Hub : Traits : Parametrial fat weight : ← →

chr3:129,554,891-132,693,612

Trait: Parametrial fat weight

Best TWAS P=4.826233e-11 · Best GWAS P=1.763659e-11 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Dstn	gene expression	ENSRNOG00000005924	0.59	0.44	blup	1575	0.48	3.4e-60	-5.9	5.6	1.8e-08	-0.90	0.92	0.08	FALSE
2	Adipose	Dtd1	gene expression	ENSRNOG00000008746	0.28	0.14	lasso	19	0.15	5.0e-16	-5.3	5.4	5.5e-08	-0.88	0.48	0.52	FALSE
3	Adipose	Snrpb2	mRNA stability	ENSRNOG00000004967	0.04	0.01	enet	20	0.01	1.5e-02	5.9	-5.9	3.1e-09	0.74	0.55	0.37	FALSE
4	Adipose	Dstn	mRNA stability	ENSRNOG00000005924	0.83	0.57	enet	184	0.60	1.1e-83	-5.9	5.5	4.9e-08	-0.85	0.94	0.06	TRUE
5	Adipose	Sec23b	mRNA stability	ENSRNOG00000008411	0.08	0.06	top1	1	0.06	5.6e-07	5.2	5.2	2.4e-07	-0.81	0.75	0.18	FALSE
6	BLA	Kif16b	gene expression	ENSRNOG00000004951	0.04	0.04	top1	1	0.04	4.1e-03	6.4	6.4	1.4e-10	-0.91	0.09	0.04	FALSE
7	BLA	Snrpb2	gene expression	ENSRNOG00000004967	0.05	0.02	top1	1	0.02	4.4e-02	6.4	6.4	1.2e-10	-0.94	0.08	0.04	FALSE
8	BLA	Pcsk2	gene expression	ENSRNOG00000005438	0.11	0.07	top1	1	0.07	1.9e-04	5.8	5.8	8.7e-09	-0.97	0.12	0.04	FALSE
9	BLA	Dstn	gene expression	ENSRNOG00000005924	0.84	0.63	enet	268	0.64	9.8e-44	-6.0	6.0	1.6e-09	-0.93	0.73	0.27	FALSE
10	BLA	Dtd1	gene expression	ENSRNOG00000008746	0.25	0.14	lasso	2	0.16	4.4e-09	-5.1	5.4	6.2e-08	-0.78	0.60	0.40	TRUE
11	BLA	Otor	gene expression	ENSRNOG00000028721	0.07	0.04	blup	1960	0.04	2.7e-03	4.4	-5.9	2.9e-09	0.81	0.51	0.25	TRUE
12	BLA	Rbbp9	intron excision ratio	chr3:131927367:131929585	0.14	0.07	top1	1	0.07	8.2e-05	-5.9	5.9	4.2e-09	-0.85	0.08	0.61	FALSE
13	BLA	Rbbp9	intron excision ratio	chr3:131929308:131929585	0.13	0.08	top1	1	0.07	7.7e-05	-5.9	-5.9	4.2e-09	0.84	0.08	0.51	FALSE
14	BLA	Pcsk2	mRNA stability	ENSRNOG00000005438	0.23	0.15	top1	1	0.15	3.1e-08	-6.4	-6.4	1.3e-10	0.99	0.41	0.55	FALSE
15	BLA	Dstn	mRNA stability	ENSRNOG00000005924	0.45	0.38	enet	182	0.39	2.2e-22	-6.4	6.3	2.6e-10	-0.98	0.40	0.60	FALSE
16	BLA	Kat14	mRNA stability	ENSRNOG00000007160	0.05	0.03	enet	4	0.03	9.8e-03	5.4	-5.3	1.3e-07	0.86	0.42	0.15	FALSE
17	Brain	Rrbp1	alternative TSS	ENSRNOT00000055602	0.03	0.02	blup	1597	0.03	2.1e-03	-5.2	-5.7	9.8e-09	0.89	0.47	0.42	FALSE
18	Brain	Rrbp1	alternative TSS	ENSRNOT00000101060	0.03	0.02	blup	1597	0.02	2.7e-03	-5.2	5.8	7.2e-09	-0.90	0.46	0.40	FALSE
19	Brain	Snrpb2	gene expression	ENSRNOG00000004967	0.06	0.03	blup	1963	0.05	1.0e-05	6.2	5.5	4.0e-08	-0.83	0.60	0.40	FALSE
20	Brain	Pcsk2	gene expression	ENSRNOG00000005438	0.38	0.44	top1	1	0.44	3.9e-44	5.8	5.8	5.4e-09	-0.97	0.96	0.04	FALSE
