Hub : Traits : Parametrial fat weight : ← →

chr10:56,067,111-58,495,301

Trait: Parametrial fat weight

Best TWAS P=1.916179e-08 · Best GWAS P=3.509082e-08 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Cyb5d2	alternative TSS	ENSRNOT00000036942	0.04	0.02	top1	1	0.02	2.3e-03	-5.5	-5.5	3.7e-08	0.99	0.04	0.06	FALSE
2	Adipose	Cyb5d2	alternative TSS	ENSRNOT00000097276	0.04	0.02	top1	1	0.02	2.8e-03	-5.5	5.5	3.7e-08	-0.99	0.04	0.06	FALSE
3	Adipose	Fbxo39	gene expression	ENSRNOG00000014953	0.10	0.07	top1	1	0.07	2.4e-08	-5.2	-5.2	2.5e-07	0.92	0.52	0.48	FALSE
4	Adipose	Tekt1	gene expression	ENSRNOG00000014973	0.04	0.03	blup	1415	0.03	3.5e-04	-5.2	5.5	4.5e-08	-0.93	0.36	0.60	FALSE
5	Adipose	Spns3	gene expression	ENSRNOG00000015873	0.04	0.02	blup	1252	0.03	7.4e-04	-5.2	5.5	3.8e-08	-0.91	0.36	0.57	FALSE
6	Adipose	Tax1bp3	gene expression	ENSRNOG00000019357	0.19	0.13	top1	1	0.13	6.3e-14	-5.5	5.5	3.6e-08	-1.00	0.11	0.89	FALSE
7	Adipose	Cyb5d2	gene expression	ENSRNOG00000024553	0.03	0.02	top1	1	0.02	1.8e-03	-5.2	-5.2	1.6e-07	1.00	0.03	0.03	FALSE
8	Adipose	Xaf1	gene expression	ENSRNOG00000037371	0.06	0.04	blup	1555	0.04	5.7e-05	-5.1	-5.5	4.5e-08	0.97	0.34	0.65	FALSE
9	Adipose	Atp2a3	isoform ratio	ENSRNOT00000064840	0.03	0.02	top1	1	0.02	1.6e-03	-5.5	5.5	3.5e-08	-0.95	0.03	0.05	FALSE
10	Adipose	Xaf1	isoform ratio	ENSRNOT00000118013	0.03	0.01	top1	1	0.01	1.8e-02	-5.1	-5.1	2.8e-07	0.96	0.05	0.03	FALSE
11	Adipose	Ankfy1	mRNA stability	ENSRNOG00000016212	0.12	0.09	top1	1	0.09	7.9e-10	-5.3	-5.3	1.2e-07	0.99	0.37	0.63	FALSE
12	Adipose	P2rx5	mRNA stability	ENSRNOG00000019208	0.08	0.05	lasso	2	0.05	5.8e-06	-5.5	5.6	1.9e-08	-0.92	0.20	0.80	FALSE
13	Adipose	Cyb5d2	mRNA stability	ENSRNOG00000024553	0.09	0.03	blup	1030	0.05	2.0e-06	-5.5	5.4	5.2e-08	-0.86	0.32	0.68	FALSE
14	Adipose	NA	mRNA stability	ENSRNOG00000067475	0.05	0.02	blup	1702	0.04	4.6e-05	-5.3	5.3	1.2e-07	-0.89	0.42	0.57	FALSE
15	BLA	Xaf1	alternative polyA	ENSRNOT00000056551	0.12	0.09	top1	1	0.09	1.6e-05	-5.4	5.4	7.4e-08	-0.99	0.12	0.26	FALSE
16	BLA	Xaf1	alternative polyA	ENSRNOT00000118013	0.12	0.09	top1	1	0.09	1.1e-05	-5.4	-5.4	7.4e-08	0.99	0.13	0.30	FALSE
17	BLA	Fbxo39	gene expression	ENSRNOG00000014953	0.07	0.04	top1	1	0.04	2.2e-03	-5.1	-5.1	2.9e-07	0.99	0.06	0.04	FALSE
