Hub : Genes

Ace

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Ace 0.46 0.15 7.0e-07 0.26 0.27 0.22 0.24 7.5e-07 5.0e-07 5.1e-06 1.7e-06
2 BLA gene expression Ace 0.17 0.08 6.3e-10 0.13 0.17 0.18 0.18 1.8e-07 1.5e-09 4.9e-10 5.5e-10
3 Liver gene expression Ace 0.08 0.04 3.7e-11 0.06 0.08 0.07 0.07 7.1e-07 4.6e-09 9.7e-09 2.8e-08
4 PL gene expression Ace 0.16 0.05 0.0e+00 0.29 0.28 0.28 0.29 1.2e-31 5.2e-30 3.0e-31 7.7e-32
5 Brain gene expression Ace 0.1 0.04 4.3e-10 0.1 0.07 0.09 0.1 7.2e-10 2.3e-07 2.3e-08 3.3e-09
6 IC gene expression Ace 0.41 0.11 0.0e+00 0.34 0.35 0.35 0.24 3.8e-15 1.2e-15 1.5e-15 1.2e-10
7 pVTA gene expression Ace 0.15 0.06 1.3e-14 0.18 0.18 0.18 0.2 1.6e-14 1.1e-14 4.2e-14 9.0e-16
8 NAcc gene expression Ace 0.11 0.04 1.7e-16 0.1 0.11 0.11 0.11 2.4e-14 1.2e-16 2.4e-16 2.2e-16
9 IL gene expression Ace 0.15 0.09 8.7e-03 0.14 0.07 0.1 0.1 2.7e-04 1.1e-02 1.7e-03 2.1e-03
10 Adipose gene expression Ace 0.1 0.04 3.5e-10 0.08 0.07 0.08 0.09 4.9e-09 9.6e-09 2.6e-09 9.9e-10
11 pVTA mRNA stability Ace 0.05 0.03 9.1e-04 0.01 0.03 0.03 0.03 2.6e-02 1.3e-03 1.2e-03 1.9e-03
12 Adipose mRNA stability Ace 0.19 0.07 7.6e-15 0.14 0.11 0.11 0.13 6.7e-15 1.3e-12 3.0e-12 2.5e-14
13 NAcc mRNA stability Ace 0.06 0.03 4.5e-05 0.03 0.02 0.03 0.02 2.5e-05 7.3e-04 1.0e-04 1.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.93.410.6-1.80.0-1.1-1.81.7-2.0-0.9-3.00.43.3-1.1-2.1-2.0
Area under the delay curve0.20.30.9-0.60.3-0.4-0.70.3-0.9-0.3-0.80.30.60.10.10.1
BMI with tail1.13.98.7-1.43.0-1.9-1.60.7-1.9-2.60.12.3-1.42.32.22.4
BMI without tail1.36.913.3-2.63.6-2.9-3.01.7-3.2-3.4-1.23.3-0.12.62.02.0
Body weight2.812.525.8-4.15.1-4.3-4.33.1-4.5-4.6-2.64.00.82.41.01.1
Weight adjusted by age0.20.62.10.8-0.50.70.7-0.60.70.71.0-0.7-1.4-0.10.30.6
Bone surface5.09.818.5-3.82.5-3.1-3.53.6-3.6-2.5-4.31.93.5-0.7-3.0-2.9
Bone volume4.18.216.6-3.52.0-2.8-3.33.2-3.4-2.3-4.11.73.6-0.5-2.5-2.4
Breakpoint value in progressive ratio session0.10.20.8-0.10.4-0.3-0.00.70.3-0.5-0.10.10.5-0.1-0.7-0.9
Number of licking bursts0.00.00.2-0.10.2-0.10.1-0.10.0-0.1-0.0-0.2-0.1-0.2-0.4-0.3
Context. condit. distance diff. score0.70.92.70.80.10.40.7-0.60.90.21.5-0.1-1.60.71.21.4
Locomotion velocity, session 11.41.63.5-1.60.7-1.1-1.71.1-1.5-0.5-1.90.81.7-0.6-1.2-1.3
Locomotion distance, session 10.20.30.7-0.6-0.2-0.2-0.60.0-0.70.3-0.90.10.8-0.6-0.5-0.4
Locomotion velocity, session 20.60.72.1-0.80.2-0.6-0.70.9-0.1-0.1-1.00.61.3-0.2-1.5-1.4
Locomotion distance, session 20.10.10.40.0-0.40.20.2-0.20.40.6-0.0-0.00.3-0.3-0.4-0.1
Locomotion velocity, session 30.20.30.80.2-0.40.40.2-0.00.30.6-0.0-0.90.1-0.8-0.9-0.6
Locomotion distance, session 30.30.31.6-0.30.2-0.1-0.00.5-0.10.1-0.5-0.30.4-0.7-1.2-0.9
Stereotopy head waving bouts, day 30.40.41.40.3-1.20.60.2-0.20.00.6-0.4-0.70.9-1.1-0.4-0.6
Stereotopy head waving duration, day 30.20.31.00.5-1.00.70.5-0.60.30.50.3-0.60.1-0.30.50.3
Locomotion velocity, session 70.30.40.90.7-0.90.70.7-0.20.60.80.3-0.80.0-0.7-0.4-0.1
Locomotion distance, session 70.10.20.50.5-0.30.30.7-0.30.40.40.50.2-0.30.20.20.6
Stereotopy head waving bouts, day 70.60.71.70.5-1.10.80.6-0.40.71.0-0.1-1.10.4-1.3-1.0-1.1
Stereotopy head waving duration, day 71.31.63.71.1-1.91.51.2-1.11.51.60.5-1.70.3-1.3-0.7-0.9
