Hub : Genes

Abtb2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Abtb2 0.04 0.03 1.1e-05 0.04 0.05 0.05 0.05 8.8e-05 6.5e-06 3.8e-06 4.8e-06
2 pVTA gene expression Abtb2 0.31 0.19 7.2e-11 0.24 0.25 0.25 0.24 8.0e-11 2.7e-11 3.8e-11 8.6e-11
3 Brain gene expression Abtb2 0.19 0.12 1.1e-15 0.16 0.08 0.16 0.04 8.3e-15 5.2e-08 7.8e-15 1.6e-04
4 LHb gene expression Abtb2 0.13 0.11 3.6e-03 0.04 0.07 0.05 0.04 4.2e-02 8.3e-03 2.2e-02 4.5e-02
5 Liver gene expression Abtb2 0.2 0.12 0.0e+00 0.19 0.19 0.18 0.19 1.7e-20 1.4e-20 1.0e-19 2.2e-20
6 Eye gene expression Abtb2 0.31 0.21 3.8e-03 0.18 0.16 0.14 0.16 1.1e-03 2.1e-03 3.4e-03 1.7e-03
7 BLA gene expression Abtb2 0.07 0.06 7.1e-04 0.01 0.01 -0 0 5.9e-02 8.8e-02 5.9e-01 1.8e-01
8 OFC gene expression Abtb2 0.16 0.12 1.3e-03 0.14 0.12 0.13 0.13 3.4e-04 1.0e-03 4.8e-04 6.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.61.01.21.1-1.11.0-1.01.0-0.91.00.6
Area under the delay curve0.20.20.6-0.50.2-0.40.3-0.40.0-0.3-0.8
BMI with tail0.10.40.60.5-0.50.7-0.50.5-0.80.80.2
BMI without tail0.51.01.80.9-0.91.0-0.90.9-1.21.31.0
Body weight0.72.84.41.7-1.41.6-1.51.5-1.62.11.8
Weight adjusted by age2.52.94.0-2.01.6-1.61.7-1.71.6-1.8-1.6
Bone surface0.61.11.51.1-1.11.0-1.01.0-1.01.20.6
Bone volume1.42.33.11.7-1.71.6-1.61.6-1.51.41.0
Breakpoint value in progressive ratio session1.21.32.1-1.51.4-1.31.3-1.21.0-0.8-0.5
Number of licking bursts0.30.30.50.6-0.70.5-0.60.6-0.70.40.2
Context. condit. distance diff. score3.44.26.52.1-1.91.8-2.02.0-2.01.82.5
Locomotion velocity, session 10.10.10.3-0.30.2-0.20.2-0.30.4-0.6-0.1
Locomotion distance, session 10.00.00.3-0.0-0.00.10.0-0.00.1-0.3-0.5
Locomotion velocity, session 20.00.00.1-0.1-0.0-0.10.0-0.0-0.00.3-0.0
Locomotion distance, session 20.20.30.40.6-0.50.6-0.50.5-0.50.50.3
Locomotion velocity, session 30.10.10.10.3-0.30.3-0.20.2-0.20.0-0.4
Locomotion distance, session 30.20.20.30.6-0.50.5-0.50.5-0.40.10.3
Stereotopy head waving bouts, day 30.10.10.8-0.20.2-0.10.2-0.20.3-0.3-0.9
Stereotopy head waving duration, day 30.40.50.90.7-0.80.7-0.70.7-0.70.90.3
Locomotion velocity, session 70.10.10.50.10.10.1-0.00.10.00.10.7
Locomotion distance, session 70.40.50.8-0.70.9-0.70.8-0.70.8-0.70.0
Stereotopy head waving bouts, day 70.10.10.10.2-0.30.3-0.30.3-0.30.3-0.2
Stereotopy head waving duration, day 70.00.10.20.1-0.20.2-0.20.2-0.20.5-0.2
Locomotion velocity, session 80.50.61.40.9-0.60.7-0.70.7-0.60.41.2
Locomotion distance, session 83.34.96.32.5-2.12.1-2.12.2-2.22.12.5
Degree of sensitization distance0.40.40.6-0.70.8-0.70.7-0.60.6-0.30.3
