Best TWAS P=8.170789e-14 · Best GWAS P=8.170789e-14 conditioned to 1
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | Stk17b | gene expression | ENSRNOG00000012502 | 0.04 | 0.02 | blup | 1707 | 0.02 | 1.3e-03 | -6.4 | 7.0 | 2.3e-12 | -0.99 | 0.43 | 0.52 | FALSE |
2 | Adipose | Ccdc150 | gene expression | ENSRNOG00000013318 | 0.03 | 0.02 | top1 | 1 | 0.02 | 5.4e-03 | -5.8 | -5.8 | 8.0e-09 | 0.92 | 0.06 | 0.03 | FALSE |
3 | Adipose | Pgap1 | gene expression | ENSRNOG00000013388 | 0.06 | 0.04 | top1 | 1 | 0.04 | 1.6e-05 | -6.9 | -6.9 | 5.7e-12 | 0.93 | 0.45 | 0.19 | FALSE |
4 | Adipose | Coq10b | gene expression | ENSRNOG00000014456 | 0.05 | 0.03 | top1 | 1 | 0.03 | 1.6e-04 | -6.5 | -6.5 | 7.9e-11 | 0.81 | 0.15 | 0.06 | FALSE |
5 | Adipose | Hspd1 | gene expression | ENSRNOG00000014525 | 0.02 | 0.02 | top1 | 1 | 0.02 | 1.7e-03 | -6.3 | -6.3 | 3.7e-10 | 0.66 | 0.05 | 0.03 | FALSE |
6 | Adipose | Boll | gene expression | ENSRNOG00000054379 | 0.06 | 0.05 | top1 | 1 | 0.06 | 9.8e-07 | -6.3 | 6.3 | 3.5e-10 | -0.65 | 0.77 | 0.03 | FALSE |
7 | Adipose | NA | gene expression | ENSRNOG00000064815 | 0.06 | 0.05 | top1 | 1 | 0.05 | 7.2e-06 | -6.8 | -6.8 | 1.3e-11 | 0.96 | 0.38 | 0.05 | FALSE |
8 | Adipose | NA | gene expression | ENSRNOG00000067131 | 0.07 | 0.04 | top1 | 1 | 0.04 | 1.5e-05 | -6.4 | 6.4 | 1.6e-10 | -0.94 | 0.24 | 0.09 | FALSE |
9 | Adipose | Slc39a10 | isoform ratio | ENSRNOT00000016262 | 0.02 | 0.02 | top1 | 1 | 0.01 | 7.3e-03 | -6.3 | 6.3 | 3.0e-10 | -0.90 | 0.06 | 0.03 | FALSE |
10 | Adipose | Gtf3c3 | intron excision ratio | chr9:55938738:55941796 | 0.02 | 0.01 | top1 | 1 | 0.01 | 1.8e-02 | -6.0 | -6.0 | 2.3e-09 | 0.90 | 0.06 | 0.03 | FALSE |
11 | Adipose | Hecw2 | intron excision ratio | chr9:55488290:55492328 | 0.02 | 0.01 | top1 | 1 | 0.01 | 5.6e-02 | -6.5 | 6.5 | 6.6e-11 | -0.98 | 0.06 | 0.03 | FALSE |
12 | Adipose | Slc39a10 | mRNA stability | ENSRNOG00000011677 | 0.03 | 0.03 | top1 | 1 | 0.03 | 7.2e-04 | -5.8 | 5.8 | 7.7e-09 | -0.86 | 0.06 | 0.03 | FALSE |
13 | Adipose | Pgap1 | mRNA stability | ENSRNOG00000013388 | 0.16 | 0.12 | enet | 127 | 0.14 | 2.1e-15 | -6.5 | -7.0 | 2.5e-12 | 0.89 | 0.99 | 0.01 | FALSE |
14 | Adipose | Sf3b1 | mRNA stability | ENSRNOG00000013516 | 0.18 | 0.02 | enet | 209 | 0.03 | 3.5e-04 | -6.8 | 5.9 | 3.7e-09 | -0.69 | 0.25 | 0.53 | FALSE |
15 | Adipose | Coq10b | mRNA stability | ENSRNOG00000014456 | 0.02 | 0.01 | blup | 1472 | 0.02 | 2.3e-03 | -6.5 | -6.9 | 4.1e-12 | 0.81 | 0.38 | 0.46 | FALSE |
