Best TWAS P=9.556492e-08 · Best GWAS P=7.418679e-07 conditioned to 0.004794007
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Crebbp | gene expression | ENSRNOG00000005330 | 0.10 | 0.03 | blup | 1769 | 0.04 | 4.4e-05 | 3.8 | 5.3 | 9.6e-08 | -0.46 | 0.53 | 0.16 | TRUE |
| 2 | PL | Slx4 | mRNA stability | ENSRNOG00000024445 | 0.18 | 0.15 | blup | 1646 | 0.15 | 1.2e-11 | -4.8 | 5.2 | 1.7e-07 | -0.93 | 0.18 | 0.82 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.