Best TWAS P = 5.81e-09 · Best GWAS P= 1.11e-06 conditioned to 4.47e-01
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Eye | Smtnl2 | mRNA stability | Smtnl2 | 0.29 | 513 | 0.17 | 1.3e-03 | 5.54 | 3.01e-08 | 0.26 | FALSE |
| IL | 4933427D14Rikl | alternative polyA | XM_063269343.1 | 0.26 | 93 | 0.06 | 1.6e-02 | 5.43 | 5.72e-08 | 0.23 | FALSE |
| IL | 4933427D14Rikl | alternative polyA | XM_063269343.1 | 0.27 | 27 | 0.06 | 1.7e-02 | 5.48 | 4.29e-08 | 0.26 | FALSE |
| LHb | 4933427D14Rikl | gene expression | 4933427D14Rikl | 0.31 | 220 | 0.14 | 4.2e-04 | -5.82 | 5.81e-09 | 0.33 | TRUE |
| Liver | 4933427D14Rikl | isoform ratio | XR_010055205.1 | 0.06 | 22 | 0.01 | 1.4e-02 | -5.53 | 3.25e-08 | 0.6 | FALSE |
| Liver | 4933427D14Rikl | intron excision ratio | chr10_57282557_57282672 | 0.05 | 118 | 0.02 | 3.4e-03 | -5.58 | 2.47e-08 | 0.44 | FALSE |
| NAcc | 4933427D14Rikl | alternative polyA | NM_001427204.1 | 0.03 | 92 | 0.02 | 1.8e-04 | 5.49 | 3.99e-08 | 0.61 | FALSE |
| NAcc | 4933427D14Rikl | alternative polyA | NM_001427204.1 | 0.03 | 47 | 0.02 | 1.7e-04 | 5.62 | 1.94e-08 | 0.6 | FALSE |
| NAcc | Itgae | intron excision ratio | chr10_58251328_58261109 | 0.04 | 2 | 0.01 | 2.7e-03 | 5.35 | 8.74e-08 | 0.34 | FALSE |
| PL | 4933427D14Rikl | gene expression | 4933427D14Rikl | 0.18 | 1723 | 0.13 | 1.6e-14 | -5.31 | 1.12e-07 | 0.64 | FALSE |
| PL | Tekt1 | gene expression | Tekt1 | 0.08 | 74 | 0.07 | 3.1e-08 | 5.51 | 3.56e-08 | 0.64 | FALSE |
| pVTA | Cyb5d2 | gene expression | Cyb5d2 | 0.11 | 77 | 0.1 | 1.2e-08 | -5.25 | 1.49e-07 | 0.75 | FALSE |