Degree of sensitization stereotypy0.00.00.1-0.0-0.10.1-0.10.0-0.10.3-0.3
Conditioned locomotion3.84.45.8-2.42.0-2.12.1-2.12.0-1.9-2.3
Cocaine response after cond. corrected2.62.93.5-1.81.7-1.61.7-1.71.8-1.3-1.9
Cocaine response after cond. not corrected0.40.50.7-0.80.7-0.70.7-0.70.7-0.1-0.9
Cocaine response before conditioning6.47.89.22.9-2.82.6-2.72.7-2.93.02.6
Saline control response0.70.91.11.0-1.11.0-1.01.0-1.01.10.5
Bone: connectivity density0.61.01.51.0-1.00.9-1.01.0-1.11.20.6
Bone: cortical apparent density0.10.10.3-0.30.6-0.40.4-0.40.4-0.10.3
Bone: cortical area0.40.62.70.6-0.30.4-0.50.5-0.50.91.6
Bone: cortical porosity0.50.50.9-0.70.6-0.70.7-0.70.6-0.9-0.7
Bone: cortical porosity0.20.20.3-0.50.4-0.40.4-0.50.4-0.6-0.2
Bone: cortical thickness0.10.21.30.10.1-0.0-0.00.1-0.20.61.1
Bone: cortical thickness3.13.65.1-2.32.0-2.12.0-2.01.8-1.5-1.3
Bone: cortical tissue density0.10.10.2-0.20.5-0.30.3-0.30.30.00.4
Condit. Reinf. active minus inactive responses1.41.62.01.4-1.41.2-1.31.3-1.41.10.9
Condit. Reinf. active-inactive response ratio3.13.43.92.0-2.01.8-1.91.9-2.01.61.5
Condit. Reinf. active responses0.50.60.80.9-0.90.7-0.80.8-0.80.70.4
Condit. Reinf. inactive responses0.50.50.8-0.70.8-0.80.7-0.70.9-0.4-0.7
Incentive salience index mean1.41.72.01.4-1.41.2-1.31.3-1.41.21.0
Condit. Reinf. lever presses1.11.41.71.3-1.21.1-1.21.2-1.31.21.0
Condit. Reinf. active minus inactive responses1.72.12.91.4-1.41.3-1.31.3-1.51.71.6
Condit. Reinf. active-inactive response ratio4.74.96.62.2-2.11.9-2.12.1-2.22.62.5
Condit. Reinf. active responses1.01.42.01.2-1.21.1-1.11.1-1.21.41.2
Condit. Reinf. inactive responses0.00.10.3-0.10.1-0.00.1-0.10.1-0.3-0.5
Condit. Reinf. lever presses0.71.01.30.9-1.00.9-0.90.9-1.01.11.1
Condit. Reinf. lever reinforcers received0.91.31.61.2-1.21.1-1.11.1-1.21.31.1
Conditioned reinforcement - actives4.54.56.12.3-1.71.8-1.91.9-2.42.52.4
Conditioned reinforcement - inactives9.110.313.43.7-3.33.1-3.23.2-3.23.22.8
Conditioned locomotion2.02.43.81.9-1.51.8-1.61.6-1.51.40.9
Patch foraging indifference point 0 sec0.60.93.1-0.90.5-0.60.6-0.70.8-1.2-1.7
Patch foraging indifference point AUC1.31.52.3-1.41.5-1.41.4-1.31.1-0.6-0.7
Delay disc. indifference point, 0s delay0.00.00.10.1-0.0-0.1-0.00.0-0.30.10.1
Delay disc. indifference point, 16s delay1.41.42.2-1.51.2-1.31.3-1.30.7-0.9-1.1
Delay disc. indifference point, 2s delay0.10.20.3-0.60.4-0.50.4-0.40.0-0.1-0.2
Delay disc. indifference point, 24s delay0.20.20.5-0.50.3-0.40.4-0.40.1-0.5-0.7
