Hub : Genes

Ace

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Ace 0.46 0.15 7.0e-07 0.26 0.27 0.22 0.24 7.5e-07 5.0e-07 5.1e-06 1.7e-06
2 BLA gene expression Ace 0.17 0.08 6.3e-10 0.13 0.17 0.18 0.18 1.8e-07 1.5e-09 4.9e-10 5.3e-10
3 Liver gene expression Ace 0.08 0.04 3.7e-11 0.06 0.08 0.07 0.07 7.1e-07 4.6e-09 9.7e-09 2.7e-08
4 PL gene expression Ace 0.16 0.05 0.0e+00 0.29 0.28 0.28 0.29 1.2e-31 5.2e-30 3.0e-31 7.5e-32
5 Brain gene expression Ace 0.1 0.04 4.3e-10 0.1 0.07 0.09 0.1 7.2e-10 2.3e-07 2.3e-08 3.2e-09
6 IC gene expression Ace 0.41 0.11 0.0e+00 0.34 0.35 0.35 0.24 3.8e-15 1.2e-15 1.5e-15 1.2e-10
7 pVTA gene expression Ace 0.15 0.06 1.3e-14 0.18 0.18 0.18 0.2 1.6e-14 1.1e-14 4.4e-14 8.8e-16
8 NAcc gene expression Ace 0.11 0.04 1.7e-16 0.1 0.11 0.11 0.11 2.4e-14 1.2e-16 2.4e-16 2.3e-16
9 Adipose gene expression Ace 0.1 0.04 3.5e-10 0.08 0.07 0.08 0.09 4.9e-09 9.6e-09 2.6e-09 9.6e-10
10 pVTA mRNA stability Ace 0.05 0.03 9.1e-04 0.01 0.03 0.03 0.03 2.6e-02 1.3e-03 1.2e-03 2.0e-03
11 Adipose mRNA stability Ace 0.19 0.07 7.6e-15 0.14 0.11 0.11 0.13 6.7e-15 1.3e-12 3.0e-12 2.2e-14
12 NAcc mRNA stability Ace 0.06 0.03 4.5e-05 0.03 0.02 0.03 0.02 2.5e-05 7.3e-04 1.0e-04 1.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density2.23.710.6-1.8-0.0-1.1-1.8-1.7-2.0-0.9-3.03.31.12.12.0
Area under the delay curve0.20.30.9-0.6-0.3-0.4-0.7-0.3-0.9-0.3-0.80.6-0.1-0.1-0.1
BMI with tail1.13.88.7-1.4-3.0-1.9-1.6-0.7-1.9-2.60.1-1.4-2.3-2.2-2.4
BMI without tail2.26.613.3-2.6-3.6-2.9-3.0-1.7-3.2-3.4-1.2-0.1-2.6-2.0-2.0
Body weight2.812.125.8-4.1-5.1-4.3-4.3-3.1-4.5-4.6-2.60.8-2.4-1.0-1.1
Weight adjusted by age0.40.62.10.80.50.70.70.60.70.71.0-1.40.1-0.3-0.6
Bone surface5.710.318.5-3.8-2.5-3.1-3.5-3.6-3.6-2.5-4.33.50.73.02.9
Bone volume4.88.616.6-3.5-2.0-2.8-3.3-3.2-3.4-2.3-4.13.60.52.52.4
Breakpoint value in progressive ratio session0.20.20.8-0.1-0.4-0.3-0.0-0.70.3-0.5-0.10.50.10.70.9
Number of licking bursts0.00.00.2-0.1-0.2-0.10.10.10.0-0.1-0.0-0.10.20.40.3
Context. condit. distance diff. score0.81.02.70.8-0.10.40.70.60.90.21.5-1.6-0.7-1.2-1.4
Locomotion velocity, session 11.61.73.5-1.6-0.7-1.1-1.7-1.1-1.5-0.5-1.91.70.61.21.3
Locomotion distance, session 10.20.30.7-0.60.2-0.2-0.6-0.0-0.70.3-0.90.80.60.50.4
Locomotion velocity, session 20.70.82.1-0.8-0.2-0.6-0.7-0.9-0.1-0.1-1.01.30.21.51.4
Locomotion distance, session 20.10.10.40.00.40.20.20.20.40.6-0.00.40.30.40.1
Locomotion velocity, session 30.20.20.70.20.40.40.20.00.30.6-0.00.10.80.90.6
Locomotion distance, session 30.30.31.6-0.3-0.2-0.1-0.0-0.5-0.10.1-0.50.40.71.20.9
Stereotopy head waving bouts, day 30.40.41.40.31.20.60.20.20.00.6-0.40.91.10.40.6
Stereotopy head waving duration, day 30.20.31.00.51.00.70.50.60.30.50.30.10.3-0.5-0.3
Locomotion velocity, session 70.30.30.90.70.90.70.70.20.60.80.30.00.70.40.1
Locomotion distance, session 70.10.20.50.50.30.30.70.30.40.40.5-0.3-0.2-0.2-0.6
Stereotopy head waving bouts, day 70.60.71.70.51.10.80.60.40.71.0-0.10.41.31.01.1
Stereotopy head waving duration, day 71.21.53.71.11.91.51.21.11.51.60.50.31.30.70.9
Locomotion velocity, session 80.50.61.6-0.6-1.3-0.7-0.70.1-0.1-0.80.4-0.8-1.1-0.7-0.9