18	BLA	Tekt1	gene expression	ENSRNOG00000014973	0.07	0.02	blup	1415	0.03	1.1e-02	-5.4	5.3	9.1e-08	-0.88	0.27	0.36	FALSE
19	BLA	Smtnl2	gene expression	ENSRNOG00000015157	0.07	0.01	blup	1373	0.02	4.0e-02	-5.2	5.4	6.5e-08	-0.87	0.25	0.33	FALSE
20	BLA	Atp2a3	gene expression	ENSRNOG00000017912	0.14	0.08	top1	1	0.08	6.3e-05	-5.5	5.5	3.7e-08	-0.93	0.06	0.18	FALSE
21	BLA	Camkk1	gene expression	ENSRNOG00000018242	0.14	0.01	enet	4	0.03	8.3e-03	-3.8	-5.4	6.7e-08	0.84	0.27	0.42	FALSE
22	BLA	Zzef1	gene expression	ENSRNOG00000024535	0.16	0.11	top1	1	0.11	1.1e-06	-5.2	5.2	1.6e-07	-0.96	0.25	0.31	FALSE
23	BLA	Xaf1	isoform ratio	ENSRNOT00000056551	0.10	0.06	top1	1	0.06	4.6e-04	-5.4	5.4	7.4e-08	-0.99	0.07	0.08	FALSE
24	BLA	Xaf1	isoform ratio	ENSRNOT00000118013	0.13	0.09	top1	1	0.09	1.4e-05	-5.4	-5.4	7.4e-08	0.99	0.14	0.34	FALSE
25	BLA	Cyb5d2	intron excision ratio	chr10:57407529:57412543	0.08	0.05	top1	1	0.05	9.5e-04	-5.4	-5.4	7.4e-08	0.98	0.05	0.05	FALSE
26	Brain	Xaf1	alternative polyA	ENSRNOT00000056551	0.06	0.05	top1	1	0.05	3.0e-05	-5.3	5.3	1.2e-07	-0.99	0.20	0.37	FALSE
27	Brain	Xaf1	alternative polyA	ENSRNOT00000118013	0.06	0.05	top1	1	0.05	4.4e-05	-5.3	-5.3	1.2e-07	0.99	0.18	0.32	FALSE
28	Brain	RGD1304728	gene expression	ENSRNOG00000014027	0.23	0.22	lasso	20	0.24	1.8e-22	-5.3	-5.4	7.7e-08	0.96	0.34	0.66	FALSE
29	Brain	Spns3	gene expression	ENSRNOG00000015873	0.04	0.04	top1	1	0.04	1.5e-04	-5.3	5.3	1.3e-07	-0.99	0.07	0.07	FALSE
30	Brain	Ankfy1	gene expression	ENSRNOG00000016212	0.09	0.09	top1	1	0.09	5.6e-09	-5.4	-5.4	5.6e-08	0.99	0.22	0.77	FALSE
31	Brain	Xaf1	isoform ratio	ENSRNOT00000056551	0.07	0.04	top1	1	0.04	8.9e-05	-5.3	5.3	1.2e-07	-0.99	0.11	0.17	FALSE
32	Brain	Xaf1	isoform ratio	ENSRNOT00000118013	0.08	0.06	top1	1	0.06	7.1e-06	-5.3	-5.3	1.2e-07	0.99	0.28	0.53	FALSE
33	Brain	Cyb5d2	intron excision ratio	chr10:57400881:57407389	0.03	0.03	enet	7	0.04	2.1e-04	-5.5	-5.4	8.0e-08	0.85	0.23	0.70	FALSE
34	Brain	Pitpnm3	mRNA stability	ENSRNOG00000008323	0.03	0.01	top1	1	0.01	5.4e-02	-5.3	5.3	1.2e-07	-0.88	0.06	0.04	FALSE
35	Brain	Spns2	mRNA stability	ENSRNOG00000057040	0.03	0.02	top1	1	0.02	2.7e-03	-5.2	5.2	1.8e-07	-0.98	0.04	0.04	FALSE
