Best TWAS P = 1.24e-09 · Best GWAS P= 8.44e-10 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Cflar | alternative TSS | XM_063266583.1 | 0.06 | 1 | 0.04 | 2.8e-05 | 5.74 | 9.33e-09 | 0.61 | FALSE |
| Adipose | Casp8 | gene expression | Casp8 | 0.13 | 13 | 0.02 | 2.6e-03 | -5.51 | 3.62e-08 | 0.81 | FALSE |
| Adipose | Aox1 | isoform ratio | XR_594396.4 | 0.03 | 2577 | 0.02 | 5.3e-03 | 5.47 | 4.41e-08 | 0.64 | FALSE |
| Adipose | Cflar | isoform ratio | NM_001033864.4 | 0.03 | 1 | 0.02 | 1.8e-03 | 5.73 | 9.83e-09 | 0.19 | FALSE |
| Adipose | Cflar | isoform ratio | XR_010054556.1 | 0.03 | 1 | 0.02 | 3.5e-03 | -5.63 | 1.76e-08 | 0.11 | FALSE |
| BLA | Kctd18 | isoform ratio | XM_006244967.4 | 0.17 | 2588 | 0.09 | 2.3e-05 | -5.32 | 1.03e-07 | 0.22 | FALSE |
| BLA | Kctd18 | isoform ratio | XM_039083313.2 | 0.06 | 1 | 0.04 | 5.4e-03 | 5.72 | 1.04e-08 | 0.04 | FALSE |
| BLA | Kctd18 | intron excision ratio | chr9_67009283_67010030 | 0.09 | 2588 | 0.07 | 2.2e-04 | 5.76 | 8.23e-09 | 0.54 | FALSE |
| Brain | Cflar | alternative TSS | XM_063266583.1 | 0.07 | 2374 | 0.03 | 1.3e-03 | 5.35 | 8.76e-08 | 0.69 | FALSE |
| Brain | Spats2l | alternative TSS | XM_006244992.4 | 0.04 | 1 | 0.04 | 2.1e-04 | -6.08 | 1.24e-09 | 0.19 | TRUE |
| Brain | Spats2l | alternative TSS | XM_006244992.4 | 0.03 | 1 | 0.02 | 2.8e-03 | -6.08 | 1.24e-09 | 0.07 | FALSE |
| Brain | Aox4 | gene expression | Aox4 | 0.04 | 1 | 0.04 | 1.0e-04 | 5.58 | 2.45e-08 | 0.05 | FALSE |
| Brain | Nif3l1 | gene expression | Nif3l1 | 0.07 | 2347 | 0.02 | 2.2e-03 | 5.25 | 1.49e-07 | 0.76 | FALSE |
| Brain | Spats2l | isoform ratio | XM_006244992.4 | 0.03 | 1 | 0.03 | 1.1e-03 | -6.08 | 1.24e-09 | 0.08 | FALSE |
| Liver | Kctd18 | gene expression | Kctd18 | 0.05 | 2588 | 0.02 | 3.7e-03 | 5.68 | 1.33e-08 | 0.56 | FALSE |
| Liver | Kctd18 | intron excision ratio | chr9_67028839_67031148 | 0.02 | 1 | 0.02 | 1.0e-03 | -5.63 | 1.76e-08 | 0.03 | FALSE |
| Liver | Flacc1 | mRNA stability | Flacc1 | 0.04 | 1 | 0.03 | 1.8e-04 | 5.57 | 2.51e-08 | 0.24 | FALSE |
| NAcc | Maip1 | gene expression | Maip1 | 0.04 | 1 | 0.02 | 3.4e-04 | 6.07 | 1.27e-09 | 0.33 | FALSE |
| NAcc | Kctd18 | intron excision ratio | chr9_67009283_67010966 | 0.08 | 35 | 0.03 | 5.9e-05 | -5.55 | 2.82e-08 | 0.19 | FALSE |
| PL | Kctd18 | isoform ratio | XM_006244967.4 | 0.05 | 29 | 0.04 | 2.7e-05 | -5.49 | 4.08e-08 | 0.44 | FALSE |
| PL | Spats2l | isoform ratio | XM_006244992.4 | 0.02 | 2517 | 0.02 | 3.6e-03 | -5.28 | 1.28e-07 | 0.33 | FALSE |
| PL | Kctd18 | intron excision ratio | chr9_67009283_67011591 | 0.03 | 2588 | 0.01 | 8.8e-03 | -5.74 | 9.58e-09 | 0.57 | FALSE |
| pVTA | Kctd18 | isoform ratio | XM_039083314.2 | 0.04 | 14 | 0.03 | 1.8e-03 | 5.55 | 2.90e-08 | 0.27 | FALSE |