Best TWAS P = 6.77e-10 · Best GWAS P= 3.40e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Mertk | alternative polyA | NM_022943.1 | 0.04 | 30 | 0.02 | 1.5e-03 | 5.41 | 6.27e-08 | 0.35 | FALSE |
| Adipose | Mertk | alternative polyA | XM_063284527.1 | 0.04 | 42 | 0.02 | 1.1e-03 | -5.38 | 7.56e-08 | 0.35 | FALSE |
| Adipose | Pced1a | alternative polyA | NM_001399286.1 | 0.05 | 1479 | 0.03 | 3.0e-04 | 5.29 | 1.19e-07 | 0.45 | FALSE |
| Adipose | Zc3h8 | alternative TSS | XM_063283755.1 | 0.05 | 2243 | 0.03 | 7.3e-04 | -5.29 | 1.20e-07 | 0.43 | FALSE |
| Adipose | Zc3h8 | alternative TSS | XM_063283755.1 | 0.04 | 2243 | 0.02 | 5.5e-03 | -5.23 | 1.70e-07 | 0.4 | FALSE |
| Adipose | LOC129351010 | gene expression | LOC129351010 | 0.04 | 1529 | 0.02 | 1.5e-03 | 5.28 | 1.33e-07 | 0.4 | FALSE |
| Adipose | Mrps26 | gene expression | Mrps26 | 0.04 | 1 | 0.02 | 2.3e-03 | -5.25 | 1.54e-07 | 0.03 | FALSE |
| Adipose | Pced1a | gene expression | Pced1a | 0.05 | 1479 | 0.03 | 1.0e-04 | -5.28 | 1.28e-07 | 0.45 | FALSE |
| Adipose | Ttl | gene expression | Ttl | 0.31 | 156 | 0.21 | 2.5e-23 | 5.45 | 5.12e-08 | 0.62 | FALSE |
| Adipose | Ubox5 | gene expression | Ubox5 | 0.12 | 839 | 0.08 | 6.9e-09 | -5.25 | 1.51e-07 | 0.55 | FALSE |
| Adipose | Mertk | isoform ratio | NM_022943.1 | 0.03 | 1 | 0.01 | 8.3e-03 | 5.35 | 8.60e-08 | 0.04 | FALSE |
| Adipose | Mertk | isoform ratio | XM_063284527.1 | 0.04 | 2143 | 0.02 | 6.3e-03 | -5.39 | 7.12e-08 | 0.37 | FALSE |
| Adipose | Zc3h8 | isoform ratio | XM_063283755.1 | 0.06 | 1 | 0.03 | 2.3e-04 | -5.44 | 5.18e-08 | 0.35 | FALSE |
| Adipose | Fastkd5 | intron excision ratio | chr3_138286180_138299471 | 0.03 | 1 | 0.01 | 6.2e-02 | 5.27 | 1.40e-07 | 0.03 | FALSE |
| Adipose | Ubox5 | intron excision ratio | chr3_138286180_138299471 | 0.03 | 1 | 0.01 | 6.2e-02 | 5.27 | 1.40e-07 | 0.03 | FALSE |
| Adipose | Ubox5 | mRNA stability | Ubox5 | 0.04 | 839 | 0.02 | 1.0e-03 | -5.26 | 1.41e-07 | 0.51 | FALSE |
| BLA | Zc3h6 | alternative polyA | NM_001107772.1 | 0.73 | 2241 | 0.49 | 6.9e-29 | -5.32 | 1.06e-07 | 0.42 | FALSE |
| BLA | Zc3h6 | alternative polyA | XM_008762235.4 | 0.76 | 439 | 0.49 | 1.7e-29 | 5.23 | 1.68e-07 | 0.42 | FALSE |