36	Brain	NA	mRNA stability	ENSRNOG00000067475	0.03	0.01	blup	1703	0.02	2.4e-03	-5.2	5.5	3.1e-08	-0.95	0.34	0.58	FALSE
37	Eye	Ankfy1	gene expression	ENSRNOG00000016212	0.29	0.07	top1	1	0.07	3.3e-02	-5.3	-5.3	1.2e-07	0.97	0.06	0.06	FALSE
38	IL	Tekt1	gene expression	ENSRNOG00000014973	0.22	0.03	blup	1407	0.06	1.5e-02	-5.3	5.5	3.9e-08	-0.96	0.21	0.29	FALSE
39	IL	Camkk1	gene expression	ENSRNOG00000018242	0.25	0.06	top1	1	0.06	1.3e-02	-5.3	-5.3	1.0e-07	0.99	0.06	0.06	FALSE
40	Liver	RGD1304728	alternative polyA	ENSRNOT00000110799	0.21	0.13	top1	1	0.13	2.8e-14	-5.3	5.3	1.2e-07	-0.98	0.34	0.66	FALSE
41	Liver	RGD1304728	alternative polyA	ENSRNOT00000115682	0.04	0.02	top1	1	0.02	3.4e-03	-5.2	-5.2	1.8e-07	0.90	0.06	0.04	FALSE
42	Liver	Slc13a5	gene expression	ENSRNOG00000014870	0.37	0.22	top1	1	0.22	1.6e-23	-5.3	-5.3	1.2e-07	0.98	0.34	0.66	FALSE
43	Liver	Cyb5d2	gene expression	ENSRNOG00000024553	0.20	0.13	blup	1030	0.14	3.9e-15	-5.2	-5.6	1.9e-08	0.98	0.25	0.75	TRUE
44	Liver	Spns2	gene expression	ENSRNOG00000057040	0.02	0.01	top1	1	0.01	1.1e-02	-5.4	-5.4	8.3e-08	0.93	0.04	0.03	FALSE
45	Liver	Ube2g1	intron excision ratio	chr10:57226312:57282204	0.03	0.02	top1	1	0.02	2.1e-03	-5.3	5.3	1.2e-07	-0.99	0.04	0.03	FALSE
46	Liver	RGD1304728	intron excision ratio	chr10:56785576:56788896	0.09	0.03	enet	195	0.03	1.7e-04	-5.2	5.6	2.3e-08	-0.98	0.35	0.64	FALSE
47	NAcc	RGD1304728	gene expression	ENSRNOG00000014027	0.05	0.04	top1	1	0.04	3.9e-04	-5.2	-5.2	1.6e-07	0.97	0.06	0.04	FALSE
48	NAcc	Tax1bp3	gene expression	ENSRNOG00000019357	0.08	0.01	blup	1139	0.02	1.5e-02	-5.4	5.2	1.7e-07	-0.84	0.16	0.59	FALSE
49	PL	RGD1304728	gene expression	ENSRNOG00000014027	0.15	0.09	enet	69	0.11	1.9e-08	-5.4	-5.4	6.3e-08	0.92	0.35	0.65	FALSE
50	PL	Tekt1	gene expression	ENSRNOG00000014973	0.06	0.05	top1	1	0.05	1.6e-04	-5.3	5.3	1.0e-07	-0.98	0.06	0.07	FALSE
51	PL	Camkk1	gene expression	ENSRNOG00000018242	0.37	0.13	lasso	3	0.24	4.7e-18	-5.4	-5.4	7.1e-08	0.90	0.18	0.81	FALSE
52	PL	Camkk1	intron excision ratio	chr10:57644145:57644236	0.11	0.11	top1	1	0.11	8.5e-09	-5.3	5.3	1.1e-07	-0.87	0.30	0.69	FALSE
53	PL	NA	mRNA stability	ENSRNOG00000067475	0.06	0.03	top1	1	0.03	1.3e-03	-5.2	5.2	1.6e-07	-0.94	0.06	0.05	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.