Best TWAS P = 3.30e-11 · Best GWAS P= 5.94e-10 conditioned to 3.71e-01
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Rpp30 | isoform ratio | XM_063273886.1 | 0.2 | 2533 | 0.18 | 5.3e-20 | 5.28 | 1.29e-07 | 0 | FALSE |
| Adipose | Rpp30 | intron excision ratio | chr1_243209754_243216808 | 0.05 | 2533 | 0.03 | 1.3e-04 | -5.47 | 4.45e-08 | 0.45 | FALSE |
| BLA | Htr7 | isoform ratio | XM_039089833.2 | 0.14 | 112 | 0.02 | 2.0e-02 | -5.48 | 4.27e-08 | 0.22 | FALSE |
| BLA | Rpp30 | isoform ratio | XR_005492259.2 | 0.06 | 1 | 0.04 | 5.1e-03 | -6.12 | 9.24e-10 | 0.09 | FALSE |
| Brain | Pank1 | alternative TSS | NM_001106373.3 | 0.04 | 1 | 0.03 | 3.4e-04 | 5.35 | 8.99e-08 | 0.05 | FALSE |
| Brain | Pank1 | alternative TSS | NM_001106373.3 | 0.04 | 1 | 0.04 | 3.2e-04 | 5.35 | 8.99e-08 | 0.05 | FALSE |
| Brain | Rpp30 | alternative TSS | XM_039090942.2 | 0.06 | 10 | 0.02 | 2.6e-03 | -6.3 | 3.02e-10 | 0.62 | FALSE |
| Brain | Rpp30 | alternative TSS | XM_063273886.1 | 0.23 | 140 | 0.17 | 1.1e-15 | 5.75 | 8.88e-09 | 0 | FALSE |
| Brain | Htr7 | gene expression | Htr7 | 0.04 | 1 | 0.02 | 2.3e-03 | -5.97 | 2.35e-09 | 0.07 | FALSE |
| Brain | Rpp30 | isoform ratio | XM_039090942.2 | 0.05 | 17 | 0.02 | 1.1e-02 | -6.63 | 3.30e-11 | 0.66 | TRUE |
| Brain | Rpp30 | isoform ratio | XM_063273886.1 | 0.25 | 252 | 0.22 | 2.1e-20 | 6.11 | 1.01e-09 | 0.08 | FALSE |
| Brain | Rpp30 | intron excision ratio | chr1_243204233_243205243 | 0.03 | 1 | 0.01 | 1.5e-02 | -5.97 | 2.38e-09 | 0.04 | FALSE |
| Brain | Rpp30 | intron excision ratio | chr1_243204233_243209665 | 0.1 | 1 | 0.09 | 1.7e-08 | 6.01 | 1.81e-09 | 0.78 | FALSE |
| Brain | Rpp30 | intron excision ratio | chr1_243205398_243209665 | 0.08 | 1 | 0.06 | 3.4e-06 | -5.4 | 6.79e-08 | 0.08 | FALSE |
| IC | Htr7 | gene expression | Htr7 | 0.16 | 1 | 0.04 | 1.0e-02 | -5.97 | 2.35e-09 | 0.07 | FALSE |
| IC | Rpp30 | intron excision ratio | chr1_243205398_243209665 | 0.14 | 238 | 0.08 | 2.6e-04 | -5.83 | 5.49e-09 | 0.54 | FALSE |
| LHb | Pank1 | isoform ratio | XM_039109256.2 | 0.15 | 1 | 0.09 | 3.2e-03 | 5.87 | 4.26e-09 | 0.07 | FALSE |
| Liver | Rpp30 | alternative TSS | NM_001191083.1 | 0.05 | 2533 | 0.03 | 2.0e-04 | -6.16 | 7.33e-10 | 0.73 | FALSE |
| Liver | LOC134485229 | gene expression | LOC134485229 | 0.03 | 1 | 0.01 | 7.0e-03 | -6.1 | 1.04e-09 | 0.05 | FALSE |
| NAcc | LOC134485230 | gene expression | LOC134485230 | 0.07 | 24 | 0.06 | 9.8e-09 | -6.33 | 2.38e-10 | 0.2 | FALSE |
| NAcc | Rpp30 | intron excision ratio | chr1_243205398_243209665 | 0.03 | 3 | 0.04 | 4.7e-06 | -5.37 | 8.01e-08 | 0.66 | FALSE |
| OFC | Rpp30 | alternative TSS | XM_063273886.1 | 0.47 | 158 | 0.27 | 3.3e-07 | 5.99 | 2.11e-09 | 0.13 | FALSE |
| PL | Pank1 | alternative TSS | XM_039109256.2 | 0.03 | 2344 | 0.01 | 1.7e-02 | -5.4 | 6.83e-08 | 0.3 | FALSE |
| PL | Rpp30 | alternative TSS | XM_063273886.1 | 0.34 | 31 | 0.21 | 4.5e-22 | 6.61 | 3.73e-11 | 0.81 | FALSE |
| PL | LOC134485230 | gene expression | LOC134485230 | 0.12 | 2465 | 0.08 | 8.0e-09 | -5.6 | 2.11e-08 | 0 | FALSE |
| PL | Rpp30 | intron excision ratio | chr1_243204233_243209665 | 0.06 | 2533 | 0.04 | 4.5e-05 | 5.75 | 8.84e-09 | 0.81 | FALSE |
| PL | Rpp30 | intron excision ratio | chr1_243205398_243209665 | 0.07 | 1 | 0.04 | 3.0e-05 | -6.03 | 1.68e-09 | 0.45 | FALSE |
| pVTA | Htr7 | alternative TSS | NM_022938.2 | 0.04 | 1 | 0.02 | 4.8e-03 | 6.08 | 1.20e-09 | 0.1 | FALSE |
| pVTA | Rpp30 | intron excision ratio | chr1_243204233_243205243 | 0.05 | 1 | 0.05 | 7.2e-05 | -6.04 | 1.59e-09 | 0.39 | FALSE |
| pVTA | Rpp30 | intron excision ratio | chr1_243204233_243209665 | 0.1 | 1 | 0.1 | 1.9e-08 | 6.03 | 1.68e-09 | 0.79 | FALSE |
| pVTA | Rpp30 | intron excision ratio | chr1_243205398_243209665 | 0.07 | 2533 | 0.06 | 2.6e-05 | -5.34 | 9.20e-08 | 0.66 | FALSE |
| pVTA | Hectd2 | mRNA stability | Hectd2 | 0.2 | 1 | 0.05 | 4.1e-05 | -6.03 | 1.68e-09 | 0.48 | FALSE |