Hub : Traits : Parametrial fat weight : ← →

chr1:257,808,644-260,518,987

Trait: Parametrial fat weight

Best TWAS P=1.382869e-18 · Best GWAS P=2.761092e-19 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Dennd10	gene expression	ENSRNOG00000010230	0.03	0.03	top1	1	0.03	2.5e-04	-7.1	-7.1	1.2e-12	0.69	0.24	0.02	FALSE
2	Adipose	Prdx3	gene expression	ENSRNOG00000010958	0.19	0.22	lasso	34	0.22	1.6e-23	-5.2	-5.4	7.0e-08	0.53	1.00	0.00	FALSE
3	Adipose	Grk5	gene expression	ENSRNOG00000011439	0.17	0.20	lasso	24	0.22	8.6e-24	-7.2	7.0	2.1e-12	-0.73	1.00	0.00	FALSE
4	Adipose	Ces2c	gene expression	ENSRNOG00000036571	0.11	0.03	blup	596	0.07	2.3e-08	-3.7	5.2	1.7e-07	-0.56	0.83	0.17	FALSE
5	Adipose	Pdzd8	mRNA stability	ENSRNOG00000009460	0.04	0.00	blup	1998	0.01	7.6e-02	-7.8	6.0	2.5e-09	-0.50	0.42	0.05	FALSE
6	Adipose	Fam204a	mRNA stability	ENSRNOG00000009830	0.03	0.01	enet	64	0.01	5.4e-02	-4.3	5.4	8.7e-08	-0.51	0.46	0.06	TRUE
7	Adipose	Cacul1	mRNA stability	ENSRNOG00000009954	0.09	0.03	enet	62	0.04	5.6e-05	-2.0	5.4	7.7e-08	-0.74	0.96	0.03	FALSE
8	BLA	Rab11fip2	gene expression	ENSRNOG00000009523	0.11	0.05	top1	1	0.05	1.1e-03	-5.4	-5.4	7.9e-08	0.71	0.12	0.04	FALSE
9	BLA	Ces2c	gene expression	ENSRNOG00000036571	0.26	0.19	lasso	16	0.20	1.1e-10	-7.1	7.1	1.3e-12	-0.71	0.33	0.67	FALSE
10	BLA	Sfxn4	gene expression	ENSRNOG00000036572	0.07	0.02	top1	1	0.02	2.1e-02	-8.3	8.3	8.2e-17	-0.83	0.06	0.04	FALSE
11	BLA	Cacul1	isoform ratio	ENSRNOT00000084760	0.07	0.00	top1	1	0.00	2.4e-01	-7.2	-7.2	5.4e-13	0.69	0.07	0.04	FALSE
12	Brain	Rab11fip2	gene expression	ENSRNOG00000009523	0.09	0.05	lasso	2	0.06	3.6e-06	-5.8	-5.3	1.0e-07	-0.46	0.96	0.04	FALSE
13	Brain	Prlhr	gene expression	ENSRNOG00000009922	0.03	0.01	blup	1906	0.01	1.4e-02	-4.4	6.6	4.5e-11	-0.77	0.45	0.23	FALSE
14	Brain	Cacul1	gene expression	ENSRNOG00000009954	0.16	0.15	blup	1783	0.15	4.8e-14	-4.5	5.4	6.2e-08	-0.69	1.00	0.00	FALSE
15	Brain	Nanos1	gene expression	ENSRNOG00000025060	0.03	0.01	enet	58	0.01	2.2e-02	-7.0	-7.8	4.6e-15	0.86	0.54	0.30	FALSE
16	Brain	Ces2c	gene expression	ENSRNOG00000036571	0.20	0.28	blup	597	0.29	3.4e-27	-7.0	7.0	2.9e-12	-0.70	0.32	0.68	FALSE
17	Brain	Sfxn4	gene expression	ENSRNOG00000036572	0.09	0.08	lasso	36	0.09	2.2e-08	-4.1	6.0	2.5e-09	-0.57	1.00	0.00	TRUE
18	Brain	Cacul1	isoform ratio	ENSRNOT00000050617	0.14	0.11	top1	1	0.11	3.3e-10	-8.8	8.8	1.4e-18	-0.95	0.11	0.89	TRUE
19	Brain	Cacul1	isoform ratio	ENSRNOT00000084760	0.12	0.10	enet	5	0.11	5.6e-10	-8.8	-7.8	5.0e-15	-0.47	0.11	0.89	TRUE
20	Brain	Zfp950	isoform ratio	ENSRNOT00000047883	0.04	0.03	blup	954	0.05	9.3e-06	-7.2	6.4	2.0e-10	-0.62	0.98	0.02	FALSE
21	Brain	Cacul1	intron excision ratio	chr1:259677583:259686255	0.12	0.08	enet	36	0.10	1.6e-09	-8.3	8.0	8.4e-16	-0.25	0.14	0.86	TRUE
22	Eye	NA	gene expression	ENSRNOG00000065260	0.45	0.18	top1	1	0.18	9.5e-04	-8.0	-8.0	1.3e-15	0.91	0.10	0.06	FALSE
23	IL	Ces2c	gene expression	ENSRNOG00000036571	0.35	0.35	top1	1	0.35	2.3e-09	-7.1	7.1	1.2e-12	-0.72	0.24	0.52	FALSE
24	IL	Sfxn4	gene expression	ENSRNOG00000036572	0.19	0.13	top1	1	0.13	5.3e-04	-7.1	7.1	1.6e-12	-0.79	0.08	0.05	FALSE
