Best TWAS P=7.524336e-11 · Best GWAS P=3.395345e-14 conditioned to 0.003011261
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Kit | mRNA stability | ENSRNOG00000002227 | 0.03 | 0.03 | enet | 416 | 0.05 | 4.0e-06 | -6.9 | -6.5 | 7.5e-11 | 0.90 | 0.06 | 0.92 | TRUE |
| 2 | Brain | Exoc1 | mRNA stability | ENSRNOG00000002144 | 0.08 | 0.01 | enet | 16 | 0.05 | 1.8e-05 | 4.2 | -6.5 | 1.0e-10 | 0.60 | 0.47 | 0.43 | TRUE |
| 3 | IL | Lnx1 | gene expression | ENSRNOG00000002272 | 0.64 | 0.20 | lasso | 9 | 0.24 | 1.7e-06 | -4.8 | -5.1 | 2.9e-07 | 0.54 | 0.38 | 0.60 | FALSE |
| 4 | Liver | Cracd | gene expression | ENSRNOG00000002139 | 0.08 | 0.08 | enet | 53 | 0.08 | 5.5e-09 | 3.8 | 5.5 | 4.4e-08 | -0.54 | 1.00 | 0.00 | FALSE |
| 5 | NAcc | Exoc1 | isoform ratio | ENSRNOT00000090470 | 0.23 | 0.11 | blup | 2104 | 0.12 | 3.9e-09 | 4.2 | 5.1 | 3.5e-07 | -0.44 | 1.00 | 0.00 | FALSE |
| 6 | PL | Lnx1 | gene expression | ENSRNOG00000002272 | 0.36 | 0.27 | blup | 2308 | 0.31 | 1.1e-23 | -4.6 | -5.2 | 2.5e-07 | 0.55 | 0.38 | 0.62 | FALSE |
| 7 | PL | Exoc1 | mRNA stability | ENSRNOG00000002144 | 0.06 | 0.03 | blup | 2104 | 0.04 | 4.5e-04 | 4.2 | -5.8 | 6.4e-09 | 0.65 | 0.46 | 0.18 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.