Best TWAS P = 9.69e-10 · Best GWAS P= 2.45e-09 conditioned to 2.27e-02
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Plcb4 | alternative TSS | NM_024353.2 | 0.08 | 1407 | 0.01 | 1.0e-02 | -5.55 | 2.82e-08 | 0.36 | TRUE |
| Adipose | Plcb4 | gene expression | Plcb4 | 0.13 | 1 | 0.09 | 2.4e-10 | 5.25 | 1.55e-07 | 0.59 | FALSE |
| Adipose | Plcb4 | isoform ratio | XM_063283133.1 | 0.05 | 1 | 0.06 | 9.7e-08 | -5.32 | 1.02e-07 | 0.67 | FALSE |
| Adipose | Plcb4 | isoform ratio | XM_063283135.1 | 0.03 | 4 | 0.04 | 7.5e-05 | 5.48 | 4.32e-08 | 0.58 | FALSE |
| Adipose | Plcb4 | intron excision ratio | chr3_143493493_143559809 | 0.65 | 71 | 0.53 | 1.0e-68 | -5.24 | 1.58e-07 | 0.54 | FALSE |
| Adipose | Plcb4 | mRNA stability | Plcb4 | 0.06 | 28 | 0.05 | 1.6e-06 | 5.4 | 6.74e-08 | 0.53 | FALSE |
| BLA | Plcb4 | alternative TSS | XM_039104319.2 | 0.12 | 1407 | 0.05 | 1.0e-03 | 6.11 | 9.69e-10 | 0.51 | TRUE |
| BLA | Plcb4 | alternative TSS | XM_039104319.2 | 0.09 | 1407 | 0.05 | 1.5e-03 | 6.03 | 1.62e-09 | 0.52 | FALSE |
| BLA | Plcb4 | gene expression | Plcb4 | 0.31 | 52 | 0.2 | 8.6e-11 | 5.34 | 9.31e-08 | 0.63 | FALSE |
| BLA | Plcb4 | intron excision ratio | chr3_143493493_143559809 | 0.05 | 47 | 0.03 | 9.4e-03 | 6.07 | 1.25e-09 | 0.24 | FALSE |
| Brain | Plcb4 | alternative TSS | XM_039104319.2 | 0.57 | 56 | 0.39 | 1.1e-38 | 5.38 | 7.43e-08 | 0.65 | FALSE |
| Brain | Plcb4 | alternative TSS | XM_039104319.2 | 0.56 | 56 | 0.42 | 8.8e-42 | 5.38 | 7.58e-08 | 0.67 | TRUE |
| Brain | Plcb4 | alternative TSS | XM_039104325.2 | 0.23 | 1 | 0.2 | 9.5e-19 | 5.22 | 1.81e-07 | 0.55 | FALSE |
| Brain | Lamp5 | gene expression | Lamp5 | 0.07 | 41 | 0.03 | 6.2e-04 | -5.68 | 1.34e-08 | 0.07 | FALSE |
| Brain | Plcb4 | gene expression | Plcb4 | 0.56 | 1 | 0.5 | 9.7e-53 | 5.21 | 1.90e-07 | 0.54 | TRUE |
| Brain | Plcb4 | isoform ratio | XM_006235085.5 | 0.21 | 87 | 0.14 | 4.0e-13 | 5.53 | 3.15e-08 | 0.58 | TRUE |
| Brain | Plcb1 | intron excision ratio | chr3_143138850_143150657 | 0.03 | 1107 | 0.03 | 1.3e-03 | 5.37 | 7.72e-08 | 0.25 | FALSE |
| Brain | Plcb1 | intron excision ratio | chr3_143138850_143222448 | 0.02 | 1107 | 0.01 | 2.3e-02 | -5.53 | 3.13e-08 | 0.33 | FALSE |
| Brain | Plcb4 | intron excision ratio | chr3_143493493_143559809 | 0.44 | 25 | 0.25 | 1.3e-23 | -5.25 | 1.54e-07 | 0.55 | FALSE |
| Brain | Plcb4 | intron excision ratio | chr3_143517457_143559809 | 0.02 | 1407 | 0.02 | 3.1e-03 | -5.27 | 1.40e-07 | 0.44 | FALSE |
| Brain | Plcb4 | intron excision ratio | chr3_143523533_143559809 | 0.5 | 1407 | 0.32 | 2.6e-30 | 5.56 | 2.64e-08 | 0.57 | FALSE |
| IC | Plcb4 | alternative TSS | XM_039104319.2 | 0.43 | 1 | 0.33 | 2.0e-14 | -5.29 | 1.22e-07 | 0.64 | FALSE |
| IC | Plcb4 | isoform ratio | XM_006235085.5 | 0.12 | 1 | 0.06 | 1.6e-03 | 5.3 | 1.14e-07 | 0.05 | FALSE |
| IC | Plcb4 | intron excision ratio | chr3_143493493_143559809 | 0.33 | 9 | 0.32 | 3.9e-14 | -5.29 | 1.26e-07 | 0.64 | TRUE |