21	Brain	Dstn	gene expression	ENSRNOG00000005924	0.72	0.80	enet	189	0.80	3.2e-120	-5.8	5.9	3.2e-09	-0.92	0.94	0.06	FALSE
22	Brain	Rrbp1	gene expression	ENSRNOG00000005958	0.14	0.15	blup	1597	0.16	4.1e-15	-6.0	-6.0	2.1e-09	0.96	0.66	0.34	FALSE
23	Brain	Sec23b	gene expression	ENSRNOG00000008411	0.78	0.78	enet	128	0.80	7.8e-119	4.8	5.1	3.0e-07	-0.87	0.98	0.02	FALSE
24	Brain	Zfp133	gene expression	ENSRNOG00000027955	0.17	0.16	top1	1	0.16	2.7e-14	-5.2	-5.2	1.9e-07	0.87	0.85	0.15	FALSE
25	Brain	Otor	gene expression	ENSRNOG00000028721	0.10	0.09	enet	25	0.11	5.1e-10	-6.0	-5.3	9.6e-08	0.60	0.65	0.35	FALSE
26	Brain	Snrpb2	intron excision ratio	chr3:130399307:130400989	0.03	0.03	top1	1	0.03	5.7e-04	6.4	6.4	2.0e-10	-0.94	0.07	0.04	FALSE
27	Brain	Sec23b	intron excision ratio	chr3:131955920:131958981	0.30	0.22	enet	118	0.22	3.0e-20	4.6	5.2	2.2e-07	-0.87	0.91	0.09	FALSE
28	Brain	Snrpb2	mRNA stability	ENSRNOG00000004967	0.03	0.01	blup	1963	0.01	1.3e-02	6.5	5.4	7.5e-08	-0.80	0.53	0.31	FALSE
29	Brain	Dstn	mRNA stability	ENSRNOG00000005924	0.71	0.52	enet	239	0.52	1.2e-56	-6.0	5.9	3.7e-09	-0.92	0.94	0.06	FALSE
30	Brain	Smim26	mRNA stability	ENSRNOG00000036971	0.03	0.02	top1	1	0.02	2.7e-03	5.1	5.1	3.1e-07	-0.77	0.08	0.04	FALSE
31	Eye	Dstn	gene expression	ENSRNOG00000005924	0.77	0.20	blup	1048	0.25	1.1e-04	-6.1	6.0	1.8e-09	-0.94	0.48	0.37	FALSE
32	Eye	Sec23b	gene expression	ENSRNOG00000008411	0.81	0.22	lasso	19	0.29	2.1e-05	-5.8	5.7	1.2e-08	-0.87	0.29	0.60	FALSE
33	Eye	Zfp133	intron excision ratio	chr3:131829590:131840865	0.30	0.03	top1	1	0.04	9.9e-02	-6.0	-6.0	2.5e-09	0.87	0.06	0.06	FALSE
34	IL	Pcsk2	gene expression	ENSRNOG00000005438	0.49	0.21	top1	1	0.21	7.5e-06	6.3	6.3	2.4e-10	-0.96	0.11	0.08	FALSE
35	IL	Dstn	gene expression	ENSRNOG00000005924	0.79	0.38	blup	1574	0.39	2.0e-10	-6.0	6.2	5.2e-10	-0.97	0.49	0.51	FALSE
36	IL	NA	gene expression	ENSRNOG00000067833	0.33	0.10	enet	9	0.13	5.9e-04	1.6	5.3	1.0e-07	-0.60	0.65	0.08	FALSE
37	IL	Dstn	mRNA stability	ENSRNOG00000005924	0.54	0.27	blup	1574	0.34	4.2e-09	-6.2	5.9	2.9e-09	-0.90	0.53	0.47	FALSE
38	LHb	Snrpb2	gene expression	ENSRNOG00000004967	0.24	0.15	top1	1	0.15	2.3e-04	6.3	6.3	3.2e-10	-0.94	0.10	0.05	FALSE
39	LHb	Dstn	gene expression	ENSRNOG00000005924	0.80	0.49	enet	8	0.50	1.3e-13	-6.0	6.2	6.1e-10	-0.98	0.64	0.36	FALSE
40	LHb	Rrbp1	gene expression	ENSRNOG00000005958	0.22	0.21	top1	1	0.21	1.0e-05	-6.3	-6.3	2.2e-10	0.95	0.09	0.07	FALSE
41	LHb	Dzank1	gene expression	ENSRNOG00000007440	0.14	0.02	blup	1804	0.04	4.6e-02	-5.0	-5.7	1.1e-08	0.84	0.27	0.40	FALSE
42	LHb	Otor	gene expression	ENSRNOG00000028721	0.26	-0.01	lasso	5	0.01	1.7e-01	5.9	-6.1	1.3e-09	0.79	0.42	0.22	FALSE
43	LHb	Kif16b	mRNA stability	ENSRNOG00000004951	0.11	0.01	enet	6	0.03	7.3e-02	5.8	-5.9	4.2e-09	0.70	0.43	0.34	FALSE
