Hub : Genes

Ace

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Ace 0.45 0.14 1.7e-07 0.19 0.24 0.23 0.27 2.5e-05 1.6e-06 3.8e-06 4.7e-07
2 PL gene expression Ace 0.18 0.06 0.0e+00 0.26 0.27 0.28 0.28 6.8e-29 2.1e-29 2.6e-30 9.8e-31
3 NAcc gene expression Ace 0.09 0.04 6.3e-09 0.08 0.07 0.07 0.06 1.1e-09 1.1e-08 2.4e-08 7.1e-08
4 Liver gene expression Ace 0.08 0.03 2.5e-10 0.04 0.07 0.07 0.06 1.3e-05 2.7e-08 3.6e-08 1.1e-07
5 BLA gene expression Ace 0.16 0.07 9.3e-11 0.14 0.16 0.15 0.18 3.8e-08 3.9e-09 2.1e-08 1.0e-09
6 Brain gene expression Ace 0.1 0.04 4.1e-10 0.1 0.1 0.1 0.1 2.4e-09 3.8e-09 1.7e-09 7.9e-10
7 pVTA gene expression Ace 0.19 0.09 6.6e-07 0.18 0.14 0.15 0.15 2.6e-08 1.7e-06 6.7e-07 5.3e-07
8 Adipose gene expression Ace 0.1 0.04 4.4e-10 0.1 0.08 0.08 0.09 2.6e-11 8.6e-09 5.7e-09 7.5e-10
9 Brain mRNA stability Ace 0.06 0.04 8.7e-03 0.03 0.02 0.02 0.02 8.6e-04 6.6e-03 5.0e-03 5.7e-03
10 Adipose mRNA stability Ace 0.2 0.08 6.6e-15 0.14 0.11 0.13 0.13 1.7e-15 2.8e-12 3.0e-14 2.2e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density3.45.713.4-2.6-2.42.7-1.4-0.8-2.71.0-3.7-2.8-2.4
Area under the delay curve0.10.10.2-0.5-0.40.4-0.3-0.3-0.10.2-0.10.10.1
BMI with tail0.72.48.30.20.0-0.2-0.4-0.81.90.62.92.32.4
BMI without tail1.53.25.7-1.5-1.61.4-1.9-2.0-0.12.30.92.42.4
Body weight1.66.512.8-3.0-3.02.8-3.3-3.6-1.13.10.71.51.5
Weight adjusted by age0.80.92.01.11.0-1.00.70.71.3-0.61.40.80.6
Bone surface7.813.719.3-4.4-4.14.3-3.4-3.1-4.42.4-3.5-3.6-3.3
Bone volume6.611.216.0-4.0-3.84.0-3.0-2.5-3.92.2-3.6-3.1-2.8
Breakpoint value in progressive ratio session0.70.82.1-0.8-0.80.7-1.1-1.1-1.21.4-0.5-0.2-0.0
Number of licking bursts0.00.00.20.0-0.10.1-0.1-0.2-0.1-0.10.3-0.3-0.4
Context. condit. distance diff. score0.81.03.00.60.9-1.20.40.11.20.11.71.21.2
Locomotion velocity, session 11.71.82.9-1.6-1.51.4-1.1-1.0-1.70.9-1.7-1.1-1.1
Locomotion distance, session 10.20.21.0-0.5-0.50.4-0.2-0.2-0.5-0.1-1.0-0.2-0.5
Locomotion velocity, session 21.01.22.9-0.6-0.70.8-0.7-0.6-1.70.2-1.5-1.3-1.5
Locomotion distance, session 20.10.10.30.10.1-0.20.1-0.1-0.4-0.3-0.60.0-0.5
Locomotion velocity, session 30.20.20.80.10.3-0.10.50.50.3-0.5-0.2-0.7-0.9
Locomotion distance, session 30.30.31.5-0.3-0.20.4-0.1-0.2-0.5-0.2-0.4-0.9-1.2
Stereotopy head waving bouts, day 30.30.31.00.20.1-0.00.61.00.1-0.6-0.9-0.6-0.4
Stereotopy head waving duration, day 30.20.30.80.50.4-0.50.60.90.7-0.3-0.10.20.5
Locomotion velocity, session 70.20.20.50.20.5-0.50.70.60.5-0.7-0.1-0.2-0.3
Locomotion distance, session 70.10.20.90.20.4-0.50.20.10.30.00.30.90.4
Stereotopy head waving bouts, day 70.40.51.10.40.4-0.30.70.9-0.1-0.8-0.8-1.1-0.9
Stereotopy head waving duration, day 71.21.53.01.31.3-1.21.61.70.6-1.5-0.5-1.0-0.7
Locomotion velocity, session 80.50.61.6-0.7-0.50.2-0.9-1.30.10.91.00.70.7
Locomotion distance, session 80.20.31.40.20.4-0.70.1-0.00.40.30.41.20.9