16 | BLA | Coq10b | gene expression | ENSRNOG00000014456 | 0.05 | 0.03 | top1 | 1 | 0.03 | 6.9e-03 | -6.9 | -6.9 | 3.8e-12 | 0.83 | 0.06 | 0.06 | FALSE |
17 | BLA | NA | gene expression | ENSRNOG00000064815 | 0.14 | 0.10 | blup | 1961 | 0.11 | 1.2e-06 | -6.9 | -6.0 | 1.8e-09 | 0.81 | 0.61 | 0.38 | FALSE |
18 | BLA | NA | gene expression | ENSRNOG00000065339 | 0.05 | 0.04 | enet | 17 | 0.04 | 2.8e-03 | -6.9 | -6.6 | 3.1e-11 | 0.72 | 0.36 | 0.45 | FALSE |
19 | Brain | Gtf3c3 | alternative polyA | ENSRNOT00000002864 | 0.07 | 0.03 | lasso | 21 | 0.05 | 1.3e-05 | -5.7 | 6.2 | 4.3e-10 | -0.94 | 0.96 | 0.01 | FALSE |
20 | Brain | Ccdc150 | gene expression | ENSRNOG00000013318 | 0.03 | 0.02 | top1 | 1 | 0.02 | 9.5e-03 | -6.7 | -6.7 | 2.0e-11 | 0.76 | 0.06 | 0.03 | FALSE |
21 | Brain | Pgap1 | gene expression | ENSRNOG00000013388 | 0.23 | 0.29 | top1 | 1 | 0.29 | 2.3e-27 | -6.6 | -6.6 | 3.9e-11 | 0.94 | 0.94 | 0.06 | FALSE |
22 | Brain | Coq10b | gene expression | ENSRNOG00000014456 | 0.14 | 0.17 | enet | 254 | 0.18 | 4.3e-16 | -7.0 | -7.1 | 1.3e-12 | 0.82 | 0.18 | 0.82 | FALSE |
23 | Brain | NA | gene expression | ENSRNOG00000064815 | 0.27 | 0.29 | top1 | 1 | 0.29 | 1.5e-27 | -6.9 | -6.9 | 6.0e-12 | 0.96 | 0.82 | 0.18 | FALSE |
24 | Brain | NA | gene expression | ENSRNOG00000065623 | 0.03 | 0.02 | blup | 1944 | 0.03 | 7.6e-04 | -6.9 | -6.4 | 1.9e-10 | 0.82 | 0.54 | 0.37 | FALSE |
25 | Brain | Pgap1 | mRNA stability | ENSRNOG00000013388 | 0.06 | 0.03 | top1 | 1 | 0.03 | 7.4e-04 | -5.9 | -5.9 | 3.7e-09 | 0.92 | 0.44 | 0.02 | FALSE |
26 | Brain | Sf3b1 | mRNA stability | ENSRNOG00000013516 | 0.03 | 0.04 | top1 | 1 | 0.04 | 3.0e-04 | -6.4 | 6.4 | 2.0e-10 | -0.75 | 0.06 | 0.03 | FALSE |
27 | Brain | Coq10b | mRNA stability | ENSRNOG00000014456 | 0.05 | 0.04 | lasso | 34 | 0.04 | 2.7e-04 | -6.3 | -6.3 | 3.3e-10 | 0.69 | 0.65 | 0.34 | FALSE |
28 | Brain | Plcl1 | mRNA stability | ENSRNOG00000032659 | 0.04 | 0.04 | lasso | 8 | 0.04 | 9.7e-05 | -4.4 | 5.5 | 4.3e-08 | -0.62 | 0.63 | 0.37 | FALSE |
29 | IL | Gtf3c3 | alternative polyA | ENSRNOT00000002864 | 0.17 | 0.04 | blup | 1229 | 0.06 | 1.4e-02 | -6.3 | 7.1 | 1.6e-12 | -0.93 | 0.34 | 0.22 | FALSE |
30 | IL | Gtf3c3 | isoform ratio | ENSRNOT00000002864 | 0.14 | 0.03 | blup | 1229 | 0.06 | 1.3e-02 | -6.3 | 7.1 | 1.4e-12 | -0.93 | 0.30 | 0.21 | FALSE |
31 | LHb | Gtf3c3 | alternative polyA | ENSRNOT00000002864 | 0.17 | 0.05 | top1 | 1 | 0.05 | 2.5e-02 | -6.0 | 6.0 | 2.3e-09 | -0.95 | 0.06 | 0.05 | FALSE |
32 | LHb | Coq10b | gene expression | ENSRNOG00000014456 | 0.60 | 0.06 | top1 | 1 | 0.06 | 1.6e-02 | -7.0 | -7.0 | 3.4e-12 | 0.78 | 0.05 | 0.10 | FALSE |
