Best TWAS P=5.51e-19 · Best GWAS P=2.76e-19 conditioned to NaN
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Grk5 | alternative polyA | XM_039088801.1 | 0.1 | 68 | 0.13 | 8.2e-14 | 7.38 | 1.59e-13 | 0 | FALSE |
| Adipose | Grk5 | alternative polyA | XM_039088820.1 | 0.07 | 1 | 0.09 | 1.5e-10 | -7.05 | 1.83e-12 | 0 | FALSE |
| Adipose | Grk5 | alternative polyA | XM_039088801.1 | 0.11 | 1 | 0.13 | 1.5e-14 | 7.18 | 6.82e-13 | 0 | FALSE |
| Adipose | Grk5 | alternative polyA | XM_039088820.1 | 0.07 | 1 | 0.09 | 3.3e-10 | -7.05 | 1.83e-12 | 0 | FALSE |
| Adipose | Ces2c | gene expression | Ces2c | 0.11 | 55 | 0.07 | 2.4e-08 | -5.91 | 3.50e-09 | 0.34 | TRUE |
| Adipose | Dennd10 | gene expression | Dennd10 | 0.03 | 5 | 0.04 | 8.4e-05 | -7.11 | 1.16e-12 | 0.01 | FALSE |
| Adipose | Grk5 | gene expression | Grk5 | 0.2 | 143 | 0.24 | 5.3e-26 | -6.43 | 1.31e-10 | 0 | FALSE |
| Adipose | LOC102550729 | gene expression | LOC102550729 | 0.04 | 866 | 0.04 | 4.1e-05 | 5.94 | 2.82e-09 | 0.04 | FALSE |
| Adipose | Prdx3 | gene expression | Prdx3 | 0.18 | 1 | 0.23 | 1.2e-24 | 5.22 | 1.74e-07 | 0 | FALSE |
| Adipose | Sfxn4 | gene expression | Sfxn4 | 0.03 | 1 | 0.03 | 2.0e-04 | 7.37 | 1.72e-13 | 0.03 | FALSE |
| Adipose | Zfp950 | gene expression | Zfp950 | 0.03 | 1 | 0.03 | 6.1e-04 | -5.43 | 5.50e-08 | 0.03 | FALSE |
| Adipose | Grk5 | isoform ratio | XM_039088828.1 | 0.03 | 1 | 0.01 | 1.3e-02 | 7.05 | 1.83e-12 | 0.03 | FALSE |
| Adipose | Fam204a | mRNA stability | Fam204a | 0.05 | 112 | 0.02 | 2.5e-03 | -5.38 | 7.56e-08 | 0.04 | FALSE |
| BLA | Grk5 | alternative polyA | XM_039088801.1 | 0.06 | 1 | 0.03 | 1.2e-02 | 8.9 | 5.51e-19 | 0.07 | TRUE |
| BLA | Ces2c | gene expression | Ces2c | 0.24 | 1 | 0.16 | 8.0e-09 | -7.04 | 1.94e-12 | 0.7 | FALSE |
| BLA | Rab11fip2 | gene expression | Rab11fip2 | 0.07 | 1 | 0.04 | 2.4e-03 | 5.37 | 7.90e-08 | 0.04 | FALSE |
| BLA | Sfxn4 | gene expression | Sfxn4 | 0.08 | 1 | 0.04 | 3.6e-03 | -8.17 | 3.06e-16 | 0.04 | FALSE |
| BLA | Emx2os | mRNA stability | Emx2os | 0.13 | 2224 | 0.04 | 3.8e-03 | -7.23 | 4.83e-13 | 0.21 | FALSE |
| BLA | Grk5 | mRNA stability | Grk5 | 0.05 | 1 | 0.01 | 1.3e-01 | 7.04 | 1.99e-12 | 0.04 | FALSE |