Degree of sensitization distance0.70.73.50.10.1-0.5-0.2-0.40.50.60.71.91.6
Degree of sensitization stereotypy0.80.91.81.01.0-0.91.11.00.3-1.3-0.0-1.0-1.0
Conditioned locomotion0.40.51.2-0.3-0.40.4-0.6-0.3-0.60.9-0.61.11.0
Cocaine response after cond. corrected0.40.41.40.30.3-0.10.20.20.5-0.71.0-0.9-1.2
Cocaine response after cond. not corrected1.21.36.40.30.3-0.00.40.3-0.0-1.10.5-2.2-2.5
Cocaine response before conditioning0.70.83.2-0.1-0.00.10.30.4-0.8-0.5-1.1-1.7-1.8
Saline control response0.91.23.0-0.8-0.80.6-1.3-1.3-0.81.7-0.01.21.5
Bone: connectivity density3.96.212.6-2.7-2.52.7-1.7-1.2-3.11.2-3.6-2.6-2.5
Bone: cortical apparent density3.24.210.32.22.2-2.02.73.22.3-2.0-0.40.81.0
Bone: cortical area2.84.27.4-2.5-2.42.7-1.9-1.5-2.01.3-1.9-2.1-1.8
Bone: cortical porosity11.412.516.5-3.7-3.73.9-3.7-4.0-4.12.2-1.5-3.8-3.8
Bone: cortical porosity7.27.910.3-3.0-3.03.2-2.9-3.2-3.01.5-0.9-3.2-3.2
Bone: cortical thickness1.72.86.61.11.1-0.52.22.61.4-2.3-0.8-1.9-1.6
Bone: cortical thickness2.32.74.91.21.3-0.92.02.20.7-2.2-0.6-2.1-2.0
Bone: cortical tissue density3.24.210.12.22.2-2.02.73.22.2-1.9-0.40.81.1
Condit. Reinf. active minus inactive responses2.22.44.2-1.7-1.71.6-1.9-1.8-2.01.7-1.0-0.6-0.6
Condit. Reinf. active-inactive response ratio0.80.91.8-1.1-0.90.7-1.1-1.0-1.31.1-0.4-0.6-0.6
Condit. Reinf. active responses2.83.44.9-2.0-2.12.0-2.2-2.0-2.22.2-1.6-0.2-0.2
Condit. Reinf. inactive responses1.21.42.5-1.3-1.41.5-1.2-0.9-1.21.3-1.60.40.4
Incentive salience index mean2.73.35.8-1.9-2.02.0-1.9-1.8-2.41.6-1.9-1.4-1.2
Condit. Reinf. lever presses0.91.23.7-1.0-1.01.2-0.7-0.6-1.30.7-1.9-1.0-1.0
Condit. Reinf. active minus inactive responses6.37.714.1-3.1-3.02.9-2.9-2.8-3.82.3-2.7-1.7-2.1
Condit. Reinf. active-inactive response ratio5.25.49.9-2.4-2.42.5-2.2-2.0-3.21.7-2.4-2.0-2.3
Condit. Reinf. active responses5.57.613.4-3.1-3.13.0-3.2-2.9-3.72.8-2.6-0.8-1.1
Condit. Reinf. inactive responses1.31.62.7-1.3-1.31.2-1.5-1.2-1.41.6-1.20.91.0
Condit. Reinf. lever presses1.72.34.2-1.7-1.61.6-1.6-1.7-2.01.4-1.4-0.8-1.0
Condit. Reinf. lever reinforcers received4.96.912.2-2.9-3.02.9-3.0-2.7-3.52.5-2.5-1.0-1.2
Conditioned reinforcement - actives0.70.71.3-0.7-0.80.6-1.0-1.1-0.31.00.40.61.1
Conditioned reinforcement - inactives0.91.01.8-1.3-1.31.3-1.3-1.3-0.81.0-0.3-0.0-0.0
Conditioned locomotion2.12.53.9-2.0-2.01.9-2.0-1.9-1.61.8-0.5-0.20.2
Patch foraging indifference point 0 sec3.04.97.5-2.7-2.62.3-2.6-2.1-2.32.7-2.11.00.6
Patch foraging indifference point AUC0.81.01.7-0.9-1.00.8-1.1-1.3-0.31.3-0.11.11.2
Delay disc. indifference point, 0s delay0.50.51.50.80.8-0.70.91.20.7-0.60.00.30.1
Delay disc. indifference point, 16s delay0.30.30.8-0.7-0.70.9-0.8-0.7-0.40.5-0.10.10.2
Delay disc. indifference point, 2s delay0.60.62.2-1.0-0.90.8-0.5-0.2-0.90.5-1.5-0.1-0.2