Locomotion distance, session 80.30.51.80.3-0.00.10.30.30.60.10.8-0.5-1.0-1.0-1.3
Degree of sensitization distance0.50.62.20.1-0.2-0.10.00.6-0.1-0.10.6-0.6-1.1-1.5-1.5
Degree of sensitization stereotypy0.91.01.70.91.21.11.00.71.31.30.5-0.21.31.01.0
Conditioned locomotion0.40.51.6-0.3-0.4-0.5-0.2-0.6-0.3-0.9-0.10.7-1.3-1.0-1.0
Cocaine response after cond. corrected0.30.41.60.2-0.10.20.50.0-0.10.60.1-1.01.01.30.8
Cocaine response after cond. not corrected1.21.46.90.10.10.30.5-0.40.20.9-0.3-0.62.02.62.1
Cocaine response before conditioning0.70.93.1-0.10.50.1-0.2-0.70.20.4-0.71.01.41.81.7
Saline control response1.31.86.5-0.8-1.6-1.4-0.9-1.0-0.6-1.8-0.10.2-2.5-1.5-1.3
Bone: connectivity density2.64.010.3-2.1-0.6-1.5-1.9-2.1-2.0-1.1-3.03.20.82.11.9
Bone: cortical apparent density2.63.69.02.33.02.62.12.21.72.41.3-0.11.4-0.7-0.8
Bone: cortical area2.03.15.6-1.9-1.3-1.4-1.9-1.8-2.2-1.1-2.41.60.92.01.9
Bone: cortical porosity9.310.116.7-3.3-3.4-3.3-3.0-4.1-2.8-2.5-3.41.80.94.04.1
Bone: cortical porosity7.27.812.3-3.0-3.2-2.9-2.7-3.5-2.7-2.5-3.01.30.83.23.3
Bone: cortical thickness2.74.512.61.93.02.71.71.91.12.80.3-0.03.61.91.8
Bone: cortical thickness2.42.96.21.62.42.01.51.31.32.10.30.12.51.71.7
Bone: cortical tissue density2.63.58.82.33.02.62.02.11.72.31.3-0.01.3-0.7-0.8
Condit. Reinf. active minus inactive responses2.02.34.3-1.7-1.6-1.9-1.6-2.1-1.5-1.8-1.61.3-0.90.60.7
Condit. Reinf. active-inactive response ratio0.70.72.2-0.9-0.9-1.1-0.7-1.5-0.7-1.0-0.90.6-0.20.60.6
Condit. Reinf. active responses2.63.34.9-2.1-1.8-2.2-2.0-2.2-1.8-2.2-1.91.9-1.60.20.2
Condit. Reinf. inactive responses1.21.52.5-1.5-0.9-1.3-1.5-1.0-1.4-1.3-1.31.6-1.3-0.4-0.5
Incentive salience index mean2.42.95.0-1.9-1.4-1.9-1.7-2.2-1.6-1.7-2.12.1-0.41.21.3
Condit. Reinf. lever presses0.81.24.6-1.1-0.4-0.8-1.0-1.0-0.6-0.8-1.52.10.11.20.9
Condit. Reinf. active minus inactive responses5.97.612.6-3.3-2.4-3.0-2.9-3.5-2.9-2.5-3.53.0-0.72.12.1
Condit. Reinf. active-inactive response ratio4.45.18.7-2.6-1.7-2.3-2.3-2.8-2.1-1.8-2.92.5-0.12.32.3
Condit. Reinf. active responses5.78.013.5-3.4-2.7-3.3-3.1-3.7-3.0-3.0-3.33.0-1.61.11.2
Condit. Reinf. inactive responses1.62.04.0-1.4-1.2-1.6-1.4-1.6-1.4-1.7-1.21.5-2.0-1.0-0.7
Condit. Reinf. lever presses1.82.54.3-1.8-1.6-1.8-1.7-2.1-1.5-1.5-1.91.7-0.91.01.0
Condit. Reinf. lever reinforcers received5.37.312.5-3.2-2.5-3.1-2.9-3.5-2.9-2.8-3.22.9-1.41.21.3
Conditioned reinforcement - actives0.50.91.9-0.8-1.2-1.0-1.0-0.9-0.9-0.8-0.1-0.2-1.1-1.4-1.0
Conditioned reinforcement - inactives0.71.12.5-1.2-1.6-1.3-1.3-1.4-1.3-1.1-0.80.2-0.5-0.00.1
Conditioned locomotion2.53.26.2-2.0-2.3-2.2-2.2-2.5-2.1-2.0-1.60.9-1.2-0.40.1
Patch foraging indifference point 0 sec2.75.07.2-2.5-2.1-2.6-2.5-2.4-2.6-2.7-2.32.3-2.4-0.7-0.8
Patch foraging indifference point AUC0.60.81.2-0.9-1.1-1.0-1.1-0.7-0.9-1.1-0.30.2-0.9-1.0-1.0
Delay disc. indifference point, 0s delay0.20.30.80.50.90.70.60.50.40.40.20.30.3-0.2-0.4
Delay disc. indifference point, 16s delay0.80.82.1-1.1-1.2-1.0-1.1-0.8-1.5-0.9-1.00.5-0.5-0.3-0.2
Delay disc. indifference point, 2s delay0.80.93.0-1.20.2-0.6-1.2-0.5-1.3-0.4-1.51.7-0.10.30.1