Delay disc. indifference point, 4s delay0.10.10.2-0.40.2-0.40.3-0.40.2-0.3-0.5
Delay disc. indifference point, 8s delay0.30.30.50.6-0.70.5-0.60.5-0.70.5-0.1
Indifference point function ln k0.91.21.71.3-1.31.3-1.21.2-1.00.70.7
Indifference point function log k0.91.21.71.3-1.31.3-1.21.2-1.00.70.7
Patch foraging total patch changes 0 sec0.50.83.1-0.80.3-0.50.5-0.60.7-1.1-1.8
Patch foraging total patch changes 12 sec0.00.00.10.1-0.10.1-0.10.1-0.10.3-0.0
Patch foraging total patch changes 18 sec0.50.61.1-0.80.8-0.90.8-0.80.5-0.4-1.1
Patch foraging total patch changes 24 sec1.31.63.1-1.51.1-1.21.2-1.20.9-1.0-1.8
Patch foraging total patch changes 6 sec0.40.61.3-1.00.7-0.70.7-0.70.5-0.7-1.2
Patch foraging time to switch 0 sec0.00.00.1-0.30.2-0.20.2-0.2-0.0-0.2-0.0
Patch foraging water rate 0 sec0.00.00.20.0-0.20.1-0.10.10.00.2-0.4
Patch foraging water rate 12 sec0.10.10.2-0.40.3-0.40.3-0.30.30.20.0
Patch foraging water rate 18 sec0.81.11.51.1-1.11.1-1.11.1-0.91.20.9
Patch foraging water rate 24 sec0.10.10.4-0.20.1-0.30.1-0.1-0.20.30.6
Patch foraging water rate 6 sec0.00.00.0-0.0-0.10.0-0.10.1-0.0-0.0-0.1
Seeking ratio, delayed vs. immediate footshock0.20.30.60.6-0.50.4-0.50.5-0.80.40.6
Distance traveled before self-admin0.60.61.00.8-0.70.9-0.80.8-0.70.61.0
Distance traveled after self-admin0.80.92.40.9-0.60.8-0.80.8-1.01.01.5
Extensor digitorum longus weight0.31.11.3-1.21.1-1.11.1-1.11.1-0.7-0.7
Bone: elastic displacement1.51.72.5-1.61.4-1.51.4-1.41.3-1.0-0.4
Bone: elastic work1.21.62.3-1.51.4-1.31.3-1.31.2-1.1-0.5
Bone: endosteal estimation0.20.40.8-0.60.5-0.50.5-0.60.9-0.8-0.6
Bone: endosteal perimeter0.30.60.80.9-0.80.8-0.80.8-0.60.40.8
Epididymis fat weight0.82.02.71.6-1.51.5-1.41.4-1.31.21.2
Delta time in closed arm before/after self-admin0.10.10.40.00.3-0.00.2-0.10.6-0.5-0.1
Delta time in open arm before/after self-admin0.30.31.0-0.50.1-0.40.3-0.30.3-0.5-1.0
Diff in mean of infusions in LGA sessions0.20.20.3-0.60.5-0.60.5-0.50.3-0.10.3
Delay discount exponential model param0.20.20.70.6-0.30.4-0.40.5-0.10.40.8
Extinction: sum of active levers before priming0.10.10.50.30.00.4-0.20.30.20.20.7
Active lever presses in extinction session 60.20.10.30.4-0.30.5-0.40.4-0.10.30.6
Bone: final force0.10.10.70.00.1-0.10.0-0.00.20.10.8
Bone: final moment0.10.20.3-0.40.5-0.40.4-0.40.6-0.20.5
Food consumed during 24 hour testing period7.59.111.33.4-2.93.0-3.03.0-2.93.03.1
Glucose2.33.44.92.0-1.71.7-1.81.8-1.71.92.2
Heart weight0.30.40.9-0.80.4-0.60.5-0.60.8-1.0-0.1
Delay discount hyperbolic model param0.10.20.50.5-0.20.4-0.30.4-0.10.30.7