| BLA | Zc3h6 | alternative TSS | XM_008762235.4 | 0.11 | 103 | 0.05 | 1.2e-03 | -5.24 | 1.58e-07 | 0.36 | TRUE |
| BLA | Zc3h8 | alternative TSS | XM_063283755.1 | 0.23 | 21 | 0.09 | 1.2e-05 | -5.45 | 5.15e-08 | 0.47 | FALSE |
| BLA | Zc3h8 | alternative TSS | XM_063283754.1 | 0.22 | 138 | 0.09 | 1.1e-05 | 5.47 | 4.43e-08 | 0.47 | FALSE |
| BLA | Zc3h8 | alternative TSS | XM_063283755.1 | 0.24 | 241 | 0.1 | 7.5e-06 | -5.47 | 4.53e-08 | 0.48 | FALSE |
| BLA | Mrps26 | gene expression | Mrps26 | 0.14 | 1 | 0.08 | 5.1e-05 | -5.23 | 1.74e-07 | 0.06 | FALSE |
| BLA | Vinac1 | gene expression | Vinac1 | 0.28 | 101 | 0.23 | 3.0e-12 | 5.24 | 1.59e-07 | 0.54 | FALSE |
| BLA | Zc3h6 | isoform ratio | NM_001107772.1 | 0.18 | 2241 | 0.12 | 4.0e-07 | -5.28 | 1.27e-07 | 0.46 | FALSE |
| BLA | Zc3h8 | isoform ratio | XM_063283755.1 | 0.21 | 159 | 0.09 | 1.4e-05 | -5.33 | 1.00e-07 | 0.43 | FALSE |
| BLA | Pced1a | intron excision ratio | chr3_138070549_138070844 | 0.05 | 1479 | 0.03 | 1.2e-02 | -5.29 | 1.20e-07 | 0.3 | FALSE |
| BLA | Ubox5 | intron excision ratio | chr3_138265592_138268276 | 0.08 | 13 | 0.03 | 6.6e-03 | 5.26 | 1.41e-07 | 0.32 | FALSE |
| BLA | Zc3h8 | intron excision ratio | chr3_136643995_136645773 | 0.15 | 35 | 0.07 | 2.0e-04 | -5.52 | 3.30e-08 | 0.46 | FALSE |
| Brain | Pced1a | alternative polyA | XM_039104578.2 | 0.31 | 78 | 0.41 | 1.9e-40 | 5.29 | 1.20e-07 | 0.47 | FALSE |
| Brain | Pced1a | alternative polyA | XM_006235015.4 | 0.09 | 1 | 0.11 | 3.0e-10 | -5.23 | 1.66e-07 | 0.43 | FALSE |
| Brain | Pced1a | alternative polyA | XM_039104578.2 | 0.31 | 37 | 0.41 | 1.0e-40 | 5.35 | 8.94e-08 | 0.48 | FALSE |
| Brain | Pced1a | alternative TSS | NM_001399286.1 | 0.03 | 1 | 0.03 | 1.8e-03 | -5.26 | 1.45e-07 | 0.04 | FALSE |
| Brain | Pced1a | alternative TSS | NM_001399286.1 | 0.04 | 1479 | 0.04 | 1.1e-04 | -5.22 | 1.79e-07 | 0.45 | FALSE |
| Brain | Ebf4 | gene expression | Ebf4 | 0.21 | 1683 | 0.18 | 2.1e-16 | 5.3 | 1.14e-07 | 0.46 | FALSE |
| Brain | LOC134486151 | gene expression | LOC134486151 | 0.03 | 1 | 0.03 | 1.4e-03 | 5.24 | 1.63e-07 | 0.04 | FALSE |
| Brain | Ttl | gene expression | Ttl | 0.07 | 121 | 0.03 | 1.9e-03 | 5.36 | 8.49e-08 | 0.55 | FALSE |