Delay disc. indifference point, 24s delay1.61.83.8-1.6-1.7-1.5-1.6-0.9-2.0-1.4-1.10.6-1.2-0.9-1.0
Delay disc. indifference point, 4s delay0.60.61.90.40.70.60.30.10.20.9-0.1-0.21.41.41.3
Delay disc. indifference point, 8s delay0.10.20.6-0.20.40.2-0.30.0-0.60.2-0.70.80.50.10.1
Indifference point function ln k0.30.51.50.10.90.40.30.1-0.10.4-0.61.00.61.21.0
Indifference point function log k0.30.51.50.10.90.40.30.1-0.10.4-0.61.00.61.21.0
Patch foraging total patch changes 0 sec2.95.47.8-2.7-2.3-2.7-2.6-2.6-2.8-2.8-2.42.2-2.2-0.5-0.6
Patch foraging total patch changes 12 sec3.34.27.3-2.2-2.0-2.4-2.3-1.8-1.9-2.5-1.51.7-2.7-1.6-1.6
Patch foraging total patch changes 18 sec1.72.55.0-1.8-2.2-2.1-1.7-1.6-1.7-2.1-1.20.8-1.6-0.3-0.3
Patch foraging total patch changes 24 sec2.33.95.9-2.4-1.9-2.2-2.3-2.3-2.4-2.1-2.32.1-1.2-0.20.1
Patch foraging total patch changes 6 sec1.92.84.2-2.0-1.9-2.0-2.0-2.0-2.0-1.9-1.71.4-1.4-0.00.0
Patch foraging time to switch 0 sec0.30.50.90.70.70.70.70.80.90.90.4-0.50.60.71.0
Patch foraging water rate 0 sec1.32.74.8-1.9-1.8-1.9-2.0-1.7-2.2-2.0-1.71.4-1.1-0.2-0.5
Patch foraging water rate 12 sec0.51.03.50.60.50.90.60.70.21.10.1-0.91.91.61.4
Patch foraging water rate 18 sec0.50.82.8-0.40.50.1-0.3-0.4-0.40.3-1.11.11.11.71.4
Patch foraging water rate 24 sec0.10.10.7-0.1-0.10.10.10.10.00.3-0.1-0.30.50.80.6
Patch foraging water rate 6 sec0.50.71.6-0.60.1-0.2-0.5-0.7-1.0-0.2-1.31.21.01.11.2
Seeking ratio, delayed vs. immediate footshock0.40.51.20.3-0.30.10.20.60.3-0.40.9-1.1-0.7-1.0-1.1
Distance traveled before self-admin0.60.72.80.30.10.40.7-0.00.30.60.0-0.81.51.71.5
Distance traveled after self-admin0.30.41.30.3-0.40.10.6-0.40.60.30.5-1.10.71.00.6
Extensor digitorum longus weight2.911.324.73.00.82.22.74.12.30.84.4-4.2-2.1-4.9-5.0
Bone: elastic displacement1.41.64.91.11.41.41.00.90.91.60.4-0.52.21.21.4
Bone: elastic work0.60.82.3-0.5-0.1-0.1-0.6-0.6-0.70.1-1.10.71.51.31.5
Bone: endosteal estimation11.124.340.5-5.9-6.4-6.3-5.6-6.3-5.2-5.6-4.83.2-2.81.71.6
Bone: endosteal perimeter12.326.147.6-6.3-6.9-6.6-5.9-6.1-5.6-6.1-4.72.5-3.21.21.1
Epididymis fat weight0.31.11.9-1.1-1.4-1.2-1.2-0.7-1.3-1.2-0.50.1-1.4-0.9-1.0
Delta time in closed arm before/after self-admin0.50.51.90.20.50.40.20.10.20.6-0.20.11.41.21.0
Delta time in open arm before/after self-admin1.51.56.40.40.20.10.20.50.3-0.20.90.0-2.1-2.5-2.5
Diff in mean of infusions in LGA sessions1.62.04.11.81.41.71.62.01.81.41.6-0.60.2-0.6-0.6
Delay discount exponential model param0.30.41.10.80.50.50.90.41.00.40.8-0.60.20.10.2
Extinction: sum of active levers before priming0.40.51.80.3-0.1-0.00.30.00.3-0.30.70.0-1.2-1.2-1.3
Active lever presses in extinction session 61.31.32.5-1.2-1.6-1.4-1.2-1.6-1.1-1.6-1.00.6-0.90.40.2
Bone: final force1.42.24.6-1.5-0.8-0.9-1.4-1.6-1.6-0.4-2.01.11.52.21.9
Bone: final moment1.62.65.7-1.5-0.8-0.9-1.4-1.7-1.6-0.4-2.11.31.72.42.2
Food consumed during 24 hour testing period2.53.56.6-1.9-2.6-2.1-2.2-1.2-1.8-2.4-0.80.5-2.5-1.5-1.7
Glucose1.01.64.31.30.71.21.51.51.21.31.5-2.10.90.10.1
Heart weight0.20.31.40.1-0.50.20.30.5-0.40.20.4-1.20.8-0.1-0.0