44	LHb	Dstn	mRNA stability	ENSRNOG00000005924	0.39	0.37	top1	1	0.37	8.7e-10	-5.8	5.8	7.0e-09	-0.97	0.49	0.04	FALSE
45	Liver	Kif16b	alternative polyA	ENSRNOT00000036273	0.18	0.14	top1	1	0.14	6.7e-15	6.3	-6.3	2.5e-10	0.92	0.62	0.38	FALSE
46	Liver	Kif16b	alternative polyA	ENSRNOT00000118037	0.18	0.14	top1	1	0.14	1.3e-15	6.3	6.3	2.8e-10	-0.92	0.64	0.36	FALSE
47	Liver	Kif16b	gene expression	ENSRNOG00000004951	0.21	0.17	lasso	12	0.18	3.7e-19	6.5	-6.3	2.8e-10	0.90	0.42	0.58	FALSE
48	Liver	Dstn	gene expression	ENSRNOG00000005924	0.67	0.52	blup	1575	0.53	2.6e-69	-6.1	5.9	4.6e-09	-0.93	0.85	0.15	FALSE
49	Liver	Kat14	gene expression	ENSRNOG00000007160	0.05	0.02	enet	37	0.04	3.9e-05	4.6	-5.4	6.4e-08	0.71	0.91	0.03	FALSE
50	Liver	Rbbp9	gene expression	ENSRNOG00000007972	0.12	0.07	enet	9	0.08	2.9e-09	-4.9	5.2	1.7e-07	-0.78	0.71	0.29	FALSE
51	Liver	Sec23b	gene expression	ENSRNOG00000008411	0.09	0.04	blup	1824	0.05	5.2e-06	-5.3	5.3	1.0e-07	-0.82	0.33	0.67	FALSE
52	Liver	Dtd1	gene expression	ENSRNOG00000008746	0.20	0.08	blup	1829	0.09	1.2e-10	4.6	5.3	1.1e-07	-0.86	0.51	0.49	FALSE
53	Liver	Kif16b	isoform ratio	ENSRNOT00000083061	0.06	0.04	top1	1	0.04	4.7e-05	6.3	-6.3	3.6e-10	0.92	0.34	0.15	FALSE
54	Liver	Kif16b	isoform ratio	ENSRNOT00000118037	0.15	0.13	blup	2140	0.13	4.0e-14	6.3	6.5	9.5e-11	-0.91	0.52	0.48	FALSE
55	Liver	Mgme1	isoform ratio	ENSRNOT00000038865	0.03	0.02	top1	1	0.02	4.0e-03	5.4	-5.4	8.5e-08	0.78	0.05	0.03	FALSE
56	Liver	Mgme1	isoform ratio	ENSRNOT00000098696	0.03	0.02	top1	1	0.02	3.2e-03	5.4	5.4	8.5e-08	-0.78	0.05	0.03	FALSE
57	Liver	Kif16b	intron excision ratio	chr3:129976371:129996958	0.03	0.01	blup	2140	0.01	2.4e-02	4.5	-5.2	1.8e-07	0.76	0.36	0.09	FALSE
58	Liver	Snrpb2	intron excision ratio	chr3:130399307:130400989	0.04	0.03	top1	1	0.03	3.5e-04	-6.2	6.2	4.7e-10	-0.93	0.24	0.07	FALSE
59	Liver	Snrpb2	intron excision ratio	chr3:130399832:130400989	0.06	0.03	blup	1963	0.03	2.4e-04	-6.2	-6.5	1.1e-10	0.94	0.53	0.47	FALSE
60	Liver	Rbbp9	intron excision ratio	chr3:131927367:131929585	0.29	0.20	enet	91	0.21	2.3e-22	-5.2	5.2	2.0e-07	-0.84	0.63	0.37	FALSE
61	Liver	Rbbp9	intron excision ratio	chr3:131929308:131929585	0.29	0.20	lasso	25	0.20	9.7e-22	-5.2	-5.2	2.2e-07	0.82	0.62	0.38	FALSE
62	Liver	Dstn	mRNA stability	ENSRNOG00000005924	0.67	0.50	blup	1575	0.50	1.1e-63	-5.9	5.7	1.2e-08	-0.92	0.90	0.10	FALSE
63	Liver	Rbbp9	mRNA stability	ENSRNOG00000007972	0.04	0.01	blup	1818	0.01	8.2e-03	-5.0	5.7	1.5e-08	-0.87	0.32	0.62	FALSE
64	NAcc	Snrpb2	gene expression	ENSRNOG00000004967	0.04	0.02	top1	1	0.02	1.4e-02	5.8	5.8	6.5e-09	-0.94	0.07	0.03	FALSE