Delay disc. indifference point, 24s delay1.61.62.6-1.4-1.51.5-1.5-1.6-0.71.3-0.31.11.0
Delay disc. indifference point, 4s delay0.70.72.10.50.6-0.50.70.60.4-1.10.4-1.3-1.4
Delay disc. indifference point, 8s delay0.10.10.40.0-0.0-0.00.40.50.1-0.3-0.7-0.1-0.1
Indifference point function ln k0.40.51.4-0.0-0.10.40.31.0-0.5-0.4-1.2-1.0-1.2
Indifference point function log k0.40.51.4-0.0-0.10.40.31.0-0.5-0.4-1.2-1.0-1.2
Patch foraging total patch changes 0 sec3.35.38.1-2.8-2.72.5-2.7-2.3-2.42.8-2.00.90.4
Patch foraging total patch changes 12 sec3.24.17.6-2.1-2.11.6-2.4-2.3-1.82.7-1.41.81.6
Patch foraging total patch changes 18 sec1.82.34.9-1.7-1.61.4-2.0-2.2-1.41.9-0.40.60.2
Patch foraging total patch changes 24 sec3.03.75.5-2.3-2.32.1-2.2-2.0-2.12.1-2.0-0.00.2
Patch foraging total patch changes 6 sec1.82.74.3-2.1-2.01.8-2.0-1.8-1.72.0-1.10.10.1
Patch foraging time to switch 0 sec0.10.20.70.50.5-0.30.50.40.1-0.50.2-0.8-0.6
Patch foraging water rate 0 sec1.21.93.2-1.8-1.81.7-1.6-1.6-1.31.4-0.90.40.2
Patch foraging water rate 12 sec0.71.12.60.50.7-0.61.00.80.8-1.50.8-1.6-1.6
Patch foraging water rate 18 sec0.50.72.8-0.4-0.30.40.10.4-0.6-0.6-1.1-1.4-1.7
Patch foraging water rate 24 sec0.10.10.7-0.10.0-0.00.0-0.1-0.1-0.30.3-0.2-0.8
Patch foraging water rate 6 sec0.40.61.8-0.6-0.50.60.00.3-0.6-0.2-1.1-1.3-1.3
Seeking ratio, delayed vs. immediate footshock0.30.41.20.10.1-0.3-0.1-0.30.50.10.91.11.1
Distance traveled before self-admin0.70.83.10.60.4-0.10.0-0.00.3-0.61.8-1.3-1.3
Distance traveled after self-admin0.80.95.20.60.6-0.6-0.1-0.50.3-0.62.3-1.0-1.1
Extensor digitorum longus weight2.811.222.73.12.7-2.82.01.74.5-0.64.14.54.8
Bone: elastic displacement1.01.22.70.80.9-0.81.31.00.9-1.60.3-1.4-1.3
Bone: elastic work0.70.93.1-0.9-0.81.0-0.2-0.3-0.6-0.3-0.9-1.8-1.5
Bone: endosteal estimation11.324.740.0-5.8-5.75.4-6.2-6.3-6.05.2-2.4-1.7-1.8
Bone: endosteal perimeter12.626.144.8-6.2-5.95.6-6.6-6.7-5.65.5-1.6-1.5-1.4
Epididymis fat weight0.71.72.5-1.6-1.61.5-1.6-1.4-0.51.5-0.11.11.3
Delta time in closed arm before/after self-admin0.40.42.0-0.3-0.1-0.00.0-0.2-0.4-0.4-0.3-1.3-1.4
Delta time in open arm before/after self-admin1.41.35.00.90.7-0.60.61.00.90.10.12.22.2
Diff in mean of infusions in LGA sessions0.70.81.41.11.0-1.01.00.81.2-0.60.80.50.6
Delay discount exponential model param0.20.20.50.70.6-0.60.50.60.3-0.40.2-0.1-0.1
Extinction: sum of active levers before priming0.60.62.4-0.2-0.20.1-0.5-0.6-0.11.1-0.11.61.4
Active lever presses in extinction session 62.22.13.6-1.5-1.71.9-1.8-1.7-1.61.7-0.5-0.4-0.6
Bone: final force1.62.65.2-1.8-1.61.8-1.1-1.0-1.50.6-1.5-2.3-2.0
Bone: final moment1.93.06.4-1.9-1.81.9-1.2-1.1-1.70.6-1.7-2.5-2.2
Food consumed during 24 hour testing period2.63.15.6-1.9-1.91.7-2.1-2.3-1.02.4-0.21.71.5
Glucose0.71.12.71.21.3-1.11.00.71.4-1.01.60.2-0.0
Heart weight0.20.31.80.10.10.0-0.2-0.30.60.11.30.80.4