Delay discount hyperbolic model param0.30.41.10.80.40.50.90.41.10.40.9-0.70.1-0.00.1
Intermittent access intake day 1-15 change0.20.31.70.3-0.5-0.10.20.20.4-0.20.8-1.3-0.8-0.1-0.6
Intermittent access intake escalation0.20.51.5-0.2-1.1-0.6-0.3-0.2-0.1-0.80.5-1.2-1.2-0.1-0.6
Intermittent access intake escalation 20.40.51.5-0.3-1.2-0.7-0.4-0.5-0.2-0.90.3-0.9-1.1-0.0-0.5
Intermitt. access day 1 inactive lever presses0.93.65.4-2.1-1.8-2.2-2.3-2.2-2.0-2.1-2.22.0-1.40.80.3
Intermitt. access day 15 inactive lever presses1.22.43.6-1.5-1.2-1.6-1.9-1.9-1.8-1.8-1.91.8-1.20.50.2
Intermitt. access escalation Index1.82.54.51.81.31.72.11.71.91.51.8-2.01.50.30.4
Intermittent access day 1 total infusions0.60.91.7-1.3-1.1-1.2-1.2-1.2-1.2-1.0-1.00.7-0.4-0.00.1
Intermittent access day 15 total infusions1.52.25.1-1.4-2.3-1.7-1.5-1.3-1.4-1.8-0.3-0.6-1.8-1.2-1.2
Intermittent access terminal intake (last 3 days)2.43.26.6-1.9-2.6-2.2-2.0-1.9-1.8-2.2-0.80.1-2.1-1.2-1.1
Intermittent access total infusions2.32.74.9-1.9-2.2-2.0-1.9-1.7-1.7-2.0-1.00.4-1.7-1.2-1.0
Intermittent access day 1 locomotion3.03.96.6-2.4-2.6-2.4-2.5-2.6-2.3-2.1-1.91.0-0.60.10.7
Intermittent access day 15 total locomotion2.74.89.7-2.6-3.1-2.8-2.8-2.2-2.3-2.8-1.40.5-2.0-1.2-0.8
Intermittent access total locomotion5.66.711.3-3.2-3.3-3.3-3.4-3.0-2.9-3.0-2.31.5-1.8-0.5-0.2
Intermittent access standard deviation0.30.71.2-0.9-1.1-0.9-1.1-0.9-0.7-1.0-0.50.5-0.9-0.4-0.6
Left kidney weight0.10.73.2-0.10.40.40.20.1-0.20.7-0.50.11.81.31.4
Right kidney weight0.20.73.3-0.7-0.1-0.1-0.6-0.3-0.80.3-0.90.11.81.21.3
Cocaine induced anxiety0.60.94.00.40.70.60.60.00.20.9-0.20.12.01.41.7
Post-drug Anxiety0.70.83.30.50.70.80.60.40.30.90.1-0.41.81.11.4
Baseline Anxiety0.10.10.40.40.10.30.20.50.20.00.5-0.7-0.2-0.5-0.4
Tail length2.49.415.5-3.7-3.0-3.4-3.9-3.6-3.6-3.0-3.73.2-0.81.41.3
Length with tail1.77.613.6-3.7-3.3-3.3-3.7-2.8-3.4-2.9-3.02.1-0.70.50.7
Length without tail0.20.51.1-1.1-1.1-0.8-1.0-0.3-1.0-0.8-0.60.2-0.1-0.3-0.2
Times rat made contact with spout0.60.72.4-1.0-1.5-1.0-1.0-0.7-0.8-1.0-0.70.4-0.20.20.4
Lifetime Intake2.63.15.0-2.1-2.2-2.2-2.1-1.8-2.0-2.1-1.30.7-1.8-1.0-0.9
Liver weight, left3.55.89.1-3.0-2.6-2.7-2.9-2.8-2.2-2.3-2.72.1-0.12.12.0
Liver weight, right1.11.97.50.31.20.90.20.50.11.4-0.80.72.72.32.0
Locomotor activity0.30.41.0-0.7-1.0-0.9-0.6-1.0-0.3-0.5-0.20.1-0.8-0.2-0.2
Locomotor testing distance0.61.02.8-1.0-1.6-1.4-1.0-1.7-0.7-1.0-0.5-0.0-1.1-0.10.0
Locomotor testing rearing0.40.82.9-0.4-1.7-1.2-0.5-1.50.1-1.00.2-0.5-1.3-0.20.0
Locomotion in novel chamber0.91.14.4-0.1-0.20.10.1-0.10.10.8-0.1-1.01.91.92.1
Locomotion in novel chamber post-restriction0.81.42.7-1.6-1.3-1.4-1.2-1.3-1.6-1.3-1.30.8-0.4-0.10.1
Fecal boli incidents, locomotor time 10.10.10.5-0.0-0.7-0.30.0-0.5-0.1-0.20.3-0.6-0.3-0.2-0.2
Change in fecal boli incidents, locomotor task0.10.10.60.10.20.20.10.5-0.20.00.2-0.0-0.3-0.8-0.7
Time >=10cm from walls, locomotor time 12.52.64.21.81.21.72.01.52.01.81.8-1.91.30.80.5
Bouts of movement, locomotor time 10.20.20.50.60.70.70.40.40.30.70.30.10.4-0.4-0.6
Total resting periods, locomotor time 10.20.30.60.60.70.70.30.50.20.80.20.20.6-0.3-0.5
