Hub : Genes

Acvr1c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Acvr1c 0.35 0.08 0.0e+00 0.55 0.54 0.56 0.56 8.9e-61 4.1e-59 1.3e-61 2.9e-62
2 Brain intron excision ratio chr3_42841102_42861024 0.05 0.04 1.9e-04 0.01 0.03 0.03 0.02 4.0e-02 5.0e-04 1.7e-03 6.6e-03
3 Brain intron excision ratio chr3_42841021_42861024 0.04 0.03 2.0e-04 0.01 0.03 0.01 0.01 2.2e-02 1.5e-03 1.7e-02 1.4e-02
4 NAcc gene expression Acvr1c 0.03 0.02 2.2e-04 0.04 0.03 0.04 0.04 4.8e-05 5.8e-04 5.5e-05 2.0e-05
5 OFC gene expression Acvr1c 0.21 0.17 7.3e-03 0.11 0.06 0.1 0.11 1.4e-03 1.6e-02 2.2e-03 1.8e-03
6 RMTg gene expression Acvr1c 0.13 0.08 1.2e-03 0.04 0.06 0.04 0.04 3.7e-02 1.3e-02 2.9e-02 3.2e-02
7 Adipose intron excision ratio chr3_42841102_42861024 0.05 0.03 1.2e-07 0.07 0.06 0.06 0.06 8.5e-08 6.6e-07 6.4e-07 2.4e-07
8 Adipose mRNA stability Acvr1c 0.02 0.01 8.0e-03 0.01 0 -0 0 1.3e-02 3.5e-01 5.1e-01 1.5e-01
9 Brain alternative TSS NM_139090.2 0.02 0.02 7.6e-03 0.02 0.02 0.01 0.01 7.3e-03 8.7e-03 1.9e-02 3.3e-02
10 Brain intron excision ratio chr3_42827274_42828084 0.21 0.09 0.0e+00 0.34 0.33 0.32 0.32 2.2e-32 4.2e-31 1.6e-30 1.6e-30
11 Adipose isoform ratio XM_039104246.1 0.04 0.03 2.3e-05 0.03 0.03 0.01 0.02 3.0e-04 3.3e-04 8.0e-03 2.0e-03
12 Brain alternative TSS XM_039104246.1 0.03 0.02 7.1e-03 0.02 0.02 0.01 0.01 8.5e-03 9.2e-03 2.3e-02 4.4e-02
13 Brain intron excision ratio chr3_42827274_42828613 0.2 0.08 0.0e+00 0.31 0.32 0.32 0.31 3.7e-29 2.3e-30 6.6e-30 4.7e-29
14 Brain isoform ratio XM_039104246.1 0.08 0.05 2.5e-07 0.09 0.07 0.08 0.09 2.8e-08 1.8e-07 1.5e-07 1.8e-08
15 Brain isoform ratio NM_139090.2 0.08 0.05 2.8e-07 0.08 0.07 0.07 0.09 3.4e-08 1.9e-07 1.7e-07 2.2e-08
16 Adipose intron excision ratio chr3_42834924_42840863 0.02 0.01 7.7e-03 0.02 0.01 0.01 0.01 4.9e-03 1.5e-02 2.3e-02 9.1e-03
17 Brain mRNA stability Acvr1c 0.06 0.04 4.7e-06 0.04 0.06 0.05 0.05 5.9e-05 6.4e-06 4.2e-05 4.3e-05
18 Adipose isoform ratio NM_139090.2 0.04 0.03 2.2e-05 0.03 0.03 0.02 0.02 2.1e-04 1.6e-04 1.2e-03 1.1e-03
19 Adipose gene expression Acvr1c 0.12 0.06 0.0e+00 0.15 0.16 0.16 0.15 1.3e-16 1.6e-17 3.7e-17 1.3e-16
20 Adipose alternative polyA NM_139090.2 0.02 0.01 6.9e-03 0.01 0.01 0 0.01 2.9e-02 9.7e-03 1.1e-01 4.8e-02
21 PL intron excision ratio chr3_42841102_42861024 0.02 0.02 6.5e-03 0 0 -0 -0 3.4e-01 7.5e-02 8.7e-01 9.7e-01
22 Adipose alternative polyA XM_039104246.1 0.02 0.02 4.3e-03 0.01 0.02 0.01 0.01 2.1e-02 5.9e-03 5.0e-02 2.6e-02
23 PL intron excision ratio chr3_42841021_42861024 0.02 0.02 6.1e-03 -0 0 -0 -0 3.9e-01 9.0e-02 8.7e-01 9.8e-01
24 Liver gene expression Acvr1c 0.09 0.05 6.3e-07 0.05 0.04 0.04 0.04 4.0e-06 2.3e-05 1.0e-05 1.2e-05
25 IL gene expression Acvr1c 0.31 0.16 7.6e-03 0.03 0.09 -0 0.01 8.1e-02 4.5e-03 4.2e-01 1.5e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
Bone: apparent density0.61.15.5-0.9-1.71.3-0.91.2-0.90.81.20.70.7-0.7-1.01.0-1.01.0-1.00.9-0.6-0.7-0.7-0.70.70.7-2.30.1
Area under the delay curve0.10.10.8-0.3-0.00.3-0.40.1-0.20.2-0.40.20.2-0.2-0.30.4-0.50.5-0.50.2-0.4-0.3-0.5-0.40.50.4-0.00.9
BMI with tail0.00.10.20.0-0.00.1-0.4-0.1-0.1-0.0-0.0-0.1-0.10.0-0.40.1-0.40.4-0.40.0-0.2-0.1-0.2-0.10.20.1-0.50.5
BMI without tail1.83.85.4-2.0-1.41.7-2.32.0-1.91.62.01.51.5-1.6-2.22.0-2.22.2-2.22.0-2.0-2.1-2.1-2.02.12.0-1.71.8
Body weight1.04.36.1-2.3-1.31.8-1.91.6-2.12.01.81.91.9-1.9-2.12.2-2.12.1-2.12.2-2.4-2.3-2.4-2.32.42.3-1.62.5
Weight adjusted by age0.40.41.0-0.7-0.50.6-0.90.5-0.60.30.60.10.1-0.2-0.90.7-1.01.0-1.00.6-0.7-0.6-0.7-0.60.70.6-0.50.6
Bone surface0.30.51.8-0.7-1.41.0-0.60.6-0.70.70.60.70.7-0.7-0.80.7-0.80.8-0.80.6-0.4-0.4-0.4-0.40.40.3-1.1-0.2
Bone volume0.30.62.9-0.6-1.41.1-0.70.8-0.60.60.70.60.6-0.7-0.80.7-0.80.8-0.80.6-0.4-0.4-0.4-0.40.40.4-1.7-0.0
Breakpoint value in progressive ratio session0.30.40.90.40.2-0.40.9-0.80.5-0.1-0.6-0.1-0.1-0.11.0-0.41.0-1.01.0-0.50.60.50.60.6-0.6-0.50.4-0.6
Number of licking bursts2.93.44.42.01.5-1.92.0-1.62.0-1.9-1.5-2.0-2.02.12.0-2.02.0-2.02.0-2.01.91.91.91.9-1.9-1.80.5-1.4
Context. condit. distance diff. score0.20.20.90.20.5-0.30.8-0.70.4-0.0-1.0-0.0-0.00.00.6-0.20.6-0.60.6-0.40.20.30.10.3-0.1-0.20.70.4
Locomotion velocity, session 10.30.30.9-0.6-0.30.4-0.71.0-0.50.20.80.20.2-0.2-0.70.5-0.70.7-0.70.5-0.6-0.6-0.6-0.60.60.6-0.90.7
Locomotion distance, session 10.71.02.6-1.0-1.21.1-1.21.6-1.10.71.50.70.7-0.7-1.10.9-1.11.1-1.10.9-0.8-0.8-0.8-0.80.80.8-0.50.2
Locomotion velocity, session 20.60.71.31.20.3-0.70.20.10.9-1.1-0.0-1.1-1.11.10.3-0.90.3-0.30.3-0.91.00.91.00.9-1.0-0.9-0.9-0.9
Locomotion distance, session 22.43.37.5-1.8-2.12.0-2.32.7-1.81.32.61.31.3-1.3-2.11.7-2.12.1-2.11.7-1.5-1.6-1.5-1.51.51.5-1.80.6
Locomotion velocity, session 30.00.00.70.0-0.20.10.00.00.10.10.20.10.1-0.1-0.1-0.0-0.10.1-0.1-0.10.00.0-0.00.00.0-0.0-0.90.3
Locomotion distance, session 31.82.02.9-1.7-1.11.5-1.30.8-1.41.60.61.61.6-1.6-1.41.6-1.41.4-1.41.4-1.5-1.4-1.6-1.51.61.5-0.31.6