Locomotion velocity, session 80.50.61.6-0.61.3-0.7-0.7-0.1-0.1-0.80.40.7-0.81.10.70.9
Locomotion distance, session 80.30.41.80.30.00.10.3-0.30.60.10.80.3-0.51.01.01.3
Degree of sensitization distance0.50.62.20.10.2-0.10.0-0.6-0.1-0.10.60.9-0.61.11.51.5
Degree of sensitization stereotypy0.91.11.70.9-1.21.11.0-0.71.31.30.5-1.3-0.2-1.3-1.0-1.0
Conditioned locomotion0.50.51.6-0.30.4-0.5-0.20.6-0.3-0.9-0.11.10.71.31.01.0
Cocaine response after cond. corrected0.30.41.60.20.10.20.5-0.0-0.10.60.1-0.8-1.0-1.0-1.3-0.8
Cocaine response after cond. not corrected1.01.56.90.1-0.10.30.50.40.20.9-0.3-1.3-0.6-2.0-2.6-2.1
Cocaine response before conditioning0.70.83.1-0.1-0.50.1-0.20.70.20.4-0.7-0.71.0-1.4-1.8-1.7
Saline control response1.42.06.5-0.81.6-1.4-0.91.0-0.6-1.8-0.12.10.12.51.51.3
Bone: connectivity density2.43.810.3-2.10.6-1.5-1.92.1-2.0-1.1-3.00.93.2-0.8-2.1-1.9
Bone: cortical apparent density2.43.89.02.3-3.02.62.1-2.21.72.41.3-2.4-0.1-1.40.70.8
Bone: cortical area1.72.85.6-1.91.3-1.4-1.91.8-2.2-1.1-2.40.51.6-0.9-2.0-1.9
Bone: cortical porosity8.89.616.7-3.33.4-3.3-3.04.1-2.8-2.5-3.41.81.8-0.9-4.0-4.1
Bone: cortical porosity6.77.412.3-3.03.2-2.9-2.73.5-2.7-2.5-3.01.51.3-0.8-3.2-3.3
Bone: cortical thickness3.15.112.61.9-3.02.71.7-1.91.12.80.3-3.5-0.0-3.6-1.9-1.8
Bone: cortical thickness2.63.16.21.6-2.42.01.5-1.31.32.10.3-2.50.1-2.5-1.7-1.7
Bone: cortical tissue density2.33.78.82.3-3.02.62.0-2.11.72.31.3-2.3-0.0-1.30.70.8
Condit. Reinf. active minus inactive responses2.12.44.3-1.71.6-1.9-1.62.1-1.5-1.8-1.61.91.30.9-0.6-0.7
Condit. Reinf. active-inactive response ratio0.70.82.2-0.90.9-1.1-0.71.5-0.7-1.0-0.91.10.60.2-0.6-0.6
Condit. Reinf. active responses2.73.45.4-2.11.8-2.2-2.02.2-1.8-2.2-1.92.31.81.6-0.2-0.2
Condit. Reinf. inactive responses1.21.52.5-1.50.9-1.3-1.51.0-1.4-1.3-1.31.41.61.30.40.5
Incentive salience index mean2.22.95.0-1.91.4-1.9-1.72.2-1.6-1.7-2.11.62.10.4-1.2-1.3
Condit. Reinf. lever presses0.71.14.6-1.10.4-0.8-1.01.0-0.6-0.8-1.50.62.1-0.1-1.2-0.9
Condit. Reinf. active minus inactive responses4.97.512.6-3.32.4-3.0-2.93.5-2.9-2.5-3.52.43.00.7-2.1-2.1
Condit. Reinf. active-inactive response ratio3.14.98.7-2.61.7-2.3-2.32.8-2.1-1.8-2.91.62.50.1-2.3-2.3
Condit. Reinf. active responses5.78.113.5-3.42.7-3.3-3.13.7-3.0-3.0-3.33.13.01.6-1.1-1.2
Condit. Reinf. inactive responses1.52.24.3-1.41.2-1.6-1.41.6-1.4-1.7-1.22.11.52.01.00.7
Condit. Reinf. lever presses1.72.54.3-1.81.6-1.8-1.72.1-1.5-1.5-1.91.71.70.9-1.0-1.0
Condit. Reinf. lever reinforcers received5.37.412.5-3.22.5-3.1-2.93.5-2.9-2.8-3.22.92.91.4-1.2-1.3
Conditioned reinforcement - actives0.20.91.9-0.81.2-1.0-1.00.9-0.9-0.8-0.11.0-0.21.11.41.0
Conditioned reinforcement - inactives0.41.12.5-1.21.6-1.3-1.31.4-1.3-1.1-0.80.90.20.50.0-0.1
Conditioned locomotion2.23.36.2-2.02.3-2.2-2.22.5-2.1-2.0-1.62.00.81.20.4-0.1
Patch foraging indifference point 0 sec1.95.27.6-2.52.1-2.6-2.52.4-2.6-2.7-2.32.82.22.40.70.8
Patch foraging indifference point AUC0.40.81.3-0.91.1-1.0-1.10.7-0.9-1.1-0.31.10.20.91.01.0
Delay disc. indifference point, 0s delay0.20.30.80.5-0.90.70.6-0.50.40.40.2-0.70.3-0.30.20.4
Delay disc. indifference point, 16s delay0.60.82.1-1.11.2-1.0-1.10.8-1.5-0.9-1.00.90.50.50.30.2
