Best TWAS P=1.31e-08 · Best GWAS P=4.07e-06 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Gnl1 | gene expression | Gnl1 | 0.07 | 8 | 0.06 | 1.8e-07 | -5.28 | 1.26e-07 | 0.72 | FALSE |
| Adipose | LOC120093125 | intron excision ratio | chr20_2624215_2624418 | 0.46 | 903 | 0.08 | 2.5e-09 | -5.18 | 2.22e-07 | 0.76 | FALSE |
| Adipose | RT1-T24-4 | intron excision ratio | chr20_2691672_2691881 | 0.49 | 1129 | 0.07 | 3.2e-08 | 5.24 | 1.64e-07 | 0.73 | FALSE |
| BLA | Abcf1 | gene expression | Abcf1 | 0.56 | 1268 | 0.3 | 2.0e-16 | -5.4 | 6.80e-08 | 0.68 | TRUE |
| BLA | Dhx16 | gene expression | Dhx16 | 0.12 | 1315 | 0.06 | 3.1e-04 | -5.42 | 6.10e-08 | 0.65 | FALSE |
| BLA | RT1-T24-2 | gene expression | RT1-T24-2 | 0.23 | 1239 | 0.17 | 1.6e-09 | -5.22 | 1.80e-07 | 0.7 | FALSE |
| Brain | Dhx16 | alternative polyA | XM_039098481.1 | 0.22 | 1315 | 0.13 | 5.7e-12 | 5.32 | 1.06e-07 | 0.7 | FALSE |
| Brain | LOC120093125 | alternative polyA | XM_039099257.1 | 0.17 | 948 | 0.14 | 5.8e-13 | -5.25 | 1.55e-07 | 0.74 | FALSE |
| Brain | LOC120093125 | alternative polyA | XM_039099257.1 | 0.17 | 948 | 0.14 | 1.3e-12 | -5.25 | 1.55e-07 | 0.74 | FALSE |
| Brain | RT1-S3 | isoform ratio | NM_001008886.2 | 0.05 | 1120 | 0.04 | 1.7e-04 | -5.19 | 2.11e-07 | 0.65 | FALSE |
| Brain | RT1-S3 | isoform ratio | XM_006255917.4 | 0.05 | 1120 | 0.04 | 1.4e-04 | 5.18 | 2.25e-07 | 0.64 | FALSE |
| Eye | LOC120093125 | isoform ratio | XM_039099255.1 | 0.42 | 33 | 0.13 | 5.6e-03 | -5.18 | 2.24e-07 | 0.2 | FALSE |
| IL | LOC120093125 | alternative polyA | XM_039099255.1 | 0.4 | 948 | 0.17 | 6.9e-05 | 5.21 | 1.87e-07 | 0.68 | FALSE |
| IL | LOC120093125 | isoform ratio | XM_039099257.1 | 0.31 | 948 | 0.21 | 7.1e-06 | -5.22 | 1.81e-07 | 0.68 | FALSE |
| IL | RT1-N2 | isoform ratio | XM_039098786.1 | 0.64 | 10 | 0.36 | 1.2e-09 | 5.23 | 1.71e-07 | 0.72 | FALSE |
| Liver | LOC120093125 | alternative polyA | XM_039099257.1 | 0.41 | 160 | 0.19 | 6.2e-21 | 5.24 | 1.57e-07 | 0.76 | FALSE |
| Liver | Prr3 | isoform ratio | XM_006255942.3 | 0.02 | 20 | 0.02 | 3.9e-03 | 5.31 | 1.08e-07 | 0.5 | FALSE |
| Liver | RT1-N2 | isoform ratio | XM_039098783.1 | 0.3 | 34 | 0.29 | 2.4e-32 | 5.22 | 1.77e-07 | 0.75 | FALSE |
| Liver | RT1-T24-4 | intron excision ratio | chr20_2741803_2741939 | 0.19 | 1129 | 0.03 | 7.2e-04 | -5.24 | 1.63e-07 | 0.66 | FALSE |
| NAcc | Dhx16 | alternative polyA | XM_039098481.1 | 0.14 | 1315 | 0.06 | 5.3e-08 | 5.68 | 1.31e-08 | 0.69 | TRUE |
| NAcc | RT1-N3 | alternative TSS | XM_039098420.1 | 0.19 | 32 | 0.17 | 1.4e-19 | -5.21 | 1.85e-07 | 0.71 | FALSE |
| NAcc | RT1-N3 | alternative TSS | NM_001008855.2 | 0.22 | 19 | 0.23 | 7.5e-27 | 5.23 | 1.67e-07 | 0.73 | FALSE |
| NAcc | RT1-N3 | alternative TSS | XM_039098421.1 | 0.08 | 40 | 0.07 | 9.0e-09 | 5.19 | 2.14e-07 | 0.72 | FALSE |
| NAcc | RT1-N3 | isoform ratio | XM_039098420.1 | 0.27 | 17 | 0.24 | 2.7e-27 | -5.23 | 1.70e-07 | 0.71 | FALSE |
| OFC | RT1-N2 | alternative polyA | XM_017601671.2 | 0.43 | 999 | 0.3 | 6.7e-08 | 5.21 | 1.87e-07 | 0.72 | FALSE |
| OFC | RT1-N3 | isoform ratio | XM_006255908.4 | 0.23 | 1052 | 0.09 | 4.4e-03 | 5.18 | 2.24e-07 | 0.54 | FALSE |
| PL | RT1-N3 | alternative TSS | XM_039098420.1 | 0.23 | 20 | 0.27 | 3.7e-29 | -5.24 | 1.61e-07 | 0.69 | TRUE |
| PL | RT1-N3 | alternative TSS | NM_001008855.2 | 0.12 | 1052 | 0.11 | 4.7e-12 | 5.23 | 1.71e-07 | 0.72 | FALSE |
| pVTA | Abcf1 | isoform ratio | NM_001109883.2 | 0.15 | 1268 | 0.06 | 1.4e-03 | 5.22 | 1.80e-07 | 0.62 | FALSE |
| pVTA | Abcf1 | isoform ratio | XM_017601783.2 | 0.13 | 1268 | 0.05 | 3.1e-03 | -5.22 | 1.80e-07 | 0.58 | FALSE |