Stereotopy head waving bouts, day 30.30.42.5-0.4-1.61.0-0.20.7-0.60.60.80.60.6-0.6-0.20.3-0.20.2-0.20.30.10.10.10.1-0.2-0.2-0.2-1.4
Stereotopy head waving duration, day 30.40.52.8-0.5-1.71.1-0.30.8-0.70.80.90.80.8-0.8-0.20.4-0.20.2-0.20.40.0-0.00.10.1-0.1-0.1-0.3-1.5
Locomotion velocity, session 70.91.01.7-1.0-1.01.0-1.21.1-1.01.30.91.31.3-1.3-1.00.9-1.01.0-1.00.8-0.9-0.8-0.9-0.90.90.9-0.30.6
Locomotion distance, session 70.60.81.5-1.0-1.21.2-1.00.9-1.01.10.71.11.1-1.1-0.90.9-0.90.9-0.90.8-0.7-0.7-0.7-0.70.70.70.10.2
Stereotopy head waving bouts, day 70.10.10.3-0.4-0.40.40.4-0.5-0.20.3-0.40.30.3-0.30.20.40.2-0.20.20.2-0.2-0.1-0.2-0.10.20.1-0.20.1
Stereotopy head waving duration, day 70.20.31.00.1-0.30.01.0-0.90.3-0.3-0.8-0.3-0.30.30.7-0.20.7-0.70.7-0.30.40.40.40.5-0.4-0.5-0.3-0.5
Locomotion velocity, session 80.70.84.0-0.6-0.60.6-1.11.2-0.70.51.30.50.5-0.5-1.00.7-1.01.0-1.00.8-0.8-0.9-0.8-0.80.80.8-2.00.7
Locomotion distance, session 80.50.70.9-0.9-0.80.9-0.90.9-0.90.80.80.80.8-0.8-1.00.9-1.01.0-1.00.8-0.8-0.8-0.9-0.80.90.8-0.30.8
Degree of sensitization distance1.01.02.41.20.3-0.80.7-0.30.9-1.1-0.3-1.1-1.11.10.9-1.10.9-0.90.9-1.11.21.11.21.2-1.3-1.20.4-1.5
Degree of sensitization stereotypy0.10.20.6-0.6-0.10.30.3-0.5-0.20.1-0.40.10.1-0.1-0.00.5-0.10.1-0.10.4-0.4-0.4-0.5-0.40.50.4-0.70.8
Conditioned locomotion1.11.32.81.41.7-1.61.2-0.71.2-1.3-0.5-1.3-1.31.41.2-1.31.2-1.21.2-1.10.90.91.00.9-1.0-0.90.8-0.4
Cocaine response after cond. corrected1.61.84.01.50.6-1.11.1-0.81.2-1.8-0.6-1.9-1.92.01.0-1.41.0-1.01.0-1.31.41.31.51.4-1.5-1.40.1-1.7
Cocaine response after cond. not corrected1.11.22.81.10.3-0.70.8-0.30.8-1.4-0.3-1.5-1.51.60.9-1.10.9-0.90.9-1.01.11.11.21.1-1.2-1.10.8-1.7
Cocaine response before conditioning0.50.61.2-1.1-0.60.9-0.70.9-1.00.90.70.90.9-1.0-0.50.9-0.50.5-0.50.9-0.9-0.8-0.9-0.80.90.80.90.6
Saline control response0.30.41.3-0.80.40.2-0.5-0.2-0.60.2-0.10.30.3-0.3-0.40.6-0.40.4-0.40.7-0.9-0.8-0.9-0.80.90.80.91.1
Bone: connectivity density0.40.72.5-0.9-1.51.2-0.80.7-0.80.60.70.50.5-0.5-0.90.9-0.90.9-0.90.8-0.5-0.6-0.5-0.50.60.5-1.6-0.1
Bone: cortical apparent density1.01.32.3-1.2-1.51.4-1.40.9-1.11.30.71.41.4-1.4-1.31.2-1.31.3-1.31.0-0.8-0.9-0.9-0.90.90.9-1.10.5
Bone: cortical area2.03.03.7-1.9-1.71.8-1.71.8-1.91.91.81.91.9-1.9-1.71.8-1.71.7-1.71.8-1.7-1.7-1.7-1.61.71.6-1.01.0
Bone: cortical porosity0.10.10.9-0.50.00.20.1-0.2-0.20.1-0.10.10.1-0.2-0.00.4-0.00.0-0.00.3-0.4-0.4-0.5-0.40.50.4-0.70.9
Bone: cortical porosity0.60.61.5-1.0-0.50.7-0.40.2-0.70.60.30.70.7-0.7-0.60.9-0.60.6-0.60.8-0.9-0.9-1.0-0.91.00.9-1.21.2
Bone: cortical thickness1.93.24.1-2.0-1.71.8-1.81.9-1.82.01.92.02.0-2.0-1.71.8-1.71.7-1.71.8-1.7-1.8-1.7-1.71.71.7-1.41.1
Bone: cortical thickness4.24.86.3-2.5-2.52.5-2.32.2-2.42.42.32.22.2-2.2-2.32.3-2.32.3-2.32.3-2.0-2.1-2.0-2.02.02.0-1.71.1
Bone: cortical tissue density0.91.22.3-1.2-1.51.4-1.40.9-1.01.20.71.31.3-1.3-1.31.1-1.31.3-1.31.0-0.8-0.8-0.8-0.80.80.8-1.20.5
Condit. Reinf. active minus inactive responses4.85.48.4-2.3-2.52.5-2.92.7-2.42.52.52.52.5-2.5-2.62.3-2.62.6-2.62.2-2.0-2.1-2.0-2.02.02.0-1.51.0
Condit. Reinf. active-inactive response ratio2.93.25.0-1.9-2.22.1-2.01.9-1.91.91.61.91.9-2.0-1.91.8-1.91.9-1.91.8-1.5-1.5-1.5-1.51.51.5-1.40.5
Condit. Reinf. active responses4.65.78.5-2.4-2.42.5-2.92.8-2.42.62.62.72.7-2.7-2.62.3-2.62.6-2.62.3-2.1-2.2-2.1-2.22.12.1-1.21.2
Condit. Reinf. inactive responses1.61.92.9-1.3-1.21.3-1.61.5-1.41.51.71.61.6-1.6-1.41.3-1.41.4-1.41.3-1.3-1.3-1.2-1.31.21.3-0.80.8
Incentive salience index mean5.06.09.9-2.4-2.42.5-3.22.9-2.52.52.72.52.5-2.5-2.82.3-2.82.8-2.82.3-2.2-2.2-2.2-2.22.22.2-1.51.3
Condit. Reinf. lever presses1.11.53.2-1.0-0.50.8-1.81.6-1.00.91.41.01.0-1.0-1.51.0-1.51.5-1.51.1-1.2-1.2-1.2-1.21.21.2-0.71.2
Condit. Reinf. active minus inactive responses1.21.52.5-1.6-0.61.1-1.10.4-1.41.40.61.51.5-1.5-1.01.3-1.01.0-1.01.3-1.5-1.3-1.4-1.31.41.31.11.2
Condit. Reinf. active-inactive response ratio0.40.40.9-0.8-0.40.6-0.60.3-0.80.80.60.80.8-0.8-0.50.6-0.50.5-0.50.7-0.8-0.7-0.7-0.70.70.70.90.4
Condit. Reinf. active responses0.60.81.5-1.2-0.71.0-0.80.2-1.10.90.21.01.0-1.0-0.71.0-0.70.7-0.71.0-1.0-0.8-0.9-0.90.90.91.20.6
Condit. Reinf. inactive responses0.20.31.40.40.4-0.30.5-0.80.4-0.5-1.1-0.4-0.40.50.5-0.40.5-0.50.5-0.40.40.50.40.5-0.4-0.51.2-0.4
Condit. Reinf. lever presses0.50.71.3-1.1-0.30.7-0.70.5-1.01.00.41.01.0-0.9-0.60.9-0.50.5-0.51.0-1.0-0.9-1.0-0.91.00.90.80.8
Condit. Reinf. lever reinforcers received0.40.51.8-1.0-0.30.7-0.70.1-0.90.70.10.70.7-0.7-0.50.8-0.50.5-0.50.8-0.9-0.7-0.8-0.80.80.81.30.6
Conditioned reinforcement - actives2.22.24.0-1.7-2.02.0-1.70.9-1.71.60.91.71.7-1.7-1.71.7-1.61.6-1.61.5-1.3-1.3-1.3-1.31.31.2-0.20.4
Conditioned reinforcement - inactives0.60.62.0-0.50.50.0-0.90.6-0.50.60.60.60.6-0.6-1.00.6-0.80.8-0.80.8-1.0-1.0-1.0-1.01.01.0-0.21.4