33 | LHb | Gtf3c3 | isoform ratio | ENSRNOT00000002864 | 0.19 | 0.07 | blup | 1227 | 0.11 | 1.6e-03 | -7.2 | 7.1 | 1.4e-12 | -0.97 | 0.35 | 0.45 | FALSE |
34 | Liver | Slc39a10 | gene expression | ENSRNOG00000011677 | 0.03 | 0.01 | blup | 1915 | 0.01 | 8.0e-03 | -6.0 | 6.2 | 4.4e-10 | -0.87 | 0.53 | 0.28 | FALSE |
35 | Liver | Ankrd44 | gene expression | ENSRNOG00000021384 | 0.04 | 0.03 | enet | 26 | 0.03 | 1.2e-04 | -6.5 | 6.4 | 2.0e-10 | -0.69 | 0.80 | 0.18 | FALSE |
36 | Liver | Pgap1 | mRNA stability | ENSRNOG00000013388 | 0.03 | 0.01 | blup | 1843 | 0.01 | 1.5e-02 | -6.5 | -7.0 | 2.6e-12 | 0.91 | 0.29 | 0.52 | FALSE |
37 | Liver | Coq10b | mRNA stability | ENSRNOG00000014456 | 0.03 | 0.02 | top1 | 1 | 0.02 | 5.8e-03 | -5.9 | -5.9 | 2.9e-09 | 0.74 | 0.05 | 0.03 | FALSE |
38 | Liver | Hspd1 | mRNA stability | ENSRNOG00000014525 | 0.22 | 0.19 | top1 | 1 | 0.19 | 2.6e-20 | -6.8 | -6.8 | 9.1e-12 | 0.81 | 0.32 | 0.68 | FALSE |
39 | NAcc | Gtf3c3 | alternative polyA | ENSRNOT00000002864 | 0.04 | 0.03 | top1 | 1 | 0.03 | 1.7e-03 | -6.2 | 6.2 | 4.3e-10 | -0.93 | 0.08 | 0.03 | FALSE |
40 | NAcc | Hecw2 | gene expression | ENSRNOG00000013257 | 0.04 | 0.03 | top1 | 1 | 0.03 | 5.1e-03 | -7.5 | -7.5 | 8.2e-14 | 0.97 | 0.06 | 0.15 | TRUE |
41 | NAcc | Pgap1 | gene expression | ENSRNOG00000013388 | 0.13 | 0.12 | top1 | 1 | 0.12 | 4.2e-09 | -6.2 | -6.2 | 4.3e-10 | 0.91 | 0.98 | 0.01 | FALSE |
42 | NAcc | Sf3b1 | gene expression | ENSRNOG00000013516 | 0.04 | 0.01 | top1 | 1 | 0.01 | 5.1e-02 | -6.0 | 6.0 | 2.2e-09 | -0.60 | 0.05 | 0.03 | FALSE |
43 | NAcc | Coq10b | gene expression | ENSRNOG00000014456 | 0.18 | 0.06 | enet | 190 | 0.07 | 3.9e-06 | -7.0 | -6.7 | 2.0e-11 | 0.70 | 0.20 | 0.80 | FALSE |
44 | NAcc | Mob4 | gene expression | ENSRNOG00000014980 | 0.06 | 0.04 | top1 | 1 | 0.04 | 5.0e-04 | -6.8 | -6.8 | 9.0e-12 | 0.79 | 0.09 | 0.13 | FALSE |
45 | NAcc | Rftn2 | gene expression | ENSRNOG00000015594 | 0.05 | 0.03 | top1 | 1 | 0.03 | 5.4e-03 | -6.3 | -6.3 | 3.0e-10 | 0.64 | 0.06 | 0.03 | FALSE |
46 | NAcc | Dnah7 | gene expression | ENSRNOG00000060984 | 0.04 | 0.04 | top1 | 1 | 0.04 | 8.8e-04 | -6.0 | -6.0 | 2.6e-09 | 0.96 | 0.07 | 0.03 | FALSE |
47 | NAcc | NA | gene expression | ENSRNOG00000064815 | 0.22 | 0.23 | top1 | 1 | 0.23 | 9.9e-17 | -6.2 | -6.2 | 4.3e-10 | 0.94 | 1.00 | 0.00 | FALSE |
48 | NAcc | NA | gene expression | ENSRNOG00000065623 | 0.09 | 0.04 | enet | 805 | 0.05 | 2.3e-04 | -6.9 | -6.1 | 8.1e-10 | 0.82 | 0.88 | 0.12 | FALSE |