Intermittent access intake day 1-15 change0.20.20.50.4-0.50.4-0.40.4-0.70.40.2
Intermittent access intake escalation0.50.50.90.7-0.80.7-0.70.7-0.90.70.5
Intermittent access intake escalation 23.03.03.51.9-1.81.7-1.71.7-1.91.71.5
Intermitt. access day 1 inactive lever presses0.10.10.60.10.2-0.10.1-0.10.4-0.10.8
Intermitt. access day 15 inactive lever presses3.03.34.92.2-1.71.9-1.81.8-1.41.61.9
Intermitt. access escalation Index0.70.61.50.5-0.60.3-0.50.5-1.21.00.9
Intermittent access day 1 total infusions3.54.05.32.3-2.02.0-2.02.0-2.12.01.5
Intermittent access day 15 total infusions5.25.87.42.6-2.42.4-2.42.4-2.72.42.0
Intermittent access terminal intake (last 3 days)7.27.99.53.0-2.82.7-2.72.7-3.12.92.3
Intermittent access total infusions7.17.99.33.1-2.82.7-2.82.8-3.02.92.3
Intermittent access day 1 locomotion1.41.52.21.5-1.21.3-1.21.2-1.31.20.6
Intermittent access day 15 total locomotion1.51.62.71.6-1.41.6-1.41.3-1.20.90.0
Intermittent access total locomotion2.02.33.41.8-1.71.8-1.61.6-1.31.20.6
Intermittent access standard deviation6.16.48.02.8-2.62.7-2.62.6-2.42.42.1
Left kidney weight0.61.73.41.5-1.01.4-1.21.2-0.71.41.8
Right kidney weight0.41.21.91.3-0.81.3-1.01.0-0.71.01.4
Cocaine induced anxiety0.40.41.20.7-0.50.5-0.60.6-0.30.51.1
Post-drug Anxiety0.00.00.10.00.1-0.00.00.00.10.00.3
Baseline Anxiety2.83.04.5-1.91.6-1.61.7-1.71.5-1.6-2.1
Tail length0.61.84.21.3-0.91.0-1.11.1-1.21.72.1
Length with tail0.62.34.11.6-1.21.3-1.31.3-1.31.92.0
Length without tail0.30.70.90.9-0.80.8-0.80.8-0.50.80.9
Times rat made contact with spout0.10.10.20.4-0.40.4-0.40.4-0.40.20.3
Lifetime Intake7.38.310.13.2-2.92.8-2.92.9-3.02.92.5
Liver weight, left0.40.61.80.6-0.50.5-0.60.6-0.61.21.3
Liver weight, right1.52.55.21.6-1.31.4-1.41.5-1.31.72.3
Locomotor activity0.00.10.20.1-0.40.3-0.30.3-0.10.1-0.1
Locomotor testing distance1.22.02.31.4-1.51.4-1.41.4-1.31.51.2
Locomotor testing rearing0.10.20.30.3-0.50.4-0.50.4-0.50.60.4
Locomotion in novel chamber0.50.60.80.9-0.90.8-0.80.8-0.80.70.1
Locomotion in novel chamber post-restriction1.01.21.6-1.31.0-1.11.0-1.01.1-1.0-1.1
Fecal boli incidents, locomotor time 16.97.510.3-3.23.0-3.12.9-2.92.4-2.3-1.9
Change in fecal boli incidents, locomotor task5.55.27.72.8-2.52.6-2.42.4-2.02.01.2
Time >=10cm from walls, locomotor time 10.10.10.2-0.30.4-0.50.3-0.3-0.10.10.1
Bouts of movement, locomotor time 10.50.51.0-0.90.9-1.00.9-0.80.2-0.3-0.1
Total resting periods, locomotor time 10.40.40.8-0.80.8-0.90.8-0.80.2-0.20.1
Rest time, locomotor task time 10.30.30.5-0.60.7-0.70.6-0.60.20.10.5