Delay disc. indifference point, 2s delay0.80.83.0-1.2-0.2-0.6-1.20.5-1.3-0.4-1.50.41.70.1-0.3-0.1
Delay disc. indifference point, 24s delay1.21.93.8-1.61.7-1.5-1.60.9-2.0-1.4-1.11.60.61.20.91.0
Delay disc. indifference point, 4s delay0.60.61.90.4-0.70.60.3-0.10.20.9-0.1-1.0-0.1-1.4-1.4-1.3
Delay disc. indifference point, 8s delay0.10.20.6-0.2-0.40.2-0.3-0.0-0.60.2-0.7-0.10.8-0.5-0.1-0.1
Indifference point function ln k0.20.51.50.1-0.90.40.3-0.1-0.10.4-0.6-0.71.0-0.6-1.2-1.0
Indifference point function log k0.20.51.50.1-0.90.40.3-0.1-0.10.4-0.6-0.71.0-0.6-1.2-1.0
Patch foraging total patch changes 0 sec1.95.68.1-2.72.3-2.7-2.62.6-2.8-2.8-2.42.92.22.20.50.6
Patch foraging total patch changes 12 sec3.44.69.1-2.22.0-2.4-2.31.8-1.9-2.5-1.53.01.72.71.61.6
Patch foraging total patch changes 18 sec1.22.75.1-1.82.2-2.1-1.71.6-1.7-2.1-1.22.30.81.60.30.3
Patch foraging total patch changes 24 sec1.24.05.9-2.41.9-2.2-2.32.3-2.4-2.1-2.32.32.11.20.2-0.1
Patch foraging total patch changes 6 sec1.72.94.2-2.01.9-2.0-2.02.0-2.0-1.9-1.71.91.41.40.0-0.0
Patch foraging time to switch 0 sec0.10.50.90.7-0.70.70.7-0.80.90.90.4-0.7-0.5-0.6-0.7-1.0
Patch foraging water rate 0 sec0.72.74.8-1.91.8-1.9-2.01.7-2.2-2.0-1.71.81.41.10.20.5
Patch foraging water rate 12 sec0.31.13.50.6-0.50.90.6-0.70.21.10.1-1.5-0.9-1.9-1.6-1.4
Patch foraging water rate 18 sec0.30.72.8-0.4-0.50.1-0.30.4-0.40.3-1.1-0.51.1-1.1-1.7-1.4
Patch foraging water rate 24 sec0.10.10.7-0.10.10.10.1-0.10.00.3-0.1-0.3-0.2-0.5-0.8-0.6
Patch foraging water rate 6 sec0.50.71.6-0.6-0.1-0.2-0.50.7-1.0-0.2-1.3-0.31.2-1.0-1.1-1.2
Seeking ratio, delayed vs. immediate footshock0.30.41.20.30.30.10.2-0.60.3-0.40.90.5-1.10.71.01.1
Distance traveled before self-admin0.40.82.80.3-0.10.40.70.00.30.60.0-1.2-0.8-1.5-1.7-1.5
Distance traveled after self-admin0.20.41.30.30.40.10.60.40.60.30.5-0.5-1.1-0.7-1.0-0.6
Extensor digitorum longus weight2.610.524.73.0-0.82.22.7-4.12.30.84.4-0.8-4.22.14.95.0
Bone: elastic displacement1.41.74.91.1-1.41.41.0-0.90.91.60.4-1.9-0.5-2.2-1.2-1.4
Bone: elastic work0.60.82.3-0.50.1-0.1-0.60.6-0.70.1-1.1-0.60.7-1.5-1.3-1.5
Bone: endosteal estimation10.224.940.5-5.96.4-6.3-5.66.3-5.2-5.6-4.85.73.22.8-1.7-1.6
Bone: endosteal perimeter10.926.747.6-6.36.9-6.6-5.96.1-5.6-6.1-4.75.82.53.2-1.2-1.1
Epididymis fat weight0.21.22.4-1.11.4-1.2-1.20.7-1.3-1.2-0.51.50.11.40.91.0
Delta time in closed arm before/after self-admin0.50.51.90.2-0.50.40.2-0.10.20.6-0.2-0.70.1-1.4-1.2-1.0
Delta time in open arm before/after self-admin1.21.46.40.4-0.20.10.2-0.50.3-0.20.90.50.02.12.52.5
Diff in mean of infusions in LGA sessions1.12.04.11.8-1.41.71.6-2.01.81.41.6-1.4-0.6-0.20.60.6
Delay discount exponential model param0.30.31.10.8-0.50.50.9-0.41.00.40.8-0.4-0.6-0.2-0.1-0.2
Extinction: sum of active levers before priming0.30.41.80.30.1-0.00.3-0.00.3-0.30.70.20.01.21.21.3
Active lever presses in extinction session 61.31.32.5-1.21.6-1.4-1.21.6-1.1-1.6-1.01.20.60.9-0.4-0.2
Bone: final force1.32.04.6-1.50.8-0.9-1.41.6-1.6-0.4-2.0-0.01.1-1.5-2.2-1.9
Bone: final moment1.52.45.7-1.50.8-0.9-1.41.7-1.6-0.4-2.1-0.11.3-1.7-2.4-2.2
Food consumed during 24 hour testing period1.83.76.6-1.92.6-2.1-2.21.2-1.8-2.4-0.82.40.52.51.51.7
Glucose1.01.64.31.3-0.71.21.5-1.51.21.31.5-1.5-2.1-0.9-0.1-0.1