Rest time, locomotor task time 10.10.20.50.20.70.30.30.10.10.5-0.30.70.50.50.1
Distance moved, locomotor task time 10.20.30.6-0.6-0.7-0.6-0.80.1-0.6-0.8-0.3-0.1-0.5-0.30.0
Vertical activity count, locomotor time 10.10.40.6-0.7-0.6-0.6-0.8-0.6-0.7-0.6-0.60.1-0.20.50.8
Time >=10cm from walls, locomotor time 20.50.73.70.40.00.30.4-0.20.60.30.1-0.51.11.91.6
Bouts of movement, locomotor time 20.10.20.40.70.60.60.50.60.40.20.5-0.3-0.0-0.1-0.5
Total resting periods, locomotor time 20.20.40.80.90.90.80.80.80.60.50.6-0.50.3-0.0-0.4
Rest time, locomotor task time 22.32.94.92.12.12.12.22.01.81.71.8-1.41.0-0.6-0.7
Distance moved, locomotor task time 20.50.61.5-0.7-0.7-0.6-0.9-0.4-0.4-0.6-0.80.80.11.21.2
Vertical activity count, locomotor time 21.82.43.5-1.7-1.4-1.7-1.8-1.9-1.4-1.5-1.81.9-0.81.31.2
Light reinforcement 10.61.43.7-0.70.2-0.5-0.8-0.3-1.1-1.1-1.01.9-1.9-1.3-1.6
Light reinforcement 20.91.34.9-1.00.3-0.6-1.2-1.0-1.4-0.9-1.62.2-1.0-0.4-0.7
Bone: marrow area10.723.439.3-5.8-6.3-6.1-5.5-6.3-5.1-5.5-4.83.1-2.71.81.7
Bone: maximum diameter4.68.613.5-3.7-3.1-3.3-3.4-3.4-3.5-2.8-3.52.2-0.51.91.9
Bone: maximum force1.73.15.9-2.2-1.6-1.6-2.0-1.7-2.4-1.2-2.31.20.81.61.5
Bone: maximum moment2.03.46.1-2.2-1.6-1.6-2.1-1.9-2.5-1.1-2.51.51.01.81.8
Mean time between licks in bursts0.20.51.6-0.4-1.1-0.5-0.3-0.3-0.7-0.40.4-1.2-0.5-0.9-0.7
Mean num. licks in bursts0.20.30.6-0.5-0.8-0.5-0.7-0.3-0.6-0.6-0.20.3-0.6-0.7-0.4
Cd content in liver4.44.98.32.62.02.32.62.42.61.92.9-2.30.3-1.9-1.7
Co content in liver1.82.03.61.61.21.41.41.71.81.01.9-1.4-0.1-1.5-1.3
Cu content in liver0.40.51.5-0.8-0.1-0.7-0.8-0.7-0.7-0.8-1.01.2-0.7-0.10.0
Fe content in liver0.20.20.80.10.40.20.2-0.30.60.5-0.20.50.40.70.9
K content in liver0.40.41.8-0.80.0-0.5-0.7-0.5-0.4-0.4-0.91.4-0.7-0.0-0.1
Mg content in liver0.80.82.90.61.70.90.61.00.80.60.11.3-0.6-0.9-1.0
Mn content in liver0.80.94.7-0.21.50.50.0-0.10.10.8-1.12.20.70.90.8
Na content in liver0.40.41.5-0.70.1-0.6-0.5-0.5-0.1-0.7-0.71.2-0.80.00.1
Rb content in liver2.83.37.22.02.72.32.02.22.22.41.3-0.41.30.20.2
Se content in liver0.91.12.11.11.21.21.31.51.10.91.1-0.70.1-1.1-0.9
Sr content in liver0.80.71.1-1.0-0.9-0.9-1.0-1.1-1.0-1.0-0.80.3-0.10.40.3
Zn content in liver0.30.40.90.51.00.70.70.70.50.70.3-0.30.70.20.5
Bone: minimum diameter11.020.032.8-5.5-5.7-5.5-5.3-5.3-5.3-5.1-4.52.9-2.21.21.2
Time in familiar zone, hab. session 10.90.92.7-0.4-1.2-0.8-0.30.1-0.3-1.00.4-0.5-1.6-1.3-1.5
Time in novel zone, hab. session 11.11.13.00.81.31.10.60.30.51.2-0.10.01.71.41.5
Total zone transitions, hab. session 10.10.10.4-0.4-0.6-0.3-0.40.1-0.4-0.1-0.0-0.1-0.1-0.3-0.5
Total locomotion distance, hab. session 10.91.32.7-1.3-0.6-0.9-1.4-0.9-1.4-0.5-1.61.60.61.20.8
Locomotion velocity, hab. session 11.11.52.9-1.6-0.9-1.2-1.6-1.1-1.6-0.8-1.71.60.30.90.6
Time in familiar zone, hab. session 20.80.92.4-0.5-1.6-1.0-0.4-0.4-0.0-0.90.5-0.9-1.5-1.1-1.1
Time in novel zone, hab. session 21.31.33.60.31.70.90.30.3-0.21.0-0.91.11.91.61.5
Total zone transitions, hab. session 20.20.21.0-0.1-0.2-0.1-0.10.50.20.10.4-0.1-0.5-0.7-1.0
Total locomotion distance, hab. session 20.40.51.6-0.6-0.0-0.4-0.80.1-0.7-0.3-0.61.3-0.8-0.8-1.1