| Brain | Ubox5 | gene expression | Ubox5 | 0.13 | 839 | 0.12 | 4.1e-11 | -5.27 | 1.40e-07 | 0.56 | FALSE |
| Brain | Ubox5 | intron excision ratio | chr3_138271085_138272928 | 0.75 | 57 | 0.79 | 3.2e-116 | 5.21 | 1.93e-07 | 0.49 | FALSE |
| Brain | Ebf4 | mRNA stability | Ebf4 | 0.2 | 16 | 0.19 | 7.1e-18 | 5.28 | 1.30e-07 | 0.46 | FALSE |
| Eye | Ubox5 | intron excision ratio | chr3_138271085_138272928 | 0.83 | 1 | 0.39 | 5.4e-07 | 5.22 | 1.81e-07 | 0.07 | FALSE |
| IC | Ttl | alternative TSS | NM_138536.2 | 0.32 | 16 | 0.24 | 1.4e-10 | -5.24 | 1.60e-07 | 0.51 | FALSE |
| IC | Ttl | alternative TSS | XM_039104213.2 | 0.32 | 11 | 0.24 | 1.8e-10 | 5.25 | 1.55e-07 | 0.51 | FALSE |
| IC | Fbln7 | gene expression | Fbln7 | 0.29 | 2289 | 0.18 | 3.7e-08 | -5.31 | 1.12e-07 | 0.42 | FALSE |
| IC | LOC108350462 | gene expression | LOC108350462 | 0.15 | 112 | 0.09 | 1.1e-04 | 5.27 | 1.40e-07 | 0.38 | FALSE |
| IC | Pced1a | isoform ratio | XM_039104578.2 | 0.32 | 184 | 0.41 | 2.7e-18 | 5.33 | 9.56e-08 | 0.46 | FALSE |
| IC | Ubox5 | intron excision ratio | chr3_138271085_138272928 | 0.93 | 1 | 0.73 | 4.2e-43 | 5.23 | 1.73e-07 | 0.51 | FALSE |
| IC | Ubox5 | intron excision ratio | chr3_138271085_138272979 | 0.93 | 1 | 0.73 | 3.4e-43 | -5.23 | 1.73e-07 | 0.51 | FALSE |
| IL | Pced1a | alternative polyA | XM_039104578.2 | 0.55 | 1479 | 0.34 | 4.3e-09 | 5.22 | 1.78e-07 | 0.46 | FALSE |
| IL | Zc3h6 | alternative polyA | XM_008762235.4 | 0.78 | 15 | 0.44 | 4.7e-12 | 5.25 | 1.48e-07 | 0.4 | FALSE |
| IL | Ubox5 | gene expression | Ubox5 | 0.27 | 839 | 0.11 | 1.1e-03 | -5.26 | 1.42e-07 | 0.44 | FALSE |
| LHb | Fbln7 | gene expression | Fbln7 | 0.42 | 2289 | 0.12 | 9.6e-04 | -5.28 | 1.33e-07 | 0.39 | FALSE |
| LHb | Mrps26 | gene expression | Mrps26 | 0.23 | 1053 | 0.13 | 5.1e-04 | -5.26 | 1.47e-07 | 0.43 | FALSE |
| LHb | Tgm6 | gene expression | Tgm6 | 0.22 | 339 | 0.14 | 4.0e-04 | -6.17 | 6.77e-10 | 0.37 | TRUE |
| LHb | Ttl | gene expression | Ttl | 0.24 | 14 | 0.07 | 7.6e-03 | -5.24 | 1.60e-07 | 0.3 | FALSE |
| LHb | Ubox5 | gene expression | Ubox5 | 0.25 | 839 | 0.11 | 1.3e-03 | -5.25 | 1.55e-07 | 0.49 | FALSE |
| Liver | Zc3h6 | alternative polyA | NM_001107772.1 | 0.15 | 9 | 0.07 | 4.9e-08 | -5.44 | 5.23e-08 | 0.41 | TRUE |
