Best TWAS P = 3.96e-12 · Best GWAS P= 4.47e-12 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Kansl1l | alternative TSS | XM_063268145.1 | 0.11 | 24 | 0.03 | 3.6e-04 | 5.55 | 2.86e-08 | 0.48 | FALSE |
| Adipose | Kansl1l | alternative TSS | XM_063268145.1 | 0.11 | 2553 | 0.03 | 5.8e-04 | 5.81 | 6.13e-09 | 0.4 | FALSE |
| Adipose | Kansl1l | isoform ratio | XM_063268151.1 | 0.07 | 2553 | 0.01 | 4.5e-02 | 5.8 | 6.45e-09 | 0.36 | FALSE |
| Adipose | Kansl1l | intron excision ratio | chr9_75749932_75756280 | 0.15 | 1 | 0.05 | 1.5e-06 | -5.25 | 1.50e-07 | 0.01 | FALSE |
| BLA | Map2 | alternative polyA | XM_063266724.1 | 0.28 | 15 | 0.13 | 1.9e-07 | 6.94 | 3.96e-12 | 0.94 | TRUE |
| BLA | Lancl1 | gene expression | Lancl1 | 0.38 | 8 | 0.32 | 2.4e-17 | 5.6 | 2.13e-08 | 0.24 | FALSE |
| BLA | Map2 | mRNA stability | Map2 | 0.39 | 12 | 0.26 | 4.5e-14 | 6.07 | 1.27e-09 | 0.87 | FALSE |
| Brain | Map2 | alternative polyA | NM_013066.1 | 0.47 | 1 | 0.31 | 5.8e-29 | -6.85 | 7.61e-12 | 0.97 | FALSE |
| Brain | Map2 | alternative polyA | XM_063266724.1 | 0.47 | 29 | 0.3 | 3.6e-28 | 6.53 | 6.55e-11 | 0.95 | FALSE |
| Brain | Lancl1 | gene expression | Lancl1 | 0.3 | 48 | 0.56 | 2.8e-63 | 5.3 | 1.16e-07 | 0 | FALSE |
| Brain | LOC134480382 | gene expression | LOC134480382 | 0.03 | 15 | 0.01 | 6.5e-02 | -5.29 | 1.24e-07 | 0.09 | FALSE |
| Brain | Kansl1l | isoform ratio | XM_063268155.1 | 0.06 | 2553 | 0.02 | 4.8e-03 | 5.28 | 1.30e-07 | 0.04 | FALSE |
| Brain | Lancl1 | mRNA stability | Lancl1 | 0.07 | 1 | 0.06 | 1.3e-06 | 5.35 | 8.98e-08 | 0.01 | FALSE |
| IC | Lancl1 | gene expression | Lancl1 | 0.41 | 47 | 0.47 | 3.3e-22 | 5.33 | 9.99e-08 | 0 | FALSE |
| IC | Rpe | intron excision ratio | chr9_75641185_75647027 | 0.12 | 28 | 0.1 | 5.6e-05 | 6.53 | 6.49e-11 | 0.82 | FALSE |
| IL | Map2 | mRNA stability | Map2 | 0.23 | 2703 | 0.05 | 2.5e-02 | 5.7 | 1.21e-08 | 0.7 | FALSE |
| Liver | Lancl1 | gene expression | Lancl1 | 0.6 | 1 | 0.34 | 2.0e-39 | 5.21 | 1.87e-07 | 0 | FALSE |
| NAcc | Map2 | alternative polyA | XM_063266724.1 | 0.04 | 2703 | 0.01 | 3.3e-02 | 6.03 | 1.61e-09 | 0.85 | FALSE |
| NAcc | Lancl1 | alternative TSS | NM_053723.1 | 0.02 | 1 | 0.01 | 1.8e-03 | -5.29 | 1.20e-07 | 0.02 | FALSE |
| NAcc | Lancl1 | isoform ratio | NM_053723.1 | 0.02 | 1 | 0.02 | 1.5e-03 | -5.29 | 1.20e-07 | 0.02 | FALSE |
| NAcc | Map2 | mRNA stability | Map2 | 0.33 | 51 | 0.25 | 3.1e-37 | 5.24 | 1.61e-07 | 0.73 | FALSE |
| PL | Kansl1l | alternative TSS | XM_063268146.1 | 0.02 | 12 | 0.02 | 2.6e-03 | -5.95 | 2.67e-09 | 0.5 | FALSE |
| PL | Lancl1 | gene expression | Lancl1 | 0.29 | 15 | 0.34 | 3.1e-38 | 5.39 | 7.03e-08 | 0.01 | FALSE |
| PL | Unc80 | gene expression | Unc80 | 0.06 | 2475 | 0.02 | 1.8e-03 | -5.2 | 1.95e-07 | 0.21 | FALSE |
| PL | Rpe | intron excision ratio | chr9_75647106_75651469 | 0.08 | 122 | 0.05 | 2.7e-06 | 5.47 | 4.40e-08 | 0 | FALSE |
| pVTA | Acadl | gene expression | Acadl | 0.11 | 24 | 0.12 | 4.9e-10 | 5.59 | 2.23e-08 | 0.23 | FALSE |
| pVTA | Unc80 | intron excision ratio | chr9_75626124_75633223 | 0.05 | 1 | 0.05 | 1.3e-04 | -5.29 | 1.20e-07 | 0.02 | FALSE |
| pVTA | Cps1 | mRNA stability | Cps1 | 0.03 | 2402 | 0.03 | 3.5e-03 | -5.23 | 1.68e-07 | 0.71 | FALSE |