Best TWAS P=8.17e-14 · Best GWAS P=8.17e-14 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Stk17b | gene expression | ENSRNOG00000012502 | 0.04 | 1707 | 0.02 | 1.3e-03 | 7.02 | 2.27e-12 | 0.52 | FALSE |
| Adipose | Ccdc150 | gene expression | ENSRNOG00000013318 | 0.03 | 1 | 0.02 | 5.4e-03 | -5.77 | 8.04e-09 | 0.03 | FALSE |
| Adipose | Pgap1 | gene expression | ENSRNOG00000013388 | 0.06 | 1 | 0.04 | 1.6e-05 | -6.89 | 5.66e-12 | 0.19 | FALSE |
| Adipose | Coq10b | gene expression | ENSRNOG00000014456 | 0.05 | 1 | 0.03 | 1.6e-04 | -6.5 | 7.89e-11 | 0.06 | FALSE |
| Adipose | Hspd1 | gene expression | ENSRNOG00000014525 | 0.02 | 1 | 0.02 | 1.7e-03 | -6.27 | 3.68e-10 | 0.03 | FALSE |
| Adipose | Boll | gene expression | ENSRNOG00000054379 | 0.06 | 1 | 0.06 | 9.8e-07 | 6.27 | 3.51e-10 | 0.03 | FALSE |
| Adipose | ENSRNOG00000064815 | gene expression | ENSRNOG00000064815 | 0.06 | 1 | 0.05 | 7.2e-06 | -6.76 | 1.34e-11 | 0.05 | FALSE |
| Adipose | ENSRNOG00000067131 | gene expression | ENSRNOG00000067131 | 0.07 | 1 | 0.04 | 1.5e-05 | 6.4 | 1.59e-10 | 0.09 | FALSE |
| Adipose | Slc39a10 | isoform ratio | ENSRNOT00000016262 | 0.02 | 1 | 0.01 | 7.3e-03 | 6.3 | 2.97e-10 | 0.03 | FALSE |
| Adipose | Gtf3c3 | intron excision ratio | chr9:55938738:55941796 | 0.02 | 1 | 0.01 | 1.8e-02 | -5.97 | 2.31e-09 | 0.03 | FALSE |
| Adipose | Hecw2 | intron excision ratio | chr9:55488290:55492328 | 0.02 | 1 | 0.01 | 5.6e-02 | 6.53 | 6.59e-11 | 0.03 | FALSE |
| Adipose | Slc39a10 | mRNA stability | ENSRNOG00000011677 | 0.03 | 1 | 0.03 | 7.2e-04 | 5.77 | 7.70e-09 | 0.03 | FALSE |
| Adipose | Pgap1 | mRNA stability | ENSRNOG00000013388 | 0.16 | 127 | 0.14 | 2.1e-15 | -7 | 2.55e-12 | 0.01 | FALSE |
| Adipose | Sf3b1 | mRNA stability | ENSRNOG00000013516 | 0.18 | 209 | 0.03 | 3.5e-04 | 5.9 | 3.69e-09 | 0.53 | FALSE |
| Adipose | Coq10b | mRNA stability | ENSRNOG00000014456 | 0.02 | 1472 | 0.02 | 2.3e-03 | -6.93 | 4.15e-12 | 0.46 | FALSE |
| BLA | Coq10b | gene expression | ENSRNOG00000014456 | 0.05 | 1 | 0.03 | 6.9e-03 | -6.95 | 3.77e-12 | 0.06 | FALSE |
| BLA | ENSRNOG00000064815 | gene expression | ENSRNOG00000064815 | 0.14 | 1961 | 0.11 | 1.2e-06 | -6.01 | 1.84e-09 | 0.38 | FALSE |
| BLA | ENSRNOG00000065339 | gene expression | ENSRNOG00000065339 | 0.05 | 17 | 0.04 | 2.8e-03 | -6.64 | 3.08e-11 | 0.45 | FALSE |
| Brain | Gtf3c3 | alternative polyA | ENSRNOT00000002864 | 0.07 | 21 | 0.05 | 1.3e-05 | 6.24 | 4.33e-10 | 0.01 | FALSE |
| Brain | Ccdc150 | gene expression | ENSRNOG00000013318 | 0.03 | 1 | 0.02 | 9.5e-03 | -6.71 | 1.97e-11 | 0.03 | FALSE |
| Brain | Pgap1 | gene expression | ENSRNOG00000013388 | 0.23 | 1 | 0.29 | 2.3e-27 | -6.61 | 3.87e-11 | 0.06 | FALSE |
