Best TWAS P=4.49e-23 · Best GWAS P=5.05e-25 conditioned to NaN
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Elk3 | gene expression | ENSRNOG00000004367 | 0.11 | 2579 | 0.05 | 2.5e-06 | 7.52 | 5.62e-14 | 0.28 | FALSE |
| Adipose | Hal | gene expression | ENSRNOG00000004502 | 0.03 | 2432 | 0.01 | 6.9e-02 | -7.84 | 4.56e-15 | 0.33 | TRUE |
| Adipose | Vezt | gene expression | ENSRNOG00000006514 | 0.11 | 1 | 0.08 | 3.2e-09 | -6.97 | 3.12e-12 | 0 | FALSE |
| Adipose | Ndufa12 | gene expression | ENSRNOG00000007407 | 0.34 | 16 | 0.2 | 1.0e-21 | -7.08 | 1.41e-12 | 0 | FALSE |
| Adipose | Cep83 | intron excision ratio | chr7:29322957:29325469 | 0.03 | 2703 | 0.02 | 1.8e-03 | -7.55 | 4.34e-14 | 0.34 | FALSE |
| Adipose | Nedd1 | mRNA stability | ENSRNOG00000004011 | 0.07 | 2860 | 0.05 | 1.4e-06 | -5.23 | 1.71e-07 | 0.48 | FALSE |
| Adipose | Vezt | mRNA stability | ENSRNOG00000006514 | 0.07 | 2570 | 0.06 | 5.0e-07 | -8.25 | 1.60e-16 | 0.28 | FALSE |
| BLA | AABR07056633.1 | alternative polyA | ENSRNOT00000104436 | 0.08 | 2953 | 0.02 | 2.7e-02 | -6.92 | 4.52e-12 | 0.06 | FALSE |
| BLA | AABR07056633.1 | alternative TSS | ENSRNOT00000094647 | 0.19 | 27 | 0.12 | 3.4e-07 | 5.22 | 1.76e-07 | 0 | FALSE |
| BLA | Cdk17 | gene expression | ENSRNOG00000004148 | 0.11 | 7 | 0.05 | 7.6e-04 | -5.64 | 1.72e-08 | 0.46 | FALSE |
| BLA | Ntn4 | gene expression | ENSRNOG00000005573 | 0.06 | 2475 | 0.03 | 8.1e-03 | 6.87 | 6.62e-12 | 0.37 | FALSE |
| BLA | Vezt | gene expression | ENSRNOG00000006514 | 0.32 | 97 | 0.3 | 1.1e-16 | -7.47 | 7.80e-14 | 0.57 | FALSE |
| BLA | Plxnc1 | gene expression | ENSRNOG00000007970 | 0.17 | 3125 | 0.11 | 2.6e-06 | -6.26 | 3.94e-10 | 0.01 | FALSE |
| BLA | Nudt4 | gene expression | ENSRNOG00000009094 | 0.46 | 64 | 0.38 | 1.9e-21 | 6.89 | 5.55e-12 | 0 | FALSE |
| BLA | Metap2 | gene expression | ENSRNOG00000021881 | 0.08 | 1 | 0.07 | 1.9e-04 | 8.51 | 1.77e-17 | 0.3 | FALSE |
| BLA | Mir331 | gene expression | ENSRNOG00000035543 | 0.06 | 2366 | 0.06 | 5.1e-04 | 8.56 | 1.10e-17 | 0.35 | FALSE |
| BLA | Fgd6 | gene expression | ENSRNOG00000054515 | 0.11 | 1 | 0.13 | 2.7e-07 | -7.74 | 9.85e-15 | 0.09 | FALSE |
| BLA | Tmcc3 | isoform ratio | ENSRNOT00000102476 | 0.1 | 2424 | 0.04 | 3.2e-03 | -7.88 | 3.31e-15 | 0.42 | TRUE |
