Best TWAS P = 8.68e-08 · Best GWAS P= 8.16e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| IC | Mcee | intron excision ratio | chr1_127386686_127399268 | 0.26 | 1 | 0.22 | 1.2e-09 | 5.33 | 1.00e-07 | 0.84 | FALSE |
| NAcc | Fan1 | alternative polyA | NM_001191633.1 | 0.2 | 12 | 0.17 | 2.1e-25 | 5.26 | 1.47e-07 | 0.62 | FALSE |
| NAcc | Fan1 | alternative polyA | XM_039079939.2 | 0.2 | 12 | 0.17 | 2.0e-25 | -5.27 | 1.40e-07 | 0.62 | FALSE |
| NAcc | Fan1 | isoform ratio | XM_006229339.5 | 0.18 | 1 | 0.06 | 2.7e-09 | 5.26 | 1.45e-07 | 0.78 | FALSE |
| NAcc | Mcee | intron excision ratio | chr1_127376528_127386349 | 0.11 | 1 | 0.04 | 2.4e-07 | 5.25 | 1.55e-07 | 0.77 | FALSE |
| PL | Fan1 | isoform ratio | XM_006229339.5 | 0.11 | 1 | 0.08 | 3.6e-09 | 5.35 | 8.68e-08 | 0.86 | TRUE |
| pVTA | Mcee | intron excision ratio | chr1_127386686_127398569 | 0.09 | 1 | 0.07 | 4.5e-06 | 5.33 | 1.00e-07 | 0.77 | FALSE |