| Brain | Coq10b | gene expression | ENSRNOG00000014456 | 0.14 | 254 | 0.18 | 4.3e-16 | -7.09 | 1.33e-12 | 0.82 | FALSE |
| Brain | ENSRNOG00000064815 | gene expression | ENSRNOG00000064815 | 0.27 | 1 | 0.29 | 1.5e-27 | -6.88 | 6.02e-12 | 0.18 | FALSE |
| Brain | ENSRNOG00000065623 | gene expression | ENSRNOG00000065623 | 0.03 | 1944 | 0.03 | 7.6e-04 | -6.37 | 1.93e-10 | 0.37 | FALSE |
| Brain | Pgap1 | mRNA stability | ENSRNOG00000013388 | 0.06 | 1 | 0.03 | 7.4e-04 | -5.9 | 3.67e-09 | 0.02 | FALSE |
| Brain | Sf3b1 | mRNA stability | ENSRNOG00000013516 | 0.03 | 1 | 0.04 | 3.0e-04 | 6.36 | 1.99e-10 | 0.03 | FALSE |
| Brain | Coq10b | mRNA stability | ENSRNOG00000014456 | 0.05 | 34 | 0.04 | 2.7e-04 | -6.28 | 3.34e-10 | 0.34 | FALSE |
| Brain | Plcl1 | mRNA stability | ENSRNOG00000032659 | 0.04 | 8 | 0.04 | 9.7e-05 | 5.48 | 4.33e-08 | 0.37 | FALSE |
| IL | Gtf3c3 | alternative polyA | ENSRNOT00000002864 | 0.17 | 1229 | 0.06 | 1.4e-02 | 7.06 | 1.63e-12 | 0.22 | FALSE |
| IL | Gtf3c3 | isoform ratio | ENSRNOT00000002864 | 0.14 | 1229 | 0.06 | 1.3e-02 | 7.08 | 1.41e-12 | 0.21 | FALSE |
| LHb | Gtf3c3 | alternative polyA | ENSRNOT00000002864 | 0.17 | 1 | 0.05 | 2.5e-02 | 5.97 | 2.31e-09 | 0.05 | FALSE |
| LHb | Coq10b | gene expression | ENSRNOG00000014456 | 0.6 | 1 | 0.06 | 1.6e-02 | -6.96 | 3.39e-12 | 0.1 | FALSE |
| LHb | Gtf3c3 | isoform ratio | ENSRNOT00000002864 | 0.19 | 1227 | 0.11 | 1.6e-03 | 7.09 | 1.39e-12 | 0.45 | FALSE |
| Liver | Slc39a10 | gene expression | ENSRNOG00000011677 | 0.03 | 1915 | 0.01 | 8.0e-03 | 6.24 | 4.39e-10 | 0.28 | FALSE |
| Liver | Ankrd44 | gene expression | ENSRNOG00000021384 | 0.04 | 26 | 0.03 | 1.2e-04 | 6.36 | 2.00e-10 | 0.18 | FALSE |
| Liver | Pgap1 | mRNA stability | ENSRNOG00000013388 | 0.03 | 1843 | 0.01 | 1.5e-02 | -7 | 2.63e-12 | 0.52 | FALSE |
| Liver | Coq10b | mRNA stability | ENSRNOG00000014456 | 0.03 | 1 | 0.02 | 5.8e-03 | -5.94 | 2.85e-09 | 0.03 | FALSE |
| Liver | Hspd1 | mRNA stability | ENSRNOG00000014525 | 0.22 | 1 | 0.19 | 2.6e-20 | -6.82 | 9.12e-12 | 0.68 | FALSE |
| NAcc | Gtf3c3 | alternative polyA | ENSRNOT00000002864 | 0.04 | 1 | 0.03 | 1.7e-03 | 6.24 | 4.32e-10 | 0.03 | FALSE |
| NAcc | Hecw2 | gene expression | ENSRNOG00000013257 | 0.04 | 1 | 0.03 | 5.1e-03 | -7.47 | 8.17e-14 | 0.15 | TRUE |
| NAcc | Pgap1 | gene expression | ENSRNOG00000013388 | 0.13 | 1 | 0.12 | 4.2e-09 | -6.24 | 4.32e-10 | 0.01 | FALSE |
| NAcc | Sf3b1 | gene expression | ENSRNOG00000013516 | 0.04 | 1 | 0.01 | 5.1e-02 | 5.98 | 2.22e-09 | 0.03 | FALSE |
