Best TWAS P=8.14e-13 · Best GWAS P=4.98e-13 conditioned to NaN
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Lancl1 | alternative polyA | NM_053723.1 | 0.08 | 2363 | 0.02 | 4.0e-03 | 5.3 | 1.17e-07 | 0.24 | TRUE |
| Adipose | Lancl1 | alternative polyA | XM_039082904.1 | 0.08 | 2363 | 0.02 | 4.3e-03 | -5.23 | 1.69e-07 | 0.24 | FALSE |
| Adipose | Kansl1l | alternative TSS | XM_039084605.1 | 0.03 | 85 | 0 | 2.4e-01 | -5.72 | 1.05e-08 | 0.14 | FALSE |
| Adipose | Kansl1l | alternative TSS | XM_039084606.1 | 0.11 | 1 | 0.05 | 3.7e-06 | -5.67 | 1.40e-08 | 0.02 | FALSE |
| Adipose | Kansl1l | alternative TSS | XM_039084605.1 | 0.03 | 89 | 0 | 8.1e-02 | -5.75 | 8.80e-09 | 0.12 | FALSE |
| Adipose | Kansl1l | alternative TSS | XM_039084606.1 | 0.1 | 2491 | 0.02 | 1.3e-03 | 6.12 | 9.50e-10 | 0.33 | FALSE |
| Adipose | Kansl1l | alternative TSS | XM_039084608.1 | 0.08 | 1 | 0 | 2.2e-01 | 6.6 | 4.06e-11 | 0.03 | FALSE |
| Adipose | Unc80 | gene expression | Unc80 | 0.31 | 179 | 0.19 | 7.0e-21 | 5.23 | 1.71e-07 | 0 | FALSE |
| Adipose | Kansl1l | isoform ratio | XM_039084605.1 | 0.03 | 120 | 0 | 1.2e-01 | -5.26 | 1.44e-07 | 0.11 | FALSE |
| Adipose | Kansl1l | isoform ratio | XM_039084606.1 | 0.12 | 1 | 0.05 | 2.3e-06 | -5.67 | 1.40e-08 | 0.01 | FALSE |
| Adipose | Lancl1 | isoform ratio | NM_053723.1 | 0.11 | 2363 | 0.03 | 1.7e-04 | 5.44 | 5.33e-08 | 0.31 | FALSE |
| Adipose | Kansl1l | intron excision ratio | chr9_68300220_68306570 | 0.15 | 1 | 0.05 | 1.2e-06 | 5.72 | 1.06e-08 | 0.01 | FALSE |
| BLA | Map2 | alternative polyA | NM_013066.1 | 0.12 | 1 | 0.07 | 7.7e-05 | 5.69 | 1.24e-08 | 0.03 | FALSE |
| BLA | Map2 | alternative polyA | XM_017596293.2 | 0.17 | 1 | 0.12 | 9.1e-07 | -5.69 | 1.24e-08 | 0.01 | FALSE |
| BLA | Lancl1 | gene expression | Lancl1 | 0.35 | 3 | 0.29 | 4.0e-16 | 5.79 | 6.97e-09 | 0.35 | FALSE |
| BLA | Map2 | mRNA stability | Map2 | 0.39 | 94 | 0.26 | 2.5e-14 | -5.81 | 6.34e-09 | 0.86 | FALSE |
| Brain | Map2 | alternative polyA | NM_013066.1 | 0.56 | 31 | 0.37 | 1.1e-35 | -7.03 | 2.12e-12 | 0.93 | FALSE |
| Brain | Map2 | alternative polyA | XM_017596293.2 | 0.56 | 19 | 0.36 | 7.3e-35 | 6.97 | 3.23e-12 | 0.93 | FALSE |
| Brain | Lancl1 | gene expression | Lancl1 | 0.27 | 25 | 0.47 | 1.3e-48 | 5.59 | 2.28e-08 | 0 | FALSE |
| Brain | Map2 | gene expression | Map2 | 0.47 | 52 | 0.34 | 4.1e-33 | -5.36 | 8.29e-08 | 0 | TRUE |
| Brain | Rpe | gene expression | Rpe | 0.03 | 38 | 0.02 | 1.0e-02 | -6 | 2.03e-09 | 0.08 | FALSE |
| Brain | Kansl1l | isoform ratio | XM_039084628.1 | 0.03 | 2491 | 0.02 | 9.7e-03 | -5.6 | 2.13e-08 | 0.05 | FALSE |