Delay discount hyperbolic model param0.10.10.30.60.5-0.50.40.40.2-0.20.4-0.1-0.0
Intermittent access intake day 1-15 change0.30.31.1-0.3-0.30.3-0.6-1.0-0.20.40.9-0.0-0.4
Intermittent access intake escalation0.10.10.60.1-0.00.0-0.2-0.60.10.00.80.1-0.2
Intermittent access intake escalation 20.40.41.3-0.6-0.60.6-0.8-1.1-0.50.60.3-0.1-0.4
Intermitt. access day 1 inactive lever presses4.85.28.3-2.6-2.62.7-2.4-2.1-2.91.9-2.1-1.3-1.7
Intermitt. access day 15 inactive lever presses3.23.56.1-2.1-2.22.5-1.8-1.4-2.41.6-2.0-1.0-1.2
Intermitt. access escalation Index3.12.74.11.92.0-2.01.71.41.9-1.81.9-0.1-0.2
Intermittent access day 1 total infusions0.80.91.6-1.1-1.21.2-1.2-1.0-0.61.1-0.00.50.5
Intermittent access day 15 total infusions0.70.81.5-0.7-0.80.7-1.0-1.2-0.10.90.91.11.0
Intermittent access terminal intake (last 3 days)2.02.23.9-1.6-1.71.6-1.9-2.0-1.11.8-0.10.80.7
Intermittent access total infusions2.32.64.3-1.9-2.01.8-2.0-2.1-1.31.9-0.30.70.8
Intermittent access day 1 locomotion3.33.45.7-2.3-2.42.3-2.3-2.4-1.72.0-0.2-0.00.5
Intermittent access day 15 total locomotion4.04.37.9-2.6-2.62.3-2.6-2.8-1.82.3-0.40.40.8
Intermittent access total locomotion6.47.311.6-3.4-3.43.1-3.3-3.3-2.63.0-1.10.10.5
Intermittent access standard deviation1.41.42.5-1.4-1.51.5-1.4-1.6-1.21.2-0.7-0.0-0.3
Left kidney weight0.30.71.80.60.8-0.60.90.81.1-1.41.1-0.6-0.5
Right kidney weight0.10.31.0-0.00.1-0.10.50.20.4-0.90.1-1.0-1.0
Cocaine induced anxiety0.40.52.6-0.0-0.10.20.20.4-0.2-0.3-0.3-1.6-1.4
Post-drug Anxiety0.50.52.70.20.10.10.30.40.1-0.50.2-1.6-1.5
Baseline Anxiety0.60.61.10.90.9-0.80.90.80.9-1.00.7-0.0-0.0
Tail length2.06.09.6-3.1-3.02.8-2.9-2.7-2.62.8-1.90.30.2
Length with tail1.96.911.7-3.4-3.23.2-3.1-3.0-2.72.6-1.9-0.7-0.7
Length without tail0.61.22.2-1.2-1.11.3-0.9-0.9-1.10.3-1.1-1.5-1.2
Times rat made contact with spout0.60.72.0-1.0-1.00.8-1.0-1.4-0.90.9-0.2-0.4-0.2
Lifetime Intake2.83.24.9-2.1-2.22.2-2.2-2.0-1.72.2-1.00.50.5
Liver weight, left0.71.22.6-1.4-1.21.1-1.0-0.8-1.21.2-1.6-0.3-0.2
Liver weight, right0.30.51.10.00.2-0.10.81.10.6-1.0-0.9-0.7-0.8
Locomotor activity0.30.51.5-0.8-0.60.3-0.9-1.2-0.90.80.00.30.2
Locomotor testing distance1.01.73.8-1.4-1.20.9-1.7-1.9-1.61.7-0.10.30.5
Locomotor testing rearing0.71.13.4-0.9-0.70.3-1.3-1.8-1.41.40.60.30.4
Locomotion in novel chamber0.60.72.3-0.00.3-0.5-0.0-0.60.4-0.71.4-1.5-1.3
Locomotion in novel chamber post-restriction1.41.72.6-1.5-1.61.6-1.6-1.2-1.31.6-1.1-0.10.0
Fecal boli incidents, locomotor time 10.10.10.40.30.20.0-0.2-0.30.30.10.60.50.3
Change in fecal boli incidents, locomotor task0.30.30.70.30.4-0.40.40.30.8-0.60.70.50.5
Time >=10cm from walls, locomotor time 12.62.63.71.71.9-1.91.61.61.6-1.91.7-0.8-1.1
Bouts of movement, locomotor time 10.20.20.80.60.4-0.20.70.90.6-0.3-0.20.30.2
Total resting periods, locomotor time 10.20.30.90.60.4-0.20.70.90.7-0.5-0.30.10.1