| BLA | Rab11fip2 | mRNA stability | Rab11fip2 | 0.07 | 3 | 0.03 | 8.0e-03 | -7.97 | 1.63e-15 | 0.42 | TRUE |
| Brain | Fam204a | alternative polyA | XM_039110388.1 | 0.03 | 1 | 0.04 | 2.4e-04 | 7.1 | 1.27e-12 | 0.03 | FALSE |
| Brain | Grk5 | alternative polyA | XM_039088801.1 | 0.02 | 1 | 0.03 | 6.0e-04 | 7.05 | 1.83e-12 | 0.03 | FALSE |
| Brain | Grk5 | alternative polyA | XM_039088820.1 | 0.03 | 1 | 0.04 | 1.1e-04 | -6.99 | 2.70e-12 | 0.03 | FALSE |
| Brain | Grk5 | alternative polyA | XM_039088801.1 | 0.02 | 1 | 0.03 | 8.1e-04 | 7.05 | 1.83e-12 | 0.03 | FALSE |
| Brain | Grk5 | alternative polyA | XM_039088820.1 | 0.03 | 1 | 0.04 | 1.1e-04 | -6.99 | 2.70e-12 | 0.03 | FALSE |
| Brain | Cacul1 | alternative TSS | NM_001014248.2 | 0.03 | 1786 | 0.03 | 8.3e-04 | -5.71 | 1.11e-08 | 0.11 | FALSE |
| Brain | Cacul1 | alternative TSS | XM_039085812.1 | 0.03 | 1786 | 0.03 | 1.0e-03 | 5.73 | 1.01e-08 | 0.12 | FALSE |
| Brain | Ces2c | gene expression | Ces2c | 0.23 | 1 | 0.27 | 3.5e-25 | -7.1 | 1.21e-12 | 0.79 | FALSE |
| Brain | Hspa12a | gene expression | Hspa12a | 0.11 | 29 | 0.1 | 1.2e-09 | 6 | 1.97e-09 | 0 | FALSE |
| Brain | LOC102550729 | gene expression | LOC102550729 | 0.05 | 1 | 0.06 | 4.1e-06 | -7 | 2.48e-12 | 0.03 | FALSE |
| Brain | Nanos1 | gene expression | Nanos1 | 0.1 | 16 | 0.08 | 3.2e-08 | -7.14 | 9.38e-13 | 0.31 | FALSE |
| Brain | Prlhr | gene expression | Prlhr | 0.03 | 1911 | 0.01 | 1.4e-02 | 7.11 | 1.13e-12 | 0.3 | FALSE |
| Brain | Rab11fip2 | gene expression | Rab11fip2 | 0.1 | 16 | 0.06 | 1.2e-06 | 6.05 | 1.43e-09 | 0.22 | FALSE |
| Brain | Sfxn4 | gene expression | Sfxn4 | 0.08 | 1405 | 0.09 | 9.2e-09 | 5.95 | 2.69e-09 | 0 | FALSE |
| Brain | Zfp950 | gene expression | Zfp950 | 0.06 | 958 | 0.05 | 3.2e-05 | 5.22 | 1.77e-07 | 0.02 | FALSE |
| Brain | Cacul1 | isoform ratio | NM_001014248.2 | 0.12 | 1786 | 0.09 | 8.4e-09 | 8.04 | 8.84e-16 | 0.86 | FALSE |
| Brain | Cacul1 | isoform ratio | NM_001416001.1 | 0.09 | 1786 | 0.09 | 1.4e-08 | -7.61 | 2.83e-14 | 0.86 | FALSE |
| Brain | Grk5 | isoform ratio | XM_039088828.1 | 0.03 | 8 | 0.04 | 1.6e-04 | -6.94 | 4.04e-12 | 0.04 | FALSE |
| Brain | Cacul1 | intron excision ratio | chr1_259677583_259686255 | 0.12 | 83 | 0.11 | 1.9e-10 | -8.07 | 7.15e-16 | 0.87 | FALSE |
