Best TWAS P = 4.87e-08 · Best GWAS P= 1.95e-08 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Vipr2 | gene expression | Vipr2 | 0.03 | 2 | 0.03 | 4.2e-04 | 5.46 | 4.87e-08 | 0.51 | TRUE |
| BLA | Ncapg2 | isoform ratio | XM_343124.10 | 0.09 | 19 | 0.04 | 2.0e-03 | -5.28 | 1.30e-07 | 0.45 | FALSE |
| BLA | Ncapg2 | intron excision ratio | chr6_143486482_143488159 | 0.07 | 1 | 0.04 | 3.7e-03 | -5.4 | 6.54e-08 | 0.4 | FALSE |
| Brain | Esyt2 | alternative polyA | XM_039112119.2 | 0.08 | 5 | 0.08 | 1.2e-07 | -5.37 | 8.04e-08 | 0.54 | FALSE |
| Brain | Esyt2 | gene expression | Esyt2 | 0.87 | 41 | 0.66 | 1.2e-81 | -5.21 | 1.86e-07 | 0.46 | FALSE |
| Brain | Esyt2 | isoform ratio | NM_001271169.1 | 0.03 | 3 | 0.02 | 1.1e-02 | 5.35 | 8.70e-08 | 0.41 | FALSE |
| Brain | Ncapg2 | intron excision ratio | chr6_143486482_143488159 | 0.12 | 1 | 0.12 | 2.1e-11 | -5.22 | 1.83e-07 | 0.64 | FALSE |
| IC | Ptprn2 | alternative polyA | NM_031600.2 | 0.09 | 368 | 0.1 | 7.6e-05 | -5.37 | 8.08e-08 | 0.43 | FALSE |
| IC | Ptprn2 | alternative polyA | NM_031600.2 | 0.09 | 200 | 0.1 | 4.0e-05 | -5.29 | 1.22e-07 | 0.39 | FALSE |
| IC | Ptprn2 | alternative polyA | XM_039111861.2 | 0.07 | 180 | 0.08 | 2.1e-04 | 5.26 | 1.45e-07 | 0.35 | FALSE |
| LHb | Esyt2 | intron excision ratio | chr6_143432854_143441351 | 0.16 | 31 | 0.05 | 3.0e-02 | 5.21 | 1.91e-07 | 0.37 | FALSE |
| NAcc | Esyt2 | intron excision ratio | chr6_143432854_143438056 | 0.02 | 1 | 0.02 | 1.1e-04 | -5.24 | 1.61e-07 | 0.55 | FALSE |
| NAcc | Esyt2 | intron excision ratio | chr6_143450488_143451296 | 0.02 | 1 | 0.03 | 7.2e-06 | -5.24 | 1.61e-07 | 0.42 | FALSE |
| NAcc | Esyt2 | intron excision ratio | chr6_143451401_143452570 | 0.02 | 1 | 0.04 | 2.2e-06 | 5.24 | 1.61e-07 | 0.54 | FALSE |
| NAcc | Esyt2 | mRNA stability | Esyt2 | 0.05 | 1 | 0.04 | 6.4e-07 | 5.22 | 1.80e-07 | 0.62 | FALSE |
| OFC | Esyt2 | mRNA stability | Esyt2 | 0.21 | 1 | 0.15 | 2.2e-04 | 5.45 | 5.00e-08 | 0.1 | FALSE |
| PL | Esyt2 | alternative polyA | XM_039112112.2 | 0.03 | 9 | 0.03 | 1.2e-04 | 5.27 | 1.33e-07 | 0.48 | FALSE |
| PL | Esyt2 | alternative polyA | XM_039112119.2 | 0.03 | 8 | 0.02 | 1.5e-03 | -5.23 | 1.67e-07 | 0.45 | FALSE |
| PL | Esyt2 | gene expression | Esyt2 | 0.75 | 81 | 0.63 | 9.8e-89 | -5.23 | 1.74e-07 | 0.47 | FALSE |
| PL | Esyt2 | isoform ratio | NM_001271169.1 | 0.03 | 1 | 0.04 | 4.4e-05 | 5.24 | 1.61e-07 | 0.34 | FALSE |
| PL | Esyt2 | intron excision ratio | chr6_143432854_143441351 | 0.03 | 56 | 0.02 | 1.4e-03 | 5.37 | 7.92e-08 | 0.47 | FALSE |
| PL | Esyt2 | mRNA stability | Esyt2 | 0.12 | 11 | 0.15 | 4.5e-16 | 5.22 | 1.78e-07 | 0.48 | FALSE |