Conditioned locomotion0.70.81.4-1.0-0.60.9-1.20.9-1.00.50.80.50.5-0.4-1.11.0-1.01.0-1.01.1-1.0-1.0-1.0-1.01.01.0-0.10.7
Patch foraging indifference point 0 sec2.23.59.1-2.1-3.02.5-2.02.5-2.11.62.51.61.6-1.6-1.81.9-1.81.8-1.81.9-1.3-1.5-1.3-1.41.31.4-2.4-0.3
Patch foraging indifference point AUC0.20.33.50.21.1-0.5-0.1-0.10.00.1-0.20.10.1-0.0-0.1-0.1-0.00.0-0.0-0.0-0.4-0.2-0.3-0.30.30.31.90.9
Delay disc. indifference point, 0s delay1.61.72.3-1.5-1.31.5-1.50.8-1.31.30.41.41.4-1.5-1.41.5-1.41.4-1.41.3-1.3-1.2-1.4-1.31.41.3-0.61.3
Delay disc. indifference point, 16s delay0.00.00.10.1-0.20.1-0.0-0.10.1-0.2-0.3-0.2-0.20.10.2-0.00.1-0.10.1-0.10.20.20.10.2-0.1-0.2-0.3-0.1
Delay disc. indifference point, 2s delay0.10.10.30.00.00.1-0.3-0.30.0-0.1-0.5-0.1-0.1-0.0-0.40.1-0.50.5-0.5-0.1-0.10.0-0.2-0.00.10.00.40.5
Delay disc. indifference point, 24s delay0.40.40.80.60.4-0.50.5-0.50.6-0.7-0.8-0.8-0.80.90.4-0.60.3-0.30.3-0.60.60.70.60.6-0.6-0.60.5-0.4
Delay disc. indifference point, 4s delay0.60.61.0-0.9-0.50.8-0.6-0.5-0.60.8-0.80.80.8-0.9-0.80.9-0.90.9-0.90.6-0.7-0.6-0.8-0.60.80.70.91.0
Delay disc. indifference point, 8s delay0.70.71.4-0.8-0.60.8-1.00.8-0.80.90.40.90.9-0.8-0.80.9-0.80.8-0.80.8-0.9-0.8-1.0-0.91.00.9-0.61.2
Indifference point function ln k2.02.78.0-2.0-2.42.1-1.41.8-1.71.51.91.41.4-1.2-1.51.8-1.51.5-1.51.6-1.3-1.5-1.4-1.41.41.4-2.80.7
Indifference point function log k2.02.78.0-2.0-2.42.1-1.41.8-1.71.51.91.41.4-1.2-1.51.8-1.51.5-1.51.6-1.3-1.5-1.4-1.41.41.4-2.80.7
Patch foraging total patch changes 0 sec1.83.07.5-1.9-2.72.2-1.72.3-1.91.52.41.51.5-1.5-1.61.7-1.61.6-1.61.7-1.2-1.4-1.2-1.31.21.3-2.4-0.2
Patch foraging total patch changes 12 sec0.10.10.8-0.6-0.10.3-0.10.6-0.50.40.60.30.3-0.30.00.30.0-0.00.00.4-0.4-0.4-0.3-0.40.30.40.9-0.0
Patch foraging total patch changes 18 sec0.70.82.4-0.8-1.51.3-1.50.9-1.10.60.90.60.6-0.6-1.20.8-1.31.3-1.30.8-0.6-0.6-0.6-0.60.50.60.2-0.2
Patch foraging total patch changes 24 sec3.44.17.9-2.1-1.61.9-2.62.8-2.21.72.61.61.6-1.7-2.22.0-2.22.2-2.22.2-2.1-2.1-1.9-2.11.92.1-0.71.1
Patch foraging total patch changes 6 sec0.40.61.4-0.7-1.00.9-1.21.1-0.90.71.00.70.7-0.5-1.00.7-0.90.9-0.90.7-0.6-0.7-0.6-0.70.60.7-0.40.1
Patch foraging time to switch 0 sec3.96.18.52.92.1-2.52.1-2.12.6-2.9-2.1-2.9-2.92.82.2-2.62.2-2.22.2-2.62.62.52.62.6-2.6-2.51.3-2.2
Patch foraging water rate 0 sec4.87.812.5-3.4-3.53.4-2.42.8-3.13.22.73.13.1-3.0-2.53.0-2.52.5-2.52.9-2.6-2.6-2.6-2.62.62.6-2.21.3
Patch foraging water rate 12 sec13.620.727.1-5.2-5.25.2-4.54.9-4.94.74.74.74.7-4.7-4.44.8-4.44.4-4.44.7-4.3-4.4-4.3-4.34.34.3-4.12.4
Patch foraging water rate 18 sec10.414.021.7-4.1-4.24.1-3.94.7-3.93.84.63.83.8-3.8-3.73.8-3.63.6-3.63.8-3.3-3.5-3.3-3.43.33.4-3.81.6
Patch foraging water rate 24 sec2.83.96.8-2.0-2.52.3-1.72.6-2.12.32.52.22.2-2.3-1.81.9-1.81.8-1.81.9-1.6-1.7-1.6-1.71.61.7-1.70.6
Patch foraging water rate 6 sec13.319.526.3-5.1-4.34.6-4.24.7-4.64.84.64.64.6-4.7-4.14.6-4.14.1-4.14.5-4.4-4.4-4.4-4.44.44.4-3.63.3
Seeking ratio, delayed vs. immediate footshock0.80.93.11.1-0.3-0.40.6-0.40.8-1.0-0.2-1.1-1.11.10.5-1.00.5-0.50.5-1.01.31.21.31.2-1.3-1.30.0-1.8
Distance traveled before self-admin0.91.04.2-1.2-2.01.6-0.81.0-1.21.20.81.21.2-1.1-0.81.0-0.80.8-0.81.0-0.5-0.5-0.4-0.40.40.40.1-1.1
Distance traveled after self-admin1.82.06.0-1.6-2.42.1-1.51.0-1.61.61.21.71.7-1.6-1.41.5-1.51.5-1.51.3-0.9-1.0-1.0-1.00.91.0-1.0-0.1
Extensor digitorum longus weight1.87.110.6-2.8-3.13.0-2.53.1-2.82.93.32.82.8-2.7-2.52.7-2.52.5-2.52.7-2.4-2.5-2.4-2.42.42.4-2.91.1
Bone: elastic displacement0.20.30.7-0.4-0.70.6-0.50.5-0.40.70.60.70.7-0.7-0.50.4-0.50.5-0.50.4-0.3-0.4-0.3-0.40.30.4-0.90.0
Bone: elastic work2.93.86.0-2.1-2.42.3-2.11.9-2.22.22.12.12.1-2.1-2.02.0-2.02.0-2.02.0-1.7-1.8-1.7-1.71.71.7-1.10.6
Bone: endosteal estimation0.10.30.90.60.5-0.50.5-0.40.3-0.6-0.4-0.6-0.60.70.4-0.40.4-0.40.4-0.40.40.40.40.5-0.4-0.51.0-0.6
Bone: endosteal perimeter0.10.20.4-0.4-0.40.5-0.60.6-0.60.40.60.30.3-0.3-0.60.5-0.60.6-0.60.5-0.5-0.5-0.5-0.50.50.40.30.1
Epididymis fat weight0.10.32.6-0.01.2-0.60.3-0.20.2-0.5-0.0-0.4-0.40.20.2-0.20.2-0.20.2-0.1-0.4-0.2-0.4-0.40.40.40.61.6
Delta time in closed arm before/after self-admin0.40.43.00.91.7-1.30.5-0.20.7-0.3-0.1-0.5-0.50.50.4-0.70.4-0.40.4-0.50.10.10.20.1-0.2-0.10.80.6
Delta time in open arm before/after self-admin0.20.21.2-0.6-0.80.6-0.30.5-0.4-0.10.5-0.2-0.20.3-0.10.4-0.10.1-0.10.3-0.2-0.2-0.3-0.20.30.2-1.10.0
Diff in mean of infusions in LGA sessions0.80.81.51.10.7-0.91.0-1.21.0-1.0-0.8-1.0-1.00.90.9-0.90.9-0.90.9-0.90.90.90.90.9-0.9-0.9-0.4-0.8
Delay discount exponential model param0.10.10.70.30.0-0.20.3-0.10.2-0.20.4-0.2-0.20.20.3-0.30.4-0.40.4-0.20.30.20.40.3-0.4-0.3-0.0-0.8
Extinction: sum of active levers before priming0.20.21.10.3-0.30.10.4-0.80.10.2-0.50.30.3-0.30.1-0.20.1-0.10.1-0.20.40.40.50.5-0.5-0.50.9-1.1
Active lever presses in extinction session 61.41.32.71.20.4-0.81.3-1.41.0-1.0-1.2-0.8-0.80.81.2-1.01.3-1.31.3-1.11.31.31.31.3-1.3-1.30.7-1.6
