Hub : Traits : Total locomotion distance, hab. session 1 : ← →

chr1:140,614,300-142,727,457

Trait: Total locomotion distance, hab. session 1

Best TWAS P=2.880031e-13 · Best GWAS P=2.805437e-13 conditioned to 3.918398e-215

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Ctsc	alternative polyA	ENSRNOT00000022342	0.16	0.14	blup	2515	0.17	2.8e-18	4.1	5.5	4.8e-08	-0.85	1.00	0.00	FALSE
2	Adipose	Ctsc	alternative polyA	ENSRNOT00000097085	0.17	0.13	blup	2515	0.19	1.5e-20	3.9	-5.6	1.9e-08	0.87	0.97	0.03	FALSE
3	Adipose	Ctsc	isoform ratio	ENSRNOT00000022342	0.16	0.10	blup	2515	0.16	4.3e-17	4.1	5.7	1.1e-08	-0.88	0.81	0.19	FALSE
4	Adipose	Ctsc	isoform ratio	ENSRNOT00000097085	0.18	0.11	blup	2515	0.18	1.3e-19	-6.5	-5.8	4.9e-09	0.89	0.60	0.40	FALSE
5	Adipose	Ctsc	intron excision ratio	chr1:142031177:142036233	0.05	0.03	blup	2515	0.04	6.5e-05	-6.8	-6.0	1.7e-09	0.91	0.40	0.60	FALSE
6	Adipose	Ctsc	intron excision ratio	chr1:142031177:142045569	0.04	0.01	blup	2515	0.02	4.7e-03	-6.8	5.7	9.3e-09	-0.88	0.48	0.49	FALSE
7	BLA	Ctsc	alternative polyA	ENSRNOT00000022342	0.07	0.00	blup	2518	0.01	5.1e-02	-5.3	5.5	3.5e-08	-0.73	0.46	0.20	FALSE
8	BLA	Ctsc	alternative polyA	ENSRNOT00000097085	0.07	0.00	blup	2518	0.02	3.2e-02	2.5	-5.3	1.2e-07	0.70	0.46	0.17	FALSE
9	BLA	Ctsc	gene expression	ENSRNOG00000016496	0.12	0.10	top1	1	0.10	5.0e-06	-5.9	-5.9	3.7e-09	0.95	0.34	0.03	FALSE
10	BLA	Ctsc	mRNA stability	ENSRNOG00000016496	0.05	0.03	top1	1	0.03	1.5e-02	-7.2	7.2	7.5e-13	-0.90	0.09	0.10	FALSE
11	Brain	Grm5	gene expression	ENSRNOG00000016429	0.16	0.10	lasso	6	0.15	5.3e-14	-6.6	6.2	4.5e-10	-0.86	0.36	0.64	FALSE
12	Brain	Ctsc	gene expression	ENSRNOG00000016496	0.23	0.27	blup	2518	0.31	4.5e-29	3.9	-5.3	1.1e-07	0.84	1.00	0.00	FALSE
13	Brain	Ctsc	isoform ratio	ENSRNOT00000022342	0.03	0.04	top1	1	0.04	1.7e-04	-7.3	7.3	2.9e-13	-0.90	0.04	0.70	TRUE
14	Eye	Ctsc	gene expression	ENSRNOG00000016496	0.29	0.15	top1	1	0.15	2.9e-03	-6.5	-6.5	8.4e-11	0.93	0.14	0.06	FALSE
15	IL	Ctsc	gene expression	ENSRNOG00000016496	0.30	0.16	top1	1	0.16	1.0e-04	-6.7	-6.7	2.8e-11	0.92	0.13	0.06	FALSE
16	NAcc	Ctsc	gene expression	ENSRNOG00000016496	0.12	0.09	blup	2516	0.12	3.3e-09	-6.5	-6.2	7.4e-10	0.93	0.54	0.46	FALSE
17	PL	Ctsc	gene expression	ENSRNOG00000016496	0.14	0.11	enet	87	0.13	8.2e-10	-6.7	-5.6	1.9e-08	0.76	0.34	0.66	FALSE
18	PL	Grm5	mRNA stability	ENSRNOG00000016429	0.04	0.03	top1	1	0.03	1.3e-03	-7.2	-7.2	6.7e-13	0.92	0.09	0.06	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.