| BLA | Socs2 | isoform ratio | ENSRNOT00000011948 | 0.06 | 1 | 0.05 | 1.2e-03 | 5.63 | 1.84e-08 | 0.04 | FALSE |
| BLA | Socs2 | isoform ratio | ENSRNOT00000103867 | 0.06 | 1 | 0.04 | 4.9e-03 | -5.63 | 1.84e-08 | 0.04 | FALSE |
| BLA | AABR07056633.1 | isoform ratio | ENSRNOT00000114083 | 0.18 | 1 | 0.06 | 6.5e-04 | -6.18 | 6.35e-10 | 0.04 | FALSE |
| BLA | Lta4h | intron excision ratio | chr7:27997602:27999743 | 0.07 | 2332 | 0.02 | 2.6e-02 | -7.2 | 6.09e-13 | 0.3 | FALSE |
| BLA | Vezt | intron excision ratio | chr7:28557619:28560958 | 0.07 | 2571 | 0.01 | 6.6e-02 | 7.21 | 5.80e-13 | 0.2 | FALSE |
| BLA | Tmcc3 | intron excision ratio | chr7:29100427:29159418 | 0.12 | 10 | 0.11 | 1.0e-06 | 6.63 | 3.32e-11 | 0.26 | FALSE |
| BLA | Tmcc3 | intron excision ratio | chr7:29133627:29159418 | 0.07 | 2424 | 0.04 | 4.3e-03 | -7.67 | 1.68e-14 | 0.41 | FALSE |
| BLA | Vezt | mRNA stability | ENSRNOG00000006514 | 0.4 | 1 | 0.42 | 4.0e-24 | 7.95 | 1.88e-15 | 0.35 | FALSE |
| BLA | Plxnc1 | mRNA stability | ENSRNOG00000007970 | 0.11 | 1 | 0.11 | 3.0e-06 | 9.16 | 5.04e-20 | 0.03 | FALSE |
| Brain | AABR07056633.1 | alternative TSS | ENSRNOT00000094647 | 0.06 | 1 | 0.02 | 3.3e-03 | 5.78 | 7.58e-09 | 0.03 | FALSE |
| Brain | AABR07056633.1 | alternative TSS | ENSRNOT00000094647 | 0.06 | 1 | 0.02 | 4.8e-03 | 5.78 | 7.58e-09 | 0.03 | FALSE |
| Brain | Cdk17 | gene expression | ENSRNOG00000004148 | 0.12 | 78 | 0.07 | 1.8e-07 | 6.4 | 1.60e-10 | 0 | FALSE |
| Brain | Lta4h | gene expression | ENSRNOG00000004494 | 0.05 | 1 | 0.04 | 9.1e-05 | 7.95 | 1.84e-15 | 0.05 | FALSE |
| Brain | Vezt | gene expression | ENSRNOG00000006514 | 0.24 | 2571 | 0.23 | 1.2e-20 | -8.04 | 9.22e-16 | 0.54 | FALSE |
| Brain | Ndufa12 | gene expression | ENSRNOG00000007407 | 0.49 | 2574 | 0.34 | 6.1e-32 | -7.22 | 5.13e-13 | 0 | TRUE |
| Brain | Plxnc1 | gene expression | ENSRNOG00000007970 | 0.05 | 3131 | 0.04 | 6.3e-05 | -6.1 | 1.09e-09 | 0.18 | FALSE |
| Brain | Socs2 | gene expression | ENSRNOG00000008965 | 0.22 | 118 | 0.11 | 5.0e-10 | 8.27 | 1.29e-16 | 0.78 | FALSE |
| Brain | Nudt4 | gene expression | ENSRNOG00000009094 | 0.86 | 57 | 0.74 | 8.6e-100 | 7.05 | 1.76e-12 | 0 | FALSE |