Bone: final force3.65.87.8-2.5-1.92.3-2.62.6-2.52.62.82.62.6-2.6-2.52.4-2.52.5-2.52.5-2.4-2.4-2.4-2.42.42.4-1.51.6
Bone: final moment3.35.37.3-2.4-2.02.2-2.52.6-2.42.42.72.52.5-2.4-2.42.3-2.42.4-2.42.4-2.3-2.3-2.2-2.32.22.2-1.61.4
Food consumed during 24 hour testing period7.38.810.7-3.2-2.83.1-3.32.6-3.02.92.52.92.9-2.8-3.33.1-3.33.3-3.33.1-2.9-3.0-3.0-3.03.03.0-2.82.3
Glucose0.30.51.0-0.6-0.90.8-0.90.8-0.80.31.00.30.3-0.2-0.80.7-0.80.8-0.80.7-0.6-0.6-0.6-0.70.60.7-0.80.2
Heart weight2.02.913.1-1.7-1.91.7-1.62.1-1.51.32.11.31.3-1.3-1.61.7-1.61.6-1.61.6-1.3-1.5-1.4-1.41.41.4-3.60.8
Delay discount hyperbolic model param0.20.20.80.40.1-0.40.5-0.10.3-0.30.3-0.3-0.30.30.5-0.40.6-0.60.6-0.30.50.40.50.4-0.5-0.4-0.0-0.9
Intermittent access intake day 1-15 change0.60.61.2-0.7-0.90.9-1.10.1-0.60.90.10.90.9-0.9-1.10.8-1.01.0-1.00.6-0.5-0.5-0.6-0.50.60.5-0.70.3
Intermittent access intake escalation0.40.40.9-0.6-0.80.8-0.9-0.3-0.50.7-0.10.80.8-0.8-1.00.6-0.80.8-0.80.5-0.4-0.3-0.4-0.30.40.3-0.50.2
Intermittent access intake escalation 21.41.42.4-1.2-1.41.5-1.50.4-1.21.20.41.21.2-1.3-1.51.3-1.51.5-1.51.1-1.0-0.9-1.0-0.91.00.9-0.50.6
Intermitt. access day 1 inactive lever presses0.40.51.41.21.1-1.00.5-0.20.9-0.4-0.5-0.5-0.50.40.3-0.90.4-0.40.4-0.80.70.80.80.8-0.7-0.80.6-0.5
Intermitt. access day 15 inactive lever presses0.60.72.2-0.50.7-0.1-0.81.1-0.60.81.50.60.6-0.6-0.80.5-0.70.7-0.70.7-1.0-1.0-1.0-1.01.01.00.01.2
Intermitt. access escalation Index0.10.10.90.01.0-0.60.2-0.10.3-0.2-0.3-0.3-0.30.20.1-0.10.2-0.20.2-0.1-0.1-0.1-0.2-0.10.20.2-0.31.0
Intermittent access day 1 total infusions1.11.21.81.31.2-1.41.3-0.71.2-1.2-0.4-1.2-1.21.11.2-1.21.3-1.31.3-1.11.11.01.11.0-1.1-1.00.3-0.9
Intermittent access day 15 total infusions0.30.40.80.80.3-0.50.3-0.60.6-0.7-0.5-0.6-0.60.50.1-0.60.4-0.40.4-0.60.70.70.70.8-0.7-0.80.3-0.9
Intermittent access terminal intake (last 3 days)0.00.00.2-0.00.2-0.1-0.40.2-0.10.10.30.20.2-0.3-0.50.1-0.20.2-0.20.1-0.1-0.1-0.1-0.10.10.10.0-0.0
Intermittent access total infusions0.60.71.50.90.4-0.70.7-0.80.7-0.8-0.7-0.7-0.70.70.7-0.80.8-0.80.8-0.80.90.90.90.9-0.9-0.90.9-1.2
Intermittent access day 1 locomotion1.61.72.31.51.4-1.51.4-0.91.3-1.5-0.9-1.5-1.51.51.3-1.31.4-1.41.4-1.21.21.11.21.2-1.2-1.21.1-0.9
Intermittent access day 15 total locomotion0.50.50.90.90.5-0.70.6-0.70.7-0.8-0.5-0.7-0.70.70.8-0.70.7-0.70.7-0.70.80.70.80.8-0.8-0.80.7-1.0
Intermittent access total locomotion0.10.10.30.30.3-0.30.2-0.00.2-0.50.1-0.5-0.50.50.4-0.30.4-0.40.4-0.20.20.20.30.3-0.3-0.30.6-0.5
Intermittent access standard deviation0.10.10.60.50.5-0.3-0.0-0.80.4-0.2-0.7-0.3-0.30.3-0.0-0.20.0-0.00.0-0.30.20.20.20.3-0.1-0.20.00.2
Left kidney weight1.54.26.7-1.9-1.01.6-2.02.4-2.12.32.62.22.2-2.2-2.01.9-2.02.0-2.02.0-2.3-2.2-2.2-2.22.22.2-0.62.1
Right kidney weight1.95.37.0-2.5-1.52.1-2.02.3-2.42.62.62.62.6-2.4-2.12.3-2.12.1-2.12.3-2.5-2.4-2.5-2.52.52.5-1.32.4
Cocaine induced anxiety0.91.12.51.20.5-1.01.1-0.00.9-1.00.3-1.0-1.01.01.0-1.21.2-1.21.2-1.01.21.01.21.1-1.3-1.10.4-1.6
Post-drug Anxiety0.40.52.30.6-0.2-0.30.70.40.4-0.60.6-0.5-0.50.50.6-0.70.8-0.80.8-0.60.80.70.90.7-0.9-0.80.1-1.5
Baseline Anxiety0.91.01.6-1.3-0.91.1-1.20.8-1.00.70.80.70.7-0.8-1.11.1-1.11.1-1.11.0-1.0-1.0-1.0-1.01.01.0-1.00.9
Tail length2.47.211.0-3.3-1.82.5-2.52.1-2.82.71.92.72.7-2.7-2.73.0-2.72.7-2.73.0-3.0-2.9-3.0-2.93.02.9-1.12.6
Length with tail1.55.68.2-2.9-1.52.1-1.91.9-2.42.42.12.42.4-2.4-2.12.6-2.12.1-2.12.6-2.7-2.7-2.7-2.72.72.7-1.52.7
Length without tail0.00.10.3-0.20.00.10.4-0.1-0.10.40.20.40.4-0.30.20.10.2-0.20.20.0-0.2-0.1-0.2-0.20.20.20.10.5
Times rat made contact with spout0.30.42.30.51.5-1.20.40.10.6-0.80.2-0.9-0.90.90.5-0.60.5-0.50.5-0.30.0-0.00.1-0.0-0.00.1-0.30.8
Lifetime Intake1.11.33.21.20.3-0.70.9-1.30.9-1.1-1.1-1.0-1.00.90.9-1.11.0-1.01.0-1.11.31.31.31.3-1.3-1.41.1-1.8
Liver weight, left0.00.10.3-0.20.4-0.10.10.1-0.10.30.10.30.3-0.30.10.10.1-0.10.10.1-0.3-0.2-0.2-0.30.20.30.50.5
Liver weight, right0.10.20.7-0.4-0.20.3-0.30.7-0.40.70.80.70.7-0.7-0.20.3-0.20.2-0.20.4-0.4-0.4-0.4-0.40.40.4-0.20.2
Locomotor activity2.64.212.4-1.6-2.01.8-3.03.5-2.01.23.51.31.3-1.4-2.51.6-2.42.4-2.41.8-1.6-1.8-1.5-1.71.51.7-2.10.5
Locomotor testing distance5.59.217.9-3.1-3.23.1-3.84.2-3.32.44.22.42.4-2.4-3.42.9-3.33.3-3.33.1-2.8-2.9-2.7-2.92.72.9-2.41.1
Locomotor testing rearing4.87.414.1-2.9-2.32.6-3.03.5-3.02.73.82.72.7-2.8-2.72.6-2.62.6-2.62.9-2.8-2.8-2.6-2.82.62.7-1.11.4
Locomotion in novel chamber1.11.42.91.01.2-1.11.4-1.71.0-1.2-1.7-1.2-1.21.31.5-0.91.6-1.61.6-0.90.80.90.80.9-0.8-0.91.0-0.4
Locomotion in novel chamber post-restriction0.50.61.60.80.5-0.70.80.10.7-1.30.0-1.1-1.11.10.9-0.70.8-0.80.8-0.60.60.50.60.5-0.6-0.5-0.8-0.4
Fecal boli incidents, locomotor time 10.20.31.0-0.5-1.00.60.10.5-0.30.90.50.90.9-1.00.30.30.2-0.20.20.10.10.00.00.1-0.0-0.1-0.4-0.6