| Liver | Zc3h6 | alternative polyA | XM_008762235.4 | 0.14 | 11 | 0.07 | 6.2e-08 | 5.44 | 5.23e-08 | 0.41 | FALSE |
| Liver | Ebf4 | alternative TSS | XM_063284541.1 | 0.04 | 1 | 0.03 | 3.8e-04 | 5.31 | 1.10e-07 | 0.1 | FALSE |
| Liver | Ebf4 | gene expression | Ebf4 | 0.48 | 1 | 0.44 | 1.6e-53 | -5.26 | 1.47e-07 | 0.44 | FALSE |
| Liver | Fastkd5 | gene expression | Fastkd5 | 0.03 | 839 | 0.01 | 2.6e-02 | 5.27 | 1.34e-07 | 0.32 | FALSE |
| Liver | LOC108350462 | gene expression | LOC108350462 | 0.09 | 32 | 0.07 | 1.5e-08 | 5.24 | 1.57e-07 | 0.42 | TRUE |
| Liver | Pced1a | gene expression | Pced1a | 0.22 | 1 | 0.19 | 3.6e-21 | -5.33 | 9.85e-08 | 0.55 | FALSE |
| Liver | Polr1b | gene expression | Polr1b | 0.23 | 1 | 0.13 | 2.5e-14 | 5.5 | 3.88e-08 | 0.94 | FALSE |
| Liver | Ptpra | gene expression | Ptpra | 0.02 | 1376 | 0 | 8.6e-02 | -5.23 | 1.74e-07 | 0.33 | FALSE |
| Liver | Vps16 | gene expression | Vps16 | 0.17 | 7 | 0.13 | 9.2e-15 | -5.21 | 1.87e-07 | 0.45 | FALSE |
| Liver | Ubox5 | intron excision ratio | chr3_138271085_138272928 | 0.72 | 52 | 0.35 | 1.7e-40 | 5.24 | 1.61e-07 | 0.55 | FALSE |
| Liver | Ubox5 | intron excision ratio | chr3_138271085_138272979 | 0.72 | 48 | 0.35 | 2.3e-40 | -5.24 | 1.61e-07 | 0.55 | FALSE |
| Liver | Zc3h8 | intron excision ratio | chr3_136643995_136645773 | 0.04 | 1 | 0.02 | 3.8e-03 | -5.44 | 5.18e-08 | 0.07 | FALSE |
| Liver | Ubox5 | mRNA stability | Ubox5 | 0.12 | 839 | 0.07 | 6.4e-08 | -5.23 | 1.68e-07 | 0.55 | FALSE |
| NAcc | Pced1a | alternative polyA | XM_039104578.2 | 0.31 | 65 | 0.42 | 1.1e-68 | 5.28 | 1.32e-07 | 0.54 | FALSE |
| NAcc | Pced1a | alternative polyA | XM_039104578.2 | 0.34 | 84 | 0.41 | 5.7e-67 | 5.28 | 1.27e-07 | 0.54 | FALSE |
| NAcc | Sirpa | alternative TSS | NM_013016.3 | 0.03 | 1 | 0.03 | 7.9e-06 | -5.28 | 1.31e-07 | 0.65 | FALSE |
| NAcc | Sirpa | alternative TSS | NM_013016.3 | 0.02 | 1 | 0.02 | 1.8e-04 | -5.28 | 1.31e-07 | 0.22 | FALSE |
| NAcc | Ttl | alternative TSS | NM_138536.2 | 0.06 | 4 | 0.04 | 1.3e-06 | -5.5 | 3.88e-08 | 0.56 | FALSE |
| NAcc | Ttl | alternative TSS | XM_039104213.2 | 0.06 | 5 | 0.04 | 6.2e-07 | 5.5 | 3.74e-08 | 0.56 | FALSE |
| NAcc | Ebf4 | gene expression | Ebf4 | 0.07 | 4 | 0.05 | 1.9e-08 | 5.25 | 1.51e-07 | 0.42 | FALSE |