| IL | Plcb1 | gene expression | Plcb1 | 0.22 | 1107 | 0.11 | 1.3e-03 | 5.36 | 8.12e-08 | 0.27 | FALSE |
| IL | Plcb4 | gene expression | Plcb4 | 0.56 | 1 | 0.3 | 6.7e-08 | 5.29 | 1.22e-07 | 0.32 | FALSE |
| LHb | Plcb4 | gene expression | Plcb4 | 0.31 | 1 | 0.14 | 2.9e-04 | 5.22 | 1.81e-07 | 0.06 | FALSE |
| Liver | Plcb1 | gene expression | Plcb1 | 0.05 | 33 | 0.04 | 5.8e-05 | 5.21 | 1.90e-07 | 0.24 | FALSE |
| Liver | Hao1 | mRNA stability | Hao1 | 0.39 | 47 | 0.27 | 9.0e-30 | -5.25 | 1.52e-07 | 0.14 | TRUE |
| NAcc | Plcb4 | alternative TSS | XM_039104319.2 | 0.08 | 1 | 0.06 | 2.7e-09 | -5.22 | 1.75e-07 | 0.56 | FALSE |
| NAcc | Plcb4 | alternative TSS | XM_039104319.2 | 0.06 | 1 | 0.05 | 6.6e-08 | -5.23 | 1.70e-07 | 0.56 | FALSE |
| NAcc | Plcb4 | gene expression | Plcb4 | 0.11 | 24 | 0.14 | 1.0e-20 | 5.44 | 5.31e-08 | 0.65 | FALSE |
| NAcc | Plcb1 | intron excision ratio | chr3_143138850_143222448 | 0.04 | 1 | 0.03 | 6.2e-05 | 5.62 | 1.91e-08 | 0.78 | FALSE |
| NAcc | Plcb4 | intron excision ratio | chr3_143493493_143559809 | 0.1 | 17 | 0.06 | 8.3e-09 | -5.28 | 1.28e-07 | 0.54 | FALSE |
| OFC | Plcb4 | gene expression | Plcb4 | 0.52 | 229 | 0.46 | 1.6e-12 | 5.46 | 4.77e-08 | 0.61 | FALSE |
| PL | Plcb4 | alternative TSS | XM_039104317.2 | 0.03 | 1 | 0.03 | 1.4e-04 | 5.27 | 1.37e-07 | 0.06 | FALSE |
| PL | Plcb4 | alternative TSS | XM_039104319.2 | 0.14 | 5 | 0.11 | 1.4e-11 | 5.35 | 8.97e-08 | 0.57 | FALSE |
| PL | Plcb4 | alternative TSS | XM_039104317.2 | 0.02 | 1 | 0.02 | 1.8e-03 | 5.22 | 1.75e-07 | 0.04 | FALSE |
| PL | Plcb4 | alternative TSS | XM_039104319.2 | 0.16 | 8 | 0.13 | 1.5e-13 | 5.47 | 4.56e-08 | 0.58 | FALSE |
| PL | Plcb4 | alternative TSS | XM_039104325.2 | 0.05 | 1 | 0.03 | 1.8e-04 | 5.22 | 1.81e-07 | 0.08 | FALSE |
| PL | Plcb1 | intron excision ratio | chr3_143138850_143150657 | 0.02 | 1107 | 0.01 | 9.9e-03 | 5.44 | 5.30e-08 | 0.26 | FALSE |
| PL | Plcb4 | intron excision ratio | chr3_143493493_143559809 | 0.16 | 1407 | 0.09 | 3.3e-10 | -6.02 | 1.73e-09 | 0.57 | FALSE |
| pVTA | Plcb4 | alternative TSS | XM_039104325.2 | 0.1 | 14 | 0.13 | 1.7e-10 | 5.42 | 5.97e-08 | 0.63 | FALSE |
| pVTA | Plcb4 | alternative TSS | XM_039104319.2 | 0.38 | 58 | 0.39 | 2.3e-33 | 5.4 | 6.67e-08 | 0.67 | FALSE |
| pVTA | Plcb4 | alternative TSS | XM_039104325.2 | 0.13 | 65 | 0.13 | 2.2e-10 | 5.37 | 7.89e-08 | 0.63 | FALSE |
| pVTA | Plcb4 | gene expression | Plcb4 | 0.1 | 1 | 0.06 | 1.5e-05 | 5.29 | 1.20e-07 | 0.43 | FALSE |
| pVTA | Plcb4 | isoform ratio | XM_063283134.1 | 0.08 | 1407 | 0.08 | 2.8e-07 | 6.07 | 1.26e-09 | 0.62 | FALSE |
| pVTA | Plcb4 | intron excision ratio | chr3_143517457_143559809 | 0.02 | 1 | 0.02 | 1.1e-02 | 5.33 | 1.00e-07 | 0.05 | FALSE |
| pVTA | Plcb4 | intron excision ratio | chr3_143523533_143559809 | 0.25 | 66 | 0.29 | 1.1e-23 | 5.36 | 8.52e-08 | 0.66 | FALSE |