Distance moved, locomotor task time 11.71.92.91.7-1.51.5-1.51.5-1.01.11.1
Vertical activity count, locomotor time 10.10.10.20.4-0.40.4-0.40.40.0-0.0-0.0
Time >=10cm from walls, locomotor time 26.87.28.93.0-2.62.5-2.62.6-2.72.72.7
Bouts of movement, locomotor time 20.20.20.4-0.50.5-0.30.4-0.40.6-0.60.2
Total resting periods, locomotor time 20.10.10.3-0.40.4-0.20.3-0.30.5-0.40.2
Rest time, locomotor task time 21.92.22.9-1.71.5-1.51.5-1.51.4-1.3-1.4
Distance moved, locomotor task time 24.65.46.82.6-2.32.2-2.32.3-2.02.42.6
Vertical activity count, locomotor time 22.42.63.51.9-1.61.6-1.61.6-1.21.51.9
Light reinforcement 10.10.20.80.4-0.20.3-0.30.3-0.20.60.9
Light reinforcement 20.10.10.90.10.10.1-0.10.10.10.20.9
Bone: marrow area0.20.40.9-0.60.5-0.60.6-0.60.9-0.8-0.6
Bone: maximum diameter0.30.62.10.7-0.50.6-0.60.6-0.50.51.5
Bone: maximum force0.00.10.30.3-0.20.2-0.20.2-0.10.30.6
Bone: maximum moment0.00.10.1-0.20.3-0.20.2-0.20.4-0.10.1
Mean time between licks in bursts1.11.52.8-1.31.1-1.11.1-1.11.2-1.2-1.7
Mean num. licks in bursts0.00.00.0-0.10.2-0.00.1-0.10.2-0.10.1
Cd content in liver1.11.21.61.2-1.21.1-1.11.1-1.20.90.8
Co content in liver1.31.52.1-1.41.1-1.31.2-1.21.1-1.0-1.4
Cu content in liver0.30.30.5-0.70.6-0.60.6-0.60.5-0.4-0.5
Fe content in liver0.50.61.1-1.10.7-0.90.8-0.80.7-0.6-0.7
K content in liver2.82.83.4-1.71.7-1.51.6-1.61.8-1.8-1.6
Mg content in liver1.91.92.5-1.61.4-1.41.4-1.41.4-1.2-1.2
Mn content in liver1.92.12.8-1.71.5-1.51.5-1.51.6-1.4-0.9
Na content in liver0.10.10.1-0.20.3-0.30.2-0.20.30.10.3
Rb content in liver1.31.62.1-1.51.4-1.41.3-1.31.4-1.0-0.9
Se content in liver3.74.56.2-2.51.9-2.12.0-2.11.9-1.9-2.5
Sr content in liver0.10.10.1-0.40.3-0.30.3-0.30.3-0.3-0.2
Zn content in liver0.10.10.1-0.40.4-0.40.4-0.40.3-0.3-0.3
Bone: minimum diameter0.91.73.51.3-1.01.1-1.11.2-1.01.41.9
Time in familiar zone, hab. session 10.70.70.8-0.80.9-0.80.8-0.80.9-0.9-0.7
Time in novel zone, hab. session 11.31.31.61.1-1.31.2-1.21.1-1.11.11.1
Total zone transitions, hab. session 12.02.83.81.9-1.81.9-1.81.7-1.81.31.0
Total locomotion distance, hab. session 10.60.91.41.2-1.11.1-1.01.0-1.00.3-0.3
Locomotion velocity, hab. session 10.40.60.80.9-0.90.9-0.80.8-0.70.1-0.6
Time in familiar zone, hab. session 20.10.10.70.10.00.10.0-0.00.1-0.6-0.8
Time in novel zone, hab. session 20.30.31.50.1-0.20.1-0.20.2-0.30.91.2
Total zone transitions, hab. session 21.72.33.01.7-1.41.5-1.41.5-1.41.51.5
Total locomotion distance, hab. session 20.00.00.10.10.10.10.0-0.00.1-0.3-0.3
Locomotion velocity, hab. session 20.00.10.20.00.10.10.1-0.10.2-0.4-0.5
