Best TWAS P=7.984108e-08 · Best GWAS P=1.630892e-06 conditioned to 0.4385941
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | BLA | Ctsc | alternative polyA | ENSRNOT00000022342 | 0.07 | 0.0 | blup | 2518 | 0.01 | 5.1e-02 | 4.0 | -5.4 | 8.0e-08 | 0.81 | 0.42 | 0.26 | TRUE |
2 | BLA | Ctsc | alternative polyA | ENSRNOT00000097085 | 0.07 | 0.0 | blup | 2518 | 0.02 | 3.2e-02 | -4.5 | 5.4 | 8.2e-08 | -0.84 | 0.40 | 0.27 | FALSE |
3 | Brain | Grm5 | gene expression | ENSRNOG00000016429 | 0.16 | 0.1 | lasso | 6 | 0.15 | 5.3e-14 | 4.2 | -5.2 | 2.0e-07 | 0.73 | 0.66 | 0.34 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.