Heart weight0.20.31.40.10.50.20.3-0.5-0.40.20.4-0.7-1.2-0.80.10.0
Delay discount hyperbolic model param0.30.41.10.8-0.40.50.9-0.41.10.40.9-0.4-0.7-0.10.0-0.1
Intermittent access intake day 1-15 change0.10.31.70.30.5-0.10.2-0.20.4-0.20.80.0-1.30.80.10.6
Intermittent access intake escalation0.10.51.5-0.21.1-0.6-0.30.2-0.1-0.80.50.5-1.21.20.10.6
Intermittent access intake escalation 20.30.51.5-0.31.2-0.7-0.40.5-0.2-0.90.30.7-0.91.10.00.5
Intermitt. access day 1 inactive lever presses0.33.65.4-2.11.8-2.2-2.32.2-2.0-2.1-2.22.12.01.4-0.8-0.3
Intermitt. access day 15 inactive lever presses0.42.43.6-1.51.2-1.6-1.91.9-1.8-1.8-1.91.71.81.2-0.5-0.2
Intermitt. access escalation Index0.82.64.41.8-1.31.72.1-1.71.91.51.8-1.8-2.0-1.5-0.3-0.4
Intermittent access day 1 total infusions0.30.91.7-1.31.1-1.2-1.21.2-1.2-1.0-1.01.00.70.40.0-0.1
Intermittent access day 15 total infusions0.92.25.1-1.42.3-1.7-1.51.3-1.4-1.8-0.31.5-0.61.81.21.2
Intermittent access terminal intake (last 3 days)1.93.36.6-1.92.6-2.2-2.01.9-1.8-2.2-0.82.10.12.11.21.1
Intermittent access total infusions2.32.84.9-1.92.2-2.0-1.91.7-1.7-2.0-1.01.90.41.71.21.0
Intermittent access day 1 locomotion2.13.86.6-2.42.6-2.4-2.52.6-2.3-2.1-1.91.91.00.6-0.1-0.7
Intermittent access day 15 total locomotion1.35.09.7-2.63.1-2.8-2.82.2-2.3-2.8-1.42.70.52.01.20.8
Intermittent access total locomotion5.76.911.3-3.23.3-3.3-3.43.0-2.9-3.0-2.33.01.51.80.50.2
Intermittent access standard deviation0.10.71.2-0.91.1-0.9-1.10.9-0.7-1.0-0.50.90.50.90.40.6
Left kidney weight0.10.73.2-0.1-0.40.40.2-0.1-0.20.7-0.5-0.90.1-1.8-1.3-1.4
Right kidney weight0.10.73.3-0.70.1-0.1-0.60.3-0.80.3-0.9-0.60.1-1.8-1.2-1.3
Cocaine induced anxiety0.30.94.00.4-0.70.60.6-0.00.20.9-0.2-1.10.1-2.0-1.4-1.7
Post-drug Anxiety0.70.83.30.5-0.70.80.6-0.40.30.90.1-1.2-0.4-1.8-1.1-1.4
Baseline Anxiety0.10.10.40.4-0.10.30.2-0.50.20.00.5-0.3-0.70.20.50.4
Tail length1.79.315.5-3.73.0-3.4-3.93.6-3.6-3.0-3.73.03.20.8-1.4-1.3
Length with tail1.77.613.6-3.73.3-3.3-3.72.8-3.4-2.9-3.02.82.10.7-0.5-0.7
Length without tail0.10.51.1-1.11.1-0.8-1.00.3-1.0-0.8-0.60.70.20.10.30.2
Times rat made contact with spout0.60.72.4-1.01.5-1.0-1.00.7-0.8-1.0-0.71.00.40.2-0.2-0.4
Lifetime Intake2.63.25.0-2.12.2-2.2-2.11.8-2.0-2.1-1.32.10.71.81.00.9
Liver weight, left3.35.79.1-3.02.6-2.7-2.92.8-2.2-2.3-2.72.12.10.1-2.1-2.0
Liver weight, right1.11.97.50.3-1.20.90.2-0.50.11.4-0.8-1.40.7-2.7-2.3-2.0
Locomotor activity0.30.41.0-0.71.0-0.9-0.61.0-0.3-0.5-0.20.80.00.80.20.2
Locomotor testing distance0.41.12.8-1.01.6-1.4-1.01.7-0.7-1.0-0.51.3-0.01.10.1-0.0
Locomotor testing rearing0.30.92.9-0.41.7-1.2-0.51.50.1-1.00.21.4-0.51.30.2-0.0
Locomotion in novel chamber0.81.04.4-0.10.20.10.10.10.10.8-0.1-0.6-1.0-1.9-1.9-2.1
Locomotion in novel chamber post-restriction0.41.32.7-1.61.3-1.4-1.21.3-1.6-1.3-1.30.80.80.40.1-0.1
Fecal boli incidents, locomotor time 10.00.10.5-0.00.7-0.30.00.5-0.1-0.20.30.2-0.60.30.20.2
Change in fecal boli incidents, locomotor task0.10.10.60.1-0.20.20.1-0.5-0.20.00.20.2-0.00.30.80.7
Time >=10cm from walls, locomotor time 12.22.74.21.8-1.21.72.0-1.52.01.81.8-1.9-1.9-1.3-0.8-0.5
Bouts of movement, locomotor time 10.20.20.50.6-0.70.70.4-0.40.30.70.3-0.30.1-0.40.40.6
Total resting periods, locomotor time 10.20.20.60.6-0.70.70.3-0.50.20.80.2-0.30.2-0.60.30.5
