Best TWAS P = 3.35e-13 · Best GWAS P= 5.10e-13 conditioned to 6.68e-01
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | LOC120096594 | gene expression | LOC120096594 | 0.11 | 18 | 0.13 | 1.2e-14 | -5.66 | 1.47e-08 | 0.86 | FALSE |
| Brain | Aasdh | isoform ratio | XM_063273418.1 | 0.15 | 14 | 0.11 | 1.5e-10 | -5.37 | 7.96e-08 | 0.32 | FALSE |
| Brain | Exoc1 | mRNA stability | Exoc1 | 0.08 | 2169 | 0.03 | 1.1e-03 | -5.91 | 3.32e-09 | 0.28 | FALSE |
| Brain | Pdcl2 | mRNA stability | Pdcl2 | 0.08 | 1 | 0.05 | 1.8e-05 | -6.26 | 3.73e-10 | 0.08 | TRUE |
| IC | Pdcl2 | gene expression | Pdcl2 | 0.11 | 1 | 0.05 | 4.0e-03 | 7.28 | 3.35e-13 | 0.58 | TRUE |
| NAcc | LOC134481741 | gene expression | LOC134481741 | 0.03 | 21 | 0.04 | 9.3e-07 | 5.21 | 1.85e-07 | 0.38 | FALSE |
| NAcc | Exoc1 | mRNA stability | Exoc1 | 0.03 | 1 | 0.02 | 1.1e-04 | 6.26 | 3.73e-10 | 0.03 | FALSE |
| PL | Exoc1 | mRNA stability | Exoc1 | 0.03 | 2169 | 0.01 | 9.8e-03 | -5.62 | 1.88e-08 | 0.05 | FALSE |
| pVTA | Pdcl2 | intron excision ratio | chr14_32241901_32243057 | 0.06 | 14 | 0.02 | 7.7e-03 | 5.65 | 1.62e-08 | 0.63 | TRUE |