| NAcc | Fbln7 | gene expression | Fbln7 | 0.21 | 2289 | 0.21 | 6.2e-31 | -5.23 | 1.71e-07 | 0.49 | FALSE |
| NAcc | Ptpra | gene expression | Ptpra | 0.04 | 1376 | 0.06 | 2.3e-09 | -5.24 | 1.64e-07 | 0.48 | FALSE |
| NAcc | Ubox5 | gene expression | Ubox5 | 0.1 | 839 | 0.12 | 1.2e-17 | -5.28 | 1.29e-07 | 0.55 | FALSE |
| NAcc | Pced1a | isoform ratio | NM_001399285.1 | 0.01 | 1479 | 0.01 | 9.1e-03 | 5.23 | 1.69e-07 | 0.39 | FALSE |
| NAcc | Pced1a | isoform ratio | XM_039104578.2 | 0.21 | 1 | 0.36 | 1.8e-56 | 5.28 | 1.31e-07 | 0.49 | FALSE |
| NAcc | Zc3h8 | isoform ratio | XM_063283754.1 | 0.03 | 31 | 0.02 | 5.6e-04 | 5.29 | 1.25e-07 | 0.45 | TRUE |
| NAcc | Sirpa | intron excision ratio | chr3_137290101_137294612 | 0.04 | 1 | 0.04 | 1.7e-07 | 5.27 | 1.34e-07 | 0.75 | FALSE |
| NAcc | Ubox5 | intron excision ratio | chr3_138261254_138268276 | 0.02 | 839 | 0.01 | 3.6e-03 | -5.26 | 1.46e-07 | 0.43 | FALSE |
| NAcc | Ubox5 | intron excision ratio | chr3_138271085_138272928 | 0.52 | 145 | 0.61 | 3.3e-119 | 5.27 | 1.34e-07 | 0.6 | FALSE |
| NAcc | Ubox5 | intron excision ratio | chr3_138271085_138272979 | 0.51 | 122 | 0.61 | 3.9e-118 | -5.27 | 1.36e-07 | 0.6 | FALSE |
| NAcc | Pced1a | mRNA stability | Pced1a | 0.1 | 1 | 0.16 | 4.7e-24 | -5.27 | 1.38e-07 | 0.47 | FALSE |
| NAcc | Ttl | mRNA stability | Ttl | 0.04 | 2144 | 0.03 | 1.1e-05 | 5.21 | 1.90e-07 | 0.52 | FALSE |
| OFC | Pdyn | gene expression | Pdyn | 0.52 | 2304 | 0.4 | 1.3e-10 | 5.25 | 1.56e-07 | 0.55 | FALSE |
| OFC | LOC108350462 | isoform ratio | XR_005502459.2 | 0.25 | 82 | 0.17 | 8.2e-05 | -5.9 | 3.72e-09 | 0.36 | FALSE |
| OFC | Pced1a | mRNA stability | Pced1a | 0.24 | 1479 | 0.17 | 6.7e-05 | -5.27 | 1.37e-07 | 0.43 | FALSE |
| PL | Pced1a | alternative polyA | XM_006235015.4 | 0.16 | 1479 | 0.23 | 4.1e-25 | -5.21 | 1.85e-07 | 0.45 | FALSE |
| PL | Pced1a | alternative polyA | XM_039104578.2 | 0.57 | 78 | 0.52 | 9.3e-66 | 5.31 | 1.10e-07 | 0.55 | FALSE |
| PL | Pced1a | alternative polyA | XM_006235015.4 | 0.17 | 1479 | 0.23 | 4.0e-25 | -5.24 | 1.59e-07 | 0.45 | FALSE |
| PL | Pced1a | alternative polyA | XM_039104578.2 | 0.63 | 1 | 0.53 | 6.3e-68 | 5.33 | 9.85e-08 | 0.56 | FALSE |