Novel to familiar place preference ratio0.70.71.11.1-0.91.0-0.90.9-0.80.50.5
Novelty place preference0.70.71.11.1-0.91.0-0.90.9-0.90.50.5
Time in novel zone, NPP test0.50.50.70.9-0.80.8-0.70.7-0.70.40.5
Total zone transitions, NPP test0.50.81.4-1.00.7-0.90.8-0.80.7-0.9-1.2
Total locomotion distance, NPP test0.60.81.8-0.90.7-0.80.8-0.80.8-1.1-1.3
Locomotion velocity, NPP test0.50.71.7-0.80.7-0.60.7-0.70.7-1.0-1.3
Intraocular pressure0.00.10.3-0.1-0.20.1-0.00.0-0.2-0.5-0.4
Delta distance traveled before/after self-admin0.10.20.3-0.30.6-0.50.5-0.4-0.10.00.3
Delta ambulatory time before/after self-admin0.10.10.3-0.10.4-0.30.3-0.2-0.10.10.5
Parametrial fat weight0.91.72.71.3-1.21.2-1.21.2-1.61.61.0
Pavlov. Cond. lever latency0.50.60.8-0.90.8-0.70.8-0.80.8-0.7-0.6
Pavlov. Cond. magazine entry latency0.91.22.01.3-0.91.1-1.01.1-1.01.01.4
Pavlov. Cond. change in total contacts0.20.30.5-0.50.5-0.40.4-0.50.5-0.7-0.5
Pavlov. Cond. index score0.20.30.50.7-0.50.6-0.60.6-0.50.40.6
Pavlov. Cond. latency score0.20.30.50.7-0.50.6-0.60.6-0.50.40.6
Pavlov. Cond. lever contacts0.30.40.50.7-0.60.6-0.70.7-0.60.60.6
Pavlov. Cond. magazine entry number0.91.11.7-1.20.9-1.01.0-1.00.9-1.0-1.3
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.2-0.0-0.20.1-0.10.1-0.2-0.3
Pavlov. Cond. lever-magazine prob. diff.0.20.20.40.6-0.40.5-0.50.5-0.50.30.4
Pavlov. Cond. response bias0.91.01.61.1-0.90.9-1.01.0-0.91.11.3
Pavlov. Cond. lever latency2.33.13.5-1.91.9-1.71.8-1.71.9-1.6-1.7
Pavlov. Cond. magazine entry latency0.80.91.21.1-1.11.0-1.01.0-1.10.60.7
Pavlov. Cond. change in total contacts1.11.51.81.3-1.31.2-1.21.2-1.31.21.0
Pavlov. Cond. index score2.02.53.11.7-1.71.6-1.61.6-1.71.31.3
Pavlov. Cond. latency score2.53.13.71.9-1.91.8-1.81.8-1.91.51.4
Pavlov. Cond. lever contacts2.73.64.42.0-2.11.8-1.91.9-2.11.71.7
Pavlov. Cond. magazine entry number0.40.50.7-0.80.8-0.80.8-0.70.8-0.3-0.5
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.20.3-0.30.2-0.20.2-0.00.1
Pavlov. Cond. lever-magazine prob. diff.1.72.22.71.6-1.61.5-1.51.5-1.61.31.3
Pavlov. Cond. response bias1.92.63.01.7-1.71.5-1.61.6-1.71.31.6
Time in closed arm before self-admin2.42.74.21.4-1.51.1-1.41.4-2.01.92.0
Time in closed arm after self-admin0.80.81.40.9-0.80.7-0.80.8-0.90.91.2
Time in open arm before self-admin1.82.03.2-1.41.3-1.11.3-1.31.5-1.4-1.8
Time in open arm after self-admin2.62.95.4-1.81.4-1.41.5-1.51.7-1.8-2.3
Bone: periosteal estimation0.00.10.3-0.10.2-0.10.1-0.10.30.00.5
Bone: periosteal perimeter1.22.03.21.6-1.21.4-1.31.4-1.31.31.8