Rest time, locomotor task time 10.30.31.20.30.3-0.10.50.8-0.3-0.4-1.1-0.5-0.8
Distance moved, locomotor task time 10.40.51.2-0.9-0.90.7-0.8-1.1-0.30.60.10.10.4
Vertical activity count, locomotor time 10.40.40.9-0.8-0.80.7-0.7-1.0-0.50.30.0-0.7-0.5
Time >=10cm from walls, locomotor time 20.80.84.40.10.3-0.30.20.1-0.2-0.60.4-1.8-2.1
Bouts of movement, locomotor time 20.20.20.50.70.3-0.10.40.70.5-0.30.40.40.2
Total resting periods, locomotor time 20.40.41.11.00.7-0.40.81.10.7-0.60.60.30.0
Rest time, locomotor task time 23.03.55.72.42.2-2.02.12.42.1-1.81.40.40.4
Distance moved, locomotor task time 20.80.91.4-1.1-1.00.9-0.7-1.2-0.90.5-0.8-1.1-1.1
Vertical activity count, locomotor time 23.43.75.7-2.1-2.22.1-1.9-2.0-2.41.7-2.0-1.0-1.2
Light reinforcement 10.61.23.8-0.5-0.81.0-0.50.3-0.41.2-2.01.51.3
Light reinforcement 21.01.36.5-0.9-1.21.4-0.70.2-1.10.9-2.50.20.4
Bone: marrow area11.124.139.2-5.7-5.65.3-6.1-6.3-5.95.1-2.3-1.7-1.9
Bone: maximum diameter5.410.015.3-3.8-3.73.9-3.6-3.2-3.52.6-2.1-2.3-2.1
Bone: maximum force2.03.55.9-2.4-2.22.4-1.9-1.7-1.81.4-1.5-1.4-1.4
Bone: maximum moment2.33.96.5-2.5-2.42.6-1.9-1.8-2.01.3-1.7-1.7-1.6
Mean time between licks in bursts0.30.41.80.1-0.10.1-0.4-0.60.60.31.30.70.9
Mean num. licks in bursts0.20.30.6-0.5-0.50.4-0.5-0.6-0.30.7-0.30.40.8
Cd content in liver4.44.99.02.52.6-3.02.31.92.5-1.92.11.41.2
Co content in liver1.01.22.31.31.1-1.40.70.51.3-0.51.50.91.1
Cu content in liver0.50.61.6-0.6-0.81.0-0.6-0.2-0.90.8-1.3-0.20.1
Fe content in liver0.30.31.00.80.7-0.60.71.0-0.1-0.4-0.50.10.0
K content in liver1.01.02.7-1.0-1.11.3-0.9-0.4-1.21.0-1.6-0.2-0.2
Mg content in liver0.60.63.8-0.1-0.20.30.10.8-0.30.7-1.90.70.8
Mn content in liver1.01.16.8-0.4-0.40.80.10.8-1.0-0.1-2.6-0.9-0.9
Na content in liver0.40.41.4-0.6-0.50.7-0.5-0.1-0.91.0-1.2-0.0-0.1
Rb content in liver2.32.96.52.12.0-1.92.22.51.4-1.8-0.2-0.00.2
Se content in liver1.51.82.81.61.5-1.51.31.71.5-1.10.91.01.1
Sr content in liver0.70.61.0-0.9-0.90.9-0.7-0.9-0.60.30.0-1.0-1.0
Zn content in liver0.10.10.4-0.4-0.40.3-0.20.2-0.20.2-0.6-0.6-0.1
Bone: minimum diameter11.220.931.5-5.6-5.55.4-5.6-5.6-4.84.9-2.2-1.5-1.2
Time in familiar zone, hab. session 10.90.82.8-0.4-0.30.2-0.8-1.00.11.10.71.71.3
Time in novel zone, hab. session 11.01.02.40.70.7-0.51.11.30.2-1.4-0.2-1.5-1.4
Total zone transitions, hab. session 10.20.20.8-0.6-0.40.3-0.4-0.80.10.30.20.90.4
Total locomotion distance, hab. session 11.11.63.0-1.7-1.51.5-1.0-1.0-1.30.6-1.7-0.6-1.2
Locomotion velocity, hab. session 11.31.93.6-1.9-1.61.6-1.2-1.3-1.40.8-1.7-0.3-0.9
Time in familiar zone, hab. session 20.90.92.2-0.6-0.50.1-1.1-1.5-0.21.41.00.91.1
Time in novel zone, hab. session 21.21.22.40.50.40.11.11.5-0.0-1.5-1.3-1.2-1.6
Total zone transitions, hab. session 20.20.21.2-0.00.0-0.1-0.1-0.30.30.30.11.10.8
Total locomotion distance, hab. session 20.50.72.2-0.7-0.70.7-0.4-0.4-0.50.8-1.51.20.7