49 | NAcc | Slc39a10 | mRNA stability | ENSRNOG00000011677 | 0.05 | 0.03 | lasso | 2 | 0.04 | 5.9e-04 | -6.6 | 5.7 | 1.4e-08 | -0.87 | 0.40 | 0.30 | FALSE |
50 | NAcc | Coq10b | mRNA stability | ENSRNOG00000014456 | 0.11 | 0.08 | top1 | 1 | 0.08 | 9.5e-07 | -6.3 | -6.3 | 2.4e-10 | 0.74 | 0.76 | 0.08 | FALSE |
51 | OFC | Pgap1 | gene expression | ENSRNOG00000013388 | 0.18 | 0.03 | blup | 1059 | 0.03 | 5.5e-02 | -6.6 | -6.9 | 4.1e-12 | 0.91 | 0.18 | 0.25 | FALSE |
52 | PL | Slc39a10 | alternative TSS | ENSRNOT00000093748 | 0.03 | 0.01 | blup | 1913 | 0.02 | 1.8e-02 | -6.5 | -6.5 | 9.0e-11 | 0.91 | 0.48 | 0.33 | FALSE |
53 | PL | Pgap1 | gene expression | ENSRNOG00000013388 | 0.09 | 0.05 | top1 | 1 | 0.05 | 1.8e-04 | -7.3 | -7.3 | 2.3e-13 | 0.94 | 0.09 | 0.89 | FALSE |
54 | PL | Coq10b | gene expression | ENSRNOG00000014456 | 0.07 | 0.04 | lasso | 27 | 0.05 | 9.1e-05 | -6.9 | -7.0 | 3.1e-12 | 0.79 | 0.21 | 0.78 | FALSE |
55 | PL | Rftn2 | gene expression | ENSRNOG00000015594 | 0.03 | 0.02 | blup | 1411 | 0.02 | 1.1e-02 | -6.3 | -6.5 | 1.0e-10 | 0.70 | 0.50 | 0.39 | FALSE |
56 | PL | Plcl1 | gene expression | ENSRNOG00000032659 | 0.03 | 0.01 | blup | 1644 | 0.01 | 4.0e-02 | -4.9 | 6.4 | 1.6e-10 | -0.72 | 0.34 | 0.43 | FALSE |
57 | PL | NA | gene expression | ENSRNOG00000064815 | 0.10 | 0.09 | top1 | 1 | 0.09 | 3.4e-07 | -7.2 | -7.2 | 6.3e-13 | 0.96 | 0.32 | 0.65 | FALSE |
58 | PL | Gtf3c3 | isoform ratio | ENSRNOT00000002864 | 0.04 | 0.00 | top1 | 1 | 0.00 | 1.6e-01 | -6.0 | 6.0 | 2.1e-09 | -0.86 | 0.07 | 0.03 | FALSE |
59 | PL | Slc39a10 | isoform ratio | ENSRNOT00000016262 | 0.03 | 0.01 | blup | 1913 | 0.02 | 1.5e-02 | -6.6 | 6.6 | 5.5e-11 | -0.93 | 0.50 | 0.37 | FALSE |
60 | PL | Slc39a10 | intron excision ratio | chr9:54876271:54928715 | 0.04 | 0.03 | top1 | 1 | 0.03 | 1.2e-03 | -6.5 | 6.5 | 9.9e-11 | -0.94 | 0.07 | 0.04 | FALSE |
61 | PL | Slc39a10 | intron excision ratio | chr9:54911589:54928715 | 0.03 | 0.03 | enet | 26 | 0.03 | 4.4e-03 | -6.3 | -6.6 | 3.0e-11 | 0.96 | 0.51 | 0.37 | FALSE |
62 | PL | NA | intron excision ratio | chr9:54876271:54928715 | 0.03 | 0.03 | top1 | 1 | 0.03 | 1.2e-03 | -6.5 | 6.5 | 9.9e-11 | -0.93 | 0.07 | 0.04 | FALSE |
63 | PL | NA | intron excision ratio | chr9:54911589:54928715 | 0.03 | 0.02 | top1 | 1 | 0.03 | 5.2e-03 | -6.6 | -6.6 | 3.6e-11 | 0.93 | 0.07 | 0.04 | FALSE |
64 | PL | Slc39a10 | mRNA stability | ENSRNOG00000011677 | 0.08 | 0.01 | blup | 1913 | 0.05 | 5.6e-05 | -6.6 | 5.3 | 1.3e-07 | -0.77 | 0.50 | 0.49 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.