Bone: post-yield work0.10.10.5-0.1-0.1-0.0-0.0-0.0-0.0-0.3-0.7
Progressive ratio test 1 active lever presses3.94.05.32.3-2.01.9-2.02.0-1.92.01.9
Progressive ratio test 1 breakpoint3.63.84.92.2-1.91.9-1.92.0-1.91.91.9
Progressive ratio test 1 inactive lever presses2.02.23.11.7-1.41.5-1.51.5-1.21.41.8
Progressive ratio test 2 active lever presses3.03.24.12.0-1.71.8-1.71.8-1.91.81.7
Progressive ratio test 2 breakpoint3.74.15.22.3-1.91.9-2.02.0-2.12.02.0
Progressive ratio test 2 inactive lever presses3.94.56.22.5-2.12.1-2.12.1-1.82.02.1
Incentive Sensitization - Responses1.41.42.01.3-1.01.1-1.11.1-1.41.21.2
Incentive Sensitization - Breakpoint1.11.11.61.2-1.01.0-1.01.0-1.31.01.0
Sum of active levers in priming session hrs 5-60.90.81.4-1.01.2-0.80.9-0.91.1-0.90.0
Progressive ratio0.40.51.00.9-0.60.8-0.70.7-0.20.41.0
Food seeking constrained by brief footshock1.01.21.71.3-1.11.1-1.11.1-1.01.10.8
Seeking ratio, punishment vs. effort0.20.31.1-0.60.3-0.50.4-0.40.1-0.4-1.0
Retroperitoneal fat weight8.929.136.56.0-5.65.6-5.55.5-5.05.14.6
Reaction time number correct0.00.10.3-0.0-0.20.0-0.10.1-0.40.60.2
Reaction time mean minus median0.10.20.30.4-0.30.5-0.40.4-0.20.40.5
Reaction time mean minus median AUC0.10.20.20.4-0.30.5-0.40.4-0.30.40.5
Reaction time num false alarms1.52.02.7-1.51.3-1.31.3-1.31.5-1.4-1.6
Reaction time num false alarms AUC2.02.73.5-1.91.5-1.61.6-1.61.8-1.5-1.7
Reaction time trials correct on left0.00.10.3-0.0-0.20.0-0.10.1-0.40.60.2
Reaction time trials on left0.00.00.2-0.2-0.0-0.10.0-0.0-0.30.50.1
Reaction time mean0.30.40.90.7-0.40.5-0.50.5-0.60.71.0
Reaction time mean AUC0.50.61.40.9-0.60.6-0.60.7-0.70.81.2
Median of all reaction times0.60.81.71.0-0.60.7-0.70.7-0.91.01.3
Reaction time omissions1.21.61.9-1.41.3-1.21.3-1.31.2-1.4-1.1
Reaction time false alarm rate2.73.84.6-2.01.8-1.71.8-1.82.1-2.0-2.1
Reaction time premature initiation rate0.10.20.3-0.50.5-0.50.5-0.40.3-0.50.1
Reaction time premature initiations0.10.10.2-0.50.4-0.50.4-0.40.1-0.10.2
Std. dev. reaction times0.00.00.20.2-0.00.1-0.10.10.00.10.5
Reaction time trials completed0.00.00.2-0.2-0.0-0.10.0-0.0-0.30.50.1
Reaction time trials AUC0.10.10.50.1-0.30.1-0.20.2-0.50.70.3
Run reversals in cocaine runway, females0.20.20.50.3-0.20.4-0.30.3-0.40.50.7
Run reversals in cocaine runway, males5.55.36.6-2.62.3-2.22.3-2.32.6-2.2-2.0
Latency to leave start box in cocaine runway0.50.51.4-0.40.4-0.30.4-0.41.1-1.2-0.8
Latency to leave start box in cocaine runway, F0.40.51.6-0.30.3-0.10.3-0.31.0-1.3-0.9