Locomotion velocity, hab. session 20.50.62.0-0.7-0.70.6-0.4-0.4-0.30.7-1.41.20.8
Novel to familiar place preference ratio0.30.40.6-0.8-0.80.8-0.7-0.6-0.60.5-0.1-0.6-0.2
Novelty place preference0.20.20.4-0.5-0.50.5-0.4-0.3-0.40.3-0.1-0.6-0.4
Time in novel zone, NPP test0.20.20.8-0.4-0.40.4-0.3-0.2-0.40.1-0.1-0.9-0.6
Total zone transitions, NPP test0.10.20.9-0.3-0.20.2-0.0-0.0-0.1-0.0-0.90.80.3
Total locomotion distance, NPP test0.81.04.0-1.2-1.11.1-0.6-0.6-1.20.4-2.00.0-0.6
Locomotion velocity, NPP test0.50.72.5-0.9-1.00.9-0.6-0.5-0.60.6-1.60.90.3
Intraocular pressure0.81.11.8-0.9-1.01.0-1.2-1.0-0.11.30.71.31.3
Delta distance traveled before/after self-admin0.30.31.00.70.8-1.00.60.40.4-0.70.3-0.1-0.2
Delta ambulatory time before/after self-admin0.00.10.20.10.2-0.40.2-0.1-0.1-0.2-0.4-0.0-0.1
Parametrial fat weight1.63.05.9-2.1-2.12.3-1.5-1.2-1.71.4-2.4-0.9-1.0
Pavlov. Cond. lever latency3.13.95.82.02.2-2.41.81.82.3-1.22.31.61.8
Pavlov. Cond. magazine entry latency4.25.48.3-2.5-2.62.9-2.3-2.1-2.82.0-2.7-1.2-1.5
Pavlov. Cond. change in total contacts3.94.16.7-2.0-2.32.6-2.0-1.6-2.51.7-2.6-1.3-1.3
Pavlov. Cond. index score3.84.87.7-2.3-2.52.8-2.2-2.0-2.61.8-2.6-1.3-1.5
Pavlov. Cond. latency score3.03.86.0-2.0-2.22.4-2.0-1.9-2.21.6-2.2-1.1-1.3
Pavlov. Cond. lever contacts2.42.84.4-1.6-1.92.1-1.6-1.7-1.91.2-1.7-1.3-1.4
Pavlov. Cond. magazine entry number3.64.58.72.12.3-2.61.91.52.6-1.73.01.31.4
Pavlov. Cond. intertrial magazine entries1.11.34.3-0.5-0.70.6-1.1-1.0-0.21.30.21.92.1
Pavlov. Cond. lever-magazine prob. diff.3.74.67.7-2.2-2.42.8-2.1-1.9-2.51.6-2.4-1.4-1.6
Pavlov. Cond. response bias5.56.711.6-2.6-2.83.2-2.2-1.9-3.21.6-3.4-2.1-2.3
Pavlov. Cond. lever latency0.30.40.70.60.6-0.60.70.70.8-0.60.40.20.4
Pavlov. Cond. magazine entry latency2.22.53.71.91.9-1.91.71.31.8-1.81.8-0.1-0.0
Pavlov. Cond. change in total contacts0.20.20.6-0.3-0.30.1-0.6-0.7-0.50.80.10.50.6
Pavlov. Cond. index score0.10.10.40.20.3-0.30.0-0.2-0.0-0.30.6-0.5-0.5
Pavlov. Cond. latency score0.20.20.70.30.3-0.30.1-0.1-0.0-0.50.7-0.8-0.8
Pavlov. Cond. lever contacts0.20.20.5-0.5-0.50.5-0.6-0.5-0.70.5-0.5-0.1-0.3
Pavlov. Cond. magazine entry number2.73.35.0-2.1-2.22.2-2.0-1.6-1.92.2-1.90.40.4
Pavlov. Cond. intertrial magazine entries11.314.822.0-4.5-4.64.6-4.6-4.1-3.94.7-3.00.80.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.40.30.4-0.40.2-0.00.1-0.40.7-0.5-0.5
Pavlov. Cond. response bias0.00.00.00.00.0-0.1-0.0-0.1-0.1-0.10.1-0.1-0.2
Time in closed arm before self-admin0.80.91.61.01.0-0.91.21.00.4-1.30.2-1.0-0.8
Time in closed arm after self-admin1.21.22.21.01.1-1.41.10.60.5-1.50.8-1.4-1.1
Time in open arm before self-admin0.80.92.80.50.7-0.80.40.00.9-1.01.7-1.1-1.0
Time in open arm after self-admin0.60.72.5-0.0-0.20.4-0.6-0.40.50.71.01.61.5
Bone: periosteal estimation9.619.727.8-5.3-5.25.3-5.1-4.9-5.24.1-3.0-2.6-2.5
