Best TWAS P=4.35243e-09 · Best GWAS P=2.104483e-09 conditioned to 1
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Brain | Nabp1 | gene expression | ENSRNOG00000015416 | 0.04 | 0.03 | top1 | 1 | 0.03 | 1.8e-03 | -5.4 | 5.4 | 5.1e-08 | -0.82 | 0.05 | 0.13 | FALSE |
2 | Brain | Tmeff2 | gene expression | ENSRNOG00000016623 | 0.09 | 0.05 | blup | 2471 | 0.06 | 3.5e-06 | -5.5 | 5.7 | 1.2e-08 | -0.94 | 0.54 | 0.46 | FALSE |
3 | Brain | Tmeff2 | mRNA stability | ENSRNOG00000016623 | 0.48 | 0.10 | lasso | 9 | 0.16 | 7.1e-15 | -5.3 | 5.7 | 9.5e-09 | -0.81 | 0.84 | 0.16 | FALSE |
4 | IL | Tmeff2 | gene expression | ENSRNOG00000016623 | 0.25 | 0.09 | top1 | 1 | 0.09 | 3.8e-03 | -5.4 | 5.4 | 7.7e-08 | -0.94 | 0.12 | 0.05 | FALSE |
5 | Liver | Tmeff2 | alternative TSS | ENSRNOT00000081677 | 0.02 | 0.01 | blup | 2471 | 0.01 | 2.4e-02 | -4.8 | -5.9 | 4.4e-09 | 0.97 | 0.46 | 0.26 | TRUE |
6 | Liver | Tmeff2 | alternative TSS | ENSRNOT00000081677 | 0.02 | 0.01 | blup | 2471 | 0.01 | 3.2e-02 | -4.8 | -5.9 | 4.5e-09 | 0.97 | 0.42 | 0.23 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.