| Brain | Metap2 | gene expression | ENSRNOG00000021881 | 0.04 | 2312 | 0.01 | 1.4e-02 | 5.99 | 2.14e-09 | 0.39 | FALSE |
| Brain | Fgd6 | gene expression | ENSRNOG00000054515 | 0.16 | 1 | 0.23 | 8.6e-21 | -8.04 | 8.72e-16 | 0.54 | FALSE |
| Brain | Tmcc3 | isoform ratio | ENSRNOT00000102476 | 0.03 | 2424 | 0.01 | 3.4e-02 | -6.34 | 2.25e-10 | 0.04 | FALSE |
| Brain | AABR07056633.1 | isoform ratio | ENSRNOT00000094647 | 0.03 | 2953 | 0.01 | 7.7e-02 | 5.39 | 6.86e-08 | 0.09 | FALSE |
| Brain | Lta4h | intron excision ratio | chr7:27997602:27999743 | 0.04 | 1 | 0.02 | 4.8e-03 | -7.02 | 2.27e-12 | 0.03 | TRUE |
| Brain | Tmcc3 | intron excision ratio | chr7:29133627:29159418 | 0.05 | 2424 | 0.02 | 7.7e-03 | -5.84 | 5.07e-09 | 0.03 | FALSE |
| Brain | Lta4h | mRNA stability | ENSRNOG00000004494 | 0.05 | 2332 | 0.03 | 9.8e-04 | 7.43 | 1.10e-13 | 0.58 | FALSE |
| Brain | Vezt | mRNA stability | ENSRNOG00000006514 | 0.2 | 28 | 0.2 | 1.6e-18 | 8.13 | 4.26e-16 | 0.55 | FALSE |
| Brain | Ndufa12 | mRNA stability | ENSRNOG00000007407 | 0.03 | 1 | 0.02 | 4.2e-03 | 5.21 | 1.93e-07 | 0.03 | TRUE |
| Eye | Lta4h | gene expression | ENSRNOG00000004494 | 0.41 | 24 | 0.07 | 3.0e-02 | 7.39 | 1.44e-13 | 0.41 | FALSE |
| Eye | Nudt4 | gene expression | ENSRNOG00000009094 | 0.69 | 1 | 0.26 | 5.7e-05 | 6.12 | 9.25e-10 | 0.05 | FALSE |
| Eye | Fgd6 | gene expression | ENSRNOG00000054515 | 0.52 | 2560 | 0.15 | 2.3e-03 | -8.2 | 2.44e-16 | 0.19 | FALSE |
| Eye | Elk3 | isoform ratio | ENSRNOT00000005911 | 0.36 | 2579 | 0.1 | 1.2e-02 | -8.81 | 1.27e-18 | 0.45 | FALSE |
| IL | Vezt | gene expression | ENSRNOG00000006514 | 0.29 | 4 | 0.26 | 7.2e-07 | -8.2 | 2.45e-16 | 0.52 | FALSE |
| IL | Nudt4 | gene expression | ENSRNOG00000009094 | 0.62 | 2748 | 0.41 | 5.1e-11 | 5.62 | 1.90e-08 | 0 | FALSE |
| IL | Vezt | mRNA stability | ENSRNOG00000006514 | 0.23 | 2568 | 0.1 | 2.4e-03 | 8.18 | 2.86e-16 | 0.32 | FALSE |
| LHb | Nr2c1 | alternative polyA | ENSRNOT00000009578 | 0.2 | 1 | 0.19 | 2.6e-05 | 6.67 | 2.56e-11 | 0.05 | FALSE |
| LHb | Nr2c1 | alternative polyA | ENSRNOT00000089228 | 0.32 | 1 | 0.21 | 8.9e-06 | -6.67 | 2.56e-11 | 0.05 | FALSE |
| LHb | Ntn4 | gene expression | ENSRNOG00000005573 | 0.21 | 2473 | 0.06 | 1.6e-02 | -7.02 | 2.26e-12 | 0.48 | FALSE |
