10.10.0-0.4-0.1
Pavlov. Cond. magazine entry latency0.91.23.7-1.90.2-0.1
Pavlov. Cond. change in total contacts0.10.30.4-0.3-0.6-0.7
Pavlov. Cond. index score0.20.30.8-0.9-0.0-0.2
Pavlov. Cond. latency score0.10.20.5-0.70.0-0.2
Pavlov. Cond. lever contacts0.00.00.1-0.10.30.1
Pavlov. Cond. magazine entry number1.21.64.72.2-0.30.0
Pavlov. Cond. intertrial magazine entries0.30.71.81.4-0.4-0.3
Pavlov. Cond. lever-magazine prob. diff.0.30.41.2-1.10.1-0.2
Pavlov. Cond. response bias0.20.30.9-0.90.1-0.2
Time in closed arm before self-admin1.11.93.11.0-1.8-1.2
Time in closed arm after self-admin0.00.00.00.2-0.10.1
Time in open arm before self-admin1.61.93.3-0.91.81.2
Time in open arm after self-admin0.30.40.8-0.90.50.3
Bone: periosteal estimation0.10.20.30.5-0.4-0.5
Bone: periosteal perimeter0.40.71.10.5-0.9-1.0
Bone: post-yield work4.47.611.70.6-3.3-3.4
Progressive ratio test 1 active lever presses0.00.10.20.0-0.4-0.0
Progressive ratio test 1 breakpoint0.00.00.1-0.0-0.40.0
Progressive ratio test 1 inactive lever presses0.10.20.4-0.0-0.7-0.1
Progressive ratio test 2 active lever presses1.52.22.71.5-1.7-1.2
Progressive ratio test 2 breakpoint1.51.92.41.4-1.6-1.1
Progressive ratio test 2 inactive lever presses2.68.29.83.1-3.1-2.3
Incentive Sensitization - Responses0.20.60.90.2-1.0-0.9
Incentive Sensitization - Breakpoint0.30.81.10.4-1.1-1.0
Sum of active levers in priming session hrs 5-62.22.13.30.01.81.7
Progressive ratio0.61.72.4-1.0-1.4-1.5
Food seeking constrained by brief footshock0.10.10.2-0.4-0.4-0.1
Seeking ratio, punishment vs. effort0.30.81.10.90.61.0
Retroperitoneal fat weight4.922.140.46.4-3.8-3.4
Reaction time number correct0.31.11.8-0.51.41.1
Reaction time mean minus median0.21.13.0-1.70.50.1
Reaction time mean minus median AUC0.21.42.7-1.61.00.7
Reaction time num false alarms0.50.91.5-0.21.21.0
Reaction time num false alarms AUC0.61.52.2-0.91.51.2
Reaction time trials correct on left0.31.11.8-0.51.41.1
Reaction time trials on left0.41.42.2-0.61.51.2
Reaction time mean0.10.30.60.0-0.5-0.8
Reaction time mean AUC0.20.40.80.1-0.6-0.9
Median of all reaction times0.50.71.20.5-0.9-1.1
Reaction time omissions1.21.93.6-1.91.20.8
Reaction time false alarm rate0.20.30.5-0.40.70.6
Reaction time premature initiation rate1.72.65.2-2.31.11.1
Reaction time premature initiations1.64.97.0-2.62.11.9
Std. dev. reaction times0.10.30.9-0.90.1-0.2
Reaction time trials completed0.41.42.2-0.61.51.2
Reaction time trials AUC0.31.01.8-0.51.31.0
Run reversals in cocaine runway, females0.30.40.8-0.9-0.2-0.5
Run reversals in cocaine runway, males0.60.71.1-0.31.00.9
Latency to leave start box in cocaine runway0.81.11.60.4-1.3-1.2
Latency to leave start box in cocaine runway, F0.60.81.30.3-1.1-1.0
Latency to leave start box in cocaine runway, M0.00.00.0-0.1-0.1-0.2
Std. dev. time between licks in bursts1.12.13.2-0.91.81.6
Total sessions with >9 infusions0.20.30.6-0.3-0.8-0.4
Short access day 1 total inactive lever presses0.81.72.21.5-1.4-0.9
Short access day 10 total inactive lever presses0.00.10.1-0.1-0.4-0.1
Short access day 1 total infusions0.91.73.01.0-1.7-1.1
Short access day 10 total infusions1.62.75.6-0.0-2.4-1.6
Short access total infusions0.81.12.30.0-1.5-1.0
Short access day 1 locomotion0.91.52.61.0-1.6-1.0
Short access day 10 total locomotion0.51.93.20.9-1.8-1.3
Short access total locomotion1.32.03.31.0-1.8-1.2
One hour access (0.3 mA shock)4.14.85.72.4-2.3-1.8
Compulsive drug intake2.53.74.0-1.92.01.9
One hour access (shock baseline)2.87.39.53.1-2.8-2.2
Social response proportion0.10.10.3-0.60.1-0.3
Social responses0.50.61.0-0.71.00.7
Social time0.30.50.8-0.90.70.4
Soleus weight1.74.913.23.6-1.0-0.7
Bone: stiffness0.40.81.1-1.0-0.6-0.9
Tibialis anterior weight8.629.833.1-5.85.55.1
Time to tail flick, vehicle, before self-admin0.40.50.7-0.4-0.8-0.8
Time to tail flick, vehicle, after self-admin0.40.82.1-1.4-0.5-0.5
Time to tail flick, test, before self-admin2.02.33.20.8-1.8-1.8
Time to tail flick, test, after self-admin0.10.10.30.10.50.3
Delta time to tail flick, vehicle, before/after SA0.30.30.9-1.00.10.1
Delta time to tail flick, test, before/after SA3.64.46.7-0.92.62.4
Tibia length0.61.72.4-0.61.51.6
Ambulatory time before self-admin0.10.20.5-0.0-0.4-0.7
Ambulatory time after self-admin0.71.21.60.9-1.1-1.2
Bone: tissue strength0.30.30.40.4-0.5-0.6
Total heroin consumption2.73.15.2-2.31.71.2
Bone: trabecular number0.71.42.2-0.7-1.2-1.5
Bone: trabecular spacing0.20.30.30.50.40.6
Bone: trabecular thickness1.11.52.40.5-1.4-1.5
Bone: trabecular tissue density2.03.59.93.1-0.5-0.4
Water consumed over 24 hours0.20.41.2-1.10.20.0
Number of responses in last shaping day0.10.10.1-0.30.20.3