Rest time, locomotor task time 10.10.20.50.2-0.70.30.3-0.10.10.5-0.3-0.10.7-0.5-0.5-0.1
Distance moved, locomotor task time 10.10.30.6-0.60.7-0.6-0.8-0.1-0.6-0.8-0.30.4-0.10.50.3-0.0
Vertical activity count, locomotor time 10.00.30.6-0.70.6-0.6-0.80.6-0.7-0.6-0.60.10.10.2-0.5-0.8
Time >=10cm from walls, locomotor time 20.30.73.70.4-0.00.30.40.20.60.30.1-0.8-0.5-1.1-1.9-1.6
Bouts of movement, locomotor time 20.10.20.40.7-0.60.60.5-0.60.40.20.5-0.4-0.30.00.10.5
Total resting periods, locomotor time 20.10.40.80.9-0.90.80.8-0.80.60.50.6-0.6-0.5-0.30.00.4
Rest time, locomotor task time 21.83.04.92.1-2.12.12.2-2.01.81.71.8-1.9-1.4-1.00.60.7
Distance moved, locomotor task time 20.40.61.5-0.70.7-0.6-0.90.4-0.4-0.6-0.80.40.8-0.1-1.2-1.2
Vertical activity count, locomotor time 21.02.43.5-1.71.4-1.7-1.81.9-1.4-1.5-1.81.31.90.8-1.3-1.2
Light reinforcement 10.31.33.7-0.7-0.2-0.5-0.80.3-1.1-1.1-1.00.81.91.91.31.6
Light reinforcement 20.61.34.9-1.0-0.3-0.6-1.21.0-1.4-0.9-1.60.72.21.00.40.7
Bone: marrow area9.824.039.3-5.86.3-6.1-5.56.3-5.1-5.5-4.85.53.12.7-1.8-1.7
Bone: maximum diameter4.28.413.5-3.73.1-3.3-3.43.4-3.5-2.9-3.52.42.20.5-1.9-1.9
Bone: maximum force1.52.95.9-2.21.6-1.6-2.01.7-2.4-1.2-2.30.91.2-0.8-1.6-1.5
Bone: maximum moment1.73.26.1-2.21.6-1.6-2.11.9-2.5-1.1-2.50.81.5-1.0-1.8-1.8
Mean time between licks in bursts0.10.51.6-0.41.1-0.5-0.30.3-0.7-0.40.40.4-1.30.50.90.7
Mean num. licks in bursts0.10.30.8-0.50.8-0.5-0.70.3-0.6-0.6-0.20.90.30.60.70.4
Cd content in liver4.24.68.32.6-2.02.32.6-2.42.61.92.9-1.4-2.3-0.31.91.7
Co content in liver1.71.93.61.6-1.21.41.4-1.71.81.01.9-1.0-1.40.11.51.3
Cu content in liver0.40.51.5-0.80.1-0.7-0.80.7-0.7-0.8-1.00.61.20.70.1-0.0
Fe content in liver0.20.20.80.1-0.40.20.20.30.60.5-0.2-0.40.5-0.4-0.7-0.9
K content in liver0.40.41.8-0.8-0.0-0.5-0.70.5-0.4-0.4-0.90.41.40.70.00.1
Mg content in liver0.70.82.90.6-1.70.90.6-1.00.80.60.1-0.31.30.60.91.0
Mn content in liver0.80.94.7-0.2-1.50.50.00.10.10.8-1.1-0.62.2-0.7-0.9-0.8
Na content in liver0.30.41.5-0.7-0.1-0.6-0.50.5-0.1-0.7-0.70.51.20.8-0.0-0.1
Rb content in liver3.03.47.22.0-2.72.32.0-2.22.22.41.3-2.3-0.4-1.3-0.2-0.2
Se content in liver0.91.12.11.1-1.21.21.3-1.51.10.91.1-0.9-0.7-0.11.10.9
Sr content in liver0.70.61.1-1.00.9-0.9-1.01.1-1.0-1.0-0.80.60.30.1-0.4-0.3
Zn content in liver0.30.40.90.5-1.00.70.7-0.70.50.70.3-0.6-0.3-0.7-0.2-0.5
Bone: minimum diameter10.520.232.8-5.55.7-5.5-5.35.3-5.3-5.1-4.54.72.92.2-1.2-1.2
Time in familiar zone, hab. session 10.90.92.7-0.41.2-0.8-0.3-0.1-0.3-1.00.41.3-0.51.61.31.5
Time in novel zone, hab. session 11.11.23.00.8-1.31.10.6-0.30.51.2-0.1-1.50.0-1.7-1.4-1.5
Total zone transitions, hab. session 10.10.10.4-0.40.6-0.3-0.4-0.1-0.4-0.1-0.00.3-0.10.10.30.5
Total locomotion distance, hab. session 10.91.22.7-1.30.6-0.9-1.40.9-1.4-0.5-1.60.61.6-0.6-1.2-0.8
Locomotion velocity, hab. session 11.01.52.9-1.60.9-1.2-1.61.1-1.6-0.8-1.70.91.6-0.3-0.9-0.6
Time in familiar zone, hab. session 20.91.02.4-0.51.6-1.0-0.40.4-0.0-0.90.51.5-0.91.51.11.1
Time in novel zone, hab. session 21.31.43.60.3-1.70.90.3-0.3-0.21.0-0.9-1.51.1-1.9-1.6-1.5
Total zone transitions, hab. session 20.10.21.0-0.10.2-0.1-0.1-0.50.20.10.40.3-0.10.50.71.0