| LHb | Plxnc1 | gene expression | ENSRNOG00000007970 | 0.41 | 3118 | 0.22 | 7.2e-06 | -7.98 | 1.46e-15 | 0.27 | FALSE |
| LHb | Nudt4 | gene expression | ENSRNOG00000009094 | 0.75 | 1 | 0.3 | 6.1e-08 | 5.79 | 6.93e-09 | 0.03 | FALSE |
| LHb | Cdk17 | isoform ratio | ENSRNOT00000109496 | 0.18 | 2984 | 0.11 | 1.4e-03 | 7.07 | 1.58e-12 | 0.26 | FALSE |
| LHb | Vezt | mRNA stability | ENSRNOG00000006514 | 0.4 | 84 | 0.21 | 1.1e-05 | 8.35 | 6.75e-17 | 0.59 | FALSE |
| Liver | Nedd1 | gene expression | ENSRNOG00000004011 | 0.2 | 1 | 0.24 | 8.6e-27 | -6.19 | 5.99e-10 | 0.43 | FALSE |
| Liver | Hal | gene expression | ENSRNOG00000004502 | 0.15 | 17 | 0.1 | 6.5e-11 | 6.38 | 1.83e-10 | 0.14 | FALSE |
| Liver | Amdhd1 | gene expression | ENSRNOG00000005266 | 0.37 | 40 | 0.34 | 1.7e-39 | -7.75 | 8.92e-15 | 0 | FALSE |
| Liver | Ntn4 | gene expression | ENSRNOG00000005573 | 0.1 | 2475 | 0.06 | 4.3e-07 | -8.15 | 3.77e-16 | 0.52 | TRUE |
| Liver | Vezt | gene expression | ENSRNOG00000006514 | 0.14 | 322 | 0.14 | 1.7e-15 | -6.32 | 2.70e-10 | 0 | FALSE |
| Liver | Nr2c1 | gene expression | ENSRNOG00000006983 | 0.04 | 37 | 0.03 | 2.0e-04 | -6.46 | 1.05e-10 | 0.06 | FALSE |
| Liver | Ndufa12 | gene expression | ENSRNOG00000007407 | 0.42 | 320 | 0.46 | 1.8e-56 | -7.17 | 7.42e-13 | 0 | FALSE |
| Liver | Nudt4 | gene expression | ENSRNOG00000009094 | 0.1 | 21 | 0.06 | 4.1e-07 | -5.56 | 2.71e-08 | 0 | FALSE |
| Liver | Ccdc38 | gene expression | ENSRNOG00000021892 | 0.32 | 1 | 0.35 | 1.8e-40 | 6.75 | 1.51e-11 | 0 | FALSE |
| Liver | Ube2n | gene expression | ENSRNOG00000058053 | 0.03 | 7 | 0.02 | 1.1e-03 | -6.57 | 4.94e-11 | 0.01 | FALSE |
| Liver | Mrpl42 | intron excision ratio | chr7:30140191:30141604 | 0.03 | 32 | 0.02 | 2.2e-03 | 6.66 | 2.72e-11 | 0.06 | FALSE |
| Liver | Lta4h | mRNA stability | ENSRNOG00000004494 | 0.11 | 1 | 0.11 | 6.2e-12 | 7.94 | 1.95e-15 | 0.32 | FALSE |
| Liver | Amdhd1 | mRNA stability | ENSRNOG00000005266 | 0.24 | 1 | 0.22 | 6.1e-24 | -6.75 | 1.51e-11 | 0 | FALSE |
| Liver | Snrpf | mRNA stability | ENSRNOG00000005556 | 0.03 | 1 | 0.02 | 1.4e-03 | -6.92 | 4.45e-12 | 0.03 | FALSE |
| Liver | Socs2 | mRNA stability | ENSRNOG00000008965 | 0.04 | 3463 | 0.02 | 5.8e-03 | -7.71 | 1.26e-14 | 0.02 | FALSE |