Latency to leave start box in cocaine runway, M0.20.20.2-0.30.5-0.50.4-0.40.4-0.5-0.2
Std. dev. time between licks in bursts0.30.40.6-0.80.5-0.70.6-0.60.5-0.6-0.3
Total sessions with >9 infusions2.52.73.21.8-1.61.5-1.61.6-1.81.81.6
Short access day 1 total inactive lever presses0.80.91.21.1-1.10.9-1.01.0-0.80.90.6
Short access day 10 total inactive lever presses0.20.21.00.6-0.20.4-0.30.40.30.01.0
Short access day 1 total infusions9.710.413.03.6-3.23.0-3.23.2-3.13.33.1
Short access day 10 total infusions3.84.25.02.2-2.22.1-2.12.1-2.22.01.3
Short access total infusions5.86.67.72.8-2.62.5-2.52.5-2.72.72.2
Short access day 1 locomotion3.84.15.52.3-2.22.1-2.12.1-1.82.01.2
Short access day 10 total locomotion2.93.25.02.2-1.92.2-1.91.9-1.31.41.2
Short access total locomotion3.23.34.62.1-2.02.0-1.91.9-1.61.71.2
One hour access (0.3 mA shock)3.13.65.22.3-1.82.1-1.91.9-1.81.71.6
Compulsive drug intake2.02.02.6-1.51.5-1.31.4-1.41.6-1.4-1.0
One hour access (shock baseline)6.57.69.33.0-2.82.8-2.82.8-2.92.72.2
Social response proportion4.34.76.3-2.52.3-2.32.3-2.22.1-1.8-1.6
Social responses0.00.10.20.3-0.10.2-0.20.2-0.10.10.5
Social time2.33.14.2-2.01.7-1.81.8-1.81.5-1.5-1.9
Soleus weight1.85.25.8-2.42.3-2.22.2-2.22.3-2.3-2.3
Bone: stiffness0.40.71.01.0-0.70.8-0.80.8-0.70.61.0
Tibialis anterior weight2.79.412.3-3.53.2-3.23.2-3.13.1-2.5-2.5
Time to tail flick, vehicle, before self-admin3.43.55.42.3-2.02.1-2.02.0-1.61.51.2
Time to tail flick, vehicle, after self-admin5.15.47.12.7-2.42.3-2.32.3-2.32.31.9
Time to tail flick, test, before self-admin1.41.41.81.3-1.31.2-1.31.2-0.91.01.1
Time to tail flick, test, after self-admin2.32.43.21.8-1.81.6-1.71.7-1.31.30.8
Delta time to tail flick, vehicle, before/after SA0.10.10.20.2-0.30.1-0.20.2-0.40.50.3
Delta time to tail flick, test, before/after SA0.10.10.30.2-0.20.2-0.10.1-0.40.2-0.6
Tibia length0.10.40.7-0.60.7-0.70.6-0.60.70.10.9
Ambulatory time before self-admin0.50.51.00.6-0.50.6-0.60.6-0.90.71.0
Ambulatory time after self-admin1.31.44.41.1-0.70.9-0.90.9-1.21.22.1
Bone: tissue strength0.20.20.6-0.30.2-0.10.2-0.20.4-0.8-0.7
Total heroin consumption1.21.42.1-1.41.4-1.21.3-1.21.1-1.0-0.8
Bone: trabecular number0.50.81.10.9-1.00.8-0.90.9-0.91.00.6
Bone: trabecular spacing0.10.20.30.6-0.30.5-0.40.4-0.40.30.5
Bone: trabecular thickness0.20.20.30.5-0.50.5-0.50.5-0.50.50.3
Bone: trabecular tissue density1.42.02.8-1.41.4-1.21.3-1.31.4-1.7-1.4
Water consumed over 24 hours0.20.30.60.5-0.50.4-0.50.5-0.50.40.8
Number of responses in last shaping day2.02.02.81.4-1.31.2-1.31.4-1.51.61.7