Total locomotion distance, hab. session 20.40.51.6-0.60.0-0.4-0.8-0.1-0.7-0.3-0.60.81.30.80.81.1
Locomotion velocity, hab. session 20.40.51.4-0.60.0-0.4-0.8-0.2-0.7-0.3-0.50.81.20.70.81.2
Novel to familiar place preference ratio0.30.40.9-0.80.7-0.7-0.80.9-0.9-0.7-0.70.40.4-0.1-0.3-0.6
Novelty place preference0.20.20.5-0.50.4-0.4-0.50.6-0.6-0.4-0.60.10.3-0.2-0.4-0.7
Time in novel zone, NPP test0.20.20.9-0.40.3-0.3-0.40.7-0.5-0.2-0.5-0.00.2-0.5-0.6-1.0
Total zone transitions, NPP test0.10.20.6-0.4-0.3-0.0-0.5-0.5-0.30.3-0.40.10.80.00.20.6
Total locomotion distance, NPP test0.60.83.2-1.10.2-0.7-1.20.5-1.1-0.2-1.40.71.8-0.2-0.6-0.2
Locomotion velocity, NPP test0.40.61.9-0.90.2-0.6-1.10.1-1.1-0.4-1.00.81.40.50.30.7
Intraocular pressure0.81.32.7-0.81.6-1.2-0.90.8-1.5-1.2-0.21.4-0.71.31.31.0
Delta distance traveled before/after self-admin0.20.20.60.6-0.10.40.5-0.20.80.10.8-0.2-0.40.20.30.5
Delta ambulatory time before/after self-admin0.10.10.40.20.2-0.00.10.20.2-0.20.40.3-0.10.30.60.7
Parametrial fat weight0.61.43.3-1.30.3-0.7-1.21.1-1.4-0.5-1.80.21.6-1.0-1.6-1.4
Pavlov. Cond. lever latency2.12.64.51.9-1.41.61.8-1.81.51.32.1-1.0-2.10.31.71.4
Pavlov. Cond. magazine entry latency3.84.99.4-2.71.7-2.3-2.62.4-2.2-2.2-2.91.93.10.4-1.5-1.2
Pavlov. Cond. change in total contacts3.33.57.9-2.21.3-1.9-2.12.2-1.8-1.8-2.51.52.80.4-1.4-1.2
Pavlov. Cond. index score3.34.27.7-2.51.7-2.2-2.42.2-2.0-2.0-2.71.72.80.3-1.6-1.2
Pavlov. Cond. latency score2.63.35.7-2.21.6-1.9-2.12.0-1.8-1.8-2.31.52.40.3-1.4-1.1
Pavlov. Cond. lever contacts2.53.05.1-2.01.5-1.8-1.92.0-1.6-1.5-2.21.22.3-0.1-1.7-1.4
Pavlov. Cond. magazine entry number2.93.78.72.2-1.21.92.2-2.21.91.82.6-1.7-3.0-0.41.31.1
Pavlov. Cond. intertrial magazine entries1.41.75.4-0.81.1-1.1-0.80.5-1.0-1.2-0.01.7-0.12.32.11.7
Pavlov. Cond. lever-magazine prob. diff.3.64.58.2-2.61.7-2.2-2.42.3-2.2-2.0-2.81.62.90.2-1.8-1.5
Pavlov. Cond. response bias5.67.015.3-3.11.6-2.5-2.93.1-2.6-2.1-3.71.83.9-0.2-2.5-2.2
Pavlov. Cond. lever latency0.30.51.00.8-0.70.80.7-1.00.60.60.8-0.7-0.5-0.40.50.5
Pavlov. Cond. magazine entry latency1.82.54.21.8-1.21.71.9-1.61.91.81.9-1.8-2.0-1.00.10.1
Pavlov. Cond. change in total contacts0.20.41.4-0.60.7-0.8-0.40.7-0.0-0.7-0.11.10.21.20.60.4
Pavlov. Cond. index score0.00.10.2-0.00.2-0.10.20.20.30.10.2-0.1-0.5-0.1-0.4-0.5
Pavlov. Cond. latency score0.10.20.70.10.10.10.40.20.50.40.2-0.4-0.6-0.4-0.7-0.8
Pavlov. Cond. lever contacts0.20.30.5-0.70.5-0.6-0.60.7-0.5-0.5-0.60.70.50.6-0.3-0.2
Pavlov. Cond. magazine entry number2.73.55.3-2.11.7-2.1-2.31.7-2.3-2.3-1.92.22.01.60.30.4
Pavlov. Cond. intertrial magazine entries7.215.823.3-4.64.2-4.6-4.84.0-4.8-4.8-4.04.63.53.20.30.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.10.10.10.30.20.40.30.3-0.2-0.6-0.2-0.4-0.5
Pavlov. Cond. response bias0.00.00.1-0.10.1-0.10.00.30.1-0.0-0.00.1-0.10.2-0.1-0.2
Time in closed arm before self-admin0.10.10.40.2-0.10.20.1-0.20.3-0.10.1-0.5-0.2-0.3-0.5-0.6
Time in closed arm after self-admin0.91.02.10.9-0.60.90.9-0.81.10.80.8-1.3-1.1-1.5-0.8-1.1
Time in open arm before self-admin1.21.54.40.8-0.60.91.0-0.60.71.30.6-1.5-1.5-2.1-1.6-1.5
Time in open arm after self-admin0.50.62.1-0.20.5-0.4-0.20.1-0.3-0.40.40.8-0.51.31.41.4
Bone: periosteal estimation7.417.628.3-5.14.8-4.9-4.85.3-4.8-4.3-4.83.93.31.2-2.5-2.3