| NAcc | AABR07056633.1 | alternative TSS | ENSRNOT00000094647 | 0.04 | 1 | 0.04 | 8.1e-04 | 5.88 | 4.18e-09 | 0.03 | FALSE |
| NAcc | AABR07056633.1 | alternative TSS | ENSRNOT00000104436 | 0.04 | 2952 | 0.03 | 1.5e-03 | -6.97 | 3.21e-12 | 0.04 | FALSE |
| NAcc | AABR07056633.1 | alternative TSS | ENSRNOT00000094647 | 0.05 | 1 | 0.04 | 6.8e-04 | 5.88 | 4.18e-09 | 0.03 | FALSE |
| NAcc | AABR07056633.1 | alternative TSS | ENSRNOT00000104436 | 0.05 | 2952 | 0.04 | 1.1e-03 | -6.66 | 2.70e-11 | 0.02 | FALSE |
| NAcc | Elk3 | gene expression | ENSRNOG00000004367 | 0.04 | 2578 | 0.02 | 1.6e-02 | 8.08 | 6.55e-16 | 0.24 | FALSE |
| NAcc | Lta4h | gene expression | ENSRNOG00000004494 | 0.04 | 1 | 0.05 | 8.4e-05 | 8.32 | 8.63e-17 | 0.38 | FALSE |
| NAcc | Vezt | gene expression | ENSRNOG00000006514 | 0.1 | 2569 | 0.14 | 1.4e-10 | -7.83 | 4.70e-15 | 0.11 | FALSE |
| NAcc | Cep83 | gene expression | ENSRNOG00000007859 | 0.06 | 1 | 0.05 | 7.5e-05 | 5.11 | 3.15e-07 | 0.03 | FALSE |
| NAcc | Plxnc1 | gene expression | ENSRNOG00000007970 | 0.12 | 6 | 0.13 | 1.0e-09 | -7.88 | 3.29e-15 | 0.07 | FALSE |
| NAcc | Nudt4 | gene expression | ENSRNOG00000009094 | 0.47 | 1 | 0.46 | 5.8e-38 | 6.1 | 1.04e-09 | 0 | FALSE |
| NAcc | Tmcc3 | isoform ratio | ENSRNOT00000102476 | 0.05 | 2420 | 0.04 | 8.4e-04 | -6.75 | 1.51e-11 | 0.27 | FALSE |
| NAcc | Vezt | intron excision ratio | chr7:28538513:28538938 | 0.05 | 2569 | 0.02 | 1.9e-02 | -5.94 | 2.77e-09 | 0.19 | FALSE |
| NAcc | Tmcc3 | intron excision ratio | chr7:29133627:29159418 | 0.05 | 2420 | 0.05 | 1.4e-04 | -7.73 | 1.06e-14 | 0.39 | FALSE |
| NAcc | Lta4h | mRNA stability | ENSRNOG00000004494 | 0.06 | 7 | 0.06 | 3.2e-05 | 7.69 | 1.50e-14 | 0.63 | FALSE |
| NAcc | Vezt | mRNA stability | ENSRNOG00000006514 | 0.14 | 10 | 0.11 | 1.5e-08 | 7.85 | 4.27e-15 | 0.48 | FALSE |
| OFC | Socs2 | alternative polyA | ENSRNOT00000011948 | 0.45 | 2973 | 0.09 | 3.7e-03 | 5.45 | 4.90e-08 | 0.03 | FALSE |
| OFC | Socs2 | alternative polyA | ENSRNOT00000103867 | 0.46 | 2973 | 0.09 | 4.0e-03 | -5.42 | 6.06e-08 | 0.03 | FALSE |
| OFC | Vezt | gene expression | ENSRNOG00000006514 | 0.38 | 117 | 0.28 | 3.0e-07 | -8.16 | 3.27e-16 | 0.63 | FALSE |
| OFC | Ndufa12 | gene expression | ENSRNOG00000007407 | 0.19 | 1 | 0.16 | 1.1e-04 | -8.24 | 1.68e-16 | 0.22 | FALSE |
