Best TWAS P = 2.84e-09 · Best GWAS P= 4.83e-08 conditioned to 4.80e-72
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Cox16 | gene expression | Cox16 | 0.04 | 1 | 0.04 | 1.9e-05 | -5.32 | 1.06e-07 | 0.93 | TRUE |
| Adipose | LOC120103570 | gene expression | LOC120103570 | 0.1 | 1960 | 0.07 | 2.3e-08 | 5.73 | 9.83e-09 | 0.26 | FALSE |
| Adipose | Smoc1 | isoform ratio | XM_063261933.1 | 0.05 | 62 | 0.02 | 2.1e-03 | 5.94 | 2.84e-09 | 0.35 | TRUE |
| BLA | Plekhd1 | gene expression | Plekhd1 | 0.22 | 2101 | 0.17 | 1.7e-09 | 5.5 | 3.90e-08 | 0.62 | FALSE |
| BLA | LOC120103571 | intron excision ratio | chr6_106635746_106660864 | 0.16 | 17 | 0.1 | 3.6e-06 | -5.6 | 2.09e-08 | 0.21 | FALSE |
| IC | Cox16 | isoform ratio | NM_001163153.1 | 0.18 | 79 | 0.15 | 7.6e-07 | -5.23 | 1.68e-07 | 0.59 | FALSE |
| IL | Galnt16 | gene expression | Galnt16 | 0.33 | 1833 | 0.2 | 1.4e-05 | 5.38 | 7.66e-08 | 0.55 | FALSE |
| IL | LOC134479416 | gene expression | LOC134479416 | 0.2 | 1 | 0.14 | 3.5e-04 | 5.27 | 1.34e-07 | 0.14 | FALSE |
| IL | Srsf5 | isoform ratio | XR_010052053.1 | 0.74 | 34 | 0.22 | 4.2e-06 | -5.29 | 1.20e-07 | 0.26 | FALSE |
| LHb | Srsf5 | alternative TSS | XM_039111859.2 | 0.22 | 2501 | 0.06 | 1.8e-02 | 5.52 | 3.32e-08 | 0.23 | TRUE |
| Liver | Smoc1 | intron excision ratio | chr6_106591719_106592111 | 0.14 | 2028 | 0.08 | 1.8e-09 | 5.48 | 4.27e-08 | 0.75 | FALSE |
| NAcc | Erh | intron excision ratio | chr6_106019923_106022422 | 0.13 | 80 | 0.08 | 3.8e-12 | 5.48 | 4.36e-08 | 0 | FALSE |
| OFC | Galnt16 | alternative TSS | NM_001100863.1 | 0.3 | 1833 | 0.18 | 5.8e-05 | 5.31 | 1.10e-07 | 0.48 | FALSE |
| OFC | Galnt16 | alternative TSS | XM_006240288.5 | 0.29 | 1833 | 0.2 | 2.2e-05 | -5.32 | 1.05e-07 | 0.49 | FALSE |
| OFC | Galnt16 | isoform ratio | NM_001100863.1 | 0.32 | 1833 | 0.15 | 2.3e-04 | 5.49 | 4.11e-08 | 0.47 | FALSE |
| OFC | Galnt16 | isoform ratio | XM_006240288.5 | 0.33 | 1833 | 0.14 | 2.8e-04 | -5.37 | 7.75e-08 | 0.47 | FALSE |
| PL | Dcaf5 | isoform ratio | XM_017594145.3 | 0.04 | 48 | 0.01 | 3.1e-02 | 5.86 | 4.50e-09 | 0.67 | FALSE |
| pVTA | Adam4 | gene expression | Adam4 | 0.08 | 7 | 0.02 | 4.3e-03 | -5.94 | 2.93e-09 | 0.71 | FALSE |
| pVTA | LOC120103560 | gene expression | LOC120103560 | 0.05 | 2486 | 0.03 | 2.1e-03 | -5.35 | 9.04e-08 | 0.47 | FALSE |
| pVTA | LOC134479404 | gene expression | LOC134479404 | 0.06 | 31 | 0.04 | 5.8e-04 | 5.4 | 6.61e-08 | 0.51 | FALSE |
| pVTA | Synj2bp | gene expression | Synj2bp | 0.09 | 115 | 0.04 | 1.5e-04 | -5.77 | 7.90e-09 | 0.46 | FALSE |