| Brain | Grk5 | mRNA stability | Grk5 | 0.03 | 17 | 0.03 | 4.8e-04 | 6.29 | 3.09e-10 | 0.1 | FALSE |
| IL | Ces2c | gene expression | Ces2c | 0.37 | 1 | 0.29 | 1.1e-07 | -7.1 | 1.21e-12 | 0.52 | FALSE |
| IL | Sfxn4 | gene expression | Sfxn4 | 0.19 | 13 | 0.09 | 3.1e-03 | 7.97 | 1.60e-15 | 0.1 | FALSE |
| IL | Sfxn4 | mRNA stability | Sfxn4 | 0.48 | 1 | 0.18 | 3.8e-05 | -7.1 | 1.27e-12 | 0.05 | FALSE |
| LHb | Ces2c | gene expression | Ces2c | 0.25 | 584 | 0.17 | 9.1e-05 | 6.08 | 1.20e-09 | 0.51 | FALSE |
| LHb | Rab11fip2 | gene expression | Rab11fip2 | 0.23 | 1 | 0.12 | 8.4e-04 | 5.85 | 5.05e-09 | 0.05 | FALSE |
| LHb | Grk5 | mRNA stability | Grk5 | 0.28 | 1449 | 0.09 | 4.3e-03 | -5.24 | 1.58e-07 | 0.05 | FALSE |
| Liver | Nanos1 | gene expression | Nanos1 | 0.08 | 1 | 0.05 | 1.1e-06 | 5.3 | 1.13e-07 | 0 | TRUE |
| Liver | Cacul1 | isoform ratio | NM_001014248.2 | 0.03 | 1784 | 0.02 | 6.6e-03 | 8.05 | 8.31e-16 | 0.4 | FALSE |
| Liver | Ces2c | mRNA stability | Ces2c | 0.02 | 1 | 0.02 | 2.3e-03 | 7.04 | 1.99e-12 | 0.05 | FALSE |
| Liver | Grk5 | mRNA stability | Grk5 | 0.03 | 41 | 0.01 | 3.2e-02 | -7.65 | 1.96e-14 | 0.21 | TRUE |
| NAcc | Grk5 | alternative polyA | XM_039088801.1 | 0.02 | 1 | 0.03 | 2.1e-04 | 7.18 | 7.21e-13 | 0.03 | FALSE |
| NAcc | Grk5 | alternative polyA | XM_039088801.1 | 0.02 | 1 | 0.03 | 5.5e-04 | 7.18 | 7.21e-13 | 0.03 | FALSE |
| NAcc | Ces2c | gene expression | Ces2c | 0.18 | 16 | 0.21 | 9.9e-24 | -6.46 | 1.06e-10 | 0.78 | FALSE |
| NAcc | Prlhr | gene expression | Prlhr | 0.17 | 76 | 0.12 | 1.1e-13 | -8.82 | 1.17e-18 | 0.9 | TRUE |
| NAcc | Rab11fip2 | gene expression | Rab11fip2 | 0.03 | 20 | 0.03 | 1.3e-04 | 7.3 | 2.82e-13 | 0.31 | FALSE |
| NAcc | Sfxn4 | gene expression | Sfxn4 | 0.05 | 1 | 0.06 | 3.4e-07 | -7.91 | 2.54e-15 | 0.01 | FALSE |
| NAcc | Zfp950 | gene expression | Zfp950 | 0.07 | 22 | 0.08 | 3.7e-09 | -7.45 | 9.03e-14 | 0.46 | FALSE |
| NAcc | Cacul1 | isoform ratio | NM_001014248.2 | 0.06 | 1 | 0.06 | 6.0e-07 | -8.2 | 2.47e-16 | 0.04 | FALSE |
| NAcc | Cacul1 | isoform ratio | NM_001416001.1 | 0.04 | 1786 | 0.04 | 2.4e-05 | -7.44 | 9.87e-14 | 0.28 | FALSE |
| NAcc | Dennd10 | mRNA stability | Dennd10 | 0.02 | 1619 | 0.02 | 8.7e-04 | -8.25 | 1.52e-16 | 0.46 | FALSE |