| OFC | Nudt4 | gene expression | ENSRNOG00000009094 | 0.86 | 1 | 0.41 | 7.9e-11 | 5.79 | 6.93e-09 | 0.01 | FALSE |
| OFC | Socs2 | isoform ratio | ENSRNOT00000103867 | 0.33 | 1 | 0.15 | 2.3e-04 | -6.65 | 2.91e-11 | 0.05 | FALSE |
| OFC | Vezt | mRNA stability | ENSRNOG00000006514 | 0.24 | 2568 | 0.14 | 3.2e-04 | 8.47 | 2.36e-17 | 0.56 | FALSE |
| PL | Socs2 | alternative polyA | ENSRNOT00000011948 | 0.1 | 1 | 0.05 | 1.5e-04 | 7.24 | 4.64e-13 | 0.01 | FALSE |
| PL | Socs2 | alternative polyA | ENSRNOT00000103867 | 0.09 | 16 | 0.04 | 2.5e-04 | -7.14 | 9.48e-13 | 0 | FALSE |
| PL | AABR07056633.1 | alternative TSS | ENSRNOT00000094647 | 0.09 | 1 | 0.06 | 2.6e-05 | 5.91 | 3.45e-09 | 0 | FALSE |
| PL | AABR07056633.1 | alternative TSS | ENSRNOT00000104436 | 0.09 | 1 | 0.06 | 2.2e-05 | -5.91 | 3.45e-09 | 0 | FALSE |
| PL | AABR07056633.1 | alternative TSS | ENSRNOT00000094647 | 0.09 | 1 | 0.06 | 2.9e-05 | 5.91 | 3.45e-09 | 0 | FALSE |
| PL | AABR07056633.1 | alternative TSS | ENSRNOT00000104436 | 0.09 | 1 | 0.06 | 2.6e-05 | -5.91 | 3.45e-09 | 0 | FALSE |
| PL | Vezt | gene expression | ENSRNOG00000006514 | 0.35 | 7 | 0.41 | 4.8e-33 | -7.78 | 7.31e-15 | 0.15 | FALSE |
| PL | Ndufa12 | gene expression | ENSRNOG00000007407 | 0.07 | 18 | 0.07 | 1.0e-05 | -8.11 | 5.10e-16 | 0.55 | TRUE |
| PL | Socs2 | gene expression | ENSRNOG00000008965 | 0.05 | 1 | 0.04 | 9.1e-04 | 9.89 | 4.49e-23 | 0.04 | TRUE |
| PL | Nudt4 | gene expression | ENSRNOG00000009094 | 0.68 | 84 | 0.55 | 1.1e-49 | 7.06 | 1.67e-12 | 0 | FALSE |
| PL | Fgd6 | gene expression | ENSRNOG00000054515 | 0.07 | 7 | 0.1 | 5.4e-08 | -6.89 | 5.41e-12 | 0.38 | FALSE |
| PL | Socs2 | isoform ratio | ENSRNOT00000011948 | 0.1 | 1 | 0.05 | 1.4e-04 | 6.65 | 2.87e-11 | 0.01 | FALSE |
| PL | Socs2 | isoform ratio | ENSRNOT00000103867 | 0.1 | 1 | 0.05 | 1.3e-04 | -6.65 | 2.87e-11 | 0.01 | FALSE |
| PL | Vezt | mRNA stability | ENSRNOG00000006514 | 0.27 | 1 | 0.38 | 1.6e-30 | 7.84 | 4.33e-15 | 0.2 | FALSE |
| PL | Plxnc1 | mRNA stability | ENSRNOG00000007970 | 0.05 | 1 | 0.05 | 1.2e-04 | 8.59 | 8.58e-18 | 0.03 | FALSE |
| PL | Cradd | mRNA stability | ENSRNOG00000008507 | 0.09 | 1 | 0.07 | 2.3e-06 | 9.69 | 3.44e-22 | 0.09 | FALSE |