Change in fecal boli incidents, locomotor task1.51.52.51.51.0-1.20.9-1.01.2-1.6-1.0-1.5-1.51.60.9-1.31.0-1.01.1-1.31.21.21.31.2-1.3-1.20.7-1.0
Time >=10cm from walls, locomotor time 11.01.02.31.10.2-0.70.8-0.40.8-1.40.0-1.5-1.51.40.7-1.10.7-0.70.7-1.01.11.11.21.1-1.2-1.10.1-1.4
Bouts of movement, locomotor time 15.25.77.62.72.7-2.82.5-2.22.7-2.5-2.2-2.5-2.52.52.4-2.52.5-2.52.5-2.42.32.32.32.3-2.3-2.31.5-1.4
Total resting periods, locomotor time 17.78.511.33.33.2-3.43.0-2.73.2-3.2-2.6-3.2-3.23.22.9-3.12.9-2.92.9-3.02.82.82.82.8-2.8-2.81.7-1.7
Rest time, locomotor task time 18.18.912.33.13.2-3.53.4-2.53.4-3.5-2.3-3.5-3.53.33.0-3.23.0-3.03.0-3.12.92.82.92.8-2.9-2.80.9-1.6
Distance moved, locomotor task time 14.34.76.8-2.1-2.22.4-2.62.3-2.62.12.22.02.0-1.9-2.52.2-2.52.5-2.52.3-2.2-2.1-2.1-2.12.02.1-0.10.9
Vertical activity count, locomotor time 10.90.91.6-1.0-1.21.3-1.10.9-1.31.10.71.01.0-0.9-1.01.1-0.90.9-0.91.1-0.9-0.8-0.9-0.80.80.80.40.0
Time >=10cm from walls, locomotor time 20.10.10.3-0.50.10.1-0.10.3-0.30.10.30.00.0-0.1-0.10.3-0.10.1-0.10.3-0.3-0.3-0.3-0.30.30.30.10.3
Bouts of movement, locomotor time 21.82.04.31.41.0-1.31.4-0.41.4-1.8-0.1-2.1-2.12.01.7-1.31.6-1.61.6-1.31.31.11.21.1-1.1-1.1-1.6-0.5
Total resting periods, locomotor time 23.03.26.21.91.4-1.81.8-0.91.9-2.3-0.6-2.5-2.52.42.1-1.82.0-2.02.0-1.71.71.51.61.6-1.6-1.5-1.4-0.8
Rest time, locomotor task time 26.27.19.12.62.1-2.52.9-2.92.8-3.0-2.6-2.9-2.92.73.0-2.62.9-2.92.9-2.62.72.62.62.7-2.6-2.61.1-2.0
Distance moved, locomotor task time 25.36.28.3-2.5-1.72.3-2.62.5-2.72.72.22.62.6-2.5-2.92.5-2.82.8-2.82.6-2.7-2.5-2.6-2.62.62.6-0.12.0
Vertical activity count, locomotor time 22.73.04.5-1.7-1.21.6-1.61.6-1.62.11.32.02.0-1.9-2.11.7-2.02.0-2.01.6-1.7-1.6-1.7-1.71.71.7-1.01.5
Light reinforcement 13.05.57.0-2.5-1.11.8-2.51.9-2.22.41.82.42.4-2.5-2.52.5-2.52.5-2.52.5-2.6-2.6-2.6-2.52.62.6-1.22.6
Light reinforcement 21.82.45.3-1.7-0.21.0-1.30.6-1.31.90.71.91.9-2.1-1.41.5-1.41.4-1.41.5-1.8-1.7-1.8-1.71.91.70.12.3
Bone: marrow area0.10.20.90.50.4-0.40.5-0.40.3-0.6-0.4-0.7-0.70.70.4-0.40.4-0.40.4-0.30.30.40.40.4-0.4-0.40.9-0.6
Bone: maximum diameter0.50.91.3-1.1-1.11.1-0.90.8-1.11.10.91.11.1-1.1-0.91.0-0.90.9-0.91.0-1.0-0.9-0.9-0.90.90.8-0.00.4
Bone: maximum force1.62.83.7-1.8-1.31.6-1.81.6-1.81.91.81.91.9-1.8-1.71.7-1.71.7-1.71.7-1.7-1.7-1.7-1.71.71.7-0.61.2
Bone: maximum moment1.42.43.0-1.7-1.31.5-1.61.6-1.61.71.71.71.7-1.7-1.61.6-1.61.6-1.61.6-1.6-1.5-1.5-1.51.51.5-0.61.0
Mean time between licks in bursts1.21.73.41.41.4-1.41.3-1.11.3-1.2-1.3-1.2-1.21.31.3-1.41.3-1.31.3-1.41.21.31.21.2-1.2-1.31.8-0.8
Mean num. licks in bursts2.32.74.1-1.7-0.61.2-1.71.6-1.61.41.61.41.4-1.5-1.71.7-1.71.7-1.71.7-1.9-1.9-1.9-1.91.91.9-0.82.0
Cd content in liver1.71.93.61.31.6-1.51.7-1.91.4-1.1-1.9-1.1-1.11.11.6-1.21.6-1.61.6-1.31.21.21.11.3-1.1-1.21.5-0.6
Co content in liver0.40.51.00.70.6-0.60.7-0.90.6-0.7-0.8-0.8-0.80.70.7-0.70.7-0.70.7-0.60.60.70.70.6-0.7-0.61.0-0.6
Cu content in liver0.60.74.90.62.2-1.51.1-0.80.8-0.3-0.7-0.3-0.30.31.0-0.71.0-1.01.0-0.60.10.20.10.1-0.1-0.11.21.1
Fe content in liver0.91.03.60.91.4-1.11.6-1.91.1-0.3-1.8-0.4-0.40.41.2-0.81.2-1.21.2-0.90.70.80.60.8-0.6-0.70.70.3
K content in liver0.60.61.40.71.2-0.91.2-1.00.8-0.6-1.0-0.5-0.50.51.0-0.71.0-1.01.0-0.70.50.60.50.5-0.5-0.51.10.1
Mg content in liver0.30.31.50.10.8-0.50.9-0.90.3-0.3-0.9-0.3-0.30.30.7-0.20.7-0.70.7-0.20.10.20.10.2-0.1-0.21.20.2
Mn content in liver1.51.73.7-1.6-1.91.8-0.91.0-1.61.51.01.61.6-1.5-1.11.5-1.11.1-1.11.4-1.2-1.1-1.2-1.11.21.1-0.00.3
Na content in liver0.60.71.8-1.0-0.91.0-0.50.4-0.91.30.41.31.3-1.3-0.50.8-0.40.4-0.40.7-0.7-0.6-0.7-0.60.60.61.10.1
Rb content in liver1.11.44.01.11.5-1.31.4-1.41.1-1.1-1.4-1.2-1.21.21.2-1.11.2-1.21.2-1.10.81.00.90.9-0.9-0.92.0-0.4
Se content in liver1.92.43.31.81.2-1.51.8-1.31.5-1.6-1.2-1.6-1.61.61.6-1.61.6-1.61.6-1.51.61.51.61.6-1.6-1.60.8-1.5
Sr content in liver2.01.83.4-1.2-0.71.0-1.51.8-1.21.31.81.31.3-1.3-1.31.2-1.31.3-1.31.3-1.3-1.4-1.3-1.41.31.4-1.51.1
Zn content in liver0.10.20.5-0.10.3-0.1-0.60.7-0.20.20.70.30.3-0.3-0.50.2-0.50.5-0.50.4-0.4-0.5-0.3-0.40.30.4-0.50.2
Bone: minimum diameter0.71.21.9-1.4-0.91.1-0.90.9-1.21.30.81.21.2-1.2-1.01.3-1.01.0-1.01.3-1.2-1.2-1.2-1.11.21.1-0.90.9
Time in familiar zone, hab. session 10.80.81.4-0.7-0.20.5-1.01.1-0.71.01.01.01.0-1.0-1.00.7-1.01.0-1.00.8-0.9-0.9-0.9-0.90.90.9-0.41.2
Time in novel zone, hab. session 11.31.32.40.90.2-0.61.4-1.60.9-1.0-1.2-1.0-1.01.01.3-0.91.3-1.31.3-1.01.31.21.21.2-1.2-1.20.3-1.5
Total zone transitions, hab. session 10.30.41.7-0.1-0.80.6-1.31.2-0.60.21.00.20.2-0.2-1.00.3-1.01.0-1.00.3-0.2-0.2-0.1-0.20.10.10.7-0.8
Total locomotion distance, hab. session 10.30.41.1-0.4-0.80.7-1.00.7-0.70.70.60.70.7-0.7-0.80.5-0.80.8-0.80.5-0.4-0.3-0.3-0.30.30.31.0-0.5
Locomotion velocity, hab. session 10.10.11.90.20.0-0.1-0.40.2-0.10.10.00.10.1-0.1-0.2-0.2-0.20.2-0.2-0.10.10.20.20.2-0.2-0.21.4-0.6
