Best TWAS P=6.687344e-10 · Best GWAS P=8.05872e-07 conditioned to 0.5933768
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brain | Pnpla8 | gene expression | ENSRNOG00000039091 | 0.11 | 0.07 | lasso | 20 | 0.09 | 6.7e-09 | 4.8 | 5.7 | 1.2e-08 | 0.80 | 0.36 | 0.64 | FALSE |
| 2 | PL | Pnpla8 | gene expression | ENSRNOG00000039091 | 0.19 | 0.09 | blup | 2582 | 0.11 | 7.7e-09 | -4.4 | 6.2 | 6.7e-10 | 0.74 | 0.84 | 0.16 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.