Best TWAS P=4.57e-09 · Best GWAS P=5.75e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Aox2 | gene expression | Aox2 | 0.07 | 2416 | 0.04 | 8.4e-06 | -5.25 | 1.54e-07 | 0.1 | FALSE |
| Adipose | Aox1 | isoform ratio | XR_594396.3 | 0.06 | 1 | 0.06 | 5.7e-07 | -5.18 | 2.24e-07 | 0.37 | FALSE |
| Adipose | Cflar | mRNA stability | Cflar | 0.09 | 1 | 0.06 | 1.3e-07 | -5.18 | 2.24e-07 | 0.87 | FALSE |
| BLA | Kctd18 | alternative TSS | XM_017596364.2 | 0.1 | 11 | 0.08 | 7.3e-05 | 5.43 | 5.67e-08 | 0.48 | FALSE |
| BLA | Kctd18 | alternative TSS | XM_039083313.1 | 0.07 | 1 | 0.04 | 2.4e-03 | -5.33 | 1.00e-07 | 0.06 | FALSE |
| BLA | Kctd18 | isoform ratio | XM_006244967.3 | 0.1 | 2554 | 0.06 | 3.9e-04 | -5.27 | 1.34e-07 | 0.32 | FALSE |
| BLA | Kctd18 | intron excision ratio | chr9_59515068_59515815 | 0.09 | 2554 | 0.06 | 2.4e-04 | 5.45 | 5.08e-08 | 0.56 | FALSE |
| BLA | Aox1 | mRNA stability | Aox1 | 0.08 | 2544 | 0.03 | 9.4e-03 | -5.3 | 1.16e-07 | 0.34 | FALSE |
| Eye | Tmem237 | isoform ratio | XM_039083617.1 | 0.55 | 53 | 0.18 | 1.2e-03 | 5.2 | 1.99e-07 | 0.5 | FALSE |
| LHb | Kctd18 | isoform ratio | XM_039083317.1 | 0.16 | 403 | 0.08 | 5.6e-03 | -5.3 | 1.15e-07 | 0.34 | FALSE |
| Liver | Casp8 | alternative TSS | XM_039084164.1 | 0.07 | 1 | 0.04 | 2.1e-05 | -5.18 | 2.24e-07 | 0.53 | FALSE |
| Liver | Kctd18 | gene expression | Kctd18 | 0.06 | 2554 | 0.02 | 1.1e-03 | 5.37 | 7.71e-08 | 0.37 | FALSE |
| Liver | LOC102550420 | intron excision ratio | chr9_59534626_59536935 | 0.03 | 1 | 0.03 | 6.4e-04 | 5.18 | 2.24e-07 | 0.04 | FALSE |
| NAcc | Kctd18 | alternative TSS | XM_017596364.2 | 0.03 | 4 | 0.02 | 2.8e-03 | 5.86 | 4.57e-09 | 0.57 | TRUE |
| NAcc | Kctd18 | alternative TSS | XM_017596364.2 | 0.03 | 1 | 0.02 | 2.1e-03 | -5.33 | 1.00e-07 | 0.07 | FALSE |
| NAcc | Kctd18 | alternative TSS | XM_039083317.1 | 0.04 | 117 | 0.02 | 1.0e-03 | 5.48 | 4.23e-08 | 0.2 | FALSE |
| NAcc | Aox4 | gene expression | Aox4 | 0.05 | 1 | 0.04 | 2.1e-05 | -5.4 | 6.77e-08 | 0.38 | FALSE |
| NAcc | Maip1 | gene expression | Maip1 | 0.05 | 27 | 0.03 | 1.2e-04 | 5.83 | 5.53e-09 | 0.81 | FALSE |
| NAcc | Kctd18 | isoform ratio | XM_006244967.3 | 0.13 | 25 | 0.12 | 3.1e-13 | -5.46 | 4.70e-08 | 0.35 | FALSE |
| NAcc | Kctd18 | intron excision ratio | chr9_59515068_59516751 | 0.06 | 1 | 0.04 | 8.1e-06 | 5.27 | 1.33e-07 | 0.46 | FALSE |
| PL | Kctd18 | intron excision ratio | chr9_59515068_59517376 | 0.03 | 5 | 0.01 | 8.3e-03 | 5.75 | 9.16e-09 | 0.55 | FALSE |