Time in familiar zone, hab. session 20.00.00.2-0.30.10.10.2-0.2-0.10.1-0.40.10.1-0.1-0.00.2-0.00.0-0.00.2-0.2-0.2-0.2-0.20.30.20.10.5
Time in novel zone, hab. session 20.10.10.40.4-0.2-0.10.10.00.2-0.20.1-0.2-0.20.20.2-0.30.2-0.20.2-0.30.40.40.40.4-0.4-0.4-0.4-0.6
Total zone transitions, hab. session 21.62.15.0-1.3-1.71.6-2.02.2-1.61.02.11.01.0-1.0-1.81.3-1.81.8-1.81.4-1.2-1.2-1.1-1.21.11.2-0.50.1
Total locomotion distance, hab. session 21.01.42.5-1.2-1.61.4-1.51.5-1.31.01.41.01.0-1.0-1.41.2-1.41.4-1.41.1-0.9-0.9-0.9-0.90.90.9-0.80.2
Locomotion velocity, hab. session 20.70.91.6-0.9-1.11.0-1.31.3-1.00.81.10.80.8-0.8-1.20.9-1.21.2-1.20.9-0.8-0.8-0.8-0.80.80.7-0.30.2
Novel to familiar place preference ratio2.12.24.11.41.6-1.51.8-1.61.3-1.5-1.5-1.5-1.51.51.7-1.41.7-1.71.7-1.31.21.31.21.2-1.2-1.22.0-0.7
Novelty place preference1.71.72.71.31.6-1.41.6-1.41.2-1.4-1.3-1.3-1.31.31.5-1.31.5-1.51.5-1.21.01.11.01.1-1.0-1.11.6-0.5
Time in novel zone, NPP test2.02.13.01.41.5-1.51.7-1.51.3-1.5-1.4-1.5-1.51.51.7-1.41.7-1.71.7-1.31.21.31.21.3-1.2-1.31.5-0.8
Total zone transitions, NPP test0.20.21.50.2-0.60.3-0.60.7-0.2-0.30.5-0.3-0.30.3-0.3-0.1-0.30.3-0.3-0.10.30.30.40.3-0.4-0.41.0-1.2
Total locomotion distance, NPP test0.60.91.7-1.0-1.31.2-1.21.2-1.11.01.01.01.0-1.0-1.00.8-1.01.0-1.00.8-0.7-0.6-0.6-0.60.60.60.8-0.3
Locomotion velocity, NPP test1.11.62.5-1.4-1.61.5-1.51.5-1.51.31.31.41.4-1.4-1.31.2-1.31.3-1.31.2-1.1-1.0-1.0-1.01.01.00.70.1
Intraocular pressure1.31.84.7-1.3-2.21.7-1.72.0-1.61.02.01.01.0-1.0-1.51.3-1.51.5-1.51.3-0.8-0.9-0.7-0.80.70.8-0.6-0.9
Delta distance traveled before/after self-admin1.01.12.3-1.0-0.91.0-1.20.5-0.90.90.90.90.9-0.9-1.21.0-1.31.3-1.30.9-1.0-1.0-1.0-1.01.01.1-1.51.2
Delta ambulatory time before/after self-admin0.70.71.3-0.9-0.90.9-1.00.5-0.80.70.90.80.8-0.8-1.00.8-1.01.0-1.00.7-0.8-0.8-0.8-0.80.80.8-1.10.9
Parametrial fat weight1.32.55.81.62.4-2.21.8-0.91.6-1.7-0.7-1.9-1.91.81.8-1.71.8-1.81.8-1.51.21.21.21.2-1.2-1.21.4-0.4
Pavlov. Cond. lever latency1.21.53.51.11.6-1.41.4-1.81.3-1.0-1.9-1.0-1.01.01.2-1.11.2-1.21.2-1.21.01.11.01.0-0.9-1.01.5-0.2
Pavlov. Cond. magazine entry latency0.70.92.6-1.3-1.61.5-0.70.4-1.01.10.31.11.1-1.1-0.81.2-0.80.8-0.80.9-0.8-0.7-0.9-0.80.90.7-0.80.5
Pavlov. Cond. change in total contacts3.23.44.8-2.2-2.12.2-1.81.7-2.11.91.81.91.9-1.9-1.82.0-1.81.8-1.81.9-1.9-1.8-1.9-1.91.81.8-1.01.2
Pavlov. Cond. index score1.62.04.4-1.7-2.12.0-1.31.2-1.61.41.21.41.4-1.4-1.41.6-1.41.4-1.41.4-1.3-1.2-1.3-1.31.31.2-1.10.6
Pavlov. Cond. latency score1.62.04.7-1.7-2.22.0-1.41.4-1.61.31.51.31.3-1.3-1.41.6-1.41.4-1.41.5-1.2-1.2-1.2-1.21.21.2-1.30.4
Pavlov. Cond. lever contacts1.11.32.9-1.2-1.71.5-1.21.3-1.21.01.41.01.0-1.0-1.21.1-1.21.2-1.21.1-0.9-1.0-1.0-1.00.91.0-1.50.4
Pavlov. Cond. magazine entry number1.82.33.81.91.9-1.91.3-1.11.7-1.6-1.0-1.6-1.61.71.4-1.71.4-1.41.4-1.51.51.41.51.5-1.5-1.41.0-1.2
Pavlov. Cond. intertrial magazine entries2.63.25.2-1.6-1.41.6-2.32.0-1.61.72.01.71.7-1.7-2.11.7-2.12.1-2.11.7-1.6-1.7-1.6-1.71.61.7-1.91.3
Pavlov. Cond. lever-magazine prob. diff.1.11.42.9-1.5-1.71.6-1.00.9-1.41.21.01.21.2-1.2-1.11.4-1.11.1-1.11.2-1.1-1.1-1.1-1.11.11.1-0.90.6
Pavlov. Cond. response bias2.22.74.5-1.9-2.12.1-1.61.4-1.71.71.31.71.7-1.7-1.61.8-1.61.6-1.61.6-1.5-1.5-1.6-1.51.61.5-1.41.1
Pavlov. Cond. lever latency0.40.50.80.90.7-0.80.8-0.90.9-0.7-0.9-0.6-0.60.60.7-0.70.7-0.70.7-0.80.80.70.70.8-0.7-0.70.3-0.4
Pavlov. Cond. magazine entry latency0.10.11.20.11.1-0.70.2-0.10.30.1-0.10.00.0-0.00.2-0.20.2-0.20.2-0.1-0.2-0.1-0.2-0.20.20.20.01.0
Pavlov. Cond. change in total contacts0.60.92.4-1.3-1.51.4-0.80.6-1.11.30.51.31.3-1.3-0.61.0-0.60.6-0.60.9-0.7-0.7-0.7-0.70.70.6-0.0-0.1
Pavlov. Cond. index score0.10.10.2-0.4-0.10.2-0.20.3-0.30.30.20.30.3-0.3-0.10.3-0.20.2-0.20.3-0.3-0.3-0.3-0.30.30.3-0.00.2
Pavlov. Cond. latency score0.00.00.1-0.30.10.1-0.10.1-0.10.20.10.20.2-0.2-0.00.2-0.00.0-0.00.2-0.2-0.2-0.2-0.20.20.2-0.10.3
Pavlov. Cond. lever contacts0.30.40.7-0.9-0.60.7-0.70.8-0.90.60.80.50.5-0.5-0.60.7-0.60.6-0.60.7-0.8-0.7-0.7-0.70.70.70.20.3
Pavlov. Cond. magazine entry number0.10.10.30.5-0.0-0.20.20.00.2-0.5-0.0-0.5-0.50.50.2-0.40.2-0.20.2-0.30.40.30.40.4-0.4-0.4-0.1-0.5
Pavlov. Cond. intertrial magazine entries3.44.45.1-2.2-1.92.1-2.32.2-2.22.02.11.91.9-2.0-2.32.2-2.32.3-2.32.2-2.1-2.2-2.1-2.12.12.1-2.01.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.4-0.10.2-0.30.3-0.30.30.30.30.3-0.3-0.20.3-0.20.2-0.20.3-0.3-0.3-0.3-0.30.30.30.00.3
Pavlov. Cond. response bias0.00.10.2-0.4-0.00.2-0.20.3-0.30.20.30.20.2-0.2-0.10.2-0.10.1-0.10.2-0.3-0.2-0.3-0.30.30.30.50.2
Time in closed arm before self-admin0.20.21.0-0.10.00.1-0.5-0.00.10.1-0.4-0.0-0.00.0-1.00.1-1.01.0-1.0-0.1-0.1-0.0-0.2-0.10.20.10.10.8
Time in closed arm after self-admin0.30.32.40.71.5-1.00.0-0.10.7-0.0-0.6-0.2-0.20.3-0.6-0.5-0.60.6-0.6-0.50.10.10.00.1-0.0-0.11.01.0
Time in open arm before self-admin0.40.41.5-0.40.50.0-0.2-0.3-0.41.00.01.11.1-1.2-0.10.4-0.00.0-0.00.5-0.7-0.6-0.6-0.70.60.70.50.8