| NAcc | Fam204a | mRNA stability | Fam204a | 0.02 | 1 | 0.02 | 3.1e-03 | -8.31 | 9.44e-17 | 0.03 | FALSE |
| NAcc | Grk5 | mRNA stability | Grk5 | 0.06 | 1449 | 0.05 | 6.2e-07 | -6.75 | 1.48e-11 | 0.03 | FALSE |
| OFC | Ces2c | gene expression | Ces2c | 0.24 | 1 | 0.24 | 1.7e-06 | -7.1 | 1.21e-12 | 0.31 | FALSE |
| OFC | Rab11fip2 | gene expression | Rab11fip2 | 0.26 | 2382 | 0.2 | 1.7e-05 | -8.15 | 3.51e-16 | 0.38 | FALSE |
| OFC | Rab11fip2 | mRNA stability | Rab11fip2 | 0.22 | 2382 | 0.17 | 8.8e-05 | -7.1 | 1.25e-12 | 0.41 | FALSE |
| PL | Grk5 | alternative polyA | XM_039088801.1 | 0.03 | 1449 | 0.02 | 4.0e-03 | -5.93 | 2.95e-09 | 0.03 | FALSE |
| PL | Grk5 | alternative polyA | XM_039088820.1 | 0.02 | 1 | 0.03 | 5.6e-04 | -7.11 | 1.19e-12 | 0.03 | FALSE |
| PL | Grk5 | alternative polyA | XM_039088801.1 | 0.04 | 1449 | 0.02 | 3.7e-03 | -5.37 | 7.94e-08 | 0.02 | FALSE |
| PL | Grk5 | alternative polyA | XM_039088820.1 | 0.04 | 1 | 0.04 | 4.0e-05 | -7.11 | 1.19e-12 | 0.03 | FALSE |
| PL | Ces2c | gene expression | Ces2c | 0.41 | 82 | 0.37 | 8.2e-43 | -6.61 | 3.75e-11 | 0.78 | FALSE |
| PL | LOC120100068 | gene expression | LOC120100068 | 0.18 | 57 | 0.13 | 2.2e-14 | -5.75 | 8.97e-09 | 0 | FALSE |
| PL | Sfxn4 | gene expression | Sfxn4 | 0.14 | 1405 | 0.12 | 4.8e-13 | 7.43 | 1.10e-13 | 0 | FALSE |
| PL | Zfp950 | gene expression | Zfp950 | 0.04 | 958 | 0.03 | 3.5e-04 | 6.07 | 1.27e-09 | 0.06 | FALSE |
| PL | Cacul1 | isoform ratio | NM_001014248.2 | 0.03 | 1 | 0.02 | 1.2e-03 | -8.7 | 3.20e-18 | 0.09 | FALSE |
| PL | Cacul1 | intron excision ratio | chr1_259677583_259686255 | 0.02 | 1 | 0.02 | 1.6e-03 | -8.19 | 2.55e-16 | 0.03 | FALSE |
| PL | Emx2os | mRNA stability | Emx2os | 0.12 | 13 | 0.06 | 1.1e-06 | -5.39 | 6.99e-08 | 0 | FALSE |
| pVTA | Ces2c | gene expression | Ces2c | 0.4 | 1 | 0.32 | 1.3e-14 | -6.93 | 4.31e-12 | 0.53 | FALSE |
| pVTA | Prlhr | gene expression | Prlhr | 0.09 | 1 | 0.07 | 5.1e-04 | 8.7 | 3.20e-18 | 0.07 | FALSE |
| pVTA | Sfxn4 | gene expression | Sfxn4 | 0.1 | 1405 | 0.08 | 1.8e-04 | 8.27 | 1.39e-16 | 0.46 | FALSE |
| pVTA | Grk5 | mRNA stability | Grk5 | 0.09 | 1 | 0.06 | 1.4e-03 | 5.24 | 1.63e-07 | 0.04 | FALSE |