Bone: periosteal perimeter5.99.814.1-3.8-3.63.7-3.5-3.6-3.32.4-1.3-2.6-2.4
Bone: post-yield work1.82.55.9-1.9-1.81.7-2.1-2.4-1.41.60.2-0.6-0.6
Progressive ratio test 1 active lever presses3.73.96.2-2.3-2.52.4-2.5-2.2-2.02.3-1.10.10.4
Progressive ratio test 1 breakpoint4.85.07.9-2.6-2.82.7-2.8-2.5-2.32.7-1.20.40.6
Progressive ratio test 1 inactive lever presses3.84.16.3-2.4-2.52.4-2.5-2.2-2.22.4-1.40.30.4
Progressive ratio test 2 active lever presses4.44.87.6-2.7-2.82.6-2.7-2.5-2.12.5-1.2-0.00.5
Progressive ratio test 2 breakpoint5.25.89.1-2.9-3.02.9-3.0-2.9-2.42.8-0.9-0.20.3
Progressive ratio test 2 inactive lever presses4.04.67.3-2.6-2.72.6-2.5-2.3-1.92.6-1.40.81.0
Incentive Sensitization - Responses2.82.84.6-2.1-2.01.9-2.1-2.2-1.62.0-0.5-0.00.3
Incentive Sensitization - Breakpoint2.52.64.6-2.0-1.91.7-2.1-2.1-1.51.9-0.4-0.20.2
Sum of active levers in priming session hrs 5-60.60.61.90.80.7-0.70.40.60.50.40.31.41.3
Progressive ratio0.10.10.30.40.1-0.10.1-0.00.3-0.30.50.20.3
Food seeking constrained by brief footshock2.12.66.6-1.8-1.61.3-2.0-2.6-1.52.0-0.20.70.7
Seeking ratio, punishment vs. effort0.91.12.1-1.4-1.00.8-1.3-1.5-1.11.3-0.50.1-0.1
Retroperitoneal fat weight1.13.56.2-2.5-2.32.0-2.2-2.4-1.62.1-1.20.80.4
Reaction time number correct0.40.61.20.80.8-0.70.80.70.9-1.10.80.3-0.2
Reaction time mean minus median0.20.30.70.70.6-0.40.60.80.5-0.60.2-0.1-0.1
Reaction time mean minus median AUC0.91.22.81.31.2-1.11.41.71.0-1.30.2-0.1-0.0
Reaction time num false alarms2.73.65.8-2.3-2.22.1-2.4-2.4-2.02.2-0.8-0.4-0.5
Reaction time num false alarms AUC3.14.36.7-2.6-2.52.4-2.5-2.4-2.22.3-1.4-0.4-0.6
Reaction time trials correct on left0.40.61.20.80.8-0.70.80.70.9-1.10.80.3-0.2
Reaction time trials on left0.40.51.20.80.7-0.60.80.70.8-1.10.80.2-0.3
Reaction time mean0.81.22.51.11.1-0.91.31.60.3-1.2-0.6-1.0-1.0
Reaction time mean AUC1.01.43.21.41.3-1.11.51.80.4-1.3-0.5-0.9-0.9
Median of all reaction times0.91.22.51.11.1-0.91.31.60.2-1.2-0.8-1.1-1.1
Reaction time omissions0.40.61.7-0.3-0.30.60.10.4-0.8-0.3-1.3-1.1-1.3
Reaction time false alarm rate3.14.36.3-2.5-2.42.3-2.5-2.4-2.32.4-1.4-0.7-0.6
Reaction time premature initiation rate0.70.91.6-1.1-1.21.0-1.2-1.0-1.01.3-0.50.10.7
Reaction time premature initiations0.30.40.6-0.7-0.70.6-0.7-0.6-0.40.7-0.10.40.8
Std. dev. reaction times0.40.51.40.80.7-0.50.91.20.3-0.8-0.4-0.5-0.5
Reaction time trials completed0.40.51.20.80.7-0.60.80.70.8-1.10.80.2-0.3
Reaction time trials AUC0.40.61.20.80.8-0.70.80.70.9-1.10.80.4-0.2
Run reversals in cocaine runway, females0.20.20.70.10.10.10.30.20.5-0.60.5-0.4-0.8
Run reversals in cocaine runway, males0.20.20.90.20.2-0.00.10.30.2-0.50.5-0.8-1.0
Latency to leave start box in cocaine runway0.30.30.50.70.7-0.70.60.50.5-0.70.5-0.5-0.4
Latency to leave start box in cocaine runway, F0.80.91.70.90.9-0.70.70.60.8-1.21.1-1.3-1.2