| PL | Fbln7 | gene expression | Fbln7 | 0.27 | 334 | 0.2 | 2.4e-21 | -5.31 | 1.11e-07 | 0.43 | FALSE |
| PL | Ubox5 | gene expression | Ubox5 | 0.14 | 12 | 0.16 | 7.2e-17 | -5.29 | 1.24e-07 | 0.54 | FALSE |
| PL | Pced1a | isoform ratio | XM_039104578.2 | 0.44 | 55 | 0.49 | 2.6e-61 | 5.32 | 1.03e-07 | 0.54 | FALSE |
| PL | Ubox5 | intron excision ratio | chr3_138271085_138272928 | 0.61 | 11 | 0.63 | 3.7e-88 | 5.32 | 1.03e-07 | 0.49 | TRUE |
| PL | Zc3h6 | intron excision ratio | chr3_136709591_136713027 | 0.26 | 9 | 0.1 | 5.6e-11 | 5.45 | 5.15e-08 | 0.42 | FALSE |
| PL | Ebf4 | mRNA stability | Ebf4 | 0.12 | 1683 | 0.16 | 1.2e-16 | 5.27 | 1.35e-07 | 0.44 | FALSE |
| PL | Pced1a | mRNA stability | Pced1a | 0.15 | 8 | 0.16 | 1.1e-16 | -5.52 | 3.40e-08 | 0.54 | FALSE |
| PL | Ubox5 | mRNA stability | Ubox5 | 0.02 | 839 | 0.01 | 1.0e-02 | -5.26 | 1.40e-07 | 0.4 | FALSE |
| pVTA | Pced1a | alternative polyA | XM_006235015.4 | 0.08 | 80 | 0.1 | 3.4e-08 | -5.26 | 1.43e-07 | 0.45 | FALSE |
| pVTA | Pced1a | alternative polyA | XM_039104578.2 | 0.17 | 226 | 0.26 | 1.2e-20 | 5.29 | 1.22e-07 | 0.46 | FALSE |
| pVTA | Zc3h6 | alternative TSS | NM_001107772.1 | 0.06 | 90 | 0.06 | 2.3e-05 | 5.28 | 1.31e-07 | 0.39 | FALSE |
| pVTA | Zc3h6 | alternative TSS | XM_008762235.4 | 0.06 | 2241 | 0.06 | 2.3e-05 | -5.21 | 1.89e-07 | 0.39 | FALSE |
| pVTA | Zc3h8 | alternative TSS | XM_063283754.1 | 0.09 | 55 | 0.08 | 1.1e-06 | 5.37 | 7.99e-08 | 0.4 | FALSE |
| pVTA | Cpxm1 | gene expression | Cpxm1 | 0.06 | 13 | 0.05 | 7.3e-05 | 5.33 | 9.63e-08 | 0.42 | FALSE |
| pVTA | Fbln7 | gene expression | Fbln7 | 0.47 | 54 | 0.46 | 5.7e-41 | -5.49 | 4.04e-08 | 0.49 | FALSE |
| pVTA | Mrps26 | gene expression | Mrps26 | 0.23 | 69 | 0.2 | 6.4e-16 | -5.22 | 1.81e-07 | 0.49 | FALSE |
| pVTA | Pced1a | gene expression | Pced1a | 0.05 | 17 | 0.06 | 1.7e-05 | -5.22 | 1.74e-07 | 0.44 | FALSE |
| pVTA | Ubox5 | intron excision ratio | chr3_138271085_138272928 | 0.72 | 30 | 0.74 | 6.2e-87 | 5.29 | 1.21e-07 | 0.61 | FALSE |
| RMTg | Pced1a | alternative polyA | XM_006235015.4 | 0.15 | 1479 | 0.08 | 3.9e-03 | -5.26 | 1.46e-07 | 0.43 | FALSE |
| RMTg | Ubox5 | gene expression | Ubox5 | 0.2 | 839 | 0.08 | 4.5e-03 | -5.28 | 1.30e-07 | 0.44 | FALSE |