Locomotion velocity, hab. session 20.40.51.4-0.6-0.0-0.4-0.80.2-0.7-0.3-0.51.2-0.7-0.8-1.2
Novel to familiar place preference ratio0.40.40.9-0.8-0.7-0.7-0.8-0.9-0.9-0.7-0.70.40.10.30.6
Novelty place preference0.20.20.5-0.5-0.4-0.4-0.5-0.6-0.6-0.4-0.60.30.20.40.7
Time in novel zone, NPP test0.20.30.9-0.4-0.3-0.3-0.4-0.7-0.5-0.2-0.50.20.50.61.0
Total zone transitions, NPP test0.10.20.6-0.40.3-0.0-0.50.5-0.30.3-0.40.8-0.0-0.2-0.6
Total locomotion distance, NPP test0.60.93.2-1.1-0.2-0.7-1.2-0.5-1.1-0.2-1.41.80.20.60.2
Locomotion velocity, NPP test0.40.61.9-0.9-0.2-0.6-1.1-0.1-1.1-0.4-1.01.4-0.5-0.3-0.7
Intraocular pressure0.91.22.7-0.8-1.6-1.2-0.9-0.8-1.5-1.2-0.2-0.7-1.3-1.3-1.0
Delta distance traveled before/after self-admin0.20.20.60.60.10.40.50.20.80.10.8-0.4-0.2-0.3-0.5
Delta ambulatory time before/after self-admin0.10.10.40.2-0.2-0.00.1-0.20.2-0.20.4-0.1-0.3-0.6-0.7
Parametrial fat weight0.71.53.3-1.3-0.3-0.7-1.2-1.1-1.4-0.5-1.81.61.01.61.4
Pavlov. Cond. lever latency2.22.74.51.91.41.61.81.81.51.32.1-2.1-0.3-1.7-1.4
Pavlov. Cond. magazine entry latency3.95.09.4-2.7-1.7-2.3-2.6-2.4-2.2-2.2-2.93.1-0.41.51.2
Pavlov. Cond. change in total contacts3.43.67.9-2.2-1.3-1.9-2.1-2.2-1.8-1.8-2.52.8-0.41.41.2
Pavlov. Cond. index score3.44.37.7-2.5-1.7-2.2-2.4-2.2-2.0-2.0-2.72.8-0.31.61.2
Pavlov. Cond. latency score2.73.45.7-2.2-1.6-1.9-2.1-2.0-1.8-1.8-2.32.4-0.31.41.1
Pavlov. Cond. lever contacts2.63.15.1-2.0-1.5-1.8-1.9-2.0-1.6-1.5-2.22.30.11.71.4
Pavlov. Cond. magazine entry number3.03.88.72.21.21.92.22.21.91.82.6-3.00.4-1.3-1.1
Pavlov. Cond. intertrial magazine entries1.31.65.4-0.8-1.1-1.1-0.8-0.5-1.0-1.2-0.0-0.1-2.3-2.1-1.7
Pavlov. Cond. lever-magazine prob. diff.3.74.68.2-2.6-1.7-2.2-2.4-2.3-2.2-2.0-2.82.9-0.21.81.5
Pavlov. Cond. response bias5.97.315.3-3.1-1.6-2.5-2.9-3.1-2.6-2.1-3.73.90.22.52.2
Pavlov. Cond. lever latency0.30.51.00.80.70.80.71.00.60.60.8-0.50.4-0.5-0.5
Pavlov. Cond. magazine entry latency2.02.54.21.81.21.71.91.61.91.81.9-2.01.0-0.1-0.1
Pavlov. Cond. change in total contacts0.20.41.4-0.6-0.7-0.8-0.4-0.7-0.0-0.7-0.10.2-1.2-0.6-0.4
Pavlov. Cond. index score0.10.10.2-0.0-0.2-0.10.2-0.20.30.10.2-0.50.10.40.5
Pavlov. Cond. latency score0.10.20.70.1-0.10.10.4-0.20.50.40.2-0.60.40.70.8
Pavlov. Cond. lever contacts0.20.30.5-0.7-0.5-0.6-0.6-0.7-0.5-0.5-0.60.5-0.60.30.2
Pavlov. Cond. magazine entry number2.83.45.3-2.1-1.7-2.1-2.3-1.7-2.3-2.3-1.92.0-1.6-0.3-0.4
Pavlov. Cond. intertrial magazine entries10.215.323.3-4.6-4.2-4.6-4.8-4.0-4.8-4.8-4.03.5-3.2-0.3-0.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.1-0.10.10.3-0.20.40.30.3-0.60.20.40.5
Pavlov. Cond. response bias0.00.00.1-0.1-0.1-0.10.0-0.30.1-0.0-0.0-0.1-0.20.10.2
Time in closed arm before self-admin0.10.10.40.20.10.20.10.20.3-0.10.1-0.20.30.50.6
Time in closed arm after self-admin0.90.92.10.90.60.90.90.81.10.80.8-1.11.50.81.1
Time in open arm before self-admin1.31.44.40.80.60.91.00.60.71.30.6-1.52.11.61.5
Time in open arm after self-admin0.50.62.1-0.2-0.5-0.4-0.2-0.1-0.3-0.40.4-0.5-1.3-1.4-1.4
Bone: periosteal estimation8.417.828.3-5.1-4.8-4.9-4.8-5.3-4.8-4.3-4.83.3-1.22.52.3