| NAcc | Coq10b | gene expression | ENSRNOG00000014456 | 0.18 | 190 | 0.07 | 3.9e-06 | -6.7 | 2.03e-11 | 0.8 | FALSE |
| NAcc | Mob4 | gene expression | ENSRNOG00000014980 | 0.06 | 1 | 0.04 | 5.0e-04 | -6.82 | 8.96e-12 | 0.13 | FALSE |
| NAcc | Rftn2 | gene expression | ENSRNOG00000015594 | 0.05 | 1 | 0.03 | 5.4e-03 | -6.3 | 2.97e-10 | 0.03 | FALSE |
| NAcc | Dnah7 | gene expression | ENSRNOG00000060984 | 0.04 | 1 | 0.04 | 8.8e-04 | -5.95 | 2.62e-09 | 0.03 | FALSE |
| NAcc | ENSRNOG00000064815 | gene expression | ENSRNOG00000064815 | 0.22 | 1 | 0.23 | 9.9e-17 | -6.24 | 4.32e-10 | 0 | FALSE |
| NAcc | ENSRNOG00000065623 | gene expression | ENSRNOG00000065623 | 0.09 | 805 | 0.05 | 2.3e-04 | -6.14 | 8.12e-10 | 0.12 | FALSE |
| NAcc | Slc39a10 | mRNA stability | ENSRNOG00000011677 | 0.05 | 2 | 0.04 | 5.9e-04 | 5.68 | 1.36e-08 | 0.3 | FALSE |
| NAcc | Coq10b | mRNA stability | ENSRNOG00000014456 | 0.11 | 1 | 0.08 | 9.5e-07 | -6.33 | 2.41e-10 | 0.08 | FALSE |
| OFC | Pgap1 | gene expression | ENSRNOG00000013388 | 0.18 | 1059 | 0.03 | 5.5e-02 | -6.93 | 4.10e-12 | 0.25 | FALSE |
| PL | Slc39a10 | alternative TSS | ENSRNOT00000093748 | 0.03 | 1913 | 0.02 | 1.8e-02 | -6.48 | 8.96e-11 | 0.33 | FALSE |
| PL | Pgap1 | gene expression | ENSRNOG00000013388 | 0.09 | 1 | 0.05 | 1.8e-04 | -7.33 | 2.30e-13 | 0.89 | FALSE |
| PL | Coq10b | gene expression | ENSRNOG00000014456 | 0.07 | 27 | 0.05 | 9.1e-05 | -6.97 | 3.09e-12 | 0.78 | FALSE |
| PL | Rftn2 | gene expression | ENSRNOG00000015594 | 0.03 | 1411 | 0.02 | 1.1e-02 | -6.46 | 1.04e-10 | 0.39 | FALSE |
| PL | Plcl1 | gene expression | ENSRNOG00000032659 | 0.03 | 1644 | 0.01 | 4.0e-02 | 6.4 | 1.56e-10 | 0.43 | FALSE |
| PL | ENSRNOG00000064815 | gene expression | ENSRNOG00000064815 | 0.1 | 1 | 0.09 | 3.4e-07 | -7.19 | 6.30e-13 | 0.65 | FALSE |
| PL | Gtf3c3 | isoform ratio | ENSRNOT00000002864 | 0.04 | 1 | 0 | 1.6e-01 | 5.99 | 2.13e-09 | 0.03 | FALSE |
| PL | Slc39a10 | isoform ratio | ENSRNOT00000016262 | 0.03 | 1913 | 0.02 | 1.5e-02 | 6.56 | 5.54e-11 | 0.37 | FALSE |
| PL | Slc39a10 | intron excision ratio | chr9:54876271:54928715 | 0.04 | 1 | 0.03 | 1.2e-03 | 6.47 | 9.89e-11 | 0.04 | FALSE |
| PL | Slc39a10 | intron excision ratio | chr9:54911589:54928715 | 0.03 | 26 | 0.03 | 4.4e-03 | -6.65 | 3.01e-11 | 0.37 | FALSE |
| PL | ENSRNOG00000067131 | intron excision ratio | chr9:54876271:54928715 | 0.03 | 1 | 0.03 | 1.2e-03 | 6.47 | 9.89e-11 | 0.04 | FALSE |
| PL | ENSRNOG00000067131 | intron excision ratio | chr9:54911589:54928715 | 0.03 | 1 | 0.03 | 5.2e-03 | -6.62 | 3.64e-11 | 0.04 | FALSE |
| PL | Slc39a10 | mRNA stability | ENSRNOG00000011677 | 0.08 | 1913 | 0.05 | 5.6e-05 | 5.28 | 1.27e-07 | 0.49 | FALSE |