chr1:149,923,636-152,140,050

Trait: Total locomotion distance, hab. session 1

Best TWAS P = 5.65e-13 · Best GWAS P= 2.38e-13 conditioned to 1.00e+00

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h²	# weights	Model R²	Model R² P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Ctsc	isoform ratio	NM_017097.2	0.17	2571	0.16	1.9e-17	5.43	5.59e-08	0	FALSE
Adipose	Ctsc	isoform ratio	XM_008759637.4	0.17	2571	0.17	3.0e-18	-5.4	6.83e-08	0	FALSE
Adipose	Ctsc	intron excision ratio	chr1_151443766_151448822	0.05	2571	0.03	7.1e-04	-6.08	1.18e-09	0.62	FALSE
Adipose	Ctsc	intron excision ratio	chr1_151443766_151458158	0.04	2571	0.03	4.0e-04	5.83	5.49e-09	0.56	FALSE
BLA	Ctsc	isoform ratio	NM_017097.2	0.06	1	0.03	1.8e-02	-6.11	1.01e-09	0.04	FALSE
BLA	Ctsc	isoform ratio	XM_008759637.4	0.06	1	0.02	1.8e-02	6.11	1.01e-09	0.04	FALSE
Brain	Ctsc	alternative polyA	NM_017097.2	0.06	24	0.07	6.8e-07	-6.55	5.79e-11	0.63	FALSE
Brain	Ctsc	alternative polyA	XM_008759637.4	0.06	24	0.07	7.0e-07	6.56	5.36e-11	0.62	FALSE
Brain	Grm5	gene expression	Grm5	0.46	13	0.3	2.7e-28	6.83	8.36e-12	0.61	FALSE
Brain	Ctsc	isoform ratio	NM_017097.2	0.06	1	0.05	2.1e-05	-6.61	3.97e-11	0.21	FALSE
Brain	Ctsc	isoform ratio	XM_008759637.4	0.06	1	0.05	2.6e-05	6.61	3.97e-11	0.2	FALSE
Brain	Grm5	mRNA stability	Grm5	0.1	1	0.09	4.9e-09	-6.59	4.26e-11	0.08	FALSE
Eye	Ctsc	gene expression	Ctsc	0.34	13	0.16	1.8e-03	-6.07	1.28e-09	0.21	FALSE
IC	Ctsc	alternative polyA	NM_017097.2	0.09	1	0.06	1.6e-03	-5.72	1.08e-08	0.04	FALSE
IC	Ctsc	alternative polyA	XM_008759637.4	0.08	1	0.05	2.6e-03	5.72	1.08e-08	0.04	TRUE
IC	Grm5	gene expression	Grm5	0.3	44	0.24	1.4e-10	6.21	5.18e-10	0.2	FALSE
IC	Grm5	isoform ratio	XM_006229659.5	0.06	52	0.03	2.4e-02	6.36	2.04e-10	0.27	FALSE
IL	Ctsc	gene expression	Ctsc	0.44	18	0.11	1.6e-03	-7.21	5.65e-13	0.64	TRUE
LHb	Ctsc	gene expression	Ctsc	0.2	15	0.14	3.9e-04	-5.98	2.19e-09	0.14	TRUE
Liver	LOC102554680	gene expression	LOC102554680	0.05	13	0.04	7.2e-05	6.5	8.07e-11	0.64	FALSE
NAcc	Ctsc	alternative polyA	NM_017097.2	0.04	1	0.04	2.0e-06	-5.97	2.39e-09	0.01	FALSE
NAcc	Ctsc	alternative polyA	XM_008759637.4	0.04	27	0.04	1.0e-06	6.3	2.94e-10	0.32	FALSE
NAcc	Ctsc	gene expression	Ctsc	0.13	2571	0.19	2.3e-28	-6.01	1.87e-09	0.49	FALSE
NAcc	Grm5	gene expression	Grm5	0.08	1	0.08	7.3e-12	-6.82	9.30e-12	0.26	FALSE
NAcc	Tyr	gene expression	Tyr	0.02	2904	0.01	1.3e-02	6.22	5.00e-10	0.43	TRUE
NAcc	Ctsc	isoform ratio	NM_017097.2	0.05	1	0.05	2.9e-08	-5.97	2.39e-09	0.01	FALSE
NAcc	Ctsc	isoform ratio	XM_008759637.4	0.05	1	0.05	1.5e-07	5.97	2.39e-09	0.01	FALSE
NAcc	Ctsc	intron excision ratio	chr1_151443766_151448822	0.02	1	0.01	1.7e-03	5.97	2.39e-09	0.02	FALSE
NAcc	Ctsc	intron excision ratio	chr1_151443766_151458158	0.02	4	0.01	8.6e-03	-6.22	5.11e-10	0.52	FALSE
NAcc	Grm5	mRNA stability	Grm5	0.03	1	0.03	3.3e-05	-6.82	9.30e-12	0.11	FALSE
OFC	Grm5	gene expression	Grm5	0.23	11	0.16	1.0e-04	-6.87	6.23e-12	0.44	TRUE
PL	Ctsc	alternative polyA	NM_017097.2	0.03	2571	0.02	1.7e-03	5.26	1.43e-07	0.23	FALSE
PL	Ctsc	gene expression	Ctsc	0.21	2571	0.21	1.0e-22	-5.53	3.21e-08	0.15	FALSE
PL	Grm5	gene expression	Grm5	0.03	2746	0.02	2.8e-03	6.1	1.06e-09	0.35	FALSE
PL	Ctsc	isoform ratio	NM_017097.2	0.02	2571	0.02	2.0e-03	5.23	1.67e-07	0.2	FALSE
PL	Ctsc	isoform ratio	XM_008759637.4	0.02	2571	0.02	2.0e-03	-5.22	1.78e-07	0.2	TRUE
PL	Grm5	intron excision ratio	chr1_150723078_150733678	0.03	2746	0.02	1.7e-03	5.66	1.50e-08	0.14	TRUE