Best TWAS P=1.104088e-08 · Best GWAS P=5.75313e-09 conditioned to 1
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | Casp8 | gene expression | ENSRNOG00000012331 | 0.09 | 0.01 | enet | 11 | 0.02 | 1.5e-03 | -4.7 | -5.5 | 4.2e-08 | 0.82 | 0.19 | 0.69 | FALSE |
2 | Adipose | Kctd18 | gene expression | ENSRNOG00000027091 | 0.08 | 0.03 | enet | 488 | 0.04 | 1.9e-05 | -4.8 | 5.7 | 1.1e-08 | -0.33 | 0.85 | 0.14 | TRUE |
3 | Adipose | Aox2 | gene expression | ENSRNOG00000033923 | 0.05 | 0.01 | blup | 2414 | 0.03 | 8.6e-04 | -3.8 | -5.3 | 1.0e-07 | 0.86 | 0.64 | 0.34 | FALSE |
4 | BLA | Kctd18 | intron excision ratio | chr9:59515068:59515815 | 0.08 | 0.06 | top1 | 1 | 0.06 | 3.9e-04 | -5.4 | 5.4 | 6.3e-08 | -0.96 | 0.11 | 0.09 | FALSE |
5 | BLA | Kctd18 | intron excision ratio | chr9:59515068:59516751 | 0.11 | 0.08 | lasso | 10 | 0.08 | 3.9e-05 | -5.1 | -5.5 | 4.3e-08 | 0.80 | 0.54 | 0.45 | FALSE |
6 | BLA | Aox1 | mRNA stability | ENSRNOG00000015354 | 0.10 | 0.06 | enet | 12 | 0.07 | 1.7e-04 | -5.2 | -5.4 | 6.9e-08 | 0.78 | 0.72 | 0.25 | FALSE |
7 | Brain | Nif3l1 | gene expression | ENSRNOG00000013446 | 0.05 | 0.03 | top1 | 1 | 0.03 | 7.9e-04 | -5.6 | 5.6 | 2.1e-08 | -0.94 | 0.06 | 0.43 | TRUE |
8 | LHb | Kctd18 | intron excision ratio | chr9:59510430:59512513 | 0.14 | 0.06 | lasso | 3 | 0.11 | 1.8e-03 | -4.6 | -5.2 | 2.2e-07 | 0.79 | 0.38 | 0.31 | FALSE |
9 | Liver | Kctd18 | gene expression | ENSRNOG00000027091 | 0.04 | 0.01 | enet | 157 | 0.02 | 1.0e-03 | -4.8 | 5.5 | 4.2e-08 | -0.91 | 0.48 | 0.45 | FALSE |
10 | NAcc | Maip1 | gene expression | ENSRNOG00000015983 | 0.06 | 0.04 | lasso | 35 | 0.05 | 1.7e-04 | -3.8 | 5.1 | 3.2e-07 | -0.88 | 0.31 | 0.67 | TRUE |
11 | NAcc | Kctd18 | intron excision ratio | chr9:59515068:59515815 | 0.10 | 0.08 | lasso | 16 | 0.08 | 1.0e-06 | -5.3 | 5.4 | 7.1e-08 | -0.91 | 0.66 | 0.34 | FALSE |
12 | OFC | Aox4 | gene expression | ENSRNOG00000014555 | 0.39 | 0.21 | blup | 2460 | 0.25 | 1.5e-06 | -4.8 | 5.4 | 8.0e-08 | -0.81 | 0.63 | 0.36 | TRUE |
13 | PL | Kctd18 | intron excision ratio | chr9:59515068:59516751 | 0.06 | 0.02 | blup | 2551 | 0.04 | 6.7e-04 | -4.7 | -5.5 | 3.9e-08 | 0.89 | 0.51 | 0.46 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.