Bone: periosteal perimeter4.28.213.0-3.63.5-3.4-3.33.6-3.4-2.9-3.22.21.60.2-2.2-2.0
Bone: post-yield work1.11.95.2-1.62.3-1.7-1.31.7-1.5-1.4-1.11.30.10.1-0.9-0.9
Progressive ratio test 1 active lever presses1.83.15.2-2.12.0-2.1-2.12.3-2.2-1.9-1.71.81.11.30.20.0
Progressive ratio test 1 breakpoint2.13.65.5-2.32.1-2.2-2.32.3-2.3-2.1-1.92.01.31.50.30.2
Progressive ratio test 1 inactive lever presses1.43.85.6-2.32.3-2.4-2.32.3-2.2-2.1-1.92.11.41.60.10.1
Progressive ratio test 2 active lever presses4.36.09.3-2.93.0-3.0-2.93.0-3.0-2.8-2.32.61.21.90.40.2
Progressive ratio test 2 breakpoint5.06.59.9-3.03.1-3.1-3.03.1-3.1-2.9-2.32.71.22.00.40.2
Progressive ratio test 2 inactive lever presses1.23.86.0-2.22.1-2.2-2.41.8-2.4-2.3-1.72.21.21.81.11.0
Incentive Sensitization - Responses1.33.66.7-2.32.6-2.4-2.22.2-2.3-2.3-1.62.10.51.40.20.0
Incentive Sensitization - Breakpoint1.63.57.0-2.32.6-2.4-2.22.2-2.2-2.3-1.52.00.41.40.20.0
Sum of active levers in priming session hrs 5-60.90.81.81.1-0.50.71.1-0.91.10.51.3-0.5-0.60.81.01.1
Progressive ratio0.00.10.5-0.40.5-0.3-0.3-0.0-0.4-0.4-0.0-0.0-0.00.70.50.3
Food seeking constrained by brief footshock1.92.45.4-1.62.3-2.0-1.61.5-1.0-2.1-0.62.00.41.80.80.8
Seeking ratio, punishment vs. effort0.40.92.4-1.01.2-1.3-1.01.2-0.7-1.2-0.71.60.50.6-0.10.1
Retroperitoneal fat weight0.41.83.3-1.61.3-1.5-1.81.1-1.8-1.5-1.51.61.40.50.10.3
Reaction time number correct0.10.30.80.4-0.40.60.6-0.70.10.60.3-0.9-0.6-0.8-0.3-0.1
Reaction time mean minus median0.00.30.60.7-0.70.60.7-0.50.50.60.4-0.5-0.3-0.5-0.1-0.1
Reaction time mean minus median AUC0.21.32.81.3-1.71.41.4-1.41.11.50.8-1.3-0.4-1.10.0-0.1
Reaction time num false alarms2.23.76.4-2.52.5-2.4-2.32.1-2.1-2.4-1.81.81.11.2-0.5-0.4
Reaction time num false alarms AUC1.94.37.1-2.72.5-2.5-2.52.3-2.3-2.6-2.21.91.61.2-0.5-0.4
Reaction time trials correct on left0.10.30.80.4-0.40.60.6-0.70.10.60.3-0.9-0.6-0.8-0.3-0.1
Reaction time trials on left0.10.30.80.3-0.40.60.6-0.7-0.00.60.2-0.9-0.5-0.9-0.3-0.2
Reaction time mean0.61.33.21.2-1.81.31.3-0.91.21.50.4-1.30.2-1.1-1.0-0.9
Reaction time mean AUC0.71.84.11.5-2.01.51.6-1.11.61.70.7-1.40.1-1.1-1.0-0.8
Median of all reaction times0.91.43.51.2-1.91.31.3-0.81.31.60.3-1.30.3-1.1-1.2-1.0
Reaction time omissions0.40.72.0-0.6-0.3-0.3-0.50.7-1.0-0.0-1.40.21.4-0.5-1.1-1.2
Reaction time false alarm rate2.73.75.8-2.42.3-2.4-2.42.2-1.9-2.4-1.92.01.51.3-0.5-0.5
Reaction time premature initiation rate0.71.11.9-1.01.1-1.1-1.11.2-1.3-1.4-0.91.20.70.80.80.3
Reaction time premature initiations0.20.61.5-0.80.9-0.8-0.80.7-1.2-1.1-0.70.80.40.40.80.4
Std. dev. reaction times0.20.61.70.8-1.30.90.9-0.70.71.00.2-0.70.2-0.8-0.5-0.5
Reaction time trials completed0.10.30.80.3-0.40.60.6-0.7-0.00.60.2-0.9-0.5-0.9-0.3-0.2
Reaction time trials AUC0.10.30.80.4-0.40.60.6-0.80.10.60.3-0.9-0.6-0.8-0.2-0.1
Run reversals in cocaine runway, females0.10.10.40.2-0.20.3-0.1-0.5-0.30.2-0.0-0.5-0.5-0.5-0.60.1
Run reversals in cocaine runway, males0.20.20.90.1-0.00.10.2-0.0-0.10.0-0.0-0.4-0.7-0.9-0.9-0.8
Latency to leave start box in cocaine runway0.10.20.30.5-0.40.50.5-0.20.40.30.3-0.6-0.4-0.5-0.3-0.4
Latency to leave start box in cocaine runway, F0.70.82.50.6-0.40.60.7-0.20.40.70.3-1.1-0.9-1.6-1.4-1.5