Bone: periosteal perimeter5.08.513.0-3.6-3.5-3.4-3.3-3.6-3.4-2.9-3.21.6-0.22.22.0
Bone: post-yield work1.31.95.2-1.6-2.3-1.7-1.3-1.7-1.5-1.4-1.10.1-0.10.90.9
Progressive ratio test 1 active lever presses2.53.15.2-2.1-2.0-2.1-2.1-2.3-2.2-1.9-1.71.1-1.3-0.2-0.0
Progressive ratio test 1 breakpoint2.93.65.5-2.3-2.1-2.2-2.3-2.3-2.3-2.1-1.91.3-1.5-0.3-0.2
Progressive ratio test 1 inactive lever presses2.63.75.6-2.3-2.3-2.4-2.3-2.3-2.2-2.1-1.91.4-1.6-0.1-0.1
Progressive ratio test 2 active lever presses5.16.09.3-2.9-3.0-3.0-2.9-3.0-3.0-2.8-2.31.3-1.9-0.4-0.2
Progressive ratio test 2 breakpoint5.66.49.9-3.0-3.1-3.1-3.0-3.1-3.1-2.9-2.31.2-2.0-0.4-0.2
Progressive ratio test 2 inactive lever presses2.33.76.0-2.2-2.1-2.2-2.4-1.8-2.4-2.3-1.71.2-1.8-1.1-1.0
Incentive Sensitization - Responses2.53.66.7-2.3-2.6-2.4-2.2-2.2-2.3-2.3-1.60.5-1.4-0.2-0.0
Incentive Sensitization - Breakpoint2.73.57.0-2.3-2.6-2.4-2.2-2.2-2.2-2.3-1.50.4-1.4-0.2-0.0
Sum of active levers in priming session hrs 5-61.00.91.81.10.50.71.10.91.10.51.3-0.6-0.8-1.0-1.1
Progressive ratio0.10.10.5-0.4-0.5-0.3-0.30.0-0.4-0.4-0.0-0.0-0.7-0.5-0.3
Food seeking constrained by brief footshock1.82.35.4-1.6-2.3-2.0-1.6-1.5-1.0-2.1-0.60.4-1.8-0.8-0.8
Seeking ratio, punishment vs. effort0.60.81.6-1.0-1.2-1.3-1.0-1.2-0.7-1.2-0.70.5-0.60.1-0.1
Retroperitoneal fat weight0.41.73.3-1.6-1.3-1.5-1.8-1.1-1.8-1.5-1.51.4-0.5-0.1-0.3
Reaction time number correct0.10.30.70.40.40.60.60.70.10.60.3-0.60.80.30.1
Reaction time mean minus median0.10.30.60.70.70.60.70.50.50.60.4-0.30.50.10.1
Reaction time mean minus median AUC0.51.32.81.31.71.41.41.41.11.50.8-0.51.1-0.00.1
Reaction time num false alarms2.63.76.4-2.5-2.5-2.4-2.3-2.1-2.1-2.4-1.81.1-1.20.50.4
Reaction time num false alarms AUC2.84.47.1-2.7-2.5-2.5-2.5-2.3-2.3-2.6-2.21.7-1.20.50.4
Reaction time trials correct on left0.10.30.70.40.40.60.60.70.10.60.3-0.60.80.30.1
Reaction time trials on left0.10.20.80.30.40.60.60.7-0.00.60.2-0.50.90.30.2
Reaction time mean0.81.33.21.21.81.31.30.91.21.50.40.21.11.00.9
Reaction time mean AUC1.11.84.11.52.01.51.61.11.61.70.70.11.11.00.8
Median of all reaction times1.01.43.51.21.91.31.30.81.31.60.30.31.11.21.0
Reaction time omissions0.50.82.0-0.60.3-0.3-0.5-0.7-1.0-0.0-1.41.40.51.11.2
Reaction time false alarm rate2.73.75.8-2.4-2.3-2.4-2.4-2.2-1.9-2.4-1.91.5-1.30.50.5
Reaction time premature initiation rate0.71.01.9-1.0-1.1-1.1-1.1-1.2-1.3-1.4-0.90.7-0.8-0.8-0.3
Reaction time premature initiations0.40.61.5-0.8-0.9-0.8-0.8-0.7-1.2-1.1-0.70.4-0.4-0.8-0.4
Std. dev. reaction times0.30.61.70.81.30.90.90.70.71.00.20.20.80.50.5
Reaction time trials completed0.10.20.80.30.40.60.60.7-0.00.60.2-0.50.90.30.2
Reaction time trials AUC0.10.30.70.40.40.60.60.80.10.60.3-0.60.80.20.1
Run reversals in cocaine runway, females0.10.10.40.20.20.3-0.10.5-0.30.2-0.0-0.50.50.6-0.1
Run reversals in cocaine runway, males0.20.20.90.10.00.10.20.0-0.10.0-0.0-0.70.90.90.8
Latency to leave start box in cocaine runway0.10.20.30.50.40.50.50.20.40.30.3-0.40.50.30.4
Latency to leave start box in cocaine runway, F0.70.82.50.60.40.60.70.20.40.70.3-0.91.61.41.5