25	LHb	Ces2c	gene expression	ENSRNOG00000036571	0.25	0.12	blup	594	0.19	2.3e-05	-7.1	6.6	4.1e-11	-0.66	0.34	0.60	FALSE
26	Liver	Rab11fip2	gene expression	ENSRNOG00000009523	0.03	0.00	blup	2371	0.01	1.3e-02	-2.7	-6.2	4.9e-10	0.80	0.39	0.25	FALSE
27	Liver	Nanos1	gene expression	ENSRNOG00000025060	0.03	0.02	top1	1	0.02	1.2e-03	-5.2	-5.2	1.7e-07	0.70	0.07	0.03	TRUE
28	Liver	Zfp950	gene expression	ENSRNOG00000032668	0.03	0.01	top1	1	0.01	7.7e-03	-7.9	-7.9	1.9e-15	0.75	0.03	0.04	FALSE
29	Liver	Cacul1	isoform ratio	ENSRNOT00000050617	0.03	0.02	top1	1	0.02	1.3e-03	-8.2	8.2	1.9e-16	-0.94	0.07	0.03	FALSE
30	Liver	Cacul1	isoform ratio	ENSRNOT00000084760	0.03	0.01	blup	1780	0.02	4.5e-03	-8.4	-7.8	5.0e-15	0.83	0.30	0.44	FALSE
31	Liver	Cacul1	mRNA stability	ENSRNOG00000009954	0.03	0.01	top1	1	0.01	1.4e-02	-8.5	8.5	2.0e-17	-0.94	0.05	0.03	FALSE
32	NAcc	Prlhr	gene expression	ENSRNOG00000009922	0.14	0.09	blup	1904	0.11	2.3e-08	-8.5	8.2	3.6e-16	-0.94	0.18	0.82	FALSE
33	NAcc	Zfp950	gene expression	ENSRNOG00000032668	0.05	0.01	lasso	15	0.02	7.3e-03	-5.6	6.5	6.0e-11	-0.79	0.35	0.37	FALSE
34	NAcc	Ces2c	gene expression	ENSRNOG00000036571	0.22	0.17	blup	597	0.22	5.3e-16	-7.1	6.5	7.9e-11	-0.65	0.36	0.64	FALSE
35	NAcc	Sfxn4	gene expression	ENSRNOG00000036572	0.07	0.04	top1	1	0.04	3.8e-04	-7.8	7.8	7.2e-15	-0.86	0.06	0.03	FALSE
36	NAcc	Cacul1	isoform ratio	ENSRNOT00000050617	0.05	0.05	blup	1781	0.05	9.6e-05	-8.3	8.5	1.4e-17	-0.94	0.34	0.61	FALSE
37	NAcc	Cacul1	isoform ratio	ENSRNOT00000084760	0.05	0.05	blup	1781	0.05	1.6e-04	-8.3	-8.5	1.3e-17	0.94	0.34	0.61	FALSE
38	OFC	Rab11fip2	gene expression	ENSRNOG00000009523	0.30	0.23	lasso	17	0.27	5.1e-07	-8.5	-8.5	2.7e-17	0.98	0.44	0.56	FALSE
39	OFC	Cacul1	gene expression	ENSRNOG00000009954	0.45	0.24	blup	1782	0.41	9.5e-11	-5.1	6.9	5.6e-12	-0.80	0.41	0.59	FALSE
40	OFC	Ces2c	gene expression	ENSRNOG00000036571	0.38	0.42	top1	1	0.42	3.6e-11	-7.1	7.1	1.2e-12	-0.71	0.30	0.67	FALSE
41	OFC	Sfxn4	gene expression	ENSRNOG00000036572	0.41	0.18	enet	17	0.26	7.0e-07	-7.0	7.7	1.4e-14	-0.81	0.96	0.02	FALSE
42	OFC	Rab11fip2	mRNA stability	ENSRNOG00000009523	0.16	0.19	top1	1	0.19	2.9e-05	-8.5	-8.5	2.8e-17	0.89	0.12	0.05	FALSE
43	PL	Rab11fip2	gene expression	ENSRNOG00000009523	0.06	0.04	enet	76	0.05	1.5e-04	-8.3	-8.3	7.1e-17	0.91	0.35	0.64	FALSE
44	PL	Cacul1	gene expression	ENSRNOG00000009954	0.24	0.16	enet	45	0.18	2.4e-13	-4.5	5.7	1.1e-08	-0.77	1.00	0.00	FALSE
45	PL	Ces2c	gene expression	ENSRNOG00000036571	0.39	0.38	top1	1	0.38	3.4e-30	-7.1	7.1	9.9e-13	-0.71	0.27	0.73	FALSE
46	PL	Sfxn4	gene expression	ENSRNOG00000036572	0.17	0.05	enet	158	0.10	9.5e-08	-7.1	7.0	2.7e-12	-0.68	0.94	0.06	FALSE
47	PL	NA	gene expression	ENSRNOG00000065957	0.12	0.07	top1	1	0.07	9.6e-06	5.3	-5.3	1.0e-07	0.59	0.49	0.02	FALSE
48	PL	NA	gene expression	ENSRNOG00000068145	0.06	0.03	lasso	13	0.04	6.9e-04	5.4	-6.5	5.9e-11	0.76	0.45	0.41	FALSE
49	PL	Cacul1	isoform ratio	ENSRNOT00000050617	0.03	0.02	top1	1	0.02	1.8e-02	-8.3	8.3	1.1e-16	-0.90	0.06	0.03	FALSE
50	PL	Zfp950	intron excision ratio	chr1:260237329:260247276	0.03	0.01	blup	954	0.02	1.2e-02	-8.3	7.4	1.0e-13	-0.78	0.22	0.53	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.