Latency to leave start box in cocaine runway, M0.30.31.10.2-0.1-0.00.00.10.3-0.40.20.30.41.01.01.0
Std. dev. time between licks in bursts0.10.10.70.2-0.20.10.2-0.20.00.00.40.2-0.30.50.70.9
Total sessions with >9 infusions0.30.40.9-0.50.8-0.6-0.50.4-0.6-0.60.00.5-0.40.81.00.7
Short access day 1 total inactive lever presses1.32.54.3-2.01.7-1.8-2.01.6-2.1-1.7-1.91.41.10.1-0.9-1.0
Short access day 10 total inactive lever presses0.10.40.7-0.40.2-0.4-0.70.3-0.8-0.7-0.70.50.80.80.20.8
Short access day 1 total infusions0.30.51.4-0.80.6-0.8-0.80.4-0.9-0.8-0.60.70.41.20.50.5
Short access day 10 total infusions1.82.94.6-2.02.1-2.1-2.11.8-1.9-2.1-1.42.00.91.60.40.6
Short access total infusions1.11.52.3-1.51.4-1.5-1.51.4-1.4-1.5-1.21.30.81.10.10.2
Short access day 1 locomotion1.32.24.3-1.61.9-1.8-1.81.6-2.1-1.7-1.21.60.41.30.80.5
Short access day 10 total locomotion1.45.69.6-2.73.1-2.9-3.02.6-2.5-2.9-1.92.81.41.80.50.2
Short access total locomotion2.03.05.4-1.92.3-2.1-2.21.9-2.0-2.1-1.41.90.61.30.50.2
One hour access (0.3 mA shock)0.91.12.5-1.21.6-1.4-1.11.3-1.1-1.2-0.71.20.00.8-0.2-0.1
Compulsive drug intake0.71.02.70.7-0.80.91.0-0.80.61.00.3-1.2-0.7-1.6-1.4-1.4
One hour access (shock baseline)0.71.82.9-1.41.6-1.6-1.51.4-1.2-1.6-0.71.60.51.70.91.1
Social response proportion0.30.43.00.40.40.20.5-0.70.20.20.9-0.2-1.7-0.30.20.3
Social responses0.10.20.4-0.20.7-0.3-0.10.1-0.1-0.30.30.5-0.70.50.50.4
Social time0.20.31.7-0.21.1-0.5-0.00.5-0.3-0.20.20.1-1.3-0.1-0.5-0.8
Soleus weight0.10.41.6-0.81.3-0.8-0.60.5-0.7-0.9-0.40.4-0.30.3-0.3-0.3
Bone: stiffness0.30.51.4-1.20.9-0.9-0.80.6-1.0-0.5-0.90.70.4-0.1-0.3-0.2
Tibialis anterior weight0.82.710.30.11.2-0.4-0.3-0.8-0.2-1.41.21.2-1.32.53.03.2
Time to tail flick, vehicle, before self-admin0.91.14.3-0.2-0.30.10.30.3-0.20.9-0.7-0.70.2-1.8-2.0-2.1
Time to tail flick, vehicle, after self-admin0.10.10.4-0.5-0.1-0.2-0.40.1-0.7-0.3-0.60.10.50.10.20.0
Time to tail flick, test, before self-admin0.20.30.80.7-0.00.40.6-0.40.90.30.7-0.2-0.7-0.4-0.2-0.3
Time to tail flick, test, after self-admin0.10.10.3-0.2-0.4-0.0-0.2-0.2-0.0-0.2-0.3-0.10.50.10.1-0.1
Delta time to tail flick, vehicle, before/after SA1.31.43.4-1.00.7-1.0-1.40.6-1.0-1.5-0.71.31.11.81.21.2
Delta time to tail flick, test, before/after SA0.10.10.6-0.4-0.6-0.0-0.2-0.2-0.2-0.1-0.4-0.20.70.40.30.3
Tibia length0.20.63.0-0.6-0.10.0-0.30.0-0.60.3-0.8-0.50.1-1.7-1.3-1.1
Ambulatory time before self-admin0.20.62.80.00.10.10.40.20.20.3-0.1-0.8-0.7-1.4-1.7-1.4
Ambulatory time after self-admin0.20.31.40.00.3-0.10.30.50.2-0.10.0-0.3-0.5-0.9-1.2-0.7
Bone: tissue strength1.11.12.41.0-1.01.21.2-1.21.01.50.9-1.2-1.0-1.4-0.1-0.2
Total heroin consumption0.80.93.2-0.70.6-0.7-0.41.3-0.2-0.2-0.90.31.1-0.5-1.6-1.8
Bone: trabecular number2.54.712.4-2.40.6-1.6-2.22.4-2.4-1.2-3.30.93.5-0.8-2.2-2.1
Bone: trabecular spacing1.52.15.51.30.10.71.4-1.31.50.42.3-0.1-2.31.21.91.8
Bone: trabecular thickness3.85.312.0-2.51.2-1.9-2.52.6-3.0-1.7-3.50.93.1-0.9-2.3-2.2
Bone: trabecular tissue density0.61.03.40.5-1.41.10.4-1.1-0.01.5-0.1-1.30.0-1.8-0.7-0.7
Water consumed over 24 hours0.10.20.3-0.50.6-0.2-0.60.1-0.5-0.3-0.50.20.5-0.3-0.3-0.3
Number of responses in last shaping day0.40.51.6-0.60.4-0.6-0.70.7-0.8-0.2-0.90.10.2-0.2-1.2-1.3