Best TWAS P=3.375581e-08 · Best GWAS P=7.055969e-08 conditioned to 7.565286e-24
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Smoc1 | isoform ratio | ENSRNOT00000101574 | 0.07 | 0.01 | enet | 24 | 0.02 | 1.6e-03 | 4.9 | 5.2 | 1.6e-07 | 0.75 | 0.30 | 0.63 | FALSE |
| 2 | Adipose | Smoc1 | isoform ratio | ENSRNOT00000114143 | 0.06 | 0.01 | enet | 20 | 0.03 | 6.2e-04 | 4.9 | -5.2 | 1.6e-07 | -0.76 | 0.18 | 0.81 | FALSE |
| 3 | BLA | Plekhd1 | gene expression | ENSRNOG00000038297 | 0.20 | 0.10 | blup | 1806 | 0.16 | 8.7e-09 | 4.8 | 5.4 | 7.8e-08 | 0.73 | 0.34 | 0.66 | FALSE |
| 4 | LHb | Galnt16 | gene expression | ENSRNOG00000004589 | 0.30 | 0.16 | enet | 6 | 0.25 | 1.4e-06 | -3.6 | 5.4 | 6.0e-08 | 0.81 | 0.57 | 0.23 | FALSE |
| 5 | Liver | Smoc1 | mRNA stability | ENSRNOG00000005998 | 0.10 | 0.05 | lasso | 25 | 0.07 | 2.3e-08 | -3.9 | -5.5 | 3.4e-08 | -0.55 | 0.96 | 0.04 | TRUE |
| 6 | PL | Slc8a3 | isoform ratio | ENSRNOT00000102013 | 0.06 | 0.04 | top1 | 1 | 0.04 | 1.0e-03 | 5.2 | -5.2 | 2.0e-07 | -0.91 | 0.06 | 0.62 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.