Best TWAS P=1.503648e-07 · Best GWAS P=1.835686e-06 conditioned to 0.5560687
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Eye | Plcb4 | alternative TSS | ENSRNOT00000042853 | 0.51 | 0.13 | enet | 150 | 0.15 | 0.0024 | -4.6 | 5.3 | 1.5e-07 | -0.85 | 0.19 | 0.18 | TRUE |
2 | Eye | Plcb4 | alternative TSS | ENSRNOT00000105709 | 0.67 | 0.04 | enet | 130 | 0.10 | 0.0120 | -4.6 | -5.3 | 1.5e-07 | 0.80 | 0.17 | 0.15 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.