Time in open arm after self-admin0.60.61.3-1.1-1.21.1-0.70.3-1.00.90.60.90.9-0.9-0.21.0-0.30.3-0.30.9-0.8-0.8-0.8-0.80.80.8-1.00.4
Bone: periosteal estimation0.10.20.4-0.5-0.50.5-0.40.5-0.60.50.50.40.4-0.4-0.40.5-0.40.4-0.40.5-0.5-0.4-0.5-0.40.50.40.5-0.0
Bone: periosteal perimeter0.50.81.4-1.0-1.21.2-0.90.8-1.21.00.81.01.0-1.0-0.91.0-0.90.9-0.91.0-0.9-0.8-0.8-0.80.80.70.30.1
Bone: post-yield work0.00.10.50.20.7-0.40.10.10.2-0.20.0-0.3-0.30.30.1-0.20.1-0.10.1-0.1-0.1-0.1-0.1-0.10.10.10.20.5
Progressive ratio test 1 active lever presses0.20.20.90.5-0.0-0.2-0.00.70.1-0.60.6-0.6-0.60.50.1-0.30.1-0.10.1-0.20.30.30.40.3-0.4-0.40.3-0.9
Progressive ratio test 1 breakpoint0.30.31.40.7-0.0-0.3-0.10.90.2-0.70.8-0.7-0.70.7-0.0-0.50.0-0.00.0-0.30.50.40.50.5-0.6-0.50.1-1.2
Progressive ratio test 1 inactive lever presses0.40.52.10.91.4-1.2-0.0-0.20.8-0.7-0.4-0.7-0.70.7-0.0-0.80.1-0.10.1-0.70.50.50.50.5-0.5-0.51.3-0.2
Progressive ratio test 2 active lever presses0.50.50.9-0.8-0.80.8-0.90.7-0.90.70.80.70.7-0.7-0.80.8-0.80.8-0.80.8-0.7-0.7-0.7-0.70.70.60.7-0.0
Progressive ratio test 2 breakpoint1.11.21.7-1.2-1.11.2-1.31.1-1.31.11.21.11.1-1.2-1.11.2-1.11.1-1.11.2-1.1-1.1-1.0-1.01.01.00.30.3
Progressive ratio test 2 inactive lever presses0.30.31.0-0.5-0.30.4-0.90.7-0.60.40.80.30.3-0.4-1.00.5-0.80.8-0.80.6-0.5-0.5-0.5-0.50.40.50.4-0.0
Incentive Sensitization - Responses2.62.74.6-2.0-1.41.7-1.61.0-1.82.11.42.12.1-2.2-1.31.8-1.41.4-1.41.8-1.7-1.7-1.7-1.71.71.6-0.01.1
Incentive Sensitization - Breakpoint2.62.64.4-2.0-1.31.6-1.51.1-1.82.01.32.12.1-2.1-1.31.8-1.31.3-1.31.8-1.8-1.7-1.7-1.71.71.70.01.2
Sum of active levers in priming session hrs 5-63.02.94.31.71.1-1.51.8-2.11.6-1.6-1.7-1.5-1.51.51.9-1.71.8-1.81.8-1.71.81.81.81.8-1.8-1.81.6-1.9
Progressive ratio0.50.51.20.50.3-0.41.0-0.80.5-0.6-0.8-0.6-0.60.61.1-0.51.1-1.11.1-0.50.60.60.60.6-0.6-0.61.1-0.8
Food seeking constrained by brief footshock0.81.01.9-1.0-0.20.6-0.61.4-1.01.31.01.31.3-1.4-0.60.9-0.60.6-0.61.0-1.2-1.1-1.1-1.11.11.10.21.0
Seeking ratio, punishment vs. effort0.81.01.4-0.8-0.40.6-1.01.2-0.71.11.11.11.1-1.1-1.20.7-1.11.1-1.10.8-0.9-0.9-1.0-0.91.00.9-1.11.1
Retroperitoneal fat weight0.93.08.71.63.0-2.42.0-1.81.8-2.1-1.3-2.1-2.12.02.0-1.82.0-2.02.0-1.51.01.11.01.0-1.0-1.01.20.6
Reaction time number correct0.50.73.1-0.7-1.81.3-1.10.8-1.00.90.80.80.8-0.7-1.00.8-1.01.0-1.00.8-0.4-0.4-0.3-0.40.30.3-0.4-1.0
Reaction time mean minus median0.91.22.81.21.7-1.41.1-1.21.3-1.3-1.2-1.4-1.41.51.1-1.11.0-1.01.0-1.10.80.90.80.8-0.8-0.80.70.2
Reaction time mean minus median AUC1.41.85.61.32.4-1.91.4-1.41.4-1.5-1.3-1.7-1.71.71.4-1.31.4-1.41.4-1.20.80.90.80.8-0.8-0.81.00.5
Reaction time num false alarms1.52.07.2-1.20.60.3-1.51.3-1.01.21.31.31.3-1.4-1.41.1-1.31.3-1.31.2-1.8-1.7-1.7-1.81.71.8-0.52.7
Reaction time num false alarms AUC1.31.85.1-1.10.40.3-1.61.5-0.91.01.51.21.2-1.2-1.41.0-1.41.4-1.41.2-1.6-1.5-1.5-1.61.51.6-0.92.2
Reaction time trials correct on left0.50.73.1-0.7-1.81.3-1.10.8-1.00.90.80.80.8-0.7-1.00.8-1.01.0-1.00.8-0.4-0.4-0.3-0.40.30.3-0.4-1.0
Reaction time trials on left0.50.83.0-0.7-1.71.3-1.10.8-1.00.90.80.80.8-0.7-1.00.8-1.01.0-1.00.8-0.4-0.5-0.3-0.40.30.4-0.4-0.9
Reaction time mean1.01.34.21.02.0-1.51.3-1.61.3-1.3-1.6-1.3-1.31.31.1-1.01.1-1.11.1-1.00.60.70.50.6-0.5-0.51.01.0
Reaction time mean AUC1.01.43.90.92.0-1.41.4-1.71.3-1.3-1.8-1.3-1.31.31.2-1.01.2-1.21.2-1.00.60.70.50.6-0.5-0.61.10.9
Median of all reaction times0.81.13.20.81.8-1.31.2-1.71.1-1.1-1.7-1.0-1.01.01.0-0.81.0-1.01.0-0.90.50.60.40.5-0.4-0.41.01.0
Reaction time omissions0.40.63.20.81.8-1.20.8-1.10.8-0.3-0.9-0.3-0.30.40.8-0.70.8-0.80.8-0.70.30.40.30.3-0.3-0.31.20.8
Reaction time false alarm rate0.60.86.1-0.41.4-0.6-0.70.9-0.10.30.80.50.5-0.6-0.70.3-0.60.6-0.60.5-1.1-1.0-1.1-1.11.11.1-0.72.5
Reaction time premature initiation rate1.92.55.8-1.4-0.81.1-1.31.7-1.31.91.71.81.8-1.8-1.41.5-1.41.4-1.41.5-1.6-1.6-1.6-1.61.71.6-2.41.7
Reaction time premature initiations2.43.45.5-1.7-1.61.7-1.81.9-1.72.31.92.12.1-2.1-1.81.9-1.81.8-1.81.8-1.7-1.8-1.7-1.71.81.7-2.31.2
Std. dev. reaction times0.70.93.40.81.8-1.31.0-1.31.0-0.9-1.3-1.1-1.11.10.9-0.80.9-0.90.9-0.80.40.50.30.4-0.3-0.41.11.0
Reaction time trials completed0.50.83.0-0.7-1.71.3-1.10.8-1.00.90.80.80.8-0.7-1.00.8-1.01.0-1.00.8-0.4-0.5-0.3-0.40.30.4-0.4-0.9
Reaction time trials AUC0.81.23.8-1.0-1.91.6-1.41.1-1.31.21.11.11.1-1.0-1.31.1-1.31.3-1.31.1-0.7-0.8-0.6-0.70.60.7-0.7-0.7
Run reversals in cocaine runway, females2.92.88.2-1.5-1.81.6-1.62.8-1.61.52.91.51.5-1.3-1.41.4-1.51.5-1.51.5-1.4-1.5-1.3-1.51.31.5-2.50.7
Run reversals in cocaine runway, males2.01.93.9-1.3-0.30.9-1.61.1-1.21.01.01.11.1-0.9-1.61.4-1.61.6-1.61.5-1.6-1.6-1.7-1.61.71.6-0.92.0
Latency to leave start box in cocaine runway0.50.51.1-0.8-0.30.6-0.60.9-0.80.61.10.70.7-0.7-0.60.7-0.60.6-0.60.8-0.9-0.9-0.8-0.90.80.9-0.40.8
