Best TWAS P=4.876508e-12 · Best GWAS P=4.978672e-13 conditioned to 0
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | Unc80 | gene expression | ENSRNOG00000028362 | 0.18 | 0.12 | enet | 162 | 0.13 | 9.5e-15 | -4.39 | -5.5 | 4.9e-08 | 0.61 | 1.00 | 0.00 | TRUE |
2 | Adipose | NA | gene expression | ENSRNOG00000063935 | 0.08 | 0.02 | top1 | 1 | 0.02 | 1.5e-03 | -6.60 | 6.6 | 4.1e-11 | -0.48 | 0.11 | 0.05 | TRUE |
3 | BLA | Lancl1 | gene expression | ENSRNOG00000013557 | 0.39 | 0.35 | top1 | 1 | 0.35 | 2.2e-19 | -5.48 | 5.5 | 4.2e-08 | -0.28 | 1.00 | 0.00 | FALSE |
4 | Brain | Lancl1 | gene expression | ENSRNOG00000013557 | 0.27 | 0.55 | enet | 443 | 0.56 | 4.0e-62 | -5.55 | 5.5 | 4.9e-08 | -0.39 | 1.00 | 0.00 | FALSE |
5 | Brain | NA | gene expression | ENSRNOG00000068276 | 0.08 | 0.06 | blup | 2374 | 0.07 | 8.3e-07 | -5.64 | 5.7 | 9.4e-09 | -0.57 | 0.99 | 0.01 | TRUE |
6 | Brain | Map2 | intron excision ratio | chr9:67952936:67956162 | 0.06 | 0.03 | lasso | 15 | 0.03 | 5.9e-04 | -0.34 | 5.1 | 3.2e-07 | -0.06 | 0.91 | 0.05 | TRUE |
7 | Brain | Lancl1 | mRNA stability | ENSRNOG00000013557 | 0.08 | 0.07 | top1 | 1 | 0.07 | 2.1e-07 | -5.63 | 5.6 | 1.8e-08 | -0.46 | 0.94 | 0.00 | FALSE |
8 | Liver | Acadl | gene expression | ENSRNOG00000012966 | 0.08 | 0.02 | enet | 339 | 0.02 | 9.0e-04 | 1.11 | -6.9 | 4.9e-12 | 0.77 | 0.63 | 0.05 | TRUE |
9 | Liver | Lancl1 | gene expression | ENSRNOG00000013557 | 0.59 | 0.34 | enet | 260 | 0.34 | 5.7e-39 | -5.72 | 5.5 | 2.9e-08 | -0.47 | 1.00 | 0.00 | FALSE |
10 | Liver | Lancl1 | mRNA stability | ENSRNOG00000013557 | 0.04 | 0.01 | top1 | 1 | 0.01 | 1.0e-02 | -5.72 | 5.7 | 1.1e-08 | -0.35 | 0.07 | 0.03 | FALSE |
11 | NAcc | NA | gene expression | ENSRNOG00000065023 | 0.04 | 0.02 | blup | 2473 | 0.03 | 3.8e-03 | -5.61 | -5.1 | 3.4e-07 | 0.28 | 0.51 | 0.41 | FALSE |
12 | NAcc | NA | gene expression | ENSRNOG00000068276 | 0.12 | 0.08 | blup | 2373 | 0.09 | 4.6e-07 | -5.53 | 5.7 | 1.0e-08 | -0.58 | 0.57 | 0.43 | FALSE |
13 | NAcc | Kansl1l | mRNA stability | ENSRNOG00000028149 | 0.04 | 0.04 | top1 | 1 | 0.04 | 6.4e-04 | -5.70 | -5.7 | 1.2e-08 | 0.34 | 0.10 | 0.03 | FALSE |
14 | OFC | Lancl1 | gene expression | ENSRNOG00000013557 | 0.45 | 0.43 | top1 | 1 | 0.43 | 2.2e-11 | -5.69 | 5.7 | 1.3e-08 | -0.29 | 0.90 | 0.01 | FALSE |
15 | OFC | NA | gene expression | ENSRNOG00000068276 | 0.21 | 0.21 | top1 | 1 | 0.21 | 1.3e-05 | -5.64 | 5.6 | 1.7e-08 | -0.36 | 0.14 | 0.05 | FALSE |
16 | PL | Lancl1 | gene expression | ENSRNOG00000013557 | 0.38 | 0.39 | enet | 77 | 0.41 | 4.8e-33 | -5.68 | 5.2 | 2.3e-07 | -0.36 | 0.99 | 0.01 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.