Latency to leave start box in cocaine runway, M0.20.20.60.10.3-0.40.20.2-0.10.2-0.40.70.8
Std. dev. time between licks in bursts0.10.20.70.20.10.00.00.20.20.20.20.80.7
Total sessions with >9 infusions0.30.41.1-0.4-0.50.5-0.4-0.3-0.20.6-0.41.01.0
Short access day 1 total inactive lever presses1.01.11.7-1.3-1.21.2-1.1-1.2-1.20.8-0.4-0.9-1.0
Short access day 10 total inactive lever presses0.70.81.5-0.8-1.01.2-0.9-0.7-0.81.0-0.80.90.0
Short access day 1 total infusions1.01.11.8-1.1-1.11.1-1.1-0.9-0.71.3-0.61.11.1
Short access day 10 total infusions5.15.79.0-2.7-2.93.0-2.9-2.7-2.42.9-1.40.60.3
Short access total infusions2.93.35.0-2.0-2.22.2-2.2-1.9-1.92.2-1.20.30.2
Short access day 1 locomotion3.13.35.5-2.1-2.22.1-2.2-1.9-1.42.3-0.60.91.2
Short access day 10 total locomotion8.39.314.8-3.7-3.73.5-3.8-3.9-2.93.7-1.20.70.9
Short access total locomotion4.34.47.1-2.4-2.62.4-2.7-2.6-1.92.6-0.50.70.9
One hour access (0.3 mA shock)0.81.01.9-1.0-1.11.1-1.3-1.4-0.91.20.20.10.2
Compulsive drug intake1.21.22.30.81.0-1.01.00.80.8-1.40.8-1.5-1.4
One hour access (shock baseline)1.31.52.5-1.1-1.31.3-1.4-1.4-0.91.6-0.31.21.1
Social response proportion0.50.63.20.60.5-0.50.20.01.0-0.51.80.50.3
Social responses0.10.10.4-0.2-0.10.0-0.3-0.50.10.40.60.40.4
Social time0.30.42.0-0.0-0.20.2-0.6-0.9-0.1-0.11.4-0.6-0.5
Soleus weight0.20.51.4-0.7-0.80.8-0.8-1.2-0.30.60.5-0.7-0.4
Bone: stiffness0.50.81.5-1.2-1.11.0-1.1-1.0-0.81.0-0.6-0.1-0.0
Tibialis anterior weight0.62.28.5-0.0-0.30.2-0.7-0.61.21.41.52.62.9
Time to tail flick, vehicle, before self-admin0.80.83.70.00.2-0.00.1-0.0-0.0-0.90.5-1.9-1.8
Time to tail flick, vehicle, after self-admin0.70.71.3-0.8-1.11.1-1.0-0.5-0.71.0-0.90.60.5
Time to tail flick, test, before self-admin0.70.71.80.90.9-1.00.80.40.9-1.01.4-0.1-0.1
Time to tail flick, test, after self-admin0.10.10.30.1-0.10.20.20.30.0-0.4-0.2-0.5-0.4
Delta time to tail flick, vehicle, before/after SA2.52.54.7-1.5-1.71.7-1.4-0.8-1.52.0-2.21.41.2
Delta time to tail flick, test, before/after SA0.20.10.9-0.2-0.30.4-0.10.3-0.30.2-0.90.20.2
Tibia length0.20.51.9-0.7-0.40.4-0.0-0.2-0.2-0.5-0.3-1.4-1.4
Ambulatory time before self-admin0.60.63.10.30.2-0.0-0.2-0.30.2-0.41.8-1.1-1.2
Ambulatory time after self-admin0.50.62.00.00.1-0.1-0.4-0.8-0.3-0.31.2-1.2-1.4
Bone: tissue strength0.90.91.71.01.1-1.01.10.91.0-1.30.6-0.1-0.1
Total heroin consumption0.81.02.1-0.7-0.70.8-0.8-0.7-1.40.5-0.9-1.5-1.4
Bone: trabecular number4.06.312.3-2.9-2.62.8-1.8-1.3-3.11.3-3.5-2.5-2.4
Bone: trabecular spacing2.12.86.31.81.6-1.80.90.31.9-0.42.52.02.0
Bone: trabecular thickness5.56.611.3-2.9-2.93.4-2.0-1.4-2.81.4-3.1-2.6-2.4
Bone: trabecular tissue density0.60.92.40.80.8-0.71.21.50.9-1.5-0.3-0.3-0.3
Water consumed over 24 hours0.10.10.3-0.5-0.50.4-0.2-0.4-0.30.2-0.5-0.2-0.1
Number of responses in last shaping day1.11.21.9-1.1-1.31.4-1.3-1.3-1.00.80.1-1.0-0.9