Latency to leave start box in cocaine runway, M0.30.31.10.20.1-0.00.0-0.10.3-0.40.20.4-1.0-1.0-1.0
Std. dev. time between licks in bursts0.10.20.70.20.20.10.20.20.00.00.4-0.3-0.5-0.7-0.9
Total sessions with >9 infusions0.30.40.9-0.5-0.8-0.6-0.5-0.4-0.6-0.60.0-0.4-0.8-1.0-0.7
Short access day 1 total inactive lever presses1.92.54.3-2.0-1.7-1.8-2.0-1.6-2.1-1.7-1.91.1-0.10.91.0
Short access day 10 total inactive lever presses0.20.40.7-0.4-0.2-0.4-0.7-0.3-0.8-0.7-0.70.8-0.8-0.2-0.8
Short access day 1 total infusions0.40.51.4-0.8-0.6-0.8-0.8-0.4-0.9-0.8-0.60.4-1.2-0.5-0.5
Short access day 10 total infusions2.22.94.6-2.0-2.1-2.1-2.1-1.8-1.9-2.1-1.40.9-1.6-0.4-0.6
Short access total infusions1.21.52.3-1.5-1.4-1.5-1.5-1.4-1.4-1.5-1.20.8-1.1-0.1-0.2
Short access day 1 locomotion1.82.24.3-1.6-1.9-1.8-1.8-1.6-2.1-1.7-1.20.4-1.3-0.8-0.5
Short access day 10 total locomotion2.95.49.6-2.7-3.1-2.9-3.0-2.6-2.5-2.9-1.91.4-1.8-0.5-0.2
Short access total locomotion2.42.95.4-1.9-2.3-2.1-2.2-1.9-2.0-2.1-1.40.6-1.3-0.5-0.2
One hour access (0.3 mA shock)0.91.12.5-1.2-1.6-1.4-1.1-1.3-1.1-1.2-0.70.0-0.80.20.1
Compulsive drug intake0.81.02.70.70.80.91.00.80.61.00.3-0.71.61.41.4
One hour access (shock baseline)1.11.82.9-1.4-1.6-1.6-1.5-1.4-1.2-1.6-0.70.5-1.7-0.9-1.1
Social response proportion0.40.43.00.4-0.40.20.50.70.20.20.9-1.70.3-0.2-0.3
Social responses0.10.20.4-0.2-0.7-0.3-0.1-0.1-0.1-0.30.3-0.7-0.5-0.5-0.4
Social time0.30.41.7-0.2-1.1-0.5-0.0-0.5-0.3-0.20.2-1.30.10.50.8
Soleus weight0.20.41.6-0.8-1.3-0.8-0.6-0.5-0.7-0.9-0.4-0.3-0.30.30.3
Bone: stiffness0.30.51.4-1.2-0.9-0.9-0.8-0.6-1.0-0.5-0.90.40.10.30.2
Tibialis anterior weight0.82.810.30.1-1.2-0.4-0.30.8-0.2-1.41.2-1.3-2.5-3.0-3.2
Time to tail flick, vehicle, before self-admin1.11.14.3-0.20.30.10.3-0.3-0.20.9-0.70.21.82.02.1
Time to tail flick, vehicle, after self-admin0.10.10.4-0.50.1-0.2-0.4-0.1-0.7-0.3-0.60.5-0.1-0.2-0.0
Time to tail flick, test, before self-admin0.30.30.80.70.00.40.60.40.90.30.7-0.70.40.20.3
Time to tail flick, test, after self-admin0.10.10.3-0.20.4-0.0-0.20.2-0.0-0.2-0.30.5-0.1-0.10.1
Delta time to tail flick, vehicle, before/after SA1.41.33.4-1.0-0.7-1.0-1.4-0.6-1.0-1.5-0.71.1-1.8-1.2-1.2
Delta time to tail flick, test, before/after SA0.10.10.6-0.40.6-0.0-0.20.2-0.2-0.1-0.40.7-0.4-0.3-0.3
Tibia length0.20.63.0-0.60.10.0-0.3-0.0-0.60.3-0.80.11.71.31.1
Ambulatory time before self-admin0.40.62.80.0-0.10.10.4-0.20.20.3-0.1-0.71.41.71.4
Ambulatory time after self-admin0.20.31.40.0-0.3-0.10.3-0.50.2-0.10.0-0.50.91.20.7
Bone: tissue strength1.11.12.41.01.01.21.21.21.01.50.9-1.01.40.10.2
Total heroin consumption0.81.03.2-0.7-0.6-0.7-0.4-1.3-0.2-0.2-0.91.10.51.61.8
Bone: trabecular number3.05.012.4-2.4-0.6-1.6-2.2-2.4-2.4-1.2-3.33.50.82.22.1
Bone: trabecular spacing1.72.35.51.3-0.10.71.41.31.50.42.3-2.3-1.2-1.9-1.8
Bone: trabecular thickness4.65.712.0-2.5-1.2-1.9-2.5-2.6-3.0-1.7-3.53.10.92.32.2
Bone: trabecular tissue density0.61.03.40.51.41.10.41.1-0.01.5-0.10.01.80.70.7
Water consumed over 24 hours0.10.20.3-0.5-0.6-0.2-0.6-0.1-0.5-0.3-0.50.50.30.30.3
Number of responses in last shaping day0.50.51.6-0.6-0.4-0.6-0.7-0.7-0.8-0.2-0.90.20.21.21.3