65	NAcc	Pcsk2	gene expression	ENSRNOG00000005438	0.25	0.15	lasso	6	0.15	3.4e-11	5.9	5.7	1.1e-08	-0.89	0.69	0.32	FALSE
66	NAcc	Dstn	gene expression	ENSRNOG00000005924	0.84	0.70	top1	1	0.70	1.4e-71	-6.0	6.0	1.5e-09	-0.98	0.85	0.15	FALSE
67	NAcc	Rrbp1	gene expression	ENSRNOG00000005958	0.11	0.11	top1	1	0.11	2.0e-08	-5.9	-5.9	4.0e-09	0.96	0.91	0.09	FALSE
68	NAcc	Otor	gene expression	ENSRNOG00000028721	0.04	0.01	top1	1	0.01	5.2e-02	6.1	-6.1	7.8e-10	0.94	0.07	0.03	FALSE
69	NAcc	Rbbp9	intron excision ratio	chr3:131927367:131929585	0.17	0.08	top1	1	0.08	7.7e-07	-5.1	5.1	3.1e-07	-0.84	0.70	0.13	FALSE
70	NAcc	Rbbp9	intron excision ratio	chr3:131929308:131929585	0.17	0.08	enet	79	0.08	1.7e-06	-5.1	-5.2	2.3e-07	0.87	0.60	0.40	FALSE
71	NAcc	Kif16b	mRNA stability	ENSRNOG00000004951	0.04	0.00	lasso	27	0.01	5.8e-02	-6.5	-6.5	7.8e-11	0.66	0.45	0.47	TRUE
72	NAcc	Dstn	mRNA stability	ENSRNOG00000005924	0.55	0.47	enet	212	0.48	1.3e-39	-6.0	5.9	2.8e-09	-0.90	0.86	0.14	FALSE
73	OFC	Pcsk2	gene expression	ENSRNOG00000005438	0.62	0.36	lasso	9	0.38	5.0e-10	5.1	5.2	2.2e-07	0.63	0.71	0.29	TRUE
74	OFC	Dstn	gene expression	ENSRNOG00000005924	0.82	0.49	enet	41	0.52	1.4e-14	-6.0	5.9	2.9e-09	-0.95	0.57	0.43	FALSE
75	OFC	Dstn	mRNA stability	ENSRNOG00000005924	0.29	0.16	blup	1574	0.19	3.1e-05	-5.8	6.2	6.5e-10	-0.96	0.50	0.48	FALSE
76	PL	Snrpb2	gene expression	ENSRNOG00000004967	0.12	0.10	enet	9	0.11	1.3e-08	6.1	6.3	2.8e-10	-0.93	0.59	0.41	FALSE
77	PL	Pcsk2	gene expression	ENSRNOG00000005438	0.15	0.16	enet	80	0.18	1.0e-13	-6.6	6.4	1.8e-10	-0.95	0.54	0.47	FALSE
78	PL	Dstn	gene expression	ENSRNOG00000005924	0.88	0.60	enet	165	0.62	4.1e-59	-5.7	5.8	5.3e-09	-0.92	0.93	0.07	FALSE
79	PL	Dtd1	gene expression	ENSRNOG00000008746	0.16	0.16	top1	1	0.16	3.3e-12	5.1	5.1	3.1e-07	-0.84	0.71	0.29	FALSE
80	PL	Zfp133	gene expression	ENSRNOG00000027955	0.19	0.12	top1	1	0.12	1.3e-09	-5.2	-5.2	2.0e-07	0.89	0.85	0.14	FALSE
81	PL	Otor	gene expression	ENSRNOG00000028721	0.06	0.04	blup	1972	0.05	1.0e-04	6.2	-6.2	5.0e-10	0.92	0.57	0.43	FALSE
82	PL	Snrpb2	intron excision ratio	chr3:130399307:130400989	0.05	0.03	blup	1963	0.03	2.9e-03	-6.2	6.6	5.2e-11	-0.94	0.53	0.44	FALSE
83	PL	Sec23b	intron excision ratio	chr3:131955920:131958981	0.07	0.04	enet	69	0.05	1.2e-04	5.0	5.4	6.2e-08	-0.84	0.64	0.35	FALSE
84	PL	Snrpb2	mRNA stability	ENSRNOG00000004967	0.09	0.03	enet	41	0.03	1.4e-03	2.2	5.6	1.9e-08	-0.13	0.72	0.19	FALSE
85	PL	Pcsk2	mRNA stability	ENSRNOG00000005438	0.04	0.02	top1	1	0.02	5.4e-03	-6.6	-6.6	4.8e-11	0.98	0.05	0.04	TRUE
86	PL	Dstn	mRNA stability	ENSRNOG00000005924	0.70	0.48	enet	52	0.49	6.1e-42	-5.7	5.7	1.2e-08	-0.92	0.94	0.06	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.