Latency to leave start box in cocaine runway, F0.10.11.00.00.2-0.1-0.0-0.1-0.1-0.20.1-0.2-0.20.1-0.10.0-0.10.1-0.10.1-0.2-0.1-0.2-0.10.10.11.00.2
Latency to leave start box in cocaine runway, M1.81.73.5-1.6-1.41.4-1.21.4-1.31.41.51.41.4-1.4-1.01.4-1.01.0-1.01.4-1.2-1.3-1.2-1.31.21.3-1.90.7
Std. dev. time between licks in bursts1.82.15.11.50.3-0.91.5-1.21.2-1.0-1.3-1.0-1.01.11.5-1.51.5-1.51.5-1.51.71.71.81.7-1.8-1.81.4-2.3
Total sessions with >9 infusions2.32.64.81.70.7-1.21.4-1.71.4-1.7-1.6-1.7-1.71.71.3-1.61.3-1.31.3-1.61.81.81.81.8-1.8-1.81.6-2.2
Short access day 1 total inactive lever presses0.50.61.30.70.3-0.50.8-0.80.7-0.3-0.7-0.4-0.40.30.7-0.70.9-0.90.9-0.80.80.80.80.8-0.8-0.81.1-0.9
Short access day 10 total inactive lever presses1.41.62.91.70.9-1.31.2-0.31.3-0.7-0.3-0.8-0.80.81.1-1.61.3-1.31.3-1.51.51.51.61.5-1.6-1.50.7-1.7
Short access day 1 total infusions1.71.83.91.50.8-1.10.8-1.21.2-1.5-1.0-1.3-1.31.20.7-1.50.9-0.90.9-1.41.51.51.61.5-1.6-1.52.0-2.0
Short access day 10 total infusions0.40.41.50.90.0-0.40.4-0.60.6-0.7-0.4-0.7-0.70.70.3-0.70.4-0.40.4-0.70.80.80.90.8-0.9-0.80.4-1.2
Short access total infusions2.52.86.91.90.4-1.11.3-1.51.5-1.8-1.4-1.7-1.71.61.1-1.71.2-1.21.2-1.72.01.92.12.0-2.1-2.01.3-2.6
Short access day 1 locomotion4.14.37.22.61.3-1.81.2-1.72.0-2.6-1.6-2.6-2.62.61.0-2.21.2-1.21.2-2.22.32.32.42.4-2.4-2.41.9-2.7
Short access day 10 total locomotion1.01.11.71.21.1-1.10.9-1.31.0-1.2-1.1-1.2-1.21.20.9-1.01.0-1.01.0-1.00.90.90.91.0-0.9-0.91.1-0.7
Short access total locomotion4.44.66.72.61.8-2.21.8-1.92.2-2.6-1.9-2.5-2.52.61.6-2.31.8-1.81.8-2.22.22.22.32.2-2.3-2.22.0-2.1
One hour access (0.3 mA shock)0.20.20.5-0.4-0.40.5-0.50.4-0.60.60.50.60.6-0.7-0.40.4-0.40.4-0.40.5-0.4-0.4-0.4-0.40.40.30.4-0.1
Compulsive drug intake0.60.62.10.51.4-1.01.0-1.50.9-0.5-1.4-0.5-0.50.51.0-0.50.8-0.80.8-0.60.40.40.30.4-0.3-0.40.00.7
One hour access (shock baseline)0.20.20.8-0.1-0.90.6-0.50.2-0.50.40.50.40.4-0.5-0.30.3-0.30.3-0.30.3-0.1-0.00.0-0.0-0.0-0.00.8-0.9
Social response proportion0.30.30.60.50.6-0.60.50.40.5-0.70.0-0.6-0.60.80.6-0.60.6-0.60.6-0.50.40.40.40.4-0.5-0.40.5-0.2
Social responses0.70.91.3-1.0-0.40.7-1.11.1-1.10.90.91.11.1-1.0-0.90.9-0.90.9-0.91.0-1.1-1.0-1.0-1.01.01.01.10.6
Social time0.40.61.70.61.1-1.00.21.30.3-1.21.3-1.3-1.31.20.5-0.70.6-0.60.6-0.30.20.10.30.1-0.3-0.10.5-0.3
Soleus weight3.410.012.3-3.4-2.32.9-3.33.4-3.33.03.53.03.0-2.9-3.23.3-3.23.2-3.23.4-3.4-3.4-3.3-3.43.33.4-2.12.6
Bone: stiffness1.32.03.2-1.5-1.21.4-1.61.7-1.51.61.81.61.6-1.6-1.41.4-1.41.4-1.41.4-1.4-1.4-1.3-1.41.31.3-0.70.8
Tibialis anterior weight1.13.75.8-2.1-2.42.2-1.82.2-2.12.02.41.91.9-1.8-1.92.0-1.91.9-1.92.0-1.7-1.8-1.7-1.71.71.7-2.10.5
Time to tail flick, vehicle, before self-admin1.91.94.21.22.1-1.71.5-1.31.3-1.6-1.2-1.6-1.61.61.6-1.41.6-1.61.6-1.20.91.00.90.9-0.9-0.91.70.0
Time to tail flick, vehicle, after self-admin0.91.03.0-1.3-1.11.2-1.10.7-1.00.70.80.70.7-0.6-0.81.1-0.80.8-0.81.0-1.0-1.0-1.1-1.01.11.0-1.71.1
Time to tail flick, test, before self-admin0.30.32.60.11.1-0.50.3-0.50.10.4-0.70.40.4-0.30.4-0.00.4-0.40.40.0-0.3-0.2-0.3-0.20.30.21.60.8
Time to tail flick, test, after self-admin0.20.20.7-0.5-0.90.8-0.6-0.4-0.40.6-0.20.40.4-0.4-0.60.5-0.60.6-0.60.4-0.3-0.2-0.3-0.30.30.3-0.30.2
Delta time to tail flick, vehicle, before/after SA2.62.66.0-1.8-2.52.2-1.81.5-1.81.51.61.61.6-1.5-1.51.8-1.51.5-1.51.6-1.3-1.4-1.4-1.41.41.4-2.20.5
Delta time to tail flick, test, before/after SA0.30.21.6-0.1-1.30.7-0.3-0.6-0.0-0.2-0.2-0.4-0.40.3-0.30.1-0.30.3-0.3-0.10.40.30.30.3-0.3-0.3-1.2-0.6
Tibia length0.92.64.1-2.0-1.82.0-1.41.0-2.01.71.01.81.8-1.8-1.61.9-1.61.6-1.61.8-1.7-1.5-1.7-1.61.71.60.80.8
Ambulatory time before self-admin0.50.52.7-0.8-1.71.2-0.40.3-0.81.00.20.90.9-0.8-0.50.7-0.40.4-0.40.6-0.1-0.2-0.1-0.10.10.00.5-1.2
Ambulatory time after self-admin0.91.03.8-1.2-2.01.6-1.10.6-1.21.00.81.01.0-0.9-1.11.0-1.11.1-1.10.9-0.6-0.6-0.5-0.60.50.6-0.3-0.5
Bone: tissue strength4.54.45.8-2.2-1.72.0-2.12.0-2.02.32.12.42.4-2.4-2.12.1-2.12.1-2.12.1-2.1-2.1-2.1-2.12.12.1-2.01.8
Total heroin consumption3.64.26.02.01.1-1.72.3-2.42.0-2.0-1.9-2.1-2.12.02.1-2.02.2-2.22.2-2.12.22.22.22.2-2.2-2.20.8-2.2
Bone: trabecular number1.01.54.4-1.4-2.11.8-1.31.2-1.31.01.20.90.9-0.9-1.31.3-1.31.3-1.31.2-0.9-1.0-0.9-0.90.90.9-1.90.2
Bone: trabecular spacing1.72.16.01.72.4-2.01.5-1.41.5-1.4-1.4-1.3-1.31.31.5-1.61.5-1.51.5-1.41.01.11.11.1-1.1-1.12.2-0.1
Bone: trabecular thickness2.73.28.7-1.8-1.81.7-1.71.9-1.61.62.01.71.7-1.7-1.81.7-1.81.8-1.81.7-1.6-1.7-1.7-1.71.71.7-3.01.4
Bone: trabecular tissue density0.10.11.10.20.8-0.60.3-0.10.2-0.10.10.10.1-0.00.4-0.30.4-0.40.4-0.20.00.10.10.1-0.1-0.11.00.1
Water consumed over 24 hours0.40.41.9-0.6-0.50.5-0.60.2-0.40.60.40.60.6-0.6-0.70.6-0.70.7-0.70.6-0.6-0.6-0.6-0.60.60.6-1.40.8
Number of responses in last shaping day0.70.72.5-0.8-1.11.0-1.30.5-0.90.60.50.50.5-0.5-1.60.8-1.41.4-1.40.7-0.6-0.5-0.5-0.50.50.50.2-0.2