Best TWAS P=9.23029e-10 · Best GWAS P=2.305475e-08 conditioned to 1.920555e-35
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Htr7 | gene expression | ENSRNOG00000018827 | 0.09 | 0.05 | blup | 2536 | 0.05 | 7.8e-06 | -5.1 | -5.6 | 2.7e-08 | -0.47 | 0.68 | 0.32 | FALSE |
| 2 | BLA | Htr7 | isoform ratio | ENSRNOT00000025450 | 0.08 | 0.05 | top1 | 1 | 0.06 | 6.9e-04 | 5.4 | 5.4 | 5.7e-08 | 0.91 | 0.10 | 0.09 | FALSE |
| 3 | BLA | Htr7 | isoform ratio | ENSRNOT00000025493 | 0.06 | 0.04 | top1 | 1 | 0.04 | 5.0e-03 | 5.4 | -5.4 | 6.6e-08 | -0.95 | 0.10 | 0.05 | FALSE |
| 4 | Brain | NA | gene expression | ENSRNOG00000064807 | 0.09 | 0.02 | enet | 54 | 0.05 | 1.2e-05 | 4.3 | -6.1 | 9.2e-10 | -0.64 | 0.35 | 0.64 | TRUE |
| 5 | Brain | Rpp30 | intron excision ratio | chr1:233791632:233797064 | 0.08 | 0.08 | top1 | 1 | 0.08 | 3.6e-08 | 5.4 | 5.4 | 8.0e-08 | 0.97 | 0.28 | 0.71 | FALSE |
| 6 | Brain | Rpp30 | mRNA stability | ENSRNOG00000018718 | 0.09 | 0.10 | top1 | 1 | 0.10 | 8.3e-10 | 5.2 | -5.2 | 1.6e-07 | -0.95 | 0.44 | 0.56 | FALSE |
| 7 | Liver | Rpp30 | mRNA stability | ENSRNOG00000018718 | 0.09 | 0.03 | blup | 2475 | 0.06 | 8.9e-07 | 5.4 | -5.9 | 4.1e-09 | -0.75 | 0.37 | 0.63 | FALSE |
| 8 | PL | NA | gene expression | ENSRNOG00000064807 | 0.12 | 0.05 | lasso | 4 | 0.06 | 1.3e-05 | -5.1 | -5.4 | 7.0e-08 | -0.09 | 0.56 | 0.42 | FALSE |
| 9 | PL | Rpp30 | mRNA stability | ENSRNOG00000018718 | 0.20 | 0.08 | top1 | 1 | 0.08 | 1.4e-06 | 5.3 | -5.3 | 1.5e-07 | -0.98 | 0.35 | 0.48 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.