| Brain | Lancl1 | isoform ratio | XM_039082905.1 | 0.03 | 9 | 0.01 | 1.4e-02 | -5.72 | 1.04e-08 | 0.26 | FALSE |
| Brain | Map2 | isoform ratio | XM_008767208.3 | 0.49 | 79 | 0.27 | 5.6e-25 | -6.23 | 4.62e-10 | 0.9 | FALSE |
| Brain | Lancl1 | mRNA stability | Lancl1 | 0.09 | 3 | 0.07 | 9.7e-07 | 5.81 | 6.19e-09 | 0 | FALSE |
| Eye | Map2 | intron excision ratio | chr9_67853512_67853774 | 0.38 | 2607 | 0.12 | 6.6e-03 | -5.34 | 9.22e-08 | 0.12 | FALSE |
| IL | Map2 | gene expression | Map2 | 0.22 | 2607 | 0.12 | 8.7e-04 | 5.81 | 6.32e-09 | 0.75 | FALSE |
| IL | Lancl1 | isoform ratio | NM_053723.1 | 0.21 | 1 | 0.2 | 1.9e-05 | -5.61 | 2.00e-08 | 0.05 | FALSE |
| IL | Kansl1l | mRNA stability | Kansl1l | 0.35 | 2491 | 0.07 | 8.1e-03 | -5.29 | 1.22e-07 | 0.17 | FALSE |
| LHb | Kansl1l | mRNA stability | Kansl1l | 0.27 | 20 | 0.08 | 5.1e-03 | -5.64 | 1.68e-08 | 0.15 | TRUE |
| Liver | Lancl1 | alternative polyA | NM_053723.1 | 0.39 | 1 | 0.21 | 3.7e-23 | -5.58 | 2.38e-08 | 0 | FALSE |
| Liver | Lancl1 | alternative polyA | XM_039082904.1 | 0.38 | 1 | 0.21 | 7.2e-23 | 5.58 | 2.38e-08 | 0 | FALSE |
| Liver | Lancl1 | alternative TSS | NM_053723.1 | 0.04 | 1 | 0 | 1.6e-01 | 5.67 | 1.39e-08 | 0.03 | FALSE |
| Liver | Lancl1 | alternative TSS | XM_039082904.1 | 0.04 | 2363 | 0.01 | 2.1e-02 | 5.32 | 1.06e-07 | 0.16 | FALSE |
| Liver | Lancl1 | gene expression | Lancl1 | 0.59 | 37 | 0.33 | 2.1e-37 | 5.66 | 1.53e-08 | 0 | FALSE |
| Liver | Lancl1 | isoform ratio | NM_053723.1 | 0.34 | 1 | 0.21 | 8.3e-23 | -5.58 | 2.38e-08 | 0 | FALSE |
| Liver | Lancl1 | mRNA stability | Lancl1 | 0.06 | 1 | 0.03 | 6.3e-04 | -5.72 | 1.06e-08 | 0.03 | FALSE |
| NAcc | Map2 | alternative polyA | XM_017596293.2 | 0.07 | 1 | 0.04 | 1.0e-05 | -7.16 | 8.14e-13 | 0.9 | TRUE |
| NAcc | Lancl1 | isoform ratio | XM_039082905.1 | 0.02 | 1 | 0.03 | 3.3e-04 | 5.48 | 4.22e-08 | 0.03 | TRUE |
| NAcc | Kansl1l | mRNA stability | Kansl1l | 0.04 | 1 | 0.02 | 1.5e-03 | 5.72 | 1.06e-08 | 0.03 | FALSE |
| PL | Lancl1 | gene expression | Lancl1 | 0.28 | 6 | 0.26 | 6.4e-29 | 5.27 | 1.35e-07 | 0 | FALSE |
| PL | Map2 | isoform ratio | XM_008767208.3 | 0.04 | 2607 | 0.01 | 3.4e-02 | 6.11 | 9.71e-10 | 0.63 | FALSE |
| PL | Rpe | intron excision ratio | chr9_68197390_68201755 | 0.08 | 35 | 0.05 | 3.6e-06 | 5.56 | 2.68e-08 | 0.02 | FALSE |
| pVTA | Kansl1l | alternative TSS | XM_039084612.1 | 0.16 | 29 | 0.08 | 2.9e-04 | 6.35 | 2.21e-10 | 0.3 | FALSE |
| pVTA | Acadl | gene expression | Acadl | 0.22 | 1 | 0.23 | 1.7e-10 | -5.68 | 1.32e-08 | 0 | FALSE |
| pVTA | Unc80 | mRNA stability | Unc80 | 0.06 | 2425 | 0.04 | 1.2e-02 | 5.31 | 1.08e-07 | 0.23 | FALSE |